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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HEXIM2 Gene

protein-coding   GIFtS: 50
GCID: GC17P043238

Hexamethylene Bis-Acetamide Inducible 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hexamethylene Bis-Acetamide Inducible 21 2
Hexamethylene Bis-Acetamide-Inducible Protein 22 3
Hexamethylene-Bis-Acetamide-Inducible Transcript 22
Hexamthylene Bis-Acetamide Inducible 22
MAQ1 Paralog2
Protein HEXIM22

External Ids:    HGNC: 285911   Entrez Gene: 1247902   Ensembl: ENSG000001685177   UniProtKB: Q96MH23   

Export aliases for HEXIM2 gene to outside databases

Previous GC identifers: GC17P040595 GC17P039001


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HEXIM2 Gene: 
HEXIM2 (hexamethylene bis-acetamide inducible 2) is a protein-coding gene. Diseases associated with HEXIM2 include lung cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM1.

UniProtKB/Swiss-Prot: HEXI2_HUMAN, Q96MH2
Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In
cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II
phosphorylation and subsequent transcriptional elongation

Gene Wiki entry for HEXIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HEXIM2 gene promoter:
         E2F-3a   E2F-4   E2F-5   RREB-1   E2F-2   Nkx2-5   Evi-1   C/EBPalpha   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HEXIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HEXIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEXIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

HEXIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEXIM2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P043238:  view genomic region     (about GC identifiers)

Start:
43,238,067 bp from pter      End:
43,247,407 bp from pter
Size:
9,341 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HEXI2_HUMAN, Q96MH2 (See protein sequence)
Recommended Name: Protein HEXIM2  
Size: 286 amino acids; 32419 Da
Subunit: Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at
least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK
and U6 snRNAs
Subcellular location: Nucleus
Secondary accessions: D3DX66

Explore the universe of human proteins at neXtProt for HEXIM2: NX_Q96MH2

Explore proteomics data for HEXIM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96MH2

  • HEXIM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HEXIM2 Protein Expression
    REFSEQ proteins: NP_653209.1  
    ENSEMBL proteins: 
     ENSP00000302276   ENSP00000468251   ENSP00000468773   ENSP00000465086   ENSP00000466200  
     ENSP00000465727   ENSP00000464807   ENSP00000467517  

    Human Recombinant Protein Products for HEXIM2: 
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    Novus Biologicals HEXIM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HEXIM2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--

    HEXIM2 for ontologies           About GeneDecksing



    HEXIM2 Antibody Products: 
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    Assay Products for HEXIM2: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HEXIM2 
    Cloud-Clone Corp. CLIAs for HEXIM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR024872 HEXIM
     IPR024876 HEXIM2

    Graphical View of Domain Structure for InterPro Entry Q96MH2

    ProtoNet protein and cluster: Q96MH2

    UniProtKB/Swiss-Prot: HEXI2_HUMAN, Q96MH2
    Domain: The coiled-coil domain mediates oligomerization
    Similarity: Belongs to the HEXIM family


    HEXIM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HEXI2_HUMAN, Q96MH2
    Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In
    cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II
    phosphorylation and subsequent transcriptional elongation
    Induction: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity IDA15713662
    GO:0005515protein binding IPI15713661
    GO:0017069snRNA binding IDA15713662
         
    HEXIM2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HEXIM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HEXIM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HEXIM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HEXIM2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEXIM2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HEXIM2:
    hsa-miR-1266 hsa-miR-452*
    SwitchGear 3'UTR luciferase reporter plasmidHEXIM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HEXIM2
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of HEXIM2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HEXIM2 (see all 10)
    OriGene ORF clones in mouse, rat for HEXIM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HEXIM2 (NM_144608)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEXIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEXIM2
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                         Customized lentivirus expression plasmids for stable overexpression of HEXIM2 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEXIM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HEXIM2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for HEXIM2 (Q96MH23 ENSP000003022764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNT1O605633, ENSP000002619004I2D: score=1 STRING: ENSP00000261900
    CDK9P507503, ENSP000003623614I2D: score=2 STRING: ENSP00000362361
    MEPCEQ7L2J03I2D: score=1 
    PRDM14Q9GZV83I2D: score=1 
    TCF12Q990813I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15713662
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA15713662
    GO:0045892negative regulation of transcription, DNA-dependent IDA15713662

    HEXIM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HEXIM2 (HEXI2)

    Search CenterWatch for drugs/clinical trials and news about HEXIM2 / HEXI2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HEXIM2 gene: 
    NM_144608.1  

    Unigene Cluster for HEXIM2:

    Hexamethylene bis-acetamide inducible 2
    Hs.56382  [show with all ESTs]
    Unigene Representative Sequence: AK056946
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307275(uc002iih.1 uc010daf.1 uc002iii.1 uc002iij.1)
    ENST00000585340 ENST00000593138 ENST00000586681 ENST00000589230 ENST00000591576
    ENST00000591070 ENST00000592695
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEXIM2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HEXIM2:
    hsa-miR-1266 hsa-miR-452*
    SwitchGear 3'UTR luciferase reporter plasmidHEXIM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HEXIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEXIM2
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    GenScript: all cDNA clones in your preferred vector: HEXIM2 (NM_144608)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEXIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEXIM2
    Sirion Biotech Customized lentivirus for stable overexpression of HEXIM2 
                         Customized lentivirus expression plasmids for stable overexpression of HEXIM2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HEXIM2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEXIM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEXIM2

    Additional mRNA sequence: 

    AK056946.1 AY598322.1 BC003531.1 BC012474.1 BC025970.1 

    9 DOTS entries:

    DT.101983448  DT.203200  DT.452137  DT.97841402  DT.100808733  DT.95362323  DT.97763021  DT.102836051 
    DT.99938769 

    24/62 AceView cDNA sequences (see all 62):

    AK056946 BC003531 AY598322 CD676231 BC025970 CA312679 BC012474 CA312625 
    NM_144608 AI094640 BU729862 BI830796 BM702930 CA311712 BM711252 AA860896 
    BX453824 T08565 BQ065045 AI916639 BM662401 CB960762 BE746338 CF528783 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for HEXIM2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
    SP1:              -     -     -     -     -     -     -                                                               
    SP2:                                                                                                                  
    SP3:                                                  -                                                               
    SP4:              -     -     -     -     -     -     -     -                                                         
    SP5:                          -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for HEXIM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HEXIM2 expression in normal human tissues (normalized intensities)      HEXIM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATCTCCCA
    HEXIM2 Expression
    About this image


    HEXIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             platelets   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See HEXIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HEXIM2

    SOURCE GeneReport for Unigene cluster: Hs.56382

    UniProtKB/Swiss-Prot: HEXI2_HUMAN, Q96MH2
    Tissue specificity: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially
    expressed

        SABiosciences Custom PCR Arrays for HEXIM2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEXIM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEXIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HEXIM2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hexim21 , 5 hexamethylene bis-acetamide inducible 21, 5 81.8(n)1
    78.01(a)1
      11 (66.71 cM)5
    710591  NM_001130515.11  NP_001123987.11 
     1031324295 
    lizard
    (Anolis carolinensis)
    Reptilia HEXIM16
    Uncharacterized protein
    37(a)
    1 → many
    6(64978945-64979961)
    zebrafish
    (Danio rerio)
    Actinopterygii hexim16
    hexamethylene bis-acetamide inducible 1
    31(a)
    1 → many
    12(16412072-16413832)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35086
    --
    13(a)
    1 → many
    3R(10485163-10486899)


    ENSEMBL Gene Tree for HEXIM2 (if available)
    TreeFam Gene Tree for HEXIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HEXIM2 gene
    HEXIM12  
    1 SIMAP similar gene for HEXIM2 using alignment to 6 protein entries:     HEXI2_HUMAN (see all proteins):
    HEXIM1

    HEXIM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/223 SNPs in HEXIM2 are shown (see all 223)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469869981,2
    C--43236309(+) TTTCAC/TCATGT 1 -- us2k10--------
    rs1923918911,2
    --43236435(+) AAGAAG/TGGAAA 1 -- us2k10--------
    rs1476069131,2
    C--43236663(+) TTTAAG/TTCCTA 1 -- us2k10--------
    rs1832913181,2
    C--43236704(+) CTCTTC/GATCAG 1 -- us2k10--------
    rs1423028691,2
    C--43236731(+) CATATC/GTAGGT 1 -- us2k10--------
    rs1142255771,2
    C,F--43236794(+) AAGTGG/TTTCCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1879205451,2
    --43236882(+) AAAAGC/TTAATG 1 -- us2k10--------
    rs1926413301,2
    --43236905(+) CACTCC/TAACTG 1 -- us2k10--------
    rs360781751,2
    C--43236970(+) TTTTTT/-GAGAC 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1844577611,2
    --43236991(+) TCTGTC/GACCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HEXIM2 (43238067 - 43247407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HEXIM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv994531CNV Deletion20482838
    nsv2062CNV Insertion18451855
    nsv527788CNV Loss19592680
    nsv908300CNV Loss21882294
    nsv908297CNV Loss21882294
    dgv3179n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HEXIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for HEXIM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for HEXIM2:    About MalaCards
    lung cancer    


    HEXIM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HEXIM2

    Export disorders for HEXIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HEXIM2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with HEXIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. (PubMed id 15713662)1, 2, 9 Byers S.A.... Price D.H. (2005)
    2. Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. (PubMed id 15713661)1, 2, 9 Yik J.H.N.... Zhou Q. (2005)
    3. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (2009)
    4. Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer. (PubMed id 15994294)1, 2 Dulac C.... Bensaude O. (2005)
    5. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. (PubMed id 12832472)1, 3 Michels A.A....Bensaude O. (2003)
    8. Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. (PubMed id 15965233)1, 9 Li Q.... Price D.H. (2005)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. Transcriptional and posttranscriptional regulation of HIV-1 gene expression. (PubMed id 22355797)1 Karn J. and Stoltzfus C.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124790 HGNC: 28591 AceView: FLJ32384 Ensembl:ENSG00000168517 euGenes: HUgn124790
    ECgene: HEXIM2 H-InvDB: HEXIM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HEXIM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HEXIM2 gene:
    Search GeneIP for patents involving HEXIM2

    GeneCards and IP:
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