Aliases for HHLA3 Gene
Aliases for HHLA3 Gene
External Ids for HHLA3 Gene
- HGNC: 4906
- Entrez Gene: 11147
- Ensembl: ENSG00000197568
- OMIM: 604372
- UniProtKB: Q9XRX5
Previous GeneCards Identifiers for HHLA3 Gene
- GC01P070944
- GC01P069743
- GC01P070205
- GC01P070190
- GC01P070532
- GC01P070820
- GC01P068931
Summaries for HHLA3 Gene
GeneCards Summary for HHLA3 Gene
HHLA3 (HERV-H LTR-Associating 3) is a Protein Coding gene.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HHLA3 Gene
Genomics for HHLA3 Gene
Regulatory Elements for HHLA3 Gene
Enhancers for HHLA3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around HHLA3 on UCSC Golden Path with GeneCards custom track
Promoters for HHLA3 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around HHLA3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HHLA3 gene promoter:
Regulatory Element Products
Genomic Location for HHLA3 Gene
- Chromosome:
- 1
- Start:
- 70,354,797 bp from pter
- End:
- 70,385,339 bp from pter
- Size:
- 30,543 bases
- Orientation:
- Plus strand
Genomic View for HHLA3 Gene
Genes around HHLA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.1 by Ensembl
- 1p31.1 by Entrez Gene
- 1p31.1 by HGNC
HHLA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HHLA3 Gene
Proteins for HHLA3 Gene
-
Protein details for HHLA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9XRX5-HHLA3_HUMAN
- Recommended name:
- HERV-H LTR-associating protein 3
- Protein Accession:
- Q9XRX5
- D3DQ74
- Q5VZP2
- Q96FH5
- Q9XRX4
Protein attributes for HHLA3 Gene
- Size:
- 114 amino acids
- Molecular mass:
- 12913 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD33288.1; Type=Frameshift; Positions=72; Evidence={ECO:0000305};
Protein Expression for HHLA3 Gene
Post-translational modifications for HHLA3 Gene
Other Protein References for HHLA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HHLA3
- Abcam antibodies for HHLA3
- Search GeneTex for Antibodies for HHLA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for HHLA3
Protein Products
-
OriGene Purified Proteins for HHLA3
- Search Origene for MassSpec and Protein Over-expression Lysates for HHLA3
- Origene Custom Protein Services for HHLA3
- Search GeneTex for Proteins for HHLA3
- Abcam proteins for HHLA3
Assay Products
No data available for DME Specific Peptides for HHLA3 Gene
Domains & Families for HHLA3 Gene
Protein Domains for HHLA3 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for HHLA3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HHLA3 Gene
Function for HHLA3 Gene
Phenotypes for HHLA3 Gene
- GenomeRNAi human phenotypes for HHLA3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HHLA3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HHLA3 gene
- Search ViGene Biosciences for HHLA3
CRISPR Products
-
OriGene CRISPR knockouts for HHLA3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HHLA3
- GenScript: Design CRISPR guide RNA sequences for HHLA3
miRNA for HHLA3 Gene
- miRTarBase miRNAs that target HHLA3
-
- hsa-mir-26b-5p (MIRT028957)
- hsa-mir-1229-5p (MIRT528976)
- hsa-mir-1225-5p (MIRT528977)
- hsa-mir-1227-5p (MIRT528978)
- hsa-mir-3132 (MIRT528979)
- hsa-mir-197-5p (MIRT528980)
- hsa-mir-128-2-5p (MIRT528981)
- hsa-mir-128-1-5p (MIRT528982)
- hsa-mir-6845-5p (MIRT528983)
- hsa-mir-6762-5p (MIRT528984)
- hsa-mir-3159 (MIRT528985)
- hsa-mir-651-3p (MIRT528986)
miRNA Products
- Search ViGene Biosciences for HHLA3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HHLA3
- Browse OriGene Inhibitory RNA Products For HHLA3
-
ViGene Biosciences ready-to-package AAV shRNAs for HHLA3 gene
Clone Products
- OriGene clones in human for HHLA3
- OriGene ORF clones in human for HHLA3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HHLA3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HHLA3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HHLA3 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HHLA3 Gene
Localization for HHLA3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| extracellular | 2 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HHLA3 Gene
Pathways & Interactions for HHLA3 Gene
More details on SuperPathways for HHLA3
No Data Available
Interacting Proteins for HHLA3 Gene
Selected Interacting proteins:
ENSP00000359978
Q9XRX5-HHLA3_HUMAN
for HHLA3 Gene via
STRING
UniProtKB
I2D
| Symbol | External ID(s) | Details |
|---|---|---|
| NMI |
No data available for Pathways by source and SIGNOR curated interactions for HHLA3 Gene
Transcripts for HHLA3 Gene
mRNA/cDNA for HHLA3 Gene
- (6) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HHLA3 Gene
- HERV-H LTR-associating 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HHLA3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HHLA3
- GenScript: Design CRISPR guide RNA sequences for HHLA3
miRNA Products
- Search ViGene Biosciences for HHLA3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HHLA3
- Browse OriGene Inhibitory RNA Products For HHLA3
-
ViGene Biosciences ready-to-package AAV shRNAs for HHLA3 gene
Clone Products
- OriGene clones in human for HHLA3
- OriGene ORF clones in human for HHLA3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||
| SP7: |
Expression for HHLA3 Gene
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HHLA3 Gene
SOURCE GeneReport for Unigene cluster for HHLA3 Gene Hs.142245
mRNA Expression by UniProt/SwissProt for HHLA3 Gene
Q9XRX5-HHLA3_HUMAN
Tissue specificity:
Expressed in kidney and liver.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for HHLA3
-
OriGene qPCR primer pairs for HHLA3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HHLA3 Gene
Orthologs for HHLA3 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HHLA3 36 |
|
OneToOne |
- Species with no ortholog for HHLA3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HHLA3 Gene
No data available for Paralogs for HHLA3 Gene
Variants for HHLA3 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs4233082 | -- | 70,364,966(+) | accag(C/T)acttt | intron-variant | |
| rs4650042 | -- | 70,364,872(+) | TTGAG(A/G)TATtg | intron-variant | |
| rs6661178 | -- | 70,366,370(+) | TATAT(A/G)TATTT | intron-variant | |
| rs9787313 | -- | 70,365,382(+) | ctcac(A/G)tctgt | intron-variant | |
| rs7539544 | -- | 70,366,158(+) | ctttt(C/T)gccga | intron-variant, nc-transcript-variant, reference, synonymous-codon |
Residual Variation Intolerance Score:
61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.72;
46.54% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HHLA3 Gene
Disorders for HHLA3 Gene
Relevant External Links for HHLA3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HHLA3
No disorders were found for HHLA3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HHLA3 Gene
Publications for HHLA3 Gene
- Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3). (PMID: 10444326) Mager D.L. … Freeman J.D. (Genomics 1999) 2 3 4 23 67
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
- Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
Products for HHLA3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HHLA3
- Search Origene for MassSpec and Protein Over-expression Lysates for HHLA3
- Origene Custom Protein Services for HHLA3
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HHLA3
- Browse OriGene Inhibitory RNA Products For HHLA3
- OriGene qPCR primer pairs for HHLA3
- OriGene qPCR primer pairs and template standards for HHLA3
- OriGene CRISPR knockouts for HHLA3
- OriGene clones in human for HHLA3
- OriGene ORF clones in human for HHLA3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for HHLA3
- GenScript Custom Assay Services for HHLA3
- GenScript Custom overexpressing Cell Line Services for HHLA3
- GenScript: Design CRISPR guide RNA sequences for HHLA3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HHLA3
- Novus Biologicals Antibodies for HHLA3
- Novus Biologicals proteins and lysates for HHLA3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HHLA3
- Abcam proteins for HHLA3
- Search for Assays for HHLA3 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for HHLA3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HHLA3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HHLA3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HHLA3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HHLA3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HHLA3 gene
- Search ViGene Biosciences for HHLA3
- Search ViGene Biosciences for HHLA3
- Santa Cruz Biotechnology (SCBT) Antibodies for HHLA3
- Search Santa Cruz Biotechnology (SCBT) for HHLA3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HHLA3
Sources for HHLA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon