Aliases for HGFAC Gene
External Ids for HGFAC Gene
Previous GeneCards Identifiers for HGFAC Gene
This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for HGFAC Gene
HGFAC (HGF Activator) is a Protein Coding gene. Diseases associated with HGFAC include Hepatocellular Fibrolamellar Carcinoma. Among its related pathways are Development HGF signaling pathway and Signaling by GPCR. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is F12.
UniProtKB/Swiss-Prot for HGFAC Gene
Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.