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HGF Gene

protein-coding   GIFtS: 73
GCID: GC07M081328

Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)

(Previous names: deafness, autosomal recessive 39)
(Previous symbol: DFNB39)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)1 2     F-TCF2
DFNB391 2 5     HGFB2
Scatter Factor1 3     Hepatocyte Growth Factor2
Fibroblast-Derived Tumor Cytotoxic Factor1 2     hepatopoeitin-A2
Lung Fibroblast-Derived Mitogen1 2     hepatopoietin-A2
HPTA2 3     Hepatopoietin-A3
SF2 3     EC 3.4.218
Deafness, Autosomal Recessive 391     EC 3.4.21.78
Hepatopoietin A1     

External Ids:    HGNC: 48931   Entrez Gene: 30822   Ensembl: ENSG000000199917   OMIM: 1424095   UniProtKB: P142103   

Export aliases for HGF gene to outside databases

Previous GC identifers: GC07M079863 GC07M080926 GC07M080940 GC07M080943 GC07M080976 GC07M081166 GC07M075935


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HGF Gene:
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase
signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by
mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to
stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis,
and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into
a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the
active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no
detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for HGF Gene:
HGF (hepatocyte growth factor (hepapoietin A; scatter factor)) is a protein-coding gene. Diseases associated with HGF include crohn disease-associated growth failure, and dfnb39 nonsyndromic hearing loss and deafness. GO annotations related to this gene include growth factor activity and identical protein binding. An important paralog of this gene is PLG.

UniProtKB/Swiss-Prot: HGF_HUMAN, P14210
Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as
a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine
kinase MET by binding to it and promoting its dimerization

summary for HGF Gene:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for HGF (Hepatocyte growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HGF gene promoter:
         AP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HGF promoter sequence
   Search Chromatin IP Primers for HGF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.1

HGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HGF gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M081328:  view genomic region     (about GC identifiers)

Start:
81,328,322 bp from pter      End:
81,399,754 bp from pter
Size:
71,433 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 80,663,506-80,731,238     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HGF_HUMAN, P14210 (See protein sequence)
Recommended Name: Hepatocyte growth factor precursor  
Size: 728 amino acids; 83134 Da
Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the
interaction increases HGF mitogenic activity
Caution: Has lost two of the three essential catalytic residues and so probably has no enzymatic activity
Selected PDB 3D structures from and Proteopedia for HGF (see all 15):
1BHT (3D)        1GMN (3D)        1GMO (3D)        1GP9 (3D)        1NK1 (3D)        1SHY (3D)    
Secondary accessions: A1L3U6 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6
Alternative splicing: 6 isoforms:  P14210-1   P14210-2   P14210-3   P14210-4   P14210-5   P14210-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HGF: NX_P14210

Explore proteomics data for HGF at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn294, Asn402, Thr476, Asn566, Asn653
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for HGF (P14210)
     NYCRNPD  PWCFTTDP 


    See HGF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000592.3  NP_001010931.1  NP_001010932.1  NP_001010933.1  NP_001010934.1  

    ENSEMBL proteins: 
     ENSP00000222390   ENSP00000391238   ENSP00000389854   ENSP00000408270   ENSP00000413829  
     ENSP00000395468   ENSP00000396307   ENSP00000388592   ENSP00000346164  
    Reactome Protein details: P14210

    HGF Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HGF
    OriGene MassSpec for HGF
    OriGene Custom Protein Services for HGF
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    Novus Biologicals HGF Proteins
    Novus Biologicals HGF Lysates
    Sino Biological Recombinant Protein for HGF
    Sino Biological Cell Lysate for HGF
    ProSpec Recombinant Protein for HGF
    Cloud-Clone Corp. Proteins for HGF

    HGF Antibody Products:

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    Abcam antibodies for HGF
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    ThermoFisher Antibody for HGF
    LSBio Antibodies in human, mouse, rat for HGF

    HGF Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Flow Cytometry Kits for HGF         (see all)
    GenScript Custom Assay Services for HGF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HGF
    Cloud-Clone Corp. CLIAs for HGF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR001314 Peptidase_S1A
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR024174 HGF_MST1
     IPR027284 Hepatocyte_GF

    Graphical View of Domain Structure for InterPro Entry P14210

    ProtoNet protein and cluster: P14210

    5 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB003014 N/apple PAN
    IPB003609 Apple-like


    UniProtKB/Swiss-Prot: HGF_HUMAN, P14210
    Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily
    Similarity: Contains 4 kringle domains
    Similarity: Contains 1 PAN domain
    Similarity: Contains 1 peptidase S1 domain


    HGF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HGF_HUMAN, P14210
    Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as
    a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine
    kinase MET by binding to it and promoting its dimerization

         Genatlas biochemistry entry for HGF:
    hepatocyte growth factor,precursor of chains alpha and beta,expressed in
    platelets,fibroblast,macrophage,endothelial and smooth muscle cells

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.72

         Summary: 
    During embryonic development, HGF as signaling molecule is secreted from the following cells:
          selected tissues (see all 3)      
    Liver: Sinusoidal Endothelial Cells (Sinusoids)
    Limb: Progress Zone Cells (Limb Bud)

    It affects the following cells:
          selected tissues (see all 4)      fully expand
    Liver: Hepatoblasts (Liver Bud), Hepatocytes (Liver Bud)      fully expand to see all 2 cells
    Limb: Limb Muscle Progenitor Cells (Forelimb Myotome), Limb Muscle Progenitor Cells (Hindlimb Myotome)      fully expand to see all 2 cells

    HGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 4)      fully expand
    Liver: Immature hepatocytes, Hepatocyte-like cells      fully expand to see all 3 cells
    Kidney: Epithelial Podocyte-like cells, Epithelial Podocyte-like cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252NOT serine-type endopeptidase activity NAS2531289
    GO:0005515protein binding IPI12694198
    GO:0008083growth factor activity NAS2531289
    GO:0042056chemoattractant activity IDA--
         
    HGF for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hgf):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     liver/biliary system  mortality/aging  no phenotypic analysis 

    HGF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HGF: Hgftm1Kita Hgftm1Cbm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HGF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HGF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HGF

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HGF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HGF (see all 12):
    hsa-miR-200a hsa-miR-888* hsa-miR-1297 hsa-miR-146a* hsa-miR-141 hsa-miR-374a* hsa-miR-141* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidHGF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HGF
    Predesigned siRNA for gene silencing in human, mouse, rat HGF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HGF

    Clone
    Products:
         
    OriGene clones in human, mouse for HGF (see all 26)
    OriGene ORF clones in mouse, rat for HGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): HGF (NM_000601)
    Sino Biological Human cDNA Clone for HGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGF

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HGF
    Browse ESI BIO Cell Lines and PureStem Progenitors for HGF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0031093platelet alpha granule lumen TAS--

    HGF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HGF About   (see all 36)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    3Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Signaling of Hepatocyte Growth Factor Receptor0.35
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HGF (see all 64)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for HGF
        Cell adhesion PLAU signaling
    Development HGF signaling pathway

    Selected BioSystems Pathways for HGF (see all 10)
        Focal Adhesion
    Prostate Cancer
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    Direct p53 effectors
    Arf6 signaling events


    2 Reactome Pathways for HGF
        Interleukin-7 signaling
    Platelet degranulation


    Selected Kegg Pathways  (Kegg details for HGF) (see all 10):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Focal adhesion


    HGF for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HGF (see all 12): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HGF (P142101, 2, 3 ENSP000002223904) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METP085811, 3, ENSP000003172724EBI-1039104,EBI-1039152 I2D: score=4 STRING: ENSP00000317272
    FN1P027513, ENSP000003468394I2D: score=1 STRING: ENSP00000346839
    HPNP059813, ENSP000002626264I2D: score=1 STRING: ENSP00000262626
    KLKB1P039523, ENSP000002646904I2D: score=1 STRING: ENSP00000264690
    LCN2P801883, ENSP000002774804I2D: score=1 STRING: ENSP00000277480
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0000902cell morphogenesis ----
    GO:0001837epithelial to mesenchymal transition TAS14679171
    GO:0001889liver development IEA--
    GO:0002576platelet degranulation TAS--

    HGF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HGF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    2 DrugBank Compounds for HGF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N,O6-Disulfo-Glucosamine-- --target--17139284 17016423
    O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for HGF gene (see all 144)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 77.7 432 8601419 (4), 10644987 (4), 7475949 (4), 10521801 (3) (see all 99)
    vegf 77.7 523 18664639 (8), 11289497 (8), 16728464 (6), 17234170 (6) (see all 99)
    matrigel 68 43 15333517 (2), 9624561 (2), 15042617 (2), 10496342 (2) (see all 30)
    ly294002 57.3 11 12611639 (3), 17594810 (2), 18262389 (1), 17055484 (1) (see all 6)
    phosphatidylinositol 56.5 21 10763917 (2), 10362361 (1), 10739674 (1), 12531429 (1) (see all 18)
    pd 98,059 51.4 13 11057428 (2), 10362361 (1), 14598883 (1), 15672871 (1) (see all 12)
    wortmannin 50.8 12 10362361 (1), 15781227 (1), 18579758 (1), 15452053 (1) (see all 9)
    anit 49.1 12 9548396 (2), 1427661 (2), 19040928 (1), 1446596 (1)
    serine 46.9 86 17372204 (3), 15172968 (3), 20015050 (2), 11164712 (2) (see all 54)
    heparin 44.4 156 9254627 (8), 8288571 (7), 8262149 (6), 8138538 (6) (see all 49)



    HGF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HGF gene (5 alternative transcripts): 
    NM_000601.4  NM_001010931.1  NM_001010932.1  NM_001010933.1  NM_001010934.1  

    Unigene Cluster for HGF:

    Hepatocyte growth factor (hepapoietin A; scatter factor)
    Hs.396530  [show with all ESTs]
    Unigene Representative Sequence: AK291674
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222390(uc003uhl.3 uc003uhm.3) ENST00000457544 ENST00000444829(uc003uhn.1 uc003uho.1)
    ENST00000453411 ENST00000423064(uc003uhp.3) ENST00000465234 ENST00000453018
    ENST00000412881 ENST00000421558 ENST00000354224(uc022agw.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat HGF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HGF (see all 12):
    hsa-miR-200a hsa-miR-888* hsa-miR-1297 hsa-miR-146a* hsa-miR-141 hsa-miR-374a* hsa-miR-141* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidHGF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HGF
    Clone
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    OriGene clones in human, mouse for HGF (see all 26)
    OriGene ORF clones in mouse, rat for HGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): HGF (NM_000601)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGF
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HGF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HGF
      QuantiTect SYBR Green Assays in human, mouse, rat HGF
      QuantiFast Probe-based Assays in human, mouse, rat HGF

    Additional mRNA sequence: 

    AB208900.1 AK291674.1 AK313694.1 BC022308.1 BC063485.1 BC105797.1 BC130284.1 BC130286.1 
    FJ830861.1 FJ830862.1 L02931.1 M29145.1 M55379.1 M60718.1 M73239.1 M73240.1 
    M77227.1 U46010.1 X57574.1 

    7 DOTS entries:

    DT.314366  DT.75162211  DT.86846785  DT.40223084  DT.100709074  DT.100738092  DT.121113589 

    Selected AceView cDNA sequences (see all 85):

    CR593759 L02931 M29145 CR600867 CN483847 M60718 M55379 BM691444 
    BU625850 BE326846 AJ713089 AI206848 AL546558 BG572225 M73239 NM_000601 
    BX497292 AA687773 BC022308 AL702032 AL546825 BM971901 AL546883 AL571866 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HGF    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                              -                           
    SP2:                                -                                                         
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for HGF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HGF expression in normal human tissues (normalized intensities)      HGF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCCTTA
    HGF Expression
    About this image


    HGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Progress Zone Cells Limb Bud
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Mesothelial Cells Hepatic Mesenchyme
             Hepatocyte-like cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Limb (Muscoskeletal System)
             Progress Zone Cells Limb Bud
    HGF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HGF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.396530
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HGF (see all 12): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              Angiogenic Growth Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for HGF gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hgf1 , 5 hepatocyte growth factor1, 5 88.51(n)1
    91.03(a)1
      5 (7.07 cM)5
    152341  NM_010427.41  NP_034557.31 
     165535505 
    chicken
    (Gallus gallus)
    Aves HGF1 hepatocyte growth factor (hepapoietin A; scatter factor) 76.87(n)
    75.35(a)
      395941  NM_001030370.2  NP_001025541.2 
    lizard
    (Anolis carolinensis)
    Reptilia HGF6
    hepatocyte growth factor (hepapoietin A; scatter f...
    67(a)
    1 ↔ 1
    5(92481221-92542103)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hgf1 hepatocyte growth factor (hepapoietin A; scatter factor) 70.63(n)
    68.77(a)
      100495840  XM_002933096.2  XP_002933142.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hgfa1 hepatocyte growth factor a 55.29(n)
    49.55(a)
      493781  NM_001013274.1  NP_001013292.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tequila6
    Tequila
    5(a)
    1 → many
    3L(9067745-9085231)
    worm
    (Caenorhabditis elegans)
    Secernentea svh-16
    Protein SVH-1 (svh-1) mRNA, complete cds
    13(a)
    1 → many
    IV(8206614-8213723) WBGene00006620


    ENSEMBL Gene Tree for HGF (if available)
    TreeFam Gene Tree for HGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HGF gene
    PLG2  PLAT2  HGFAC2  HABP22  LPA2  PLAU2  MST12  F122  
    7 SIMAP similar genes for HGF using alignment to 6 protein entries:     HGF_HUMAN (see all proteins):
    PLAT    F2    APOA    MST1    PLG    KLK9
    MST1L

    HGF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HGF (see all 1376)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106542141,2
    C--75981727(+) CCTCTAAAAC/
            
    aaaac
    4 -- int11Minor allele frequency- -:0.50NA 2
    rs105394681,2
    C--80675368(+) tgtgcGT/-gtgtg 2 -- int11Minor allele frequency- -:0.50NA 2
    rs747928381,2
    --80700672(+) TTAAAA/CCCCAG 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1997389281,2
    C--80705406(+) CATGA-/TTTTTTTT 4 -- int10--------
    rs573490401,2
    C--80731933(+) TTTTT-/T/TT  
            
    CACAA
    5 -- us2k11NA 2
    rs57457691,2
    C,F--81331370(-) CACACTT/-TTTAC 2 -- ds50011Minor allele frequency- -:0.07NS 180
    rs3721262651,2
    C--81332555(+) TAAAG-/TTTTTT 2 -- int10--------
    rs598761481,2
    C--81335187(+) TTCTT-/AAAAAA 2 -- int10--------
    rs114323591,2
    C--81342853(+) AAAAAA/-TTTGT 2 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs606983271,2
    C--81344020(+) AAAAA-/AGAATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for HGF (81328322 - 81399754 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HGF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3807CNV Deletion18987735
    esv2384607CNV Deletion18987734
    esv2618632CNV Deletion19546169
    dgv1149e201CNV Deletion23290073
    esv2734743CNV Deletion23290073
    nsv366332CNV Loss16902084
    nsv464609CNV Loss19166990
    esv8642CNV Loss19470904
    nsv888562CNV Loss21882294

    Human Gene Mutation Database (HGMD): HGF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HGF
    DNA2.0 Custom Variant and Variant Library Synthesis for HGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142409   
    OMIM disorders: 608265  
    UniProtKB/Swiss-Prot: HGF_HUMAN, P14210
  • Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural
    hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve
    pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for HGF (see all 231):    About MalaCards
    crohn disease-associated growth failure    dfnb39 nonsyndromic hearing loss and deafness    deafness, autosomal recessive 39    intracranial hemorrhage in brain cerebrovascular malformations
    diabetes mellitus    arteriosclerosis    kaposi's sarcoma    fulminant viral hepatitis
    gingival fibromatosis, 1    fibromatosis, gingival    salivary gland cancer    cascade stomach
    noonan syndrome 4    sos1-related noonan syndrome    proliferative diabetic retinopathy    juvenile rheumatoid arthritis
    coronary arteriosclerosis    arteriosclerosis obliterans    alcoholic hepatitis    gastroenteritis

    2 diseases from the University of Copenhagen DISEASES database for HGF:
    Malignant glioma     Carcinoma

    HGF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for HGF gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arteriosclerosis retinal 68.5 7 9721534 (1), 9350587 (1), 10404823 (1), 9311255 (1)
    tumors 65.5 773 10810432 (6), 16945480 (6), 7853418 (6), 9788258 (5) (see all 99)
    metastasis 62.2 234 15492787 (4), 14598883 (3), 11118060 (3), 15221009 (3) (see all 99)
    hepatocellular carcinoma 60.3 123 11211911 (6), 11264569 (5), 8778194 (4), 15359093 (4) (see all 63)
    renal fibrosis 59.8 28 14638904 (4), 15180923 (3), 11593360 (3), 16838037 (1) (see all 16)
    hepatic failure fulminant 59.1 38 19624764 (3), 2142004 (2), 9286233 (2), 1827762 (2) (see all 26)
    cancer 55.4 308 15607934 (5), 11477552 (4), 11328532 (3), 12536083 (3) (see all 99)
    liver diseases 50.2 57 10220746 (4), 1833258 (3), 7806142 (2), 10594807 (2) (see all 35)
    arteriosclerosis obliterans 50.1 8 10373220 (2), 10429451 (1), 15238569 (1), 19225945 (1)
    neovascularization 49.3 24 12414523 (2), 8780385 (1), 10408347 (1), 17179234 (1) (see all 17)

    Genetic Association Database (GAD): HGF
    Human Genome Epidemiology (HuGE) Navigator: HGF (1257 documents)

    Export disorders for HGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HGF gene, integrated from 10 sources (see all 2230):
    (articles sorted by number of sources associating them with HGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. (PubMed id 19576567)1, 2, 3 Schultz J.M.... Morell R.J. (Am. J. Hum. Genet. 2009)
    2. Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia. (PubMed id 16723436)1, 4, 9 Han W....Yip S.P. (amp 2006)
    3. The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. (PubMed id 9493272)1, 2, 9 Zhou H.... Byrd R.A. (Structure 1998)
    4. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. (PubMed id 15167892)1, 2, 9 Stamos J.... Wiesmann C. (EMBO J. 2004)
    5. Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. (PubMed id 15064106)1, 4, 9 Takiuchi S....Tomoike H. (Atherosclerosis 2004)
    6. Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution. (PubMed id 9817840)1, 2, 9 Ultsch M.... de Vos A.M. (Structure 1998)
    7. Organization of the human hepatocyte growth factor-encoding gene. (PubMed id 1831432)1, 2, 9 Seki T.... Shimizu S. (Gene 1991)
    8. Assignment of the hepatocyte growth factor (HGF) to chromosome 7q22-qter. (PubMed id 1837206)1, 3, 9 Laguda B....Spurr N.K. (Ann. Hum. Genet. 1991)
    9. Evidence for the identity of human scatter factor and human hepatocyte growth factor. (PubMed id 1831266)1, 2, 9 Weidner K.M....Birchmeier W. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3082 HGNC: 4893 AceView: HGF Ensembl:ENSG00000019991 euGenes: HUgn3082
    ECgene: HGF Kegg: 3082 H-InvDB: HGF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HGF Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hgf/
    Wikipedia http://en.wikipedia.org/wiki/Hepatocyte_growth_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HGF gene:
    Search GeneIP for patents involving HGF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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