HGS Gene
protein-coding GIFtS: 67
GCID: GC17P079651
|
|
hepatocyte growth factor-regulated tyrosine kinase substrate
| |
Aliases
for HGS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate1 2 | | Vps271 | | HRS2 3 5 | | ZFYVE81 | | Hrs1 3 | | Human Growth Factor-Regulated Tyrosine Kinase Substrate2 | | Protein Pp1102 3 | | |
Export aliases for HGS gene to outside databasesPrevious GC identifers: GC17U990142 GC17P080211 GC17P080346 GC17P077261 GC17P075097 |
Summaries
for HGS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HGS:
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradationof membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body,targeting these proteins for lysosome-dependent degradation. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: HGS_HUMAN, O14964Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated withSTAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase invesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin.May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptortyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex bindsubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to furthersequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to theactivin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiproteincomplex required for efficient transferrin receptor recycling but not for EGFR degradation
Gene Wiki entry for HGS
|
Genomic Views
for HGS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HGS gene promoter:
AML1a SREBP-1c Lmo2 AP-4 SREBP-1b C/EBPalpha CP2 SREBP-1a ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for HGS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HGS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25HGS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P079651: view genomic region
(about GC identifiers)
Start:
|
79,650,356 bp from pter |
End:
|
79,670,168 bp from pter |
Size:
|
19,813 bases |
Orientation:
|
plus strand |
|
Proteins
for HGS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HGS_HUMAN, O14964 (See
protein sequence)Recommended Name: Hepatocyte growth factor-regulated tyrosine kinase substrate Size: 777 amino acids; 86192 Da
Subunit: Interacts with TRAK1. Interacts with TRAK2 (By similarity). Interacts with TRAK1. Component of the ESCRT-0complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) andEPS15. Interacts with STAM. Interacts with STAM2. Interacts with EPS15; the interaction is direct, calcium-dependentand inhibited by SNAP25. Interacts with NF2; the interaction is direct. Interacts with ubiquitin; the interaction isdirect. Interacts with VPS37C. Interacts with SMAD1, SMAD2 and SMAD3. Interacts with TSG101; the interaction mediatesthe association with the ESCRT-I complex. Interacts with SNAP25; the interaction is direct and decreases with additionof increasing concentrations of free calcium. Interacts with SNX1; the interaction is direct. Component of a 550 kDamembrane complex at least composed of HGS and SNX1 but excluding EGFR. Component of the CART complex, at leastcomposed of ACTN4, HGS/HRS, MYO5B and TRIM3
Subcellular location: Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome,multivesicular body membrane; Peripheral membrane protein (By similarity)
5 PDB 3D structures from  and Proteopedia  for HGS:2D3G (3D)
3F1I (3D)
3OBQ (3D)
3ZYQ (3D)
4AVX (3D)
Secondary accessions: Q9NR36Alternative splicing: 2 isoforms: O14964-1 O14964-2 (Dubious isoform produced through aberrant splice sites)Explore the universe of human proteins at neXtProt for HGS: NX_O14964
Post-translational modifications:
Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylationoccurs in response to EGF, IL-2, GM-CSF and HGF1
Ubiquitinated by ITCH1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14964
HGS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004703.1
ENSEMBL proteins: ENSP00000459685 ENSP00000331201 ENSP00000458987 ENSP00000458603 ENSP00000458775 ENSP00000460130 ENSP00000458789 ENSP00000460165 Reactome Protein details: O14964
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
HGS for ontologies About GeneDecksing
HGS Antibody Products:
Assay Products for HGS: |
Protein
Domains /
Families
for HGS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HGS for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry O14964ProtoNet protein and cluster: O14964 2 Blocks protein families: IPB000306 Zn-finger IPB002014 VHS
UniProtKB/Swiss-Prot: HGS_HUMAN, O14964Domain: Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helixDomain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes ofearly endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantiallyincreased in acidic conditionsSimilarity: Contains 1 FYVE-type zinc fingerSimilarity: Contains 1 UIM (ubiquitin-interacting motif) repeatSimilarity: Contains 1 VHS domain |
Function
for HGS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HGS_HUMAN, O14964Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated withSTAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase invesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin.May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptortyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex bindsubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to furthersequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to theactivin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiproteincomplex required for efficient transferrin receptor recycling but not for EGFR degradation Genatlas biochemistry entry for HGS:hepatocyte growth factor-regulated tyrosine kinase substrate,inhibiting the cytokine cell growth function induced bySTAM
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HGS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HGS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HGS (NM_004712) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HGS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGS |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
HGS for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for HGS:
Animal Models:
Mouse knock-out Hgstm1Sor for HGS
9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Hgs):
HGS for phenotypes About GeneDecksing
|
Pathways & Interactions
for HGS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | Disease | | | 3 | Membrane Trafficking | | | 4 | Remodeling of Adherens Junctions | | | 5 | TGF-beta Receptor Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HGS
2  GeneGo (Thomson Reuters) Pathways for HGS
4  BioSystems Pathways for HGS
5/7 
Reactome Pathways for HGS (see all 7)
2 
Kegg Pathways (Kegg details for HGS):
HGS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HGS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/200 Interacting proteins for HGS (O149642, 3 ENSP000003312014) via UniProtKB, MINT, STRING, and/or I2D (see all 200)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| UBC | P0CG482, 3, ENSP000003448184 | MINT-50269 MINT-50283 MINT-50292 MINT-50270 MINT-50293 MINT-19113 MINT-50284 MINT-50265 I2D:
score=4 STRING: ENSP00000344818 | | TSG101 | Q998162, 3, ENSP000002519684 | MINT-50310 MINT-50311 MINT-50312 MINT-50313 MINT-68474 I2D:
score=8 STRING: ENSP00000251968 | | CEP55 | Q53EZ42, 3, ENSP000003605404 | MINT-6173401 MINT-6173438 I2D:
score=2 STRING: ENSP00000360540 | | RAB14 | P611062, 3, ENSP000003629464 | MINT-3369773 MINT-3369790 I2D:
score=1 STRING: ENSP00000362946 | | EHMT2 | Q96KQ72, 3, ENSP000003646874 | MINT-66600 I2D:
score=5 STRING: ENSP00000364687 |
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
HGS for ontologies About GeneDecksing
|
Drugs & Compounds
for HGS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HGS for compounds About GeneDecksing
 Browse Tocris compounds for HGS
1 DrugBank Compound for HGS About this table
10/13 Novoseek chemical compound relationships for HGS gene (see all 13) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| propanil |
94 |
51 |
15113837 (8), 20422006 (6), 9407053 (5), 12551915 (3) (see all 19) |
| phosphatidylinositol 3-phosphate |
80 |
7 |
11493665 (3), 10889197 (1), 14618335 (1), 11456498 (1) |
| tyrosine |
74.9 |
139 |
17101784 (4), 9630564 (2), 11003664 (2), 12180964 (2) (see all 81) |
| gefitinib |
55.5 |
4 |
16869787 (1), 16204931 (1), 18379356 (1) |
| erlotinib |
52.1 |
1 |
16869787 (1) |
| mannose 6-phosphate |
50 |
1 |
18031739 (1) |
| wortmannin |
40.2 |
2 |
11003664 (1), 11532964 (1) |
| phosphotyrosine |
29.7 |
1 |
7819083 (1) |
| proline |
28.4 |
3 |
10889197 (1), 17182674 (1) |
| phosphoinositide |
27.8 |
1 |
11456498 (1) |
Search CenterWatch for drugs/clinical trials and news about HGS
|
Transcripts
for HGS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HGS gene: NM_004712.4 Unigene Cluster for HGS: Hepatocyte growth factor-regulated tyrosine kinase substrate Hs.661056 [show with all ESTs]Unigene Representative Sequence: NM_00471217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000571518 ENST00000329138(uc002kbg.3) ENST00000576393 ENST00000576498(uc010wus.2)
ENST00000572392 ENST00000577012 ENST00000576087 ENST00000573080 ENST00000575058
ENST00000571237 ENST00000571885 ENST00000571647 ENST00000573949 ENST00000570355
ENST00000575078 ENST00000573320 ENST00000570652
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HGS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HGS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HGS (NM_004712) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HGS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGS |
Additional cDNA sequence: AF260566.1 AK294190.1 AK303800.1 BC003565.1 BT009754.1 D84064.1 U43895.1 24/32 DOTS entries (see all 32): DT.215617 DT.99958034 DT.100804007 DT.120892426 DT.97821159 DT.65288039 DT.116243 DT.120892488 DT.91801095 DT.97786986 DT.100029956 DT.40110140 DT.120892515 DT.91768738 DT.95165972 DT.97860828 DT.100029957 DT.100785819 DT.91768724 DT.91906655 DT.100009326 DT.100785821 DT.120892411 DT.120892534 24/715 AceView cDNA sequences (see all 715): CA489484 BU154884 AI127960 AI651403 BI222755 CD675019 BF219688 BM911608 AI333275 BI819266 CK903781 AI807809 AW001566 BG287685 CA442381 BM556222 AI499854 BC003565 AI201897 BI083963 CA455421 CD672179 BQ710703 BQ051633
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HGS (see all 11) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18b | · | 18c | ^ | 19 | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | · | 24c | · | 24d |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HGS
|
Expression
for HGS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HGS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HGS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HGS
SOURCE GeneReport for Unigene cluster: Hs.661056
UniProtKB/Swiss-Prot: HGS_HUMAN, O14964Tissue specificity: Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheralblood leukocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including HGS:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HGS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HGS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HGS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HGS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGS |
Orthologs
for HGS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HGS gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for HGS (if available)
TreeFam Gene Tree for HGS (if available) |
Paralogs
for HGS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HGS gene
- WDFY22 WDFY12
3 SIMAP similar genes for HGS using alignment to 8 protein entries: HGS_HUMAN (see all proteins):GGA3 TOM1 GGA1
HGS for paralogs About GeneDecksing
|
Genomic Variants
for HGS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HGS (79650356 - 79670168 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HGS
3 CNVs: 30036 73071 30034 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HGS |
|
Disorders
/ Diseases
for HGS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HGS for disorders About GeneDecksing
OMIM gene information: 604375
OMIM disorders: --
20/22  diseases for HGS (see all 22): About MalaCardspelger-huet anomaly charcot-marie-tooth disease severe combined immunodeficiency combined immunodeficiency
hypertonia chancroid tooth disease neurilemmoma
neurofibromatosis prostate cancer breast cancer immunodeficiency
neurodegeneration lung cancer prostatitis adenoma
ataxia adenocarcinoma carcinoma pancreatitis
1 disease from the University of Copenhagen DISEASES database for HGS:Pelger-Huet anomaly 9 Novoseek disease relationships for HGS gene About this table
Human Genome Epidemiology (HuGE) Navigator: HGS (3 documents)
Export disorders for HGS gene to outside databases
|
Publications
for HGS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HGS gene, integrated from 9 sources (see all 221):
(articles sorted by number of sources associating them with HGS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PubMed id 9407053)1, 2, 3, 9 Asao H.... Sugamura K. (1997)
- Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17. (PubMed id 9630564)1, 2, 3, 9 Lu L....Kitamura N. (1998)
- STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PubMed id 12551915)1, 2, 9 Bache K.G.... Stenmark H. (2003)
- The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. (PubMed id 14602072)1, 2, 9 Marchese A....Benovic J.L. (2003)
- HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. (PubMed id 12900394)1, 2, 9 Pornillos O.... Sundquist W.I. (2003)
- CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. (PubMed id 15772161)1, 2, 9 Yan Q....Bean A.J. (2005)
- Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. (PubMed id 18675823)1, 2 Webber E....Chin L.S. (2008)
- Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. (PubMed id 16462748)1, 2 Hirano S....Wakatsuki S. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PubMed id 15509564)1, 2 Eastman S.W.... Bieniasz P.D. (2005)
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External Searches for HGS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HGS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing HGS gene
(According to HUGE)
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Specialized Databases showing HGS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for HGS gene:
Search GeneIP for patents involving HGS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HGS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for HGS | | OriGene shRNA RFP for HGS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HGS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HGS | | | OriGene Protein Over-expression Lysate for HGS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HGS | | OriGene 3'-UTR Clone for HGS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HGS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HGS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HGS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HGS | | OriGene Custom Protein Services for HGS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HGS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HGS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HGS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HGS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HGS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HGS |
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| | | | Search Tocris compounds for HGS |
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 | | | HGS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGS |
|  |  |  | | | | ThermoFisher Antibodies for HGS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGS |
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