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HES6 Gene

protein-coding   GIFtS: 59
GCID: GC02M239205

Hes Family BHLH Transcription Factor 6

(Previous name: hairy and enhancer of split 6 (Drosophila))
  See HES6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hes Family BHLH Transcription Factor 61 2     Hairy And Enhancer Of Split 6 (Drosophila)1
Class B Basic Helix-Loop-Helix Protein 412 3     HES-62
Hairy And Enhancer Of Split 62 3     bHLHc232
C-HAIRY12 3     Transcription Cofactor HES-62
bHLHb412 3     BHLHB413

External Ids:    HGNC: 182541   Entrez Gene: 555022   Ensembl: ENSG000001444857   OMIM: 6103315   UniProtKB: Q96HZ43   

Export aliases for HES6 gene to outside databases

Previous GC identifers: GC02M237195 GC02M237828 GC02M239163 GC02M239433 GC02M238928 GC02M238812 GC02M230937 GC02M239166 GC02M239172 GC02M239187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HES6 Gene:
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to
the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous
cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription
factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding
different isoforms have been described.(provided by RefSeq, Dec 2008)

GeneCards Summary for HES6 Gene:
HES6 (hes family bHLH transcription factor 6) is a protein-coding gene. Diseases associated with HES6 include mood disorder, and alveolar rhabdomyosarcoma. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4
Function: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression
and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by
ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell
differentiation (By similarity)

Gene Wiki entry for HES6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HES6 gene promoter:
         Nkx3-1   Elk-1   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHES6 promoter sequence
   Search Chromatin IP Primers for HES6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HES6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

HES6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M239205:  view genomic region     (about GC identifiers)

Start:
239,146,908 bp from pter      End:
239,149,303 bp from pter
Size:
2,396 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4 (See protein sequence)
Recommended Name: Transcription cofactor HES-6  
Size: 224 amino acids; 24129 Da
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE
family. Interacts with HES1 (By similarity)
Secondary accessions: A8KAP6 Q53SN9 Q8N2J2 Q96T93 Q9P2S3
Alternative splicing: 3 isoforms:  Q96HZ4-1   Q96HZ4-2   Q96HZ4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HES6: NX_Q96HZ4

Explore proteomics data for HES6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HES6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001136325.1  NP_001269363.1  NP_061115.2  

    ENSEMBL proteins: 
     ENSP00000272937   ENSP00000387215   ENSP00000387155   ENSP00000387343   ENSP00000401797  
     ENSP00000387008   ENSP00000387107   ENSP00000392596   ENSP00000390870  

    HES6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR003650 Orange
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q96HZ4

    ProtoNet protein and cluster: Q96HZ4

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB003650 Orange


    UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4
    Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with
    Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related
    proteins (By similarity)
    Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box
    (CACNAG), rather than the canonical E-box (CANNTG)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 Orange domain


    Find genes that share domains with HES6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HES6_HUMAN, Q96HZ4
    Function: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression
    and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by
    ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell
    differentiation (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003712transcription cofactor activity ISS10851137
    GO:0008134transcription factor binding NAS17611704
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with HES6           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HES6:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HES6
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    miRNA
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    miRTarBase miRNAs that target HES6:
    hsa-mir-215-5p (MIRT024636), hsa-mir-192-5p (MIRT026430), hsa-mir-320a (MIRT044433)

    Block miRNA regulation of human, mouse, rat HES6 using miScript Target Protectors
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    Browse Sino Biological Human cDNA Clones
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    eBioscience FlowRNA Probe Sets ( VA1-12964) for HES6 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HES6_HUMAN, Q96HZ4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex ISS10851137

    Find genes that share ontologies with HES6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HES6 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33
    2Notch-mediated HES/HEY network
    Notch-mediated HES/HEY network


    2 BioSystems Pathways for HES6
        Delta-Notch Signaling Pathway
    Notch-mediated HES/HEY network


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HES6
    Interactions:

        GeneGlobe Interaction Network for HES6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for HES6 (Q96HZ42, 3 ENSP000002729374) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    CSNK2A1P684003, ENSP000002172444I2D: score=1 STRING: ENSP00000217244
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    HES1Q144693, ENSP000002324244I2D: score=2 STRING: ENSP00000232424
    TLE1Q047243, ENSP000003656824I2D: score=3 STRING: ENSP00000365682
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS10851137
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with HES6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HES6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HES6 gene (3 alternative transcripts): 
    NM_001142853.2  NM_001282434.1  NM_018645.5  

    Unigene Cluster for HES6:

    Hairy and enhancer of split 6 (Drosophila)
    Hs.42949  [show with all ESTs]
    Unigene Representative Sequence: BI552301
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272937(uc002vxz.3 uc002vya.3) ENST00000409160(uc002vyb.2)
    ENST00000409002 ENST00000409182 ENST00000417803 ENST00000409574 ENST00000409356
    ENST00000436051 ENST00000450098
    miRNA
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    Block miRNA regulation of human, mouse, rat HES6 using miScript Target Protectors
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    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for HES6
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HES6
      QuantiTect SYBR Green Assays in human, mouse, rat HES6
      QuantiFast Probe-based Assays in human, mouse, rat HES6
    Flow Cytometry
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    Additional mRNA sequence: 

    AB035179.1 AF260237.1 AK293111.1 BC007939.2 

    9 DOTS entries:

    DT.92430558  DT.85104201  DT.100783206  DT.120999447  DT.95306279  DT.85104204  DT.95306280  DT.87046042 
    DT.95306273 

    Selected AceView cDNA sequences (see all 204):

    AA045442 AA167753 BE795322 AW249678 BM824529 AI082815 BQ682515 AA059461 
    BM825382 BM015683 AI241958 BU944044 AI424469 BE855679 BM042089 BM827249 
    AF260237 BE796220 BM480143 CR610232 BM789450 BE855476 AI436215 BE222726 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HES6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
    SP1:                                    
    SP2:                                    
    SP3:                                    


    ECgene alternative splicing isoforms for HES6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HES6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCTGCGTG
    HES6 Expression
    About this image


    HES6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
             Midbrain dopaminergic-like neurons
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
    HES6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HES6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42949
        Custom PCR Arrays for HES6
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HES6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hes61 , 5 hairy and enhancer of split 6 (Drosophila)5
    hairy and enhancer of split 61
    83.93(n)1
    85.71(a)1
      1 (46.12 cM)5
    559271  NM_019479.31  NP_062352.11 
     914114835 
    chicken
    (Gallus gallus)
    Aves HES66
    hes family bHLH transcription factor 6
    26(a)
    1 ↔ 1
    9(4942248-4948675)
    lizard
    (Anolis carolinensis)
    Reptilia HES66
    hes family bHLH transcription factor 6
    58(a)
    1 ↔ 1
    3(28067051-28075685)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.2092 Xenopus laevis cDNA clone 10C6 77.63(n)    AJ009284.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hes62 hairy and enhancer of split 6 (Drosophila) 73.57(n)   373116  BC062387.1 


    ENSEMBL Gene Tree for HES6 (if available)
    TreeFam Gene Tree for HES6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HES6 gene
    HES42  HES52  HES22  HES12  
    3 SIMAP similar genes for HES6 using alignment to 7 protein entries:     HES6_HUMAN (see all proteins):
    HES2    HES4    HES1

    Find genes that share paralogs with HES6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HES6 (see all 61)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs795881221,2
    F--239146475(+) CACAAG/ATAGAC 2 -- ds50011Minor allele frequency- A:0.10WA 118
    rs1921990581,2
    --239146515(+) AAACAG/TGTCTT 2 -- ds50010--------
    rs1396070801,2
    --239146516(+) AACAGA/GTCTTT 2 -- ds50010--------
    rs729760981,2
    C--239146661(+) ACAAAC/ATCCTT 2 -- ds50013Minor allele frequency- A:0.22NA EA 242
    rs729760991,2
    C,F--239146778(+) CACCAT/CCACAC 2 -- ds50013Minor allele frequency- C:0.23NA EA 242
    rs134259491,2
    C--239146869(+) ATTTAC/AATATC 2 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1155999111,2
    F--239146948(+) TAAAAT/CTGTCA 2 -- ut311Minor allele frequency- C:0.01WA 118
    rs88351,2
    C,F--239147036(+) CAGCTC/GAGTGC 2 -- ut316Minor allele frequency- G:0.39MN NA CSA EA 615
    rs72401,2
    C,F,A,H--239147129(+) CCATTT/CCTGCC 2 -- ut3118Minor allele frequency- C:0.33MN NS EA WA NA CSA 1153
    rs15503771,2
    C,F--239147152(-) GTGCGG/CGCTCT 2 -- ut315Minor allele frequency- C:0.17MN EA NA WA 358

    HapMap Linkage Disequilibrium report for HES6 (239146908 - 239149303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HES6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21505CNV Loss19812545
    nsv876067CNV Loss21882294

    Human Gene Mutation Database (HGMD): HES6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HES6
    DNA2.0 Custom Variant and Variant Library Synthesis for HES6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610331    OMIM disorders: --

    3 diseases for HES6:    
    About MalaCards
    mood disorder    alveolar rhabdomyosarcoma    autism spectrum disorder


    Find genes that share disorders with HES6           About GenesLikeMe

    3 Novoseek inferred disease relationships for HES6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 31.5 2 17611704 (1)
    brain tumors 30.8 1 17611704 (1)
    tumors 0 1 17611704 (1)

    Genetic Association Database (GAD): HES6
    Human Genome Epidemiology (HuGE) Navigator: HES6 (2 documents)

    Export disorders for HES6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HES6 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with HES6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. (PubMed id 10851137)1, 2, 3, 9 Bae S.-K.... Kageyama R. (Development 2000)
    2. Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response. (PubMed id 19481584)1, 4 Glubb D.M....Kennedy M.A. (Neurosci. Lett. 2009)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors. (PubMed id 11044617)1, 2 Vasiliauskas D. and Stern C.D. (Mech. Dev. 2000)
    8. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. (PubMed id 12972610)1, 9 Gratton M.O....Stifani S. (Mol. Cell. Biol. 2003)
    9. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PubMed id 17611704)1, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2007)
    10. HES6 enhances the motility of alveolar rhabdomyosarcoma cells. (PubMed id 22982728)1 Wickramasinghe C.M....Jones P.H. (Exp. Cell Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55502 HGNC: 18254 AceView: HES6 Ensembl:ENSG00000144485 euGenes: HUgn55502
    ECgene: HES6 H-InvDB: HES6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HES6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HES6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HES6 gene:
    Search GeneIP for patents involving HES6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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