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Aliases for HES5 Gene

Aliases for HES5 Gene

  • Hes Family BHLH Transcription Factor 5 2 3
  • Class B Basic Helix-Loop-Helix Protein 38 3 4
  • Hairy And Enhancer Of Split 5 3 4
  • BHLHb38 3 4
  • Hairy And Enhancer Of Split 5 (Drosophila) 2
  • Transcription Factor HES-5 3

External Ids for HES5 Gene

Previous GeneCards Identifiers for HES5 Gene

  • GC01U900022
  • GC01M002495
  • GC01M002450
  • GC01M001739
  • GC01M002460

Summaries for HES5 Gene

Entrez Gene Summary for HES5 Gene

  • This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]

GeneCards Summary for HES5 Gene

HES5 (Hes Family BHLH Transcription Factor 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and protein dimerization activity. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot for HES5 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).

Gene Wiki entry for HES5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES5 Gene

Genomics for HES5 Gene

Regulatory Elements for HES5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HES5 Gene

2,528,745 bp from pter
2,530,245 bp from pter
1,501 bases
Minus strand

Genomic View for HES5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HES5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES5 Gene

Proteins for HES5 Gene

  • Protein details for HES5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor HES-5
    Protein Accession:
    Secondary Accessions:
    • B9DI85

    Protein attributes for HES5 Gene

    166 amino acids
    Molecular mass:
    18226 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

neXtProt entry for HES5 Gene

Proteomics data for HES5 Gene at MOPED

Post-translational modifications for HES5 Gene

  • Ubiquitination at Lys134
  • Modification sites at PhosphoSitePlus

Other Protein References for HES5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HES5 Gene

Domains for HES5 Gene

Gene Families for HES5 Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for HES5 Gene

Suggested Antigen Peptide Sequences for HES5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5TA89
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
genes like me logo Genes that share domains with HES5: view

Function for HES5 Gene

Molecular function for HES5 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).

Gene Ontology (GO) - Molecular Function for HES5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003690 double-stranded DNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HES5: view
genes like me logo Genes that share phenotypes with HES5: view

Animal Models for HES5 Gene

MGI Knock Outs for HES5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HES5 Gene

Localization for HES5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES5 Gene

Subcellular locations from

Jensen Localization Image for HES5 Gene COMPARTMENTS Subcellular localization image for HES5 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for HES5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HES5: view

Pathways for HES5 Gene

genes like me logo Genes that share pathways with HES5: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HES5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0002062 NOT chondrocyte differentiation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006461 protein complex assembly ISS --
genes like me logo Genes that share ontologies with HES5: view

Transcripts for HES5 Gene

mRNA/cDNA for HES5 Gene

(14) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HES5 Gene

Hairy and enhancer of split 5 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HES5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES5 Gene

No ASD Table

Relevant External Links for HES5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HES5 Gene

mRNA expression in normal human tissues for HES5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.8), Brain - Amygdala (4.4), and Brain - Hypothalamus (4.1).

SOURCE GeneReport for Unigene cluster for HES5 Gene Hs.57971

mRNA Expression by UniProt/SwissProt for HES5 Gene

Tissue specificity: Expressed in fetal heart and brain tumors.
genes like me logo Genes that share expressions with HES5: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for HES5 Gene

Orthologs for HES5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HES5 35
  • 89.84 (n)
  • 90.85 (a)
HES5 36
  • 93 (a)
(Canis familiaris)
Mammalia HES5 35
  • 90.1 (n)
  • 90.3 (a)
HES5 36
  • 92 (a)
(Mus musculus)
Mammalia Hes5 35
  • 84.74 (n)
  • 83.73 (a)
Hes5 16
Hes5 36
  • 92 (a)
(Pan troglodytes)
Mammalia HES5 35
  • 90.1 (n)
  • 86.67 (a)
HES5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hes5 35
  • 85.14 (n)
  • 83.73 (a)
(Monodelphis domestica)
Mammalia HES5 36
  • 70 (a)
(Gallus gallus)
Aves HES5 35
  • 69.23 (n)
  • 66.03 (a)
HES5 36
  • 66 (a)
(Anolis carolinensis)
Reptilia HES5 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hes5 35
  • 64.12 (n)
  • 63.56 (a)
Str.11260 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53782 35
(Danio rerio)
Actinopterygii hes5 35
LOC100149066 35
  • 65.25 (n)
  • 58.51 (a)
her2 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta E(spl) 36
  • 21 (a)
Her 36
  • 26 (a)
HLHm3 36
  • 15 (a)
HLHm5 36
  • 17 (a)
HLHm7 36
  • 20 (a)
HLHmbeta 36
  • 20 (a)
HLHmdelta 36
  • 20 (a)
HLHmgamma 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea lin-22 36
  • 21 (a)
Species with no ortholog for HES5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HES5 Gene

Gene Tree for HES5 (if available)
Gene Tree for HES5 (if available)

Paralogs for HES5 Gene

Paralogs for HES5 Gene

Selected SIMAP similar genes for HES5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HES5: view

Variants for HES5 Gene

Sequence variations from dbSNP and Humsavar for HES5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2494603 -- 2,531,379(+) CTGAG(C/T)GCCCG upstream-variant-2KB
rs10910087 -- 2,531,396(+) CTTTG(A/G)GGCAA upstream-variant-2KB
rs11583602 -- 2,531,975(+) TTGAA(A/G)GGGAC upstream-variant-2KB
rs12754187 -- 2,530,095(+) CCGGG(C/G)GAGTC intron-variant
rs34724951 -- 2,528,926(-) TGGCT(-/G)GGGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HES5 Gene

Variant ID Type Subtype PubMed ID
dgv64n71 CNV Loss 21882294
dgv71n71 CNV Loss 21882294
dgv72n71 CNV Loss 21882294
dgv75n71 CNV Loss 21882294
nsv470684 CNV Loss 18288195
dgv79n71 CNV Loss 21882294
dgv81n71 CNV Loss 21882294
nsv871726 CNV Loss 21882294
nsv870655 CNV Loss 21882294
nsv871912 CNV Gain 21882294
nsv871255 CNV Loss 21882294
nsv823920 CNV Gain 20364138
nsv818222 CNV Loss 17921354
nsv7171 OTHER Inversion 18451855
dgv82n71 CNV Loss 21882294
nsv824031 CNV Gain 20364138
dgv83n71 CNV Loss 21882294
dgv84n71 CNV Loss 21882294
nsv1 OTHER Inversion 15895083

Relevant External Links for HES5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES5 Gene

Disorders for HES5 Gene

No disorders were found for HES5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HES5 Gene

Publications for HES5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 3 4
  3. Visualization of embryonic neural stem cells using Hes promoters in transgenic mice. (PMID: 16214363) Ohtsuka T. … McConnell S.K. (Mol. Cell. Neurosci. 2006) 3
  4. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. (PMID: 16365048) Ong C.T. … Kopan R. (J. Biol. Chem. 2006) 3
  5. Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites. (PMID: 16679559) Krizhanovsky V. … Ben-Arie N. (J. Mol. Neurosci. 2006) 23

Products for HES5 Gene

Sources for HES5 Gene

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