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HGFAC Gene

protein-coding   GIFtS: 63
GCID: GC04P003443

HGF Activator

  See HGFAC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HGF Activator1 2 3
HGFA2 3 5
Hepatocyte Growth Factor Activator2
EC 3.4.21.-3
EC 3.4.218

External Ids:    HGNC: 48941   Entrez Gene: 30832   Ensembl: ENSG000001097587   OMIM: 6045525   UniProtKB: Q047563   

Export aliases for HGFAC gene to outside databases

Previous GC identifers: GC04P003446 GC04P003347 GC04P003475 GC04P003480 GC04P003413


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HGFAC Gene:
The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive
single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as
serine protease that converts hepatocyte growth factor to the active form. (provided by RefSeq, Jul 2008)

GeneCards Summary for HGFAC Gene:
HGFAC (HGF activator) is a protein-coding gene. Diseases associated with HGFAC include idiopathic pulmonary fibrosis, and pancreatic cancer. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is PLG.

UniProtKB/Swiss-Prot: HGFA_HUMAN, Q04756
Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form

Gene Wiki entry for HGFAC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HGFAC gene promoter:
         STAT5B   USF1   AML1a   NRSF form 1   AP-4   LCR-F1   NRSF form 2   POU3F2   HSF2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHGFAC promoter sequence
   Search Chromatin IP Primers for HGFAC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HGFAC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16

HGFAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HGFAC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003443:  view genomic region     (about GC identifiers)

Start:
3,443,614 bp from pter      End:
3,451,213 bp from pter
Size:
7,600 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HGFA_HUMAN, Q04756 (See protein sequence)
Recommended Name: Hepatocyte growth factor activator precursor  
Size: 655 amino acids; 70682 Da
Subunit: Heterodimer of a short chain and a long chain linked by a disulfide bond
Caution: It is uncertain whether Met-1 is the initiator
Selected PDB 3D structures from and Proteopedia for HGFAC (see all 7):
1YBW (3D)        1YC0 (3D)        2R0K (3D)        2R0L (3D)        2WUB (3D)        2WUC (3D)    
Secondary accessions: Q14726 Q2M1W7 Q53X47

Explore the universe of human proteins at neXtProt for HGFAC: NX_Q04756

Explore proteomics data for HGFAC at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn48, Asn290, Asn468, Asn546
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HGFAC (Q04756) (see all 5)
     PWLAAIY  GDSGGPL  CQGDSGGP  WVVSAAHC 


    See HGFAC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001519.1  
    ENSEMBL proteins: 
     ENSP00000372224   ENSP00000421801  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 12):
     IPR000083 Fibronectin_type1
     IPR001314 Peptidase_S1A
     IPR014394 Coagulation_fac_XIIa/HGFA
     IPR000742 EG-like_dom
     IPR018056 Kringle_CS

    Graphical View of Domain Structure for InterPro Entry Q04756

    ProtoNet protein and cluster: Q04756

    Selected Blocks protein domains (see all 6):
    IPB000001 Kringle
    IPB000083 Fibronectin
    IPB000562 Type II fibronectin collagen-binding domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: HGFA_HUMAN, Q04756
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 fibronectin type-I domain
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with HGFAC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HGFA_HUMAN, Q04756
    Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form

         Genatlas biochemistry entry for HGFAC:
    hepatocyte growth factor activator,precursor,serine protease involved in the endoproteolytic processing of HGF

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008236serine-type peptidase activity TAS8226803
         
    Find genes that share ontologies with HGFAC           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for HGFAC:
     Decreased Salmonella enterica   Decreased circadian period len  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hgfac):
     digestive/alimentary  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with HGFAC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HGFAC: Hgfactm1Hk Hgfactm1Lex

       genOway: Develop your customized and physiologically relevant rodent model for HGFAC

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HGFA_HUMAN, Q04756: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a
    heterodimeric form
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum2
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005791rough endoplasmic reticulum IEA--

    Find genes that share ontologies with HGFAC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HGFAC About    
    See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Development HGF signaling pathway0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for HGFAC
        Development HGF signaling pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HGFAC
    Interactions:

        GeneGlobe Interaction Network for HGFAC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for HGFAC (Q047563 ENSP000003722244) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    HGFP142103, ENSP000002223904I2D: score=1 STRING: ENSP00000222390
    KLKB1P039523, ENSP000002646904I2D: score=1 STRING: ENSP00000264690
    SPINT1O432783, ENSP000003420984I2D: score=3 STRING: ENSP00000342098
    SPINT2O432913, ENSP000003012444I2D: score=1 STRING: ENSP00000301244
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS8226803

    Find genes that share ontologies with HGFAC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HGFAC (HGFA)

    6 Novoseek inferred chemical compound relationships for HGFAC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 77.6 95 18221492 (2), 20402766 (2), 12784998 (2), 15172968 (2) (see all 53)
    dextran sulfate 45 1 7744037 (1)
    5-aza-2'deoxycytidine 41.8 1 15911243 (1)
    tyrosine 18.7 2 15859160 (1)
    fibrinogen 6.44 1 12527708 (1)
    heparin 0 7 17456194 (2), 8631970 (2)



    Find genes that share compounds with HGFAC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HGFAC gene: 
    NM_001528.2  

    Unigene Cluster for HGFAC:

    HGF activator
    Hs.104  [show with all ESTs]
    Unigene Representative Sequence: BC112192
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382774(uc003ghc.3 uc010icw.3) ENST00000511533 ENST00000509689
    ENST00000506132
    miRNA
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    Additional mRNA sequence: 

    AK314099.1 BC112190.1 BC112192.1 D14012.1 

    2 DOTS entries:

    DT.442148  DT.99988180 

    15 AceView cDNA sequences:

    CR626692 BI831151 NM_001528 AV647212 BX109192 D14012 BX427644 AV646680 
    R89811 T72625 H61206 AI243638 T72695 H62111 AA897612 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HGFAC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGTGCCG
    HGFAC Expression
    About this image


    HGFAC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
    HGFAC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HGFAC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104

    UniProtKB/Swiss-Prot: HGFA_HUMAN, Q04756
    Tissue specificity: Liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HGFAC gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hgfac1 , 5 hepatocyte growth factor activator1, 5 81.59(n)1
    82.61(a)1
      5 (17.99 cM)5
    544261  NM_019447.21  NP_062320.21 
     350415535 
    chicken
    (Gallus gallus)
    Aves HGFAC1 HGF activator 61.09(n)
    62.32(a)
      422876  XM_420819.4  XP_420819.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119752 Transcribed sequence with weak similarity to protein more 75.34(n)    CF376345.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01065401.16
    Uncharacterized protein
    48(a)
    1 ↔ 1
    8(2143249-2145996) ENSDARG00000091759


    ENSEMBL Gene Tree for HGFAC (if available)
    TreeFam Gene Tree for HGFAC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HGFAC gene
    PLG2  PLAT2  HABP22  LPA2  PLAU2  MST12  F122  HGF2  
    Selected SIMAP similar genes for HGFAC using alignment to 2 protein entries:     HGFA_HUMAN (see all proteins) (see all similar genes):
    DKFZp586F0824    PRSS8    F12    PRSS1    CELA3A    CELA2A
    PROC1    PROC    TMPRSS5    CTRL    ELA2A    PRSS22
    CTRC    GZMK    KLK4    KLK9    F9    CELA2B

    Find genes that share paralogs with HGFAC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HGFAC (see all 409)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753302671,2
    F--3419840(+) TTCTCG/AGGGAC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs7628621,2
    C,F--3442146(+) TCAGAG/CCATCC 1 -- us2k112Minor allele frequency- C:0.34MN NA WA CSA EA 557
    rs731934001,2
    C,F--3442259(+) GGGTCG/AGAATG 1 -- us2k13Minor allele frequency- A:0.29NA 124
    rs1920807051,2
    --3442429(+) CACCAC/TGCCTC 1 -- us2k10--------
    rs1426673331,2
    C--3442540(+) CCAACC/TCCCCA 1 -- us2k10--------
    rs1167726791,2
    C,F--3442550(+) ATTCAC/TCGTGC 1 -- us2k12Minor allele frequency- T:0.14WA NA 238
    rs767582031,2
    C,F--3442572(+) ACCACG/ACCTCC 1 -- us2k11Minor allele frequency- A:0.11WA 118
    rs1848829131,2
    --3442590(+) CTGTGC/TCCCCT 1 -- us2k10--------
    rs731934021,2
    C--3442630(+) GTGGGC/TGTCCA 1 -- us2k10--------
    rs1155130371,2
    C,F--3442638(+) CCATTC/GTCTCT 1 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for HGFAC (3443614 - 3451213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HGFAC (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662185CNV Deletion23128226
    dgv5433n71CNV Loss21882294
    nsv818208CNV Loss17921354
    nsv829840CNV Loss17160897
    nsv878462CNV Loss21882294
    nsv4202CNV Loss18451855
    dgv5431n71CNV Loss21882294
    nsv878456CNV Loss21882294
    nsv878464CNV Loss21882294
    dgv5432n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604552    OMIM disorders: --

    3 diseases for HGFAC:    
    About MalaCards
    idiopathic pulmonary fibrosis    pancreatic cancer    hepatocellular carcinoma


    Find genes that share disorders with HGFAC           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HGFAC gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 37 6 16106403 (2), 11433397 (1), 7556648 (1)
    colorectal carcinoma 35.6 10 11085539 (3), 11436357 (2), 9683286 (1), 10695988 (1)
    pancreatic cancer 23.2 2 18422749 (2)
    adenocarcinoma 14.8 2 15471558 (1)
    prostate cancer 14 5 16005141 (4)
    gastric carcinoma 10.5 2 9346890 (1), 9045658 (1)
    cancer 10.4 8 11562767 (4), 11193201 (1), 19379214 (1)
    tumors 9.96 9 18221492 (1), 12784998 (1), 16189274 (1), 14713848 (1) (see all 7)
    glioma 7.71 2 7556648 (2)
    benign prostatic hyperplasia 7 3 16005141 (2)

    Genetic Association Database (GAD): HGFAC
    Human Genome Epidemiology (HuGE) Navigator: HGFAC (1 document)

    Export disorders for HGFAC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HGFAC gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with HGFAC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. (PubMed id 7683665)1, 2, 3, 9 Miyazawa K....Kitamura N. (J. Biol. Chem. 1993)
    2. Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. (PubMed id 15713485)1, 2, 9 Shia S.... Eigenbrot C. (J. Mol. Biol. 2005)
    3. Activation of the zymogen of hepatocyte growth factor activator by thrombin. (PubMed id 8226803)1, 3, 9 Shimomura T....Kitamura N. (J. Biol. Chem. 1993)
    4. Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene -- phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue- type plasminogen activator. (PubMed id 9874200)1, 2, 9 Miyazawa K.... Kitamura N. (Eur. J. Biochem. 1998)
    5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. (PubMed id 18422749)1, 9 Kitajima Y....Miyazaki K. (Cancer Sci. 2008)
    9. Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein. (PubMed id 19456860)1, 9 Kawaguchi M....Kataoka H. (FEBS J. 2009)
    10. Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma. (PubMed id 18691255)1, 9 Wader K.F....Waage A. (Eur. J. Haematol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3083 HGNC: 4894 AceView: HGFAC Ensembl:ENSG00000109758 euGenes: HUgn3083
    ECgene: HGFAC H-InvDB: HGFAC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HGFAC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HGFAC gene:
    Search GeneIP for patents involving HGFAC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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