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Aliases for HEY2 Gene

Aliases for HEY2 Gene

  • Hes-Related Family BHLH Transcription Factor With YRPW Motif 2 2 3
  • HERP1 3 4 6
  • GRL 3 4 6
  • Hairy/Enhancer-Of-Split Related With YRPW Motif 2 2 3
  • Hairy And Enhancer Of Split-Related Protein 2 3 4
  • Class B Basic Helix-Loop-Helix Protein 32 3 4
  • Cardiovascular Helix-Loop-Helix Factor 1 3 4
  • Hairy-Related Transcription Factor 2 3 4
  • HES-Related Repressor Protein 2 3 4
  • Protein Gridlock Homolog 3 4
  • BHLHb32 3 4
  • HESR-2 3 4
  • HRT-2 3 4
  • HCHF1 3 4
  • HHRT2 3 4
  • CHF1 3 4
  • HRT2 3 4
  • Hairy/Enhancer-Of-Split Related With YRPW Motif Protein 2 3
  • Cardiovascular Basic Helix-Loop-Helix Factor 1 3
  • HES-Related Repressor Protein 1 3
  • GRIDLOCK 3
  • HESR2 3
  • HERP 4

External Ids for HEY2 Gene

Previous GeneCards Identifiers for HEY2 Gene

  • GC06P125917
  • GC06P126003
  • GC06P126051
  • GC06P126112
  • GC06P126068
  • GC06P123645

Summaries for HEY2 Gene

Entrez Gene Summary for HEY2 Gene

  • This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HEY2 Gene

HEY2 (Hes-Related Family BHLH Transcription Factor With YRPW Motif 2) is a Protein Coding gene. Diseases associated with HEY2 include tricuspid valve stenosis and tricuspid atresia. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is HEYL.

UniProtKB/Swiss-Prot for HEY2 Gene

  • Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5-CACGTG-3. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

Gene Wiki entry for HEY2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEY2 Gene

Genomics for HEY2 Gene

Regulatory Elements for HEY2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HEY2 Gene

Start:
125,747,664 bp from pter
End:
125,761,269 bp from pter
Size:
13,606 bases
Orientation:
Plus strand

Genomic View for HEY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEY2 Gene

Proteins for HEY2 Gene

  • Protein details for HEY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBP5-HEY2_HUMAN
    Recommended name:
    Hairy/enhancer-of-split related with YRPW motif protein 2
    Protein Accession:
    Q9UBP5
    Secondary Accessions:

    Protein attributes for HEY2 Gene

    Size:
    337 amino acids
    Molecular mass:
    35808 Da
    Quaternary structure:
    • May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6.

neXtProt entry for HEY2 Gene

Proteomics data for HEY2 Gene at MOPED

Post-translational modifications for HEY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEY2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HEY2 Gene

Domains for HEY2 Gene

Gene Families for HEY2 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for HEY2 Gene

Suggested Antigen Peptide Sequences for HEY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBP5

UniProtKB/Swiss-Prot:

HEY2_HUMAN :
  • Q9UBP5
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
Family:
  • Belongs to the HEY family.
genes like me logo Genes that share domains with HEY2: view

Function for HEY2 Gene

Molecular function for HEY2 Gene

UniProtKB/Swiss-Prot Function: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5-CACGTG-3. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

Gene Ontology (GO) - Molecular Function for HEY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity ISS --
GO:0000988 protein binding transcription factor activity IDA 21290414
GO:0001102 RNA polymerase II activating transcription factor binding IPI 16293227
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 15485867
genes like me logo Genes that share ontologies with HEY2: view
genes like me logo Genes that share phenotypes with HEY2: view

Animal Models for HEY2 Gene

MGI Knock Outs for HEY2:

Animal Model Products

CRISPR Products

miRNA for HEY2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEY2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HEY2 Gene

Localization for HEY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEY2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEY2 Gene COMPARTMENTS Subcellular localization image for HEY2 gene
Compartment Confidence
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for HEY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0016580 colocalizes_with Sin3 complex IDA 11486045
GO:0017053 transcriptional repressor complex IDA 11486045
genes like me logo Genes that share ontologies with HEY2: view

Pathways for HEY2 Gene

genes like me logo Genes that share pathways with HEY2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HEY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 11486045
GO:0001568 blood vessel development --
GO:0001570 vasculogenesis ISS --
GO:0003150 muscular septum morphogenesis ISS --
GO:0003151 outflow tract morphogenesis ISS --
genes like me logo Genes that share ontologies with HEY2: view

Transcripts for HEY2 Gene

Unigene Clusters for HEY2 Gene

Hairy/enhancer-of-split related with YRPW motif 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEY2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEY2 Gene

No ASD Table

Relevant External Links for HEY2 Gene

GeneLoc Exon Structure for
HEY2
ECgene alternative splicing isoforms for
HEY2

Expression for HEY2 Gene

mRNA expression in normal human tissues for HEY2 Gene

mRNA differential expression in normal tissues according to GTEx for HEY2 Gene

This gene is overexpressed in Artery - Tibial (11.1), Heart - Left Ventricle (5.1), and Artery - Coronary (4.5).

SOURCE GeneReport for Unigene cluster for HEY2 Gene Hs.144287

genes like me logo Genes that share expressions with HEY2: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for HEY2 Gene

Orthologs for HEY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HEY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEY2 35
  • 99.6 (n)
  • 100 (a)
HEY2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HEY2 35
  • 90.31 (n)
  • 98.22 (a)
HEY2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEY2 35
  • 87.58 (n)
  • 90.85 (a)
HEY2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hey2 35
  • 86.94 (n)
  • 93.77 (a)
Hey2 16
Hey2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HEY2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HEY2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hey2 35
  • 86.84 (n)
  • 94.36 (a)
chicken
(Gallus gallus)
Aves LOC100858839 35
  • 79.07 (n)
  • 88.79 (a)
lizard
(Anolis carolinensis)
Reptilia HEY2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hey2 35
  • 73.19 (n)
  • 80.42 (a)
zebrafish
(Danio rerio)
Actinopterygii hey2 35
  • 70.47 (n)
  • 76.85 (a)
hey2 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hey 36
  • 28 (a)
OneToMany
Hey 37
  • 56 (a)
Species with no ortholog for HEY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEY2 Gene

ENSEMBL:
Gene Tree for HEY2 (if available)
TreeFam:
Gene Tree for HEY2 (if available)

Paralogs for HEY2 Gene

Paralogs for HEY2 Gene

Selected SIMAP similar genes for HEY2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HEY2: view

Variants for HEY2 Gene

Sequence variations from dbSNP and Humsavar for HEY2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1268078 -- 125,760,579(-) TAAAG(A/C)AGCAC utr-variant-3-prime
rs1343115 -- 125,748,671(-) CGGGA(C/G)GTGAA upstream-variant-2KB
rs1343116 -- 125,748,556(-) AAACA(G/T)GTTTT upstream-variant-2KB
rs1739369 -- 125,753,813(+) TGCTT(C/T)TTGTT intron-variant
rs1811852 -- 125,750,429(+) CTCAA(C/G)TCTGG intron-variant, upstream-variant-2KB

Relevant External Links for HEY2 Gene

HapMap Linkage Disequilibrium report
HEY2

PCR Panel Products

  • Copy Number PCR Panels: for HEY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HEY2 Gene

Disorders for HEY2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for HEY2 Gene including...

Search for HEY2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for HEY2 Gene

Relevant External Links for HEY2

Genetic Association Database (GAD)
HEY2
Human Genome Epidemiology (HuGE) Navigator
HEY2
genes like me logo Genes that share disorders with HEY2: view

No data available for UniProtKB/Swiss-Prot for HEY2 Gene

Publications for HEY2 Gene

  1. HERP, a new primary target of Notch regulated by ligand binding. (PMID: 11486044) Iso T. … Hamamori Y. (Mol. Cell. Biol. 2001) 3 4 23
  2. Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis. (PMID: 10415358) Leimeister C. … Gessler M. (Mech. Dev. 1999) 2 3 4
  3. Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. (PMID: 10692439) Chin M.T. … Lee M.-E. (J. Biol. Chem. 2000) 3 4
  4. Gridlock, an HLH gene required for assembly of the aorta in zebrafish. (PMID: 10710309) Zhong T.P. … Fishman M.C. (Science 2000) 3 4
  5. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M. … Katoh M. (Int. J. Oncol. 2007) 3 23

Products for HEY2 Gene

Sources for HEY2 Gene

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