Aliases for HGFAC Gene
External Ids for HGFAC Gene
Previous GeneCards Identifiers for HGFAC Gene
This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for HGFAC Gene
HGFAC (HGF Activator) is a Protein Coding gene. Diseases associated with HGFAC include pancreatic cancer and hepatocellular carcinoma. Among its related pathways are Development HGF signaling pathway. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is PLAT.
UniProtKB/Swiss-Prot for HGFAC Gene
Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form