Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HHLA1 Gene

protein-coding GIFtS: 43
GCID: GC08M133074

HERV-H LTR-associating 1

(Previous symbol: PLA2L)

Explore 3 diseases affiliated with
HHLA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
HERV-H LTR-Associating 1¹ ²
PLA2L¹ ²
HERV-H LTR-Associating Protein 1²

External Ids:	HGNC: 4904¹	Entrez Gene: 10086²	Ensembl: ENSG00000132297⁷	OMIM: 604109⁵	UniProtKB: C9JL84³

Export aliases for HHLA1 gene to outside databases

Previous GC identifers: GC08M131787 GC08M133108 GC08M132746 GC08M133032 GC08M133145 GC08M128391

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HHLA1 gene promoter:
Lmo2 Nkx2-5 HNF-3beta Evi-1 POU2F1 POU2F1a FOXO4 POU2F1b POU2F1c RSRFC4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for HHLA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HHLA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24 Ensembl cytogenetic band: 8q24.22 HGNC cytogenetic band: 8q24

HHLA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HHLA1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M133074: view genomic region (about GC identifiers)

Start:	133,073,733 bp from pter	End:	133,123,406 bp from pter
Size:	49,674 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HHLA1_HUMAN, C9JL84 (See protein sequence)

Recommended Name: HERV-H LTR-associating protein 1 precursor

Size: 531 amino acids; 58297 Da

Subcellular location: Secreted (Potential)

Alternative splicing: 2 isoforms: C9JL84-1 C9JL84-2 (Expressed in teratocarcinoma cell lines)

Explore the universe of human proteins at neXtProt for HHLA1: NX_C9JL84

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_C9JL84

HHLA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001138567.1

ENSEMBL proteins:

ENSP00000407107 ENSP00000388322

Human Recombinant Protein Products for HHLA1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: HHLA1 OriGene Custom Protein Services for HHLA1
	GenScript Custom Purified and Recombinant Proteins Services for HHLA1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HHLA1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

HHLA1 for ontologies About GeneDecksing

HHLA1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HHLA1
	GenScript Custom Superior Antibodies Services for HHLA1
	Abcam antibodies for HHLA1
	Uscn Antibodies for HHLA1
	Search ThermoFisher Antibodies for HHLA1

Assay Products for HHLA1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HHLA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HHLA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: C9JL84

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for HHLA1:

HERVH LTR-associating 1,linked to OC90 by intergenic splicing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HHLA1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HHLA1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HHLA1 (see all 9):
		hsa-miR-4303 hsa-miR-3164 hsa-miR-205 hsa-miR-224 hsa-miR-526b hsa-miR-513a-5p hsa-miR-3921 hsa-miR-889

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HHLA1 (see all 4) OriGene shRNA RFP: HHLA1 OriGene siRNA: HHLA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HHLA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against HHLA1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HHLA1
			Sirion Biotech Customized adenovirus for overexpression of HHLA1 Sirion Biotech Customized adenovirus for potent knockdown of HHLA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HHLA1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HHLA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HHLA1 (NM_001145095)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HHLA1
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HHLA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HHLA1
		Search LifeMap BioReagents cell lines for HHLA1
		Sirion Biotech Customized stable knockdown cell line services for HHLA1 Sirion Biotech Customized inducible knockdown cell line services for HHLA1 Sirion Biotech Customized stable overexpressing cell line services for HHLA1 Sirion Biotech Customized inducible overexpressing cell line services for HHLA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHLA1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HHLA1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for HHLA1 (ENSP00000388322⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMPR2	ENSP00000363708⁴	STRING: ENSP00000363708

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HHLA1
Search CenterWatch for drugs/clinical trials and news about HHLA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HHLA1 gene (2 alternative transcripts):

NM_005712.1 NM_001145095.1

Unigene Cluster for HHLA1:

HERV-H LTR-associating 1

Hs.285026 [show with all ESTs]

Unigene Representative Sequence: NM_001145095

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000473291 ENST00000434736 ENST00000414222(uc003yth.2 uc011liy.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HHLA1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HHLA1 (see all 9):
		hsa-miR-4303 hsa-miR-3164 hsa-miR-205 hsa-miR-224 hsa-miR-526b hsa-miR-513a-5p hsa-miR-3921 hsa-miR-889

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HHLA1 (see all 4) OriGene shRNA RFP: HHLA1 OriGene siRNA: HHLA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HHLA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against HHLA1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HHLA1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HHLA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HHLA1 (NM_001145095)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HHLA1
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HHLA1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HHLA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat HHLA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HHLA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HHLA1

Additional cDNA sequence: AK022619.1

2 DOTS entries:

DT.92048812 DT.120635422

2 AceView cDNA sequences:

AF110315 NM_005712

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HHLA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTATAATCT

About this image

HHLA1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HHLA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HHLA1

SOURCE GeneReport for Unigene cluster: Hs.285026

SABiosciences Custom PCR Arrays for HHLA1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HHLA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat HHLA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HHLA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HHLA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHLA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HHLA1 gene from 3/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hhla1^{1 , 5}	HERV-H LTR-associating 1^{1, 5}	72.64(n)¹ 61.62(a)¹		15 (29.16 cM)⁵ 654498¹ NM_001145096.1¹ NP_001138568.1¹ 65922443⁵
lizard (Anolis carolinensis)	Reptilia	HHLA1⁶	--	42(a)	1 ↔ 1	4(268852-299768)
zebrafish (Danio rerio)	Actinopterygii	BX511268.1⁶	--	64(a)	1 ↔ 1	2(43081596-43082550)

ENSEMBL Gene Tree for HHLA1 (if available)
TreeFam Gene Tree for HHLA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80021642^1,2	F	--	133073236(+)	`GCCAAG/CTGTCC`	2	--	ds500¹ us2k¹		1		WA	118
rs181243756^1,2		--	133073256(+)	`CAAATA/CACCCC`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs2957049^1,2	H	--	133073291(-)	`TTCCAG/AGGATA`	2	--	ds500¹ us2k¹ tfbs³		4		NS EA	420
rs186030051^1,2		--	133073389(+)	`AAATGA/GGAGTT`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs190495610^1,2		--	133073435(+)	`GTCTCA/GTTCAC`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs116786135^1,2	F	--	133073466(+)	`CACCTG/ATGCAG`	2	--	ds500¹ us2k¹		1		WA	118
rs182728430^1,2		--	133073531(+)	`CAAGAA/GACAAA`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs151076772^1,2		--	133073541(+)	`ACACAA/GTCTTT`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs73353135^1,2	C	--	133073570(+)	`CCTCCC/TCCTTT`	2	--	us2k¹ ds500¹		3		WA NA	240
rs187803000^1,2		--	133073572(+)	`TCCCCA/CTTTCC`	2	--	ds500¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HHLA1 (133073733 - 133123406 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HHLA1
3 Indels: 95693 82776 95692

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HHLA1

DNA2.0 Custom Variant and Variant Library Synthesis for HHLA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HHLA1 for disorders           About GeneDecksing

OMIM gene information: 604109    OMIM disorders: --

3 diseases for HHLA1:    About MalaCards

benign paroxysmal positional nystagmus oligohydramnios nystagmus

2 diseases from the University of Copenhagen DISEASES database for HHLA1:

Benign paroxysmal positional nystagmus Oligohydramnios

Export disorders for HHLA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HHLA1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HHLA1)

Utopia: connect your pdf to the dynamic
world of online information

Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. (PubMed id 10329003)^{1, 2, 3, 9} Kowalski P.E....Mager D.L. (1999)
Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene. (PubMed id 8382789)^{1, 2} Feuchter-Murthy A.E.... Mager D.L. (1993)
Web-based, participant-driven studies yield novel gen etic associations for common traits. (PubMed id 20585627)¹ Eriksson N....Mountain J. (2010)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)² Nusbaum C....Lander E.S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
A human endogenous retrovirus suppresses translation of an associated fusion transcript, PLA2L. (PubMed id 9621083)⁹ Kowalski P.E. and Mager D.L. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10086	HGNC: 4904	AceView: HHLA1	Ensembl:ENSG00000132297	euGenes: HUgn10086
ECgene: HHLA1	H-InvDB: HHLA1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HHLA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HHLA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HHLA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HHLA1 gene:
Search GeneIP for patents involving HHLA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HHLA1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HHLA1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HHLA1
	OriGene Protein Over-expression Lysate for HHLA1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HHLA1		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HHLA1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HHLA1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HHLA1		OriGene Custom Protein Services for HHLA1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HHLA1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HHLA1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HHLA1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HHLA1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HHLA1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HHLA1

	GenScript Custom Purified and Recombinant Proteins Services for HHLA1		GenScript cDNA clones with any tag delivered in your preferred vector for HHLA1
	GenScript Custom Assay Services for HHLA1		GenScript Custom Superior Antibodies Services for HHLA1
	GenScript Custom overexpressing Cell Line Services for HHLA1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HHLA1 promoter
	Search Chromatin IP Primers for HHLA1
	RT² qPCR Primer Assay in human, mouse / rat HHLA1
	Search GNC Networks for HHLA1
	SABiosciences Custom PCR Arrays for HHLA1

Search Tocris compounds for HHLA1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Antibodies for HHLA1
	See all of Abcam's Antibodies, Kits and Proteins for HHLA1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HHLA1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HHLA1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHLA1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HHLA1
	Browse SwitchGear Promoter luciferase reporter plasmids for HHLA1

Search ThermoFisher Antibodies for HHLA1

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HHLA1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HHLA1

Sirion Biotech Customized:

	stable knockdown cell line services for HHLA1
	inducible knockdown cell line services for HHLA1
	design and validation of potent shRNA sequences against HHLA1
	adenovirus for potent knockdown of HHLA1
	adenovirus for overexpression of HHLA1
	stable overexpressing cell line services for HHLA1
	inducible overexpressing cell line services for HHLA1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HHLA1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

HHLA1 Gene

HERV-H LTR-associating 1

Aliases
for HHLA1 gene

Summaries
for HHLA1 gene

Genomic Views
for HHLA1 gene

Proteins
for HHLA1 gene

Protein Domains /
Families
for HHLA1 gene

Function
for HHLA1 gene

Pathways & Interactions
for HHLA1 gene

Drugs & Compounds
for HHLA1 gene

Transcripts
for HHLA1 gene

Expression
for HHLA1 gene

Orthologs
for HHLA1 gene

Paralogs
for HHLA1 gene

Genomic Variants
for HHLA1 gene

Disorders / Diseases
for HHLA1 gene

Publications
for HHLA1 gene

External Searches for HHLA1 gene

Genome Databases showing HHLA1 gene

Other Databases showing HHLA1 gene

Specialized Databases showing HHLA1 gene

Intellectual Property
for HHLA1 gene

Products
for HHLA1 gene

View Random Gene

Advanced Search

Export list of displayed genes

HHLA1 Gene

HERV-H LTR-associating 1

Aliasesfor HHLA1 gene

Summariesfor HHLA1 gene

Genomic Viewsfor HHLA1 gene

Proteinsfor HHLA1 gene

Protein Domains /Familiesfor HHLA1 gene

Functionfor HHLA1 gene

Pathways & Interactionsfor HHLA1 gene

Drugs & Compoundsfor HHLA1 gene

Transcriptsfor HHLA1 gene

Expression for HHLA1 gene

Orthologsfor HHLA1 gene

Paralogsfor HHLA1 gene

Genomic Variantsfor HHLA1 gene

Disorders / Diseasesfor HHLA1 gene

Publicationsfor HHLA1 gene

External Searches for HHLA1 gene

Genome Databases showing HHLA1 gene

Other Databases showing HHLA1 gene

Specialized Databases showing HHLA1 gene

Intellectual Propertyfor HHLA1 gene

Productsfor HHLA1 gene

View Random Gene

Aliases
for HHLA1 gene

Summaries
for HHLA1 gene

Genomic Views
for HHLA1 gene

Proteins
for HHLA1 gene

Protein Domains /
Families
for HHLA1 gene

Function
for HHLA1 gene

Pathways & Interactions
for HHLA1 gene

Drugs & Compounds
for HHLA1 gene

Transcripts
for HHLA1 gene

Expression
for HHLA1 gene

Orthologs
for HHLA1 gene

Paralogs
for HHLA1 gene

Genomic Variants
for HHLA1 gene

Disorders / Diseases
for HHLA1 gene

Publications
for HHLA1 gene

Intellectual Property
for HHLA1 gene

Products
for HHLA1 gene