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Aliases for HIATL1 Gene

Aliases for HIATL1 Gene

  • Hippocampus Abundant Transcript-Like 1 2 3

External Ids for HIATL1 Gene

Previous GeneCards Identifiers for HIATL1 Gene

  • GC09P094272
  • GC09P094282
  • GC09P096176
  • GC09P097136
  • GC09P066801

Summaries for HIATL1 Gene

GeneCards Summary for HIATL1 Gene

HIATL1 (Hippocampus Abundant Transcript-Like 1) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is HIAT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIATL1 Gene

Genomics for HIATL1 Gene

Regulatory Elements for HIATL1 Gene

Genomic Location for HIATL1 Gene

Chromosome:
9
Start:
94,374,322 bp from pter
End:
94,461,042 bp from pter
Size:
86,721 bases
Orientation:
Plus strand

Genomic View for HIATL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIATL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIATL1 Gene

Proteins for HIATL1 Gene

  • Protein details for HIATL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SR56-HIAL1_HUMAN
    Recommended name:
    Hippocampus abundant transcript-like protein 1
    Protein Accession:
    Q5SR56
    Secondary Accessions:
    • B4DUE6
    • E9PD58
    • Q3KQT4
    • Q53GU5
    • Q8WU95
    • Q96SM4

    Protein attributes for HIATL1 Gene

    Size:
    506 amino acids
    Molecular mass:
    54545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI06063.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55274.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96556.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HIATL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIATL1 Gene

Proteomics data for HIATL1 Gene at MOPED

Post-translational modifications for HIATL1 Gene

  • Glycosylation at Asn 463
  • Modification sites at PhosphoSitePlus

Other Protein References for HIATL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIATL1 Gene

Domains & Families for HIATL1 Gene

Protein Domains for HIATL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SR56

UniProtKB/Swiss-Prot:

HIAL1_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with HIATL1: view

No data available for Gene Families for HIATL1 Gene

Function for HIATL1 Gene

Gene Ontology (GO) - Molecular Function for HIATL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
GO:0022891 substrate-specific transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with HIATL1: view
genes like me logo Genes that share phenotypes with HIATL1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIATL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HIATL1 Gene

Localization for HIATL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIATL1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIATL1 Gene COMPARTMENTS Subcellular localization image for HIATL1 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HIATL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with HIATL1: view

Pathways & Interactions for HIATL1 Gene

SuperPathways for HIATL1 Gene

No Data Available

Interacting Proteins for HIATL1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364493%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000366135%0d%0a
Selected Interacting proteins: ENSP00000364493 Q5SR56-HIAL1_HUMAN for HIATL1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for HIATL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IBA --
genes like me logo Genes that share ontologies with HIATL1: view

No data available for Pathways by source and SIGNOR curated interactions for HIATL1 Gene

Drugs & Compounds for HIATL1 Gene

No Compound Related Data Available

Transcripts for HIATL1 Gene

Unigene Clusters for HIATL1 Gene

Hippocampus abundant transcript-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIATL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIATL1 Gene

No ASD Table

Relevant External Links for HIATL1 Gene

GeneLoc Exon Structure for
HIATL1
ECgene alternative splicing isoforms for
HIATL1

Expression for HIATL1 Gene

mRNA expression in normal human tissues for HIATL1 Gene

SOURCE GeneReport for Unigene cluster for HIATL1 Gene Hs.555996

genes like me logo Genes that share expression patterns with HIATL1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HIATL1 Gene

Orthologs for HIATL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HIATL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIATL1 35
  • 89.84 (n)
  • 92.03 (a)
HIATL1 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HIATL1 35
  • 92.29 (n)
  • 93.48 (a)
-- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hiatl1 35
  • 87.78 (n)
  • 90.64 (a)
Hiatl1 16
Hiatl1 36
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HIATL1 35
  • 99.32 (n)
  • 99.32 (a)
HIATL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hiatl1 35
  • 87.38 (n)
  • 90.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HCN2 36
  • 72 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216076 35
  • 70.88 (n)
  • 80.94 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557306 35
  • 67.84 (n)
  • 76.82 (a)
CU856539.1 36
  • 70 (a)
ManyToMany
si:ch211-87m7.2 36
  • 70 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11537 36
  • 38 (a)
ManyToMany
CG17637 36
  • 30 (a)
ManyToMany
CG18281 36
  • 29 (a)
ManyToMany
CG5078 36
  • 47 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T25D3.4 35
  • 56.49 (n)
  • 58.31 (a)
T25D3.4 36
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6571 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6723 36
  • 53 (a)
OneToMany
Species with no ortholog for HIATL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIATL1 Gene

ENSEMBL:
Gene Tree for HIATL1 (if available)
TreeFam:
Gene Tree for HIATL1 (if available)

Paralogs for HIATL1 Gene

Paralogs for HIATL1 Gene

(2) SIMAP similar genes for HIATL1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HIATL1 Gene

genes like me logo Genes that share paralogs with HIATL1: view

Variants for HIATL1 Gene

Sequence variations from dbSNP and Humsavar for HIATL1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_055401 -

Structural Variations from Database of Genomic Variants (DGV) for HIATL1 Gene

Variant ID Type Subtype PubMed ID
nsv893592 CNV Gain 21882294
esv33917 CNV Gain 17666407
nsv893593 CNV Loss 21882294
nsv415866 CNV Loss 16902084
nsv893594 CNV Gain 21882294
esv2675142 CNV Deletion 23128226

Variation tolerance for HIATL1 Gene

Residual Variation Intolerance Score: 54.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIATL1 Gene

HapMap Linkage Disequilibrium report
HIATL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIATL1 Gene

Disorders for HIATL1 Gene

Relevant External Links for HIATL1

Genetic Association Database (GAD)
HIATL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIATL1
genes like me logo Genes that share disorders with HIATL1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIATL1 Gene

Publications for HIATL1 Gene

  1. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 67
  2. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim J.J. … Lee J.K. (J. Hum. Genet. 2010) 67
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for HIATL1 Gene

Sources for HIATL1 Gene

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