Aliases for HHEX Gene
External Ids for HHEX Gene
Previous HGNC Symbols for HHEX Gene
Previous GeneCards Identifiers for HHEX Gene
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for HHEX Gene
HHEX (Hematopoietically Expressed Homeobox) is a Protein Coding gene. Diseases associated with HHEX include gangliosidosis gm2 and sandhoff disease, infantile, juvenile, and adult forms. Among its related pathways are Transcriptional misregulation in cancer and Regulation of beta-cell development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DBX2.
UniProtKB/Swiss-Prot for HHEX Gene
Recognizes the DNA sequence 5-ATTAA-3. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).