Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HES6 Gene

protein-coding   GIFtS: 59
GCID: GC02M239187

Hairy And Enhancer Of Split 6 (Drosophila)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hairy And Enhancer Of Split 6 (Drosophila)1 2     bHLHc232
Class B Basic Helix-Loop-Helix Protein 412 3     Transcription Cofactor HES-62
C-HAIRY12 3     BHLHB413
bHLHb412 3     Hairy And Enhancer Of Split 63
HES-62     

External Ids:    HGNC: 182541   Entrez Gene: 555022   Ensembl: ENSG000001444857   OMIM: 6103315   UniProtKB: Q96HZ43   

Export aliases for HES6 gene to outside databases

Previous GC identifers: GC02M237195 GC02M237828 GC02M239163 GC02M239433 GC02M238928 GC02M238812 GC02M230937 GC02M239166 GC02M239172


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HES6 Gene:
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to
the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous
cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription
factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding
different isoforms have been described.(provided by RefSeq, Dec 2008)

GeneCards Summary for HES6 Gene: 
HES6 (hairy and enhancer of split 6 (Drosophila)) is a protein-coding gene. Diseases associated with HES6 include autism spectrum disorder, and mood disorder, and among its related super-pathways are Notch signaling pathway. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4
Function: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression
and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by
ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell
differentiation (By similarity)

Gene Wiki entry for HES6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005120.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HES6 gene promoter:
         Nkx3-1   Elk-1   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHES6 promoter sequence
   Search SABiosciences Chromatin IP Primers for HES6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

HES6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M239187:  view genomic region     (about GC identifiers)

Start:
239,146,908 bp from pter      End:
239,149,303 bp from pter
Size:
2,396 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4 (See protein sequence)
Recommended Name: Transcription cofactor HES-6  
Size: 224 amino acids; 24129 Da
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE
family. Interacts with HES1 (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: A8KAP6 Q53SN9 Q8N2J2 Q96T93 Q9P2S3
Alternative splicing: 3 isoforms:  Q96HZ4-1   Q96HZ4-2   Q96HZ4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HES6: NX_Q96HZ4

Explore proteomics data for HES6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96HZ4

  • HES6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HES6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001136325.1  NP_001269363.1  NP_061115.2  

    ENSEMBL proteins: 
     ENSP00000272937   ENSP00000387215   ENSP00000387155   ENSP00000387343   ENSP00000401797  
     ENSP00000387008   ENSP00000387107   ENSP00000392596   ENSP00000390870  

    Human Recombinant Protein Products for HES6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HES6
    OriGene Protein Over-expression Lysate for HES6
    OriGene MassSpec for HES6 
    OriGene Custom Protein Services for HES6
    GenScript Custom Purified and Recombinant Proteins Services for HES6
    Novus Biologicals HES6 Protein
    Novus Biologicals HES6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HES6 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex ISS10851137

    HES6 for ontologies           About GeneDecksing



    HES6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HES6
    OriGene Custom Antibody Services for HES6
    GenScript Custom Superior Antibodies Services for HES6
    Novus Biologicals HES6 Antibodies
    Abcam antibodies for HES6
    Cloud-Clone Corp. Antibodies for HES6 
    ThermoFisher Antibodies for HES6
    LSBio Antibodies in human, mouse, rat for HES6 

    Assay Products for HES6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HES6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HES6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HES6 
    Cloud-Clone Corp. CLIAs for HES6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR003650 Orange
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q96HZ4

    ProtoNet protein and cluster: Q96HZ4

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB003650 Orange


    UniProtKB/Swiss-Prot: HES6_HUMAN, Q96HZ4
    Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with
    Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related
    proteins (By similarity)
    Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box
    (CACNAG), rather than the canonical E-box (CANNTG)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 Orange domain


    HES6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HES6_HUMAN, Q96HZ4
    Function: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression
    and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by
    ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell
    differentiation (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003712transcription cofactor activity ISS10851137
    GO:0008134transcription factor binding NAS17611704
    GO:0046983protein dimerization activity IEA--
         
    HES6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HES6:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HES6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HES6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HES6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HES6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HES6
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HES6
    SwitchGear 3'UTR luciferase reporter plasmidHES6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HES6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HES6
    Sirion Biotech Customized adenovirus for overexpression of HES6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HES6 (see all 13)
    OriGene ORF clones in mouse, rat for HES6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HES6 (NM_001142853)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES6
    Sirion Biotech Customized lentivirus for stable overexpression of HES6 
                         Customized lentivirus expression plasmids for stable overexpression of HES6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HES6
    Search LifeMap BioReagents cell lines for HES6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HES6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway
    Delta-Notch Signaling Pathway0.33
    2Notch-mediated HES/HEY network
    Notch-mediated HES/HEY network


    2 BioSystems Pathways for HES6
        Delta-Notch Signaling Pathway
    Notch-mediated HES/HEY network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HES6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/18 Interacting proteins for HES6 (Q96HZ42, 3 ENSP000002729374) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HES1Q144693, ENSP000002324244I2D: score=2 STRING: ENSP00000232424
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    CSNK2A1P684003, ENSP000002172444I2D: score=1 STRING: ENSP00000217244
    TLE1Q047243, ENSP000003656824I2D: score=3 STRING: ENSP00000365682
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    HES6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HES6

    Search CenterWatch for drugs/clinical trials and news about HES6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HES6 gene (3 alternative transcripts): 
    NM_001142853.2  NM_001282434.1  NM_018645.5  

    Unigene Cluster for HES6:

    Hairy and enhancer of split 6 (Drosophila)
    Hs.42949  [show with all ESTs]
    Unigene Representative Sequence: BI552301
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272937(uc002vxz.3 uc002vya.3) ENST00000409160(uc002vyb.2)
    ENST00000409002 ENST00000409182 ENST00000417803 ENST00000409574 ENST00000409356
    ENST00000436051 ENST00000450098

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HES6
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HES6
    SwitchGear 3'UTR luciferase reporter plasmidHES6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HES6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES6
    Clone
    Products:
         
    OriGene clones in human, mouse for HES6 (see all 13)
    OriGene ORF clones in mouse, rat for HES6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HES6 (NM_001142853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES6
    Sirion Biotech Customized lentivirus for stable overexpression of HES6 
                         Customized lentivirus expression plasmids for stable overexpression of HES6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HES6
    OriGene qSTAR qPCR primer pairs in human, mouse for HES6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HES6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES6

    Additional mRNA sequence: 

    AB035179.1 AF260237.1 AK293111.1 BC007939.2 

    9 DOTS entries:

    DT.92430558  DT.85104201  DT.100783206  DT.120999447  DT.95306279  DT.85104204  DT.95306280  DT.87046042 
    DT.95306273 

    24/204 AceView cDNA sequences (see all 204):

    AW249678 BM825382 BM042089 BX332483 AI278914 BQ682515 BE222726 BM824529 
    AW054840 AA045442 BE795322 BU944044 AA059461 CR610232 AF260237 BM827249 
    BM480143 BM015683 BE796220 BM789450 AI241958 AA167753 AI082815 BE855679 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HES6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
    SP1:                                    
    SP2:                                    
    SP3:                                    


    ECgene alternative splicing isoforms for HES6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HES6 expression in normal human tissues (normalized intensities)      HES6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCTGCGTG
    HES6 Expression
    About this image


    HES6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Globus Pallidus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Human Astrocytes   
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
             sensory organ/ear/inner ear   
     
     Nose (Sensory Organs)    fully expand to see all 4 entries
             sensory organ/nose   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Autopod
             limb/hindlimb   

    See HES6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HES6

    SOURCE GeneReport for Unigene cluster: Hs.42949
        SABiosciences Custom PCR Arrays for HES6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HES6
    OriGene qSTAR qPCR primer pairs in human, mouse for HES6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HES6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HES6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hes61 , 5 hairy and enhancer of split 6 (Drosophila)1, 5 83.93(n)1
    85.71(a)1
      1 (46.12 cM)5
    559271  NM_019479.31  NP_062352.11 
     914114835 
    chicken
    (Gallus gallus)
    Aves HES66
    hairy and enhancer of split 6 (Drosophila)
    24(a)
    1 ↔ 1
    9(4942248-4948675)
    lizard
    (Anolis carolinensis)
    Reptilia HES66
    Uncharacterized protein
    58(a)
    1 ↔ 1
    3(28067051-28075685)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.2092 Xenopus laevis cDNA clone 10C6 77.63(n)    AJ009284.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hes62 hairy and enhancer of split 6 (Drosophila) 73.57(n)   373116  BC062387.1 


    ENSEMBL Gene Tree for HES6 (if available)
    TreeFam Gene Tree for HES6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HES6 gene
    HES42  HES52  HES22  HES12  
    3 SIMAP similar genes for HES6 using alignment to 7 protein entries:     HES6_HUMAN (see all proteins):
    HES2    HES4    HES1

    HES6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/61 SNPs in HES6 are shown (see all 61)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs795881221,2
    F--239146475(+) CACAAG/ATAGAC 2 -- ds50011Minor allele frequency- A:0.10WA 118
    rs1921990581,2
    --239146515(+) AAACAG/TGTCTT 2 -- ds50010--------
    rs1396070801,2
    --239146516(+) AACAGA/GTCTTT 2 -- ds50010--------
    rs729760981,2
    C--239146661(+) ACAAAC/ATCCTT 2 -- ds50013Minor allele frequency- A:0.22NA EA 242
    rs729760991,2
    C,F--239146778(+) CACCAT/CCACAC 2 -- ds50013Minor allele frequency- C:0.23NA EA 242
    rs134259491,2
    C--239146869(+) ATTTAC/AATATC 2 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1155999111,2
    F--239146948(+) TAAAAT/CTGTCA 2 -- ut311Minor allele frequency- C:0.01WA 118
    rs88351,2
    C,F--239147036(+) CAGCTC/GAGTGC 2 -- ut316Minor allele frequency- G:0.39MN NA CSA EA 615
    rs72401,2
    C,F,A,H--239147129(+) CCATTT/CCTGCC 2 -- ut3118Minor allele frequency- C:0.33MN NS EA WA NA CSA 1153
    rs15503771,2
    C,F--239147152(-) GTGCGG/CGCTCT 2 -- ut315Minor allele frequency- C:0.17MN EA NA WA 358

    HapMap Linkage Disequilibrium report for HES6 (239146908 - 239149303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HES6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv21505CNV Loss19812545
    nsv876067CNV Loss21882294


    Human Gene Mutation Database (HGMD): HES6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HES6
    DNA2.0 Custom Variant and Variant Library Synthesis for HES6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610331    OMIM disorders: --

    9 diseases for HES6:    About MalaCards
    autism spectrum disorder    mood disorder    parkinson's disease    retinitis
    pancreatic cancer    breast cancer    neuronitis    pancreatitis
    leukemia


    HES6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for HES6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 31.5 2 17611704 (1)
    brain tumors 30.8 1 17611704 (1)
    tumors 0 1 17611704 (1)

    Genetic Association Database (GAD): HES6
    Human Genome Epidemiology (HuGE) Navigator: HES6 (2 documents)

    Export disorders for HES6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HES6 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with HES6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. (PubMed id 10851137)1, 2, 3, 9 Bae S.-K.... Kageyama R. (2000)
    2. Expression and association analyses of promoter varia nts of the neurogenic gene HES6, a candidate gene for mood disorder susceptibil ity and antidepressant response. (PubMed id 19481584)1, 4 Glubb D.M....Kennedy M.A. (2009)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors. (PubMed id 11044617)1, 2 Vasiliauskas D. and Stern C.D. (2000)
    8. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. (PubMed id 12972610)1, 9 Gratton M.O....Stifani S. (2003)
    9. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PubMed id 17611704)1, 9 Katoh M. and Katoh M. (2007)
    10. HES6 enhances the motility of alveolar rhabdomyosarcom a cells. (PubMed id 22982728)1 Wickramasinghe C.M....Jones P.H. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55502 HGNC: 18254 AceView: HES6 Ensembl:ENSG00000144485 euGenes: HUgn55502
    ECgene: HES6 H-InvDB: HES6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HES6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HES6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HES6 gene:
    Search GeneIP for patents involving HES6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HES6   OriGene RNAi products in human, mouse, rat for HES6  
     OriGene qPCR primer pairs and template standards for HES6   OriGene Protein Over-expression Lysate for HES6  
     OriGene MassSpec something-or-other for HES6   OriGene clones in human, mouse for HES6  
     OriGene qSTAR qPCR primer pairs in human, mouse for HES6   OriGene Purified Protein for HES6  
     OriGene ORF clones in mouse, rat for HES6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HES6   OriGene Custom Protein Services for HES6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HES6
     QIAGEN SeqTarget long-range PCR primers for resequencing HES6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES6
     GenScript Custom Purified and Recombinant Proteins Services for HES6 GenScript cDNA clones with any tag delivered in your preferred vector for HES6
     GenScript Custom Assay Services for HES6 GenScript Custom Superior Antibodies Services for HES6
     GenScript Custom overexpressing Cell Line Services for HES6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HES6 promoter
     Search Chromatin IP Primers for HES6
     RT2 qPCR Primer Assay in human, mouse, rat HES6
     GNC Network for HES6
     SABiosciences Custom PCR Arrays for HES6
     Search Tocris compounds for HES6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HES6 antibodies
     HES6 proteins
     HES6 lysates
     Antibodies for HES6
     See all of Abcam's Antibodies, Kits and Proteins for HES6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HES6
     Antibodies for HES6
     ELISAs for HES6
     CLIAs for HES6
     Search LifeMap BioReagents cell lines for HES6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES6
     SwitchGear 3'UTR luciferase reporter plasmids for HES6
     SwitchGear Promoter luciferase reporter plasmids for HES6
     ThermoFisher Antibodies for HES6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HES6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HES6
    Customized:
     lentivirus for stable overexpression of HES6
     lentivirus expression plasmids for stable overexpression of HES6
     adenovirus for overexpression of HES6
     LSBio Antibodies in human, mouse, rat for HES6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HES6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4