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Aliases for HHIPL2 Gene

Aliases for HHIPL2 Gene

  • HHIP-Like 2 2 3
  • KIAA1822L 3 4
  • Hedgehog Interacting Protein-Like 2 3
  • HHIP-Like Protein 2 3
  • KIAA1822-Like 2
  • HHIP3 4

External Ids for HHIPL2 Gene

Previous Symbols for HHIPL2 Gene

  • KIAA1822L

Summaries for HHIPL2 Gene

GeneCards Summary for HHIPL2 Gene

HHIPL2 (HHIP-Like 2) is a Protein Coding gene. GO annotations related to this gene include quinone binding and oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor. An important paralog of this gene is HHIPL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HHIPL2 Gene

Genomics for HHIPL2 Gene

Genomic Location for HHIPL2 Gene

222,522,258 bp from pter
222,548,103 bp from pter
25,846 bases
Minus strand

Genomic View for HHIPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HHIPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HHIPL2 Gene

Regulatory Elements for HHIPL2 Gene

Proteins for HHIPL2 Gene

  • Protein details for HHIPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HHIP-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6GU65
    • Q96BT4
    • Q96BU5
    • Q9H8A0

    Protein attributes for HHIPL2 Gene

    724 amino acids
    Molecular mass:
    80779 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH15201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15201.1; Type=Erroneous termination; Positions=452; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAH15201.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH16552.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14717.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HHIPL2 Gene

Proteomics data for HHIPL2 Gene at MOPED

Post-translational modifications for HHIPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn480

Other Protein References for HHIPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HHIPL2 Gene

Domains for HHIPL2 Gene

Suggested Antigen Peptide Sequences for HHIPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HHIP family.:
    • Q6UWX4
genes like me logo Genes that share domains with HHIPL2: view

No data available for Gene Families for HHIPL2 Gene

Function for HHIPL2 Gene

Gene Ontology (GO) - Molecular Function for HHIPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005515 protein binding IPI 25416956
GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA --
GO:0048038 quinone binding IEA --
genes like me logo Genes that share ontologies with HHIPL2: view

Phenotypes for HHIPL2 Gene

genes like me logo Genes that share phenotypes with HHIPL2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HHIPL2 Gene

Localization for HHIPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HHIPL2 Gene


Subcellular locations from

Jensen Localization Image for HHIPL2 Gene COMPARTMENTS Subcellular localization image for HHIPL2 gene
Compartment Confidence
extracellular 3
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HHIPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with HHIPL2: view

Pathways for HHIPL2 Gene

SuperPathways for HHIPL2 Gene

No Data Available

Interacting Proteins for HHIPL2 Gene

Selected Interacting proteins: Q6UWX4-HIPL2_HUMAN for HHIPL2 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for HHIPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HHIPL2: view

No data available for Pathways by source for HHIPL2 Gene

Transcripts for HHIPL2 Gene

mRNA/cDNA for HHIPL2 Gene

Unigene Clusters for HHIPL2 Gene

HHIP-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HHIPL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - -
SP2: -
SP3: -

Relevant External Links for HHIPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HHIPL2 Gene

mRNA expression in normal human tissues for HHIPL2 Gene

mRNA differential expression in normal tissues according to GTEx for HHIPL2 Gene

This gene is overexpressed in Testis (20.9) and Thyroid (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HHIPL2 Gene

SOURCE GeneReport for Unigene cluster for HHIPL2 Gene Hs.665660

genes like me logo Genes that share expressions with HHIPL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HHIPL2 Gene

Orthologs for HHIPL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HHIPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HHIPL2 35
  • 99.26 (n)
  • 99.31 (a)
  • 99 (a)
(Bos Taurus)
Mammalia HHIPL2 35
  • 86.29 (n)
  • 85.87 (a)
  • 79 (a)
(Canis familiaris)
Mammalia HHIPL2 35
  • 84.98 (n)
  • 83.84 (a)
  • 78 (a)
(Mus musculus)
Mammalia Hhipl2 35
  • 84.73 (n)
  • 84.64 (a)
Hhipl2 16
Hhipl2 36
  • 78 (a)
(Monodelphis domestica)
Mammalia HHIPL2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
-- 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Hhipl2 35
  • 85.37 (n)
  • 84.65 (a)
(Gallus gallus)
Aves HHIPL2 35
  • 70.35 (n)
  • 70.85 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia HHIPL2 36
  • 66 (a)
African clawed frog
(Xenopus laevis)
Amphibia tthu-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hhipl2 35
  • 66.62 (n)
  • 67.63 (a)
(Danio rerio)
Actinopterygii HHIPL2 36
  • 49 (a)
LOC560376 35
  • 64.77 (n)
  • 67.33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39970 35
  • 43.81 (n)
  • 36.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for HHIPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HHIPL2 Gene

Gene Tree for HHIPL2 (if available)
Gene Tree for HHIPL2 (if available)

Paralogs for HHIPL2 Gene

Paralogs for HHIPL2 Gene

Selected SIMAP similar genes for HHIPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HHIPL2: view

Variants for HHIPL2 Gene

Sequence variations from dbSNP and Humsavar for HHIPL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs549222 -- 222,523,583(+) AAGGC(C/G)TGAGC intron-variant
rs669174 -- 222,525,207(-) ATTCA(G/T)TTGGC intron-variant
rs958933 -- 222,529,482(+) TATAC(A/T)GGACT intron-variant
rs1487523 -- 222,527,074(+) ACAGG(C/T)AATAA intron-variant
rs1487524 -- 222,527,248(+) GAACC(C/T)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HHIPL2 Gene

Variant ID Type Subtype PubMed ID
nsv873203 CNV Gain 21882294
nsv873205 CNV Loss 21882294

Relevant External Links for HHIPL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HHIPL2 Gene

Disorders for HHIPL2 Gene

Relevant External Links for HHIPL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HHIPL2: view

No data available for UniProtKB/Swiss-Prot for HHIPL2 Gene

Publications for HHIPL2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells. (PMID: 22237814) Doyard M. … Guggenbuhl P. (Osteoporos Int 2012) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for HHIPL2 Gene

Sources for HHIPL2 Gene

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