Aliases for HGF Gene
External Ids for HGF Gene
Previous HGNC Symbols for HGF Gene
Previous GeneCards Identifiers for HGF Gene
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for HGF Gene
HGF (Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)) is a Protein Coding gene. Diseases associated with HGF include deafness, autosomal recessive 39 and intracranial hemorrhage in brain cerebrovascular malformations. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include identical protein binding and growth factor activity. An important paralog of this gene is PLAT.
UniProtKB/Swiss-Prot for HGF Gene
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it can trigger tumor growth, angiogenesis and metastasis.