Aliases for HEXIM1 Gene
External Ids for HEXIM1 Gene
Previous GeneCards Identifiers for HEXIM1 Gene
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]
GeneCards Summary for HEXIM1 Gene
HEXIM1 (Hexamethylene Bisacetamide Inducible 1) is a Protein Coding gene. Diseases associated with HEXIM1 include Hiv-1. Among its related pathways are Chromatin Regulation / Acetylation and Initiation of transcription and translation elongation at the HIV-1 LTR. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM2.
UniProtKB/Swiss-Prot for HEXIM1 Gene
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.