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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HHEX Gene

protein-coding   GIFtS: 64
GCID: GC10P094439

hematopoietically expressed homeobox


(Previous symbol: PRHX)
 Explore 23 diseases affiliated with
HHEX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HHEX    

Aliases
for HHEX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hematopoietically Expressed Homeobox1 2     Homeobox Protein PRH2 3
PRHX1 2 3 5     HMPH2
HEX1 2 3     Hematopoietically-Expressed Homeobox Protein HHEX2
PRH2 3 5     Homeobox, Hematopoietically Expressed2
HOX11L-PEN1 2     Proline-Rich Homeodomain-Containing Transcription Factor2
Homeobox Protein HEX2 3     

External Ids:    HGNC: 49011   Entrez Gene: 30872   Ensembl: ENSG000001528047   OMIM: 6044205   UniProtKB: Q030143   

Export aliases for HHEX gene to outside databases

Previous GC identifers: GC10P093330 GC10P093671 GC10P094580 GC10P094114 GC10P088077


Summaries
for HHEX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HHEX:
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental
processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic
differentiation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HHEX_HUMAN, Q03014
Function: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic
differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by
repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity)

Gene Wiki entry for HHEX


Genomic Views
for HHEX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HHEX gene promoter:
         SRF   PPAR-gamma1   E2F   SRF (504 AA)   STAT3   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HHEX promoter sequence
   Search SABiosciences Chromatin IP Primers for HHEX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HHEX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q23.33

HHEX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HHEX gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P094439:  view genomic region     (about GC identifiers)

Start:
 94,447,945 bp from pter      End:
 94,455,408 bp from pter
Size:
 7,464 bases      Orientation:
 plus strand

Proteins
for HHEX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HHEX_HUMAN, Q03014 (See protein sequence)
Recommended Name: Hematopoietically-expressed homeobox protein HHEX  
Size: 270 amino acids; 30022 Da
Subcellular location: Nucleus (Probable)
Developmental stage: Expressed during hematopoiesis
1 PDB 3D structure from and Proteopedia for HHEX:
2E1O (3D)    
Secondary accessions: B1AQ17 Q96CE9

Explore the universe of human proteins at neXtProt for HHEX: NX_Q03014

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q03014

    • HHEX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002720.1  
    ENSEMBL proteins: 
     ENSP00000282728   ENSP00000450017   ENSP00000447953  

    Human Recombinant Protein Products: 
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    Novus Biologicals HHEX Protein
    Novus Biologicals HHEX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HHEX

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12588764
    GO:0005737cytoplasm IDA12554669
    GO:0032993protein-DNA complex IDA18755198


    HHEX for ontologies           About GeneDecksing



    HHEX Antibody Products: 
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    Uscn ELISAs and CLIAs for HHEX

    Protein Domains /
    Families
    for HHEX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HHEX for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q03014

    ProtoNet protein and cluster: Q03014

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: HHEX_HUMAN, Q03014
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HHEX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HHEX_HUMAN, Q03014
    Function: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic
    differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by
    repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity)

         Genatlas biochemistry entry for HHEX:
    hematopoietically expressed homeo box

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HHEX
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate HHEX (see all 19):
    hsa-miR-3938 hsa-miR-4328 hsa-miR-148b hsa-miR-767-5p hsa-miR-340 hsa-miR-223 hsa-miR-204 hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmid: HHEX 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HHEX (see all 7)
    OriGene shRNA RFP: HHEX
    OriGene siRNA: HHEX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HHEX

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HHEX

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HHEX (see all 3)
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HHEX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HHEX 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HHEX
    Search LifeMap BioReagents cell lines for HHEX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHEX

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI19324893
    GO:0008134transcription factor binding IPI15016828
    GO:0008190eukaryotic initiation factor 4E binding IDA12554669


    HHEX for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HHEX:
     Lamellipodia and high actin ra 

    Animal Models:
         Mouse knock-outs for HHEX: Hhextm1Cwb Hhextm1Ngu
         15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hhex) (see all 16):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  nervous system  respiratory system  taste/olfaction 

    HHEX for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HHEX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of beta-cell development
    		Maturity onset diabetes of the young0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for HHEX):
        Maturity onset diabetes of the young


    HHEX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HHEX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/16 Interacting proteins for HHEX (Q030142, 3 ENSP000002827284) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFEMP2O959672, 3, ENSP000003099534MINT-68355 I2D: score=4 STRING: ENSP00000309953
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-67054 I2D: score=5 STRING: ENSP00000377582
    JUNP054123, ENSP000003602664I2D: score=3 STRING: ENSP00000360266
    PMLP295903, ENSP000002680584I2D: score=3 STRING: ENSP00000268058
    GATA2P237693, ENSP000003456814I2D: score=1 STRING: ENSP00000345681
    About this table

    Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15016828
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001889liver development ----
    GO:0002009morphogenesis of an epithelium ----


    HHEX for ontologies           About GeneDecksing



    Drugs & Compounds
    for HHEX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HHEX
    Search CenterWatch for drugs/clinical trials and news about HHEX 

    Transcripts
    for HHEX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HHEX gene: 
    NM_002729.4  

    Unigene Cluster for HHEX:

    Hematopoietically expressed homeobox
    Hs.118651  [show with all ESTs]
    Unigene Representative Sequence: BC015110
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282728(uc001kid.3) ENST00000551454 ENST00000472590 ENST00000492654


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HHEX
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate HHEX (see all 19):
    hsa-miR-3938 hsa-miR-4328 hsa-miR-148b hsa-miR-767-5p hsa-miR-340 hsa-miR-223 hsa-miR-204 hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmid: HHEX 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HHEX (see all 7)
    OriGene shRNA RFP: HHEX
    OriGene siRNA: HHEX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HHEX
    Clone
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    GenScript: all cDNA clones in your preferred vector: HHEX (NM_002729)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HHEX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HHEX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HHEX

    Additional cDNA sequence: 

    AK309463.1 AK314891.1 BC014336.1 BC015110.1 BC050638.1 L16499.1 X67235.1 Z21533.1 

    4 DOTS entries:

    DT.75129186  DT.95265621  DT.91724822  DT.121255822 

    24/77 AceView cDNA sequences (see all 77):

    AI432673 BE675192 AA385079 BC050638 BM719909 X67235 BQ017608 AI913057 
    AI219552 NM_002729 AI285592 AA384685 BP381515 CD673144 AA314532 BM548028 
    BQ011240 BM543214 BU162190 BG616027 CD103365 AW070387 BE549982 BV188291 

    GeneLoc Exon Structure


    Expression
    for HHEX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HHEX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGACCTTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HHEX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/26 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 26) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasPrepancreatic Ventral Foregut EndodermPre-Pancreatic Foregut Endoderm CellsPancreas
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    EndodermDefinitive EndodermDefinitive Endoderm CellsEarly Embryo, Endoderm
    Gut TubeForegutForegut Endoderm CellsEndoderm
    Gut TubeGut TubePrimitive Gut Endoderm CellsEndoderm
    Gut TubeVentral Foregut EndodermHepatic Endoderm CellsLiver
    Gut TubeVentral Foregut EndodermVentral Foregut Endoderm CellsEndoderm
    HypoblastExtraembryonic Visceral EndodermAnterior Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastExtraembryonic Visceral EndodermDistal Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastHypoblastHypoblast CellsExtraembryonic Tissues
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/14 LifeMap Cells (see all 14) 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Endoderm progenitor-like cells (Generation and expan...)
    Activin A-induced embryoid bodies (Mouse embryonic stem...)
    Definitive endoderm like cells (Efficient derivation...)
    Thyroid Progenitors (Efficient derivation...)Thyroid

    See HHEX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HHEX

    SOURCE GeneReport for Unigene cluster: Hs.118651

    UniProtKB/Swiss-Prot: HHEX_HUMAN, Q03014
    Tissue specificity: Liver and promyelocytic leukemia cell line HL-60

        SABiosciences Expression via Pathway-Focused PCR Array including HHEX: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HHEX

    Orthologs
    for HHEX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HHEX gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hhex1 , 5 hematopoietically expressed homeobox1, 5 88.89(n)1
    92.96(a)1    		   19 (32.28 cM)5
    152421  NM_008245.31  NP_032271.11 
     374328875 
    chicken
    (Gallus gallus)    		 Aves HHEX1 hematopoietically expressed homeobox 75.13(n)
    79.17(a)    		   396182  NM_205252.1  NP_990583.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HHEX6
    		 --
    		 67(a)
    		 1 ↔ 1
    		 GL343219.1(2488154-2508714)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC690422 hypothetical protein MGC69042 77.67(n)    BC059320.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hhex2 hematopoietically expressed homeobox 79.97(n)   30098  AF131070.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG70566
    		 --
    		 19(a)
    		 1 ↔ 1
    		 3R(16902635-16906405)
    worm
    (Caenorhabditis elegans)    		 Secernentea pha-26
    		 defective PHArynx development family member (pha-2...
    		 34(a)
    		 1 ↔ 1
    		 X(633702-637042)


    ENSEMBL Gene Tree for HHEX (if available)
    TreeFam Gene Tree for HHEX (if available) 

    Paralogs
    for HHEX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HHEX gene
    HLX2  DBX22  DBX12  
    11 SIMAP similar genes for HHEX using alignment to 2 protein entries:     HHEX_HUMAN (see all proteins):
    MEOX1    GBX2    GBX1    MNX1    homeobox gene    EMX1
    HOXD8    HOXB8    MEOX2    HOXA1    HLX

    HHEX for paralogs           About GeneDecksing



    Genomic Variants
    for HHEX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/115 NCBI SNPs in HHEX are shown (see all 115)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1871391141,2
    		--94447860(+) GAATAC/GGTCAT 1 -- us2k10--------
    rs9495791,2
    		H,--94447911(+) CATGCC/TCCCTC 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1150672641,2
    		--94448002(+) TTTATG/AATTTA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1505459311,2
    		--94448041(+) TCTTAA/CCTACC 1 -- us2k10--------
    rs1924250381,2
    		--94448079(+) TGTAGC/TACACT 1 -- us2k10--------
    rs741491061,2
    		C,--94448101(+) CTGGGC/TTTGTA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1455842021,2
    		--94448252(+) ACGCTC/TACATG 1 -- us2k10--------
    rs1808351821,2
    		--94448260(+) ATGCTA/GTTCTC 1 -- us2k10--------
    rs741491071,2
    		C,--94448475(+) CATCTG/ATCCTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1852206121,2
    		--94448532(+) AAACTC/TGAACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HHEX (94447945 - 94455408 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HHEX
         1 CNV: 71087
    Human Gene Mutation Database (HGMD): HHEX

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    Disorders / Diseases
    for HHEX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HHEX for disorders           About GeneDecksing

    OMIM gene information: 604420    OMIM disorders: --

    20/23 diseases for HHEX (see all 23):    About MalaCards
    maturity-onset diabetes of the young    type 2 diabetes mellitus    polycystic ovary syndrome    arterial calcification
    coronary heart disease    diabetes mellitus    gangliosidosis    gestational diabetes
    acute myeloid leukemia    myeloid leukemia    hematopoiesis    alzheimer's disease
    pharyngitis    breast carcinoma    leukemia    prostate cancer
    obesity    prostatitis    thyroiditis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for HHEX:
    Diabetes mellitus
    Genetic Association Database (GAD): HHEX
    Human Genome Epidemiology (HuGE) Navigator: HHEX (110 documents)

    Export disorders for HHEX gene to outside databases

    Publications
    for HHEX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HHEX gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with HHEX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells. (PubMed id 8103988)1, 2, 3, 9 Hromas R.A.... Radich J. (1993)
    2. HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. (PubMed id 8096636)1, 2, 3 Bedford F.K.... Wiedemann L.M. (1993)
    3. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. (PubMed id 15024728)1, 4 Ertekin-Taner N....Younkin S.G. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. (PubMed id 14517947)1, 4 Prince J.A....Brookes A.J. (2003)
    6. A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells. (PubMed id 7911091)1, 2 Neidle S. and Goodwin G.H. (1994)
    7. Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. (PubMed id 1360645)1, 2 Crompton M.R.... Goodwin G.H. (1992)
    8. Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter. (PubMed id 15062550)1, 9 Puppin C....Damante G. (2004)
    9. The transcriptional repressor protein PRH interacts with the proteasome. (PubMed id 12826010)1, 9 Bess K.L....Jayaraman P.S. (2003)
    10. Expression and function of the homeodomain-containing protein Hex in thyroid cells. (PubMed id 10871399)1, 9 Pellizzari L....Damante G. (2000)

    External Searches for HHEX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HHEX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3087 HGNC: 4901 AceView: HHEX Ensembl:ENSG00000152804 euGenes: HUgn3087
    ECgene: HHEX Kegg: 3087 H-InvDB: HHEX

    Other Databases showing HHEX gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HHEX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HHEX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HHEX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HHEX gene:
    Search GeneIP for patents involving HHEX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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