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HIATL1 Gene

protein-coding   GIFtS: 46
GCID: GC09P097136

Hippocampus Abundant Transcript-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hippocampus Abundant Transcript-Like 11 2
Hippocampus Abundant Transcript-Like Protein 12

External Ids:    HGNC: 233761   Entrez Gene: 846412   Ensembl: ENSG000001481107   UniProtKB: Q5SR563   

Export aliases for HIATL1 gene to outside databases

Previous GC identifers: GC09P094272 GC09P094282 GC09P096176 GC09P066801


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HIATL1 Gene:
HIATL1 (hippocampus abundant transcript-like 1) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is HIATL2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIATL1 gene promoter:
         AhR   MyoD   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   Arnt   MEF-2A   SRY   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIATL1 promoter sequence
   Search Chromatin IP Primers for HIATL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIATL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.32   Ensembl cytogenetic band:  9q22.32   HGNC cytogenetic band: 9q22.32

HIATL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIATL1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P097136:  view genomic region     (about GC identifiers)

Start:
97,136,833 bp from pter      End:
97,223,324 bp from pter
Size:
86,492 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HIAL1_HUMAN, Q5SR56 (See protein sequence)
Recommended Name: Hippocampus abundant transcript-like protein 1  
Size: 506 amino acids; 54545 Da
Sequence caution: Sequence=AAI06063.1; Type=Erroneous initiation; Sequence=BAB55274.1; Type=Erroneous initiation;
Sequence=BAD96556.1; Type=Erroneous initiation;
Secondary accessions: Q3KQT4 Q53GU5 Q8WU95 Q96SM4

Explore the universe of human proteins at neXtProt for HIATL1: NX_Q5SR56

Explore proteomics data for HIATL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn463
  • Modification sites at PhosphoSitePlus

  • See HIATL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115947.2  
    ENSEMBL proteins: 
     ENSP00000364493   ENSP00000405909  

    HIATL1 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HIATL1 

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for HIATL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001958 Tet-R_TetA/multi-R_MdtG
     IPR011701 MFS
     IPR005829 Sugar_transporter_CS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q5SR56

    ProtoNet protein and cluster: Q5SR56

    UniProtKB/Swiss-Prot: HIAL1_HUMAN, Q5SR56
    Similarity: Belongs to the major facilitator superfamily


    Find genes that share domains with HIATL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
         
    Find genes that share ontologies with HIATL1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HIATL1:
     G0/1 arrest  Increased G1 DNA content  Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIATL1
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    miRNA
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    miRTarBase miRNAs that target HIATL1:
    hsa-mir-192-5p (MIRT026441), hsa-mir-7-5p (MIRT025766), hsa-mir-215-5p (MIRT024844), hsa-mir-128-3p (MIRT045885)

    Block miRNA regulation of human, mouse, rat HIATL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIATL1 (see all 64):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-3613-3p hsa-miR-491-3p hsa-miR-548t hsa-miR-3675-3p
    SwitchGear 3'UTR luciferase reporter plasmidHIATL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HIATL1

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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIATL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HIAL1_HUMAN, Q5SR56: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HIATL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIATL1
    Interactions:

        Search GeneGlobe Interaction Network for HIATL1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for HIATL1 (Q5SR563 ENSP000003644934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC10Q017803, ENSP000003661354I2D: score=2 STRING: ENSP00000366135
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    SCPEP1ENSP000002622884STRING: ENSP00000262288
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055085transmembrane transport IEA--

    Find genes that share ontologies with HIATL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIATL1 (HIAL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIATL1 gene: 
    NM_032558.2  

    Unigene Cluster for HIATL1:

    Hippocampus abundant transcript-like 1
    Hs.555996  [show with all ESTs]
    Unigene Representative Sequence: NM_032558
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375344(uc004aur.3 uc011luh.2) ENST00000428393
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIATL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIATL1 (see all 64):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-3613-3p hsa-miR-491-3p hsa-miR-548t hsa-miR-3675-3p
    SwitchGear 3'UTR luciferase reporter plasmidHIATL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HIATL1
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    OriGene clones in human, mouse for HIATL1 (see all 8)
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    GenScript: all cDNA clones in your preferred vector: HIATL1 (NM_032558)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIATL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIATL1
    Primer
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    OriGene qPCR primer pairs and template standards for HIATL1
    OriGene qSTAR qPCR primer pairs in human, mouse for HIATL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIATL1
      QuantiTect SYBR Green Assays in human, mouse, rat HIATL1
      QuantiFast Probe-based Assays in human, mouse, rat HIATL1

    Additional mRNA sequence: 

    AF255650.1 AK027659.1 AK222836.1 AK300615.1 AL832415.1 BC021093.1 BC106062.1 BX648846.1 

    16 DOTS entries:

    DT.92464619  DT.100793902  DT.100793903  DT.95172738  DT.431290  DT.91816129  DT.95172751  DT.95172970 
    DT.100793906  DT.86811185  DT.95172736  DT.97825646  DT.95172752  DT.95283878  DT.95359714  DT.99968737 

    Selected AceView cDNA sequences (see all 270):

    AA479639 BG678073 CB127645 BX282120 BM993288 BX371764 W48680 BX394093 
    AL597464 AI914889 AI571853 CR610965 BQ887450 BU172529 BM713589 AI624212 
    BG740723 BM983143 AA281842 AI243906 BI030543 AI587352 CF994042 CB046084 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIATL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATACGCA
    HIATL1 Expression
    About this image

    HIATL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIATL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555996
        Custom PCR Arrays for HIATL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIATL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HIATL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hiatl11 , 5 hippocampus abundant transcript-like 11, 5 87.78(n)1
    90.64(a)1
      13 (34.21 cM)5
    666311  NM_001083901.11  NP_001077370.11 
     650646635 
    chicken
    (Gallus gallus)
    Aves HCN26
    Gallus gallus hyperpolarization activated cyclic n...
    72(a)
    many ↔ many
    28(2590049-2598927)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    1 → many
    2(37328731-37372753)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1002160761 uncharacterized LOC100216076 70.88(n)
    80.94(a)
      100216076  NM_001142061.1  NP_001135533.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5573061 hippocampus abundant transcript 1 protein-like 67.84(n)
    76.82(a)
      557306  XM_002663453.3  XP_002663499.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50786
    CG115376
    (see all 4)
    --
    47(a)
    38(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3L(20499132-20500475)
    3L(3128034-3143457)
    worm
    (Caenorhabditis elegans)
    Secernentea T25D3.41 T25D3.4 56.49(n)
    58.31(a)
      188895  NM_061269.4  NP_493670.2 


    ENSEMBL Gene Tree for HIATL1 (if available)
    TreeFam Gene Tree for HIATL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIATL1 gene
    HIATL22  HIAT12  
    2 SIMAP similar genes for HIATL1 using alignment to 2 protein entries:     HIAL1_HUMAN (see all proteins):
    HIATL2    HIAT1

    Find genes that share paralogs with HIATL1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HIATL1
    PGOHUM00000242909


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIATL1 (see all 1633)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403459051,2
    --97134860(+) AAAACC/TATTTG 1 -- us2k10--------
    rs1830147191,2
    --97135125(+) TGAGCC/GGAGAT 1 -- us2k10--------
    rs2020449591,2
    --97135189(+) AAAAA-/GAAAAA 1 -- us2k10--------
    rs1875448651,2
    C--97135190(+) AAAAAA/GAAAAG 1 -- us2k10--------
    rs1932798361,2
    --97135215(+) CGGCTC/TGGTGA 1 -- us2k10--------
    rs625796981,2
    C,F--97135275(+) CAACAC/TGGTGA 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1383883441,2
    C--97135444(+) GTAGCC/TTGGGT 1 -- us2k10--------
    rs1134565641,2
    C--97135471(+) GTCTCAAAT/-  
            
    AAATA
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1138121601,2
    C--97135528(+) TGTGTC/TTGGGG 1 -- us2k10--------
    rs123435811,2
    C--97135675(+) ctcttC/Gcctca 1 -- us2k1 trp30--------

    HapMap Linkage Disequilibrium report for HIATL1 (97136833 - 97223324 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HIATL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675142CNV Deletion23128226
    nsv415866CNV Loss16902084
    nsv893593CNV Loss21882294
    esv33917CNV Gain17666407
    nsv893594CNV Gain21882294
    nsv893592CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIATL1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HIATL1           About GenesLikeMe

    Genetic Association Database (GAD): HIATL1

    Export disorders for HIATL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIATL1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HIATL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. Identification of 15 loci influencing height in a Korean population. (PubMed id 19893584)4 Kim J.J....Lee J.K. (J. Hum. Genet. 2010)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1 Lehner B. and Sanderson C.M. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84641 HGNC: 23376 AceView: HIATL2 Ensembl:ENSG00000148110 euGenes: HUgn84641
    ECgene: HIATL1 H-InvDB: HIATL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIATL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HIATL1 gene:
    Search GeneIP for patents involving HIATL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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