Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HEYL Gene

protein-coding GIFtS: 56
GCID: GC01M040119

hairy/enhancer-of-split related with YRPW motif-like

Explore 2 diseases affiliated with
HEYL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hairy/Enhancer-Of-Split Related With YRPW Motif-Like¹ ²		HHRT3¹
BHLHb33¹		HHeyL¹
HEY3¹ ²		Hairy/Enhancer-Of-Split Related With YRPW Motif 3²
Class B Basic Helix-Loop-Helix Protein 33² ³		Hairy/Enhancer-Of-Split Related With YRPW Motif-Like Protein²
Hairy-Related Transcription Factor 3² ³		HEY-Like Protein²
HRT-3² ³		BHLHB33³
HRT3² ³

External Ids:	HGNC: 4882¹	Entrez Gene: 26508²	Ensembl: ENSG00000163909⁷	OMIM: 609034⁵	UniProtKB: Q9NQ87³

Export aliases for HEYL gene to outside databases

Previous GC identifers: GC01M039093 GC01M039553 GC01M039503 GC01M039492 GC01M039741 GC01M039862 GC01M038207

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HEYL:

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix

(bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain,

but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and

a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological

validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HEYL_HUMAN, Q9NQ87

Function: Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity).

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity).

Represses transcription by the cardiac transcriptional activators GATA4 and GATA6

Gene Wiki entry for HEYL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HEYL gene promoter:
SRF Tal-1 SRF (504 AA) Tal-1beta LCR-F1 E47 AREB6 CREB deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HEYL promoter sequence

Search SABiosciences Chromatin IP Primers for HEYL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEYL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.3

HEYL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEYL gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M040119: view genomic region (about GC identifiers)

Start:	40,089,103 bp from pter	End:	40,105,617 bp from pter
Size:	16,515 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HEYL_HUMAN, Q9NQ87 (See protein sequence)

Recommended Name: Hairy/enhancer-of-split related with YRPW motif-like protein

Size: 328 amino acids; 35087 Da

Subunit: Self-associates (By similarity). Interacts with GATA4, GATA6, HES1, HEY1 and HEY2 (By similarity). Interacts

with HDAC1, NCOR1 and SIN3A (By similarity)

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q5TG99

Explore the universe of human proteins at neXtProt for HEYL: NX_Q9NQ87

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQ87

HEYL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055386.1

ENSEMBL proteins:

ENSP00000361943 ENSP00000439071

Reactome Protein details: Q9NQ87
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: HEYL OriGene Custom Protein Services for HEYL
	GenScript Custom Purified and Recombinant Proteins Services for HEYL
	Novus Biologicals HEYL Proteins Novus Biologicals HEYL Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HEYL

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	ISS	--

HEYL for ontologies About GeneDecksing

HEYL Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HEYL
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HEYL
	GenScript Custom Superior Antibodies Services for HEYL
	Novus Biologicals HEYL Antibodies
	Search for Antibodies for HEYL at Abcam
	Uscn Antibodies for HEYL
	ThermoFisher Antibodies for HEYL

Assay Products for HEYL:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HEYL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HEYL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HEYL for domains About GeneDecksing

3 InterPro domains/families:

IPR018352 Orange_subgr

IPR003650 Orange

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry Q9NQ87

ProtoNet protein and cluster: Q9NQ87

2 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB003650 Orange

UniProtKB/Swiss-Prot: HEYL_HUMAN, Q9NQ87

Similarity: Belongs to the HEY family

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 Orange domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HEYL_HUMAN, Q9NQ87

Function: Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity).

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity).

Represses transcription by the cardiac transcriptional activators GATA4 and GATA6

Induction: By activation of the Notch signaling pathway

miRNA Products:		OriGene 3'-UTR Clone: HEYL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEYL
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate HEYL (see all 34):
		hsa-miR-330-5p hsa-miR-29a hsa-miR-765 hsa-miR-3921 hsa-miR-4314 hsa-miR-1276 hsa-miR-4274 hsa-miR-508-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEYL (see all 7) OriGene shRNA RFP: HEYL OriGene siRNA: HEYL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEYL

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HEYL

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEYL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEYL OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HEYL (NM_014571)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEYL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEYL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HEYL
		LifeMap BioReagents: cell line associated with HEYL: PureStem ES-210, Ecto-ntu Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEYL

Gene Ontology (GO): 13 molecular function terms (GO ID links to tree view) (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IEA	--
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity	ISS	--
GO:0000988	protein binding transcription factor activity	IDA	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0001106	RNA polymerase II transcription corepressor activity	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	15485867
GO:0003714	transcription corepressor activity	IDA	--
GO:0005515	protein binding	IPI	--
GO:0008134	transcription factor binding	NAS	17611704
GO:0035939	microsatellite binding	IDA	--
GO:0042803	protein homodimerization activity	IEA	--
GO:0046982	protein heterodimerization activity	IDA	--
GO:0050683	AF-1 domain binding	IPI	--

HEYL for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for HEYL: Heyl^tm1.2Abmu Heyl^tm1Kkb
     8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Heyl):

cardiovascular system	cellular	growth/size	mortality/aging	muscle
nervous system	no phenotypic analysis	normal

HEYL for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

8/12 pathways (see all 12)
Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.00	Signaling by NOTCH1	1.00
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.00	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.79
Signaling by NOTCH1 in Cancer	1.00	Signaling by NOTCH	0.77
Signaling by NOTCH1 HD Domain Mutants in Cancer	1.00	NOTCH1 Intracellular Domain Regulates Transcription	0.65

Disease

Disease

1.00

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/14 Reactome Pathways for HEYL (see all 14)

	NOTCH1 Intracellular Domain Regulates Transcription
	Signaling by NOTCH
	NOTCH1 PEST domain mutants stimulate HEY transcription
	FBXW7 Mutants and NOTCH1 in Cancer
	NOTCH1 stimulates HEY transcription

HEYL for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HEYL

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/25 Interacting proteins for HEYL (Q9NQ87^{2, 3} ENSP00000361943⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RBPMS	Q93062²^,³, ENSP00000340176⁴	MINT-68017 I2D: score=5 STRING: ENSP00000340176
SMAD3	P84022²^,³, ENSP00000332973⁴	MINT-61698 I2D: score=3 STRING: ENSP00000332973
SMAD7	O15105²^,³, ENSP00000262158⁴	MINT-61810 I2D: score=3 STRING: ENSP00000262158
ATF7IP	Q6VMQ6²^,³	MINT-61887 I2D: score=3
LAPTM5	Q13571²^,³	MINT-62169 I2D: score=3

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	--	--
GO:0003151	outflow tract morphogenesis	ISS	--
GO:0003181	atrioventricular valve morphogenesis	ISS	--
GO:0003184	pulmonary valve morphogenesis	ISS	--
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	ISS	--

HEYL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HEYL
Search CenterWatch for drugs/clinical trials and news about HEYL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HEYL gene:

NM_014571.3

Unigene Cluster for HEYL:

Hairy/enhancer-of-split related with YRPW motif-like

Hs.472566 [show with all ESTs]

Unigene Representative Sequence: NM_014571

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372852(uc010oiw.2 uc001cdp.3) ENST00000535435

miRNA Products:		OriGene 3'-UTR Clone: HEYL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEYL
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate HEYL (see all 34):
		hsa-miR-330-5p hsa-miR-29a hsa-miR-765 hsa-miR-3921 hsa-miR-4314 hsa-miR-1276 hsa-miR-4274 hsa-miR-508-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEYL (see all 7) OriGene shRNA RFP: HEYL OriGene siRNA: HEYL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEYL

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEYL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEYL OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HEYL (NM_014571)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEYL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEYL

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEYL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HEYL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEYL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEYL

Additional cDNA sequence:

AF311885.1 AJ272215.1 AK300463.1 BC006087.1

6 DOTS entries:

DT.410891 DT.121407082 DT.100710319 DT.100732082 DT.100751632 DT.92450621

24/139 AceView cDNA sequences (see all 139):

AA916553 AL040198 CK819944 AI570320 BM693247 AI417209 R74338 AA861456

AA973148 BC006087 AJ272215 NM_014571 CD518041 BE205999 BQ027529 AA969508

AA009821 AI674102 AA453276 BF435697 BM354043 BU785900 AA935671 CD246075

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HEYL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTGTTGCG

About this image

HEYL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Kidney

Interstitial Stroma

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)

Bone

See HEYL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HEYL

SOURCE GeneReport for Unigene cluster: Hs.472566

SABiosciences Expression via Pathway-Focused PCR Arrays including HEYL:

Notch Signaling Targets in human mouse rat

Neurogenesis in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

Notch Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEYL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HEYL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEYL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEYL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEYL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HEYL gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	HEYL¹	hairy/enhancer-of-split related with YRPW motif-like	66.77(n) 63.55(a)	771101 XM_001234405.2 XP_001234406.2
zebrafish (Danio rerio)	Actinopterygii	heyl¹	hairy/enhancer-of-split related with YRPW motif-like	53.59(n) 50.98(a)	335134 NM_181736.1 NP_859425.1
fruit fly (Drosophila melanogaster)	Insecta	Hey³	transcription factor	57(a)	44A2 --

ENSEMBL Gene Tree for HEYL (if available)
TreeFam Gene Tree for HEYL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HEYL gene

HES4² HES6² HELT² HEY2² HES7² HES3² HES5² HEY1²

HES2² HES1²

6 SIMAP similar genes for HEYL using alignment to 2 protein entries: HEYL_HUMAN (see all proteins):

HEY1 OAF1 HEY2 HES4 HES5 HELT

HEYL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77962326^1,2	C,F,	--	40088630(+)	`TACCCG/TCTTGA`	1	--	ds500¹		1		EA	120
rs189434277^1,2		--	40088659(+)	`ATACCC/TCAACT`	1	--	ds500¹		0	--	--	--	--
rs115202853^1,2	C,	--	40088731(+)	`ATGGAA/GGGTGT`	1	--	ds500¹		0	--	--	--	--
rs185757676^1,2		--	40088743(+)	`CCCCCA/CACTCA`	1	--	ds500¹		0	--	--	--	--
rs12029569^1,2	C,F,A,H,	--	40088816(+)	`GTGTTC/AGTTGG`	1	--	ds500¹		12		NS EA NA	1494
rs75189707^1,2	F,	--	40088817(+)	`TGTTCG/ATTGGA`	1	--	ds500¹		1		NA	120
rs189693750^1,2		--	40089155(+)	`AGGCCC/TTGTGC`	1	--	ut3¹		0	--	--	--	--
rs12022423^1,2	C,A,	--	40089370(+)	`GCAACG/TTTGAA`	1	--	ut3¹		3		NA EA	124
rs114297514^1,2	C,F,	--	40089408(+)	`AGCCAT/GGCACA`	1	--	ut3¹		1		WA	118
rs116401702^1,2	F,	--	40089425(+)	`GGGAAG/TAGCAT`	1	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for HEYL (40089103 - 40105617 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HEYL: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEYL

DNA2.0 Custom Variant and Variant Library Synthesis for HEYL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HEYL for disorders           About GeneDecksing

OMIM gene information: 609034    OMIM disorders: --

2 diseases for HEYL:    About MalaCards

glaucoma neuronitis

1 disease from the University of Copenhagen DISEASES database for HEYL:

Glaucoma

Export disorders for HEYL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HEYL gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with HEYL)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. (PubMed id 10860664)^{1, 2, 3, 9} Steidl C....Gessler M. (2000)
Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. (PubMed id 15485867)^{1, 2} Kathiriya I.S.... Nakagawa O. (2004)
Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. (PubMed id 10964718)^{1, 2} Maier M.M. and Gessler M. (2000)
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. (PubMed id 11095750)^{1, 2} Nakagawa O.... Olson E.N. (2000)
Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis. (PubMed id 10415358)^{1, 3} Leimeister C.... Gessler M. (1999)
Differential effects of the HESR/HEY transcription fa ctor family on dopamine transporter reporter gene expression via variable numbe r of tandem repeats. (PubMed id 21290414)¹ Kanno K. and Ishiura S. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Repression of androgen receptor activity by HEYL, a t hird member of the Hairy/Enhancer-of-split-related family of Notch effectors. (PubMed id 21454491)¹ Lavery D.N....Bevan C.L. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 26508	HGNC: 4882	AceView: HEYL	Ensembl:ENSG00000163909	euGenes: HUgn26508
ECgene: HEYL	H-InvDB: HEYL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HEYL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HEYL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HEYL gene:
Search GeneIP for patents involving HEYL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of HEYL
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HEYL
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEYL		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEYL
	OriGene Protein Over-expression Lysate for HEYL		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HEYL		OriGene 3'-UTR Clone for HEYL
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEYL		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEYL
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HEYL		OriGene Custom Protein Services for HEYL
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HEYL
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEYL
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEYL
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEYL
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEYL
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEYL

	GenScript Custom Purified and Recombinant Proteins Services for HEYL		GenScript cDNA clones with any tag delivered in your preferred vector for HEYL
	GenScript Custom Assay Services for HEYL		GenScript Custom Superior Antibodies Services for HEYL
	GenScript Custom overexpressing Cell Line Services for HEYL		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HEYL promoter
	Search Chromatin IP Primers for HEYL
	RT² qPCR Primer Assay in human, mouse, rat HEYL
	Search GNC Networks for HEYL
	SABiosciences PCR Arrays including human, mouse, rat HEYL

Search Tocris compounds for HEYL

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HEYL antibodies
	HEYL proteins
	HEYL lysates

	Search for Antibodies for HEYL at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HEYL
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HEYL Proteins, Antibodies, CLIAs, and ELISAs

Cell Line associated with HEYL: PureStem ES-210, Ecto-ntu Progenitor

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEYL

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HEYL
	SwitchGear Promoter luciferase reporter plasmids for HEYL

ThermoFisher Antibodies for HEYL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEYL

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HEYL gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HEYL Gene

hairy/enhancer-of-split related with YRPW motif-like

Aliases
for HEYL gene

Summaries
for HEYL gene

Genomic Views
for HEYL gene

Proteins
for HEYL gene

Protein Domains /
Families
for HEYL gene

Function
for HEYL gene

Pathways & Interactions
for HEYL gene

Drugs & Compounds
for HEYL gene

Transcripts
for HEYL gene

Expression
for HEYL gene

Orthologs
for HEYL gene

Paralogs
for HEYL gene

Genomic Variants
for HEYL gene

Disorders / Diseases
for HEYL gene

Publications
for HEYL gene

External Searches for HEYL gene

Genome Databases showing HEYL gene

Other Databases showing HEYL gene

Specialized Databases showing HEYL gene

Intellectual Property
for HEYL gene

Products
for HEYL gene

View Random Gene

Advanced Search

Export list of displayed genes

HEYL Gene

hairy/enhancer-of-split related with YRPW motif-like

Aliasesfor HEYL gene

Summariesfor HEYL gene

Genomic Viewsfor HEYL gene

Proteinsfor HEYL gene

Protein Domains /Familiesfor HEYL gene

Functionfor HEYL gene

Pathways & Interactionsfor HEYL gene

Drugs & Compoundsfor HEYL gene

Transcriptsfor HEYL gene

Expression for HEYL gene

Orthologsfor HEYL gene

Paralogsfor HEYL gene

Genomic Variantsfor HEYL gene

Disorders / Diseasesfor HEYL gene

Publicationsfor HEYL gene

External Searches for HEYL gene

Genome Databases showing HEYL gene

Other Databases showing HEYL gene

Specialized Databases showing HEYL gene

Intellectual Propertyfor HEYL gene

Productsfor HEYL gene

View Random Gene

Aliases
for HEYL gene

Summaries
for HEYL gene

Genomic Views
for HEYL gene

Proteins
for HEYL gene

Protein Domains /
Families
for HEYL gene

Function
for HEYL gene

Pathways & Interactions
for HEYL gene

Drugs & Compounds
for HEYL gene

Transcripts
for HEYL gene

Expression
for HEYL gene

Orthologs
for HEYL gene

Paralogs
for HEYL gene

Genomic Variants
for HEYL gene

Disorders / Diseases
for HEYL gene

Publications
for HEYL gene

Intellectual Property
for HEYL gene

Products
for HEYL gene