HFE Gene

Aliases &
Descriptions
for HFE

Previous GC identifer: GC06P026130

Summaries
for HFE

Gene Wiki entry for HFE

Genomic Location
for HFE

Proteins
for HFE

PDB structures from and Proteopedia :

1A6Z (3D)    1C42 (3D)    1DE4 (3D)    

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	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HFE)
	Human Recombinant Proteins from Abnova (HFE)

4 Gene Ontology (GO) cellular component terms (links to tree view):

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	Sigma-Aldrich Antibodies for HFE
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (HFE), each with their AbpromiseSM
	Monoclonal and Polyclonal Antibodies from Abnova (HFE)
	Novus Biologicals Antibodies for HFE

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	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for HFE

5/6 InterPro domains/families (see all 6 ):

IPR007110 Ig-like  IPR003006 Ig/MHC_CS  IPR011161 MHC_I-like_Ag-recog  IPR001039 MHC_I_a_a1/a2  IPR013783 Ig-like_fold    GeneDecks  HFE for the domains selected above   About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q30201

ProtoNet protein and cluster: Q30201

Gene Function
for HFE

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HFE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HFE)

Clones:		Invitrogen Clones for HFE
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

11 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Hfe):

1 Gene Ontology (GO) molecular function term (links to tree view):

Pathways & Interactions
for HFE

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

Drugs & Compounds
for HFE

Transcripts
for HFE

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HFE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HFE)

Applied Biosystems Silencer® siRNAs: 

REFSEQ mRNAs for HFE gene (9 alternative transcripts): 

Applied Biosystems TaqMan ® Gene Expression Assays: 

Expression
for HFE

HFE expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for HFE

¹ / ² / ³

32 probe-sets matching HFE gene

	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
			# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	80609_at2, 3	U95-D	1	1.00	1.00	0.63	1.13	AI290427	0.60	1.00	0.82	1
	38913_at2, 3	U95-A	1	1.00	1.00	0.87	0.98	U60319	0.80	1.00	0.91	1
	50664_at2, 3	U95-B	1	0.81	1.00	0.61	0.91	T59431	0.20	1.00	0.72	1
	211332_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF144241	0.40	1.00	0.76	1
	214647_s_at2, 3	U133-A	1	1.00	1.00	--	--	BG402460	0.60	1.00	0.82	1
	211866_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF079409	0.60	1.00	0.82	1
	206086_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF115265	0.60	1.00	0.82	1
	211328_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF144244	0.40	1.00	0.76	1
	211329_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF115264	0.60	1.00	0.82	1
	211863_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF079408	0.60	1.00	0.82	1
	211326_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF150664	0.40	1.00	0.76	1
	211327_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF149804	0.60	1.00	0.82	1
	211330_s_at2, 3	U133-A	1	1.00	1.00	--	--	AF144242	0.60	1.00	0.82	1
	211331_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF144243	0.40	1.00	0.76	1
	206087_x_at2, 3	U133-A	16	1.00	0.92	--	--	NM_000410	0.60	1.00	0.82	1
	210864_x_at2, 3	U133-A	16	1.00	0.92	--	--	AF144240	0.60	1.00	0.82	1
	235754_at2	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
	211332_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	1553402_a_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	214647_s_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211866_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	206086_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211328_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211329_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211863_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211330_s_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211326_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211327_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211331_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	206087_x_at2	U133Plus2	16	1.00	0.92	--	--	--	--	--	--	--
	210864_x_at2	U133Plus2	16	1.00	0.92	--	--	--	--	--	--	--
	235754_at2	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.233325

Expression variation in blood from EXPOLDB for HFE

UniProtKB/Swiss-Prot: HFE_HUMAN, Q30201

Tissue specificity: In all tissues tested except brain

Orthologs
for HFE

Paralogs
for HFE

Paralogs for HFE gene

ENSG00000204520²  AZGP1P1²  FCGRT²  ENSG00000204516²  AZGP1P2²  

SNPs/Variants
for HFE

Disorders & Mutations
for HFE

UniProtKB/Swiss-Prot: HFE_HUMAN, Q30201

Medical News
for HFE

• Iron Overload Gene Tied To Increased Risk Of Colon Cancer
• New Test Measures Hepcidin, Can Help Diagnose Anaemias and Iron Disorders

Publications
for HFE

• Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy. (PubMed id 11423500)^{1, 3, 4, 6} Moczulski D.K....Gawlik B. (2001)
• Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. (PubMed id 10638746)^{1, 3, 4} Bennett M.J.... Bjorkman P.J. (2000)
• Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. (PubMed id 9546397)^{1, 3, 4} Lebron J.A.... Bjorkman P.J. (1998)
• The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein. (PubMed id 15965644)^{1, 3, 4} Ka C.... Ferec C. (2005)
• Hemochromatosis gene mutations and distal adenomatous colorectal polyps. (PubMed id 15668490)^{1, 3, 6} McGlynn K.A....Buetow K.H. (2005)
• [Association of mutations of HFE gene and hepatocellular carcinoma following chronic hepatitis B] (PubMed id 16174459)^{1, 3, 6} Shi W.J....Cheng J. (2005)
• [HFE gene mutations, hepatic iron content, and histological severity in hepatitis C virus-induced chronic hepatitis] (PubMed id 14972004)^{1, 3, 6} Ladero J.M....Diaz-Rubio M. (2003)
• Analysis of HFE and TFR2 mutations in selected blood donors with biochemical parameters of iron overload. (PubMed id 12681966)^{1, 3, 6} De Gobbi M....Camaschella C. (2003)
• A 3-dimensional model building by homology of the HFE protein: molecular consequences and application to antibody development. (PubMed id 11018711)^{1, 3, 4} Dupradeau F....Rochette J. (2000)
• Two novel missense mutations of the HFE gene (I105T and G93R) and identification of the S65C mutation in Alabama hemochromatosis probands. (PubMed id 10575540)^{1, 3, 4} Barton J.C.... Acton R.T. (1999)
• The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene. (PubMed id 9548560)^{1, 3, 4} Albig W.... Doenecke D. (1998)
• Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America. (PubMed id 9620340)^{1, 3, 4} Bonkovsky H.L....Lambrecht R.W. (1998)
• Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. (PubMed id 14752836)^{1, 3, 6} Bugianesi E....Rizzetto M. (2004)
• Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload. (PubMed id 14633868)^{1, 3, 4} Biasiotto G....Arosio P. (2003)
• A homozygous HFE gene splice site mutation (IVS5+1 G/A) in a hereditary hemochromatosis patient of Vietnamese origin. (PubMed id 11875012)^{1, 3, 6} Steiner M....Schmidt H. (2002)
• Analysis of HFE and TFR2 gene mutations in patients with acute leukemia. (PubMed id 15863206)^{1, 3, 6} Veneri D....Pizzolo G. (2005)
• HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. (PubMed id 14670915)^{1, 3, 6} Jacolot S.... Ferec C. (2004)
• Lack of association between HFE gene mutations and hepatocellular carcinoma in patients with cirrhosis. (PubMed id 12865278)^{1, 3, 6} Boige V....Buffet C. (2003)
• A search for association between hereditary hemochromatosis HFE gene mutations and type 2 diabetes mellitus in a Polish population. (PubMed id 12601293)^{1, 3, 6} Mal/ecki M.T....Sieradzki J. (2003)
• Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism. (PubMed id 12902032)^{1, 3, 6} Dekker M.C....van Duijn C.M. (2003)
• A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism. (PubMed id 12673276)^{1, 3, 6} Njajou O.T....van Duijn C.M. (2003)
• Idiopathic hemochromatosis with the mutation of Ala176Val heterozygous for HFE gene. (PubMed id 11446670)^{1, 3, 4} Imanishi H.... Hada T. (2001)
• A 6-year survey of HFE gene test for hemochromatosis diagnosis. (PubMed id 15654232)^{1, 3, 6} Mura C....Ferec C. (2005)
• [Mutations in the HFE gene in patients with rheumatic diseases] (PubMed id 16047841)^{1, 3, 6} Putova I....Horak J. (2005)
• Prevalence of HFE and TFR2 gene mutation in 118 Ligurian rheumatic patients. (PubMed id 15785438)^{1, 3, 6} Rovetta G....Franchin F. (2004)
• [Polymorphism of the HFE gene associated with hereditary hemochromatosis in populations of Russia] (PubMed id 12942784)^{1, 3, 6} Mikhailova S.V....Voevoda M.I. (2003)
• Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C. (PubMed id 12445428)^{1, 3, 6} Bonkovsky H.L....Hsieh C.C. (2002)
• [Importance of 5569G/A polymorphism in intron 4 of HFE gene in the diagnosis of hereditary hemochromatosis] (PubMed id 11730630)^{1, 3, 6} Roman R....Guix M. (2001)
• Spectrum of mutations in the HFE gene implicated in haemochromatosis and porphyria. (PubMed id 10401000)^{1, 3, 4} de Villiers J.N.P.... Kotze M.J. (1999)
• High prevalence of the His63Asp HFE mutation in Italian patients with porphyria cutanea tarda. (PubMed id 9425935)^{1, 3, 4} Sampietro M.... Fargion S. (1998)
• Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer. (PubMed id 15941956)^{3, 6} Robinson J.P....Silver A.R. (2005)
• Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease. (PubMed id 15060098)^{3, 6} Robson K.J....Smith A.D. (2004)
• Absence of hemochromatosis associated Cys282Tyr HFE gene mutation and low frequency of hemochromatosis phenotype in nonalcoholic chronic liver disease patients in India. (PubMed id 14675248)^{3, 6} Thakur V....Sarin S.K. (2004)
• Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands). (PubMed id 12948285)^{3, 6} van der A D.L....Peeters P.H. (2003)
• Haptoglobin type neither influences iron accumulation in normal subjects nor predicts clinical presentation in HFE C282Y haemochromatosis: phenotype and genotype analysis. (PubMed id 12846904)^{3, 6} Carter K....Worwood M. (2003)
• Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer. (PubMed id 12529348)^{3, 6} Shaheen N.J....Sandler R.S. (2003)
• Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population. (PubMed id 11857056)^{3, 6} Lio D....Caruso C. (2002)
• Hemochromatosis (HFE) and transferrin receptor-1 (TFRC1) genes in sporadic porphyria cutanea tarda (sPCT). (PubMed id 11929045)^{3, 6} Lamoril J....Puy H. (2002)
• [Mutations in the HFE gene (C282Y, H63D, S65C) in alcoholic patients with finding of iron overload] (PubMed id 12361551)^{3, 6} Campos Franco J....Torre Carballada J.A. (2002)
• Genotyping of hemochromatosis-associated mutations in the HFE gene by PCR-RFLP and a novel reverse hybridization method. (PubMed id 11939483)^{3, 6} Koeken A....van Doorn L.J. (2002)
• HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity. (PubMed id 12085358)^{3, 6} Chitturi S....George J. (2002)
• A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 11257277)^{3, 6} Rasmussen M.L....Eckfeldt J.H. (2001)
• The HFE gene undergoes alternate splicing processes. (PubMed id 11001625)^{3, 4} Thenie A.... Mosser J. (2000)
• Two novel polymorphisms (E277K and V212V) in the haemochromatosis gene HFE. (PubMed id 10612845)^{3, 4} Bradbury R.... Payne S.J. (2000)
• A retrospective anonymous pilot study in screening newborns for HFE mutations in Scandinavian populations. (PubMed id 10094552)^{3, 4} Merryweather-Clarke A.T.... Robson K.J.H. (1999)
• HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis. (PubMed id 10194428)^{3, 4} Mura C.... Ferec C. (1999)
• Alternate splice variants of the hemochromatosis gene Hfe. (PubMed id 10079302)^{3, 4} Rhodes D.A. and Trowsdale J. (1999)
• Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. (PubMed id 11800564)^{1, 3} West A.P. Jr.... Bjorkman P.J. (2001)
• Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1. (PubMed id 19228389)^{1, 3} Mitchell R.M....Connor J.R. (2009)
• HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions. (PubMed id 17956864)^{1, 3} Chen J....Enns C.A. (2007)
• Apical distribution of HFE-beta2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells. (PubMed id 16841247)^{1, 3} Arredondo M....Nunez M.T. (2006)
• The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. (PubMed id 18524764)^{1, 3} Gao J....Enns C.A. (2008)
• The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment. (PubMed id 17543888)^{1, 3} Bhatt L....McCaffrey M.W. (2007)
• Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C. (PubMed id 17101320)^{1, 3} Bonkovsky H.L....Morishima C. (2006)
• Changes in erythropoiesis in hereditary hemochromatosis are not mediated by HFE expression in nucleated red cells. (PubMed id 15710569)^{1, 3} Feeney G.P....Worwood M. (2005)
• Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation. (PubMed id 12874382)^{1, 3} Zhang A.S....Enns C.A. (2003)
• The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin. (PubMed id 12464008)^{1, 3} Wang J....Pantopoulos K. (2003)
• The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. (PubMed id 10085150)^{1, 3} Roy C.N....Enns C.A. (1999)
• Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. (PubMed id 9371823)^{1, 3} Parkkila S....Sly W.S. (1997)
• Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations. (PubMed id 18452683)^{1, 3} Milward E.A....Olynyk J.K. (2008)
• Consequences of expressing mutants of the hemochromatosis gene (HFE) into a human neuronal cell line lacking endogenous HFE. (PubMed id 17194693)^{1, 3} Lee S.Y....Connor J.R. (2007)
• HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis. (PubMed id 16043695)^{1, 3} Drakesmith H....Xu X.N. (2005)
• Lack of evidence for the pathogenic role of iron and HFE gene mutations in Brazilian patients with nonalcoholic steatohepatitis. (PubMed id 12792703)^{1, 3} Deguti M.M....Cancado E.L. (2003)
• Distribution of C282Y and H63D mutations in the HFE gene in healthy Asian Indians and patients with thalassaemia major. (PubMed id 14765621)^{1, 3} Kaur G....Mehra N.K. (2003)
• Hepatitis C, iron status, and disease severity: relationship with HFE mutations. (PubMed id 12557137)^{1, 3} Tung B.Y....Kowdley K.V. (2003)
• HFE mutations in an inflammatory arthritis population. (PubMed id 11886966)^{1, 3} Willis G....Wimperis J.Z. (2002)
• Identification of an endogenous RNA transcribed from the antisense strand of the HFE gene. (PubMed id 11532995)^{1, 3} Thenie A.C....Mosser J. (2001)
• Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. (PubMed id 19001803)^{1, 3} Cribier B....Chosidow O. (2009)
• HFE genotype influences erythropoiesis support requirement in hemodialysis patients: a prospective study. (PubMed id 18025780)^{1, 3} Valenti L....Fargion S. (2008)
• Primary osteoarthritis in the ankle joint is associated with finger metacarpophalangeal osteoarthritis and the H63D mutation in the HFE gene: evidence for a hemochromatosis-like polyarticular osteoarthritis phenotype. (PubMed id 16755236)^{1, 3} Carroll G.J. (2006)
• Prevalence of HFE (hemochromatosis) gene mutations in patients with cluster headache. (PubMed id 16178952)^{1, 3} Rainero I....Pinessi L. (2005)
• Do cancer cells selectively mutate HFE to increase their intracellular iron? (PubMed id 16012706)^{1, 3} Muller C.I....Koeffler H.P. (2005)
• HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface. (PubMed id 15056661)^{1, 3} Giannetti A.M. and Bjorkman P.J. (2004)
• Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells. (PubMed id 15044462)^{1, 3} Davies P.S. and Enns C.A. (2004)
• Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences. (PubMed id 15546588)^{1, 3} Wang X.S....Connor J. (2004)
• Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE. (PubMed id 12707938)^{1, 3} Pulliam J.F....Markesbery W.R. (2003)
• Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments. (PubMed id 12667138)^{1, 3} Davies P.S....Enns C.A. (2003)
• Frequency of HFE gene mutations in Iranian beta-thalassaemia minor patients. (PubMed id 14703689)^{1, 3} Jazayeri M....Zali M.R. (2003)
• The hemochromatosis protein HFE inhibits iron export from macrophages. (PubMed id 12429850)^{1, 3} Drakesmith H....Townsend A.R. (2002)
• HFE mutations and transferrin receptor polymorphism analysis in porphyria cutanea tarda: a prospective study of 36 cases from southern France. (PubMed id 11260010)^{1, 3} Dereure O....Guilhou J.J. (2001)
• Mutation analysis of the HFE gene in German hemochromatosis patients and controls using automated SSCP-based capillary electrophoresis and a new PCR-ELISA technique. (PubMed id 11686223)^{1, 3} Hellerbrand C....Buttner R. (2001)
• Mutant HFE genotype leads to significant iron overload in patients with liver diseases from western Romania. (PubMed id 19433916)^{1, 3} Neghina A.M....Thorstensen K. (2009)
• High prevalence of HFE gene mutations in hemodialysis patients. (PubMed id 18500222)^{1, 3} Mennella G....Gessoni G. (2008)
• [The prevalence of peripheral iron overload and the presence of HFE gene (H63D) mutation among the Korean patients with nonalcoholic fatty liver disease] (PubMed id 17585191)^{1, 3} Lee D....Lee D.H. (2007)
• The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population. (PubMed id 17210810)^{1, 3} Sutedja N.A....Van den Berg L.H. (2007)
• HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls. (PubMed id 16454835)^{1, 3} Gleeson D....Dalton A. (2006)
• Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations. (PubMed id 15637751)^{1, 3} Duseja A....Chawla Y. (2005)
• Effects of HFE gene mutations and alcohol on iron status, liver biochemistry and morbidity. (PubMed id 16105133)^{1, 3} Olynyk J.K....Powell L.W. (2005)
• HFE gene mutations in susceptibility to childhood leukemia: HuGE review. (PubMed id 15775751)^{1, 3} Dorak M.T....Worwood M. (2005)
• Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan. (PubMed id 15991291)^{1, 3} Lin T.J....Liao L.Y. (2005)
• Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C. (PubMed id 14996353)^{1, 3} Lebray P....Nalpas B. (2004)
• Prevalence of HFE mutations among the Thai population and correlation with iron loading in haemoglobin E disorder. (PubMed id 15182337)^{1, 3} Viprakasit V....Tanphaichitr V.S. (2004)
• HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. (PubMed id 12586300)^{1, 3} Erhardt A....Haussinger D. (2003)
• Mixture distribution analysis of phenotypic markers reflecting HFE gene mutations. (PubMed id 12907432)^{1, 3} McLaren C.E....Gordeuk V.R. (2003)
• Association between HFE mutations and acute myocardial infarction: a study in patients from Northern and Southern Italy. (PubMed id 12850485)^{1, 3} Candore G....Caruso C. (2003)
• Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2. (PubMed id 12656741)^{1, 3} Hannuksela J....Sly W.S. (2003)
• HFE mutations and hemochromatosis in Danish patients admitted for HFE genotyping. (PubMed id 12512743)^{1, 3} Koefoed P....Nielsen F.C. (2002)
• Prevalence of coronary heart disease associated with HFE mutations in adults attending a health appraisal center. (PubMed id 12427496)^{1, 3} Waalen J....Beutler E. (2002)
• Mutations in the HFE gene and their interaction with exogenous risk factors in hepatocellular carcinoma. (PubMed id 11500061)^{1, 3} Fargion S....Fiorelli G. (2001)
• Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. (PubMed id 11027676)^{1, 3} West A.P....Bjorkman P.J. (2000)

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