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HEY1 Gene

protein-coding GIFtS: 56

GC08M080838

hairy/enhancer-of-split related with YRPW motif 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BHLHb31 ^¹, ²
CHF-2 ^¹, ³
CHF2 ^¹, ², ³
HERP2 ^¹, ², ³
HESR-1 ^¹, ³
HESR1 ^¹, ², ³
HRT-1 ^¹, ²
HRT1 ^³
MGC1274 ^²
OAF1 ^²
hHRT1 ^³

Descriptions
Cardiovascular helix-loop-helix factor 2 ^², ³
HES-related repressor protein 1 ^³
HES-related repressor protein 2 ^²
Hairy and enhancer of split-related protein 1 ^³
Hairy-related transcription factor 1 ^², ³
basic helix-loop-helix protein OAF1 ^²
hairy/enhancer-of-split related with YRPW motif 1 ^²

External Ids
HGNC: 4880¹
Entrez Gene: 23462²
UniProtKB: Q9Y5J3³
Ensembl: ENSG00000164683⁷

Search outside databases for aliases for HEY1 gene

Previous GC identifers: GC08M079562 GC08M080724 GC08M080399 GC08M080726

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for HEY1:

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR)

family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene

is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in

mouse are required for embryonic cardiovascular development, and are also implicated in

neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.

[provided by RefSeq]

UniProtKB/Swiss-Prot: HEY1_HUMAN, Q9Y5J3

Function: Downstream effector of Notch signaling which may be required for cardiovascular

development. Transcriptional repressor which binds preferentially to the canonical E box sequence

5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6

Gene Wiki entry for HEY1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HEY1 gene

Entrez Gene cytogenetic band: 8q21 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q21

HEY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M080838: (about GC identifiers)

Start:	80,838,800 bp from pter
End:	80,842,653 bp from pter
Size:	3,854 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HEY1_HUMAN, Q9Y5J3 (See protein sequence)

Recommended Name: Hairy/enhancer-of-split related with YRPW motif protein 1

Size: 304 amino acids; 32613 Da

Subunit: Self-associates (By similarity). Interacts with HES1 and HEYL (By similarity). Interacts

with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with GATA4 and GATA6 (By similarity).

Interacts with CCDC89/BOIP (By similarity)

Subcellular location: Nucleus (By similarity)

PDB structures from and Proteopedia :

2DB7 (3D)

Secondary accessions: Q5TZS3 Q9NYP4

REFSEQ proteins (2 alternative transcripts):

NP_001035798.1 NP_036390.3

ENSEMBL proteins:

ENSP00000338272 ENSP00000346761

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HEY1)
	Human Recombinant Proteins from Abnova (HEY1)

OriGene Purified Recombinant Human Proteins (see all 2): HEY1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for HEY1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HEY1
	Sigma-Aldrich Antibodies for HEY1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (HEY1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HEY1)
	Novus Biologicals Antibodies for HEY1

Assays for HEY1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9Y5J3

ProtoNet protein and cluster: Q9Y5J3

2 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB003650 Orange

UniProtKB/Swiss-Prot: HEY1_HUMAN, Q9Y5J3

Similarity: Belongs to the HEY family

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 Orange domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HEY1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HEY1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001040708

Applied Biosystems Silencer® siRNAs for HEY1

Sigma-Aldrich siRNA for HEY1

Sigma-Aldrich shRNA for HEY1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HEY1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001040708
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001040708
untagged cDNA clones in CMV expression vector (see all 2): NM_001040708

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001040708

UniProtKB/Swiss-Prot: HEY1_HUMAN, Q9Y5J3

Function: Downstream effector of Notch signaling which may be required for cardiovascular

development. Transcriptional repressor which binds preferentially to the canonical E box sequence

5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6

10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hey1):

	craniofacial	embryogenesis	growth/size	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	muscle	nervous system	normal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	10415358
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for HEY1 (Your Favorite Gene powered by Ingenuity)

Notch Signaling

GeneDecks HEY1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for HEY1

5/28 Interacting proteins for HEY1 (ENSP00000338272³ Q9Y5J3²) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LAPTM5	Q13571²	MINT-62172
PRKD2	Q9BZL6²	MINT-61765
SKIL	P12757²	MINT-61692
SMAD3	P84022²	MINT-61736
SMAD9	O15198²	MINT-61941

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001570	vasculogenesis	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007219	Notch signaling pathway	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007399	nervous system development	TAS	10415358

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HEY1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HEY1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HEY1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001040708

Sigma-Aldrich siRNA for HEY1

Sigma-Aldrich shRNA for HEY1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001040708 NM_012258

REFSEQ mRNAs for HEY1 gene (2 alternative transcripts):

NM_001040708.1 NM_012258.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001040708 NM_012258

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001040708
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001040708
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001040708

Additional cDNA sequence:

AF151522.1 AF176422.1 AF232239.1 AF254637.1 AF311883.1 AJ272214.1 AK074641.1 AK226041.1

AK293646.1 AK307622.1 AK313271.1 BC001873.1 BT020065.1 CR598609.1 CR607416.1 CR622924.1

8 DOTS entries:

DT.453681 DT.100755163 DT.100755165 DT.100755167 DT.100755164 DT.121474397 DT.121474401 DT.121474406

24/133 AceView cDNA sequences (see all 133 ):

AF151522 AI361962 CR607416 BI491971 AJ272214 AA664017 H41457 CB153638

AL520694 CR622924 CB044126 BC001873 BX279954 AF311883 BU737949 AI302724

CR598609 AA974813 AL528481 BI916292 BQ893783 BQ439301 BF062158 AI078800

highest scoring ESTs for HEY1:

AF151522 AF176422 AF232239 AF254637 AF311883 AI272343 AI829517 AJ272214 AK074641 AL544498

Unigene Cluster for HEY1:

Hairy/enhancer-of-split related with YRPW motif 1

Hs.234434 [show with all ESTs]

Unigene Representative Sequence: NM_001040708

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HEY1

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	·	6d
SP1:							-						-		-				-
SP2:							-								-				-
SP3:													-		-				-
SP4:							-
SP5:

About this scheme

ECgene alternative splicing isoforms for HEY1

2 Ensembl transcripts including schematic representations:

ENST00000337919 ENST00000354724

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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HEY1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HEY1

¹ / ² / ³

7 probe-sets matching HEY1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43989_at²^{, 3}	U95-B	1	1.00	1.00	0.96	0.93	AI829517	0.80	1.00	0.91	1
60272_at²^{, 3}	U95-C	1	1.00	1.00	0.88	0.80	X84714	0.60	1.00	0.82	1
44783_s_at²^{, 3}	U133-B	1	1.00	1.00	0.93	1.29	R61374	0.80	1.00	0.91	1
218839_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012258	0.60	1.00	0.82	1
44783_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	R61374	0.80	1.00	0.91	1
218839_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
44783_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HEY1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAACTGTGGT

SOURCE GeneReport for Unigene cluster: Hs.234434
UniProtKB/Swiss-Prot: HEY1_HUMAN, Q9Y5J3
Tissue specificity: Expressed in the somitic mesoderm, the central nervous system, the kidney, the
heart, nasal epithelium, and limbs

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HEY1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HEY1¹	--	hairy/enhancer-of-split related with YRPW motif 1	90.57(n) 95.72(a)	403420 NM_001002953.1 NP_001002953.1
chimpanzee (Pan troglodytes)	HEY1¹	--	hairy/enhancer-of-split related with YRPW motif 1	100(n) 100(a)	464248 XM_519823.2 XP_519823.2
cow (Bos taurus)	HEY1¹	--	hairy/enhancer-of-split related with YRPW motif 1	91.78(n) 95.39(a)	408005 NM_001001172.2 NP_001001172.2
rat (Rattus norvegicus)	Hey1¹	--	hairy/enhancer-of-split related with YRPW motif 1	86.42(n) 91.1(a)	155437 XM_342216.3 XP_342217.3
mouse (Mus musculus)	Hey1^{1, 5}	3 (2.40 cM)⁵	hairy/enhancer-of-split related with YRPW motif 1^{1, 5}	90.64(n)¹ 96.32(a)¹	15213¹ NM_010423.2¹ NP_034553.2¹ AB041590⁵ AF151521⁵ (see all 15)

About this table Species with no ortholog for HEY1

ENSEMBL Gene Tree for HEY1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HEY1 gene

HEYL² HELT² HEY2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/36 NCBI SNPs in HEY1 are shown (see all 36 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 31)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1046472^1,2	C,F,H,O	80839084(-)	`TGGAAA/CCTGTT`	2	--	ut3¹		16		MN EA NA EU WA	2918
--	rs2979713^1,2	A,C	80844344(+)	`gtagaA/Gacgag`	2	--	ng3¹		0	--	--	--	--
	rs2467789^1,2	A,C	80839819(+)	`AAAGAA/TAAAAG`	2	--	ut3¹		0	--	--	--	--
--	rs11553421^1,2	H	80841492(-)	`AGATCC/ATGCAG`	2	M/L	mis¹ ese³		4		EU EA WA	350
	rs3763532^1,2	H	80844163(+)	`GCTAtT/Cttttt`	2	--	ng3¹ trp³		1		EU	118
	rs960978^1,2	A,C,F,H	80841420(+)	`GCCCCC/AACTAG`	2	--	int¹		14		NS EU EA WA NA	970
--	rs61407123^1,2	--	80844162(+)	`GCTAT-/CTTTTTTTT TTTTTTTTTTTTTTTTT`	2	--	ng3¹		0	--	--	--	--
--	rs61753715^1,2	--	80840082(+)	`GTGGAA/GGGAGC`	2	F/L	mis¹		0	--	--	--	--
	rs1062358^1,2	--	80839733(-)	`ATTGAA/GATAGT`	2	--	ut3¹		1		MN	184
--	rs35881291^1,2	--	80842733(+)	`CGCCGA/CTGATT`	2	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for HEY1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602953

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/30 PubMed articles for HEY1 gene (see all 30 ):

Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. (PubMed id 10403790)^{2, 3, 4} Kokubo H....Johnson R.L. (1999)
Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis. (PubMed id 10415358)^{2, 3, 4} Leimeister C.... Gessler M. (1999)
Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. (PubMed id 10860664)^{1, 3, 4} Steidl C....Gessler M. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. (PubMed id 11095750)^{3, 4} Nakagawa O.... Olson E.N. (2000)
Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. (PubMed id 10692439)^{3, 4} Chin M.T.... Lee M.-E. (2000)
HERP, a new primary target of Notch regulated by ligand binding. (PubMed id 11486044)^{1, 3} Iso T.... Hamamori Y. (2001)
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. (PubMed id 18986983)³ Sharff K.A....He T.C. (2009)
Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. (PubMed id 18239137)³ Tang Y....Liaw L. (2008)
Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. (PubMed id 17496152)³ Hardie W.D....Leikauf G.D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 23462	HGNC: 4880	AceView: HEY1	Ensembl:ENSG00000164683	euGenes: HUgn23462
ECgene: HEY1	H-InvDB: HEY1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for HEY1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HEY1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HEY1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HEY1		Antibodies for HEY1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HEY1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Search Tocris compounds for HEY1

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HEY1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for HEY1

Summaries
for HEY1

Genomic Location
for HEY1

Proteins
for HEY1

Protein Domains/
Families
for HEY1

Gene Function
for HEY1

Pathways & Interactions
for HEY1

Drugs & Compounds
for HEY1

Transcripts
for HEY1

Expression
for HEY1

Orthologs
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Disorders & Mutations
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Services
for HEY1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HEY1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor HEY1

Summariesfor HEY1

Genomic Locationfor HEY1

Proteinsfor HEY1

Protein Domains/Familiesfor HEY1

Gene Functionfor HEY1

Pathways & Interactionsfor HEY1

Drugs & Compoundsfor HEY1

Transcriptsfor HEY1

Expression for HEY1

Orthologsfor HEY1

Paralogsfor HEY1

SNPs/Variantsfor HEY1

Disorders & Mutationsfor HEY1

Medical Newsfor HEY1

Publicationsfor HEY1

Search for HEY1

Genome Databases showing HEY1

Other Databases showing HEY1

Specialized Databases showing HEY1

Licensable Technologiesfor HEY1

Servicesfor HEY1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HEY1

Summaries
for HEY1

Genomic Location
for HEY1

Proteins
for HEY1

Protein Domains/
Families
for HEY1

Gene Function
for HEY1

Pathways & Interactions
for HEY1

Drugs & Compounds
for HEY1

Transcripts
for HEY1

Expression
for HEY1

Orthologs
for HEY1

Paralogs
for HEY1

SNPs/Variants
for HEY1

Disorders & Mutations
for HEY1

Medical News
for HEY1

Publications
for HEY1

Licensable Technologies
for HEY1

Services
for HEY1