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Aliases for HGF Gene

Aliases for HGF Gene

  • Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor) 2 3
  • Fibroblast-Derived Tumor Cytotoxic Factor 2 3
  • Lung Fibroblast-Derived Mitogen 2 3
  • Hepatopoietin-A 3 4
  • Scatter Factor 2 4
  • DFNB39 3 6
  • HPTA 3 4
  • SF 3 4
  • Deafness, Autosomal Recessive 39 2
  • Hepatocyte Growth Factor 3
  • Hepatopoietin A 2
  • Hepatopoeitin-A 3
  • EC 3.4.21.7 64
  • EC 3.4.21 64
  • F-TCF 3
  • HGFB 3

External Ids for HGF Gene

Previous Symbols for HGF Gene

  • DFNB39

Summaries for HGF Gene

Entrez Gene Summary for HGF Gene

  • Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for HGF Gene

HGF (Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)) is a Protein Coding gene. Diseases associated with HGF include deafness, autosomal recessive 39 and dfnb39 nonsyndromic hearing loss and deafness. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include identical protein binding and growth factor activity. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for HGF Gene

  • Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Tocris Summary for HGF Gene

  • MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for HGF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HGF Gene

Genomics for HGF Gene

Genomic Location for HGF Gene

Start:
81,699,006 bp from pter
End:
81,770,438 bp from pter
Size:
71,433 bases
Orientation:
Minus strand

Genomic View for HGF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HGF Gene

Regulatory Elements for HGF Gene

Proteins for HGF Gene

  • Protein details for HGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14210-HGF_HUMAN
    Recommended name:
    Hepatocyte growth factor
    Protein Accession:
    P14210
    Secondary Accessions:
    • A1L3U6
    • Q02935
    • Q13494
    • Q14519
    • Q3KRB2
    • Q8TCE2
    • Q9BYL9
    • Q9BYM0
    • Q9UDU6

    Protein attributes for HGF Gene

    Size:
    728 amino acids
    Molecular mass:
    83134 Da
    Quaternary structure:
    • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

    Three dimensional structures from OCA and Proteopedia for HGF Gene

    Alternative splice isoforms for HGF Gene

neXtProt entry for HGF Gene

Proteomics data for HGF Gene at MOPED

Selected DME Specific Peptides for HGF Gene

Post-translational modifications for HGF Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn294, Asn402, Thr476, Asn566, and Asn653

Domains for HGF Gene

UniProtKB/Swiss-Prot:

HGF_HUMAN
Domain:
  • Contains 4 kringle domains.:
    • P14210
  • Contains 1 PAN domain.:
    • P14210
  • Contains 1 peptidase S1 domain.:
    • P14210
Family:
  • Belongs to the peptidase S1 family. Plasminogen subfamily.:
    • P14210
genes like me logo Genes that share domains with HGF: view

No data available for Gene Families for HGF Gene

Function for HGF Gene

Molecular function for HGF Gene

GENATLAS Biochemistry: hepatocyte growth factor,precursor of chains alpha and beta,expressed in platelets,fibroblast,macrophage,endothelial and smooth muscle cells
UniProtKB/Swiss-Prot Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Enzyme Numbers (IUBMB) for HGF Gene

Gene Ontology (GO) - Molecular Function for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 NOT serine-type endopeptidase activity NAS 2531289
GO:0005515 protein binding IPI 12694198
GO:0008083 growth factor activity NAS 2531289
GO:0042056 chemoattractant activity IDA 21245381
genes like me logo Genes that share ontologies with HGF: view
genes like me logo Genes that share phenotypes with HGF: view

Animal Models for HGF Gene

MGI Knock Outs for HGF:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for HGF Gene

Localization for HGF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HGF Gene COMPARTMENTS Subcellular localization image for HGF gene
Compartment Confidence
extracellular 4
cytoskeleton 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0016020 membrane IDA 19946888
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with HGF: view

Pathways for HGF Gene

genes like me logo Genes that share pathways with HGF: view

Gene Ontology (GO) - Biological Process for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0000902 cell morphogenesis --
GO:0001837 epithelial to mesenchymal transition TAS 14679171
GO:0001889 liver development IEA --
GO:0002576 platelet degranulation TAS --
genes like me logo Genes that share ontologies with HGF: view

Compounds for HGF Gene

(4) Tocris Compounds for HGF Gene

Compound Action Cas Number
Crizotinib Potent c-MET/ALK inhibitor [877399-52-5]
PF 04217903 mesylate Highly selective c-Met inhibitor [956906-93-7]
PHA 665752 Potent and selective MET inhibitor [477575-56-7]
SU 11274 Selective inhibitor of MET kinase activity [658084-23-2]

(2) Drugbank Compounds for HGF Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N,O6-Disulfo-Glucosamine
target
O2-Sulfo-Glucuronic Acid
target

(144) Novoseek inferred chemical compound relationships for HGF Gene

Compound -log(P) Hits PubMed IDs
tyrosine 77.7 137
vegf 77.7 263
matrigel 68 37
ly294002 57.3 9
phosphatidylinositol 56.5 19
genes like me logo Genes that share compounds with HGF: view

Transcripts for HGF Gene

Unigene Clusters for HGF Gene

Hepatocyte growth factor (hepapoietin A; scatter factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HGF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for HGF Gene

GeneLoc Exon Structure for
HGF
ECgene alternative splicing isoforms for
HGF

Expression for HGF Gene

mRNA expression in normal human tissues for HGF Gene

mRNA differential expression in normal tissues according to GTEx for HGF Gene

This gene is overexpressed in Liver (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HGF Gene

SOURCE GeneReport for Unigene cluster for HGF Gene Hs.396530

genes like me logo Genes that share expressions with HGF: view

Orthologs for HGF Gene

This gene was present in the common ancestor of animals.

Orthologs for HGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HGF 36
  • 99.91 (n)
  • 99.86 (a)
HGF 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HGF 36
  • 92.76 (n)
  • 93.4 (a)
HGF 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HGF 36
  • 92.49 (n)
  • 92.72 (a)
HGF 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hgf 36
  • 88.51 (n)
  • 91.03 (a)
Hgf 16
Hgf 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HGF 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HGF 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hgf 36
  • 88.09 (n)
  • 90.62 (a)
chicken
(Gallus gallus)
Aves HGF 36
  • 76.87 (n)
  • 75.35 (a)
HGF/SF 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HGF 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hgf 36
  • 70.63 (n)
  • 68.77 (a)
zebrafish
(Danio rerio)
Actinopterygii HGF (2 of 2) 37
  • 53 (a)
OneToMany
hgfa 36
  • 55.29 (n)
  • 49.55 (a)
hgfa 37
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tequila 37
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea svh-1 37
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
Species with no ortholog for HGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HGF Gene

ENSEMBL:
Gene Tree for HGF (if available)
TreeFam:
Gene Tree for HGF (if available)

Paralogs for HGF Gene

Paralogs for HGF Gene

Selected SIMAP similar genes for HGF Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HGF: view

Variants for HGF Gene

Sequence variations from dbSNP and Humsavar for HGF Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3336 -- 81,754,864(+) ACACA(A/C)AAAGC intron-variant
rs17566 - 81,757,213(-) CTGGA(G/T)TTCCA reference, missense
rs718837 -- 81,715,786(-) AATGT(G/T)GCTTT intron-variant
rs725349 -- 81,712,546(-) AGAGA(C/T)GAAAA intron-variant
rs757830 -- 81,733,068(+) TTATG(C/T)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HGF Gene

Variant ID Type Subtype PubMed ID
nsv888562 CNV Loss 21882294
esv2618632 CNV Deletion 19546169
esv2384607 CNV Deletion 18987734
dgv1149e201 CNV Deletion 23290073
esv3807 CNV Deletion 18987735
esv8642 CNV Loss 19470904
nsv366332 CNV Loss 16902084
esv2734743 CNV Deletion 23290073
nsv464609 CNV Loss 19166990

Relevant External Links for HGF Gene

HapMap Linkage Disequilibrium report
HGF
Human Gene Mutation Database (HGMD)
HGF

Disorders for HGF Gene

(1) OMIM Diseases for HGF Gene (142409)

UniProtKB/Swiss-Prot

HGF_HUMAN
  • Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:19576567}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for HGF Gene

(97) Novoseek inferred disease relationships for HGF Gene

Disease -log(P) Hits PubMed IDs
arteriosclerosis retinal 68.5 4
tumors 65.5 237
metastasis 62.2 128
hepatocellular carcinoma 60.3 97
renal fibrosis 59.8 23

Relevant External Links for HGF

Genetic Association Database (GAD)
HGF
Human Genome Epidemiology (HuGE) Navigator
HGF
genes like me logo Genes that share disorders with HGF: view

Publications for HGF Gene

  1. The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. (PMID: 9493272) Zhou H. … Byrd R.A. (Structure 1998) 3 4 23
  2. Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution. (PMID: 9817840) Ultsch M. … de Vos A.M. (Structure 1998) 3 4 23
  3. Assignment of the hepatocyte growth factor (HGF) to chromosome 7q22-qter. (PMID: 1837206) Laguda B. … Spurr N.K. (Ann. Hum. Genet. 1991) 2 3 23
  4. Evidence for the identity of human scatter factor and human hepatocyte growth factor. (PMID: 1831266) Weidner K.M. … Birchmeier W. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  5. Organization of the human hepatocyte growth factor-encoding gene. (PMID: 1831432) Seki T. … Shimizu S. (Gene 1991) 3 4 23

Products for HGF Gene

  • Addgene plasmids for HGF

Sources for HGF Gene

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