Aliases for HEXIM2 Gene
Aliases for HEXIM2 Gene
External Ids for HEXIM2 Gene
- HGNC: 28591
- Entrez Gene: 124790
- Ensembl: ENSG00000168517
- OMIM: 615695
- UniProtKB: Q96MH2
Previous GeneCards Identifiers for HEXIM2 Gene
- GC17P040595
- GC17P043238
- GC17P039001
Summaries for HEXIM2 Gene
-
This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for HEXIM2 Gene
HEXIM2 (Hexamethylene Bisacetamide Inducible 2) is a Protein Coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM1.
UniProtKB/Swiss-Prot for HEXIM2 Gene
-
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEXIM2 Gene
Genomics for HEXIM2 Gene
Regulatory Elements for HEXIM2 Gene
- Transcription factor binding sites by QIAGEN in the HEXIM2 gene promoter:
Regulatory Element Products
Genomic Location for HEXIM2 Gene
- Chromosome:
- 17
- Start:
- 45,160,026 bp from pter
- End:
- 45,170,040 bp from pter
- Size:
- 10,015 bases
- Orientation:
- Plus strand
Genomic View for HEXIM2 Gene
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HEXIM2 Gene
Proteins for HEXIM2 Gene
-
Protein details for HEXIM2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96MH2-HEXI2_HUMAN
- Recommended name:
- Protein HEXIM2
- Protein Accession:
- Q96MH2
- D3DX66
Protein attributes for HEXIM2 Gene
- Size:
- 286 amino acids
- Molecular mass:
- 32419 Da
- Quaternary structure:
-
- Homooligomer and heterooligomer with HEXIM1; probably dimeric (PubMed:15713661, PubMed:15994294). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:15713661, PubMed:15713662, PubMed:15994294). Interacts with CCNT2 (PubMed:19883659).
Protein Expression for HEXIM2 Gene
Post-translational modifications for HEXIM2 Gene
Other Protein References for HEXIM2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HEXIM2
-
Custom Antibody ServicesOriGene Antibodies for HEXIM2
- Novus Biologicals Antibodies for HEXIM2
-
Abcam antibodies for HEXIM2
- Invitrogen Antibodies for HEXIM2
- antibodies-online Antibodies for HEXIM2: See all 24
- GeneTex HEXIM2 antibody for HEXIM2
-
Santa Cruz Biotechnology (SCBT) Antibodies for HEXIM2
Protein Products
-
OriGene Purified Proteins for HEXIM2
- Search Origene for MassSpec and Protein Over-expression Lysates for HEXIM2
- Origene Custom Protein Services for HEXIM2
- antibodies-online Proteins for HEXIM2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HEXIM2
Assay Products
- antibodies-online Kits for HEXIM2: See all 3
No data available for DME Specific Peptides for HEXIM2 Gene
Domains & Families for HEXIM2 Gene
Suggested Antigen Peptide Sequences for HEXIM2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96MH2UniProtKB/Swiss-Prot:
HEXI2_HUMAN :- The coiled-coil domain mediates oligomerization.
- Belongs to the HEXIM family.
- Domain:
-
- The coiled-coil domain mediates oligomerization.
- Family:
-
- Belongs to the HEXIM family.
No data available for Gene Families for HEXIM2 Gene
Function for HEXIM2 Gene
Molecular function for HEXIM2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | IDA | 15713662 |
| GO:0005515 | protein binding | IPI | 15713661 |
| GO:0017069 | snRNA binding | IDA | 15713662 |
| GO:0042802 | identical protein binding | IPI | 21516116 |
| GO:0097322 | 7SK snRNA binding | IDA | 19883659 |
Phenotypes for HEXIM2 Gene
- GenomeRNAi human phenotypes for HEXIM2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HEXIM2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEXIM2 gene
- Search ViGene Biosciences for HEXIM2
CRISPR Products
-
OriGene CRISPR knockouts for HEXIM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEXIM2
- GenScript: Design CRISPR guide RNA sequences for HEXIM2
miRNA Products
- Search ViGene Biosciences for HEXIM2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HEXIM2
- Browse OriGene Inhibitory RNA Products For HEXIM2
-
ViGene Biosciences ready-to-package AAV shRNAs for HEXIM2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HEXIM2
Cell Line Products
-
Horizon Cell Lines for HEXIM2
-
ViGene Biosciences adenoviral particle packaged cDNA for HEXIM2 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEXIM2 Gene
Localization for HEXIM2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HEXIM2 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016607 | nuclear speck | IDA | -- |
Pathways & Interactions for HEXIM2 Gene
Interacting Proteins for HEXIM2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 15713662 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | IDA | 15713662 |
| GO:0045892 | negative regulation of transcription, DNA-templated | IDA | 15713662 |
No data available for Pathways by source and SIGNOR curated interactions for HEXIM2 Gene
Transcripts for HEXIM2 Gene
mRNA/cDNA for HEXIM2 Gene
- (18) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (62) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HEXIM2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HEXIM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEXIM2
- GenScript: Design CRISPR guide RNA sequences for HEXIM2
miRNA Products
- Search ViGene Biosciences for HEXIM2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HEXIM2
- Browse OriGene Inhibitory RNA Products For HEXIM2
-
ViGene Biosciences ready-to-package AAV shRNAs for HEXIM2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HEXIM2
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for HEXIM2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for HEXIM2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HEXIM2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HEXIM2 Gene:
HEXIM2SOURCE GeneReport for Unigene cluster for HEXIM2 Gene:
Hs.56382mRNA Expression by UniProt/SwissProt for HEXIM2 Gene:
Q96MH2-HEXI2_HUMANEvidence on tissue expression from TISSUES for HEXIM2 Gene
- Muscle(4.2)
- Eye(4.1)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for HEXIM2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HEXIM2 Gene
Orthologs for HEXIM2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HEXIM2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HEXIM2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HEXIM2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hexim2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hexim2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HEXIM2 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HEXIM2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HEXIM2 Gene
(1) SIMAP similar genes for HEXIM2 Gene using alignment to 6 proteins:
Variants for HEXIM2 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000098491 | -- | 45,166,562(+) | GATGC(A/G)TTCTC | intron-variant | |
| rs1000746769 | -- | 45,160,748(+) | AGGTT(A/G)TCCGG | upstream-variant-2KB, utr-variant-5-prime | |
| rs1000918152 | -- | 45,161,505(+) | ATGGC(A/G)GCGAT | intron-variant, upstream-variant-2KB | |
| rs1000975087 | -- | 45,161,599(+) | TTCTG(C/T)CCCGT | intron-variant, upstream-variant-2KB | |
| rs1001397804 | -- | 45,166,369(+) | CAATC(C/T)ACCCT | intron-variant |
Relevant External Links for HEXIM2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HEXIM2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEXIM2 Gene
Disorders for HEXIM2 Gene
Relevant External Links for HEXIM2
No disorders were found for HEXIM2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEXIM2 Gene
Publications for HEXIM2 Gene
- Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. (PMID: 15713661) Yik J.H.N. … Zhou Q. (J. Biol. Chem. 2005) 3 4 22 64
- HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. (PMID: 15713662) Byers S.A. … Price D.H. (J. Biol. Chem. 2005) 3 4 22 64
- Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA. (PMID: 19883659) Czudnochowski N. … Geyer M. (J. Mol. Biol. 2010) 3 4 64
- Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 46 64
- The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes. (PMID: 17709395) Barrandon C. … Bensaude O. (Mol. Cell. Biol. 2007) 3 22 64
Products for HEXIM2 Gene
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- Custom Antibody ServicesOriGene Antibodies for HEXIM2
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- OriGene Purified Proteins for HEXIM2
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- Novus Biologicals Antibodies for HEXIM2
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for HEXIM2
- antibodies-online Antibodies for HEXIM2: See all 24
- antibodies-online Kits for HEXIM2: See all 3
- antibodies-online Proteins for HEXIM2: See all 5
- Search antibodies-online for peptides
- GeneTex HEXIM2 antibody for HEXIM2
- Search GeneTex for Proteins for HEXIM2
- ViGene Biosciences adenoviral particle packaged cDNA for HEXIM2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HEXIM2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HEXIM2 gene
- Search ViGene Biosciences for HEXIM2
- Santa Cruz Biotechnology (SCBT) Antibodies for HEXIM2
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- Santa Cruz Biotechnology (SCBT) CRISPR for HEXIM2
- Horizon Cell Lines for HEXIM2
- Cyagen custom Knockout/knockin (KOKI) mouse models for HEXIM2
- VectorBuilder custom plasmid, inducible vectors for HEXIM2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HEXIM2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




