HHIPL2 Gene
protein-coding GIFtS: 45
GCID: GC01M222695
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HHIP-like 2(Previous name: KIAA1822-like )
(Previous symbol: KIAA1822L)
| |
Aliases
for HHIPL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HHIP-Like 21 2 | | Hedgehog Interacting Protein-Like 22 | | KIAA1822L1 2 3 | | HHIP-Like Protein 22 | | FLJ138401 | | HHIP33 | | KIAA1822-Like1 | | |
Export aliases for HHIPL2 gene to outside databasesPrevious GC identifers: GC01M220763 GC01M193369 |
Summaries
for HHIPL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HHIPL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HHIPL2 gene promoter:
MyoD HSF1 (long) NF-kappaB HNF-1A PPAR-alpha HNF-1 Zic1 HSF1short NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HHIPL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HHIPL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41HHIPL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M222695: view genomic region
(about GC identifiers)
Start:
|
222,695,602 bp from pter |
End:
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222,721,445 bp from pter |
Size:
|
25,844 bases |
Orientation:
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minus strand |
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Proteins
for HHIPL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIPL2_HUMAN, Q6UWX4 (See
protein sequence)Recommended Name: HHIP-like protein 2 precursor Size: 724 amino acids; 80779 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAH15201.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH15201.1; Type=Erroneous termination; Positions=452; Note=Translated as Glu; Sequence=AAH15201.1;Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH16552.1;Type=Erroneous initiation; Sequence=BAB14717.1; Type=Erroneous initiation;
Secondary accessions: Q6GU65 Q96BT4 Q96BU5 Q9H8A0Explore the universe of human proteins at neXtProt for HHIPL2: NX_Q6UWX4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UWX4
HHIPL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079022.2
ENSEMBL proteins: ENSP00000342118
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
HHIPL2 for ontologies About GeneDecksing
HHIPL2 Antibody Products:
Assay Products for HHIPL2: |
Protein
Domains /
Families
for HHIPL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HHIPL2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UWX4ProtoNet protein and cluster: Q6UWX4 UniProtKB/Swiss-Prot: HIPL2_HUMAN, Q6UWX4Similarity: Belongs to the HHIP family |
Function
for HHIPL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HHIPL2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HHIPL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HHIPL2 (NM_024746) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HHIPL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HHIPL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHIPL2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016901 | oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor |
IEA | -- | | GO:0048038 | quinone binding |
IEA | -- |
HHIPL2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for HHIPL2:
Animal Models:
Mouse knock-out Hhipl2tm1Lex for HHIPL2
1 MGI phenotypic allele  for Hhipl2 (no phenotypes)
HHIPL2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HHIPL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HHIPL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/23 Interacting proteins for HHIPL2 (ENSP000003421184) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
IEA | -- |
HHIPL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for HHIPL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HHIPL2
Search CenterWatch for drugs/clinical trials and news about HHIPL2 / HIPL2
|
Transcripts
for HHIPL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HHIPL2 gene: NM_024746.3 Unigene Cluster for HHIPL2: HHIP-like 2 Hs.665660 [show with all ESTs]Unigene Representative Sequence: BC0076384 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000343410(uc001hnh.1) ENST00000473144 ENST00000468172 ENST00000494899
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HHIPL2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HHIPL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HHIPL2 (NM_024746) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HHIPL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HHIPL2 |
Additional cDNA sequence: AK023902.1 AY358602.1 BC007638.1 BC015167.1 BC015201.1 BC016552.1 2 DOTS entries: DT.40125464 DT.92369219 16 AceView cDNA sequences: AA884860 AU141539 BQ433070 BC015167 AA812932 BX089001 BQ447786 CB157610 CB157962 BE909936 BU186234 BE878716 BI000332 AU159074 BE072810 BG949302
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for HHIPL2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|
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| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HHIPL2
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Expression
for HHIPL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HHIPL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCTGCTTG
About this image
See HHIPL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HHIPL2
SOURCE GeneReport for Unigene cluster: Hs.665660
SABiosciences Custom PCR Arrays for HHIPL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HHIPL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HHIPL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HHIPL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HHIPL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHIPL2 |
Orthologs
for HHIPL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for HHIPL2 gene from 7/16 species (see all 16) About this table
ENSEMBL Gene Tree for HHIPL2 (if available)
TreeFam Gene Tree for HHIPL2 (if available) |
Paralogs
for HHIPL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HHIPL2 gene
- HHIP2 HHIPL12
2 SIMAP similar genes for HHIPL2 using alignment to 1 protein entry: HIPL2_HUMAN:HHIPL1 HHIP
HHIPL2 for paralogs About GeneDecksing
|
Genomic Variants
for HHIPL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HHIPL2 (222695602 - 222721445 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HHIPL2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HHIPL2 |
|
Disorders
/ Diseases
for HHIPL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HHIPL2 for disorders About GeneDecksing
1  disease for HHIPL2: About MalaCardsthyroiditis
Human Genome Epidemiology (HuGE) Navigator: HHIPL2 (1 document)
Export disorders for HHIPL2 gene to outside databases
|
Publications
for HHIPL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HHIPL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HHIPL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Comparative genomics on HHIP family orthologs. (PubMed id 16391842)2 Katoh Y. and Katoh M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for HHIPL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HHIPL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HHIPL2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing HHIPL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HHIPL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HHIPL2 gene:
Search GeneIP for patents involving HHIPL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HHIPL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HHIPL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HHIPL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HHIPL2 | | | OriGene Protein Over-expression Lysate for HHIPL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HHIPL2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HHIPL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HHIPL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HHIPL2 | | OriGene Custom Protein Services for HHIPL2 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HHIPL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HHIPL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HHIPL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HHIPL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HHIPL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HHIPL2 |
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 |  |  |  | |
| | | | Search Tocris compounds for HHIPL2 |
| |  |  |  |  | | | | |
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 | | | HHIPL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHIPL2 |
|  |  |  | | | | ThermoFisher Antibodies for HHIPL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HHIPL2 |
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