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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HGF Gene

protein-coding GIFtS: 72
GCID: GC07M081328

hepatocyte growth factor (hepapoietin A; scatter factor)

(Previous names: deafness, autosomal recessive 39 )
(Previous symbol: DFNB39)

Explore 235 diseases affiliated with
HGF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)¹ ²		Hepatocyte Growth Factor²
HPTA¹ ² ³		Hepatopoeitin-A¹
SF¹ ² ³		Hepatopoietin-A³
DFNB39¹ ² ⁵		Lung Fibroblast-Derived Mitogen²
F-TCF¹ ²		Hepatopoietin-A³
HGFB¹ ²		Scatter Factor³
Deafness, Autosomal Recessive 39¹		EC 3.4.21⁸
Fibroblast-Derived Tumor Cytotoxic Factor²		EC 3.4.21.7⁸

External Ids:	HGNC: 4893¹	Entrez Gene: 3082²	Ensembl: ENSG00000019991⁷	OMIM: 142409⁵	UniProtKB: P14210³

Export aliases for HGF gene to outside databases

Previous GC identifers: GC07M079863 GC07M080926 GC07M080940 GC07M080943 GC07M080976 GC07M081166 GC07M075935

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HGF:

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase

signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by

mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to

stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and

tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa

alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active,

heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable

protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different

isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210

Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a

growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET

by binding to it and promoting its dimerization

summary for HGF:

MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a

proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter

factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the

adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and

hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are

essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of

the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it

can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for HGF (Hepatocyte growth factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HGF gene promoter:
AP-1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HGF promoter sequence

Search SABiosciences Chromatin IP Primers for HGF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HGF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1 Ensembl cytogenetic band: 7q21.11 HGNC cytogenetic band: 7q21.1

HGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HGF gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M081328: view genomic region (about GC identifiers)

Start:	81,328,322 bp from pter	End:	81,399,754 bp from pter
Size:	71,433 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 80,663,506-80,731,238

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210 (See protein sequence)

Recommended Name: Hepatocyte growth factor precursor

Size: 728 amino acids; 83134 Da

Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond

Caution: Has lost two of the three essential catalytic residues and so probably has no enzymatic activity

6/14 PDB 3D structures from and Proteopedia for HGF (see all 14):

1BHT (3D)

1GMN (3D)

1GMO (3D)

1GP9 (3D)

1NK1 (3D)

1SHY (3D)

Secondary accessions: A1L3U6 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6

Alternative splicing: 6 isoforms: P14210-1 P14210-2 P14210-3 P14210-4 P14210-5 P14210-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HGF: NX_P14210

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P14210

2 DME Specific Peptides for HGF (P14210)

NYCRNPD

PWCFTTDP

HGF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_000592.3 NP_001010931.1 NP_001010932.1 NP_001010933.1 NP_001010934.1

ENSEMBL proteins:

ENSP00000222390 ENSP00000391238 ENSP00000389854 ENSP00000408270 ENSP00000413829

ENSP00000395468 ENSP00000396307 ENSP00000388592 ENSP00000346164

Reactome Protein details: P14210
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for HGF
	Novus Biologicals HGF Proteins Novus Biologicals HGF Lysates
	Sino Biological Recombinant Protein for HGF
	ProSpec Recombinant Protein for HGF
	Uscn Proteins for HGF

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0031093	platelet alpha granule lumen	TAS	--

HGF for ontologies About GeneDecksing

HGF Antibody Products:

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	Novus Biologicals HGF Antibodies
	Search for Antibodies for HGF at Abcam
	Uscn Antibodies for HGF
	ThermoFisher Antibodies for HGF

Assay Products for HGF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for HGF (see all)
	GenScript Custom Assay Services for HGF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HGF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGF for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR001314 Peptidase_S1A

IPR018056 Kringle_CS

IPR001254 Peptidase_S1

IPR024174 HGF_MST1

IPR027284 Hepatocyte_GF

Graphical View of Domain Structure for InterPro Entry P14210

ProtoNet protein and cluster: P14210

5 Blocks protein families:

IPB000001 Kringle

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB003014 N/apple PAN

IPB003609 Apple-like

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210

Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily

Similarity: Contains 4 kringle domains

Similarity: Contains 1 PAN domain

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210

Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a

growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET

by binding to it and promoting its dimerization

Genatlas biochemistry entry for HGF:

hepatocyte growth factor,precursor of chains alpha and beta,expressed in platelets,fibroblast,macrophage,endothelial

and smooth muscle cells

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.7²

Summary:

During embryonic development, HGF as signaling molecule is secreted from the following cells: Progress Zone Cells in Limb Bud, Septum Transversum Mesenchyme Cells in Septum Transversum (see all 3).

It affects the following cells: Hepatoblasts in Liver Bud, Hepatoblasts in Liver Bud (see all 7).

HGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Immature hepatocytes, Epithelial Podocyte-like cells (see all 8).

miRNA Products:		OriGene 3'-UTR Clone (see all 5): HGF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HGF
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate HGF (see all 12):
		hsa-miR-200a hsa-miR-888* hsa-miR-1297 hsa-miR-146a* hsa-miR-141 hsa-miR-374a* hsa-miR-141* hsa-miR-1244

		SwitchGear 3'UTR luciferase reporter plasmid: HGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HGF (see all 7) OriGene shRNA RFP: HGF Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HGF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HGF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 5): HGF (NM_000601)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HGF
		Search LifeMap BioReagents cell lines for HGF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGF

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	NOT serine-type endopeptidase activity	NAS	2531289
GO:0005515	protein binding	IPI	--
GO:0008083	growth factor activity	NAS	2531289
GO:0042056	chemoattractant activity	IDA	--
GO:0042802	identical protein binding	IPI	--

HGF for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for HGF: Hgf^tm1Kita Hgf^tm1Cbm
     8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Hgf):

cardiovascular system	cellular	embryogenesis	growth/size	hematopoietic system
liver/biliary system	mortality/aging	no phenotypic analysis

HGF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/33 super-pathways (see all 33) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

PEDF Induced Signaling

8/9 pathways (see all 9)
PEDF Induced Signaling	1.00	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Mediated Glucocorticoid Regulation	0.73	STAT3 Pathway	0.47
MIF Regulation of Innate Immune Cells	0.71	Endothelin-1 Signaling Pathway	0.44
IL-6 Pathway	0.61	Cytokine-cytokine receptor interaction	0.26

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Development HGF signaling pathway

	Development HGF signaling pathway	1.00			Signaling of Hepatocyte Growth Factor Receptor	0.35
	Development_HGF signaling pathway	0.78			Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.23

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for HGF

	Development HGF signaling pathway
	Cell adhesion PLAU signaling

5/64 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HGF (see all 64)

	Telomerase Components in Cell Signaling
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	JNK Pathway

2 GeneGo (Thomson Reuters) Pathways for HGF

	Cell adhesion PLAU signaling
	Development HGF signaling pathway

5/9 BioSystems Pathways for HGF (see all 9)

	Focal Adhesion
	Signaling events mediated by TCPTP
	Signaling of Hepatocyte Growth Factor Receptor
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Direct p53 effectors

5/8 Reactome Pathways for HGF (see all 8)

	Hemostasis
	Interleukin-7 signaling
	Cytokine Signaling in Immune system
	Platelet degranulation
	Signaling by Interleukins

5/6 Kegg Pathways (Kegg details for HGF) (see all 6):

	Cytokine-cytokine receptor interaction
	Focal adhesion
	Malaria
	Pathways in cancer
	Renal cell carcinoma

HGF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HGF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for HGF (P14210^{1, 2, 3} ENSP00000222390⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MET	P08581¹^,³, ENSP00000317272⁴	EBI-6280319,EBI-1039152 I2D: score=4 STRING: ENSP00000317272
FN1	P02751³, ENSP00000346839⁴	I2D: score=1 STRING: ENSP00000346839
HPN	P05981³, ENSP00000262626⁴	I2D: score=1 STRING: ENSP00000262626
KLKB1	P03952³, ENSP00000264690⁴	I2D: score=1 STRING: ENSP00000264690
LCN2	P80188³, ENSP00000277480⁴	I2D: score=1 STRING: ENSP00000277480

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IEA	--
GO:0000902	cell morphogenesis	--	--
GO:0001837	epithelial to mesenchymal transition	TAS	14679171
GO:0001889	liver development	IEA	--
GO:0002576	platelet degranulation	TAS	--

HGF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HGF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for HGF available from Tocris Bioscience About this table

Compound	Action	CAS #
PHA 665752	Potent and selective MET inhibitor	[477575-56-7]
K 252a	Protein kinase inhibitor	[99533-80-9]

2 DrugBank Compounds for HGF About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
N,O6-Disulfo-Glucosamine	--	--	target	--	17139284 17016423
O2-Sulfo-Glucuronic Acid	--	--	target	--	17139284 17016423

10/144 Novoseek chemical compound relationships for HGF gene (see all 144) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	77.7	432	8601419 (4), 10644987 (4), 7475949 (4), 10521801 (3) (see all 99)
vegf	77.7	523	18664639 (8), 11289497 (8), 16728464 (6), 17234170 (6) (see all 99)
matrigel	68	43	15333517 (2), 9624561 (2), 15042617 (2), 10496342 (2) (see all 30)
ly294002	57.3	11	12611639 (3), 17594810 (2), 18262389 (1), 17055484 (1) (see all 6)
phosphatidylinositol	56.5	21	10763917 (2), 10362361 (1), 10739674 (1), 12531429 (1) (see all 18)
pd 98,059	51.4	13	11057428 (2), 10362361 (1), 14598883 (1), 15672871 (1) (see all 12)
wortmannin	50.8	12	10362361 (1), 15781227 (1), 18579758 (1), 15452053 (1) (see all 9)
anit	49.1	12	9548396 (2), 1427661 (2), 19040928 (1), 1446596 (1)
serine	46.9	86	17372204 (3), 15172968 (3), 20015050 (2), 11164712 (2) (see all 54)
heparin	44.4	156	9254627 (8), 8288571 (7), 8262149 (6), 8138538 (6) (see all 49)

Search CenterWatch for drugs/clinical trials and news about HGF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HGF gene (5 alternative transcripts):

NM_000601.4 NM_001010931.1 NM_001010932.1 NM_001010933.1 NM_001010934.1

Unigene Cluster for HGF:

Hepatocyte growth factor (hepapoietin A; scatter factor)

Hs.396530 [show with all ESTs]

Unigene Representative Sequence: AK291674

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000222390(uc003uhl.3 uc003uhm.3) ENST00000457544 ENST00000444829(uc003uhn.1 uc003uho.1)

ENST00000453411 ENST00000423064(uc003uhp.3) ENST00000465234 ENST00000453018

ENST00000412881 ENST00000421558 ENST00000354224(uc022agw.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HGF
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate HGF (see all 12):
		hsa-miR-200a hsa-miR-888* hsa-miR-1297 hsa-miR-146a* hsa-miR-141 hsa-miR-374a* hsa-miR-141* hsa-miR-1244

		SwitchGear 3'UTR luciferase reporter plasmid: HGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HGF (see all 7) OriGene shRNA RFP: HGF Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HGF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HGF (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HGF (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): HGF (NM_000601)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HGF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HGF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HGF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HGF

Additional cDNA sequence:

AB208900.1 AK291674.1 AK313694.1 BC022308.1 BC063485.1 BC105797.1 BC130284.1 BC130286.1

FJ830861.1 FJ830862.1 L02931.1 M29145.1 M55379.1 M60718.1 M73239.1 M73240.1

M77227.1 U46010.1 X57574.1

7 DOTS entries:

DT.314366 DT.75162211 DT.86846785 DT.40223084 DT.100709074 DT.100738092 DT.121113589

24/85 AceView cDNA sequences (see all 85):

M60718 BE326846 CR600867 L02931 AI206848 NM_000601 M55379 CN483847

M29145 M73239 BU625850 AL546558 CR593759 BG572225 BM691444 AJ713089

AL546825 U46010 BE244598 AW276331 BG571792 AV759905 M73240 BI915528

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HGF About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:																					-
SP2:											-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for HGF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HGF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCCCTTA

About this image

HGF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone, Cartilage

Liver

Sinusoidal Endothelial Cells

Endothelium

Lung

Lung Mesoderm

Early Lung Mesoderm Cells

Lung

Mesoderm

Septum Transversum

Septum Transversum Mesenchyme Cells

Early Embryo, Mesoderm

Bone

Mandibular Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

Mesenchymal Precursor Cells (STRO-3 selected) (Adult Stem / Progenitor Cell)

Bone

mK3 (Cell line)

Kidney

mK4 (Cell line)

Kidney

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

Trophoblast-like cells (Generation of tropho...)

Beating cell clusters (Spontaneous differen...)

See HGF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HGF

SOURCE GeneReport for Unigene cluster: Hs.396530

SABiosciences Expression via Pathway-Focused PCR Arrays including HGF (see all 12):

Oncogenes & Tumor Suppressor Genes in human mouse rat

Lung Cancer in human mouse rat

Growth Factors in human mouse rat

Fibrosis in human mouse rat

Angiogenic Growth Factors in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HGF gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HGF¹	hepatocyte growth factor (hepapoietin A; scatter factor)	76.87(n) 75.48(a)		395941 NM_001030370.2 NP_001025541.2
lizard (Anolis carolinensis)	Reptilia	HGF⁶	--	66(a)	1 ↔ 1	5(92481221-92542103)
zebrafish (Danio rerio)	Actinopterygii	hgfa¹	hepatocyte growth factor a	55.09(n) 49.55(a)		493781 NM_001013274.1 NP_001013292.1
honey bee (Apis mellifera)	Insecta	--	--	10(a)	possible ortholog	GroupUn.841(30640-42833)

ENSEMBL Gene Tree for HGF (if available)
TreeFam Gene Tree for HGF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HGF gene

KREMEN1² KREMEN2² PLAT² PLG² HGFAC² LPA² PLAU² HABP2²

MST1² F12² MST1L²

7 SIMAP similar genes for HGF using alignment to 6 protein entries: HGF_HUMAN (see all proteins):

PLAT MST1 F2 APOA PLG MST1L

KLK9

HGF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10654214^1,2	C,	--	75981727(+)	`CCTCTAAAAC/- aaaac`	4	--	int¹		1	NA	2
rs75716542^1,2	F,	--	80663347(+)	`ATTTAG/CGGGTT`	2	--	ds500¹		1	WA	118
rs5745769^1,2	C,F	--	80663432(-)	`CACACTT/-TTTAC`	2	--	ds500¹		1	NS	180
rs5745768^1,2	C,F,H,	--	80663492(-)	`ATGTTA/GTAGTT`	2	--	ds500¹		9	NS NA WA	1092
rs5745766^1,2	C,F,	--	80664213(-)	`AGATGC/AAAATC`	2	--	int¹		5	NS NA WA	302
rs5745764^1,2	C,	--	80664295(-)	`AAGTCA/GACAAA`	2	--	int¹		2	NS WA	294
rs5745761^1,2	C,F,	--	80665609(-)	`ACTTCC/TCTCTT`	2	--	int¹ trp³		2	NS NA	288
rs5745760^1,2	C,F,	--	80665681(-)	`ATTACC/TAAAAC`	2	--	int¹		9	NS WA	950
rs5745759^1,2	C,F,	--	80665985(-)	`CAAGTG/ATTATA`	2	--	int¹		5	NS NA WA	304
rs5745758^1,2	C,F,	--	80666240(-)	`GGACAT/GTTCAT`	2	--	int¹		2	NS CSA	176

HapMap Linkage Disequilibrium report for HGF (81328322 - 81399754 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for HGF
1 CNV: 100003
5 Indels: 40996 12940 41808 47396 62681
Human Gene Mutation Database (HGMD): HGF

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HGF for disorders           About GeneDecksing

OMIM gene information: 142409
OMIM disorders: 608265
UniProtKB/Swiss-Prot: HGF_HUMAN, P14210

Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:608265]. A form of profound

prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner

ear, the nerve pathways to the brain, or the area of the brain that receives sound information

20/235 diseases for HGF (see all 235): About MalaCards

deafness, autosomal recessive 39 angle-closure glaucoma primary angle-closure glaucoma glycogen storage disease type ia

spinal cord injury adult-onset still's disease malignant peripheral nerve sheath tumor spinal cord ischemia

salivary gland cancer hepatocellular carcinoma (fibrolamellar variant) diffuse large b-cell lymphoma disseminated intravascular coagulation

doxorubicin induced cardiomyopathy proliferative diabetic retinopathy glycogen storage disease deep vein thrombosis

amyotrophic lateral sclerosis (als) arteriosclerosis obliterans fibrous histiocytoma graft versus host disease

5 diseases from the University of Copenhagen DISEASES database for HGF:

Cancer Liver disease Vascular disease Kidney failure

Myocardial infarction

10/97 Novoseek disease relationships for HGF gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arteriosclerosis retinal	68.5	7	9721534 (1), 9350587 (1), 10404823 (1), 9311255 (1)
tumors	65.5	773	10810432 (6), 16945480 (6), 7853418 (6), 9788258 (5) (see all 99)
metastasis	62.2	234	15492787 (4), 14598883 (3), 11118060 (3), 15221009 (3) (see all 99)
hepatocellular carcinoma	60.3	123	11211911 (6), 11264569 (5), 8778194 (4), 15359093 (4) (see all 63)
renal fibrosis	59.8	28	14638904 (4), 15180923 (3), 11593360 (3), 16838037 (1) (see all 16)
hepatic failure fulminant	59.1	38	19624764 (3), 2142004 (2), 9286233 (2), 1827762 (2) (see all 26)
cancer	55.4	308	15607934 (5), 11477552 (4), 11328532 (3), 12536083 (3) (see all 99)
liver diseases	50.2	57	10220746 (4), 1833258 (3), 7806142 (2), 10594807 (2) (see all 35)
arteriosclerosis obliterans	50.1	8	10373220 (2), 10429451 (1), 15238569 (1), 19225945 (1)
neovascularization	49.3	24	12414523 (2), 8780385 (1), 10408347 (1), 17179234 (1) (see all 17)

Genetic Association Database (GAD): HGF
Human Genome Epidemiology (HuGE) Navigator: HGF (1257 documents)

Export disorders for HGF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HGF gene, integrated from 9 sources (see all 2184):
(articles sorted by number of sources associating them with HGF)

Utopia: connect your pdf to the dynamic
world of online information

Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. (PubMed id 19576567)^{1, 2, 3} Schultz J.M.... Morell R.J. (2009)
The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. (PubMed id 9493272)^{1, 2, 9} Zhou H.... Byrd R.A. (1998)
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. (PubMed id 15167892)^{1, 2, 9} Stamos J....Wiesmann C. (2004)
Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. (PubMed id 15064106)^{1, 4, 9} Takiuchi S....Tomoike H. (2004)
Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution. (PubMed id 9817840)^{1, 2, 9} Ultsch M.... de Vos A.M. (1998)
Organization of the human hepatocyte growth factor-encoding gene. (PubMed id 1831432)^{1, 2, 9} Seki T.... Shimizu S. (1991)
Assignment of the hepatocyte growth factor (HGF) to chromosome 7q22-qter. (PubMed id 1837206)^{1, 3, 9} Laguda B....Spurr N.K. (1991)
Evidence for the identity of human scatter factor and human hepatocyte growth factor. (PubMed id 1831266)^{1, 2, 9} Weidner K.M....Birchmeier W. (1991)
Association between hepatocyte growth factor gene polymorphism and essential hypertension. (PubMed id 15127882)^{1, 4} Motone M....Ogihara T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3082	HGNC: 4893	AceView: HGF	Ensembl:ENSG00000019991	euGenes: HUgn3082
ECgene: HGF	Kegg: 3082	H-InvDB: HGF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HGF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HGF	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hgf/
Wikipedia	http://en.wikipedia.org/wiki/Hepatocyte_growth_factor

Intellectual Property for HGF gene
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Patent Information for HGF gene:
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GeneCards and IP:
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HGF Gene

hepatocyte growth factor (hepapoietin A; scatter factor)

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LUNG TUMOR
Renal Cancer
Hepatitis Chronic
Endometriosis
aggressiveness
ADENOCARCINOMA LUNG
LUNG CARCINOMA
Multiple tumors
LIVER MASS
Vitreoretinopathy Proliferative
Lymphatic Metastasis
Ischemia
Liver diseases
Breast Cancer
Neovascularization
primary tumor
NSCLC
Adenocarcinoma
Sarcoma 180
Cancer
NEPHROPATHY OBSTRUCTIVE
TUBULAR NECROSIS ACUTE
HEPATITIS FULMINANT
ADENOCARCINOMA GASTRIC
Pathological Processes
Carcinoma Non-Small Cell Lung
GASTRIC CARCINOMA
infectious gastroenteritis
Ovarian Cancer
RENAL DISEASE
Bronchoalveolar Lavage Fluid
Liver Failure
Colorectal Cancer
HNSCC
glomerulosclerosis
Inflammation
TUMOR LIVER
Hepatitis
Liver Failure Acute
MYELOMA
LIVER DAMAGE
hypopharyngeal squamous cell carcinoma
prostate cancer
Tumors
Malignant mesothelioma
Metastasis
Hepatic Failure Fulminant
Necrosis
Liver Cirrhosis
Renal Failure Acute
Hepatoblastoma
Glioblastoma
Carotid Atherosclerosis
Malignant Glioma
FIBROSIS IDIOPATHIC PULMONARY
Gastric Cancer
Cirrhosis
BREAST CARCINOMA
Melanoma
Colon Cancer
Medulloblastoma
Pulmonary Fibrosis
Adenoma Follicular
Glioma
ARTERIOSCLEROSIS RETINAL
Liver Fibrosis
RENAL INTERSTITIAL FIBROSIS
Carcinoma
Polycystic Kidney Diseases
Renal fibrosis
Carcinoma Papillary
Short Bowel Syndrome
HEPATOCELLULAR CARCINOMA
Arteriosclerosis
Biliary Atresia
THYROID PAPILLARY CARCINOMA
Epiretinal Membrane
Carcinoma Renal Cell
Pancreatic Cancer
Cancer Lung
gastric ulcer
Salivary Gland Cancer
Sarcoma Synovial
Proliferative diabetic retinopathy
Liver Dysfunction
Cholangiocarcinoma
mesothelioma
solid tumor
Carcinoma Squamous Cell
Retinal Neovascularization
Portal cirrhosis
acute alcoholic hepatitis
PANCREATIC CARCINOMA
Arteriosclerosis Obliterans
chronic liver disease
ENDOMETRIOSIS PELVIC
Renal Failure Chronic

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HGF Gene

hepatocyte growth factor (hepapoietin A; scatter factor)

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