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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HGSNAT Gene

protein-coding   GIFtS: 51
GCID: GC08P042995

Heparan-Alpha-Glucosaminide N-Acetyltransferase

(Previous name: transmembrane protein 76)
(Previous symbol: TMEM76)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heparan-Alpha-Glucosaminide N-Acetyltransferase1 2
TMEM761 2 3 5
Transmembrane Protein 761 2 3
MPS3C2 5
HGNAT2
EC 2.3.1.783

External Ids:    HGNC: 265271   Entrez Gene: 1380502   Ensembl: ENSG000001651027   OMIM: 6104535   UniProtKB: Q68CP43   

Export aliases for HGSNAT gene to outside databases

Previous GC identifers: GC08P043117 GC08P041520


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HGSNAT Gene:
This gene encodes a lysosomal acetyltransferase, which is one of several enzymes involved in the lysosomal
degradation of heparin sulfate. Mutations in this gene are associated with Sanfilippo syndrome C, one type of the
lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate.
(provided by RefSeq, Jan 2009)

GeneCards Summary for HGSNAT Gene: 
HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase) is a protein-coding gene. Diseases associated with HGSNAT include mucopolysaccharidosis type iiic, and mucopolysaccharidosis ii, and among its related super-pathways are Metabolic pathways and Metabolism of carbohydrates. GO annotations related to this gene include heparan-alpha-glucosaminide N-acetyltransferase activity and transferase activity, transferring acyl groups.

UniProtKB/Swiss-Prot: HGNAT_HUMAN, Q68CP4
Function: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of
intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl
glucosaminidase

Gene Wiki entry for HGSNAT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HGSNAT gene promoter:
         HOXA9B   HOXA9   GR   Pbx1a   LCR-F1   Meis-1b   GR-alpha   AP-2alpha   AP-2alphaA   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HGSNAT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HGSNAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.1   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.1

HGSNAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HGSNAT gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P042995:  view genomic region     (about GC identifiers)

Start:
42,995,556 bp from pter      End:
43,057,998 bp from pter
Size:
62,443 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HGNAT_HUMAN, Q68CP4 (See protein sequence)
Recommended Name: Heparan-alpha-glucosaminide N-acetyltransferase  
Size: 663 amino acids; 73293 Da
Subunit: Homooligomer. Homooligomerization is necessary for enzyme activity
Subcellular location: Lysosome membrane; Multi-pass membrane protein. Note=Colocalizes with the lysosomal marker
LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is
probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine-
and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain
Miscellaneous: A signal sequence is predicted but has been shown not to be cleaved in the reticulum endoplasmic
Secondary accessions: B4E2V0
Alternative initiation: 2 isoforms:  Q68CP4-1   Q68CP4-2   (Intralysosomal proteolytic cleavage is faster and enzymatic activity higher than isoform 2)

Explore the universe of human proteins at neXtProt for HGSNAT: NX_Q68CP4

Explore proteomics data for HGSNAT at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes intralysosomal proteolytic cleavage; occurs within the end of the first and/or the beginning of the
    second luminal domain and is essential for the activation of the enzyme
  • UniProtKB: Glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68CP4

  • HGSNAT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HGSNAT Protein Expression
    REFSEQ proteins: NP_689632.2  
    ENSEMBL proteins: 
     ENSP00000368965   ENSP00000430032   ENSP00000429109   ENSP00000430151   ENSP00000428322  
     ENSP00000429029   ENSP00000389524   ENSP00000297798  
    Reactome Protein details: Q68CP4
    Human Recombinant Protein Products for HGSNAT: 
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    Cloud-Clone Corp. Proteins for HGSNAT 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane TAS--
    GO:0016021integral to membrane IEA--

    HGSNAT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012429 DUF1624

    Graphical View of Domain Structure for InterPro Entry Q68CP4

    ProtoNet protein and cluster: Q68CP4


    HGSNAT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HGNAT_HUMAN, Q68CP4
    Function: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of
    intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl
    glucosaminidase
    Catalytic activity: Acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate
    N-acetyl-alpha-D-glucosaminide

         Enzyme Number (IUBMB): EC 2.3.1.781

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015019heparan-alpha-glucosaminide N-acetyltransferase activity IEA--
    GO:0016746transferase activity, transferring acyl groups IDA19823584
         
    HGSNAT for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HGSNAT 
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HGSNAT:
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HGSNAT About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Mucopolysaccharidoses0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS IV - Morquio syndrome B0.48
    MPS I - Hurler syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS IX - Natowicz syndrome0.48
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.56
    HS-GAG degradation0.40
    4Lysosome
    Lysosome
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/18        Reactome Pathways for HGSNAT (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome
    MPS IIIA - Sanfilippo syndrome A


    3         Kegg Pathways  (Kegg details for HGSNAT):
        Glycosaminoglycan degradation
    Metabolic pathways
    Lysosome


    HGSNAT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HGSNAT

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HGSNAT (ENSP000003689654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAGLUENSP000002259274STRING: ENSP00000225927
    SGSHENSP000003146064STRING: ENSP00000314606
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--
    GO:0007041lysosomal transport IDA--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    HGSNAT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HGSNAT (HGNAT)

    3 HMDB Compounds for HGSNAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Heparan sulfateHHS 5 (see all 13)9050-30-0--

    Search CenterWatch for drugs/clinical trials and news about HGSNAT / HGNAT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HGSNAT gene: 
    NM_152419.2  

    Unigene Cluster for HGSNAT:

    Heparan-alpha-glucosaminide N-acetyltransferase
    Hs.600384  [show with all ESTs]
    Unigene Representative Sequence: NM_152419
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379644 ENST00000517319 ENST00000520704 ENST00000522082 ENST00000524016
    ENST00000521576 ENST00000519000 ENST00000520678 ENST00000523989 ENST00000519705
    ENST00000458501(uc003xpx.4) ENST00000297798
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HGSNAT:
    hsa-miR-3164 hsa-miR-623 hsa-miR-3938 hsa-miR-224 hsa-miR-204 hsa-miR-211
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    Additional mRNA sequence: 

    AK025895.1 AK057293.1 AK074839.1 AK304441.1 AK308922.1 AL355714.1 AL832870.1 BC012452.1 
    BC042037.1 BC050672.1 BC056149.1 CR457352.1 CR749838.1 

    19 DOTS entries:

    DT.443544  DT.451524  DT.101984185  DT.100686948  DT.408044  DT.92452256  DT.95073394  DT.100643187 
    DT.121490772  DT.100787696  DT.121490787  DT.70104568  DT.121490711  DT.121490780  DT.86849721  DT.92020733 
    DT.92452257  DT.95360470  DT.95365032 

    24/252 AceView cDNA sequences (see all 252):

    T07847 BU616317 BX090425 AA782526 AW328331 AI686960 AA778199 BF056807 
    H15830 AA749376 BX115923 BC012452 AL707739 BU684026 AW865678 AA113443 
    BM785837 BM720292 AI286326 AI394146 BM676777 BQ002264 BM997097 BP356612 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HGSNAT expression in normal human tissues (normalized intensities)      HGSNAT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCAAACA
    HGSNAT Expression
    About this image


    HGSNAT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles

    See HGSNAT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HGSNAT

    SOURCE GeneReport for Unigene cluster: Hs.600384

    UniProtKB/Swiss-Prot: HGNAT_HUMAN, Q68CP4
    Tissue specificity: Widely expressed, with highest level in leukocytes, heart, liver, skeletal muscle, lung,
    placenta and liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HGSNAT gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hgsnat1 , 5 heparan-alpha-glucosaminide N-acetyltransferase1, 5 81.49(n)1
    82.34(a)1
      8 (14.22 cM)5
    521201  NM_029884.11  NP_084160.11 
     259444595 
    chicken
    (Gallus gallus)
    Aves HGSNAT1 heparan-alpha-glucosaminide N-acetyltransferase 65.35(n)
    63.17(a)
      422490  XM_420455.3  XP_420455.3 
    lizard
    (Anolis carolinensis)
    Reptilia HGSNAT6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    6(58874172-58911017)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BQ389315.12   -- 73.47(n)    BQ389315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-192p21.61 si:dkey-192p21.6 54.25(n)
    47.38(a)
      565246  NM_001145587.1  NP_001139059.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69031 CG6903 48.13(n)
    41.1(a)
      31423  NM_131970.1  NP_572198.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G277301 heparan-alpha-glucosaminide N-acetyltransferase 44.3(n)
    34.2(a)
      832835  NM_122655.3  NP_568500.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g09311001 hypothetical protein 43.24(n)
    30.92(a)
      4326815  NM_001051829.1  NP_001045294.1 


    ENSEMBL Gene Tree for HGSNAT (if available)
    TreeFam Gene Tree for HGSNAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HGSNAT gene
    18 SIMAP similar genes for HGSNAT using alignment to 9 protein entries:     HGNAT_HUMAN (see all proteins):
    FLJ32731    NSD1    SCLT1    WDR6    CNOT2    SENP7
    KLHDC1    ZNF738    ZNF415    BCL2L13    COX7A2    FANCA
    IFT122    SPSB4    BUB1B    SERF1B    ATL2    SUN3

    HGSNAT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    931/1234 SNPs in HGSNAT are shown (see all 1234)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0639894
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639892 R H mis40--------
    VAR_0300904
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0300902 P L mis40--------
    VAR_0300864
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0300862 E K mis40--------
    VAR_0639924
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639922 G E mis40--------
    VAR_0639864
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639862 I R mis40--------
    VAR_0639834
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639832 C F mis40--------
    VAR_0300834
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0300832 P L mis40--------
    VAR_0639944
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639942 S F mis40--------
    VAR_0639934
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639932 A E mis40--------
    VAR_0300854
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0300852 G S mis40--------
    VAR_0300874
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0300872 M K mis40--------
    VAR_0639874
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639872 G R mis40--------
    VAR_0300894
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0300892 D V mis40--------
    VAR_0639904
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639902 W C mis40--------
    VAR_0639964
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639962 S C mis40--------
    VAR_0300884
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0300882 S L mis40--------
    VAR_0639844
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639842 L P mis40--------
    VAR_0639884
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0639882 N K mis40--------
    VAR_0300844
    Mucopolysaccharidosis 3C (MPS3C)4--see VAR_0300842 R C mis40--------
    VAR_0639914
    ----see VAR_0639912 V L mis40--------
    VAR_0639854
    ----see VAR_0639852 P Q mis40--------
    rs1845864871,2
    --42993601(+) CAACAC/TGCCAG 1 -- us2k10--------
    rs1893489581,2
    --42993633(+) CATTCA/GGACTT 1 -- us2k10--------
    rs347428821,2
    C,F--42993756(+) TCTGTT/CGCCCA 1 -- us2k14Minor allele frequency- C:0.38NA 8
    rs1819626061,2
    --42994049(+) GGTACG/TTGCCA 1 -- us2k10--------
    rs1482003801,2
    --42994062(+) ACGCCC/TGGCTA 1 -- us2k10--------
    rs1410888121,2
    C--42994150(+) CCTGCC/TTTGGC 1 -- us2k10--------
    rs1843703421,2
    --42994155(+) CTTGGC/TCTCCC 1 -- us2k10--------
    rs1124662311,2
    C,F--42994162(+) TCCCAG/AAGTGC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1389614911,2
    --42994178(+) TTACAA/GGCGTG 1 -- us2k10--------
    rs1890735461,2
    --42994201(+) CGGCCA/CTATGT 1 -- us2k10--------
    rs1165443821,2
    C,F--42994224(+) AGTTTC/GTCTCT 1 -- us2k10--------
    rs1863047291,2
    --42994251(+) TCAAAC/GGGTCA 1 -- us2k10--------
    rs1899653381,2
    --42994267(+) CTGGAA/GGCTCG 1 -- us2k10--------
    rs799356281,2
    C--42994299(+) GCACCC/GTTAGA 1 -- us2k10--------
    rs1180523541,2
    C,F--42994349(+) CAGTGC/GCCCCT 1 -- us2k11Minor allele frequency- G:0.05NA 120
    rs1420935951,2
    --42994392(+) CCCTAG/TTCTTA 1 -- us2k10--------
    rs1807673611,2
    --42994398(+) TCTTAC/TCCTAG 1 -- us2k10--------
    rs774301941,2
    F--42994587(+) TGAGGG/TGGGAA 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs1851435251,2
    --42994655(+) TACACA/CCAATA 1 -- us2k10--------
    rs45233001,2
    C,F,A,H--42994883(+) CTTGTC/GTTTTG 1 -- us2k115Minor allele frequency- G:0.26NS EA NA WA CSA 791
    rs1463672061,2
    --42994981(+) TTGACA/TAGGTT 1 -- us2k10--------
    rs736291981,2
    C,F--42995047(+) CGATAG/ATGTCT 1 -- us2k12Minor allele frequency- A:0.09WA 120
    rs1381901521,2
    --42995193(+) AACGCC/TTTGGG 1 -- us2k10--------
    rs1406920131,2
    C--42995420(+) CTCGG-/CTTCTTTC 1 -- us2k10--------
    rs1495961921,2
    --42995466(+) GCCCGA/GCCCAG 1 -- us2k10--------
    rs1907380101,2
    --42995579(+) TCCGCA/GGCGGA 1 -- us2k10--------
    rs1442254381,2
    --42995789(+) CGGCCC/GGCTAC 1 -- int10--------
    rs625176101,2
    C,F--42995811(+) CTCCTC/TTCCGC 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1832475831,2
    --42995978(+) GGGCGG/TTTCGG 1 -- int10--------
    rs625176261,2
    C,F--42996090(+) GGGACC/TCCACA 1 -- int12Minor allele frequency- T:0.08NA 122
    rs1445151241,2
    --42996153(+) CCTGCA/GCCCAG 1 -- int10--------
    rs1474194451,2
    --42996351(+) GGTGGC/GGGCGC 1 -- int10--------
    rs1133905531,2
    C,F--42996555(+) ATTGCA/GCAACT 1 -- int12Minor allele frequency- G:0.08WA 120
    rs1864443711,2
    --42996602(+) AAATAC/GAGATT 1 -- int10--------
    rs1915412461,2
    --42996622(+) CATCTA/GGACCC 1 -- int10--------
    rs1397794791,2
    C--42996734(+) TCACCC/TGTCTT 1 -- int10--------
    rs1838004131,2
    --42996853(+) GAATTC/TTGGAA 1 -- int10--------
    rs1878899901,2
    --42996946(+) AGGACC/TCCGGG 1 -- int10--------
    rs117797201,2
    H--42996952(+) CCGGGG/AAGGTT 1 -- int14Minor allele frequency- A:0.00NS EA 404
    rs1929538021,2
    --42997006(+) GAACAC/TTCTTT 1 -- int10--------
    rs1824150291,2
    --42997045(+) AAGGGC/TACTTA 1 -- int10--------
    rs1452025061,2
    --42997087(+) TCACAC/TGTAGT 1 -- int10--------
    rs1868205231,2
    --42997268(+) GATAAC/TTCACG 1 -- int10--------
    rs1177435921,2
    F--42997518(+) AAGCTG/AAACAT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs2010354941,2
    --42997653(+) AAGTG-/AAAAAA 1 -- int10--------
    rs1509902741,2
    C--42997662(+) AAAAAA/TGGTGT 1 -- int10--------
    rs1407643141,2
    --42997704(+) TAGCTA/GTGGTT 1 -- int10--------
    rs590374941,2
    C--42997744(+) ACACTC/TGAATC 1 -- int14Minor allele frequency- T:0.10WA NA EA 360
    rs1497010771,2
    --42997787(+) TTAAAA/GAAATC 1 -- int10--------
    rs1454546811,2
    --42997796(+) TCATGC/GTGATT 1 -- int10--------
    rs1402585381,2
    --42997813(+) AGATTC/TTGATT 1 -- int10--------
    rs1923496331,2
    --42997928(+) TCCCAA/GATAGC 1 -- int10--------
    rs2011514401,2
    --42998221(+) GAAAA-/AGAACTA 1 -- int10--------
    rs1452451991,2
    --42998329(+) AAGGTC/GGTTAA 1 -- int10--------
    rs1848921641,2
    --42998421(+) ACAAAC/TTCAAA 1 -- int10--------
    rs736292011,2
    C--42998639(+) CTCAGA/GTGCCT 1 -- int12Minor allele frequency- G:0.06WA 120
    rs69840211,2
    C--42998669(+) CAGGAC/GCTAtt 1 -- int10--------
    rs1389933401,2
    --42998688(+) TCTTTC/TTTTTT 1 -- int10--------
    rs1928654421,2
    --42998809(+) CCGAGA/TAGCTG 1 -- int10--------
    rs1853803651,2
    --42999037(+) TTGGTA/GAGTGT 1 -- int10--------
    rs1894408131,2
    --42999174(+) TTTTAC/GTCTTG 1 -- int10--------
    rs1155894971,2
    C--42999187(+) CCCGGC/TGTGGT 1 -- int10--------
    rs1437484041,2
    --42999228(+) GAGGTC/TGAGGT 1 -- int10--------
    rs1848963171,2
    --42999266(+) GAGACC/TAGCCT 1 -- int10--------
    rs1418875741,2
    --42999558(+) GATCAC/GTGTAA 1 -- int10--------
    rs1502318731,2
    --42999622(+) TTTAGA/CTTTCC 1 -- int10--------
    rs1881456461,2
    --42999631(+) CCCAAC/TGGTTT 1 -- int10--------
    rs47368441,2
    C,F,A,H--43000026(+) ACTTAT/CACCAG 1 -- int126Minor allele frequency- C:0.19NS EA NA WA CSA 2348
    rs1810011011,2
    C--43000097(+) AGTAAA/GTGTTC 1 -- int10--------
    rs11299871,2
    C,F,A,H--43000187(-) CTGTGG/AGGCTG 1 -- int115Minor allele frequency- A:0.35NS NA WA CSA EA 501
    rs760835621,2
    C--43000236(+) CTTTGA/GGAAGA 1 -- int10--------
    rs1861966381,2
    --43000292(+) TAAACA/GTTAAA 1 -- int10--------
    rs1429589671,2
    --43000426(+) TCTGTC/TGTTAG 1 -- int10--------
    rs1474618681,2
    --43000584(+) GGTAAA/GGTAAG 1 -- int10--------
    rs1924109731,2
    --43000602(+) TAAAAA/GTGAGG 1 -- int10--------
    rs1833147261,2
    --43000724(+) CCCCGC/TCACTA 1 -- int10--------
    rs1870227271,2
    --43000748(+) AATTAA/GCTGGG 1 -- int10--------
    rs1910093011,2
    --43000823(+) CGAGTG/TGTAGA 1 -- int10--------
    rs1826804131,2
    --43000850(+) GATCGC/TGCCAC 1 -- int10--------
    rs1873294031,2
    --43000856(+) GCCACC/TGCACT 1 -- int10--------
    rs715235101,2
    C,F--43000858(+) CACTGC/TACTCC 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1913772041,2
    --43000895(+) TTTAAA/CAAAAA 1 -- int10--------
    rs756886431,2
    F--43001243(+) CAGCAC/TATCAT 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1437632431,2
    --43001285(+) GATTGA/GGGCAT 1 -- int10--------
    rs1824079481,2
    --43001440(+) ATAGAA/GAGCAG 1 -- int10--------
    rs1486745391,2
    --43001546(+) CTACAA/GTCGCA 1 -- int10--------
    rs1421114311,2
    --43001555(+) CAGCTC/GAGTAA 1 -- int10--------
    rs1877912521,2
    --43001562(+) GTAACG/TTGGTA 1 -- int10--------
    rs1511568941,2
    --43001667(+) AGAGGC/GTTAAT 1 -- int10--------
    rs1392074561,2
    --43001725(+) TTATTA/GTAGGG 1 -- int10--------
    rs1932705961,2
    --43001790(+) TTACAC/TGATCC 1 -- int10--------
    rs1850166771,2
    --43001847(+) AGAGAC/TATCTG 1 -- int10--------
    rs587330091,2
    C--43001927(+) ATATA-/TCTGCG 1 -- int10--------
    rs2005299721,2
    F--43002053(+) GTGCCT/CTTTTT 1 -- int11Minor allele frequency- C:0.02EU 571
    rs2006895981,2
    --43002147(+) TCATCC/TATAAT 2 H Y mis10--------
    rs1998163651,2
    C--43002176(+) TTGACC/TGTCTA 2 T syn10--------
    rs2020012451,2
    C--43002177(+) TGACCA/GTCTAC 2 I V mis10--------
    rs1464295231,2
    C,F--43002220(+) CAGTTC/GACACT 1 -- int11Minor allele frequency- G:0.01EU 569
    rs2010430281,2
    --43002240(+) TTGCTC/TTGGGG 1 -- int10--------
    rs1504938401,2
    --43002388(+) AGCATC/TTATTT 1 -- int10--------
    rs1166434381,2
    F--43002396(+) TTTTTA/GTCTTT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs736754581,2
    C,F--43002537(+) ATTCTC/TCAGGG 1 -- int12Minor allele frequency- T:0.09WA 120
    rs1129057111,2
    F--43002614(+) AAATGG/CATTTT 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1491792741,2
    --43002671(+) CAAGGC/TTATTC 1 -- int10--------
    rs1171853131,2
    C,F--43002840(+) AAGCAT/CTGGGT 1 -- int11Minor allele frequency- C:0.04NA 120
    rs1129688081,2
    C,F--43002849(+) GTACTC/TATGAA 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs1886760511,2
    --43002851(+) ACTTAC/TGAACA 1 -- int10--------
    rs1391080671,2
    --43003212(+) GAAACC/GCTGTC 1 -- int10--------
    rs117774081,2
    H--43003405(+) aaaaaA/TTTTTT 1 -- int1 trp30--------
    rs726472971,2
    --43003406(+) AAAAAA/TTTTTA 1 -- int10--------
    rs1929970871,2
    --43003541(+) GCTGTC/TGTCAA 1 -- int10--------
    rs1144612441,2
    F--43003544(+) GTCGTC/GAAGGT 1 -- int11Minor allele frequency- G:0.04WA 118
    rs43870191,2
    C,A,H--43003893(+) atcgcG/Accatt 1 -- int15Minor allele frequency- A:0.10NA CSA 10
    rs123343551,2
    --43003923(+) aagagC/Tgaaac 1 -- int10--------
    rs1113395981,2
    C,F--43004025(+) GGGTGG/ACCTAG 1 -- int12Minor allele frequency- A:0.10CSA WA 120
    rs1437196861,2
    --43004028(+) TGGCCA/TAGTGG 1 -- int10--------
    rs1506007531,2
    C--43004183(+) AACCCC/TGGGAG 1 -- int10--------
    rs1488784921,2
    C--43004261(+) TCAAA-/AAAT  
            
    AAATA
    1 -- int10--------
    rs671218161,2
    C--43004262(+) CAAAA-/AAAT  
            
    AATAA
    1 -- int10--------
    rs572405071,2
    C--43004264(+) ATAAA-/TAAA  
            
    GGAAT
    1 -- int10--------
    rs1839550011,2
    --43004332(+) ATTGCC/TGATTT 1 -- int10--------
    rs736315611,2
    C,F--43004414(+) ATAGTG/AGTAGA 1 -- int12Minor allele frequency- A:0.04WA 120
    rs1886800751,2
    --43004421(+) TAGAAA/GATATC 1 -- int10--------
    rs2015760381,2
    --43004519(+) TAAAC-/TGTTTTA 1 -- int10--------
    rs1396225801,2
    --43004534(+) TTGAAA/CTTTAA 1 -- int10--------
    rs1807625261,2
    --43004598(+) GCACTC/G/TTGGGA 1 -- int10--------
    rs1836884401,2
    --43004612(+) CGAGGC/TGGGCG 1 -- int10--------
    rs1492867811,2
    --43004638(+) AGATCA/GAGACC 1 -- int10--------
    rs1902446091,2
    C--43004729(+) TCCCAC/GCTACT 1 -- int10--------
    rs1824219031,2
    --43004759(+) AATGGA/CGTGAA 1 -- int10--------
    rs1865411721,2
    --43004765(+) GTGAAC/TCCGGG 1 -- int10--------
    rs602597661,2
    --43004803(+) GGGCCA/GCTGTA 1 -- int10--------
    rs1817210811,2
    C--43004931(+) AACTTA/CATACA 1 -- int10--------
    rs1856280971,2
    --43004981(+) GGATAG/TCTTTA 1 -- int10--------
    rs1416446841,2
    C--43005097(+) TTTAT-/TTTA  
            
    TTTAT
    1 -- int10--------
    rs1903427311,2
    --43005138(+) TCTGTC/TGCCCA 1 -- int10--------
    rs1821495951,2
    --43005162(+) TGGCAC/TGATCT 1 -- int10--------
    rs69934571,2
    A--43005170(+) tctcaC/Gctcac 1 -- int10--------
    rs1445557761,2
    --43005225(+) CTCCCA/GAGTAG 1 -- int10--------
    rs69936151,2
    C,F,A--43005246(+) aggcgT/Cccgcc 1 -- int15Minor allele frequency- C:0.33WA NA CSA 9
    rs1879108571,2
    --43005249(+) CGCCCA/GCCACC 1 -- int10--------
    rs1918034261,2
    --43005261(+) CACCCA/GGTAAT 1 -- int10--------
    rs1840415781,2
    --43005264(+) CCAGTA/GATTTT 1 -- int10--------
    rs1889374781,2
    --43005457(+) TGTATC/TTTTAA 1 -- int10--------
    rs1440590411,2
    --43005504(+) TAGTTC/GACACC 1 -- int10--------
    rs753727351,2
    C,F--43005506(+) GTTCAC/TACCTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1920290611,2
    --43005659(+) AAAAAG/TAAAAG 1 -- int10--------
    rs1844324071,2
    --43005702(+) CCAGGC/TGCGGT 1 -- int10--------
    rs1869017431,2
    --43005772(+) GAGATC/GGAGAC 1 -- int10--------
    rs1917428501,2
    C--43005787(+) CTGGCC/TAACAC 1 -- int10--------
    rs1834804631,2
    --43005792(+) CAACAC/TGGTGA 1 -- int10--------
    rs1894622121,2
    --43005793(+) AACACA/GGTGAA 1 -- int10--------
    rs1810475941,2
    --43005894(+) ATGGCA/GTGAAC 1 -- int10--------
    rs1856406351,2
    --43005901(+) GAACCC/TGGGAG 1 -- int10--------
    rs1905085591,2
    --43005902(+) AACCCA/GGGAGG 1 -- int10--------
    rs561837951,2
    --43005920(+) TGCAAA/GGAGCC 1 -- int10--------
    rs1861633731,2
    C--43005939(+) GCCACG/TGCACT 1 -- int10--------
    rs1900925271,2
    --43005964(+) AGAGCG/TAGACT 1 -- int10--------
    rs1442666841,2
    C--43005978(+) TTTCA-/AAAT  
            
    AAATA
    1 -- int10--------
    rs3710459331,2
    C--43006005(+) TAAAT-/AAAATA 1 -- int10--------
    rs2021328851,2
    --43006041(+) AGAGC-/TATATAT 1 -- int10--------
    rs2017095441,2
    --43006081(+) CTAAA-/ATAT  
            
    ATATT
    1 -- int10--------
    rs1812920891,2
    --43006134(+) AGTAGA/CTATTA 1 -- int10--------
    rs46234741,2
    C,F,A,H--43006229(+) TTTATA/GTGGGT 1 -- int123Minor allele frequency- G:0.30NS EA NA WA CSA 2350
    rs1464205481,2
    --43006306(+) TGATAA/TGATAC 1 -- int10--------
    rs1865311681,2
    --43006508(+) GGAAAA/TATAAC 1 -- int10--------
    rs1909945091,2
    --43006538(+) CTTGGC/GAGTGT 1 -- int10--------
    rs612558361,2
    C,F--43006588(+) CTCTCC/TACGTG 1 -- int11Minor allele frequency- T:0.20WA 118
    rs1398378251,2
    C--43006625(+) TAACAC/TGTGTG 1 -- int10--------
    rs340342301,2
    C--43006671(+) ATTCCT/CGTATA 1 -- int12Minor allele frequency- C:0.25NA 4
    rs1420634681,2
    C--43006719(+) AAAGAA/GACTGG 1 -- int10--------
    rs1511059141,2
    --43006827(+) ATTTCA/GTTGAA 1 -- int10--------
    rs764313421,2
    --43006975(+) CTTACA/GACACT 1 -- int10--------
    rs1498180651,2
    C--43007223(+) AGGTTA/GGGAGT 1 -- int10--------
    rs751101181,2
    C--43007240(+) ACCAGC/GCTGAC 1 -- int10--------
    rs789880131,2
    C--43007241(+) CCAGCC/GTGACC 1 -- int10--------
    rs1479384211,2
    C--43007326(+) TTACTC/TGGGAG 1 -- int10--------
    rs1416357341,2
    C--43007361(+) CCTGGG/TAGGCG 1 -- int10--------
    rs1827121261,2
    --43007591(+) GCTGAG/TAAATG 1 -- int10--------
    rs1168701681,2
    C,F--43007630(+) TCTGTT/CGCCCA 1 -- int11Minor allele frequency- C:0.02EA 120
    rs1470722601,2
    --43007716(+) AGCCTC/TTCAAG 1 -- int10--------
    rs1889658541,2
    --43007911(+) ATACAC/TTTAAA 1 -- int10--------
    rs757924561,2
    F--43008047(+) TCATTA/CTATAG 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1909780391,2
    --43008274(+) AGGCCA/GTAATC 1 -- int10--------
    rs1382896901,2
    --43008281(+) AATCGC/TTTATG 1 -- int10--------
    rs356125091,2
    C--43008502(+) AAAAG-/TTTTTT 1 -- int10--------
    rs712318941,2
    C--43008503(+) TTTTAT/-ATTGA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1827606421,2
    --43008547(+) GGGTAC/TAGTAT 1 -- int10--------
    rs1179943201,2
    F--43008638(+) GCCAAT/GGTACA 1 -- int11Minor allele frequency- G:0.03NA 120
    rs752203801,2
    C--43008642(+) ATGTAC/TACGTT 1 -- int10--------
    rs1432418091,2
    C--43008644(+) GTACAC/TGTTGG 1 -- int10--------
    rs743493191,2
    F--43008691(+) CCAAAA/GCACTT 1 -- int11Minor allele frequency- G:0.03EA 120
    rs1874014731,2
    --43008787(+) CTACTA/GTGCCA 1 -- int10--------
    rs1482635461,2
    --43008884(+) TTTACC/TCTCTA 1 -- int10--------
    rs1413712591,2
    --43008927(+) ACGAGA/TGAGAT 1 -- int10--------
    rs109587371,2
    C,F,A,H--43009057(+) ctgtgC/Aatata 1 -- int111Minor allele frequency- A:0.28NA WA CSA EA 372
    rs1914824451,2
    --43009073(+) CATTTC/TTTTGT 1 -- int10--------
    rs1462364831,2
    --43009090(+) ATCGGC/TTGATG 1 -- int10--------
    rs1398851451,2
    C--43009195(+) TTTTC-/TTTTTT 1 -- int10--------
    rs1832566351,2
    --43009255(+) AGGGGA/GCTGCT 1 -- int10--------
    rs1997252311,2
    --43009337(+) ATTAC-/TTTTTT 1 -- int10--------
    rs1881288951,2
    --43009369(+) TTTAGA/GGTACA 1 -- int10--------
    rs1926560091,2
    --43009380(+) TGTGCA/GCAATG 1 -- int10--------
    rs1380699811,2
    C--43009509(+) CAGGTC/TCTGGT 1 -- int10--------
    rs1844436911,2
    --43009582(+) AGCACA/GCGGTG 1 -- int10--------
    rs1995529251,2
    --43009682(+) TTATC-/GCTGCC 1 -- int10--------
    rs1905091571,2
    --43009687(+) GCTGCA/CTAGTA 1 -- int10--------
    rs1925536651,2
    C--43009912(+) CACACC/TGACTT 1 -- int10--------
    rs1424531711,2
    --43010031(+) TCTAAC/TTGGTG 1 -- int10--------
    rs1133456521,2
    C,F--43010126(+) CATAAT/ATGTCT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1843657571,2
    --43010170(+) CACTTG/TTTGAT 1 -- int10--------
    rs1890635911,2
    --43010279(+) TTTTAA/GTTTTT 1 -- int10--------
    rs1398713651,2
    --43010304(+) TGTTTA/CCCACA 1 -- int10--------
    rs1817332661,2
    --43010531(+) TTCCCC/GTGATA 1 -- int10--------
    rs754290451,2
    C,F--43010634(+) GTTCCT/CTATAT 1 -- int12Minor allele frequency- C:0.07WA 120
    rs1864486951,2
    --43010805(+) TTTCCC/TCCATG 1 -- int10--------
    rs1151197661,2
    F--43010870(+) TTTGAG/CTTGGT 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1496580921,2
    --43010888(+) AGATAA/TGAGAG 1 -- int10--------
    rs1444544341,2
    --43010894(+) GAGAGA/TTAGGG 1 -- int10--------
    rs1897076791,2
    --43011065(+) TGCAGC/GCTCTG 1 -- int10--------
    rs1807626791,2
    --43011156(+) TTTTGC/TATTTT 1 -- int10--------
    rs120566061,2
    C,A--43011302(+) tgtagG/Acattt 1 -- int112Minor allele frequency- A:0.17NA WA CSA EA 375
    rs1487921091,2
    --43011363(+) TTGGAA/GTGTTG 1 -- int10--------
    rs1137638391,2
    C--43011517(+) CATCTC/TGGCTC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1479268451,2
    C--43011518(+) ATCTCA/GGCTCA 1 -- int10--------
    rs1417993761,2
    C--43011569(+) TCAGCC/TTCCCA 1 -- int10--------
    rs1860156451,2
    --43011787(+) CTTGTG/TTGCTC 1 -- int10--------
    rs1455551421,2
    --43011861(+) TTATAA/TCTGTT 1 -- int10--------
    rs1907296461,2
    --43012021(+) TTTTCC/TATCCC 1 -- int10--------
    rs1832383431,2
    --43012303(+) ATGAGA/GACATA 1 -- int10--------
    rs119951111,2
    C,F,H--43012445(+) ATCTAG/CTAACT 1 -- int15Minor allele frequency- C:0.05NA WA 126
    rs1154900191,2
    C,F--43012514(+) AATTTG/TATTTA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1864394741,2
    --43012546(+) TGTAAC/TGGGAG 1 -- int10--------
    rs1904511381,2
    --43012547(+) GTAACA/GGGAGC 1 -- int10--------
    rs1835684121,2
    --43012566(+) TGACTA/GTTTTT 1 -- int10--------
    rs1476824591,2
    --43012587(+) AATCTC/TACCCT 1 -- int10--------
    rs351534151,2
    C--43012634(+) GAACCT/-TTGGC 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1113522681,2
    C--43012637(+) ACCTTT/GGCCAG 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1881617131,2
    --43012782(+) TGGGCA/GTAGTG 1 -- int10--------
    rs1927421081,2
    --43013137(+) TTAAAA/TTTATG 1 -- int10--------
    rs736315691,2
    C,F--43013143(+) TTATGC/GAAGAC 1 -- int12Minor allele frequency- G:0.07WA 120
    rs1409981971,2
    --43013180(+) ACTTAC/TTGATT 1 -- int10--------
    rs119936471,2
    H--43013335(+) ctcccG/Tggttc 1 -- int10--------
    rs1826528211,2
    --43013369(+) CCCAAA/GTAGCT 1 -- int10--------
    rs1868117561,2
    --43013414(+) TTTTTA/GTATTT 1 -- int10--------
    rs117819791,2
    H--43013440(+) gtttcA/Cccatg 1 -- int10--------
    rs1501855501,2
    C--43013546(+) CAGTCA/TTTGTT 1 -- int10--------
    rs1916086731,2
    --43013548(+) GTCATA/TGTTTT 1 -- int10--------
    rs1172567801,2
    C,F--43013643(+) AGTTGG/AATATT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1387364001,2
    --43013811(+) GATCTA/GTCCTG 2 I V mis10--------
    rs1848839371,2
    C--43013825(+) CTGAAC/TGACAC 2 N syn10--------
    rs2000792401,2
    --43013843(+) GAGAAA/GGAAGT 2 K syn10--------
    rs109587381,2
    C,F,A,H--43013936(+) CTTTAT/CAGTAT 1 -- int123Minor allele frequency- C:0.32NS EA WA NA CSA 2351
    rs1488988041,2
    --43013964(+) GGTCCA/GTACCC 1 -- int10--------
    rs1456099131,2
    --43014000(+) TGATAC/TTAGCA 1 -- int10--------
    rs726473001,2
    --43014013(+) ATCCAA/GCTTCT 1 -- int10--------
    rs1896013911,2
    C,F--43014032(+) AATCTA/GACCAC 1 -- int11Minor allele frequency- G:0.01EU 579
    rs1930664511,2
    C--43014188(+) CCTTCA/GTACGT 1 -- spd10--------
    rs2016889371,2
    --43014200(+) TATGTA/TCTCTG 1 -- int10--------
    rs726473021,2
    C,F--43014233(+) CAGAGG/TTTTCA 1 -- int12Minor allele frequency- T:0.05NA EU 689
    rs1381313141,2
    C--43014277(+) CATGAC/TGCTTT 1 -- int10--------
    rs1852526941,2
    --43014295(+) TGAAAA/CCCTAA 1 -- int10--------
    rs736315731,2
    C--43014307(+) TCTTAG/AGTCAT 1 -- int12Minor allele frequency- A:0.09WA 120
    rs1897069721,2
    --43014515(+) CACTCA/GAGCTC 1 -- int10--------
    rs1813037781,2
    --43014534(+) GAGACA/GAGCCT 1 -- int10--------
    rs1425198891,2
    --43014874(+) AGGAGC/TGAGCG 1 -- int10--------
    rs1858938371,2
    --43014878(+) GTGAGC/GGTATA 1 -- int10--------
    rs736754591,2
    C,F--43015023(+) CTTTTG/AAAAGG 1 -- int12Minor allele frequency- A:0.04WA 120
    rs1460046301,2
    C--43015410(+) ATTCTA/GTGGAG 1 -- int10--------
    rs1145731691,2
    F--43015459(+) ATGTCG/ACAACC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1482132381,2
    --43015543(+) TTTACC/TAGCTG 1 -- int10--------
    rs1881342661,2
    --43015576(+) CAACCA/GCAACA 1 -- int10--------
    rs1445989301,2
    C--43015682(+) TGAAA-/TAGTTT
            
    TAGAT
    1 -- int10--------
    rs1809888911,2
    --43015734(+) TTCACC/TTAGCT 1 -- int10--------
    rs1861845971,2
    --43015739(+) TTAGCG/TTCCCC 1 -- int10--------
    rs1909915311,2
    --43015824(+) TTAACA/GTTGAA 1 -- int10--------
    rs1835454971,2
    --43015891(+) TAATAC/TCCTTC 1 -- int10--------
    rs1868037251,2
    --43015938(+) TTTAGC/GTTTCA 1 -- int10--------
    rs1912460651,2
    --43016033(+) TGGTTA/GTTTTG 1 -- int10--------
    rs1412201771,2
    --43016089(+) ATGAAC/TAGGTA 1 -- int10--------
    rs44079241,2
    C,F,A,H--43016160(+) tgtgtC/Gaggag 1 -- int119Minor allele frequency- G:0.01NS EA NA WA CSA 817
    rs1829955231,2
    C--43016668(+) GGGAGA/GACGCC 1 -- int10--------
    rs736754601,2
    C--43016700(+) AATAAC/TACATT 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1175624691,2
    F--43016946(+) TTTAAC/TGAGCA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1507154501,2
    --43016984(+) AGGTCA/GCTGCA 1 -- int10--------
    rs1390630401,2
    --43017008(+) CCCCTC/TTCTGG 1 -- int10--------
    rs1498501231,2
    --43017180(+) CTCTGC/TGTGGT 1 -- int10--------
    rs736754611,2
    C,F--43017181(+) TCTGCG/ATGGTG 1 -- int12Minor allele frequency- A:0.09WA 120
    rs1873232621,2
    --43017184(+) GCGTGG/TTGAAT 1 -- int10--------
    rs759781281,2
    F--43017287(+) TTTTAA/GAAAGA 1 -- int11Minor allele frequency- G:0.04NA 120
    rs1897906931,2
    --43017294(+) AAGAAA/TAAGAG 1 -- int10--------
    rs1475234901,2
    --43017364(+) GAGCAA/GTATCC 1 -- int10--------
    rs1824018821,2
    --43017389(+) AAAACC/GTAACC 1 -- int10--------
    rs1401982891,2
    --43017403(+) AAGTCA/GGCTAG 1 -- int10--------
    rs1877869131,2
    --43017602(+) ATTTCC/TTTGAG 1 -- int10--------
    rs1931140491,2
    --43017688(+) TGGATC/TTATTA 1 -- int10--------
    rs345685551,2
    C--43017697(+) ATGGAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1851196611,2
    --43017775(+) CTGCAG/TCCTTG 1 -- int10--------
    rs1883840641,2
    --43017835(+) GACTAC/GAGGCA 1 -- int10--------
    rs354449911,2
    C,F--43017884(+) ATTTTT/CGTATT 1 -- int15Minor allele frequency- C:0.09NA 128
    rs1932003041,2
    --43017913(+) TTGATA/GTGTTG 1 -- int10--------
    rs1839458321,2
    --43017922(+) TGCCCA/TGGCTG 1 -- int10--------
    rs1886688521,2
    --43017941(+) CTCCTC/GGACTC 1 -- int10--------
    rs1807523921,2
    --43017962(+) TCTGTC/TTCTGA 1 -- int10--------
    rs117816111,2
    C,H--43018192(+) gtgtgA/Ctggtg 1 -- int10--------
    rs577985711,2
    C,F--43018242(+) AAAATG/TGCTTG 1 -- int12Minor allele frequency- T:0.11WA 120
    rs1999873841,2
    --43018330(+) TCAAG-/AAAAAA 1 -- int10--------
    rs798618901,2
    C,F--43018339(+) AAAAAA/GGTAAT 1 -- int13Minor allele frequency- G:0.11WA NA 122
    rs1177848381,2
    C,F--43018358(+) GAGATC/AAAGCA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs793406871,2
    C,F--43018359(+) AGATCT/AAGCAT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1836783151,2
    --43018469(+) ACAAAA/GCAGGA 1 -- int10--------
    rs69965141,2
    C,H--43018592(+) ACTTAG/TGCAAC 1 -- int16Minor allele frequency- T:0.00NS EA NA 422
    rs1904845921,2
    --43018653(+) ACTTCC/TCCTTT 1 -- int10--------
    rs1487378431,2
    C--43018774(+) AAGAAA/GTTCTC 1 -- int10--------
    rs1176226221,2
    C,F--43018865(+) CATCTT/CGGCCA 1 -- int11Minor allele frequency- C:0.09EA 120
    rs1821460931,2
    --43019171(+) TGACGA/GTATTA 1 -- int10--------
    rs1876724341,2
    --43019380(+) TGTGTA/CGACAC 1 -- int10--------
    rs1423688761,2
    C--43019436(+) TGTTAC/TTGTGC 1 -- int10--------
    rs1163393231,2
    F--43019459(+) CACTTC/TACAGA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1915455751,2
    C--43019790(+) GTGGCA/GGCGCA 1 -- int10--------
    rs1404217681,2
    C--43019865(+) GTTTGC/TAGTGA 1 -- int10--------
    rs1821208481,2
    --43019928(+) TCAAAA/TAATAA 1 -- int10--------
    rs1457780321,2
    C--43020038(+) GAATG-/AATA  
            
    GAGAG
    1 -- int10--------
    rs1856239661,2
    --43020173(+) GGCATA/GTGCCA 1 -- int10--------
    rs1903363521,2
    --43020305(+) TCTTGA/TCTTTG 1 -- int10--------
    rs1821421391,2
    --43020328(+) GTAATC/TGTTAT 1 -- int10--------
    rs1168781501,2
    C,F--43020358(+) TACTAT/CTATAT 1 -- int11Minor allele frequency- C:0.02NA 120
    rs1868221821,2
    --43020403(+) GCTCCC/TACTGT 1 -- int10--------
    rs559085191,2
    C,F--43020428(+) GCCATG/CAACCC 1 -- int12Minor allele frequency- C:0.08WA 120
    rs3769427291,2
    C--43020491(+) CCACC-/ACTG  
            
    CTGAC
    1 -- int10--------
    rs1456438081,2
    --43020498(+) TGACTA/GTTCCC 1 -- int10--------
    rs614685541,2
    C,F--43020584(+) CTACAG/ATGGCT 1 -- int12Minor allele frequency- A:0.10WA 120
    rs1465082391,2
    --43020799(+) AACAGG/TCTGGG 1 -- int10--------
    rs1920992821,2
    --43020995(+) AATTGC/TTTGAA 1 -- int10--------
    rs1838503471,2
    --43021055(+) GCCTAA/GGCAAA 1 -- int10--------
    rs1892100841,2
    --43021219(+) CAGTTA/CTGTAG 1 -- int10--------
    rs1411388011,2
    --43021348(+) TGCTGA/GTGGAG 1 -- int10--------
    rs1447571471,2
    C--43021429(+) TTCCAG/TGCAGA 1 -- int10--------
    rs1386107541,2
    --43021491(+) GGAAGA/GAGAAT 1 -- int10--------
    rs109587391,2
    C,F,A,H--43021568(+) agccaG/Atgctc 1 -- int110Minor allele frequency- A:0.33NA WA CSA 21
    rs1435211811,2
    --43021625(+) CTCCTC/TTGTCT 1 -- int10--------
    rs787995291,2
    F--43021631(+) TGTCTG/CTGCTC 1 -- int11Minor allele frequency- C:0.02NA 120
    rs1928664981,2
    --43021647(+) ATGGAA/TCAGCA 1 -- int10--------
    rs1480078441,2
    --43021701(+) CTATTC/TTAAGC 1 -- int10--------
    rs108089631,2
    C,F,A,H--43021708(+) aagccC/Tactgt 1 -- int115Minor allele frequency- T:0.13NS NA WA CSA EA 500