Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HGH1 Gene

Aliases for HGH1 Gene

  • HGH1 Homolog 2 3 5
  • Family With Sequence Similarity 203, Member B 2 3
  • Family With Sequence Similarity 203, Member A 2 3
  • Brain Protein 16 2 3
  • C8orf30A 3 4
  • C8orf30B 3 4
  • FAM203A 3 4
  • FAM203B 3 4
  • Chromosome 8 Open Reading Frame 30A 2
  • Chromosome 8 Open Reading Frame 30B 2
  • HGH1 Homolog (S. Cerevisiae) 2
  • Brain Protein 16-Like 3
  • Protein HGH1 Homolog 3
  • Protein FAM203A 3
  • Protein FAM203B 3
  • BRP16L 3
  • BRP16 3

External Ids for HGH1 Gene

Previous HGNC Symbols for HGH1 Gene

  • C8orf30A
  • FAM203B
  • C8orf30B
  • FAM203A

Summaries for HGH1 Gene

GeneCards Summary for HGH1 Gene

HGH1 (HGH1 Homolog) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HGH1 Gene

Genomics for HGH1 Gene

Regulatory Elements for HGH1 Gene

Enhancers for HGH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F144455 0.8 Ensembl ENCODE 11.6 +318.7 318678 1.6 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ZNF2 ZNF416 ZNF207 ZNF548 FOS ZNF623 ZNF251 ZNF250 VPS28 GPAA1 LRRC14 LOC105375803 ZNF517 ZNF34 PPP1R16A
GH08F144101 0.4 ENCODE 10.2 -33.9 -33858 4.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF623 ZNF250 ZNF251 ZNF517 LRRC14 TMED10P1 ENSG00000255164 WDR97 ZNF696 VPS28
GH08F143453 0.9 Ensembl ENCODE 10 -683.2 -683187 1.6 PKNOX1 ATF1 ARNT CREB3L1 ARID4B SIN3A DMAP1 GTF3C2 FOS NCOA1 TIGD5 VPS28 GPAA1 JRK ENSG00000255050 SLC52A2 ZNF623 MAFA-AS1 ADCK5 HGH1
GH08F144766 1.3 Ensembl ENCODE 10 +630.1 630126 2.3 ATF1 ARNT ARID4B SIN3A GLI4 ZNF48 GTF3C2 ZNF121 FOS TSHZ1 RPL8 GPAA1 VPS28 SLC52A2 ADCK5 HGH1 PARP10 ZNF34 LOC105375805 ZNF251
GH08F144796 1.1 ENCODE 10 +661.2 661215 5.0 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 KLF13 ZNF263 SP3 RPL8 C8orf82 VPS28 GPAA1 SLC52A2 ADCK5 HGH1 PARP10 LOC105375803 ZNF517
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HGH1 on UCSC Golden Path with GeneCards custom track

Promoters for HGH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001906758 131 1401

Genomic Location for HGH1 Gene

Chromosome:
8
Start:
144,137,769 bp from pter
End:
144,140,843 bp from pter
Size:
3,075 bases
Orientation:
Plus strand

Genomic View for HGH1 Gene

Genes around HGH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HGH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HGH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HGH1 Gene

Proteins for HGH1 Gene

  • Protein details for HGH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTY7-HGH1_HUMAN
    Recommended name:
    Protein HGH1 homolog
    Protein Accession:
    Q9BTY7
    Secondary Accessions:
    • P0CB43

    Protein attributes for HGH1 Gene

    Size:
    390 amino acids
    Molecular mass:
    42129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HGH1 Gene

Post-translational modifications for HGH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HGH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HGH1 Gene

Domains & Families for HGH1 Gene

Protein Domains for HGH1 Gene

Suggested Antigen Peptide Sequences for HGH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BTY7

UniProtKB/Swiss-Prot:

HGH1_HUMAN :
  • Belongs to the HGH1 family.
Family:
  • Belongs to the HGH1 family.
genes like me logo Genes that share domains with HGH1: view

No data available for Gene Families for HGH1 Gene

Function for HGH1 Gene

Gene Ontology (GO) - Molecular Function for HGH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HGH1: view

Phenotypes for HGH1 Gene

genes like me logo Genes that share phenotypes with HGH1: view

Animal Model Products

miRNA for HGH1 Gene

miRTarBase miRNAs that target HGH1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HGH1 Gene

Localization for HGH1 Gene

Gene Ontology (GO) - Cellular Components for HGH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with HGH1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for HGH1 Gene

Pathways & Interactions for HGH1 Gene

SuperPathways for HGH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HGH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HGH1: view

No data available for Pathways by source and SIGNOR curated interactions for HGH1 Gene

Transcripts for HGH1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HGH1 Gene

No ASD Table

Relevant External Links for HGH1 Gene

GeneLoc Exon Structure for
HGH1
ECgene alternative splicing isoforms for
HGH1

Expression for HGH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HGH1 Gene

Protein differential expression in normal tissues from HIPED for HGH1 Gene

This gene is overexpressed in Bone (45.7) and Pancreas (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HGH1 Gene



Protein tissue co-expression partners for HGH1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HGH1 Gene:

HGH1
genes like me logo Genes that share expression patterns with HGH1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HGH1 Gene

Orthologs for HGH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HGH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM203A 34
  • 99.11 (n)
-- 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC609695 34
  • 84.17 (n)
-- 35
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM203A 34
  • 84.13 (n)
-- 35
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam203a 34 35
  • 80.83 (n)
Hgh1 16
rat
(Rattus norvegicus)
Mammalia Fam203a 34
  • 79.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam203a 34
  • 60.79 (n)
Str.15925 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22740 34
zebrafish
(Danio rerio)
Actinopterygii fam203a 34 35
  • 57.65 (n)
CABZ01049059.1 35
  • 41 (a)
ManyToMany
Dr.16793 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3530 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001442 34
  • 51.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6073 34 35
  • 48.27 (n)
worm
(Caenorhabditis elegans)
Secernentea Y54H5A.2 35
  • 22 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL150W 34
  • 45.79 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15433g 34
  • 43.59 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HGH1 34 35
  • 40.71 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G14300 34
  • 45.86 (n)
rice
(Oryza sativa)
Liliopsida Os10g0406800 34
  • 41.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08324 34
  • 48.78 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC26F1.12c 34
  • 46.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for HGH1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HGH1 Gene

ENSEMBL:
Gene Tree for HGH1 (if available)
TreeFam:
Gene Tree for HGH1 (if available)

Paralogs for HGH1 Gene

No data available for Paralogs for HGH1 Gene

Variants for HGH1 Gene

Sequence variations from dbSNP and Humsavar for HGH1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs111864080 -- 144,137,661(+) TCCCC(C/G)CGCGC upstream-variant-2KB
rs11545441 -- 144,139,629(-) GCCTG(C/T)AGACA utr-variant-3-prime
rs140951165 -- 144,138,778(+) CTTGG(C/T)TGGGC nc-transcript-variant, reference, missense
rs144751258 -- 144,138,784(+) TGGGC(C/T)TGAGG nc-transcript-variant, reference, missense
rs146450411 -- 144,138,740(+) GGACC(A/G/T)GAGGT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HGH1 Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv906n27 CNV loss 19166990
esv2759651 CNV gain 17122850
esv29971 CNV loss 17803354
nsv1025071 CNV gain 25217958
nsv1030888 CNV gain 25217958
nsv1075598 CNV deletion 25765185
nsv1119194 CNV deletion 24896259
nsv1122205 CNV deletion 24896259
nsv1145205 CNV deletion 24896259
nsv428208 CNV gain 18775914
nsv466014 CNV loss 19166990
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612915 CNV loss 21841781
nsv824802 CNV gain 20364138
nsv824803 CNV gain 20364138
nsv8395 CNV gain+loss 18304495
nsv950016 CNV deletion 24416366

Variation tolerance for HGH1 Gene

Gene Damage Index Score: 0.13; 2.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HGH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HGH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HGH1 Gene

Disorders for HGH1 Gene

Relevant External Links for HGH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HGH1

No disorders were found for HGH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HGH1 Gene

Publications for HGH1 Gene

  1. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 64
  2. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 3 4 64
  3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 3 4 64
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 3 4 64
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64

Products for HGH1 Gene

Sources for HGH1 Gene

Content
Loading form....