Aliases for HHLA2 Gene
External Ids for HHLA2 Gene
Previous GeneCards Identifiers for HHLA2 Gene
This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for HHLA2 Gene
HHLA2 (HERV-H LTR-Associating 2) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. An important paralog of this gene is CD276.
UniProtKB/Swiss-Prot for HHLA2 Gene
Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.