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Aliases for HGFAC Gene

Aliases for HGFAC Gene

  • HGF Activator 2 3 4
  • HGFA 3 4
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for HGFAC Gene

Previous GeneCards Identifiers for HGFAC Gene

  • GC04P003446
  • GC04P003347
  • GC04P003475
  • GC04P003480
  • GC04P003413

Summaries for HGFAC Gene

Entrez Gene Summary for HGFAC Gene

  • This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for HGFAC Gene

HGFAC (HGF Activator) is a Protein Coding gene. Diseases associated with HGFAC include hepatocellular fibrolamellar carcinoma. Among its related pathways are Development HGF signaling pathway. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for HGFAC Gene

  • Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form

Gene Wiki entry for HGFAC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HGFAC Gene

Genomics for HGFAC Gene

Regulatory Elements for HGFAC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HGFAC Gene

Chromosome:
4
Start:
3,441,887 bp from pter
End:
3,449,495 bp from pter
Size:
7,609 bases
Orientation:
Plus strand

Genomic View for HGFAC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HGFAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HGFAC Gene

Proteins for HGFAC Gene

  • Protein details for HGFAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04756-HGFA_HUMAN
    Recommended name:
    Hepatocyte growth factor activator
    Protein Accession:
    Q04756
    Secondary Accessions:
    • Q14726
    • Q2M1W7
    • Q53X47

    Protein attributes for HGFAC Gene

    Size:
    655 amino acids
    Molecular mass:
    70682 Da
    Quaternary structure:
    • Heterodimer of a short chain and a long chain linked by a disulfide bond.

    Three dimensional structures from OCA and Proteopedia for HGFAC Gene

neXtProt entry for HGFAC Gene

Proteomics data for HGFAC Gene at MOPED

Selected DME Specific Peptides for HGFAC Gene

Post-translational modifications for HGFAC Gene

  • Glycosylation at Asn 48, Asn 290, Asn 468, and Asn 546
  • Modification sites at PhosphoSitePlus

Other Protein References for HGFAC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HGFAC (HGF Activator)

Domains & Families for HGFAC Gene

Suggested Antigen Peptide Sequences for HGFAC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04756

UniProtKB/Swiss-Prot:

HGFA_HUMAN :
  • Contains 2 EGF-like domains.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 fibronectin type-I domain.
  • Contains 1 fibronectin type-II domain.
  • Contains 1 kringle domain.
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with HGFAC: view

No data available for Gene Families for HGFAC Gene

Function for HGFAC Gene

Molecular function for HGFAC Gene

GENATLAS Biochemistry:
hepatocyte growth factor activator,precursor,serine protease involved in the endoproteolytic processing of HGF
UniProtKB/Swiss-Prot Function:
Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form

Enzyme Numbers (IUBMB) for HGFAC Gene

Gene Ontology (GO) - Molecular Function for HGFAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008236 serine-type peptidase activity TAS 8226803
genes like me logo Genes that share ontologies with HGFAC: view
genes like me logo Genes that share phenotypes with HGFAC: view

Animal Models for HGFAC Gene

MGI Knock Outs for HGFAC:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HGFAC

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for HGFAC Gene

Localization for HGFAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HGFAC Gene

Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HGFAC Gene COMPARTMENTS Subcellular localization image for HGFAC gene
Compartment Confidence
extracellular 5
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HGFAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm --
GO:0005791 rough endoplasmic reticulum --
genes like me logo Genes that share ontologies with HGFAC: view

Pathways & Interactions for HGFAC Gene

genes like me logo Genes that share pathways with HGFAC: view

Pathways by source for HGFAC Gene

1 GeneGo (Thomson Reuters) pathway for HGFAC Gene

Gene Ontology (GO) - Biological Process for HGFAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with HGFAC: view

No data available for SIGNOR curated interactions for HGFAC Gene

Drugs & Compounds for HGFAC Gene

(3) Drugs for HGFAC Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 672,226
serine Nutra 420
tyrosine Nutra 547

(3) Additional Compounds for HGFAC Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Aza-2deoxycytidine
dextran sulfate
FIBRINOGEN
genes like me logo Genes that share compounds with HGFAC: view

Transcripts for HGFAC Gene

mRNA/cDNA for HGFAC Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HGFAC Gene

HGF activator:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HGFAC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HGFAC Gene

No ASD Table

Relevant External Links for HGFAC Gene

GeneLoc Exon Structure for
HGFAC
ECgene alternative splicing isoforms for
HGFAC

Expression for HGFAC Gene

mRNA expression in normal human tissues for HGFAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HGFAC Gene

This gene is overexpressed in Liver (x45.1).

Protein differential expression in normal tissues from HIPED for HGFAC Gene

This gene is overexpressed in Serum (25.7), Plasma (20.0), and Synovial fluid (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HGFAC Gene



SOURCE GeneReport for Unigene cluster for HGFAC Gene Hs.104

mRNA Expression by UniProt/SwissProt for HGFAC Gene

Q04756-HGFA_HUMAN
Tissue specificity: Liver
genes like me logo Genes that share expression patterns with HGFAC: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for HGFAC Gene

Orthologs for HGFAC Gene

This gene was present in the common ancestor of animals.

Orthologs for HGFAC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HGFAC 36
  • 98 (a)
OneToOne
HGFAC 35
  • 99.13 (n)
  • 98.63 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HGFAC 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hgfac 36
  • 81 (a)
OneToOne
Hgfac 16
Hgfac 35
  • 81.59 (n)
  • 82.61 (a)
oppossum
(Monodelphis domestica)
Mammalia HGFAC 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HGFAC 36
  • 84 (a)
OneToOne
HGFAC 35
  • 84.79 (n)
  • 84.84 (a)
cow
(Bos Taurus)
Mammalia HGFAC 36
  • 92 (a)
OneToOne
HGFAC 35
  • 85.08 (n)
  • 82.77 (a)
rat
(Rattus norvegicus)
Mammalia Hgfac 35
  • 81.11 (n)
  • 81.86 (a)
chicken
(Gallus gallus)
Aves HGFAC 36
  • 59 (a)
OneToOne
HGFAC 35
  • 61.09 (n)
  • 62.32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11975 35
hgfac 35
  • 57.92 (n)
  • 55.45 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01065401.1 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tequila 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea C07G1.1 37
  • 34 (a)
Species with no ortholog for HGFAC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HGFAC Gene

ENSEMBL:
Gene Tree for HGFAC (if available)
TreeFam:
Gene Tree for HGFAC (if available)

Paralogs for HGFAC Gene

Paralogs for HGFAC Gene

genes like me logo Genes that share paralogs with HGFAC: view

Variants for HGFAC Gene

Sequence variations from dbSNP and Humsavar for HGFAC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_024294 -
VAR_024295 -
VAR_033651 -
VAR_033652 -
VAR_051851 -

Structural Variations from Database of Genomic Variants (DGV) for HGFAC Gene

Variant ID Type Subtype PubMed ID
nsv878456 CNV Loss 21882294
nsv878462 CNV Loss 21882294
nsv878463 CNV Loss 21882294
nsv428435 CNV Gain 18775914
essv879 CNV CNV 17122850
dgv1566e1 CNV Complex 17122850
dgv637n27 CNV Loss 19166990
nsv878464 CNV Loss 21882294
dgv5429n71 CNV Loss 21882294
dgv5430n71 CNV Loss 21882294
dgv5431n71 CNV Loss 21882294
nsv878471 CNV Loss 21882294
dgv5432n71 CNV Loss 21882294
nsv461169 CNV Loss 19166990
nsv470004 CNV Loss 18288195
nsv818208 CNV Loss 17921354
nsv516505 CNV Loss 19592680
nsv10424 CNV Gain 18304495
nsv4202 CNV Loss 18451855
nsv829840 CNV Loss 17160897
esv2662185 CNV Deletion 23128226
dgv5433n71 CNV Loss 21882294

Variation tolerance for HGFAC Gene

Residual Variation Intolerance Score: 96.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.36; 88.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HGFAC Gene

HapMap Linkage Disequilibrium report
HGFAC
Human Gene Mutation Database (HGMD)
HGFAC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HGFAC Gene

Disorders for HGFAC Gene

MalaCards: The human disease database

(1) MalaCards diseases for HGFAC Gene - From: DISEASES

Disorder Aliases PubMed IDs
hepatocellular fibrolamellar carcinoma
  • hepatocellular carcinoma, fibrolamellar
- elite association
Search HGFAC in MalaCards View complete list of genes associated with diseases

Relevant External Links for HGFAC

Genetic Association Database (GAD)
HGFAC
Human Genome Epidemiology (HuGE) Navigator
HGFAC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HGFAC
genes like me logo Genes that share disorders with HGFAC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HGFAC Gene

Publications for HGFAC Gene

  1. Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. (PMID: 7683665) Miyazawa K. … Kitamura N. (J. Biol. Chem. 1993) 2 23 67
  2. Activation of the zymogen of hepatocyte growth factor activator by thrombin. (PMID: 8226803) Shimomura T. … Kitamura N. (J. Biol. Chem. 1993) 2 23 67
  3. Hepatocyte growth factor activation inhibitors - therapeutic potential in cancer. (PMID: 20015004) Parr C. … Jiang W.G. (Anticancer Agents Med Chem 2010) 23 67
  4. Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor. (PMID: 20402764) Suzuki K. (FEBS J. 2010) 23 67
  5. Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1). (PMID: 20402765) Eigenbrot C. … Kirchhofer D. (FEBS J. 2010) 23 67

Products for HGFAC Gene

Sources for HGFAC Gene

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