Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HEXDC Gene

protein-coding   GIFtS: 50
GCID: GC17P080379

hexosaminidase (glycosyl hydrolase family 20, catalytic...

 Explore 6 diseases affiliated with
HEXDC via our new
 Human Malady Compendium 
Biological research products
for HEXDC
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Hexosaminidase (Glycosyl Hydrolase Family 20, Catalytic Domain)
Containing1 2
     Beta-N-Acetylhexosaminidase1
Beta-Hexosaminidase D2 3     Hexosaminidase D2
Hexosaminidase Domain-Containing Protein2 3     Beta-N-Acetylhexosaminidase1
N-Acetyl-Beta-Galactosaminidase1     EC 3.2.1.523
FLJ238251     

External Ids:    HGNC: 263071   Entrez Gene: 2840042   Ensembl: ENSG000001696607   UniProtKB: Q8WVB33   

Export aliases for HEXDC gene to outside databases

Previous GC identifers: GC17P077971 GC17P080377 GC17P075774


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HEXDC_HUMAN, Q8WVB3
Function: Has hexosaminidase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010663.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HEXDC gene promoter:
         p53   STAT5A   Arnt   YY1   Max   AREB6   FOXJ2 (long isoform)   FOXO4   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHEXDC promoter sequence
   Search SABiosciences Chromatin IP Primers for HEXDC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEXDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

HEXDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEXDC gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080379:  view genomic region     (about GC identifiers)

Start:
80,376,194 bp from pter      End:
80,400,521 bp from pter
Size:
24,328 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HEXDC_HUMAN, Q8WVB3 (See protein sequence)
Recommended Name: Hexosaminidase D  
Size: 486 amino acids; 53790 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Cytoplasm. Nucleus (By similarity)
Sequence caution: Sequence=AAH18205.2; Type=Erroneous initiation; Sequence=AAH35561.1; Type=Erroneous initiation;
Sequence=BAB85072.1; Type=Erroneous initiation;
Secondary accessions: B7UUP6 Q8IYN4 Q8TE81
Alternative splicing: 2 isoforms:  Q8WVB3-1   Q8WVB3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HEXDC: NX_Q8WVB3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WVB3

  • HEXDC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_775891.2  
    ENSEMBL proteins: 
     ENSP00000337854   ENSP00000462856   ENSP00000462923   ENSP00000463129   ENSP00000464497  
     ENSP00000332634   ENSP00000463625   ENSP00000462303   ENSP00000464912   ENSP00000462000  
     ENSP00000463241   ENSP00000465465  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HEXDC
    OriGene Custom Protein Services for HEXDC 
    GenScript Custom Purified and Recombinant Proteins Services for HEXDC
    Novus Biologicals HEXDC Protein
    Novus Biologicals HEXDC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HEXDC

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    HEXDC for ontologies           About GeneDecksing



    HEXDC Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HEXDC 
    GenScript Custom Superior Antibodies Services for HEXDC
    Novus Biologicals HEXDC Antibodies
    Search for Antibodies for HEXDC at Abcam  
    Uscn Antibodies for HEXDC
    Search ThermoFisher Antibodies for HEXDC

    Assay Products for HEXDC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HEXDC
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HEXDC


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HEXDC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015883 Glyco_hydro_20_cat-core
     IPR017853 Glycoside_hydrolase_SF
     IPR013781 Glyco_hydro_catalytic_dom

    Graphical View of Domain Structure for InterPro Entry Q8WVB3

    ProtoNet protein and cluster: Q8WVB3

    UniProtKB/Swiss-Prot: HEXDC_HUMAN, Q8WVB3
    Similarity: Belongs to the glycosyl hydrolase 20 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HEXDC_HUMAN, Q8WVB3
    Function: Has hexosaminidase activity
    Catalytic activity: Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
    Enzyme regulation: Inhibited by O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate (PUGNAc) (By
    similarity)

    Enzyme Number (IUBMB): EC 3.2.1.521

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: HEXDC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEXDC
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HEXDC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEXDC (see all 7)
    OriGene shRNA RFP: HEXDC
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEXDC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HEXDC

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEXDC (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEXDC (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HEXDC (NM_173620)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEXDC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEXDC 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HEXDC
    Search LifeMap BioReagents cell lines for HEXDC

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEXDC

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004563beta-N-acetylhexosaminidase activity IEA--
    GO:0043169cation binding IEA--


    HEXDC for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Other glycan degradation
    Other glycan degradation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for HEXDC):
        Other glycan degradation


    HEXDC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HEXDC

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/18 Interacting proteins for HEXDC (Q8WVB32, 3 ENSP000003378544) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RILPL2Q969X02, 3, ENSP000002805714MINT-65047 I2D: score=5 STRING: ENSP00000280571
    ADPRHL2Q9NX462, 3MINT-65045 I2D: score=5 
    GLRX3O760032, 3MINT-65043 I2D: score=5 
    GDPD2Q9HCC82, 3, ENSP000003635034MINT-65049 I2D: score=5 STRING: ENSP00000363503
    C7orf25Q9BPX73, ENSP000004162904I2D: score=4 STRING: ENSP00000416290
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--


    HEXDC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HEXDC
    Search CenterWatch for drugs/clinical trials and news about HEXDC 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HEXDC gene: 
    NM_173620.2  

    Unigene Cluster for HEXDC:

    Hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
    Hs.744207  [show with all ESTs]
    Unigene Representative Sequence: NM_173620
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337014(uc002kev.4 uc002kew.3) ENST00000583978 ENST00000580235
    ENST00000582315 ENST00000577944 ENST00000581482 ENST00000327949 ENST00000578632
    ENST00000578775 ENST00000582429(uc010wvm.2) ENST00000578130 ENST00000585077(uc010wvn.1)
    ENST00000578616 ENST00000583354 ENST00000582131

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: HEXDC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HEXDC
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HEXDC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEXDC (see all 7)
    OriGene shRNA RFP: HEXDC
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEXDC
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEXDC (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEXDC (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HEXDC (NM_173620)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEXDC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEXDC 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEXDC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HEXDC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEXDC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEXDC

    Additional cDNA sequence: 

    AK074405.1 AK295197.1 AK297272.1 AK316085.1 BC018205.1 BC035561.1 FM204887.1 

    18 DOTS entries:

    DT.100813438  DT.100027909  DT.40190162  DT.100022809  DT.70101230  DT.70101660  DT.87015923  DT.97798244 
    DT.99931951  DT.75163147  DT.91750956  DT.92420817  DT.95120003  DT.97766449  DT.97789035  DT.120922213 
    DT.120922308  DT.97762440 

    24/67 AceView cDNA sequences (see all 67):

    BM917626 BU685475 AW276184 BU557293 AA988387 BU740920 AI479435 AI700511 
    BM980844 BC018205 AW025445 AK074405 CR607308 AW275477 BF528474 BM547527 
    BU552660 CA392716 BF512173 BI915563 BI825525 BU849420 CA434062 BG035677 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HEXDC (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:                          -                 -                                                           -     -     -                                       
    SP2:                                                                                                                                                            
    SP3:                          -     -     -                                                                                                                     
    SP4:                          -     -     -                                                                                                                     
    SP5:                          -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for HEXDC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HEXDC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGACACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HEXDC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HEXDC

    SOURCE GeneReport for Unigene cluster: Hs.744207
        SABiosciences Custom PCR Arrays for HEXDC
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEXDC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HEXDC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEXDC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEXDC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEXDC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HEXDC gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hexdc1 , 5 hexosaminidase (glycosyl hydrolase family 20, catalytic more1, 5 78.02(n)1
    78.67(a)1
      11 (85.08 cM)5
    2380231  NM_001001333.21  NP_001001333.21 
     1212044355 
    chicken
    (Gallus gallus)
    Aves HEXDC1 hexosaminidase (glycosyl hydrolase family 20, catalytic more 65.79(n)
    64.52(a)
      417343  XM_003642331.1  XP_003642379.1 
    lizard
    (Anolis carolinensis)
    Reptilia HEXDC6
    --
    35(a)
    1 ↔ 1
    2(109539912-109563229)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135052 Xenopus laevis transcribed sequence with weak similarity more 76.24(n)    BX843520.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj33c042 Transcribed sequence with weak similarity to protein more 80.06(n)    BM103166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79851 CG7985 53.5(n)
    50(a)
      42178  NM_142432.2  NP_650689.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hex-56
    hex-46
    (see all 4)
    Hexosaminidase; Protein HEX-4
    (see all 4)
    26(a)
    25(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    X(14901824-14905192)
    I(1924302-1932262)


    ENSEMBL Gene Tree for HEXDC (if available)
    TreeFam Gene Tree for HEXDC (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/437 NCBI SNPs in HEXDC are shown (see all 437    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115847401,2
    C,--75779915(+) GAGAGC/AGCGAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs740016871,2
    C,--75780414(+) ACAGTC/TTCCAC 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs740016881,2
    C,--75780873(+) CCCTAC/TAGGGA 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs774536811,2
    C,--75781061(+) AGGCTG/AGAGAA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs760344821,2
    C,--75781738(+) GATAAA/GTGCAC 1 -- nc-transcript-variant2Minor allele frequency- G:0.04WA 120
    rs748607431,2
    C,--75781744(+) TGCACA/GATGGA 1 -- nc-transcript-variant2Minor allele frequency- G:0.04WA 120
    rs745952811,2
    C,--75782143(+) AGGAGG/CATGGC 1 -- nc-transcript-variant2Minor allele frequency- C:0.05WA 120
    rs597707391,2
    C,--75782978(+) TGGGCG/ATGGCC 1 -- nc-transcript-variant1Minor allele frequency- A:0.50WA 2
    rs759958881,2
    F,--75783544(+) GACTTC/TGGTTC 1 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1424149771,2
    --80378522(+) TACTGC/TAACCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HEXDC (80376194 - 80400521 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HEXDC
         2 CNVs: 5043 73078

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEXDC
    DNA2.0 Custom Variant and Variant Library Synthesis for HEXDC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HEXDC for disorders           About GeneDecksing

    6 diseases for HEXDC:    About MalaCards
    tay-sachs disease    mesenteric vascular occlusion    sandhoff disease    gangliosidosis
    nephropathy    hypertension

    1 disease from the University of Copenhagen DISEASES database for HEXDC:
    Pthirus pubis infestation

    Export disorders for HEXDC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HEXDC gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HEXDC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian cells contain a second nucleocytoplasmic hexosaminidase. (PubMed id 19040401)1, 2, 9 Gutternigg M.... Wilson I.B. (2009)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Are recently reported biomarkers helpful for early and accurate diagnosis of acute kidney injury? (PubMed id 22515481)1 Barrera-Chimal J. and Bobadilla N.A. (2012)
    4. Urinary proteins, N-acetyl-I^-D-glucosaminidase activi ty and estimated glomerular filtration rate in hypertensive patients with normo albuminuria and microalbuminuria. (PubMed id 21265931)1 Lisowska-Myjak B....Gaciong Z. (2011)
    5. Assessment of urinary N-acetyl-I^-glucosaminidase as a n early marker of contrast-induced nephropathy. (PubMed id 21672370)1 Ren L....Ding X.Q. (2011)
    6. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284004 HGNC: 26307 AceView: FLJ23825 Ensembl:ENSG00000169660 euGenes: HUgn284004
    ECgene: HEXDC Kegg: 284004 H-InvDB: HEXDC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HEXDC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HEXDC gene:
    Search GeneIP for patents involving HEXDC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HEXDC  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEXDC   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEXDC  
     OriGene Protein Over-expression Lysate for HEXDC   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for HEXDC  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEXDC   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEXDC  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HEXDC   OriGene Custom Protein Services for HEXDC  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HEXDC
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEXDC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEXDC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEXDC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEXDC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEXDC
     GenScript Custom Purified and Recombinant Proteins Services for HEXDC GenScript cDNA clones with any tag delivered in your preferred vector for HEXDC
     GenScript Custom Assay Services for HEXDC GenScript Custom Superior Antibodies Services for HEXDC
     GenScript Custom overexpressing Cell Line Services for HEXDC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HEXDC promoter
     Search Chromatin IP Primers for HEXDC
     RT2 qPCR Primer Assay in human, mouse, rat HEXDC
     Search GNC Networks for HEXDC
     SABiosciences Custom PCR Arrays for HEXDC
     Search Tocris compounds for HEXDC
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HEXDC antibodies
     HEXDC proteins
     HEXDC lysates
     Search for Antibodies for HEXDC at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HEXDC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HEXDC Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HEXDC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEXDC
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HEXDC
     SwitchGear Promoter luciferase reporter plasmids for HEXDC
     Search ThermoFisher Antibodies for HEXDC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEXDC
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HEXDC gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4