Aliases for HHAT Gene
External Ids for HHAT Gene
Previous GeneCards Identifiers for HHAT Gene
'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
GeneCards Summary for HHAT Gene
HHAT (Hedgehog Acyltransferase) is a Protein Coding gene. Diseases associated with HHAT include Chondrodysplasia-Disorder Of Sex Development Syndrome and Thoracic Outlet Syndrome. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling by Hedgehog. GO annotations related to this gene include GTP binding and palmitoyltransferase activity. An important paralog of this gene is HHATL.
UniProtKB/Swiss-Prot for HHAT Gene
Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP.