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Aliases for HHIPL1 Gene

Aliases for HHIPL1 Gene

  • HHIP Like 1 2 3 5
  • KIAA1822 2 3 4
  • HHIP-Like Protein 1 3
  • HHIP-Like 1 2
  • ARAR9245 3
  • UNQ9245 3
  • HHIP2 4

External Ids for HHIPL1 Gene

Previous HGNC Symbols for HHIPL1 Gene

  • KIAA1822

Previous GeneCards Identifiers for HHIPL1 Gene

  • GC14P099184
  • GC14P100111
  • GC14P080294

Summaries for HHIPL1 Gene

Entrez Gene Summary for HHIPL1 Gene

  • This gene encodes a protein that belongs to the glucose/sorbosone dehydrogenase family. The encoded protein also contains a domain that binds folate and reduced folic acid derivatives. [provided by RefSeq, Jul 2016]

GeneCards Summary for HHIPL1 Gene

HHIPL1 (HHIP Like 1) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity and oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor. An important paralog of this gene is HHIPL2.

Additional gene information for HHIPL1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HHIPL1 Gene

Genomics for HHIPL1 Gene

Regulatory Elements for HHIPL1 Gene

Enhancers for HHIPL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H099560 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.2 -35.4 -35432 18 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CCDC85C CCNK ENSG00000234648 ENSG00000247970 HHIPL1 RPL3P4 EML1 SETD3 GC14P099584 GC14M099518
GH14H099594 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -5.5 -5467 8.7 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF121 GATA2 ATF7 HHIPL1 BEGAIN ENSG00000247970 CCDC85C PIR41630
GH14H099670 0.7 ENCODE 25.4 +67.1 67079 1.6 SP5 NR2F2 RARA ZFHX2 MAFF HNF4G FOXP2 HNF4A BCL6 MAFK HHIPL1 GC14P099668 CYP46A1
GH14H099766 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10 +163.3 163325 2.8 RFX1 RNF2 BMI1 RAD21 YY1 ZNF121 JUND FOS HNF4A MAFK EML1 HHIPL1 GC14M099754 GC14M099882
GH14H099743 1.3 Ensembl ENCODE dbSUPER 10.9 +141.4 141364 4 ZSCAN4 ZBTB40 RAD21 SCRT2 FOS ZNF654 ZNF362 NR2F2 ZNF217 PRDM6 WDR25 HHIPL1 EML1 GC14P099742 GC14M099754
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HHIPL1 on UCSC Golden Path with GeneCards custom track

Promoters for HHIPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072980 -38 2401 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143
ENSR00000276068 -1538 201 CTCF MXI1 SAP130 ARID4B SIN3A MAX RAD21 KMT2B SCRT2 SMC3

Genomic Locations for HHIPL1 Gene

Genomic Locations for HHIPL1 Gene
76,132 bases
Plus strand

Genomic View for HHIPL1 Gene

Genes around HHIPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HHIPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HHIPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HHIPL1 Gene

Proteins for HHIPL1 Gene

  • Protein details for HHIPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HHIP-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A2RUF8
    • B2RN09
    • Q6UXX2

    Protein attributes for HHIPL1 Gene

    782 amino acids
    Molecular mass:
    86731 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HHIPL1 Gene


neXtProt entry for HHIPL1 Gene

Post-translational modifications for HHIPL1 Gene

  • Glycosylation at posLast=234234
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HHIPL1 Gene

Domains & Families for HHIPL1 Gene

Gene Families for HHIPL1 Gene

Suggested Antigen Peptide Sequences for HHIPL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HHIP family.
  • Belongs to the HHIP family.
genes like me logo Genes that share domains with HHIPL1: view

Function for HHIPL1 Gene

Phenotypes From GWAS Catalog for HHIPL1 Gene

Gene Ontology (GO) - Molecular Function for HHIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity IEA --
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with HHIPL1: view
genes like me logo Genes that share phenotypes with HHIPL1: view

Animal Models for HHIPL1 Gene

MGI Knock Outs for HHIPL1:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HHIPL1 Gene

Localization for HHIPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HHIPL1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HHIPL1 gene
Compartment Confidence
extracellular 4
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HHIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HHIPL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HHIPL1 Gene

Pathways & Interactions for HHIPL1 Gene

SuperPathways for HHIPL1 Gene

No Data Available

Interacting Proteins for HHIPL1 Gene

Gene Ontology (GO) - Biological Process for HHIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HHIPL1: view

No data available for Pathways by source and SIGNOR curated interactions for HHIPL1 Gene

Drugs & Compounds for HHIPL1 Gene

No Compound Related Data Available

Transcripts for HHIPL1 Gene

mRNA/cDNA for HHIPL1 Gene

Unigene Clusters for HHIPL1 Gene

HHIP-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HHIPL1 Gene

No ASD Table

Relevant External Links for HHIPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HHIPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HHIPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HHIPL1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HHIPL1 Gene

Protein tissue co-expression partners for HHIPL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HHIPL1 Gene:


SOURCE GeneReport for Unigene cluster for HHIPL1 Gene:


Evidence on tissue expression from TISSUES for HHIPL1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with HHIPL1: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HHIPL1 Gene

Orthologs for HHIPL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HHIPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HHIPL1 33 34
  • 96.14 (n)
(Bos Taurus)
Mammalia HHIPL1 33 34
  • 86.1 (n)
(Canis familiaris)
Mammalia HHIPL1 33 34
  • 85.82 (n)
(Mus musculus)
Mammalia Hhipl1 33 16 34
  • 82.4 (n)
(Rattus norvegicus)
Mammalia Hhipl1 33
  • 82.1 (n)
(Monodelphis domestica)
Mammalia HHIPL1 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia HHIPL1 34
  • 46 (a)
(Gallus gallus)
Aves HHIPL1 33 34
  • 67.69 (n)
(Anolis carolinensis)
Reptilia HHIPL1 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hhipl1 33
  • 62.35 (n)
(Danio rerio)
Actinopterygii hhipl1 33 34
  • 62.14 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G74790 33
  • 44.85 (n)
(Oryza sativa)
Liliopsida Os12g0639600 33
  • 48.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for HHIPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HHIPL1 Gene

Gene Tree for HHIPL1 (if available)
Gene Tree for HHIPL1 (if available)

Paralogs for HHIPL1 Gene

Paralogs for HHIPL1 Gene

(5) SIMAP similar genes for HHIPL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HHIPL1: view

Variants for HHIPL1 Gene

Sequence variations from dbSNP and Humsavar for HHIPL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs193920989 Uncertain significance 99,660,375(+) TGAAC(C/G)GCCTC reference, missense
rs1000010381 -- 99,620,338(+) GCCCC(C/T)GGCCT intron-variant
rs1000087685 -- 99,607,919(+) AATGG(A/G)AATAT intron-variant
rs1000178043 -- 99,616,857(+) AAGGA(C/T)CAGCC intron-variant
rs1000293221 -- 99,625,171(+) TGGGC(A/G)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HHIPL1 Gene

Variant ID Type Subtype PubMed ID
nsv565735 CNV loss 21841781
nsv565733 CNV gain 21841781
nsv519710 CNV loss 19592680
nsv470667 CNV loss 18288195
nsv1152321 CNV deletion 26484159
nsv1070235 CNV deletion 25765185
nsv1046296 CNV gain 25217958
esv3635488 CNV gain 21293372
esv3635486 CNV gain 21293372

Variation tolerance for HHIPL1 Gene

Residual Variation Intolerance Score: 8.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HHIPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HHIPL1 Gene

Disorders for HHIPL1 Gene

Relevant External Links for HHIPL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HHIPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HHIPL1 Gene

Publications for HHIPL1 Gene

  1. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 45 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 60
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3 60
  5. Comparative genomics on HHIP family orthologs. (PMID: 16391842) Katoh Y … Katoh M (International journal of molecular medicine 2006) 4 60

Products for HHIPL1 Gene

Sources for HHIPL1 Gene

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