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HES7 Gene

protein-coding   GIFtS: 52
GCID: GC17M008060

Hes Family BHLH Transcription Factor 7

(Previous name: hairy and enhancer of split 7 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hes Family BHLH Transcription Factor 71 2     hHes72 3
BHLH Factor Hes71 2 3     SCDO42 5
Class B Basic Helix-Loop-Helix Protein 372 3     Hairy And Enhancer Of Split 7 (Drosophila)1
Hairy And Enhancer Of Split 72 3     Transcription Factor HES-72
bHLHb372 3     BHLHB373

External Ids:    HGNC: 159771   Entrez Gene: 846672   Ensembl: ENSG000001791117   OMIM: 6080595   UniProtKB: Q9BYE03   

Export aliases for HES7 gene to outside databases

Previous GC identifers: GC17P008428 GC17M009113 GC17M007966 GC17M008226 GC17M008227 GC17M007965 GC17M008030 GC17M007919 GC17M008046 GC17M008051 GC17M008056


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HES7 Gene:
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse
ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and
is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in
spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this
gene.(provided by RefSeq, Sep 2009)

GeneCards Summary for HES7 Gene:
HES7 (hes family bHLH transcription factor 7) is a protein-coding gene. Diseases associated with HES7 include spondylocostal dysostosis 4, autosomal recessive, and hes7-related spondylocostal dysostosis, autosomal recessive. GO annotations related to this gene include protein dimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot: HES7_HUMAN, Q9BYE0
Function: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May
with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a
segmentation clock, which is essential for coordinated somite segmentation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HES7 gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   Tal-1beta   LCR-F1   GATA-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHES7 promoter sequence
   Search Chromatin IP Primers for HES7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HES7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

HES7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008060:  view genomic region     (about GC identifiers)

Start:
8,023,908 bp from pter      End:
8,027,410 bp from pter
Size:
3,503 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HES7_HUMAN, Q9BYE0 (See protein sequence)
Recommended Name: Transcription factor HES-7  
Size: 225 amino acids; 24899 Da
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE
family (By similarity)
Secondary accessions: F8VPC9
Alternative splicing: 2 isoforms:  Q9BYE0-1   Q9BYE0-2   

Explore the universe of human proteins at neXtProt for HES7: NX_Q9BYE0

Explore proteomics data for HES7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HES7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159439.1  NP_115969.2  

    ENSEMBL proteins: 
     ENSP00000446205   ENSP00000314774   ENSP00000462491  

    HES7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HES7
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    Novus Biologicals HES7 Protein
    Novus Biologicals HES7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HES7
    Cloud-Clone Corp. Proteins for HES7

    HES7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for HES7
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    LSBio Antibodies in human, mouse, rat for HES7

    HES7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HES7
    Cloud-Clone Corp. CLIAs for HES7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR003650 Orange
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9BYE0

    ProtoNet protein and cluster: Q9BYE0

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB003650 Orange


    UniProtKB/Swiss-Prot: HES7_HUMAN, Q9BYE0
    Domain: Has a particular type of basic domain which includes a helix-interrupting proline
    Domain: The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with
    Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related
    proteins (By similarity)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 Orange domain


    HES7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HES7_HUMAN, Q9BYE0
    Function: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May
    with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a
    segmentation clock, which is essential for coordinated somite segmentation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS11260262
    GO:0008134transcription factor binding NAS17611704
    GO:0046983protein dimerization activity IEA--
         
    HES7 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hes7):
     embryogenesis  growth/size/body  limbs/digits/tail  mortality/aging  skeleton 

    HES7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HES7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HES7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HES7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HES7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HES7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HES7 (see all 22):
    hsa-miR-4265 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-331-3p hsa-miR-346 hsa-miR-23b* hsa-miR-4309 hsa-miR-100
    SwitchGear 3'UTR luciferase reporter plasmidHES7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HES7
    Predesigned siRNA for gene silencing in human, mouse, rat HES7

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HES7 (NM_032580)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HES7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HES7_HUMAN, Q9BYE0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11260262

    HES7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HES7: 
              Notch Signaling Targets in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HES7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HES7 (ENSP000003147744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001501skeletal system development IEA--
    GO:0001756somitogenesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    HES7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HES7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HES7 gene (2 alternative transcripts): 
    NM_001165967.1  NM_032580.3  

    Unigene Cluster for HES7:

    Hairy and enhancer of split 7 (Drosophila)
    Hs.434828  [show with all ESTs]
    Unigene Representative Sequence: BM808440
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541682(uc002gkb.2 uc002gkc.3) ENST00000317814 ENST00000577735

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HES7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HES7 (see all 22):
    hsa-miR-4265 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-331-3p hsa-miR-346 hsa-miR-23b* hsa-miR-4309 hsa-miR-100
    SwitchGear 3'UTR luciferase reporter plasmidHES7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HES7
    Predesigned siRNA for gene silencing in human, mouse, rat HES7
    Clone
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    OriGene clones in human, mouse for HES7 (see all 9)
    OriGene ORF clones in mouse, rat for HES7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HES7 (NM_032580)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HES7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HES7
      QuantiTect SYBR Green Assays in human, mouse, rat HES7
      QuantiFast Probe-based Assays in human, mouse, rat HES7

    Additional mRNA sequence: 

    AB049064.1 BC039887.1 

    1 DOTS entry:

    DT.100020691 

    13 AceView cDNA sequences:

    BF058233 NR_000038 BU620502 BI335370 BU633860 AB049064 CA432402 BU629441 
    CA432404 NM_032580 BC039887 BI259590 BQ930883 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HES7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                    -               
    SP2:                                    


    ECgene alternative splicing isoforms for HES7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HES7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATAAAGTG
    HES7 Expression
    About this image


    HES7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
     
     Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
    HES7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HES7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434828
        Pathway & Disease-focused RT2 Profiler PCR Array including HES7: 
              Notch Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HES7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HES7 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hes71 , 5 hairy and enhancer of split 7 (Drosophila)1, 5 92(n)1
    92(a)1
      11 (42.38 cM)5
    846531  NM_033041.41  NP_149030.21 
     691204045 
    lizard
    (Anolis carolinensis)
    Reptilia HES76
    hes family bHLH transcription factor 7
    31(a)
    1 ↔ 1
    GL343400.1(526157-535117)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983562 bHLH-WRPW transcription factor ESR-5 76.19(n)    AF137072.1 
    zebrafish
    (Danio rerio)
    Actinopterygii her56
    hairy-related 5
    32(a)
    1 ↔ 1
    14(31412619-31414295) ENSDARG00000008796


    ENSEMBL Gene Tree for HES7 (if available)
    TreeFam Gene Tree for HES7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HES7 (see all 106)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0649224
    Spondylocostal dysostosis 4, autosomal recessive (SCDO4)4--see VAR_0649222 I V mis40--------
    VAR_0649234
    Spondylocostal dysostosis 4, autosomal recessive (SCDO4)4--see VAR_0649232 D Y mis40--------
    VAR_0649214
    Spondylocostal dysostosis 4, autosomal recessive (SCDO4)4--see VAR_0649212 R W mis40--------
    rs1414183621,2
    --7919137(+) CCGTTC/TGTCGG 2 -- ut310--------
    rs1870621641,2
    --7919138(+) CGTTCA/GTCGGG 2 -- ut310--------
    rs14428501,2
    C,F,A,H--7919139(+) GTTCGC/TCGGGT 2 -- ut3119Minor allele frequency- T:0.07NS EA NA WA CSA 1543
    rs1906399171,2
    --7919143(+) GTCGGA/GTGGCT 2 -- ut310--------
    rs1508117541,2
    C--7919187(+) GTGACC/GAATAG 2 -- ut310--------
    rs1828855081,2
    --7919189(+) GACGAA/CTAGAG 2 -- ut310--------
    rs1874888201,2
    --7919199(+) GCAATG/TCAAAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HES7 (8023908 - 8027410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HES7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv457661CNV Loss19166990
    nsv907657CNV Loss21882294
    nsv833352CNV Loss17160897

    Human Gene Mutation Database (HGMD): HES7
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HES7
    DNA2.0 Custom Variant and Variant Library Synthesis for HES7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608059   
    OMIM disorders: 613686  
    UniProtKB/Swiss-Prot: HES7_HUMAN, Q9BYE0
  • Spondylocostal dysostosis 4 (SCDO4) [MIM:613686]: A rare condition of variable severity characterized by
    vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib
    fusion, reduced rib number, and other rib malformations. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 13 diseases for HES7:    
    About MalaCards
    spondylocostal dysostosis 4, autosomal recessive    hes7-related spondylocostal dysostosis, autosomal recessive    spondylocostal dysostosis 4    dysostosis
    spondylocostal dysostosis 1    spondylocostal dysostosis, autosomal recessive    spondylocostal dysostosis    dwarfism
    childhood leukemia    meningioma    multiple myeloma    myeloma
    leukemia

    1 disease from the University of Copenhagen DISEASES database for HES7:
    Spondylocostal dysostosis

    HES7 for disorders           About GeneDecksing

    GeneTests: HES7
    GeneReviews: HES7
    Genetic Association Database (GAD): HES7
    Human Genome Epidemiology (HuGE) Navigator: HES7 (7 documents)

    Export disorders for HES7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HES7 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with HES7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PubMed id 11260262)1, 2, 3 Bessho Y.... Kageyama R. (Genes Cells 2001)
    2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    3. Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis. (PubMed id 20087400)1, 2 Sparrow D.B....Dunwoodie S.L. (Eur. J. Hum. Genet. 2010)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis. (PubMed id 18775957)1, 2 Sparrow D.B.... Dunwoodie S.L. (Hum. Mol. Genet. 2008)
    7. Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus. (PubMed id 23897666)1 Sparrow D.B....Dunwoodie S.L. (Am. J. Med. Genet. A 2013)
    8. Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis. (PubMed id 22744456)1 Qiu X.S....Qiu Y. (Stud Health Technol Inform 2012)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84667 HGNC: 15977 AceView: HES7 Ensembl:ENSG00000179111 euGenes: HUgn84667
    ECgene: HES7 H-InvDB: HES7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HES7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for HES7 gene:
    Search GeneIP for patents involving HES7

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