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Aliases for HEXIM1 Gene

Aliases for HEXIM1 Gene

  • Hexamethylene Bisacetamide Inducible 1 2 3
  • Hexamethylene Bis-Acetamide-Inducible Protein 1 3 4
  • Hexamethylene Bis-Acetamide Inducible 1 3 5
  • Estrogen Down-Regulated Gene 1 Protein 3 4
  • Cardiac Lineage Protein 1 3 4
  • Menage A Quatre Protein 1 3 4
  • CLP1 3 4
  • EDG1 3 4
  • HIS1 3 4
  • MAQ1 3 4
  • Hexamethylene-Bis-Acetamide-Inducible Transcript 1 3
  • Hexamethylene Bisacetamide-Inducible Protein 3
  • Hexamthylene Bis-Acetamide Inducible 1 3
  • Menage A Quatre 1 3
  • Protein HEXIM1 3
  • HMBA-Inducible 3

External Ids for HEXIM1 Gene

Previous GeneCards Identifiers for HEXIM1 Gene

  • GC17P040583
  • GC17P043224
  • GC17P038987

Summaries for HEXIM1 Gene

Entrez Gene Summary for HEXIM1 Gene

  • Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

GeneCards Summary for HEXIM1 Gene

HEXIM1 (Hexamethylene Bisacetamide Inducible 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM2.

UniProtKB/Swiss-Prot for HEXIM1 Gene

  • Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.

Gene Wiki entry for HEXIM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEXIM1 Gene

Genomics for HEXIM1 Gene

Regulatory Elements for HEXIM1 Gene

Enhancers for HEXIM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around HEXIM1 on UCSC Golden Path with GeneCards custom track

Promoters for HEXIM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for HEXIM1 Gene

Chromosome:
17
Start:
45,147,317 bp from pter
End:
45,152,101 bp from pter
Size:
4,785 bases
Orientation:
Plus strand

Genomic View for HEXIM1 Gene

Genes around HEXIM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEXIM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEXIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEXIM1 Gene

Proteins for HEXIM1 Gene

  • Protein details for HEXIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94992-HEXI1_HUMAN
    Recommended name:
    Protein HEXIM1
    Protein Accession:
    O94992
    Secondary Accessions:
    • B2R8Y5

    Protein attributes for HEXIM1 Gene

    Size:
    359 amino acids
    Molecular mass:
    40623 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with HEXIM2; probably dimeric (PubMed:15713661, PubMed:15965233, PubMed:16377779). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:12832472, PubMed:15201869, PubMed:15169877, PubMed:16362050, PubMed:15713661, PubMed:15855166, PubMed:16377779, PubMed:17643375, PubMed:17724342). Interacts with the N-CoR complex through NCOR1 (PubMed:17452463). Interacts with ESR1 and NR3C1 (PubMed:15940264, PubMed:15941832). May interact with NF-kappa-B through RELA (PubMed:12581153). Interacts with CCNT2; mediates formation of a tripartite complex with KPNA2 (PubMed:19883659).
    Miscellaneous:
    • Inhibits Tat activity which is required for HIV-1 transcription.

    Three dimensional structures from OCA and Proteopedia for HEXIM1 Gene

neXtProt entry for HEXIM1 Gene

Post-translational modifications for HEXIM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEXIM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEXIM1 Gene

Domains & Families for HEXIM1 Gene

Protein Domains for HEXIM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HEXIM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94992

UniProtKB/Swiss-Prot:

HEXI1_HUMAN :
  • The coiled-coil domain mediates oligomerization.
  • Belongs to the HEXIM family.
Domain:
  • The coiled-coil domain mediates oligomerization.
Family:
  • Belongs to the HEXIM family.
genes like me logo Genes that share domains with HEXIM1: view

No data available for Gene Families for HEXIM1 Gene

Function for HEXIM1 Gene

Molecular function for HEXIM1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.

Gene Ontology (GO) - Molecular Function for HEXIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 14580347
GO:0005515 protein binding IEA,IPI 12832472
GO:0017069 snRNA binding IDA 14580347
GO:0097322 7SK snRNA binding IDA 12832472
genes like me logo Genes that share ontologies with HEXIM1: view

Phenotypes for HEXIM1 Gene

genes like me logo Genes that share phenotypes with HEXIM1: view

Animal Models for HEXIM1 Gene

MGI Knock Outs for HEXIM1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HEXIM1 Gene

Localization for HEXIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEXIM1 Gene

Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEXIM1 Gene COMPARTMENTS Subcellular localization image for HEXIM1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HEXIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12581153
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 12581153
genes like me logo Genes that share ontologies with HEXIM1: view

Pathways & Interactions for HEXIM1 Gene

genes like me logo Genes that share pathways with HEXIM1: view

Pathways by source for HEXIM1 Gene

1 Cell Signaling Technology pathway for HEXIM1 Gene

Gene Ontology (GO) - Biological Process for HEXIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14580347
GO:0006351 transcription, DNA-templated IEA --
GO:0007507 heart development IEA --
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA 14580347
GO:0045892 negative regulation of transcription, DNA-templated IEA,IDA 14580347
genes like me logo Genes that share ontologies with HEXIM1: view

No data available for SIGNOR curated interactions for HEXIM1 Gene

Drugs & Compounds for HEXIM1 Gene

(2) Additional Compounds for HEXIM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HEXIM1: view

Transcripts for HEXIM1 Gene

mRNA/cDNA for HEXIM1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(165) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HEXIM1 Gene

Hexamethylene bis-acetamide inducible 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEXIM1 Gene

No ASD Table

Relevant External Links for HEXIM1 Gene

GeneLoc Exon Structure for
HEXIM1
ECgene alternative splicing isoforms for
HEXIM1

Expression for HEXIM1 Gene

mRNA expression in normal human tissues for HEXIM1 Gene

Protein differential expression in normal tissues from HIPED for HEXIM1 Gene

This gene is overexpressed in Lung (30.0), Blymphocyte (8.9), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HEXIM1 Gene



Protein tissue co-expression partners for HEXIM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HEXIM1 Gene:

HEXIM1

SOURCE GeneReport for Unigene cluster for HEXIM1 Gene:

Hs.741758

mRNA Expression by UniProt/SwissProt for HEXIM1 Gene:

O94992-HEXI1_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
genes like me logo Genes that share expression patterns with HEXIM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HEXIM1 Gene

Orthologs for HEXIM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEXIM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HEXIM1 34
  • 90.94 (n)
  • 90.31 (a)
HEXIM1 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEXIM1 34
  • 90.99 (n)
  • 90.22 (a)
HEXIM1 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hexim1 34
  • 88.01 (n)
  • 86.52 (a)
Hexim1 16
Hexim1 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HEXIM1 34
  • 100 (n)
  • 100 (a)
HEXIM1 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hexim1 34
  • 86.89 (n)
  • 86.24 (a)
oppossum
(Monodelphis domestica)
Mammalia HEXIM1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves HEXIM1 34
  • 81.36 (n)
  • 80.65 (a)
lizard
(Anolis carolinensis)
Reptilia HEXIM1 35
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2589 34
zebrafish
(Danio rerio)
Actinopterygii wufd44h02 34
hexim1 35
  • 44 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9361 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for HEXIM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEXIM1 Gene

ENSEMBL:
Gene Tree for HEXIM1 (if available)
TreeFam:
Gene Tree for HEXIM1 (if available)

Paralogs for HEXIM1 Gene

Paralogs for HEXIM1 Gene

(1) SIMAP similar genes for HEXIM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HEXIM1: view

Variants for HEXIM1 Gene

Sequence variations from dbSNP and Humsavar for HEXIM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1044977 -- 45,149,847(+) CCGGA(C/T)CTCAA reference, synonymous-codon
rs1044995 -- 45,151,161(+) CTTAG(C/T)GCAAG utr-variant-3-prime
rs1801920 -- 45,150,784(+) GGAGA(A/C)TTTTC utr-variant-3-prime
rs1801921 -- 45,150,822(+) TTTAA(C/G)TATGC utr-variant-3-prime
rs1801922 -- 45,150,359(+) GTGGA(A/C)CTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HEXIM1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv2062 CNV insertion 18451855
nsv527788 CNV loss 19592680
nsv828022 CNV gain 20364138
nsv953903 CNV deletion 24416366

Variation tolerance for HEXIM1 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HEXIM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HEXIM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEXIM1 Gene

Disorders for HEXIM1 Gene

Relevant External Links for HEXIM1

Genetic Association Database (GAD)
HEXIM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEXIM1

No disorders were found for HEXIM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEXIM1 Gene

Publications for HEXIM1 Gene

  1. Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. (PMID: 15713661) Yik J.H.N. … Zhou Q. (J. Biol. Chem. 2005) 3 4 22 65
  2. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. (PMID: 15941832) Shimizu N. … Tanaka H. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 65
  3. Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. (PMID: 15965233) Li Q. … Price D.H. (J. Biol. Chem. 2005) 3 4 22 65
  4. Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. (PMID: 16362050) Barboric M. … Peterlin B.M. (EMBO J. 2005) 3 4 22 65
  5. A human immunodeficiency virus type 1 Tat-like arginine-rich RNA- binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. (PMID: 15169877) Yik J.H.N. … Zhou Q. (Mol. Cell. Biol. 2004) 3 4 22 65

Products for HEXIM1 Gene

Sources for HEXIM1 Gene

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