HGD Gene
protein-coding GIFtS: 63
GCID: GC03M120347
|
|
homogentisate 1,2-dioxygenase(Previous name: homogentisate 1,2-dioxygenase (homogentisate oxidase) )
(Previous symbol: AKU)
| |
Aliases
for HGD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Homogentisate 1,2-Dioxygenase1 2 | | EC 1.13.11.53 8 | | HGO1 2 3 | | Homogentisate 1,2-Dioxygenase (Homogentisate Oxidase)1 | | AKU1 2 5 | | Homogentisate Oxidase2 | | Homogentisate Oxygenase2 3 | | Homogentisicase3 | | Homogentisic Acid Oxidase2 3 | | Homogentisicase3 |
Export aliases for HGD gene to outside databasesPrevious GC identifers: GC03M116980 GC03M119987 GC03M121628 GC03M121667 GC03M121829 GC03P9I0013 GC03M117720 |
Summaries
for HGD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HGD:
This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the aminoacids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorderalkaptonuria.(provided by RefSeq, May 2010)
|
Genomic Views
for HGD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HGD gene promoter:
HFH-3 HSF1 (long) LUN-1 CUTL1 FOXI1 PPAR-gamma1 POU2F1 POU2F1a HSF1short PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HGD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HGD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.33 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3qHGD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M120347: view genomic region
(about GC identifiers)
Start:
|
120,347,015 bp from pter |
End:
|
120,401,418 bp from pter |
Size:
|
54,404 bases |
Orientation:
|
minus strand |
|
Proteins
for HGD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HGD_HUMAN, Q93099 (See
protein sequence)Recommended Name: Homogentisate 1,2-dioxygenase Size: 445 amino acids; 49964 Da
Cofactor: Iron
2 PDB 3D structures from  and Proteopedia  for HGD:1EY2 (3D)
1EYB (3D)
Secondary accessions: B2R8Z0Explore the universe of human proteins at neXtProt for HGD: NX_Q93099
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q93099
4/11 DME Specific Peptides for HGD (Q93099) (see all 11)
HGD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000178.2
ENSEMBL proteins: ENSP00000283871 ENSP00000419838 ENSP00000417977 ENSP00000419163 ENSP00000419560 Reactome Protein details: Q93099
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
HGD for ontologies About GeneDecksing
HGD Antibody Products:
Assay Products for HGD: |
Protein
Domains /
Families
for HGD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HGD for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q93099ProtoNet protein and cluster: Q93099 1 Blocks protein family: IPB005708 Homogentisate 1,2-dioxygenase
UniProtKB/Swiss-Prot: HGD_HUMAN, Q93099Similarity: Belongs to the homogentisate dioxygenase family |
Function
for HGD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HGD_HUMAN, Q93099Catalytic activity: Homogentisate + O(2) = 4-maleylacetoacetate Genatlas biochemistry entry for HGD:homogentisate 1,2 dioxygenase (49kDa),catalyzing the third step of tyrosine catabolism
Enzyme Number (IUBMB): EC 1.13.11.51 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HGD (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HGD (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): HGD (NM_004309) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HGD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGD |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004411 | homogentisate 1,2-dioxygenase activity |
EXP | -- | | GO:0046872 | metal ion binding |
IEA | -- |
HGD for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HGD:
Animal Models:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hgd):
HGD for phenotypes About GeneDecksing
|
Pathways & Interactions
for HGD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | tyrosine degradation I | | | 2 | Metabolism | | | 3 | Metabolism of amino acids and derivatives | | | 4 | Tyrosine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for HGD
3 
Reactome Pathways for HGD
2 
Kegg Pathways (Kegg details for HGD):
UniProtKB/Swiss-Prot: HGD_HUMAN, Q93099Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6
HGD for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HGD
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for HGD (Q930992, 3 ENSP000002838714) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006520 | cellular amino acid metabolic process |
-- | -- | | GO:0006559 | L-phenylalanine catabolic process |
TAS | -- | | GO:0006570 | tyrosine metabolic process |
-- | -- | | GO:0006572 | tyrosine catabolic process |
IEA | -- | | GO:0034641 | cellular nitrogen compound metabolic process |
TAS | -- |
HGD for ontologies About GeneDecksing
|
Drugs & Compounds
for HGD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HGD for compounds About GeneDecksing
 Browse Tocris compounds for HGD
4 HMDB Compounds for HGD About this table
4 Novoseek chemical compound relationships for HGD gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| homogentisate |
97.8 |
28 |
10205262 (2), 9244427 (2), 9069115 (1), 10876237 (1) (see all 22) |
| maleylacetoacetate |
81.7 |
3 |
15479158 (1), 14678794 (1) |
| phenylalanine |
62 |
5 |
12872815 (1), 10985185 (1), 19306858 (1), 11001939 (1) |
| tyrosine |
46.7 |
9 |
12872815 (1), 10461246 (1), 15479158 (1), 14678794 (1) (see all 8) |
Search CenterWatch for drugs/clinical trials and news about HGD
|
Transcripts
for HGD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HGD gene: NM_000187.3 Unigene Cluster for HGD: Homogentisate 1,2-dioxygenase Hs.368254 [show with all ESTs]Unigene Representative Sequence: NM_00018710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283871(uc003edv.3 uc003edw.3) ENST00000492108 ENST00000470321
ENST00000475447 ENST00000494453 ENST00000476082 ENST00000485313 ENST00000488183
ENST00000466528 ENST00000480862
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HGD (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HGD (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): HGD (NM_004309) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HGD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGD |
Additional cDNA sequence: AF045167.1 AK290782.1 AK313563.1 BC020792.1 BC071757.1 U63008.1 Z75048.1 13 DOTS entries: DT.448199 DT.75102164 DT.120896549 DT.40114075 DT.97841083 DT.95134736 DT.120896535 DT.65285493 DT.87015021 DT.100664585 DT.120896538 DT.40114076 DT.40246141 24/140 AceView cDNA sequences (see all 140): AW270892 BM818532 BI759927 AF045167 AI984644 BG432599 BM765698 BM829875 BM830006 BF589896 AK124291 BM772112 BQ184523 BX101754 AW237456 U63008 BC071757 BM006163 BU190419 BG490699 BI761581 BX495082 BG568456 Z75048
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HGD (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HGD
|
Expression
for HGD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HGD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCTGGTA
About this image
See HGD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HGD
SOURCE GeneReport for Unigene cluster: Hs.368254
UniProtKB/Swiss-Prot: HGD_HUMAN, Q93099Tissue specificity: Highest expression in the prostate, small intestine, colon, kidney and liver
SABiosciences Expression via Pathway-Focused PCR Array including HGD:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HGD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HGD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HGD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HGD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGD |
Orthologs
for HGD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HGD gene from 9/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Hgd1 , 5 |
homogentisate 1, 2-dioxygenase1, 5 |
88.44(n)1
92.79(a)1 |
|
16 (26.40 cM)5
152331 NM_013547.31 NP_038575.21
375801535 |
chicken
(Gallus gallus) |
Aves |
HGD1 |
homogentisate 1,2-dioxygenase |
76.92(n)
83.6(a) |
|
418330 XM_416553.1 XP_416553.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HGD6 |
-- |
74(a) |
1 ↔ 1 |
GL343473.1(635209-650903) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.88152 |
Transcribed sequence with moderate similarity to protein more |
78.1(n) |
|
CF150913.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hgd2 |
homogentisate 1,2-dioxygenase |
76.45(n) |
|
259189 BC064283.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
hgo1 , 3 |
phenylalanine catabolism homogentisate
1,2-dioxygenase3
homogentisate 1,2-dioxygenase1 |
65(a)3
65.59(n)1
67.44(a)1 |
|
32D53
345521 NM_078820.21 NP_523544.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
hgo-11 |
Protein HGO-1 |
61.75(n)
66.98(a) |
|
172726 NM_060032.5 NP_492433.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HGO1 |
homogentisate 1,2-dioxygenase |
60.34(n)
60.19(a) |
|
835494 NM_124787.3 NP_200219.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.116222 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.4(n) |
|
AK062144.1 |
ENSEMBL Gene Tree for HGD (if available)
TreeFam Gene Tree for HGD (if available) |
Paralogs
for HGD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HGD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HGD (120347015 - 120401418 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HGD: --
Human Gene Mutation Database (HGMD): HGD
Locus Specific Mutation Databases (LSDB): HGD
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HGD |
|
Disorders
/ Diseases
for HGD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HGD for disorders About GeneDecksing
OMIM gene information: 607474
OMIM disorders: 203500
UniProtKB/Swiss-Prot: HGD_HUMAN, Q93099
Defects in HGD are the cause of alkaptonuria (AKU) [MIM:203500]. AKU is an autosomal recessive error ofmetabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU areurine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenoustissues, and spine arthritis
12  diseases for HGD: About MalaCardsalkaptonuria metabolic disorders ochronosis aortic valve stenosis
alcaptonuria arthropathy hepatitis b arthritis
osteoarthritis hepatitis prostatitis lumbar disc herniation
4 diseases from the University of Copenhagen DISEASES database for HGD:Alkaptonuria Alcaptonuria Ochronosis Carcinoma 7 Novoseek disease relationships for HGD gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alkaptonuria |
98.7 |
46 |
9069115 (2), 10205262 (2), 12630963 (2), 19306858 (2) (see all 36) |
| ochronosis |
97.7 |
13 |
9214216 (1), 10461246 (1), 16371803 (1), 10340975 (1) (see all 13) |
| metabolic disorder |
67.9 |
8 |
19293619 (1), 16311673 (1), 8782815 (1), 16736091 (1) (see all 8) |
| arthropathy |
67.7 |
3 |
19293619 (1), 16085442 (1), 15529343 (1) |
| arthritis |
54.9 |
1 |
15931605 (1) |
| aortic stenosis |
53.7 |
1 |
10461246 (1) |
| genetic disorder |
38.1 |
2 |
10985185 (1), 20229718 (1) |
GeneTests: HGD
Alkaptonuria
Human Genome Epidemiology (HuGE) Navigator: HGD (3 documents)
Export disorders for HGD gene to outside databases
|
Publications
for HGD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HGD gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with HGD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Analysis of alkaptonuria (AKU) mutations and polymorphisms reveals that the CCC sequence motif is a mutational hot spot in the homogentisate 1,2 dioxygenase gene (HGO). (PubMed id 10205262)1, 2, 9 Beltran-Valero de Bernabe D....Rodriguez de Cordoba S. (1999)
- The human homogentisate 1,2-dioxygenase (HGO) gene. (PubMed id 9244427)1, 2, 9 Granadino B.... Rodriguez de Cordoba S. (1997)
- Crystal structure of human homogentisate dioxygenase. (PubMed id 10876237)1, 2, 9 Titus G.P.... Timm D.E. (2000)
- Ocular ochronosis in alkaptonuria patients carrying mutations in the homogentisate 1,2-dioxygenase gene. (PubMed id 10340975)1, 2, 9 Felbor U.... Kress W. (1999)
- Mutation and polymorphism analysis of the human homogentisate 1, 2- dioxygenase gene in alkaptonuria patients. (PubMed id 9529363)1, 2, 9 Beltran-Valero de Bernabe D.... de Cordoba S.R. (1998)
- Mutational analysis of the HGO gene in Finnish alkaptonuria patients. (PubMed id 10594001)1, 2, 9 Beltran-Valero de Bernabe D.... Ranki A. (1999)
- The molecular basis of alkaptonuria. (PubMed id 8782815)1, 2, 9 Fernandez-Canon J.M.... Rodriguez de Cordoba S. (1996)
- Allelic heterogeneity of alkaptonuria in Central Europe. (PubMed id 10482952)1, 2, 9 Mueller C.R.... Kress W. (1999)
- Molecular defects in alkaptonuria. (PubMed id 9154114)1, 2, 9 Gehrig A.... Kress W. (1997)
- The human gene for alkaptonuria (AKU) maps to chromosome 3q. (PubMed id 8188241)1, 3, 9 Janocha S....Muller C.R. (1994)
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External Searches for HGD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HGD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing HGD gene
(According to HUGE)
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Specialized Databases showing HGD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HGD | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HGD |
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About This Section
| Patent Information for HGD gene:
Search GeneIP for patents involving HGD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HGD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for HGD | | OriGene shRNA RFP for HGD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HGD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HGD | | | OriGene Protein Over-expression Lysate for HGD | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HGD | | OriGene 3'-UTR Clone for HGD | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HGD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HGD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HGD | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HGD | | OriGene Custom Protein Services for HGD | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HGD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HGD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HGD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HGD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HGD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HGD |
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| | | | Search Tocris compounds for HGD |
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 | | | HGD Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HGD |
|  |  |  | | | | Search ThermoFisher Antibodies for HGD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HGD |
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