Aliases for HHEX Gene
External Ids for HHEX Gene
Previous HGNC Symbols for HHEX Gene
Previous GeneCards Identifiers for HHEX Gene
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for HHEX Gene
HHEX (Hematopoietically Expressed Homeobox) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and Regulation of beta-cell development. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DBX2.
UniProtKB/Swiss-Prot for HHEX Gene
Recognizes the DNA sequence 5-ATTAA-3. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).