Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HES6 Gene

protein-coding GIFtS: 57
GCID: GC02M239172

hairy and enhancer of split 6 (Drosophila)

Explore 9 diseases affiliated with
HES6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hairy And Enhancer Of Split 6 (Drosophila)¹ ²		BHLHc23¹
BHLHb41¹		Transcription Cofactor HES-6²
Class B Basic Helix-Loop-Helix Protein 41² ³		BHLHB41³
C-HAIRY1² ³		Hairy And Enhancer Of Split 6³
HES-6²

External Ids:	HGNC: 18254¹	Entrez Gene: 55502²	Ensembl: ENSG00000144485⁷	OMIM: 610331⁵	UniProtKB: Q96HZ4³

Export aliases for HES6 gene to outside databases

Previous GC identifers: GC02M237195 GC02M237828 GC02M239163 GC02M239433 GC02M238928 GC02M238812 GC02M230937 GC02M239166

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HES6:

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the

Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types.

The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a

tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been

described.(provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4

Function: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and

binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1

and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By

similarity)

Gene Wiki entry for HES6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005120.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HES6 gene promoter:
Nkx3-1 Elk-1 MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HES6 promoter sequence

Search SABiosciences Chromatin IP Primers for HES6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3

HES6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES6 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M239172: view genomic region (about GC identifiers)

Start:	239,146,908 bp from pter	End:	239,149,303 bp from pter
Size:	2,396 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4 (See protein sequence)

Recommended Name: Transcription cofactor HES-6

Size: 224 amino acids; 24129 Da

Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

Interacts with HES1 (By similarity)

Subcellular location: Nucleus (Probable)

Secondary accessions: A8KAP6 Q53SN9 Q8N2J2 Q96T93 Q9P2S3

Alternative splicing: 3 isoforms: Q96HZ4-1 Q96HZ4-2 Q96HZ4-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HES6: NX_Q96HZ4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96HZ4

HES6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001136325.1 NP_061115.2

ENSEMBL proteins:

ENSP00000272937 ENSP00000387215 ENSP00000387155 ENSP00000387343 ENSP00000401797

ENSP00000387008 ENSP00000387107 ENSP00000392596 ENSP00000390870

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: HES6 OriGene Protein Over-expression Lysate (see all 2): HES6 OriGene Custom Protein Services for HES6
	GenScript Custom Purified and Recombinant Proteins Services for HES6
	Novus Biologicals HES6 Protein Novus Biologicals HES6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HES6

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005667	transcription factor complex	ISS	10851137

HES6 for ontologies About GeneDecksing

HES6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 4): HES6 OriGene Custom Antibody Services for HES6
	GenScript Custom Superior Antibodies Services for HES6
	Novus Biologicals HES6 Antibodies
	Search for Antibodies for HES6 at Abcam
	Uscn Antibodies for HES6
	ThermoFisher Antibodies for HES6

Assay Products for HES6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HES6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HES6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HES6 for domains About GeneDecksing

2 InterPro domains/families:

IPR003650 Orange

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry Q96HZ4

ProtoNet protein and cluster: Q96HZ4

2 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB003650 Orange

UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4

Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE

family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By

similarity)

Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box

(CACNAG), rather than the canonical E-box (CANNTG)

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 Orange domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4

Function: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and

binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1

and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By

similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HES6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HES6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HES6
		SwitchGear 3'UTR luciferase reporter plasmid: HES6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HES6 (see all 7) OriGene shRNA RFP: HES6 OriGene siRNA: HES6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HES6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HES6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HES6 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HES6 (NM_001142853)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HES6
		Search LifeMap BioReagents cell lines for HES6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES6

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003712	transcription cofactor activity	ISS	10851137
GO:0008134	transcription factor binding	NAS	17611704
GO:0046983	protein dimerization activity	IEA	--

HES6 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for HES6:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Notch-mediated HES/HEY network

Notch-mediated HES/HEY network

1.00

Notch Signaling Pathway

Delta-Notch Signaling Pathway

0.27

2 BioSystems Pathways for HES6

	Delta-Notch Signaling Pathway
	Notch-mediated HES/HEY network

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HES6

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/18 Interacting proteins for HES6 (Q96HZ4^{2, 3} ENSP00000272937⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HES1	Q14469³, ENSP00000232424⁴	I2D: score=2 STRING: ENSP00000232424
EP300	Q09472³, ENSP00000263253⁴	I2D: score=1 STRING: ENSP00000263253
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=1 STRING: ENSP00000262367
CSNK2A1	P68400³, ENSP00000217244⁴	I2D: score=1 STRING: ENSP00000217244
TLE1	Q04724³, ENSP00000365682⁴	I2D: score=3 STRING: ENSP00000365682

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0030154	cell differentiation	IEA	--

HES6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HES6
Search CenterWatch for drugs/clinical trials and news about HES6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HES6 gene (2 alternative transcripts):

NM_001142853.1 NM_018645.4

Unigene Cluster for HES6:

Hairy and enhancer of split 6 (Drosophila)

Hs.42949 [show with all ESTs]

Unigene Representative Sequence: BI552301

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000272937(uc002vxz.3 uc002vya.3) ENST00000409160(uc002vyb.2)

ENST00000409002 ENST00000409182 ENST00000417803 ENST00000409574 ENST00000409356

ENST00000436051 ENST00000450098

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HES6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HES6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HES6
		SwitchGear 3'UTR luciferase reporter plasmid: HES6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HES6 (see all 7) OriGene shRNA RFP: HES6 OriGene siRNA: HES6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HES6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HES6 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HES6 (NM_001142853)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HES6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HES6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES6

Additional cDNA sequence:

AB035179.1 AF260237.1 AK293111.1 BC007939.2

9 DOTS entries:

DT.92430558 DT.85104201 DT.100783206 DT.120999447 DT.95306279 DT.85104204 DT.95306280 DT.87046042

DT.95306273

24/204 AceView cDNA sequences (see all 204):

BM824529 BE796220 AA045442 BE795322 BE855679 AI278914 BM015683 AF260237

CR610232 BE855476 AI241958 BM825382 BM789450 AA167753 AA059461 AW249678

AI436215 AW054840 BX332483 AI424469 AI082815 BU944044 BM042089 BM480143

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for HES6 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for HES6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HES6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGCTGCGTG

About this image

HES6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Heart

Limb

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See HES6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HES6

SOURCE GeneReport for Unigene cluster: Hs.42949

SABiosciences Custom PCR Arrays for HES6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HES6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HES6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HES6 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HES6⁶	Uncharacterized protein	30(a)	1 ↔ 1	9(6500226-6502744)
lizard (Anolis carolinensis)	Reptilia	HES6⁶	--	55(a)	1 ↔ 1	3(28070611-28075541)
African clawed frog (Xenopus laevis)	Amphibia	Xl.209²	Xenopus laevis cDNA clone 10C6	77.63(n)		AJ009284.1
zebrafish (Danio rerio)	Actinopterygii	hes6²	hairy and enhancer of split 6 (Drosophila)	73.57(n)		373116 BC062387.1
fruit fly (Drosophila melanogaster)	Insecta	HLHmdelta⁶ HLHm7⁶ (see all 8)	E(spl) region transcript m7 (see all 8)	28(a) 26(a) (see all 8)	1 ↔ many 1 ↔ many (see all 8)	3R(21823343-21824355) 3R(21862760-21863741)
worm (Caenorhabditis elegans)	Secernentea	lin-22⁶	abnormal cell LINeage family member (lin-22)	20(a)	1 ↔ 1	IV(3019738-3022213)

ENSEMBL Gene Tree for HES6 (if available)
TreeFam Gene Tree for HES6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HES6 gene

HEYL² HES4² HELT² HEY2² HES7² HES3² HEY1² HES5²

HES2² HES1²

3 SIMAP similar genes for HES6 using alignment to 7 protein entries: HES6_HUMAN (see all proteins):

HES2 HES4 HES1

HES6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79588122^1,2	F,	--	239146475(+)	`CACAAG/ATAGAC`	2	--	ds500¹		1		WA	118
rs192199058^1,2		--	239146515(+)	`AAACAG/TGTCTT`	2	--	ds500¹		0	--	--	--	--
rs139607080^1,2		--	239146516(+)	`AACAGA/GTCTTT`	2	--	ds500¹		0	--	--	--	--
rs72976098^1,2	C,	--	239146661(+)	`ACAAAC/ATCCTT`	2	--	ds500¹		3		NA EA	242
rs72976099^1,2	C,	--	239146778(+)	`CACCAT/CCACAC`	2	--	ds500¹		3		NA EA	242
rs13425949^1,2	C	--	239146869(+)	`ATTTAC/AATATC`	2	--	ds500¹		1		NA	2
rs115599911^1,2		--	239146948(+)	`TAAAAT/CTGTCA`	2	--	ut3¹		1		WA	118
rs8835^1,2	C,	--	239147036(+)	`CAGCTC/GAGTGC`	2	--	ut3¹		6		MN NA CSA EA	615
rs7240^1,2	C,F,A,H,	--	239147129(+)	`CCATTT/CCTGCC`	2	--	ut3¹		18		MN NS EA WA NA CSA	1153
rs1550377^1,2		--	239147152(-)	`GTGCGG/CGCTCT`	2	--	ut3¹		5		MN EA NA WA	358

HapMap Linkage Disequilibrium report for HES6 (239146908 - 239149303 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HES6
1 CNV: 68269
Human Gene Mutation Database (HGMD): HES6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HES6

DNA2.0 Custom Variant and Variant Library Synthesis for HES6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HES6 for disorders           About GeneDecksing

OMIM gene information: 610331    OMIM disorders: --

9 diseases for HES6:    About MalaCards

autism spectrum disorder mood disorder parkinson's disease colon carcinoma

breast cancer retinitis carcinoma leukemia

neuronitis

3 Novoseek disease relationships for HES6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic cancer	31.5	2	17611704 (1)
brain tumors	30.8	1	17611704 (1)
tumors	0	1	17611704 (1)

Human Genome Epidemiology (HuGE) Navigator: HES6 (2 documents)

Export disorders for HES6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HES6 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with HES6)

Utopia: connect your pdf to the dynamic
world of online information

The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. (PubMed id 10851137)^{1, 2, 3, 9} Bae S.-K.... Kageyama R. (2000)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors. (PubMed id 11044617)^{1, 2} Vasiliauskas D. and Stern C.D. (2000)
Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. (PubMed id 12972610)^{1, 9} Gratton M.O....Stifani S. (2003)
Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PubMed id 17611704)^{1, 9} Katoh M. and Katoh M. (2007)
HES6 enhances the motility of alveolar rhabdomyosarcom a cells. (PubMed id 22982728)¹ Wickramasinghe C.M....Jones P.H. (2013)
SET8 promotes epithelial-mesenchymal transition and co nfers TWIST dual transcriptional activities. (PubMed id 21983900)¹ Yang F....Shang Y. (2012)
HES6 gene is selectively overexpressed in glioma and r epresents an important transcriptional regulator of glioma proliferation. (PubMed id 21785461)¹ Haapa-Paananen S....Kallioniemi O. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55502	HGNC: 18254	AceView: HES6	Ensembl:ENSG00000144485	euGenes: HUgn55502
ECgene: HES6	H-InvDB: HES6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HES6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HES6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HES6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HES6 gene:
Search GeneIP for patents involving HES6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for HES6		OriGene shRNA RFP for HES6
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HES6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HES6
	OriGene Protein Over-expression Lysate for HES6		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HES6		OriGene 3'-UTR Clone for HES6
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HES6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HES6
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HES6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HES6		OriGene Custom Protein Services for HES6
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HES6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HES6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES6

	GenScript Custom Purified and Recombinant Proteins Services for HES6		GenScript cDNA clones with any tag delivered in your preferred vector for HES6
	GenScript Custom Assay Services for HES6		GenScript Custom Superior Antibodies Services for HES6
	GenScript Custom overexpressing Cell Line Services for HES6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HES6 promoter
	Search Chromatin IP Primers for HES6
	RT² qPCR Primer Assay in human, mouse, rat HES6
	GNC Network for HES6
	SABiosciences Custom PCR Arrays for HES6

Search Tocris compounds for HES6

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HES6 antibodies
	HES6 proteins
	HES6 lysates

	Search for Antibodies for HES6 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HES6
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HES6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HES6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES6

	SwitchGear 3'UTR luciferase reporter plasmids for HES6
	SwitchGear Promoter luciferase reporter plasmids for HES6

ThermoFisher Antibodies for HES6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES6

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HES6 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HES6 Gene

hairy and enhancer of split 6 (Drosophila)

Aliases
for HES6 gene

Summaries
for HES6 gene

Genomic Views
for HES6 gene

Proteins
for HES6 gene

Protein Domains /
Families
for HES6 gene

Function
for HES6 gene

Pathways & Interactions
for HES6 gene

Drugs & Compounds
for HES6 gene

Transcripts
for HES6 gene

Expression
for HES6 gene

Orthologs
for HES6 gene

Paralogs
for HES6 gene

Genomic Variants
for HES6 gene

Disorders / Diseases
for HES6 gene

Publications
for HES6 gene

External Searches for HES6 gene

Genome Databases showing HES6 gene

Other Databases showing HES6 gene

Specialized Databases showing HES6 gene

Intellectual Property
for HES6 gene

Products
for HES6 gene

View Random Gene

Advanced Search

Export list of displayed genes

HES6 Gene

hairy and enhancer of split 6 (Drosophila)

Aliasesfor HES6 gene

Summariesfor HES6 gene

Genomic Viewsfor HES6 gene

Proteinsfor HES6 gene

Protein Domains /Familiesfor HES6 gene

Functionfor HES6 gene

Pathways & Interactionsfor HES6 gene

Drugs & Compoundsfor HES6 gene

Transcriptsfor HES6 gene

Expression for HES6 gene

Orthologsfor HES6 gene

Paralogsfor HES6 gene

Genomic Variantsfor HES6 gene

Disorders / Diseasesfor HES6 gene

Publicationsfor HES6 gene

External Searches for HES6 gene

Genome Databases showing HES6 gene

Other Databases showing HES6 gene

Specialized Databases showing HES6 gene

Intellectual Propertyfor HES6 gene

Productsfor HES6 gene

View Random Gene

Aliases
for HES6 gene

Summaries
for HES6 gene

Genomic Views
for HES6 gene

Proteins
for HES6 gene

Protein Domains /
Families
for HES6 gene

Function
for HES6 gene

Pathways & Interactions
for HES6 gene

Drugs & Compounds
for HES6 gene

Transcripts
for HES6 gene

Expression
for HES6 gene

Orthologs
for HES6 gene

Paralogs
for HES6 gene

Genomic Variants
for HES6 gene

Disorders / Diseases
for HES6 gene

Publications
for HES6 gene

Intellectual Property
for HES6 gene

Products
for HES6 gene