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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HGFAC Gene

protein-coding   GIFtS: 59
GCID: GC04P003443

HGF activator
 Explore 27 diseases affiliated with
HGFAC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HGFAC    

Aliases
for HGFAC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HGF Activator1 2 3
HGFA1 2 3 5
HGFAP1
Hepatocyte Growth Factor Activator2
EC 3.4.21.-3
EC 3.4.218

External Ids:    HGNC: 48941   Entrez Gene: 30832   Ensembl: ENSG000001097587   OMIM: 6045525   UniProtKB: Q047563   

Export aliases for HGFAC gene to outside databases

Previous GC identifers: GC04P003446 GC04P003347 GC04P003475 GC04P003480 GC04P003413


Summaries
for HGFAC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HGFAC:
The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain
precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease
that converts hepatocyte growth factor to the active form. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HGFA_HUMAN, Q04756
Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form

Gene Wiki entry for HGFAC


Genomic Views
for HGFAC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HGFAC gene promoter:
         STAT5B   USF1   AML1a   NRSF form 1   AP-4   LCR-F1   NRSF form 2   POU3F2   HSF2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HGFAC promoter sequence
   Search SABiosciences Chromatin IP Primers for HGFAC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HGFAC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16

HGFAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HGFAC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003443:  view genomic region     (about GC identifiers)

Start:
 3,443,614 bp from pter      End:
 3,451,213 bp from pter
Size:
 7,600 bases      Orientation:
 plus strand

Proteins
for HGFAC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HGFA_HUMAN, Q04756 (See protein sequence)
Recommended Name: Hepatocyte growth factor activator precursor  
Size: 655 amino acids; 70682 Da
Subunit: Heterodimer of a short chain and a long chain linked by a disulfide bond
Subcellular location: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a
heterodimeric form
Caution: It is uncertain whether Met-1 is the initiator
6/7 PDB 3D structures from and Proteopedia for HGFAC (see all 7):
1YBW (3D)        1YC0 (3D)        2R0K (3D)        2R0L (3D)        2WUB (3D)        2WUC (3D)    
Secondary accessions: Q14726 Q2M1W7 Q53X47

Explore the universe of human proteins at neXtProt for HGFAC: NX_Q04756

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q04756

    • 4/5 DME Specific Peptides for HGFAC (Q04756) (see all 5)
     PWLAAIY  GDSGGPL  CQGDSGGP  WVVSAAHC 

    HGFAC Protein expression data from MOPED and PaxDb:    About this image 
    HGFAC Protein Expression
    REFSEQ proteins: NP_001519.1  
    ENSEMBL proteins: 
     ENSP00000372224   ENSP00000421801  

    Human Recombinant Protein Products for HGFAC: 
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    Sino Biological Recombinant Protein for HGFAC
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    Uscn Proteins for HGFAC

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005791rough endoplasmic reticulum IEA--

    HGFAC for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HGFAC

    Protein Domains /
    Families
    for HGFAC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGFAC for domains           About GeneDecksing

    5/12 InterPro domains/families (see all 12):
     IPR000083 Fibronectin_type1
     IPR001314 Peptidase_S1A
     IPR014394 Coagulation_fac_XIIa/HGFA
     IPR000742 EG-like_dom
     IPR018056 Kringle_CS

    Graphical View of Domain Structure for InterPro Entry Q04756

    ProtoNet protein and cluster: Q04756

    5/6 Blocks protein families (see all 6):
    IPB000001 Kringle
    IPB000083 Fibronectin
    IPB000562 Type II fibronectin collagen-binding domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: HGFA_HUMAN, Q04756
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 fibronectin type-I domain
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 peptidase S1 domain


    Function
    for HGFAC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HGFA_HUMAN, Q04756
    Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form

         Genatlas biochemistry entry for HGFAC:
    hepatocyte growth factor activator,precursor,serine protease involved in the endoproteolytic processing of HGF

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS8226803
         
    HGFAC for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for HGFAC:
     Decreased Salmonella enterica   Decreased circadian period len  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hgfac):
     digestive/alimentary  homeostasis/metabolism  mortality/aging 

    HGFAC for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for HGFAC: Hgfactm1Hk Hgfactm1Lex
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HGFAC 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGFAC


    Pathways & Interactions
    for HGFAC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development HGF signaling pathway
    		Development HGF signaling pathway1.00
    		Development_HGF signaling pathway0.78

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for HGFAC
        Development HGF signaling pathway


    1 GeneGo (Thomson Reuters) Pathway for HGFAC
        Development HGF signaling pathway



    HGFAC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HGFAC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for HGFAC (Q047563 ENSP000003722244) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    HGFP142103, ENSP000002223904I2D: score=1 STRING: ENSP00000222390
    KLKB1P039523, ENSP000002646904I2D: score=1 STRING: ENSP00000264690
    SPINT1O432783, ENSP000003420984I2D: score=3 STRING: ENSP00000342098
    SPINT2O432913, ENSP000003012444I2D: score=1 STRING: ENSP00000301244
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    HGFAC for ontologies           About GeneDecksing



    Drugs & Compounds
    for HGFAC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HGFAC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HGFAC
    6 Novoseek chemical compound relationships for HGFAC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 77.6 95 18221492 (2), 20402766 (2), 12784998 (2), 15172968 (2) (see all 53)
    dextran sulfate 45 1 7744037 (1)
    5-aza-2'deoxycytidine 41.8 1 15911243 (1)
    tyrosine 18.7 2 15859160 (1)
    fibrinogen 6.44 1 12527708 (1)
    heparin 0 7 17456194 (2), 8631970 (2)

    Search CenterWatch for drugs/clinical trials and news about HGFAC / HGFA 

    Transcripts
    for HGFAC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HGFAC gene: 
    NM_001528.2  

    Unigene Cluster for HGFAC:

    HGF activator
    Hs.104  [show with all ESTs]
    Unigene Representative Sequence: BC112192
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382774(uc003ghc.3 uc010icw.3) ENST00000511533 ENST00000509689
    ENST00000506132

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HGFAC (see all 7)
    OriGene shRNA RFP: HGFAC
    OriGene siRNA: HGFAC
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HGFAC (NM_001528)
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    Primer
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    Additional cDNA sequence: 

    AK314099.1 BC112190.1 BC112192.1 D14012.1 

    2 DOTS entries:

    DT.442148  DT.99988180 

    15 AceView cDNA sequences:

    NM_001528 AV647212 BI831151 CR626692 D14012 BX109192 BX427644 AV646680 
    H61206 R89811 T72625 AI243638 T72695 H62111 AA897612 

    GeneLoc Exon Structure


    Expression
    for HGFAC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HGFAC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCTGTGCCG
    HGFAC Expression
    About this image

    HGFAC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See HGFAC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HGFAC

    SOURCE GeneReport for Unigene cluster: Hs.104

    UniProtKB/Swiss-Prot: HGFA_HUMAN, Q04756
    Tissue specificity: Liver

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    In Situ
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    Orthologs
    for HGFAC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HGFAC gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HGFAC1 HGF activator 61.92(n)
    63.24(a)    		   422876  XM_420819.3  XP_420819.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HGFAC6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL343236.1(2267235-2280349)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.119752 Transcribed sequence with weak similarity to protein more 75.34(n)    CF376345.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01065401.16
    		 --
    		 44(a)
    		 1 ↔ 1
    		 8(2143249-2145996)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 5(a)
    		 possible ortholog
    		 GroupUn.841(30640-42833)


    ENSEMBL Gene Tree for HGFAC (if available)
    TreeFam Gene Tree for HGFAC (if available) 

    Paralogs
    for HGFAC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HGFAC gene
    KREMEN12  KREMEN22  PLAT2  PLG2  LPA2  PLAU2  HABP22  MST12  
    F122  MST1L2  HGF2  
    18/69 SIMAP similar genes for HGFAC using alignment to 2 protein entries:     HGFA_HUMAN (see all proteins) (see all similar genes):
    DKFZp586F0824    PRSS8    F12    PRSS1    CELA3A    CELA2A
    PROC1    PROC    TMPRSS5    CTRL    ELA2A    PRSS22
    CTRC    GZMK    KLK4    KLK9    F9    CELA2B

    HGFAC for paralogs           About GeneDecksing



    Genomic Variants
    for HGFAC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/285 NCBI SNPs in HGFAC are shown (see all 285)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1827792341,2
    		--3441740(+) CTGAGA/GAGGAG 3 -- us2k1 ds50010--------
    rs1874895621,2
    		--3441843(+) CTCGCC/TGTCAC 3 -- us2k1 ds50010--------
    rs1909851471,2
    		--3441929(+) CTGGAC/TGGCAG 3 -- us2k1 ds50010--------
    rs1142549141,2
    		F--3441988(+) GGAGGG/ATCTGA 3 -- us2k1 ds50011Minor allele frequency- A:0.03WA 118
    rs7628611,2
    		C,F,O,A,H--3442011(+) AACCAG/CGTGTG 3 -- ds5001 us2k114Minor allele frequency- C:0.46NA EA NS WA CSA 2342
    rs1830747041,2
    		--3442029(+) GGGAGG/TCCGGG 3 -- ds5001 us2k10--------
    rs1159117221,2
    		F--3442058(+) AGTCGG/CAAGAG 3 -- us2k1 ds50011Minor allele frequency- C:0.03WA 118
    rs8744181,2
    		C,F,A,H--3442069(-) AATGGC/TCCTGC 3 -- us2k1 ds500117Minor allele frequency- T:0.27NS EA NA CSA WA 2877
    rs1875101421,2
    		--3442116(+) ACCCTC/TGGTAC 3 -- ds5001 us2k10--------
    rs7628621,2
    		C,F--3442146(+) TCAGAG/CCATCC 1 -- us2k112Minor allele frequency- C:0.34MN NA WA CSA EA 557

    HapMap Linkage Disequilibrium report for HGFAC (3443614 - 3451213 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for HGFAC
         7 CNVs: 4371 31153 51384 30195 3477 10033 53656

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    Disorders / Diseases
    for HGFAC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HGFAC for disorders           About GeneDecksing

    OMIM gene information: 604552    OMIM disorders: --

    20/27 diseases for HGFAC (see all 27):    About MalaCards
    malignant peripheral nerve sheath tumor    hepatocellular carcinoma (fibrolamellar variant)    diffuse large b-cell lymphoma    b-cell lymphomas
    idiopathic pulmonary fibrosis    pulmonary fibrosis    inflammatory bowel disease    hepatocellular carcinoma
    renal cell carcinoma    multiple myeloma    rheumatoid arthritis    ovarian cancer
    fibrosis    pancreatic cancer    carcinoma    prostate cancer
    breast cancer    myeloma    glioblastoma    prostatitis

    10/19 Novoseek disease relationships for HGFAC gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 37 6 16106403 (2), 11433397 (1), 7556648 (1)
    colorectal carcinoma 35.6 10 11085539 (3), 11436357 (2), 9683286 (1), 10695988 (1)
    pancreatic cancer 23.2 2 18422749 (2)
    adenocarcinoma 14.8 2 15471558 (1)
    prostate cancer 14 5 16005141 (4)
    gastric carcinoma 10.5 2 9346890 (1), 9045658 (1)
    cancer 10.4 8 11562767 (4), 11193201 (1), 19379214 (1)
    tumors 9.96 9 18221492 (1), 12784998 (1), 16189274 (1), 14713848 (1) (see all 7)
    glioma 7.71 2 7556648 (2)
    benign prostatic hyperplasia 7 3 16005141 (2)

    Human Genome Epidemiology (HuGE) Navigator: HGFAC (1 document)

    Export disorders for HGFAC gene to outside databases

    Publications
    for HGFAC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HGFAC gene, integrated from 9 sources (see all 117):
    (articles sorted by number of sources associating them with HGFAC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. (PubMed id 7683665)1, 2, 3, 9 Miyazawa K....Kitamura N. (1993)
    2. Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. (PubMed id 15713485)1, 2, 9 Shia S.... Eigenbrot C. (2005)
    3. Activation of the zymogen of hepatocyte growth factor activator by thrombin. (PubMed id 8226803)1, 3, 9 Shimomura T....Kitamura N. (1993)
    4. Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene -- phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue- type plasminogen activator. (PubMed id 9874200)1, 2, 9 Miyazawa K.... Kitamura N. (1998)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. (PubMed id 18422749)1, 9 Kitajima Y....Miyazaki K. (2008)
    8. Hepatocyte growth factor activator is a serum activat or of single-chain precursor macrophage-stimulating protein. (PubMed id 19456860)1, 9 Kawaguchi M....Kataoka H. (2009)
    9. Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma. (PubMed id 18691255)1, 9 Wader K.F....Waage A. (2008)
    10. Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases. (PubMed id 18221492)1, 9 Mukai S....Kataoka H. (2008)

    External Searches for HGFAC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing HGFAC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3083 HGNC: 4894 AceView: HGFAC Ensembl:ENSG00000109758 euGenes: HUgn3083
    ECgene: HGFAC H-InvDB: HGFAC

    Other Databases showing HGFAC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HGFAC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HGFAC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HGFAC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HGFAC gene:
    Search GeneIP for patents involving HGFAC

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