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HFM1 Gene

protein-coding   GIFtS: 54
GCID: GC01M091726

HFM1, ATP-Dependent DNA Helicase Homolog (S. Cerevisiae)

(Previous name: SEC63 domain containing 1)
(Previous symbol: SEC63D1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
HFM1, ATP-Dependent DNA Helicase Homolog (S. Cerevisiae)1 2     helicase2
SEC63D11 2     Helicase-Like Protein HFM12
SEC63 Domain Containing 11 2     Probable ATP-Dependent DNA Helicase HFM12
SEC63 Domain-Containing Protein 12 3     EC 3.6.4.123
MER32 5     SEC3D13
Si-112     POF95
Si-11-62     EC 3.6.18

External Ids:    HGNC: 201931   Entrez Gene: 1640452   Ensembl: ENSG000001626697   OMIM: 6156845   UniProtKB: A2PYH43   
ORGUL members:         

Export aliases for HFM1 gene to outside databases

Previous GC identifers: GC01M091556 GC01M091499 GC01M089845


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HFM1 Gene:
HFM1 (HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with HFM1 include spastic hemiplegia, and epicondylitis. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HFM1 gene promoter:
         Nkx3-1 v4   Sox5   Brachyury   FOXD3   HNF-3beta   MEF-2A   IRF-7A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHFM1 promoter sequence
   Search Chromatin IP Primers for HFM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HFM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.2   Ensembl cytogenetic band:  1p22.2   HGNC cytogenetic band: 1p22.2

HFM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HFM1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M091726:  view genomic region     (about GC identifiers)

Start:
91,726,323 bp from pter      End:
91,870,426 bp from pter
Size:
144,104 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HFM1_HUMAN, A2PYH4 (See protein sequence)
Recommended Name: Probable ATP-dependent DNA helicase HFM1  
Size: 1435 amino acids; 162610 Da
Secondary accessions: B1B0B6 Q8N9Q0
Alternative splicing: 2 isoforms:  A2PYH4-1   A2PYH4-2   

Explore the universe of human proteins at neXtProt for HFM1: NX_A2PYH4

Explore proteomics data for HFM1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for HFM1 (A2PYH4)
     QMIGRAGR  APTGSGKT  GRAGRPQF 


    See HFM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001017975.3  
    ENSEMBL proteins: 
     ENSP00000359454   ENSP00000387661   ENSP00000397369   ENSP00000388900   ENSP00000409827  
     ENSP00000359453   ENSP00000294696  

    HFM1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HFM1

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    Cloud-Clone Corp. ELISAs for HFM1
    Cloud-Clone Corp. CLIAs for HFM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR004179 Sec63-dom
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry A2PYH4

    ProtoNet protein and cluster: A2PYH4

    UniProtKB/Swiss-Prot: HFM1_HUMAN, A2PYH4
    Similarity: Belongs to the helicase family. SKI2 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 SEC63 domain


    HFM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HFM1_HUMAN, A2PYH4
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003677DNA binding ----
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    HFM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HFM1:
     Decreased Wnt reporter activit 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hfm1):
     endocrine/exocrine gland  reproductive system 

    HFM1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HFM1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HFM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HFM1

    miRNA
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    miRTarBase miRNAs that target HFM1:
    hsa-mir-335-5p (MIRT017476), hsa-mir-124-3p (MIRT022487)

    Block miRNA regulation of human, mouse, rat HFM1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HFM1
    SwitchGear 3'UTR luciferase reporter plasmidHFM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HFM1

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    GenScript: all cDNA clones in your preferred vector: HFM1 (NM_006304)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HFM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HFM1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HFM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HFM1
    Interactions:

        Search GeneGlobe Interaction Network for HFM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HFM1 (A2PYH43 ENSP000003594544) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF2P136393, ENSP000003079404I2D: score=1 STRING: ENSP00000307940
    PPP2CBP627143, ENSP000002211384I2D: score=1 STRING: ENSP00000221138
    PLRG1O436603I2D: score=2 
    ENO3P139293I2D: score=1 
    EXOSC10Q017803I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000712resolution of meiotic recombination intermediates IEA--

    HFM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HFM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HFM1 gene: 
    NM_001017975.3  

    Unigene Cluster for HFM1:

    HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
    Hs.454818  [show with all ESTs]
    Unigene Representative Sequence: AB204867
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462405 ENST00000370425(uc009wdb.3 uc001doa.4 uc010osu.2)
    ENST00000430465(uc001dob.4) ENST00000497520 ENST00000481900(uc001doc.1)
    ENST00000488023 ENST00000448819 ENST00000427444 ENST00000455133 ENST00000370424
    ENST00000294696(uc010osv.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HFM1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HFM1
    SwitchGear 3'UTR luciferase reporter plasmidHFM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HFM1
    Predesigned siRNA for gene silencing in human, mouse, rat HFM1
    Clone
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    OriGene clones in human, mouse for HFM1 (see all 6)
    OriGene ORF clones in mouse, rat for HFM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HFM1 (NM_006304)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HFM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HFM1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HFM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HFM1
      QuantiTect SYBR Green Assays in human, mouse, rat HFM1
      QuantiFast Probe-based Assays in human, mouse, rat HFM1

    Additional mRNA sequence: 

    AB044787.1 AB044788.1 AB058636.1 AB058637.1 AB074274.1 AB204867.1 AK294754.1 AK302582.1 
    BC062793.1 BC130525.1 BC144172.1 BC144198.1 BX649037.1 

    8 DOTS entries:

    DT.105340  DT.97796872  DT.100730550  DT.121390752  DT.121390755  DT.121390757  DT.99930630  DT.102821192 

    2 AceView cDNA sequences:

    BX481571 AK096330 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HFM1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                                                    -         
    SP2:                                                                                                                              


    ECgene alternative splicing isoforms for HFM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HFM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTGTTT
    HFM1 Expression
    About this image


    HFM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)
     
     Larynx (Respiratory System)
    HFM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HFM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.454818
        Custom PCR Arrays for HFM1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HFM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HFM1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hfm11 , 5 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)1, 5 83.16(n)1
    77.15(a)1
      5 (51.43 cM)5
    3301491  NM_177873.31  NP_808541.21 
     1068401925 
    chicken
    (Gallus gallus)
    Aves HFM11 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 70.06(n)
    63.7(a)
      424509  XM_422349.4  XP_422349.3 
    lizard
    (Anolis carolinensis)
    Reptilia HFM16
    HFM1, ATP-dependent DNA helicase homolog (S. cerev...
    62(a)
    1 ↔ 1
    4(94594205-94653782)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hfm11 HFM1, ATP-dependent DNA helicase homolog 64.71(n)
    59.11(a)
      779837  NM_001078915.2  NP_001072383.3 
    zebrafish
    (Danio rerio)
    Actinopterygii hfm11 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 62.56(n)
    58.92(a)
      557052  XM_001919520.4  XP_001919555.4 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0090601 AgaP_AGAP009060 45(n)
    38.21(a)
      3291892  XM_552976.3  XP_552976.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HFM16
    Meiosis specific DNA helicase involved in the conv...
    28(a)
    1 ↔ 1
    VII(27921-31636) YGL251C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RCK1 RCK 50.79(n)
    43.03(a)
      822395  NM_113689.2  NP_189410.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g06175001 Os02g0617500 52.29(n)
    45.77(a)
      4329993  NM_001053977.1  NP_001047442.1 


    ENSEMBL Gene Tree for HFM1 (if available)
    TreeFam Gene Tree for HFM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HFM1 gene
    2 SIMAP similar genes for HFM1 using alignment to 8 protein entries:     HFM1_HUMAN (see all proteins):
    Si-11-6    Si-11

    HFM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HFM1 (see all 2935)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847694471,2
    --91725904(+) AACAAC/TAGACA 1 -- int10--------
    rs1456054561,2
    --91725912(+) ACACTA/GGGGCC 1 -- int10--------
    rs1156789211,2
    C,F--91726109(+) TTTCTA/GAAAGT 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1883676871,2
    --91726197(+) ACTTAA/TCAATA 1 -- int10--------
    rs1915301311,2
    --91726245(+) AATATA/CTTTTT 1 -- int10--------
    rs412867691,2
    C,F--91726288(+) GACAAC/GATTGA 1 -- int13Minor allele frequency- G:0.16NA WA 240
    rs1152850151,2
    C,F--91726448(+) CCATAC/TAATAA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1423633031,2
    --91726539(+) CATTGC/GTTCTT 1 -- ut310--------
    rs412867711,2
    --91726637(+) AACAAA/TGCCAC 1 -- ut310--------
    rs412867731,2
    C,F--91726679(+) AATGGG/AAAAAT 1 -- ut311Minor allele frequency- A:0.04NA 120

    HapMap Linkage Disequilibrium report for HFM1 (91726323 - 91870426 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HFM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714684CNV Deletion23290073
    nsv871685CNV Loss21882294
    nsv519110CNV Loss19592680
    nsv437904CNV Loss16468122
    esv5793CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HFM1
    DNA2.0 Custom Variant and Variant Library Synthesis for HFM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615684   
    OMIM disorders: 615724  
    9 diseases for HFM1:    
    About MalaCards
    spastic hemiplegia    epicondylitis    fukuyama congenital muscular dystrophy    hemiplegia
    congenital muscular dystrophy    muscular dystrophy    spasticity    tuberculosis
    malaria

    2 diseases from the University of Copenhagen DISEASES database for HFM1:
    Spastic hemiplegia     Epicondylitis

    HFM1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HFM1
    Human Genome Epidemiology (HuGE) Navigator: HFM1 (2 documents)

    Export disorders for HFM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HFM1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HFM1)
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    1. HFM1, the human homologue of yeast Mer3, encodes a putative DNA helicase expressed specifically in germ-line cells. (PubMed id 17286053)1, 2, 3, 9 Tanaka K.... Ikeda J.E. (DNA Seq. 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Mutations in HFM1 in recessive primary ovarian insufficiency. (PubMed id 24597873)1 Wang J....Wu B.L. (N. Engl. J. Med. 2014)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 164045 HGNC: 20193 AceView: LOC164045 Ensembl:ENSG00000162669 euGenes: HUgn164045
    ECgene: HFM1 H-InvDB: HFM1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HFM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HFM1 gene:
    Search GeneIP for patents involving HFM1

    GeneCards and IP:
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