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HEXIM2 Gene

protein-coding   GIFtS: 50
GCID: GC17P043238

Hexamethylene Bis-Acetamide Inducible 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hexamethylene Bis-Acetamide Inducible 21 2
Hexamethylene Bis-Acetamide-Inducible Protein 22 3
Hexamethylene-Bis-Acetamide-Inducible Transcript 22
Hexamthylene Bis-Acetamide Inducible 22
MAQ1 Paralog2
Protein HEXIM22

External Ids:    HGNC: 285911   Entrez Gene: 1247902   Ensembl: ENSG000001685177   OMIM: 6156955   UniProtKB: Q96MH23   

Export aliases for HEXIM2 gene to outside databases

Previous GC identifers: GC17P040595 GC17P039001


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HEXIM2 Gene:
HEXIM2 (hexamethylene bis-acetamide inducible 2) is a protein-coding gene. Diseases associated with HEXIM2 include tonsillitis, and hiv-1. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM1.

UniProtKB/Swiss-Prot: HEXI2_HUMAN, Q96MH2
Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In
cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II
phosphorylation and subsequent transcriptional elongation

Gene Wiki entry for HEXIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HEXIM2 gene promoter:
         E2F-3a   E2F-4   E2F-5   RREB-1   E2F-2   Nkx2-5   Evi-1   C/EBPalpha   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HEXIM2 promoter sequence
   Search Chromatin IP Primers for HEXIM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HEXIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

HEXIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEXIM2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P043238:  view genomic region     (about GC identifiers)

Start:
43,238,067 bp from pter      End:
43,247,407 bp from pter
Size:
9,341 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HEXI2_HUMAN, Q96MH2 (See protein sequence)
Recommended Name: Protein HEXIM2  
Size: 286 amino acids; 32419 Da
Subunit: Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at
least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK
and U6 snRNAs
Secondary accessions: D3DX66

Explore the universe of human proteins at neXtProt for HEXIM2: NX_Q96MH2

Explore proteomics data for HEXIM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HEXIM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653209.1  
    ENSEMBL proteins: 
     ENSP00000302276   ENSP00000468251   ENSP00000468773   ENSP00000465086   ENSP00000466200  
     ENSP00000465727   ENSP00000464807   ENSP00000467517  

    HEXIM2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for HEXIM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR024872 HEXIM
     IPR024876 HEXIM2

    Graphical View of Domain Structure for InterPro Entry Q96MH2

    ProtoNet protein and cluster: Q96MH2

    UniProtKB/Swiss-Prot: HEXI2_HUMAN, Q96MH2
    Domain: The coiled-coil domain mediates oligomerization
    Similarity: Belongs to the HEXIM family


    HEXIM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HEXI2_HUMAN, Q96MH2
    Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In
    cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II
    phosphorylation and subsequent transcriptional elongation
    Induction: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity IDA15713662
    GO:0005515protein binding IPI15713661
    GO:0017069snRNA binding IDA15713662
         
    HEXIM2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HEXIM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HEXIM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HEXIM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HEXIM2

    miRNA
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    Block miRNA regulation of human, mouse, rat HEXIM2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HEXIM2:
    hsa-miR-1266 hsa-miR-452*
    SwitchGear 3'UTR luciferase reporter plasmidHEXIM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HEXIM2
    Predesigned siRNA for gene silencing in human, mouse, rat HEXIM2

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    GenScript: all cDNA clones in your preferred vector: HEXIM2 (NM_144608)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEXIM2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEXIM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HEXI2_HUMAN, Q96MH2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    HEXIM2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HEXIM2
    Interactions:

        GeneGlobe Interaction Network for HEXIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for HEXIM2 (Q96MH23 ENSP000003022764) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNT1O605633, ENSP000002619004I2D: score=1 STRING: ENSP00000261900
    CDK9P507503, ENSP000003623614I2D: score=2 STRING: ENSP00000362361
    MEPCEQ7L2J03I2D: score=1 
    PRDM14Q9GZV83I2D: score=1 
    TCF12Q990813I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15713662
    GO:0006351transcription, DNA-templated IEA--
    GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA15713662
    GO:0045892negative regulation of transcription, DNA-templated IDA15713662

    HEXIM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HEXIM2 (HEXI2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HEXIM2 gene: 
    NM_144608.1  

    Unigene Cluster for HEXIM2:

    Hexamethylene bis-acetamide inducible 2
    Hs.56382  [show with all ESTs]
    Unigene Representative Sequence: AK056946
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307275(uc002iih.1 uc010daf.1 uc002iii.1 uc002iij.1)
    ENST00000585340 ENST00000593138 ENST00000586681 ENST00000589230 ENST00000591576
    ENST00000591070 ENST00000592695
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HEXIM2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HEXIM2:
    hsa-miR-1266 hsa-miR-452*
    SwitchGear 3'UTR luciferase reporter plasmidHEXIM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HEXIM2
    Predesigned siRNA for gene silencing in human, mouse, rat HEXIM2
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    OriGene clones in human, mouse for HEXIM2 (see all 9)
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    GenScript: all cDNA clones in your preferred vector: HEXIM2 (NM_144608)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEXIM2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HEXIM2
      QuantiTect SYBR Green Assays in human, mouse, rat HEXIM2
      QuantiFast Probe-based Assays in human, mouse, rat HEXIM2

    Additional mRNA sequence: 

    AK056946.1 AY598322.1 BC003531.1 BC012474.1 BC025970.1 

    9 DOTS entries:

    DT.101983448  DT.203200  DT.452137  DT.97841402  DT.100808733  DT.95362323  DT.97763021  DT.102836051 
    DT.99938769 

    Selected AceView cDNA sequences (see all 62):

    NM_144608 BI830796 AY598322 BM711252 AA860896 AI094640 CA312625 BU729862 
    BC025970 CA311712 BM702930 CD676231 BC003531 CA312679 AK056946 BC012474 
    BQ065045 BE378691 BU501076 BX453824 BE746438 BE384953 T08565 CF528783 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HEXIM2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
    SP1:              -     -     -     -     -     -     -                                                               
    SP2:                                                                                                                  
    SP3:                                                  -                                                               
    SP4:              -     -     -     -     -     -     -     -                                                         
    SP5:                          -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for HEXIM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HEXIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATCTCCCA
    HEXIM2 Expression
    About this image


    HEXIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    HEXIM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HEXIM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.56382

    UniProtKB/Swiss-Prot: HEXI2_HUMAN, Q96MH2
    Tissue specificity: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially
    expressed

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for HEXIM2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hexim21 , 5 hexamethylene bis-acetamide inducible 21, 5 81.8(n)1
    78.01(a)1
      11 (66.71 cM)5
    710591  NM_027658.21  NP_081934.11 
     1031324295 


    ENSEMBL Gene Tree for HEXIM2 (if available)
    TreeFam Gene Tree for HEXIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HEXIM2 gene
    HEXIM12  
    1 SIMAP similar gene for HEXIM2 using alignment to 6 protein entries:     HEXI2_HUMAN (see all proteins):
    HEXIM1

    HEXIM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HEXIM2 (see all 223)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469869981,2
    C--43236309(+) TTTCAC/TCATGT 1 -- us2k10--------
    rs1923918911,2
    --43236435(+) AAGAAG/TGGAAA 1 -- us2k10--------
    rs1476069131,2
    C--43236663(+) TTTAAG/TTCCTA 1 -- us2k10--------
    rs1832913181,2
    C--43236704(+) CTCTTC/GATCAG 1 -- us2k10--------
    rs1423028691,2
    C--43236731(+) CATATC/GTAGGT 1 -- us2k10--------
    rs1142255771,2
    C,F--43236794(+) AAGTGG/TTTCCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1879205451,2
    --43236882(+) AAAAGC/TTAATG 1 -- us2k10--------
    rs1926413301,2
    --43236905(+) CACTCC/TAACTG 1 -- us2k10--------
    rs360781751,2
    C--43236970(+) TTTTTT/-GAGAC 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1844577611,2
    --43236991(+) TCTGTC/GACCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HEXIM2 (43238067 - 43247407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HEXIM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv994531CNV Deletion20482838
    nsv2062CNV Insertion18451855
    nsv527788CNV Loss19592680
    nsv908300CNV Loss21882294
    nsv908297CNV Loss21882294
    dgv3179n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HEXIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for HEXIM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615695    OMIM disorders: --

    5 diseases for HEXIM2:    
    About MalaCards
    tonsillitis    hiv-1    lung cancer    cerebritis
    thyroiditis


    HEXIM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HEXIM2

    Export disorders for HEXIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HEXIM2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with HEXIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. (PubMed id 15713662)1, 2, 9 Byers S.A.... Price D.H. (J. Biol. Chem. 2005)
    2. Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. (PubMed id 15713661)1, 2, 9 Yik J.H.N.... Zhou Q. (J. Biol. Chem. 2005)
    3. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)
    4. Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer. (PubMed id 15994294)1, 2 Dulac C.... Bensaude O. (J. Biol. Chem. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (Oncogene 2004)
    7. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. (PubMed id 12832472)1, 3 Michels A.A.... Bensaude O. (Mol. Cell. Biol. 2003)
    8. Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. (PubMed id 15965233)1, 9 Li Q.... Price D.H. (J. Biol. Chem. 2005)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124790 HGNC: 28591 AceView: FLJ32384 Ensembl:ENSG00000168517 euGenes: HUgn124790
    ECgene: HEXIM2 H-InvDB: HEXIM2

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HEXIM2 Pharmacogenomics, SNPs, Pathways

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