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HEY2 Gene

protein-coding GIFtS: 59

GC06P126112

hairy/enhancer-of-split related with YRPW motif 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CHF1 ^², ³
GRIDLOCK ^²
GRL ^², ³, ⁵
HERP ^³
HERP1 ^², ³, ⁵
HESR-2 ^³
HESR2 ^²
HRT2 ^², ³
MGC10720 ^²
OTTHUMP00000017138 ^²
bHLHb32 ^¹, ²
hCHF1 ^³
hHRT2 ^³

Descriptions
Cardiovascular helix-loop-helix factor 1 ^³
HES-related repressor protein 1 ^²
HES-related repressor protein 2 ^³
Hairy and enhancer of split-related protein 2 ^³
Hairy-related transcription factor 2 ^², ³
Protein gridlock homolog ^³
cardiovascular basic helix-loop-helix factor 1 ^²
hairy/enhancer-of-split related with YRPW motif 2 ^²

External Ids
HGNC: 4881¹
Entrez Gene: 23493²
UniProtKB: Q9UBP5³
Ensembl: ENSG00000135547⁷

Search outside databases for aliases for HEY2 gene

Previous GC identifers: GC06P125730 GC06P125917 GC06P126003 GC06P126051

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HEY2:

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic

helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or

hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to

repress transcription. Expression of this gene is induced by the Notch signal transduction

pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular

development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced

transcript variants have been found, but their biological validity has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: HEY2_HUMAN, Q9UBP5

Function: Downstream effector of Notch signaling which may be required for cardiovascular

development. Transcriptional repressor which binds preferentially to the canonical E box sequence

5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6

Gene Wiki entry for HEY2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HEY2 gene

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q22.31 HGNC cytogenetic band: 6q

HEY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P126112: (about GC identifiers)

Start:	126,110,503 bp from pter
End:	126,124,108 bp from pter
Size:	13,606 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HEY2_HUMAN, Q9UBP5 (See protein sequence)

Recommended Name: Hairy/enhancer-of-split related with YRPW motif protein 2

Size: 337 amino acids; 35808 Da

Subunit: May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity).

Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6

Subcellular location: Nucleus (By similarity)

REFSEQ proteins: NP_036391.1

ENSEMBL proteins:

ENSP00000357348 ENSP00000357349

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HEY2)
	Human Recombinant Proteins from Abnova (HEY2)

OriGene Purified Recombinant Human Protein: HEY2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for HEY2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HEY2
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (HEY2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HEY2)
	Novus Biologicals Antibody for HEY2

Assays for HEY2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UBP5

ProtoNet protein and cluster: Q9UBP5

2 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB003650 Orange

UniProtKB/Swiss-Prot: HEY2_HUMAN, Q9UBP5

Similarity: Belongs to the HEY family

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 Orange domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HEY2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HEY2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_012259

Applied Biosystems Silencer® siRNAs for HEY2

Sigma-Aldrich siRNA for HEY2

Sigma-Aldrich shRNA for HEY2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HEY2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012259
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012259
untagged cDNA clone in CMV expression vector: NM_012259

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC007707

UniProtKB/Swiss-Prot: HEY2_HUMAN, Q9UBP5

Function: Downstream effector of Notch signaling which may be required for cardiovascular

development. Transcriptional repressor which binds preferentially to the canonical E box sequence

5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6

10 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hey2):

	craniofacial	embryogenesis	growth/size	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	muscle	nervous system	respiratory system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	10415358

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for HEY2 (Your Favorite Gene powered by Ingenuity)

Notch Signaling

GeneDecks HEY2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for HEY2

5/21 Interacting proteins for HEY2 (Q9UBP5² ENSP00000357348³) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLSCR1	O15162²	MINT-67859
NOTCH1	ENSP00000360765³	STRING (score=.985)
GATA4	ENSP00000334458³	STRING (score=.951)
FOXC2	ENSP00000326371³	STRING (score=.925)
TBX2	ENSP00000240328³	STRING (score=.924)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007219	Notch signaling pathway	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007399	nervous system development	TAS	10415358
GO:0009887	organ morphogenesis	TAS	10415358

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HEY2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HEY2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HEY2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_012259

Sigma-Aldrich siRNA for HEY2

Sigma-Aldrich shRNA for HEY2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012259

REFSEQ mRNAs for HEY2 gene:

NM_012259.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012259

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012259
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012259
                                 untagged cDNA clone in CMV expression vector: NM_012259

Additional cDNA sequence:

AB044755.1 AF173901.1 AF232238.1 AF237949.1 AF311884.1 AJ249545.1 AK289943.1 AK303890.1

BC007707.2 BT020067.1 BT020068.1 CR596074.1

1 DOTS entry:

DT.40112713

24/52 AceView cDNA sequences (see all 52 ):

BM669820 AF311884 AF237949 BM726187 AI797772 CR596074 AI989833 AI299482

BM699158 BC007707 BM721133 NM_012259 AA884571 AJ249545 AA116068 CA425373

BM679557 AB044755 AL541730 CD250536 BE468134 CA450231 AI695960 BI560995

highest scoring ESTs for HEY2:

AA116068 N46845 AA884571 AB044755 AF173901 AF232238 AF237949 AF311884 AI299482 AI695960

Unigene Cluster for HEY2:

Hairy/enhancer-of-split related with YRPW motif 2

Hs.144287 [show with all ESTs]

Unigene Representative Sequence: NM_012259

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000368364 ENST00000368365

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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HEY2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HEY2

¹ / ² / ³

6 probe-sets matching HEY2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
79699_at²^{, 3}	U95-D	1	1.00	1.00	0.98	0.96	AA116068	1.00	1.00	1.00	1
46813_at²^{, 3}	U95-B	1	1.00	1.00	0.98	1.04	N46845	1.00	1.00	1.00	1
222921_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF232238	0.80	1.00	0.91	1
219743_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012259	0.60	1.00	0.82	1
222921_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219743_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HEY2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATTATGCAC

SOURCE GeneReport for Unigene cluster: Hs.144287

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HEY2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	HEY2¹	--	hairy/enhancer-of-split related with YRPW motif 2	99.6(n) 100(a)	472118 XM_527497.2 XP_527497.2
cow (Bos taurus)	HEY2¹	--	hairy/enhancer-of-split related with YRPW motif 2	90.31(n) 98.22(a)	538619 XM_581531.3 XP_581531.2
rat (Rattus norvegicus)	Hey2¹	--	hairy/enhancer-of-split related with YRPW motif 2	86.75(n) 94.66(a)	155430 XM_344806.3 XP_344807.2
mouse (Mus musculus)	Hey2^{1, 5}	10⁵	hairy/enhancer-of-split related with YRPW motif 2^{1, 5}	86.94(n)¹ 94.07(a)¹	15214¹ NM_013904.1¹ NP_038932.1¹ AB093589⁵ AF172287⁵ (see all 15)
chicken (Gallus gallus)	HEY2¹	--	hairy/enhancer-of-split related with YRPW motif 2	81.74(n) 91.32(a)	421718 XM_419754.2 XP_419754.2

About this table Species with no ortholog for HEY2

ENSEMBL Gene Tree for HEY2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HEY2 gene

HEYL² HEY1² HELT²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/46 NCBI SNPs in HEY2 are shown (see all 46 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 41)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1343116^1,2	A,C,F,H	126111395(-)	`AAACAT/GGTTTT`	1	--	ng5¹		5		MN EU EA WA	600
	rs1343115^1,2	A,C,F	126111510(-)	`CGGGAC/GGTGAA`	1	--	ng5¹		3		MN NA	366
	rs1935983^1,2	A,C	126110607(-)	`GCGCCA/GGTCGC`	1	--	ng5¹		0	--	--	--	--
--	rs7764016^1,2	A,C	126112482(+)	`GCCGCG/TAGGAG`	1	--	ut5¹ ese³		0	--	--	--	--
	rs3757217^1,2	A,C	126111329(-)	`TGCGTC/GTGCGA`	1	--	ng5¹		0	--	--	--	--
	rs3799709^1,2	A,C,F,H	126120054(-)	`GGTAAC/TGAATA`	1	--	int¹		22		EA NS NA EU WA	2994
	rs3799711^1,2	A,C,F,H	126117006(-)	`ATTTCG/AGTTGT`	1	--	int¹		18		EA NS EU WA NA	2796
	rs3799708^1,2	A,C,F,H	126120223(-)	`AAAAAT/CAGTTA`	1	--	int¹		9		EA EU WA NA	2074
	rs3799712^1,2	A,C,F,H	126116796(-)	`AGTCCC/TGAAAT`	1	--	int¹		4		EU EA WA	412
	rs7748729^1,2	A,C,F	126119074(+)	`TCAGGT/CCATTG`	1	--	int¹		2		NA	182

About this table

HapMap Linkage Disequilibrium images for HEY2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604674

UniProtKB/Swiss-Prot: HEY2_HUMAN, Q9UBP5

Defects in HEY2 may be involved in atrioventricular septal defects (AVSD)

Genetic Association Database: HEY2
Human Genome Epidemiology Navigator: HEY2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/34 PubMed articles for HEY2 gene (see all 34 ):

Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis. (PubMed id 10415358)^{2, 3, 4} Leimeister C.... Gessler M. (1999)
HERP, a new primary target of Notch regulated by ligand binding. (PubMed id 11486044)^{1, 3, 4} Iso T.... Hamamori Y. (2001)
HEY2 mutations in malformed hearts. (PubMed id 16329098)^{3, 4} Reamon-Buettner S.M. and Borlak J. (2006)
CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. (PubMed id 16293227)^{3, 4} Shirvani S.... Chin M.T. (2006)
ZFPM2/FOG2 and HEY2 genes analysis in nonsyndromic tricuspid atresia. (PubMed id 15643620)^{3, 6} Sarkozy A....Dallapiccola B. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. (PubMed id 11095750)^{3, 4} Nakagawa O.... Olson E.N. (2000)
Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. (PubMed id 10692439)^{3, 4} Chin M.T.... Lee M.-E. (2000)
Gridlock, an HLH gene required for assembly of the aorta in zebrafish. (PubMed id 10710309)^{3, 4} Zhong T.P....Fishman M.C. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23493	HGNC: 4881	AceView: HEY2	Ensembl:ENSG00000135547	euGenes: HUgn23493
ECgene: HEY2	H-InvDB: HEY2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HEY2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HEY2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HEY2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HEY2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HEY2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HEY2)
	Antibodies (HEY2)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (HEY2)
	Antibodies (HEY2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for HEY2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HEY2

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HEY2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for HEY2

Summaries
for HEY2

Genomic Location
for HEY2

Proteins
for HEY2

Protein Domains/
Families
for HEY2

Gene Function
for HEY2

Pathways & Interactions
for HEY2

Drugs & Compounds
for HEY2

Transcripts
for HEY2

Expression
for HEY2

Orthologs
for HEY2

Paralogs
for HEY2

SNPs/Variants
for HEY2

Disorders & Mutations
for HEY2

Medical News
for HEY2

Publications
for HEY2

Search for HEY2

Genome Databases showing HEY2

Other Databases showing HEY2

Specialized Databases showing HEY2

Licensable Technologies
for HEY2

Services
for HEY2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HEY2 (Gene Symbol)
CHF1
GRIDLOCK
GRL
HERP
HERP1
HESR-2
HESR2
HRT2
MGC10720
OTTHUMP00000017138
bHLHb32
hCHF1
hHRT2
Cardiovascular helix-loop-helix factor 1
HES-related repressor protein 1
HES-related repressor protein 2
Hairy and enhancer of split-related protein 2
Hairy-related transcription factor 2
Protein gridlock homolog
cardiovascular basic helix-loop-helix factor 1
hairy/enhancer-of-split related with YRPW motif 2

HEY2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor HEY2

Summariesfor HEY2

Genomic Locationfor HEY2

Proteinsfor HEY2

Protein Domains/Familiesfor HEY2

Gene Functionfor HEY2

Pathways & Interactionsfor HEY2

Drugs & Compoundsfor HEY2

Transcriptsfor HEY2

Expression for HEY2

Orthologsfor HEY2

Paralogsfor HEY2

SNPs/Variantsfor HEY2

Disorders & Mutationsfor HEY2

Medical Newsfor HEY2

Publicationsfor HEY2

Search for HEY2

Genome Databases showing HEY2

Other Databases showing HEY2

Specialized Databases showing HEY2

Licensable Technologiesfor HEY2

Servicesfor HEY2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HEY2

Summaries
for HEY2

Genomic Location
for HEY2

Proteins
for HEY2

Protein Domains/
Families
for HEY2

Gene Function
for HEY2

Pathways & Interactions
for HEY2

Drugs & Compounds
for HEY2

Transcripts
for HEY2

Expression
for HEY2

Orthologs
for HEY2

Paralogs
for HEY2

SNPs/Variants
for HEY2

Disorders & Mutations
for HEY2

Medical News
for HEY2

Publications
for HEY2

Licensable Technologies
for HEY2

Services
for HEY2