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Aliases for HGF Gene

Aliases for HGF Gene

  • Hepatocyte Growth Factor 2 3 5
  • Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor) 2 3
  • Fibroblast-Derived Tumor Cytotoxic Factor 2 3
  • Lung Fibroblast-Derived Mitogen 2 3
  • Hepatopoietin-A 3 4
  • Scatter Factor 2 4
  • HPTA 3 4
  • SF 3 4
  • Deafness, Autosomal Recessive 39 2
  • Hepatopoietin A 2
  • EC 3.4.21.7 61
  • EC 3.4.21 61
  • DFNB39 3
  • F-TCF 3
  • HGFB 3

External Ids for HGF Gene

Previous HGNC Symbols for HGF Gene

  • DFNB39

Previous GeneCards Identifiers for HGF Gene

  • GC07M079863
  • GC07M080926
  • GC07M080940
  • GC07M080943
  • GC07M080976
  • GC07M081166
  • GC07M081328
  • GC07M075935

Summaries for HGF Gene

Entrez Gene Summary for HGF Gene

  • This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

CIViC summary for HGF Gene

GeneCards Summary for HGF Gene

HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Dfnb39 Nonsyndromic Hearing Loss And Deafness. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include identical protein binding and serine-type endopeptidase activity. An important paralog of this gene is MST1.

UniProtKB/Swiss-Prot for HGF Gene

  • Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Tocris Summary for HGF Gene

  • The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.

Gene Wiki entry for HGF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HGF Gene

Genomics for HGF Gene

Regulatory Elements for HGF Gene

Enhancers for HGF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G082204 0.8 Ensembl ENCODE 5.5 -434.3 -434309 0.8 BHLHE40 HLF BACH1 NFE2 MAFK NFE2L2 HGF GC07P082036 GC07M082379
GH07G082212 0.2 ENCODE 5.6 -442.3 -442266 1.2 HGF GC07P082036 GC07M082379
GH07G081748 0.3 FANTOM5 2.9 +22.3 22277 0.3 HGF LOC100128317
GH07G081768 0.6 ENCODE 0.7 +0.7 748 3.3 CTCF TAF1 MNT BMI1 REST ZNF398 RAD21 ARID3A SMC3 FOXP2 HGF LOC100128317
GH07G081773 0.4 Ensembl 0.7 -3.1 -3063 0.2 EP300 HGF GC07M081947
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HGF on UCSC Golden Path with GeneCards custom track

Promoters for HGF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214434 838 1601 CTCF TAF1 BMI1 ZNF398 RAD21 ARID3A SMC3 FOXP2

Genomic Location for HGF Gene

Chromosome:
7
Start:
81,699,006 bp from pter
End:
81,770,438 bp from pter
Size:
71,433 bases
Orientation:
Minus strand

Genomic View for HGF Gene

Genes around HGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HGF Gene

Proteins for HGF Gene

  • Protein details for HGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14210-HGF_HUMAN
    Recommended name:
    Hepatocyte growth factor
    Protein Accession:
    P14210
    Secondary Accessions:
    • A1L3U6
    • Q02935
    • Q13494
    • Q14519
    • Q3KRB2
    • Q8TCE2
    • Q9BYL9
    • Q9BYM0
    • Q9UDU6

    Protein attributes for HGF Gene

    Size:
    728 amino acids
    Molecular mass:
    83134 Da
    Quaternary structure:
    • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

    Three dimensional structures from OCA and Proteopedia for HGF Gene

    Alternative splice isoforms for HGF Gene

neXtProt entry for HGF Gene

Selected DME Specific Peptides for HGF Gene

P14210:
  • NYCRNPD
  • PWCFTTDP

Post-translational modifications for HGF Gene

  • Glycosylation at isoforms=3294, isoforms=3402, posLast=476476, isoforms=3566, and posLast=653653
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HGF (HGF)
  • Abcam antibodies for HGF

Assay Products

  • Abcam assays for HGF

Domains & Families for HGF Gene

Gene Families for HGF Gene

Suggested Antigen Peptide Sequences for HGF Gene

Graphical View of Domain Structure for InterPro Entry

P14210

UniProtKB/Swiss-Prot:

HGF_HUMAN :
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
Family:
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
genes like me logo Genes that share domains with HGF: view

Function for HGF Gene

Molecular function for HGF Gene

GENATLAS Biochemistry:
hepatocyte growth factor,precursor of chains alpha and beta,expressed in platelets,fibroblast,macrophage,endothelial and smooth muscle cells
UniProtKB/Swiss-Prot Function:
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Enzyme Numbers (IUBMB) for HGF Gene

LifeMap Function Summary for HGF Gene

Gene Ontology (GO) - Molecular Function for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 NOT serine-type endopeptidase activity NAS 2531289
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 1846706
GO:0008083 growth factor activity NAS 2531289
genes like me logo Genes that share ontologies with HGF: view
genes like me logo Genes that share phenotypes with HGF: view

Human Phenotype Ontology for HGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HGF Gene

MGI Knock Outs for HGF:

Animal Model Products

miRNA for HGF Gene

miRTarBase miRNAs that target HGF

Clone Products

  • Addgene plasmids for HGF

No data available for Transcription Factor Targets and HOMER Transcription for HGF Gene

Localization for HGF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HGF gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
mitochondrion 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0016020 membrane IDA 19946888
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with HGF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HGF Gene

Pathways & Interactions for HGF Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PEDF Induced Signaling
4 GAB1 signalosome
5 MET promotes cell motility
genes like me logo Genes that share pathways with HGF: view

SIGNOR curated interactions for HGF Gene

Activates:

Gene Ontology (GO) - Biological Process for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IEA --
GO:0000278 mitotic cell cycle NAS 2531289
GO:0000902 cell morphogenesis IEA --
GO:0001837 epithelial to mesenchymal transition TAS 14679171
genes like me logo Genes that share ontologies with HGF: view

Drugs & Compounds for HGF Gene

(120) Drugs for HGF Gene - From: DrugBank, ClinicalTrials, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist 2171
Bortezomib Approved, Investigational Pharma Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 807
Phenytoin Approved, Vet_approved Pharma Pore Blocker 77
Crizotinib Approved Pharma C-MET/ALK inhibitor,potent and ATP-competitve, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor, Potent c-MET/ALK inhibitor 104

(59) Additional Compounds for HGF Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PF 04217903 mesylate
956906-93-7

(5) Tocris Compounds for HGF Gene

Compound Action Cas Number
Crizotinib Potent c-MET/ALK inhibitor 877399-52-5
PF 04217903 mesylate Highly selective MET inhibitor 956906-93-7
PHA 665752 Potent and selective MET inhibitor 477575-56-7
SU 11274 Selective inhibitor of MET kinase activity 658084-23-2
SU 5416 VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 204005-46-9
genes like me logo Genes that share compounds with HGF: view

Transcripts for HGF Gene

Unigene Clusters for HGF Gene

Hepatocyte growth factor (hepapoietin A; scatter factor):
Representative Sequences:

Clone Products

  • Addgene plasmids for HGF

Alternative Splicing Database (ASD) splice patterns (SP) for HGF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for HGF Gene

GeneLoc Exon Structure for
HGF
ECgene alternative splicing isoforms for
HGF

Expression for HGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HGF Gene

This gene is overexpressed in Liver (x5.3).

Protein differential expression in normal tissues from HIPED for HGF Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.1), Amniocyte (24.6), and Placenta (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HGF Gene



NURSA nuclear receptor signaling pathways regulating expression of HGF Gene:

HGF

SOURCE GeneReport for Unigene cluster for HGF Gene:

Hs.396530

Evidence on tissue expression from TISSUES for HGF Gene

  • Liver(4.7)
  • Blood(4.5)
  • Lung(4.5)
  • Nervous system(4.5)
  • Kidney(3)
  • Heart(2.8)
  • Intestine(2.7)
  • Bone marrow(2.6)
  • Muscle(2.5)
  • Skin(2.3)
  • Eye(2.2)
  • Stomach(2.1)
  • Lymph node(2)
  • Pancreas(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HGF Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • inner ear
  • middle ear
  • outer ear
  • skull
General:
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with HGF: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HGF Gene

Orthologs for HGF Gene

This gene was present in the common ancestor of animals.

Orthologs for HGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HGF 34 35
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia HGF 34 35
  • 92.76 (n)
dog
(Canis familiaris)
Mammalia HGF 34 35
  • 92.49 (n)
oppossum
(Monodelphis domestica)
Mammalia HGF 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hgf 34 16 35
  • 88.51 (n)
rat
(Rattus norvegicus)
Mammalia Hgf 34
  • 88.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HGF 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves HGF 34
  • 76.87 (n)
HGF/SF 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HGF 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hgf 34
  • 70.63 (n)
zebrafish
(Danio rerio)
Actinopterygii hgfa 34 35
  • 55.29 (n)
HGF (2 of 2) 35
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tequila 35
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea svh-1 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
ManyToMany
-- 35
  • 18 (a)
ManyToMany
Species where no ortholog for HGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HGF Gene

ENSEMBL:
Gene Tree for HGF (if available)
TreeFam:
Gene Tree for HGF (if available)

Paralogs for HGF Gene

Paralogs for HGF Gene

(7) SIMAP similar genes for HGF Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for HGF Gene

genes like me logo Genes that share paralogs with HGF: view

Variants for HGF Gene

Sequence variations from dbSNP and Humsavar for HGF Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs137853235 Pathogenic 81,752,250(-) CCTTC(A/G)AGCTA intron-variant, reference, synonymous-codon
rs145494248 Likely benign 81,705,509(+) TGCCA(C/T)TCGTA reference, missense
rs1800793 Likely benign 81,717,369(-) TTTCC(A/G/T)CAGTC intron-variant
rs546227025 Likely benign 81,726,029(+) AGAAT(A/G)AGCAT intron-variant
rs5745635 Likely benign 81,758,726(-) AAAGA(A/G)TTTGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HGF Gene

Variant ID Type Subtype PubMed ID
dgv1101e201 CNV deletion 23290073
dgv3601n106 CNV deletion 24896259
esv2384607 CNV deletion 18987734
esv2618632 CNV deletion 19546169
esv2734743 CNV deletion 23290073
esv3541994 CNV deletion 23714750
esv3576398 CNV gain 25503493
esv3613890 CNV loss 21293372
esv3613891 CNV loss 21293372
esv3807 CNV loss 18987735
esv8642 CNV loss 19470904
nsv1019753 CNV gain 25217958
nsv1074527 CNV deletion 25765185
nsv1124235 CNV deletion 24896259
nsv1150903 CNV deletion 26484159
nsv366332 CNV deletion 16902084
nsv464609 CNV loss 19166990
nsv607689 CNV loss 21841781
nsv951366 CNV duplication 24416366
nsv955962 CNV deletion 24416366

Variation tolerance for HGF Gene

Residual Variation Intolerance Score: 8.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HGF Gene

Human Gene Mutation Database (HGMD)
HGF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HGF Gene

Disorders for HGF Gene

MalaCards: The human disease database

(49) MalaCards diseases for HGF Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 39
  • autosomal recessive nonsyndromic deafness 39
dfnb39 nonsyndromic hearing loss and deafness
  • dfnb 39 nonsyndromic hearing loss and deafness
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
critical limb ischemia
  • cli
acute kidney failure
  • renal failure acute
- elite association - COSMIC cancer census association via MalaCards
Search HGF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HGF_HUMAN
  • Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:19576567}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HGF

Genetic Association Database (GAD)
HGF
Human Genome Epidemiology (HuGE) Navigator
HGF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HGF
genes like me logo Genes that share disorders with HGF: view

No data available for Genatlas for HGF Gene

Publications for HGF Gene

  1. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. (PMID: 19576567) Schultz J.M. … Morell R.J. (Am. J. Hum. Genet. 2009) 2 3 4 64
  2. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. (PMID: 15167892) Stamos J. … Wiesmann C. (EMBO J. 2004) 3 4 22 64
  3. The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. (PMID: 9493272) Zhou H. … Byrd R.A. (Structure 1998) 3 4 22 64
  4. Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution. (PMID: 9817840) Ultsch M. … de Vos A.M. (Structure 1998) 3 4 22 64
  5. Organization of the human hepatocyte growth factor-encoding gene. (PMID: 1831432) Seki T. … Shimizu S. (Gene 1991) 3 4 22 64

Products for HGF Gene

  • Addgene plasmids for HGF

Sources for HGF Gene

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