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Aliases for HES5 Gene

Aliases for HES5 Gene

  • Hes Family BHLH Transcription Factor 5 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 38 3 4
  • Hairy And Enhancer Of Split 5 3 4
  • BHLHb38 3 4
  • Hairy And Enhancer Of Split 5 (Drosophila) 2
  • Transcription Factor HES-5 3

External Ids for HES5 Gene

Previous GeneCards Identifiers for HES5 Gene

  • GC01U900022
  • GC01M002495
  • GC01M002450
  • GC01M001739
  • GC01M002460

Summaries for HES5 Gene

Entrez Gene Summary for HES5 Gene

  • This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]

GeneCards Summary for HES5 Gene

HES5 (Hes Family BHLH Transcription Factor 5) is a Protein Coding gene. Diseases associated with HES5 include Valproate Embryopathy, Susceptibility To. Among its related pathways are Signaling by NOTCH1 and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include chromatin binding and protein dimerization activity. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot for HES5 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).

Gene Wiki entry for HES5 Gene

Additional gene information for HES5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES5 Gene

Genomics for HES5 Gene

Regulatory Elements for HES5 Gene

Enhancers for HES5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H001685 1.4 Ensembl ENCODE dbSUPER 5.9 +843.9 843896 2.3 HDGF PKNOX1 KLF17 RARA FOS RCOR1 CEBPB SREBF1 MAFF ZNF589 CDK11B HES5 ANKRD65 GC01M001675 SLC35E2B
GH01H003093 0.4 dbSUPER 5.6 -564.3 -564315 1.8 RING1 ZIC2 MORN1 FAAP20 TP73-AS1 PRDM16 LINC00982 LOC100129534 ENSG00000234396 HES5 PIR58969 MIR4251
GH01H002319 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +208.4 208443 3.8 RFX1 FOS ZIC2 RAD21 PRDM1 NR2F2 TEAD3 ENSG00000272106 PLCH2 LOC100129534 HES5 GC01M002322 PIR31073
GH01H002128 0.5 FANTOM5 dbSUPER 2.8 +401.7 401721 0.1 HES5 GC01M002102 GC01M002070
GH01H002532 1.3 Ensembl ENCODE dbSUPER 0.7 -4.2 -4208 3.3 ESRRA KLF1 NFIB SIN3A KLF17 ZIC2 E2F1 ZFHX2 CTBP1 GLIS2 ENSG00000224387 MMEL1 ENSG00000272449 GC01M002535 HES5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HES5 on UCSC Golden Path with GeneCards custom track

Promoters for HES5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000361 745 201 CTCF RB1 SAP130 SUZ12 NR2F1 ZIC2 NR2F2 KAT8 E2F1 CTBP1

Genomic Locations for HES5 Gene

Genomic Locations for HES5 Gene
1,501 bases
Minus strand

Genomic View for HES5 Gene

Genes around HES5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES5 Gene

Proteins for HES5 Gene

  • Protein details for HES5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor HES-5
    Protein Accession:
    Secondary Accessions:
    • B9DI85

    Protein attributes for HES5 Gene

    166 amino acids
    Molecular mass:
    18226 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

neXtProt entry for HES5 Gene

Post-translational modifications for HES5 Gene

  • Ubiquitination at posLast=134134
  • Modification sites at PhosphoSitePlus

Other Protein References for HES5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HES5 Gene

Domains & Families for HES5 Gene

Gene Families for HES5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HES5 Gene

Suggested Antigen Peptide Sequences for HES5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
genes like me logo Genes that share domains with HES5: view

Function for HES5 Gene

Molecular function for HES5 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).

Gene Ontology (GO) - Molecular Function for HES5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS,IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003690 double-stranded DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
genes like me logo Genes that share ontologies with HES5: view
genes like me logo Genes that share phenotypes with HES5: view

Animal Models for HES5 Gene

MGI Knock Outs for HES5:

miRNA for HES5 Gene

miRTarBase miRNAs that target HES5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HES5 Gene

Localization for HES5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HES5 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HES5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HES5: view

Pathways & Interactions for HES5 Gene

genes like me logo Genes that share pathways with HES5: view

Gene Ontology (GO) - Biological Process for HES5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0002062 NOT chondrocyte differentiation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006461 protein complex assembly IEA,ISS --
genes like me logo Genes that share ontologies with HES5: view

No data available for SIGNOR curated interactions for HES5 Gene

Drugs & Compounds for HES5 Gene

No Compound Related Data Available

Transcripts for HES5 Gene

mRNA/cDNA for HES5 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HES5 Gene

Hairy and enhancer of split 5 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES5 Gene

No ASD Table

Relevant External Links for HES5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HES5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HES5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Amygdala (x4.4), and Brain - Hypothalamus (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of HES5 Gene:


SOURCE GeneReport for Unigene cluster for HES5 Gene:


mRNA Expression by UniProt/SwissProt for HES5 Gene:

Tissue specificity: Expressed in fetal heart and brain tumors.

Evidence on tissue expression from TISSUES for HES5 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with HES5: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES5 Gene

Orthologs for HES5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HES5 33 34
  • 90.1 (n)
(Pan troglodytes)
Mammalia HES5 33 34
  • 90.1 (n)
(Bos Taurus)
Mammalia HES5 33 34
  • 89.84 (n)
(Rattus norvegicus)
Mammalia Hes5 33
  • 85.14 (n)
(Mus musculus)
Mammalia Hes5 33 16 34
  • 84.74 (n)
(Monodelphis domestica)
Mammalia HES5 34
  • 70 (a)
(Gallus gallus)
Aves HES5 33 34
  • 69.23 (n)
(Anolis carolinensis)
Reptilia HES5 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hes5.1 33
  • 64.12 (n)
Str.11260 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53782 33
(Danio rerio)
Actinopterygii LOC100149066 33
  • 65.25 (n)
her2 34
  • 47 (a)
hes5 33
fruit fly
(Drosophila melanogaster)
Insecta Her 34
  • 26 (a)
E(spl) 34
  • 21 (a)
HLHm7 34
  • 20 (a)
HLHmbeta 34
  • 20 (a)
HLHmdelta 34
  • 20 (a)
HLHmgamma 34
  • 18 (a)
HLHm5 34
  • 17 (a)
HLHm3 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea lin-22 34
  • 21 (a)
Species where no ortholog for HES5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HES5 Gene

Gene Tree for HES5 (if available)
Gene Tree for HES5 (if available)

Paralogs for HES5 Gene

Paralogs for HES5 Gene

(2) SIMAP similar genes for HES5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HES5: view

Variants for HES5 Gene

Sequence variations from dbSNP and Humsavar for HES5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000353942 -- 2,531,307(+) CAGCC(C/T)TAGCC upstream-variant-2KB
rs1000617807 -- 2,530,295(+) ATAGG(A/C)GCGGG upstream-variant-2KB, utr-variant-5-prime
rs1000739681 -- 2,530,375(+) CCGCA(C/G)AAAGG upstream-variant-2KB, utr-variant-5-prime
rs1001619656 -- 2,529,347(+) CAGAG(C/G)CTTCC utr-variant-3-prime
rs1002738976 -- 2,528,617(+) GGGTC(C/T)AGGGG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HES5 Gene

Variant ID Type Subtype PubMed ID
nsv951557 CNV deletion 24416366
nsv824031 CNV gain 20364138
nsv823920 CNV gain 20364138
nsv818222 CNV loss 17921354
nsv7171 OTHER inversion 18451855
nsv545080 CNV loss 21841781
nsv545077 CNV gain 21841781
nsv545076 CNV gain 21841781
nsv470684 CNV loss 18288195
nsv1 OTHER inversion 15895083

Variation tolerance for HES5 Gene

Gene Damage Index Score: 1.84; 34.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HES5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES5 Gene

Disorders for HES5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HES5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
valproate embryopathy, susceptibility to
  • fetal valproate syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HES5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HES5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HES5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HES5 Gene

Publications for HES5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M … Katoh M (International journal of oncology 2004) 3 4 60
  3. HES5 promotes cellular proliferation of non-small cell lung cancer through STAT3 signaling. (PMID: 27878283) Gu S … Wu C (Oncology reports 2017) 3 60
  4. HES5 silencing is an early and recurrent change in prostate tumourigenesis. (PMID: 25560400) Massie CE … Lynch AG (Endocrine-related cancer 2015) 3 60
  5. HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma. (PMID: 26342546) Zhu G … Cheng C (Experimental and molecular pathology 2015) 3 60

Products for HES5 Gene

Sources for HES5 Gene

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