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HGF Gene

protein-coding GIFtS: 71

GC07M081166

hepatocyte growth factor (hepapoietin A; scatter factor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
F-TCF ^¹, ²
HGFB ^¹, ²
HPTA ^¹, ², ³
Hepatopoeitin-A ^³
SF ^¹, ², ³

Descriptions
Scatter factor ^², ³
fibroblast-derived tumor cytotoxic factor ^²
hepatocyte growth factor ^²
hepatocyte growth factor (hepapoietin A; scatter factor) ^²
hepatopoietin A ^²
lung fibroblast-derived mitogen ^²

External Ids
HGNC: 4893¹
Entrez Gene: 3082²
UniProtKB: P14210³
Ensembl: ENSG00000019991⁷

Search outside databases for aliases for HGF gene

Previous GC identifers: GC07M079863 GC07M080926 GC07M080940 GC07M080943 GC07M080976

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HGF:

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a

tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte

growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of

mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion

gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as

a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and

34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active,

heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has

no detectable protease activity. Alternative splicing of this gene produces multiple transcript

variants encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210

Function: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an

hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It

has no detectable protease activity

Gene Wiki entry for HGF (Hepatocyte_growth_factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HGF gene

Entrez Gene cytogenetic band: 7q21.1 Ensembl cytogenetic band: 7q21.11 HGNC cytogenetic band: 7q21.1

HGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M081166: (about GC identifiers)

Start:	81,169,274 bp from pter
End:	81,237,388 bp from pter
Size:	68,115 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 80,663,506-80,731,238

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HGF_HUMAN, P14210 (See protein sequence)

Recommended Name: Hepatocyte growth factor precursor

Size: 728 amino acids; 83134 Da

Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond

PDB structures from and Proteopedia :

1BHT (3D)

1GMN (3D)

1GMO (3D)

1GP9 (3D)

1NK1 (3D)

1SHY (3D)

1SI5 (3D)

2HGF (3D)

2QJ2 (3D)

Secondary accessions: A1L3U6 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6

Alternative splicing: 6 isoforms: P14210-1 P14210-2 P14210-3 P14210-4 P14210-5 P14210-6

REFSEQ proteins (5 alternative transcripts):

NP_000592.3 NP_001010931.1 NP_001010932.1 NP_001010933.1 NP_001010934.1

ENSEMBL proteins:

ENSP00000378250 ENSP00000346164 ENSP00000222390

Human Recombinant Proteins

	Invitrogen human recombinant proteins for HGF
	Millipore Purified and/or Recombinant HGF Protein
	Sigma-Aldrich Proteins for HGF
	R&D Systems Recombinant & Natural Proteins for HGF
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HGF)
	Human Recombinant Proteins from Abnova (HGF)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	EXP	2531289
GO:0031093	platelet alpha granule lumen	EXP	2531289

About this table

Antibodies for HGF:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HGF
	R&D Systems Antibodies for HGF
	Antibodies from Abcam (HGF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HGF)
	Novus Biologicals Antibodies for HGF

Assays for HGF:

	Invitrogen Assays for HGF
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for HGF (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P14210

ProtoNet protein and cluster: P14210

5 Blocks protein families:

IPB000001 Kringle

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB003014 N/apple PAN

IPB003609 Apple-like

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210

Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily

Similarity: Contains 4 kringle domains

Similarity: Contains 1 PAN domain

Similarity: Contains 1 peptidase S1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HGF)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HGF)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_000601

Applied Biosystems Silencer® siRNAs for HGF

Sigma-Aldrich siRNA and siRNA Panels for HGF

Sigma-Aldrich shRNA Panels and shRNA for HGF

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HGF
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000601
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000601
untagged cDNA clones in CMV expression vector (see all 5): NM_000601

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000601

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210

Function: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an

hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It

has no detectable protease activity

Genatlas biochemistry entry for HGF:

hepatocyte growth factor,precursor of chains alpha and beta,expressed in

platelets,fibroblast,macrophage,endothelial and smooth muscle cells

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hgf):

	embryogenesis	growth/size	hematopoietic system	lethality-prenatal/perinatal
liver/biliary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	IEA	--
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	15167892 18585357
GO:0008083	growth factor activity	NAS	2531289

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for HGF (Your Favorite Gene powered by Ingenuity)

HGF Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation
FGF Signaling
Renal Cell Carcinoma Signaling
Macropinocytosis

GeneDecks HGF for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HGF

5/125 Interacting proteins for HGF (ENSP00000222390³ P14210^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 125 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MET	P08581¹	STRING (score=.999) EBI-1039104, EBI-1039152
Met Met (xeno)	P16056¹	EBI-1039104, EBI-1798780
FLT1	ENSP00000282397³	STRING (score=.989)
GRB2	ENSP00000339007³	STRING (score=.989)
GLMN	ENSP00000359385³	STRING (score=.983)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IEA	--
GO:0000902	cell morphogenesis	IEA	--
GO:0001837	epithelial to mesenchymal transition	TAS	14679171
GO:0001889	liver development	IEA	--
GO:0006508	proteolysis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for HGF available from Tocris Bioscience

Compound	Action	CAS number
PHA 665752	Potent and selective MET inhibitor	[477575-56-7]
K 252a	Protein kinase inhibitor	[99533-80-9]

About this table

10/43 Novoseek chemical compound relationships for HGF gene (see all 43 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	77.13	398	8601419 (4), 10644987 (4), 7475949 (4), 10521801 (3) (see all 99)
matrigel	68.98	43	15333517 (2), 9624561 (2), 15042617 (2), 10496342 (2) (see all 30)
phosphatidylinositol	55.14	20	10763917 (2), 10362361 (1), 10739674 (1), 12531429 (1) (see all 17)
pd 98,059	53.31	13	11057428 (2), 10362361 (1), 14598883 (1), 15672871 (1) (see all 12)
wortmannin	50.42	12	10362361 (1), 15781227 (1), 18579758 (1), 15452053 (1) (see all 9)
tgf beta1	46.18	20	15646350 (3), 15580170 (2), 10222131 (2), 17626784 (2) (see all 11)
hepaplastin	44.43	1	8680544 (1)
heparan sulfate	44.21	38	11435444 (5), 9428228 (2), 8157651 (2), 9777710 (1) (see all 15)
anit	41.83	12	9548396 (2), 1427661 (2), 19040928 (1), 1446596 (1)
dimethylnitrosamine	39.96	21	18637143 (5), 9548396 (3), 9214455 (2), 9708531 (2) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HGF)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HGF)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_000601

Sigma-Aldrich siRNA and siRNA Panels for HGF

Sigma-Aldrich shRNA Panels and shRNA for HGF

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000601 NM_001010931 NM_001010932 NM_001010933 NM_001010934

REFSEQ mRNAs for HGF gene (5 alternative transcripts):

NM_000601.4 NM_001010931.1 NM_001010932.1 NM_001010933.1 NM_001010934.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000601 NM_001010931 NM_001010932 NM_001010933 NM_001010934

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000601
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000601
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_000601

Additional cDNA sequence:

AB208900.1 AK291674.1 AK313694.1 BC022308.1 BC063485.1 BC105797.1 BC130284.1 BC130286.1

CR593759.1 CR600867.1 L02931.1 M29145.1 M55379.1 M60718.1 M73239.1 M73240.1

M77227.1 U46010.1 X57574.1

6 DOTS entries:

DT.314366 DT.75162211 DT.86846785 DT.100709074 DT.100738092 DT.121113589

24/85 AceView cDNA sequences (see all 85 ):

BU625850 CR600867 AJ713089 M55379 NM_000601 M73239 AL546558 M60718

AI206848 M29145 BM691444 BG572225 L02931 CN483847 CR593759 BE326846

BX497292 M77227 M73240 BU753481 BC022308 AA037738 CB961241 BX497293

highest scoring ESTs for HGF:

M73239 AA037738 AL702032 AV759905 BC022308 BE244598 BG622782 BI915528 BU533235 BX503837

Unigene Cluster for HGF:

Hepatocyte growth factor (hepapoietin A; scatter factor)

Hs.396530 [show with all ESTs]

Unigene Representative Sequence: AK291674

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HGF

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:																					-
SP2:											-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for HGF

3 Ensembl transcripts including schematic representations:

ENST00000394769 ENST00000354224 ENST00000222390

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HGF expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HGF

¹ / ² / ³

12 probe-sets matching HGF gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1095_s_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.98	M73239	1.00	1.00	1.00	1
1340_s_at²^{, 3}	U95-A	1	1.00	1.00	0.77	1.38	X16323	0.80	1.00	0.91	1
210997_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M77227	0.80	1.00	0.91	1
210998_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M77227	0.80	1.00	0.91	1
210755_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U46010	0.80	1.00	0.91	1
209961_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M60718	0.80	1.00	0.91	1
209960_at²^{, 3}	U133-A	1	0.73	1.00	--	--	X16323	0.80	1.00	0.91	1
210997_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210998_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210755_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209961_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209960_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGGCCCTTA

SOURCE GeneReport for Unigene cluster: Hs.396530
Expression variation in blood from EXPOLDB for HGF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HGF gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HGF¹	--	hepatocyte growth factor (hepapoietin A; scatter factor)	92.49(n) 92.72(a)	403441 NM_001002964.1 NP_001002964.1
chimpanzee (Pan troglodytes)	HGF¹	--	hepatocyte growth factor (hepapoietin A; scatter factor)	99.91(n) 99.86(a)	463503 XM_519174.2 XP_519174.2
cow (Bos taurus)	HGF¹	--	hepatocyte growth factor (hepapoietin A; scatter factor)	92.76(n) 93.4(a)	282879 NM_001031751.1 NP_001026921.1
rat (Rattus norvegicus)	Hgf¹	--	hepatocyte growth factor	88.09(n) 90.62(a)	24446 NM_017017.1 NP_058713.1
mouse (Mus musculus)	Hgf^{1, 5}	5 (4.00 cM)⁵	hepatocyte growth factor^{1, 5}	88.32(n)¹ 90.76(a)¹	15234¹ NM_010427.2¹ NP_034557.2¹ AF042856⁵ AK033274⁵ (see all 19)

About this table Species with no ortholog for HGF

ENSEMBL Gene Tree for HGF

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HGF gene

KREMEN1² LPA² KREMEN2² MST1² MSTP9² PLG²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/422 NCBI SNPs in HGF are shown (see all 422 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 196)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2214825^1,2	A,C,F,H,O	81209555(+)	`CATAGC/TGTGGA`	4	--	int¹ ng5¹		13	NA EU EA WA	1160
	rs11763015^1,2	A,C,F,H	81239365(+)	`cataaG/Tacccc`	5	--	ng3¹		4	EU EA WA	420
	rs3735520^1,2	A,C,F,H	81238875(-)	`AGATCC/TCTCAA`	5	--	ng3¹		9	EA EU WA NA	2113
	rs5745676^1,2	A,C,F,H	81210092(-)	`AATCTC/TTATAG`	4	--	ut3¹ int¹ ese³		12	NS NA EU EA WA	1150
	rs5745687^1,2	C,F,H	81196987(-)	`CAACTG/AAATGC`	2	K/E	mis¹ ese³		10	NS EU EA WA NA	1059
	rs5745653^1,2	C,F,H	81218510(-)	`AAATTA/GTTAGG`	5	--	int¹ ut3¹		5	NS EU EA WA	590
	rs5745646^1,2	C,F,H	81219262(-)	`TGTTCA/GTGCAA`	5	--	ut3¹ int¹		5	NS EU EA WA	600
	rs5745678^1,2	A,C,F	81209983(-)	`TTACCC/TAGCTT`	4	--	ut3¹ int¹ ese³		8	NS NA EA	674
	rs5745608^1,2	C,F,H	81237441(-)	`AAAGGA/CGGGGG`	5	--	ng3¹ trp³		5	NS EU EA WA	544
	rs5745677^1,2	F,H	81210015(-)	`GTCCAT/CACAAT`	4	--	int¹ ut3¹ ese³		5	NS EU EA WA	590

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HapMap Linkage Disequilibrium images for HGF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 142409

10/96 Novoseek disease relationships for HGF gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
arteriosclerosis retinal	69.31	7	9721534 (1), 9350587 (1), 10404823 (1), 9311255 (1)
tumors	64.53	717	10810432 (6), 16945480 (6), 7853418 (6), 9788258 (5) (see all 99)
hepatocellular carcinoma	61.41	119	11211911 (6), 11264569 (5), 8778194 (4), 15359093 (4) (see all 61)
metastasis	60.98	215	15492787 (4), 14598883 (3), 11118060 (3), 15221009 (3) (see all 99)
renal fibrosis	60.39	27	14638904 (4), 15180923 (3), 11593360 (3), 16838037 (1) (see all 15)
hepatic failure fulminant	59.97	34	2142004 (2), 9286233 (2), 10385651 (2), 1827762 (2) (see all 25)
cancer	53.36	278	15607934 (5), 11477552 (4), 11328532 (3), 12631221 (3) (see all 99)
arteriosclerosis obliterans	51.70	8	10373220 (2), 10429451 (1), 15238569 (1), 19225945 (1)
liver diseases	49.82	55	10220746 (4), 1833258 (3), 7806142 (2), 10594807 (2) (see all 33)
proliferative diabetic retinopathy	48.76	26	10600653 (2), 16029908 (2), 11148602 (2), 9773744 (2) (see all 14)

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Human Gene Mutation Database: HGF
Genetic Association Database: HGF
Human Genome Epidemiology Navigator: HGF (891 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1840 PubMed articles for HGF gene (see all 1840 ):

Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. (PubMed id 15064106)^{1, 3, 6} Takiuchi S....Tomoike H. (2004)
Assignment of the hepatocyte growth factor (HGF) to chromosome 7q22-qter. (PubMed id 1837206)^{1, 2, 3} Laguda B....Spurr N.K. (1991)
Evidence for the identity of human scatter factor and human hepatocyte growth factor. (PubMed id 1831266)^{1, 3, 4} Weidner K.M....Birchmeier W. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association between hepatocyte growth factor gene polymorphism and essential hypertension. (PubMed id 15127882)^{3, 6} Motone M....Ogihara T. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{3, 4} Scherer S.W....Tsui L.C. (2003)
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)^{3, 6} Watanabe I....Koga T. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution. (PubMed id 9817840)^{3, 4} Ultsch M.... de Vos A.M. (1998)
The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. (PubMed id 9493272)^{3, 4} Zhou H.... Byrd R.A. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3082	HGNC: 4893	AceView: HGF	Ensembl:ENSG00000019991	euGenes: HUgn3082
ECgene: HGF	H-InvDB: HGF

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for HGF	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hgf/
Wikipedia	http://en.wikipedia.org/wiki/Hepatocyte_growth_factor

Licensable Technologies for HGF
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HGF:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HGF-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Predesigned and custom siRNAs for HGF		Antibodies for HGF
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Antibodies for HGF

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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HGF Gene at Home site.
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HGF Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for HGF

Summaries
for HGF

Genomic Location
for HGF

Proteins
for HGF

Protein Domains/
Families
for HGF

Gene Function
for HGF

Pathways & Interactions
for HGF

Drugs & Compounds
for HGF

Transcripts
for HGF

Expression
for HGF

Orthologs
for HGF

Paralogs
for HGF

SNPs/Variants
for HGF

Disorders & Mutations
for HGF

Medical News
for HGF

Publications
for HGF

Search for HGF

Genome Databases showing HGF

Other Databases showing HGF

Specialized Databases showing HGF

Licensable Technologies
for HGF

Services
for HGF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HGF Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor HGF

Summariesfor HGF

Genomic Locationfor HGF

Proteinsfor HGF

Protein Domains/Familiesfor HGF

Gene Functionfor HGF

Pathways & Interactionsfor HGF

Drugs & Compoundsfor HGF

Transcriptsfor HGF

Expression for HGF

Orthologsfor HGF

Paralogsfor HGF

SNPs/Variantsfor HGF

Disorders & Mutationsfor HGF

Medical Newsfor HGF

Publicationsfor HGF

Search for HGF

Genome Databases showing HGF

Other Databases showing HGF

Specialized Databases showing HGF

Licensable Technologiesfor HGF

Servicesfor HGF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HGF

Summaries
for HGF

Genomic Location
for HGF

Proteins
for HGF

Protein Domains/
Families
for HGF

Gene Function
for HGF

Pathways & Interactions
for HGF

Drugs & Compounds
for HGF

Transcripts
for HGF

Expression
for HGF

Orthologs
for HGF

Paralogs
for HGF

SNPs/Variants
for HGF

Disorders & Mutations
for HGF

Medical News
for HGF

Publications
for HGF

Licensable Technologies
for HGF

Services
for HGF