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Aliases for HEXIM2 Gene

Aliases for HEXIM2 Gene

  • Hexamethylene Bis-Acetamide Inducible 2 2 3
  • Hexamethylene Bis-Acetamide-Inducible Protein 2 3 4
  • Hexamethylene-Bis-Acetamide-Inducible Transcript 2 3
  • Protein HEXIM2 3
  • MAQ1 Paralog 3
  • L3 3

External Ids for HEXIM2 Gene

Previous GeneCards Identifiers for HEXIM2 Gene

  • GC17P040595
  • GC17P043238
  • GC17P039001

Summaries for HEXIM2 Gene

Entrez Gene Summary for HEXIM2 Gene

  • This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for HEXIM2 Gene

HEXIM2 (Hexamethylene Bis-Acetamide Inducible 2) is a Protein Coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM1.

UniProtKB/Swiss-Prot for HEXIM2 Gene

  • Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

Gene Wiki entry for HEXIM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEXIM2 Gene

Genomics for HEXIM2 Gene

Regulatory Elements for HEXIM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HEXIM2 Gene

Start:
45,159,335 bp from pter
End:
45,170,040 bp from pter
Size:
10,706 bases
Orientation:
Plus strand

Genomic View for HEXIM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEXIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEXIM2 Gene

Proteins for HEXIM2 Gene

  • Protein details for HEXIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MH2-HEXI2_HUMAN
    Recommended name:
    Protein HEXIM2
    Protein Accession:
    Q96MH2
    Secondary Accessions:
    • D3DX66

    Protein attributes for HEXIM2 Gene

    Size:
    286 amino acids
    Molecular mass:
    32419 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.

neXtProt entry for HEXIM2 Gene

Proteomics data for HEXIM2 Gene at MOPED

Post-translational modifications for HEXIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for HEXIM2 Gene

Domains for HEXIM2 Gene

Protein Domains for HEXIM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HEXIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MH2

UniProtKB/Swiss-Prot:

HEXI2_HUMAN :
  • Q96MH2
Domain:
  • The coiled-coil domain mediates oligomerization
Family:
  • Belongs to the HEXIM family.
genes like me logo Genes that share domains with HEXIM2: view

No data available for Gene Families for HEXIM2 Gene

Function for HEXIM2 Gene

Molecular function for HEXIM2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
UniProtKB/Swiss-Prot Induction: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).

Gene Ontology (GO) - Molecular Function for HEXIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 15713662
GO:0005515 protein binding IPI 15713661
GO:0017069 snRNA binding IDA 15713662
genes like me logo Genes that share ontologies with HEXIM2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HEXIM2 Gene

Localization for HEXIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEXIM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEXIM2 Gene COMPARTMENTS Subcellular localization image for HEXIM2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for HEXIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with HEXIM2: view

Pathways for HEXIM2 Gene

SuperPathways for HEXIM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HEXIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15713662
GO:0006351 transcription, DNA-templated IEA --
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA 15713662
GO:0045892 negative regulation of transcription, DNA-templated IDA 15713662
GO:0071901 negative regulation of protein serine/threonine kinase activity --
genes like me logo Genes that share ontologies with HEXIM2: view

No data available for Pathways by source for HEXIM2 Gene

Transcripts for HEXIM2 Gene

Unigene Clusters for HEXIM2 Gene

Hexamethylene bis-acetamide inducible 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEXIM2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HEXIM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEXIM2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: - - - - - - -
SP2:
SP3: -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - -
SP8: -

Relevant External Links for HEXIM2 Gene

GeneLoc Exon Structure for
HEXIM2
ECgene alternative splicing isoforms for
HEXIM2

Expression for HEXIM2 Gene

mRNA expression in normal human tissues for HEXIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEXIM2 Gene

This gene is overexpressed in Muscle - Skeletal (6.1) and Testis (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEXIM2 Gene

SOURCE GeneReport for Unigene cluster for HEXIM2 Gene Hs.56382

mRNA Expression by UniProt/SwissProt for HEXIM2 Gene

Q96MH2-HEXI2_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
genes like me logo Genes that share expressions with HEXIM2: view

In Situ Assay Products

Orthologs for HEXIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEXIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEXIM2 35
  • 99.88 (n)
  • 100 (a)
HEXIM2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HEXIM2 35
  • 84.64 (n)
  • 82.86 (a)
HEXIM2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEXIM2 35
  • 85.73 (n)
  • 83.8 (a)
HEXIM2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hexim2 35
  • 81.8 (n)
  • 78.01 (a)
Hexim2 16
Hexim2 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HEXIM2 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hexim2 35
  • 82.39 (n)
  • 77.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for HEXIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HEXIM2 Gene

ENSEMBL:
Gene Tree for HEXIM2 (if available)
TreeFam:
Gene Tree for HEXIM2 (if available)

Paralogs for HEXIM2 Gene

Paralogs for HEXIM2 Gene

Selected SIMAP similar genes for HEXIM2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HEXIM2: view

Variants for HEXIM2 Gene

Sequence variations from dbSNP and Humsavar for HEXIM2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1105858 -- 45,161,912(-) TCTGG(G/T)CAAGC intron-variant, utr-variant-5-prime
rs4383190 -- 45,161,308(-) CTCAA(A/G/T)CCGTC intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs4627401 -- 45,166,667(-) cctaa(A/T)gtaga intron-variant
rs4792858 -- 45,167,333(+) ACACA(A/C)AAAAA intron-variant
rs6503425 -- 45,164,593(+) gatca(C/T)gccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEXIM2 Gene

Variant ID Type Subtype PubMed ID
nsv527788 CNV Loss 19592680
nsv908297 CNV Loss 21882294
dgv3179n71 CNV Loss 21882294
nsv908300 CNV Loss 21882294
nsv2062 CNV Insertion 18451855
esv994531 CNV Deletion 20482838

Relevant External Links for HEXIM2 Gene

HapMap Linkage Disequilibrium report
HEXIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEXIM2 Gene

Disorders for HEXIM2 Gene

Relevant External Links for HEXIM2

Genetic Association Database (GAD)
HEXIM2
genes like me logo Genes that share disorders with HEXIM2: view

No data available for UniProtKB/Swiss-Prot for HEXIM2 Gene

Publications for HEXIM2 Gene

  1. Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. (PMID: 15713661) Yik J.H.N. … Zhou Q. (J. Biol. Chem. 2005) 3 4 23
  2. HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. (PMID: 15713662) Byers S.A. … Price D.H. (J. Biol. Chem. 2005) 3 4 23
  3. Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. (PMID: 15965233) Li Q. … Price D.H. (J. Biol. Chem. 2005) 3 23
  4. The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes. (PMID: 17709395) Barrandon C. … Bensaude O. (Mol. Cell. Biol. 2007) 3 23
  5. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. (PMID: 12832472) Michels A.A. … Bensaude O. (Mol. Cell. Biol. 2003) 2 3

Products for HEXIM2 Gene

Sources for HEXIM2 Gene

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