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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HGF Gene

protein-coding   GIFtS: 73
GCID: GC07M081328

Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)

(Previous names: deafness, autosomal recessive 39)
(Previous symbol: DFNB39)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)1 2     F-TCF2
DFNB391 2 5     HGFB2
Scatter Factor1 3     Hepatocyte Growth Factor2
Fibroblast-Derived Tumor Cytotoxic Factor1 2     hepatopoeitin-A2
Lung Fibroblast-Derived Mitogen1 2     hepatopoietin-A2
HPTA2 3     Hepatopoietin-A3
SF2 3     EC 3.4.218
Deafness, Autosomal Recessive 391     EC 3.4.21.78
Hepatopoietin A1     

External Ids:    HGNC: 48931   Entrez Gene: 30822   Ensembl: ENSG000000199917   OMIM: 1424095   UniProtKB: P142103   

Export aliases for HGF gene to outside databases

Previous GC identifers: GC07M079863 GC07M080926 GC07M080940 GC07M080943 GC07M080976 GC07M081166 GC07M075935


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HGF Gene:
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase
signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by
mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to
stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis,
and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into
a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the
active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no
detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for HGF Gene: 
HGF (hepatocyte growth factor (hepapoietin A; scatter factor)) is a protein-coding gene. Diseases associated with HGF include dfnb39 nonsyndromic hearing loss and deafness, and deafness, autosomal recessive 39, and among its related super-pathways are Development HGF signaling pathway and Integrin-mediated cell adhesion. GO annotations related to this gene include growth factor activity and protein heterodimerization activity. An important paralog of this gene is PLG.

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210
Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as
a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine
kinase MET by binding to it and promoting its dimerization

summary for HGF Gene:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for HGF (Hepatocyte growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HGF gene promoter:
         AP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HGF promoter sequence
   Search SABiosciences Chromatin IP Primers for HGF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.1

HGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HGF gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M081328:  view genomic region     (about GC identifiers)

Start:
81,328,322 bp from pter      End:
81,399,754 bp from pter
Size:
71,433 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 80,663,506-80,731,238     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210 (See protein sequence)
Recommended Name: Hepatocyte growth factor precursor  
Size: 728 amino acids; 83134 Da
Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond
Caution: Has lost two of the three essential catalytic residues and so probably has no enzymatic activity
6/14 PDB 3D structures from and Proteopedia for HGF (see all 14):
1BHT (3D)        1GMN (3D)        1GMO (3D)        1GP9 (3D)        1NK1 (3D)        1SHY (3D)    
Secondary accessions: A1L3U6 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6
Alternative splicing: 6 isoforms:  P14210-1   P14210-2   P14210-3   P14210-4   P14210-5   P14210-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HGF: NX_P14210

Explore proteomics data for HGF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14210

  • 2 DME Specific Peptides for HGF (P14210)
     NYCRNPD  PWCFTTDP 

    HGF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HGF Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_000592.3  NP_001010931.1  NP_001010932.1  NP_001010933.1  NP_001010934.1  

    ENSEMBL proteins: 
     ENSP00000222390   ENSP00000391238   ENSP00000389854   ENSP00000408270   ENSP00000413829  
     ENSP00000395468   ENSP00000396307   ENSP00000388592   ENSP00000346164  
    Reactome Protein details: P14210
    Human Recombinant Protein Products for HGF: 
    EMD Millipore Purified and/or Recombinant HGF Protein
    R&D Systems Recombinant & Natural Proteins for HGF
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    Novus Biologicals HGF Proteins
    Novus Biologicals HGF Lysates
    Sino Biological Recombinant Protein for HGF
    Sino Biological Cell Lysate for HGF 
    ProSpec Recombinant Protein for HGF
    Cloud-Clone Corp. Proteins for HGF 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0031093platelet alpha granule lumen TAS--

    HGF for ontologies           About GeneDecksing



    HGF Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HGF 

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    R&D Systems Flow Cytometry Kits for HGF         (see all)
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HGF 
    Cloud-Clone Corp. CLIAs for HGF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR001314 Peptidase_S1A
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR024174 HGF_MST1
     IPR027284 Hepatocyte_GF

    Graphical View of Domain Structure for InterPro Entry P14210

    ProtoNet protein and cluster: P14210

    5 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB003014 N/apple PAN
    IPB003609 Apple-like


    UniProtKB/Swiss-Prot: HGF_HUMAN, P14210
    Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily
    Similarity: Contains 4 kringle domains
    Similarity: Contains 1 PAN domain
    Similarity: Contains 1 peptidase S1 domain


    HGF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HGF_HUMAN, P14210
    Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as
    a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine
    kinase MET by binding to it and promoting its dimerization

         Genatlas biochemistry entry for HGF:
    hepatocyte growth factor,precursor of chains alpha and beta,expressed in
    platelets,fibroblast,macrophage,endothelial and smooth muscle cells

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.72

         Summary:
    During embryonic development, HGF as signaling molecule is secreted from the following cells: Progress Zone Cells in Limb Bud, Septum Transversum Mesenchyme Cells in Septum Transversum (see all 3).

    It affects the following cells: Hepatoblasts in Liver Bud, Hepatoblasts in Liver Bud (see all 7).

    HGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Hepatocyte-like cells from Liver, Immature hepatocyte-like cells from Liver (see all).

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252NOT serine-type endopeptidase activity NAS2531289
    GO:0005515protein binding IPI12694198
    GO:0008083growth factor activity NAS2531289
    GO:0042056chemoattractant activity IDA--
         
    HGF for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hgf):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     liver/biliary system  mortality/aging  no phenotypic analysis 

    HGF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HGF: Hgftm1Kita Hgftm1Cbm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HGF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HGF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HGF 

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate HGF (see all 12):
    hsa-miR-200a hsa-miR-888* hsa-miR-1297 hsa-miR-146a* hsa-miR-141 hsa-miR-374a* hsa-miR-141* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidHGF 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 5): HGF (NM_000601)
    Sino Biological Human cDNA Clone for HGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGF
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HGF About   (see all 35)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Renal cell carcinoma0.30
    2Focal Adhesion
    Focal Adhesion0.64
    HGF Pathway0.34
    Focal adhesion0.64
    3PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for HGF
        Development HGF signaling pathway
    Cell adhesion PLAU signaling

    5/64 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HGF (see all 64)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for HGF
        Cell adhesion PLAU signaling
    Development HGF signaling pathway

    5/10 BioSystems Pathways for HGF (see all 10)
        Focal Adhesion
    Prostate Cancer
    Arf6 signaling events
    Syndecan-1-mediated signaling events
    Stabilization and expansion of the E-cadherin adherens junction


    5/8        Reactome Pathways for HGF (see all 8)
        Hemostasis
    Interleukin-7 signaling
    Cytokine Signaling in Immune system
    Platelet degranulation
    Signaling by Interleukins


    5/8         Kegg Pathways  (Kegg details for HGF) (see all 8):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Focal adhesion
    Malaria
    Pathways in cancer


    HGF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for HGF (P142101, 2, 3 ENSP000002223904) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METP085811, 3, ENSP000003172724EBI-1039104,EBI-1039152 I2D: score=4 STRING: ENSP00000317272
    FN1P027513, ENSP000003468394I2D: score=1 STRING: ENSP00000346839
    HPNP059813, ENSP000002626264I2D: score=1 STRING: ENSP00000262626
    KLKB1P039523, ENSP000002646904I2D: score=1 STRING: ENSP00000264690
    LCN2P801883, ENSP000002774804I2D: score=1 STRING: ENSP00000277480
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0000902cell morphogenesis ----
    GO:0001837epithelial to mesenchymal transition TAS14679171
    GO:0001889liver development IEA--
    GO:0002576platelet degranulation TAS--

    HGF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HGF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HGF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    2 DrugBank Compounds for HGF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N,O6-Disulfo-Glucosamine-- --target--17139284 17016423
    O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423

    10/144 Novoseek inferred chemical compound relationships for HGF gene (see all 144)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 77.7 432 8601419 (4), 10644987 (4), 7475949 (4), 10521801 (3) (see all 99)
    vegf 77.7 523 18664639 (8), 11289497 (8), 16728464 (6), 17234170 (6) (see all 99)
    matrigel 68 43 15333517 (2), 9624561 (2), 15042617 (2), 10496342 (2) (see all 30)
    ly294002 57.3 11 12611639 (3), 17594810 (2), 18262389 (1), 17055484 (1) (see all 6)
    phosphatidylinositol 56.5 21 10763917 (2), 10362361 (1), 10739674 (1), 12531429 (1) (see all 18)
    pd 98,059 51.4 13 11057428 (2), 10362361 (1), 14598883 (1), 15672871 (1) (see all 12)
    wortmannin 50.8 12 10362361 (1), 15781227 (1), 18579758 (1), 15452053 (1) (see all 9)
    anit 49.1 12 9548396 (2), 1427661 (2), 19040928 (1), 1446596 (1)
    serine 46.9 86 17372204 (3), 15172968 (3), 20015050 (2), 11164712 (2) (see all 54)
    heparin 44.4 156 9254627 (8), 8288571 (7), 8262149 (6), 8138538 (6) (see all 49)

    Search CenterWatch for drugs/clinical trials and news about HGF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HGF gene (5 alternative transcripts): 
    NM_000601.4  NM_001010931.1  NM_001010932.1  NM_001010933.1  NM_001010934.1  

    Unigene Cluster for HGF:

    Hepatocyte growth factor (hepapoietin A; scatter factor)
    Hs.396530  [show with all ESTs]
    Unigene Representative Sequence: AK291674
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222390(uc003uhl.3 uc003uhm.3) ENST00000457544 ENST00000444829(uc003uhn.1 uc003uho.1)
    ENST00000453411 ENST00000423064(uc003uhp.3) ENST00000465234 ENST00000453018
    ENST00000412881 ENST00000421558 ENST00000354224(uc022agw.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    SwitchGear 3'UTR luciferase reporter plasmidHGF 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGF
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    Additional mRNA sequence: 

    AB208900.1 AK291674.1 AK313694.1 BC022308.1 BC063485.1 BC105797.1 BC130284.1 BC130286.1 
    FJ830861.1 FJ830862.1 L02931.1 M29145.1 M55379.1 M60718.1 M73239.1 M73240.1 
    M77227.1 U46010.1 X57574.1 

    7 DOTS entries:

    DT.314366  DT.75162211  DT.86846785  DT.40223084  DT.100709074  DT.100738092  DT.121113589 

    24/85 AceView cDNA sequences (see all 85):

    BU625850 M29145 CR600867 CR593759 M73239 BE326846 CN483847 AJ713089 
    M60718 BG572225 BM691444 NM_000601 L02931 AL546558 M55379 AI206848 
    AW276331 AL702032 BX956804 BC022308 M77227 BX497292 AL546883 BC063485 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HGF    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                              -                           
    SP2:                                -                                                         
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for HGF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HGF expression in normal human tissues (normalized intensities)      HGF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCCTTA
    HGF Expression
    About this image


    HGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Pons
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Progress Zone Cells Limb Bud
             Bone marrow-derived mesenchymal stem cells
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Sinusoidal Endothelial Cells Sinusoids
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Sinusoidal Endothelial Cells Sinusoids
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...

    See HGF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HGF

    SOURCE GeneReport for Unigene cluster: Hs.396530
        SABiosciences Expression via Pathway-Focused PCR Arrays including HGF (see all 12): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              Angiogenic Growth Factors in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HGF gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hgf1 , 5 hepatocyte growth factor1, 5 88.51(n)1
    91.03(a)1
      5 (7.07 cM)5
    152341  NM_010427.41  NP_034557.31 
     165535505 
    chicken
    (Gallus gallus)
    Aves HGF1 hepatocyte growth factor (hepapoietin A; scatter factor) 76.87(n)
    75.48(a)
      395941  NM_001030370.2  NP_001025541.2 
    lizard
    (Anolis carolinensis)
    Reptilia HGF6
    Uncharacterized protein
    66(a)
    1 ↔ 1
    5(92481221-92542103)
    zebrafish
    (Danio rerio)
    Actinopterygii hgfa1 hepatocyte growth factor a 55.09(n)
    49.55(a)
      493781  NM_001013274.1  NP_001013292.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mas6
    masquerade
    4(a)
    1 → many
    3L(4161666-4167464)


    ENSEMBL Gene Tree for HGF (if available)
    TreeFam Gene Tree for HGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HGF gene
    PLG2  PLAT2  HGFAC2  HABP22  LPA2  PLAU2  MST12  F122  
    7 SIMAP similar genes for HGF using alignment to 6 protein entries:     HGF_HUMAN (see all proteins):
    PLAT    F2    APOA    MST1    PLG    KLK9
    MST1L

    HGF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1376 SNPs in HGF are shown (see all 1376)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106542141,2
    C--75981727(+) CCTCTAAAAC/
            
    aaaac
    4 -- int11Minor allele frequency- -:0.50NA 2
    rs105394681,2
    C--80675368(+) tgtgcGT/-gtgtg 2 -- int11Minor allele frequency- -:0.50NA 2
    rs747928381,2
    --80700672(+) TTAAAA/CCCCAG 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1997389281,2
    C--80705406(+) CATGA-/TTTTTTTT 4 -- int10--------
    rs573490401,2
    C--80731933(+) TTTTT-/T/TT  
            
    CACAA
    5 -- us2k11NA 2
    rs57457691,2
    C,F--81331370(-) CACACTT/-TTTAC 2 -- ds50011Minor allele frequency- -:0.07NS 180
    rs3721262651,2
    C--81332555(+) TAAAG-/TTTTTT 2 -- int10--------
    rs598761481,2
    C--81335187(+) TTCTT-/AAAAAA 2 -- int10--------
    rs114323591,2
    C--81342853(+) AAAAAA/-TTTGT 2 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs606983271,2
    C--81344020(+) AAAAA-/AGAATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for HGF (81328322 - 81399754 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HGF:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv3807CNV Deletion18987735
    esv2384607CNV Deletion18987734
    esv2618632CNV Deletion19546169
    dgv1149e201CNV Deletion23290073
    esv2734743CNV Deletion23290073
    nsv366332CNV Loss16902084
    nsv464609CNV Loss19166990
    esv8642CNV Loss19470904
    nsv888562CNV Loss21882294


    Human Gene Mutation Database (HGMD): HGF
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HGF
    DNA2.0 Custom Variant and Variant Library Synthesis for HGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142409   
    OMIM disorders: 608265  
    UniProtKB/Swiss-Prot: HGF_HUMAN, P14210
  • Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural
    hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve
    pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20/217 diseases for HGF (see all 217):    About MalaCards
    dfnb39 nonsyndromic hearing loss and deafness    deafness, autosomal recessive 39    sos1-related noonan syndrome    arteriosclerosis
    salivary gland cancer    fulminant viral hepatitis    cascade stomach    gingival fibromatosis, 1
    alcoholic hepatitis    arteriosclerosis obliterans    coronary arteriosclerosis    proliferative diabetic retinopathy
    critical limb ischemia    gastroenteritis    short bowel syndrome    large cell medulloblastoma
    nodular goiter    acute liver failure    chronic leukemia    spinal cord ischemia

    2 diseases from the University of Copenhagen DISEASES database for HGF:
    Malignant glioma     Carcinoma

    HGF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/97 Novoseek inferred disease relationships for HGF gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arteriosclerosis retinal 68.5 7 9721534 (1), 9350587 (1), 10404823 (1), 9311255 (1)
    tumors 65.5 773 10810432 (6), 16945480 (6), 7853418 (6), 9788258 (5) (see all 99)
    metastasis 62.2 234 15492787 (4), 14598883 (3), 11118060 (3), 15221009 (3) (see all 99)
    hepatocellular carcinoma 60.3 123 11211911 (6), 11264569 (5), 8778194 (4), 15359093 (4) (see all 63)
    renal fibrosis 59.8 28 14638904 (4), 15180923 (3), 11593360 (3), 16838037 (1) (see all 16)
    hepatic failure fulminant 59.1 38 19624764 (3), 2142004 (2), 9286233 (2), 1827762 (2) (see all 26)
    cancer 55.4 308 15607934 (5), 11477552 (4), 11328532 (3), 12536083 (3) (see all 99)
    liver diseases 50.2 57 10220746 (4), 1833258 (3), 7806142 (2), 10594807 (2) (see all 35)
    arteriosclerosis obliterans 50.1 8 10373220 (2), 10429451 (1), 15238569 (1), 19225945 (1)
    neovascularization 49.3 24 12414523 (2), 8780385 (1), 10408347 (1), 17179234 (1) (see all 17)

    Genetic Association Database (GAD): HGF
    Human Genome Epidemiology (HuGE) Navigator: HGF (1257 documents)

    Export disorders for HGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HGF gene, integrated from 9 sources (see all 2211):
    (articles sorted by number of sources associating them with HGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. (PubMed id 19576567)1, 2, 3 Schultz J.M.... Morell R.J. (2009)
    2. Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia. (PubMed id 16723436)1, 4, 9 Han W....Yip S.P. (2006)
    3. The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. (PubMed id 9493272)1, 2, 9 Zhou H.... Byrd R.A. (1998)
    4. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. (PubMed id 15167892)1, 2, 9 Stamos J....Wiesmann C. (2004)
    5. Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. (PubMed id 15064106)1, 4, 9 Takiuchi S....Tomoike H. (2004)
    6. Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution. (PubMed id 9817840)1, 2, 9 Ultsch M.... de Vos A.M. (1998)
    7. Organization of the human hepatocyte growth factor-encoding gene. (PubMed id 1831432)1, 2, 9 Seki T.... Shimizu S. (1991)
    8. Assignment of the hepatocyte growth factor (HGF) to chromosome 7q22-qter. (PubMed id 1837206)1, 3, 9 Laguda B....Spurr N.K. (1991)
    9. Evidence for the identity of human scatter factor and human hepatocyte growth factor. (PubMed id 1831266)1, 2, 9 Weidner K.M....Birchmeier W. (1991)
    10. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3082 HGNC: 4893 AceView: HGF Ensembl:ENSG00000019991 euGenes: HUgn3082
    ECgene: HGF Kegg: 3082 H-InvDB: HGF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HGF Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hgf/
    Wikipedia http://en.wikipedia.org/wiki/Hepatocyte_growth_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HGF gene:
    Search GeneIP for patents involving HGF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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