Aliases for HHAT Gene
External Ids for HHAT Gene
Previous GeneCards Identifiers for HHAT Gene
'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
GeneCards Summary for HHAT Gene
HHAT (Hedgehog Acyltransferase) is a Protein Coding gene. Diseases associated with HHAT include chondrodysplasia-disorder of sex development syndrome and thoracic outlet syndrome. Among its related pathways are Signaling by GPCR and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include GTP binding and palmitoyltransferase activity. An important paralog of this gene is HHATL.
UniProtKB/Swiss-Prot for HHAT Gene
Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP.