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Aliases for HHLA3 Gene

Aliases for HHLA3 Gene

  • HERV-H LTR-Associating 3 2 3
  • Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 3 4

External Ids for HHLA3 Gene

Summaries for HHLA3 Gene

GeneCards Summary for HHLA3 Gene

HHLA3 (HERV-H LTR-Associating 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HHLA3 Gene

Genomics for HHLA3 Gene

Genomic Location for HHLA3 Gene

Start:
70,354,805 bp from pter
End:
70,385,339 bp from pter
Size:
30,535 bases
Orientation:
Plus strand

Genomic View for HHLA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HHLA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HHLA3 Gene

Regulatory Elements for HHLA3 Gene

Proteins for HHLA3 Gene

  • Protein details for HHLA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9XRX5-HHLA3_HUMAN
    Recommended name:
    HERV-H LTR-associating protein 3
    Protein Accession:
    Q9XRX5
    Secondary Accessions:
    • D3DQ74
    • Q5VZP2
    • Q96FH5
    • Q9XRX4

    Protein attributes for HHLA3 Gene

    Size:
    114 amino acids
    Molecular mass:
    12913 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD33288.1; Type=Frameshift; Positions=72; Evidence={ECO:0000305};

    Alternative splice isoforms for HHLA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HHLA3 Gene

Proteomics data for HHLA3 Gene at MOPED

Post-translational modifications for HHLA3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HHLA3 Gene

Domains for HHLA3 Gene

Protein Domains for HHLA3 Gene

ProtoNet:
genes like me logo Genes that share domains with HHLA3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HHLA3 Gene

Function for HHLA3 Gene

Gene Ontology (GO) - Molecular Function for HHLA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with HHLA3: view

miRNA for HHLA3 Gene

miRTarBase miRNAs that target HHLA3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HHLA3 Gene

Localization for HHLA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HHLA3 Gene COMPARTMENTS Subcellular localization image for HHLA3 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for HHLA3 Gene

Pathways for HHLA3 Gene

SuperPathways for HHLA3 Gene

No Data Available

Interacting Proteins for HHLA3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359978%0d%0a9606.ENSP00000243346%0d%0a
Selected Interacting proteins: ENSP00000359978 Q9XRX5-HHLA3_HUMAN for HHLA3 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for HHLA3 Gene

None

No data available for Pathways by source for HHLA3 Gene

Transcripts for HHLA3 Gene

Unigene Clusters for HHLA3 Gene

HERV-H LTR-associating 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HHLA3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - - -
SP7:

Relevant External Links for HHLA3 Gene

GeneLoc Exon Structure for
HHLA3
ECgene alternative splicing isoforms for
HHLA3

Expression for HHLA3 Gene

mRNA expression in normal human tissues for HHLA3 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HHLA3 Gene

SOURCE GeneReport for Unigene cluster for HHLA3 Gene Hs.142245

mRNA Expression by UniProt/SwissProt for HHLA3 Gene

Q9XRX5-HHLA3_HUMAN
Tissue specificity: Expressed in kidney and liver.
genes like me logo Genes that share expressions with HHLA3: view

Orthologs for HHLA3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HHLA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HHLA3 37
  • 97 (a)
OneToOne
Species with no ortholog for HHLA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HHLA3 Gene

ENSEMBL:
Gene Tree for HHLA3 (if available)
TreeFam:
Gene Tree for HHLA3 (if available)

Paralogs for HHLA3 Gene

No data available for Paralogs for HHLA3 Gene

Variants for HHLA3 Gene

Sequence variations from dbSNP and Humsavar for HHLA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1536614 -- 70,358,742(+) gagat(G/T)acagg intron-variant
rs4233082 -- 70,364,966(+) accag(C/T)acttt intron-variant
rs4620474 -- 70,362,853(+) CGGGC(C/T)GGGCG intron-variant
rs4650042 -- 70,364,872(+) TTGAG(A/G)TATtg intron-variant
rs6661178 -- 70,366,370(+) TATAT(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HHLA3 Gene

Variant ID Type Subtype PubMed ID
nsv830137 CNV Loss 17160897
esv27106 CNV Loss 19812545

Relevant External Links for HHLA3 Gene

HapMap Linkage Disequilibrium report
HHLA3

Disorders for HHLA3 Gene

No disorders were found for HHLA3 Gene.

No data available for UniProtKB/Swiss-Prot for HHLA3 Gene

Publications for HHLA3 Gene

  1. Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3). (PMID: 10444326) Mager D.L. … Freeman J.D. (Genomics 1999) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for HHLA3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HHLA3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HHLA3
    • Block miRNA regulation of HHLA3 using miScript Target Protectors

    Sources for HHLA3 Gene

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