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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HHIP Gene

protein-coding   GIFtS: 56
GCID: GC04P145567

hedgehog interacting protein

(Previous name: hedgehog-interacting protein )
 Explore 24 diseases affiliated with
HHIP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HHIP    

Aliases
for HHIP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hedgehog Interacting Protein1 2
HIP1 2 3 5
Hedgehog-Interacting Protein1 2
FLJ209921

External Ids:    HGNC: 148661   Entrez Gene: 643992   Ensembl: ENSG000001641617   OMIM: 6061785   UniProtKB: Q96QV13   

Export aliases for HHIP gene to outside databases

Previous GC identifers: GC04P146367 GC04P145939 GC04P146144 GC04P145924 GC04P145786 GC04P141298


Summaries
for HHIP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HHIP:
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are
evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes,
including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple
cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is
a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH,
IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of
chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly
associated with human height.(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: HHIP_HUMAN, Q96QV1
Function: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with
members of the hedgehog family

Gene Wiki entry for HHIP


Genomic Views
for HHIP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HHIP gene promoter:
         SRF   GCNF   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   FAC1   GATA-6   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HHIP promoter sequence
   Search SABiosciences Chromatin IP Primers for HHIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HHIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28-q32   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.21-q31.3

HHIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HHIP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P145567:  view genomic region     (about GC identifiers)

Start:
 145,567,173 bp from pter      End:
 145,666,423 bp from pter
Size:
 99,251 bases      Orientation:
 plus strand

Proteins
for HHIP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HHIP_HUMAN, Q96QV1 (See protein sequence)
Recommended Name: Hedgehog-interacting protein precursor  
Size: 700 amino acids; 78851 Da
Subunit: Interacts with all three hedgehog family members, SHH, IHH and DHH
Subcellular location: Cell membrane; Peripheral membrane protein (By similarity). Secreted (By similarity). Note=The
last 22 C-terminal amino acids may participate in cell membrane attachment
Subcellular location: Isoform 2: Cytoplasm (Probable)
Sequence caution: Sequence=BAB14945.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/7 PDB 3D structures from and Proteopedia for HHIP (see all 7):
2WFT (3D)        2WFX (3D)        2WG3 (3D)        2WG4 (3D)        3HO3 (3D)        3HO4 (3D)    
Secondary accessions: Q6PK09 Q8NCI7 Q9BXK3 Q9H1J4 Q9H7E7
Alternative splicing: 2 isoforms:  Q96QV1-1   Q96QV1-2   (Potentially soluble form)

Explore the universe of human proteins at neXtProt for HHIP: NX_Q96QV1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96QV1

    • HHIP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_071920.1  
    ENSEMBL proteins: 
     ENSP00000296575   ENSP00000408587  

    Human Recombinant Protein Products: 
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    Novus Biologicals HHIP Protein
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HHIP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0005887integral to plasma membrane ISS11435703
    GO:0009986cell surface IEA--


    HHIP for ontologies           About GeneDecksing



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    Search for Antibodies for HHIP at Abcam  
    Uscn Antibodies for HHIP
    ThermoFisher Antibodies for HHIP

    Assay Products for HHIP: 
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    Uscn ELISAs and CLIAs for HHIP

    Protein Domains /
    Families
    for HHIP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HHIP for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR012938 Glc/Sorbosone_DH
     IPR018143 Folate_rcpt-like
     IPR000742 EG-like_dom
     IPR011041 Quinoprot_gluc/sorb_DH
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry Q96QV1

    ProtoNet protein and cluster: Q96QV1

    UniProtKB/Swiss-Prot: HHIP_HUMAN, Q96QV1
    Domain: A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding
    Similarity: Belongs to the HHIP family
    Similarity: Contains 2 EGF-like domains


    Function
    for HHIP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HHIP_HUMAN, Q96QV1
    Function: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with
    members of the hedgehog family

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HHIP
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate HHIP (see all 14):
    hsa-miR-411* hsa-miR-3163 hsa-miR-3130-5p hsa-miR-365 hsa-miR-148b* hsa-miR-379* hsa-miR-548o hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmid: HHIP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HHIP (see all 3)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HHIP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HHIP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HHIP (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HHIP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HHIP
    Search LifeMap BioReagents cell lines for HHIP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHIP

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19561609
    GO:0008270zinc ion binding IDA19561609
    GO:0016901oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA--
    GO:0048038quinone binding IEA--
    GO:0097108hedgehog family protein binding IPI19561611


    HHIP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HHIP:
     Increased G1 DNA content 

    Animal Models:
         12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hhip):
     cellular  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  immune system  mortality/aging  nervous system 
     respiratory system  vision/eye 

    HHIP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HHIP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Hedgehog signaling pathway0.41
    2Hedgehog Signaling Pathway
    		Hedgehog Signaling Pathway1.00
    3Signaling events mediated by the Hedgehog family
    		Signaling events mediated by the Hedgehog family1.00
    4Pathways in cancer
    		Pathways in cancer1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for HHIP 
        Hedgehog Signaling Pathway
    Signaling events mediated by the Hedgehog family


    3         Kegg Pathways  (Kegg details for HHIP):
        Hedgehog signaling pathway
    Pathways in cancer
    Basal cell carcinoma


    HHIP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HHIP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for HHIP (Q96QV13 ENSP000002965754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHHQ154653, ENSP000002972614I2D: score=2 STRING: ENSP00000297261
    DHHO433233, ENSP000002669914I2D: score=2 STRING: ENSP00000266991
    IHHQ146233, ENSP000002957314I2D: score=2 STRING: ENSP00000295731
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0007165signal transduction ----
    GO:0007224smoothened signaling pathway IEA--
    GO:0007405neuroblast proliferation IEA--
    GO:0009887organ morphogenesis ----


    HHIP for ontologies           About GeneDecksing



    Drugs & Compounds
    for HHIP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HHIP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HHIP
    1 Novoseek chemical compound relationship for HHIP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostacyclin 48.2 3 18498773 (2), 18755267 (1)

    Search CenterWatch for drugs/clinical trials and news about HHIP 

    Transcripts
    for HHIP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HHIP gene: 
    NM_022475.2  

    Unigene Cluster for HHIP:

    Hedgehog interacting protein
    Hs.507991  [show with all ESTs]
    Unigene Representative Sequence: NM_022475
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296575(uc003ijs.2) ENST00000434550(uc003ijr.2) ENST00000505891
    ENST00000511314 ENST00000515080 ENST00000509630 ENST00000512791 ENST00000503090


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HHIP
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate HHIP (see all 14):
    hsa-miR-411* hsa-miR-3163 hsa-miR-3130-5p hsa-miR-365 hsa-miR-148b* hsa-miR-379* hsa-miR-548o hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmid: HHIP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HHIP (see all 3)
    Browse OriGene siRNA
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    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HHIP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HHIP (NM_022475)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HHIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HHIP 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HHIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HHIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HHIP

    Additional cDNA sequence: 

    AK024645.1 AK074711.1 AK098525.1 AK291849.1 AY009317.1 AY009951.1 AY358747.1 BC009298.2 
    BC015636.2 BC025311.1 

    8 DOTS entries:

    DT.40273179  DT.100718580  DT.92431052  DT.101967163  DT.308583  DT.40314468  DT.75178479  DT.99930858 

    24/91 AceView cDNA sequences (see all 91):

    BC025311 BC015636 BC009298 AA570626 AX810691 NM_022475 AK024645 BM989306 
    BQ009742 BE294659 AW409843 AY009317 BE857261 CB152359 AA723669 BU853361 
    AW263540 AL703371 BP335555 BQ446798 BF307050 BE295378 BF306043 BG210135 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for HHIP (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20
    SP1:        -     -     -                 -                             -                 -                       -           -                     
    SP2:                    -                                                                                                                           
    SP3:                                                                                                                                                
    SP4:              -     -                 -     -                                                                                                   
    SP5:                                      -                                                                                                         


    ECgene alternative splicing isoforms for HHIP

    Expression
    for HHIP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HHIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGGTGTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HHIP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    LungLung MesodermDistal Mesodermal Progenitor CellsLung
    BoneMandibular ProcessBone
    BoneRostral Endochondral Facial BonesBone
    BoneRostral Skull Membranous BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

    See HHIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HHIP

    SOURCE GeneReport for Unigene cluster: Hs.507991

    UniProtKB/Swiss-Prot: HHIP_HUMAN, Q96QV1
    Tissue specificity: Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas,
    and in fetal kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including HHIP: 
              Hedgehog Signaling Pathway in human mouse rat
              Liver Cancer in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHIP

    Orthologs
    for HHIP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HHIP gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hhip1 , 5 Hedgehog-interacting protein1, 5 88.62(n)1
    94.29(a)1    		   8 (37.95 cM)5
    152451  NM_020259.41  NP_064655.41 
     799661155 
    chicken
    (Gallus gallus)    		 Aves HHIP1 hedgehog interacting protein 80.98(n)
    85.44(a)    		   422460  XM_420424.3  XP_420424.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HHIP6
    		 --
    		 89(a)
    		 1 ↔ 1
    		 5(118049868-118130003)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hhip-prov2 hedgehog interacting protein 76.91(n)    BC046952.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hhip1 hedgehog interacting protein 66.72(n)
    68.17(a)    		   326102  NM_001080012.1  NP_001073481.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HIPL26
    AT5G399706
    (see all 3)    		 uncharacterized protein
    (see all 3)    		 19(a)
    19(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 5(25143595-25146459)
    5(15998025-16000813)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 expressed protein
    (see all 3)    		 21(a)
    20(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 7(5022647-5026806)
    12(27396595-27401494)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yliI6
    		 soluble aldose sugar dehydrogenase
    		 15(a)
    		 possible ortholog
    		 Chromosome(877965-879080)


    ENSEMBL Gene Tree for HHIP (if available)
    TreeFam Gene Tree for HHIP (if available) 

    Paralogs
    for HHIP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HHIP gene
    HHIPL22  HHIPL12  
    1 SIMAP similar gene for HHIP using alignment to 1 protein entry:     HHIP_HUMAN:
    HHIPL2

    HHIP for paralogs           About GeneDecksing



    Genomic Variants
    for HHIP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: HHIP_HUMAN, Q96QV1
    Polymorphism: Genetic variations in HHIP define the stature quantitative trait locus 12 (STQTL12) [MIM:612226]. Adult
    height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for
    studying genetic influence on quantitative traits


    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HHIP
         1 CNV: 98908
    Human Gene Mutation Database (HGMD): HHIP

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HHIP
    DNA2.0 Custom Variant and Variant Library Synthesis for HHIP

    Disorders / Diseases
    for HHIP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HHIP for disorders           About GeneDecksing

    OMIM gene information: 606178    OMIM disorders: --

    20/24 diseases for HHIP (see all 24):    About MalaCards
    chronic obstructive pulmonary disease    pulmonary disease    copd    pediatric crohns disease
    pulmonary function    basal cell carcinoma    crohn's disease    holoprosencephaly
    hepatoblastoma    prostate cancer    liver cancer    medulloblastoma
    hepatocellular carcinoma    esophageal cancer    twinning    esophagitis
    pancreatitis    osteoarthritis    lung cancer    adenocarcinoma

    6 Novoseek disease relationships for HHIP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 25.4 1 15294024 (1)
    pancreatic cancer 23 5 15754313 (3)
    cancer 8.5 8 17724792 (4), 15294024 (2)
    adenocarcinoma 2.01 2 17461467 (2)
    prostate cancer 1.21 1 15294024 (1)
    tumors 0 9 15294024 (4), 15482598 (2)

    Human Genome Epidemiology (HuGE) Navigator: HHIP (18 documents)

    Export disorders for HHIP gene to outside databases

    Publications
    for HHIP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HHIP gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with HHIP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3. (PubMed id 11435703)1, 2, 3, 9 Bak M.... Tommerup N. (2001)
    2. The structure of SHH in complex with HHIP reveals a r ecognition role for the Shh pseudo active site in signaling. (PubMed id 19561609)1, 2, 9 Bosanac I....Lazarus R.A. (2009)
    3. Structural insights into hedgehog ligand sequestratio n by the human hedgehog-interacting protein HHIP. (PubMed id 19561611)1, 2, 9 Bishop B....Siebold C. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Hedgehog signaling in animal development: paradigms a nd principles. (PubMed id 11731473)1, 3 Ingham P.W. and McMahon A.P. (2001)
    8. Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma. (PubMed id 18559595)1, 9 Tada M....Omata M. (2008)
    9. Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas. (PubMed id 15754313)1, 9 Kayed H....Friess H. (2005)
    10. Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. (PubMed id 15294024)1, 9 Olsen C.L....Brooks A.R. (2004)

    External Searches for HHIP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HHIP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64399 HGNC: 14866 AceView: HHIP Ensembl:ENSG00000164161 euGenes: HUgn64399
    ECgene: HHIP Kegg: 64399 H-InvDB: HHIP

    Other Databases showing HHIP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HHIP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HHIP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HHIP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HHIP gene:
    Search GeneIP for patents involving HHIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HHIP gene

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    About This Section

     
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