Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HHIPL1 Gene

Aliases for HHIPL1 Gene

  • HHIP-Like 1 2 3
  • KIAA1822 2 3 4
  • HHIP-Like Protein 1 3
  • ARAR9245 3
  • UNQ9245 3
  • HHIP2 4

External Ids for HHIPL1 Gene

Previous HGNC Symbols for HHIPL1 Gene

  • KIAA1822

Previous GeneCards Identifiers for HHIPL1 Gene

  • GC14P099184
  • GC14P100111
  • GC14P080294

Summaries for HHIPL1 Gene

GeneCards Summary for HHIPL1 Gene

HHIPL1 (HHIP-Like 1) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity and oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor. An important paralog of this gene is HHIPL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HHIPL1 Gene

Genomics for HHIPL1 Gene

Regulatory Elements for HHIPL1 Gene

Genomic Location for HHIPL1 Gene

Start:
99,604,559 bp from pter
End:
99,680,569 bp from pter
Size:
76,011 bases
Orientation:
Plus strand

Genomic View for HHIPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HHIPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HHIPL1 Gene

Proteins for HHIPL1 Gene

  • Protein details for HHIPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JK4-HIPL1_HUMAN
    Recommended name:
    HHIP-like protein 1
    Protein Accession:
    Q96JK4
    Secondary Accessions:
    • A2RUF8
    • B2RN09
    • Q6UXX2

    Protein attributes for HHIPL1 Gene

    Size:
    782 amino acids
    Molecular mass:
    86731 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HHIPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HHIPL1 Gene

Proteomics data for HHIPL1 Gene at MOPED

Post-translational modifications for HHIPL1 Gene

  • Glycosylation at Asn234
  • Modification sites at PhosphoSitePlus

Other Protein References for HHIPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HHIPL1 Gene

Domains for HHIPL1 Gene

Suggested Antigen Peptide Sequences for HHIPL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JK4

UniProtKB/Swiss-Prot:

HIPL1_HUMAN :
  • Q96JK4
Domain:
  • Contains 1 SRCR domain.
Family:
  • Belongs to the HHIP family.
genes like me logo Genes that share domains with HHIPL1: view

No data available for Gene Families for HHIPL1 Gene

Function for HHIPL1 Gene

Gene Ontology (GO) - Molecular Function for HHIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity --
GO:0005044 scavenger receptor activity IEA --
GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA --
GO:0048038 quinone binding IEA --
genes like me logo Genes that share ontologies with HHIPL1: view

Phenotypes for HHIPL1 Gene

GenomeRNAi human phenotypes for HHIPL1:
genes like me logo Genes that share phenotypes with HHIPL1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HHIPL1 Gene

Localization for HHIPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HHIPL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HHIPL1 Gene COMPARTMENTS Subcellular localization image for HHIPL1 gene
Compartment Confidence
extracellular 3
plasma membrane 3
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HHIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HHIPL1: view

Pathways for HHIPL1 Gene

SuperPathways for HHIPL1 Gene

No Data Available

Interacting Proteins for HHIPL1 Gene

Gene Ontology (GO) - Biological Process for HHIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HHIPL1: view

No data available for Pathways by source for HHIPL1 Gene

Transcripts for HHIPL1 Gene

mRNA/cDNA for HHIPL1 Gene

Unigene Clusters for HHIPL1 Gene

HHIP-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HHIPL1 Gene

No ASD Table

Relevant External Links for HHIPL1 Gene

GeneLoc Exon Structure for
HHIPL1
ECgene alternative splicing isoforms for
HHIPL1

Expression for HHIPL1 Gene

mRNA expression in normal human tissues for HHIPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HHIPL1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HHIPL1 Gene

SOURCE GeneReport for Unigene cluster for HHIPL1 Gene Hs.288522

genes like me logo Genes that share expressions with HHIPL1: view

No data available for mRNA Expression by UniProt/SwissProt for HHIPL1 Gene

Orthologs for HHIPL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HHIPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HHIPL1 35
  • 96.14 (n)
  • 95.1 (a)
HHIPL1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HHIPL1 35
  • 86.1 (n)
  • 83.11 (a)
HHIPL1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HHIPL1 35
  • 85.82 (n)
  • 82.78 (a)
HHIPL1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hhipl1 35
  • 82.4 (n)
  • 81.79 (a)
Hhipl1 16
Hhipl1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HHIPL1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HHIPL1 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hhipl1 35
  • 82.1 (n)
  • 81.27 (a)
chicken
(Gallus gallus)
Aves HHIPL1 35
  • 67.69 (n)
  • 71.41 (a)
HHIPL1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HHIPL1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hhipl1 35
  • 62.35 (n)
  • 66.88 (a)
zebrafish
(Danio rerio)
Actinopterygii hhipl1 35
  • 62.14 (n)
  • 67.28 (a)
hhipl1 36
  • 62 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G74790 35
  • 44.85 (n)
  • 37.81 (a)
rice
(Oryza sativa)
Liliopsida Os12g0639600 35
  • 48.57 (n)
  • 40.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for HHIPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HHIPL1 Gene

ENSEMBL:
Gene Tree for HHIPL1 (if available)
TreeFam:
Gene Tree for HHIPL1 (if available)

Paralogs for HHIPL1 Gene

Paralogs for HHIPL1 Gene

Selected SIMAP similar genes for HHIPL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HHIPL1: view

Variants for HHIPL1 Gene

Sequence variations from dbSNP and Humsavar for HHIPL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs767068 -- 99,623,505(+) TCAAC(C/T)TCCTG upstream-variant-2KB, intron-variant
rs941549 -- 99,634,350(-) GTCAC(C/G)GGGGA intron-variant
rs941550 -- 99,634,345(-) GGGGG(A/G)CTTCC intron-variant
rs941551 -- 99,633,601(-) GCTCC(C/T)CTGCC intron-variant
rs943885 -- 99,677,304(-) TAGTG(G/T)AGCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HHIPL1 Gene

Variant ID Type Subtype PubMed ID
dgv1978n71 CNV Loss 21882294
nsv519710 CNV Loss 19592680
nsv902223 CNV Loss 21882294
nsv902224 CNV Loss 21882294
nsv470667 CNV Loss 18288195

Relevant External Links for HHIPL1 Gene

HapMap Linkage Disequilibrium report
HHIPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HHIPL1 Gene

Disorders for HHIPL1 Gene

Relevant External Links for HHIPL1

Genetic Association Database (GAD)
HHIPL1
Human Genome Epidemiology (HuGE) Navigator
HHIPL1
genes like me logo Genes that share disorders with HHIPL1: view

No data available for UniProtKB/Swiss-Prot for HHIPL1 Gene

Publications for HHIPL1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H. … Samani N.J. (Nat. Genet. 2011) 3 48
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4

Products for HHIPL1 Gene

Sources for HHIPL1 Gene

Back to Top

Content