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HIATL2 Gene

protein-coding   GIFtS: 33
GCID: GC09M099663

Hippocampus Abundant Transcript-Like 2

  Search for HIATL2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hippocampus Abundant Transcript-Like 21 2

External Ids:    HGNC: 236721   Entrez Gene: 842782   Ensembl: ENSG000001963127   UniProtKB: Q5VZR43   

Export aliases for HIATL2 gene to outside databases

Previous GC identifers: GC09M095088 GC09P094216 GC09M098748 GC09M099708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HIATL2 Gene:
HIATL2 (hippocampus abundant transcript-like 2) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is HIATL1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIATL2 gene promoter:
         AhR   p53   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   RORalpha2   Arnt   MEF-2A   STAT3   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HIATL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIATL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.33

HIATL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIATL2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099663:  view genomic region     (about GC identifiers)

Start:
99,660,348 bp from pter      End:
99,775,862 bp from pter
Size:
115,515 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HIAL2_HUMAN, Q5VZR4 (See protein sequence)
Recommended Name: Hippocampus abundant transcript-like protein 2  
Size: 134 amino acids; 14477 Da
Sequence caution: Sequence=BC005058; Type=Miscellaneous discrepancy; Note=The sequence differs at the 3' end;
Secondary accessions: Q9BSG7

Explore the universe of human proteins at neXtProt for HIATL2: NX_Q5VZR4

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • ENSEMBL proteins: 
     ENSP00000473444   ENSP00000364371  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q5VZR4

    ProtoNet protein and cluster: Q5VZR4

    UniProtKB/Swiss-Prot: HIAL2_HUMAN, Q5VZR4
    Similarity: Belongs to the major facilitator superfamily


    Find genes that share domains with HIATL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
         
    Find genes that share ontologies with HIATL2           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HIAL2_HUMAN, Q5VZR4: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HIATL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIATL2
    Interactions:

        Search GeneGlobe Interaction Network for HIATL2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HIATL2 (ENSP000003643714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055085transmembrane transport IEA--

    Find genes that share ontologies with HIATL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIATL2 (HIAL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    Unigene Cluster for HIATL2:

    Hippocampus abundant transcript-like 2
    Hs.610084  [show with all ESTs]
    Unigene Representative Sequence: CR627328
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506067 ENST00000602917 ENST00000375223(uc004aws.3)
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    Additional mRNA sequence: 

    BC005058.1 CR627328.1 NR_002894.1 

    12 DOTS entries:

    DT.95172729  DT.100044910  DT.309597  DT.65286186  DT.92464614  DT.95189264  DT.92464621  DT.95259535 
    DT.121173174  DT.121209001  DT.75129618  DT.95283878 

    Selected AceView cDNA sequences (see all 270):

    BX282120 CF994042 CR604727 AI587352 BQ887450 BC021093 CR610965 AI914889 
    BU172529 AA479639 AL597464 BM993288 W48680 AA281842 BG740723 AI243906 
    BG678073 CB046084 BX394093 BU153996 AI571853 BM983143 CF994041 BI030543 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIATL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGACTCC
    HIATL2 Expression
    About this image

    HIATL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.610084
        Custom PCR Arrays for HIATL2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HIATL2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    19(a)
    1 → many
    2(37328731-37372753)
    zebrafish
    (Danio rerio)
    Actinopterygii CU856539.16
    si:ch211-87m7.26
    si:ch211-87m7.2
    17(a)
    17(a)
    many ↔ many
    many ↔ many
    10(2526194-2553189) ENSDARG00000010023
    8(666427-689726) ENSDARG00000030129
    fruit fly
    (Drosophila melanogaster)
    Insecta CG176376
    CG182816
    (see all 4)
    --
    9(a)
    8(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3L(20497286-20498800)
    3L(20492936-20494600)
    worm
    (Caenorhabditis elegans)
    Secernentea T25D3.46
    Protein T25D3.4 (T25D3.4) mRNA, complete cds
    13(a)
    1 → many
    II(147273-152582) WBGene00020798
            Species with no ortholog for HIATL2

    ENSEMBL Gene Tree for HIATL2 (if available)
    TreeFam Gene Tree for HIATL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIATL2 gene
    HIATL12  HIAT12  
    2 SIMAP similar genes for HIATL2 using alignment to 2 protein entries:     HIAL2_HUMAN (see all proteins):
    HIATL1    HIAT1

    Find genes that share paralogs with HIATL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIATL2 (see all 1260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472028661,2
    C--99708164(+) AGCATC/TGTGAA 1 -- int10--------
    rs1403854491,2
    --99708185(+) ATCAGC/TGTTAG 1 -- int10--------
    rs1443342851,2
    C--99708186(+) TCAGCA/GTTAGA 1 -- int10--------
    rs1483938341,2
    --99708199(+) CATATA/GTTAGA 1 -- int10--------
    rs1511041651,2
    C--99708442(+) TTCCTC/GGGTTC 1 -- nc-transcript-variant0--------
    rs2016538281,2
    C--99708456(+) CCATT-/CTCCTG 1 -- nc-transcript-variant0--------
    rs1135594871,2
    C,F--99708490(+) TGCACG/ACCACC 1 -- nc-transcript-variant1Minor allele frequency- A:0.50WA 2
    rs29868811,2
    --99708504(-) aattaG/Tccggg 1 -- spa1 spl30--------
    rs29868801,2
    C--99708578(-) GGATCG/CCTTGA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1816902181,2
    --99708585(+) ATCCAC/TCTGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HIATL2 (99660348 - 99775862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HIATL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738813CNV Deletion23290073
    nsv6625CNV Insertion18451855
    nsv831661CNV Loss17160897
    nsv520001CNV Loss19592680
    nsv893606CNV Gain21882294
    nsv831662CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HIATL2
    DNA2.0 Custom Variant and Variant Library Synthesis for HIATL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIATL2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HIATL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84278 HGNC: 23672 AceView: HIATL2 Ensembl:ENSG00000196312 euGenes: HUgn84278
    ECgene: HIATL2 H-InvDB: HIATL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIATL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIATL2 gene:
    Search GeneIP for patents involving HIATL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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