HHLA3 Gene

Aliases
for HHLA3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01P070944 GC01P069743 GC01P070205 GC01P070190 GC01P070532 GC01P068931

Summaries
for HHLA3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for HHLA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NC_018912.2  NT_032977.10  

SwitchGear Promoter luciferase reporter plasmid: HHLA3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HHLA3

HHLA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P070820:  view genomic region     (about GC identifiers)

Proteins
for HHLA3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for HHLA3: NX_Q9XRX5

Explore proteomics data for HHLA3 at MOPED


See HHLA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

HHLA3 Human Recombinant Protein Products:

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	OriGene Purified Proteins for HHLA3 OriGene Protein Over-expression Lysate for HHLA3 OriGene MassSpec for HHLA3 OriGene Custom Protein Services for HHLA3
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	Novus Biologicals HHLA3 Protein Novus Biologicals HHLA3 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
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	Cloud-Clone Corp. Proteins for HHLA3
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	Search GeneTex for Proteins for HHLA3
	antibodies-online proteins for HHLA3 (3 products)
	antibodies-online peptides for HHLA3

HHLA3 Antibody Products:

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	Abcam antibodies for HHLA3
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	Search ThermoFisher Antibodies for HHLA3
	antibodies-online antibodies for HHLA3 (12 products)

HHLA3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for HHLA3
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	GenScript Custom Assay Services for HHLA3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for HHLA3 Cloud-Clone Corp. CLIAs for HHLA3
	Search eBioscience for ELISAs for HHLA3
	antibodies-online kits for HHLA3

Domains /
Families
for HHLA3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9XRX5

Function
for HHLA3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for HHLA3

miRNA Products:		miRTarBase miRNAs that target HHLA3: hsa-mir-26b-5p (MIRT028957)
		Block miRNA regulation of human, mouse, rat HHLA3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate HHLA3
		SwitchGear 3'UTR luciferase reporter plasmid: HHLA3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HHLA3
		Predesigned siRNA for gene silencing in human, mouse, rat HHLA3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HHLA3

Clone Products:		OriGene clones in human, mouse for HHLA3 (see all 19) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): HHLA3 (NM_001036645)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HHLA3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HHLA3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HHLA3
		Browse ESI BIO Cell Lines and PureStem Progenitors for HHLA3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHLA3

Localization
for HHLA3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for HHLA3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for HHLA3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for HHLA3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for HHLA3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HHLA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TATACATCCA

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for HHLA3 OriGene qSTAR qPCR primer pairs in human, mouse for HHLA3
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HHLA3
		QuantiTect SYBR Green Assays in human, mouse, rat HHLA3
		QuantiFast Probe-based Assays in human, mouse, rat HHLA3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHLA3

Orthologs
for HHLA3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for HHLA3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for HHLA3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HHLA3 (see all 201)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1448001841,2		--	70822429(+)	ATAGTA/CTTTTT	4	--	int1		0	--	--	--	--
rs1163434781,2	F	--	70822431(+)	AGTCTT/GTTTAG	4	--	int1		1		WA	118
rs1920637461,2	C	--	70822457(+)	GAATAC/GCATAA	4	--	int1		0	--	--	--	--
rs1851078661,2		--	70822677(+)	GAGGCC/TGAGGC	4	--	int1		0	--	--	--	--
rs1903531561,2		--	70822773(+)	ACTTGA/GTCTCA	4	--	int1		0	--	--	--	--
rs1386434051,2		--	70822821(+)	CTCATA/GCTTTA	4	--	int1		0	--	--	--	--
rs1927358661,2		--	70822846(+)	AAGAAC/GAGAAC	4	--	int1		0	--	--	--	--
rs1418605531,2		--	70822867(+)	TATGCA/TGTAAA	4	--	int1		0	--	--	--	--
rs758250741,2	C	--	70822876(+)	AATCAC/GATGAT	4	--	int1		0	--	--	--	--
rs1462585751,2		--	70823056(+)	GGGCTA/GGATTC	4	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for HHLA3 (70820488 - 70851022 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HHLA3:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv27106	CNV	Loss	19812545
nsv830137	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HHLA3

DNA2.0 Custom Variant and Variant Library Synthesis for HHLA3

Disorders / Diseases
for HHLA3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for HHLA3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3). (PubMed id 10444326)^{1, 2, 3, 9} Mager D.L.... Freeman J.D. (Genomics 1999)
2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (Genomics 2007)
5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (Nature 2005)
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for HHLA3 gene

Genome Databases showing HHLA3 gene

Other Databases showing HHLA3 gene

Specialized Databases showing HHLA3 gene

Products
for HHLA3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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