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Aliases for HGFAC Gene

Aliases for HGFAC Gene

  • HGF Activator 2 3 4
  • HGFA 3 4 6
  • Hepatocyte Growth Factor Activator 3
  • EC 3.4.21.- 4
  • EC 3.4.21 64

External Ids for HGFAC Gene

Summaries for HGFAC Gene

Entrez Gene Summary for HGFAC Gene

  • This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for HGFAC Gene

HGFAC (HGF Activator) is a Protein Coding gene. Diseases associated with HGFAC include pancreatic cancer and hepatocellular carcinoma. Among its related pathways are Development HGF signaling pathway. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for HGFAC Gene

  • Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form

Gene Wiki entry for HGFAC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HGFAC Gene

Genomics for HGFAC Gene

Genomic Location for HGFAC Gene

3,441,887 bp from pter
3,449,495 bp from pter
7,609 bases
Plus strand

Genomic View for HGFAC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HGFAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HGFAC Gene

Regulatory Elements for HGFAC Gene

Proteins for HGFAC Gene

  • Protein details for HGFAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatocyte growth factor activator
    Protein Accession:
    Secondary Accessions:
    • Q14726
    • Q2M1W7
    • Q53X47

    Protein attributes for HGFAC Gene

    655 amino acids
    Molecular mass:
    70682 Da
    Quaternary structure:
    • Heterodimer of a short chain and a long chain linked by a disulfide bond.

    Three dimensional structures from OCA and Proteopedia for HGFAC Gene

neXtProt entry for HGFAC Gene

Proteomics data for HGFAC Gene at MOPED

Selected DME Specific Peptides for HGFAC Gene

Post-translational modifications for HGFAC Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn48, Asn290, Asn468, and Asn546

Other Protein References for HGFAC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for HGFAC Gene


  • Contains 2 EGF-like domains.:
    • Q04756
  • Contains 1 fibronectin type-I domain.:
    • Q04756
  • Contains 1 fibronectin type-II domain.:
    • Q04756
  • Contains 1 kringle domain.:
    • Q04756
  • Contains 1 peptidase S1 domain.:
    • Q04756
  • Belongs to the peptidase S1 family.:
    • Q04756
genes like me logo Genes that share domains with HGFAC: view

No data available for Gene Families for HGFAC Gene

Function for HGFAC Gene

Molecular function for HGFAC Gene

GENATLAS Biochemistry: hepatocyte growth factor activator,precursor,serine protease involved in the endoproteolytic processing of HGF
UniProtKB/Swiss-Prot Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form

Enzyme Numbers (IUBMB) for HGFAC Gene

Gene Ontology (GO) - Molecular Function for HGFAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008236 serine-type peptidase activity TAS 8226803
genes like me logo Genes that share ontologies with HGFAC: view
genes like me logo Genes that share phenotypes with HGFAC: view

Animal Models for HGFAC Gene

MGI Knock Outs for HGFAC:

miRNA for HGFAC Gene

miRTarBase miRNAs that target HGFAC

No data available for Transcription Factor Targeting and HOMER Transcription for HGFAC Gene

Localization for HGFAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HGFAC Gene

Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.

Subcellular locations from

Jensen Localization Image for HGFAC Gene COMPARTMENTS Subcellular localization image for HGFAC gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 1

Gene Ontology (GO) - Cellular Components for HGFAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm --
GO:0005791 rough endoplasmic reticulum --
genes like me logo Genes that share ontologies with HGFAC: view

Pathways for HGFAC Gene

genes like me logo Genes that share pathways with HGFAC: view

Pathways by source for HGFAC Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for HGFAC Gene

Gene Ontology (GO) - Biological Process for HGFAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with HGFAC: view

Compounds for HGFAC Gene

(6) Novoseek inferred chemical compound relationships for HGFAC Gene

Compound -log(P) Hits PubMed IDs
serine 77.6 61
dextran sulfate 45 1
5-aza-2deoxycytidine 41.8 1
tyrosine 18.7 1
fibrinogen 6.44 1
genes like me logo Genes that share compounds with HGFAC: view

Transcripts for HGFAC Gene

mRNA/cDNA for HGFAC Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HGFAC Gene

HGF activator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HGFAC Gene

No ASD Table

Relevant External Links for HGFAC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HGFAC Gene

mRNA expression in normal human tissues for HGFAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HGFAC Gene

This gene is overexpressed in Liver (45.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HGFAC Gene

SOURCE GeneReport for Unigene cluster for HGFAC Gene Hs.104

mRNA Expression by UniProt/SwissProt for HGFAC Gene

Tissue specificity: Liver
genes like me logo Genes that share expressions with HGFAC: view

Orthologs for HGFAC Gene

This gene was present in the common ancestor of animals.

Orthologs for HGFAC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HGFAC 36
  • 99.13 (n)
  • 98.63 (a)
  • 98 (a)
(Bos Taurus)
Mammalia HGFAC 36
  • 85.08 (n)
  • 82.77 (a)
  • 92 (a)
(Canis familiaris)
Mammalia HGFAC 36
  • 84.79 (n)
  • 84.84 (a)
  • 84 (a)
(Mus musculus)
Mammalia Hgfac 36
  • 81.59 (n)
  • 82.61 (a)
Hgfac 16
Hgfac 37
  • 81 (a)
(Monodelphis domestica)
Mammalia HGFAC 37
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia HGFAC 37
  • 61 (a)
(Rattus norvegicus)
Mammalia Hgfac 36
  • 81.11 (n)
  • 81.86 (a)
(Gallus gallus)
Aves HGFAC 36
  • 61.09 (n)
  • 62.32 (a)
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hgfac 36
  • 57.92 (n)
  • 55.45 (a)
Str.11975 36
(Danio rerio)
Actinopterygii CABZ01065401.1 37
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tequila 38
  • 36 (a)
(Caenorhabditis elegans)
Secernentea C07G1.1 38
  • 34 (a)
Species with no ortholog for HGFAC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HGFAC Gene

Gene Tree for HGFAC (if available)
Gene Tree for HGFAC (if available)

Paralogs for HGFAC Gene

Paralogs for HGFAC Gene

genes like me logo Genes that share paralogs with HGFAC: view

Variants for HGFAC Gene

Sequence variations from dbSNP and Humsavar for HGFAC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs743713 -- 3,441,571(-) CTCTG(C/T)GCCCA upstream-variant-2KB
rs762862 -- 3,440,419(+) TCAGA(C/G)CATCC upstream-variant-2KB
rs1794408 -- 3,441,344(-) CCAGG(C/G)CCCCC upstream-variant-2KB
rs1987546 - 3,444,405(+) TGCTT(C/G)GGGGG reference, missense
rs2073504 -- 3,442,866(-) GGGGG(C/T)GGGAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for HGFAC Gene

Variant ID Type Subtype PubMed ID
nsv878456 CNV Loss 21882294
nsv878462 CNV Loss 21882294
nsv878463 CNV Loss 21882294
nsv428435 CNV Gain 18775914
essv879 CNV CNV 17122850
dgv1566e1 CNV Complex 17122850
dgv637n27 CNV Loss 19166990
nsv878464 CNV Loss 21882294
dgv5429n71 CNV Loss 21882294
dgv5430n71 CNV Loss 21882294
dgv5431n71 CNV Loss 21882294
nsv878471 CNV Loss 21882294
dgv5432n71 CNV Loss 21882294
nsv461169 CNV Loss 19166990
nsv470004 CNV Loss 18288195
nsv818208 CNV Loss 17921354
nsv516505 CNV Loss 19592680
nsv10424 CNV Gain 18304495
nsv4202 CNV Loss 18451855
nsv829840 CNV Loss 17160897
esv2662185 CNV Deletion 23128226
dgv5433n71 CNV Loss 21882294

Relevant External Links for HGFAC Gene

HapMap Linkage Disequilibrium report

Disorders for HGFAC Gene

(19) Novoseek inferred disease relationships for HGFAC Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 37 4
colorectal carcinoma 35.6 7
pancreatic cancer 23.2 2
adenocarcinoma 14.8 1
prostate cancer 14 4

Relevant External Links for HGFAC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HGFAC: view

No data available for UniProtKB/Swiss-Prot for HGFAC Gene

Publications for HGFAC Gene

  1. Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. (PMID: 7683665) Miyazawa K. … Kitamura N. (J. Biol. Chem. 1993) 2 3 4 23
  2. Activation of the zymogen of hepatocyte growth factor activator by thrombin. (PMID: 8226803) Shimomura T. … Kitamura N. (J. Biol. Chem. 1993) 2 3 23
  3. Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene -- phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue- type plasminogen activator. (PMID: 9874200) Miyazawa K. … Kitamura N. (Eur. J. Biochem. 1998) 3 4 23
  4. Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. (PMID: 15713485) Shia S. … Eigenbrot C. (J. Mol. Biol. 2005) 3 4 23
  5. Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. (PMID: 9346890) Kawaguchi T. … Kitamura N. (J. Biol. Chem. 1997) 3 23

Products for HGFAC Gene

Sources for HGFAC Gene

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