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Aliases for HHIPL2 Gene

Aliases for HHIPL2 Gene

  • HHIP Like 2 2 3 5
  • KIAA1822L 3 4
  • Hedgehog Interacting Protein-Like 2 3
  • HHIP-Like Protein 2 3
  • KIAA1822-Like 2
  • HHIP-Like 2 2
  • HHIP3 4

External Ids for HHIPL2 Gene

Previous HGNC Symbols for HHIPL2 Gene

  • KIAA1822L

Previous GeneCards Identifiers for HHIPL2 Gene

  • GC01M220763
  • GC01M222695
  • GC01M193369

Summaries for HHIPL2 Gene

GeneCards Summary for HHIPL2 Gene

HHIPL2 (HHIP Like 2) is a Protein Coding gene. GO annotations related to this gene include quinone binding and oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor. An important paralog of this gene is HHIPL1.

Additional gene information for HHIPL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HHIPL2 Gene

Genomics for HHIPL2 Gene

Regulatory Elements for HHIPL2 Gene

Enhancers for HHIPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H222520 1 Ensembl ENCODE 34.6 +26.6 26614 1 PKNOX1 FOXA2 MAX RAD21 YY1 SCRT2 ATF7 SOX6 HLF CEBPB HHIPL2 ENSG00000267305
GH01H222581 1.1 Ensembl ENCODE 20.7 -34.5 -34501 2 PKNOX1 JUN INSM2 ZNF140 BATF THRB BCL11B ZEB1 HIC1 ZNF366 TAF1A MIA3 HHIPL2 CICP13 TAF1A-AS1 ENSG00000272750
GH01H222546 1.1 Ensembl ENCODE 17.2 +1.0 978 2 TBP FOXA2 SIN3A FEZF1 NFXL1 GLIS2 RCOR1 FOS EGR2 SP3 HHIPL2 TAF1A ENSG00000267305
GH01H222464 1.8 FANTOM5 Ensembl ENCODE 8.6 +82.5 82536 1 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CICP13 TAF1A ENSG00000272750 HHIPL2 MIA3 TRT-TGT2-1
GH01H222265 1.1 FANTOM5 ENCODE 11.5 +281.7 281702 0 PKNOX1 ZNF473 ZSCAN4 INSM2 FEZF1 ZNF384 ZIC2 HIC1 ZNF121 CTBP1 HHIPL2 GC01P222266 QRSL1P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HHIPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HHIPL2 Gene

Chromosome:
1
Start:
222,522,258 bp from pter
End:
222,548,103 bp from pter
Size:
25,846 bases
Orientation:
Minus strand

Genomic View for HHIPL2 Gene

Genes around HHIPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HHIPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HHIPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HHIPL2 Gene

Proteins for HHIPL2 Gene

  • Protein details for HHIPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWX4-HIPL2_HUMAN
    Recommended name:
    HHIP-like protein 2
    Protein Accession:
    Q6UWX4
    Secondary Accessions:
    • Q6GU65
    • Q96BT4
    • Q96BU5
    • Q9H8A0

    Protein attributes for HHIPL2 Gene

    Size:
    724 amino acids
    Molecular mass:
    80779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15201.1; Type=Erroneous termination; Positions=452; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAH15201.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH16552.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14717.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HHIPL2 Gene

Post-translational modifications for HHIPL2 Gene

  • Glycosylation at isoforms=480
  • Modification sites at PhosphoSitePlus

Other Protein References for HHIPL2 Gene

No data available for DME Specific Peptides for HHIPL2 Gene

Domains & Families for HHIPL2 Gene

Gene Families for HHIPL2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for HHIPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWX4

UniProtKB/Swiss-Prot:

HIPL2_HUMAN :
  • Belongs to the HHIP family.
Family:
  • Belongs to the HHIP family.
genes like me logo Genes that share domains with HHIPL2: view

Function for HHIPL2 Gene

Gene Ontology (GO) - Molecular Function for HHIPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HHIPL2: view
genes like me logo Genes that share phenotypes with HHIPL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HHIPL2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HHIPL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HHIPL2 Gene

Localization for HHIPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HHIPL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HHIPL2 gene
Compartment Confidence
extracellular 4
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Mitochondria (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HHIPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with HHIPL2: view

Pathways & Interactions for HHIPL2 Gene

SuperPathways for HHIPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HHIPL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HHIPL2 Gene

Drugs & Compounds for HHIPL2 Gene

No Compound Related Data Available

Transcripts for HHIPL2 Gene

mRNA/cDNA for HHIPL2 Gene

Unigene Clusters for HHIPL2 Gene

HHIP-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HHIPL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HHIPL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for HHIPL2 Gene

GeneLoc Exon Structure for
HHIPL2
ECgene alternative splicing isoforms for
HHIPL2

Expression for HHIPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HHIPL2 Gene

mRNA differential expression in normal tissues according to GTEx for HHIPL2 Gene

This gene is overexpressed in Testis (x20.9) and Thyroid (x5.4).

Protein differential expression in normal tissues from HIPED for HHIPL2 Gene

This gene is overexpressed in Prostate (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HHIPL2 Gene



Protein tissue co-expression partners for HHIPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HHIPL2 Gene:

HHIPL2

SOURCE GeneReport for Unigene cluster for HHIPL2 Gene:

Hs.665660

Evidence on tissue expression from TISSUES for HHIPL2 Gene

  • Lung(4.4)
  • Muscle(4.2)
  • Kidney(4.1)
  • Thyroid gland(4.1)
genes like me logo Genes that share expression patterns with HHIPL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HHIPL2 Gene

Orthologs for HHIPL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HHIPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HHIPL2 33 34
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia HHIPL2 33 34
  • 86.29 (n)
rat
(Rattus norvegicus)
Mammalia Hhipl2 33
  • 85.37 (n)
dog
(Canis familiaris)
Mammalia HHIPL2 33 34
  • 84.98 (n)
mouse
(Mus musculus)
Mammalia Hhipl2 33 16 34
  • 84.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HHIPL2 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves HHIPL2 33 34
  • 70.35 (n)
lizard
(Anolis carolinensis)
Reptilia HHIPL2 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hhipl2 33
  • 66.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia tthu-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii LOC560376 33
  • 64.77 (n)
HHIPL2 34
  • 49 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39970 33
  • 43.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for HHIPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HHIPL2 Gene

ENSEMBL:
Gene Tree for HHIPL2 (if available)
TreeFam:
Gene Tree for HHIPL2 (if available)

Paralogs for HHIPL2 Gene

Paralogs for HHIPL2 Gene

(2) SIMAP similar genes for HHIPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HHIPL2: view

Variants for HHIPL2 Gene

Sequence variations from dbSNP and Humsavar for HHIPL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000637 -- 222,524,106(+) ATGAG(A/G)ATGAT intron-variant
rs1000095086 -- 222,523,766(+) CCAGA(A/G)GGCGT intron-variant
rs1000182091 -- 222,549,840(+) GCATG(A/G)TGGCG upstream-variant-2KB
rs1000199340 -- 222,549,662(+) GGTGA(A/G)ATTCC upstream-variant-2KB
rs1000353680 -- 222,546,318(+) TGTTT(C/T)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HHIPL2 Gene

Variant ID Type Subtype PubMed ID
esv2762168 CNV loss 21179565
nsv1160091 CNV duplication 26073780

Variation tolerance for HHIPL2 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.08; 80.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HHIPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HHIPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HHIPL2 Gene

Disorders for HHIPL2 Gene

Relevant External Links for HHIPL2

Genetic Association Database (GAD)
HHIPL2
Human Genome Epidemiology (HuGE) Navigator
HHIPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HHIPL2

No disorders were found for HHIPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HHIPL2 Gene

Publications for HHIPL2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for HHIPL2 Gene

Sources for HHIPL2 Gene

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