Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HES5 Gene

protein-coding   GIFtS: 51
GCID: GC01M002460

Hes Family BHLH Transcription Factor 5

(Previous name: hairy and enhancer of split 5 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hes Family BHLH Transcription Factor 51 2     Hairy And Enhancer Of Split 5 (Drosophila)1
Class B Basic Helix-Loop-Helix Protein 382 3     Transcription Factor HES-52
Hairy And Enhancer Of Split 52 3     BHLHB383
bHLHb382 3     

External Ids:    HGNC: 197641   Entrez Gene: 3885852   Ensembl: ENSG000001979217   OMIM: 6073485   UniProtKB: Q5TA893   

Export aliases for HES5 gene to outside databases

Previous GC identifers: GC01U900022 GC01M002495 GC01M002450 GC01M001739


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HES5 Gene:
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product
of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple
tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and
cancer. (provided by RefSeq, Dec 2008)

GeneCards Summary for HES5 Gene:
HES5 (hes family bHLH transcription factor 5) is a protein-coding gene. Diseases associated with HES5 include osteoarthritis, and hypertension. GO annotations related to this gene include chromatin binding and protein dimerization activity. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot: HES5_HUMAN, Q5TA89
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an
important role as neurogenesis negative regulator (By similarity)

Gene Wiki entry for HES5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NT_187515.1  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HES5 gene promoter:
         E2F-3a   E2F   E2F-1   E2F-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHES5 promoter sequence
   Search Chromatin IP Primers for HES5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HES5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.32   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36

HES5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M002460:  view genomic region     (about GC identifiers)

Start:
2,460,184 bp from pter      End:
2,461,684 bp from pter
Size:
1,501 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HES5_HUMAN, Q5TA89 (See protein sequence)
Recommended Name: Transcription factor HES-5  
Size: 166 amino acids; 18226 Da
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE
family (By similarity)
Secondary accessions: B9DI85

Explore the universe of human proteins at neXtProt for HES5: NX_Q5TA89

Explore proteomics data for HES5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys134
  • Modification sites at PhosphoSitePlus

  • See HES5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010926.1  
    ENSEMBL proteins: 
     ENSP00000367714  
    Reactome Protein details: Q5TA89

    HES5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HES5
    OriGene Protein Over-expression Lysate for HES5
    OriGene MassSpec for HES5
    OriGene Custom Protein Services for HES5
    GenScript Custom Purified and Recombinant Proteins Services for HES5
    Novus Biologicals HES5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HES5

    HES5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HES5
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HES5
    OriGene Custom Antibody Services for HES5
    Novus Biologicals HES5 Antibodies
    Search for Antibodies for HES5 at Abcam
    Cloud-Clone Corp. Antibodies for HES5
    Search ThermoFisher Antibodies for HES5
    LSBio Antibodies in human, mouse, rat for HES5

    HES5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HES5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HES5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HES5
    Cloud-Clone Corp. CLIAs for HES5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR003650 Orange
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q5TA89

    ProtoNet protein and cluster: Q5TA89

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB003650 Orange


    UniProtKB/Swiss-Prot: HES5_HUMAN, Q5TA89
    Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box
    (CACNAG), rather than the canonical E-box (CANNTG) (By similarity)
    Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with
    Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related
    proteins (By similarity)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 Orange domain


    HES5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HES5_HUMAN, Q5TA89
    Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an
    important role as neurogenesis negative regulator (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003690double-stranded DNA binding IEA--
    GO:0005515protein binding ----
         
    HES5 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hes5):
     cellular  craniofacial  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  mortality/aging  nervous system  no phenotypic analysis  respiratory system 
     taste/olfaction  vision/eye 

    HES5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hes5tm1Fgu for HES5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HES5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HES5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HES5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HES5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HES5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HES5 (see all 16):
    hsa-miR-676 hsa-miR-376b hsa-miR-4251 hsa-miR-219-5p hsa-miR-500a hsa-miR-3921 hsa-miR-501-5p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidHES5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HES5
    Predesigned siRNA for gene silencing in human, mouse, rat HES5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HES5

    Clone
    Products:
         
    OriGene clones in human, mouse for HES5 (see all 6)
    OriGene ORF clones in mouse, rat for HES5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HES5 (NM_001010926)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HES5
    Browse ESI BIO Cell Lines and PureStem Progenitors for HES5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HES5_HUMAN, Q5TA89: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005654nucleoplasm TAS--

    HES5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HES5 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Signaling by NOTCH2
    Signaling by NOTCH20.67
    NOTCH2 intracellular domain regulates transcription0.00
    4Signaling by GPCR
    Signal Transduction0.58
    5CDC42 signaling events
    CDC42 signaling events0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for HES5
        Notch Signaling Pathway
    SIDS Susceptibility Pathways
    Neural Crest Differentiation
    Delta-Notch Signaling Pathway
    CDC42 signaling events

    4 Reactome Pathways for HES5
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    NOTCH2 intracellular domain regulates transcription
    Constitutive Signaling by NOTCH1 PEST Domain Mutants


    1 Kegg Pathway  (Kegg details for HES5):
        Notch signaling pathway


    HES5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HES5: 
              Notch Signaling Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HES5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for HES5 (Q5TA893 ENSP000003677144) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCL1P505533, ENSP000002667444I2D: score=1 STRING: ENSP00000266744
    JAK2O606743, ENSP000003710674I2D: score=2 STRING: ENSP00000371067
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    CREBBPENSP000002623674STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0002062NOT chondrocyte differentiation ISS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006461protein complex assembly ISS--
    GO:0007155cell adhesion ISS--

    HES5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HES5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HES5 gene: 
    NM_001010926.3  

    Unigene Cluster for HES5:

    Hairy and enhancer of split 5 (Drosophila)
    Hs.57971  [show with all ESTs]
    Unigene Representative Sequence: NM_001010926
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000378453(uc001ajn.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HES5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HES5 (see all 16):
    hsa-miR-676 hsa-miR-376b hsa-miR-4251 hsa-miR-219-5p hsa-miR-500a hsa-miR-3921 hsa-miR-501-5p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidHES5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HES5
    Predesigned siRNA for gene silencing in human, mouse, rat HES5
    Clone
    Products:
         
    OriGene clones in human, mouse for HES5 (see all 6)
    OriGene ORF clones in mouse, rat for HES5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HES5 (NM_001010926)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HES5
    OriGene qSTAR qPCR primer pairs in human, mouse for HES5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HES5
      QuantiTect SYBR Green Assays in human, mouse, rat HES5
      QuantiFast Probe-based Assays in human, mouse, rat HES5

    Additional mRNA sequence: DQ272660.1 

    2 DOTS entries:

    DT.99978174  DT.404795 

    14 AceView cDNA sequences:

    BX104111 CD672134 AA330877 AI869503 AW071837 AW136641 CD672133 AW079166 
    BX441713 AW072004 W68668 BQ924744 W68771 BM724857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HES5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAAAGGC
    HES5 Expression
    About this image


    HES5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Early Retinal Progenitor Cells Retinal Neuroblastic Layer
             Retina
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Pre-myelinating Oligodendrocyte Cells Spinal Cord White Matter
             Cerebral Cortex
             B27-induced oligodendrocyte-like cells
     
     Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    HES5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HES5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.57971

    UniProtKB/Swiss-Prot: HES5_HUMAN, Q5TA89
    Tissue specificity: Expressed in fetal heart and brain tumors

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HES5: 
              Notch Signaling Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HES5
    OriGene qSTAR qPCR primer pairs in human, mouse for HES5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HES5
    QuantiTect SYBR Green Assays in human, mouse, rat HES5
    QuantiFast Probe-based Assays in human, mouse, rat HES5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HES5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hes51 , 5 hairy and enhancer of split 5 (Drosophila)1, 5 84.74(n)1
    83.73(a)1
      4 (86.01 cM)5
    152081  NM_010419.41  NP_034549.11 
     1549609235 
    chicken
    (Gallus gallus)
    Aves HES51 hairy and enhancer of split 5 (Drosophila) 69.23(n)
    66.03(a)
      419392  NM_001012695.1  NP_001012713.1 
    lizard
    (Anolis carolinensis)
    Reptilia HES56
    hes family bHLH transcription factor 5
    56(a)
    1 ↔ 1
    AAWZ02040866(817-2763)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537822 similar to enhancer of split related 74.35(n)    AF383157.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hes52 hairy and enhancer of split 5 (Drosophila) 81.37(n)   359836  AY264404.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Her6
    E(spl)6
    (see all 8)
    Enhancer of split
    (see all 8)
    26(a)
    21(a)
    (see all 8)
    1 ↔ many
    1 ↔ many
    (see all 8)
    X(18098436-18099177)
    3R(21865977-21866640)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-226
    Protein LIN-22 (lin-22) mRNA, complete cds
    21(a)
    1 ↔ 1
    IV(3019740-3022215) WBGene00003008


    ENSEMBL Gene Tree for HES5 (if available)
    TreeFam Gene Tree for HES5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HES5 gene
    HES42  HES62  HES22  HES12  
    2 SIMAP similar genes for HES5 using alignment to 2 protein entries:     HES5_HUMAN (see all proteins):
    HEYL    HES2

    HES5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HES5 (see all 58)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876607791,2
    --2460164(+) GTGAGA/GCACAG 1 -- ds50010--------
    rs1392536621,2
    --2460175(+) CAGACG/TACACT 1 -- ds50010--------
    rs1915281561,2
    --2460215(+) TATGGC/TGGCTT 1 -- ut310--------
    rs1826114111,2
    --2460232(+) AGTCCC/TGTGGC 1 -- ut310--------
    rs1873152851,2
    C--2460428(+) CGCCCA/GTCCGG 1 -- ut310--------
    rs1416006901,2
    C--2460465(+) CAGCTC/TGAGTT 1 -- ut310--------
    rs1156388311,2
    C,F--2460564(+) ACAGGC/TTGGGG 1 -- ut311Minor allele frequency- T:0.03NA 120
    rs726446581,2
    C,F--2460608(+) CATAGA/GACCCC 1 -- ut311Minor allele frequency- G:0.10NA 120
    rs1470678751,2
    --2460896(+) CCGCAA/GGTCCC 1 -- ut310--------
    rs1118164181,2
    C--2461172(+) GGGCCG/TGCGGC 2 A syn11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for HES5 (2460184 - 2461684 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HES5 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv84n71CNV Loss21882294
    nsv871726CNV Loss21882294
    dgv79n71CNV Loss21882294
    dgv72n71CNV Loss21882294
    dgv81n71CNV Loss21882294
    dgv83n71CNV Loss21882294
    nsv818222CNV Loss17921354
    nsv871255CNV Loss21882294
    dgv71n71CNV Loss21882294
    dgv75n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HES5
    DNA2.0 Custom Variant and Variant Library Synthesis for HES5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607348    OMIM disorders: --

    8 diseases for HES5:    
    About MalaCards
    osteoarthritis    hypertension    cervicitis    retinitis
    adenocarcinoma    neuronitis    cerebritis    endotheliitis


    HES5 for disorders           About GeneDecksing


    Export disorders for HES5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HES5 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with HES5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PubMed id 15254753)1, 2 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    3. Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia. (PubMed id 23637910)1 Kuang S.Q....Garcia-Manero G. (PLoS ONE 2013)
    4. Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. (PubMed id 23776410)1 Sancho R....Behrens A. (PLoS Biol. 2013)
    5. Immunohistochemical expression of Notch signaling in the lining epithelium of periapical cysts. (PubMed id 21238798)1 Meliou E....Kiaris H. (J Endod 2011)
    6. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (amp 2011)
    7. Hes1/Hes5 gene inhibits differentiation via down-regulating Hash1 and promotes proliferation in cervical carcinoma cells. (PubMed id 21495212)1 Liu J....Xie X. (Int. J. Gynecol. Cancer 2010)
    8. The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study. (PubMed id 20091184)1 Wang X....Xie X. (J. Cancer Res. Clin. Oncol. 2010)
    9. Notch3 signaling promotes the development of pulmonary arterial hypertension. (PubMed id 19855400)1 Li X....Thistlethwaite P.A. (Nat. Med. 2009)
    10. Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells. (PubMed id 19682396)1 Woo S.M....Kang Y.K. (BMC Neurosci 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 388585 HGNC: 19764 AceView: LOC388585 Ensembl:ENSG00000197921 euGenes: HUgn388585
    ECgene: HES5 Kegg: 388585 H-InvDB: HES5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HES5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HES5 gene:
    Search GeneIP for patents involving HES5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HES5
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HES5   OriGene RNAi products in human, mouse, rat for HES5  
     OriGene qPCR primer pairs and template standards for HES5   OriGene Protein Over-expression Lysate for HES5  
     OriGene MassSpec something-or-other for HES5   OriGene clones in human, mouse for HES5  
     OriGene qSTAR qPCR primer pairs in human, mouse for HES5   OriGene Purified Protein for HES5  
     OriGene ORF clones in mouse, rat for HES5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HES5   OriGene Custom Protein Services for HES5  

     
     
     Block miRNA regulation of human, mouse, rat HES5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HES5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HES5 Predesigned siRNA for gene silencing in human, mouse, rat HES5
     QuantiFast Probe-based Assays in human, mouse, rat HES5 QuantiTect SYBR Green Assays in human, mouse, rat HES5
     PCR Arrays including human, mouse, rat HES5 Search Chromatin IP Primers for HES5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HES5  GeneGlobe Interaction Network for HES5
     Regulatory tfbs in HES5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HES5 GenScript cDNA clones with any tag delivered in your preferred vector for HES5
     GenScript Custom Assay Services for HES5 GenScript Custom overexpressing Cell Line Services for HES5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HES5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HES5 antibodies
     HES5 lysates
     Search for Antibodies for HES5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HES5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HES5
     Antibodies for HES5
     ELISAs for HES5
     CLIAs for HES5



     Browse ESI BIO Cell Lines and PureStem Progenitors for HES5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES5
     SwitchGear 3'UTR luciferase reporter plasmids for HES5
     SwitchGear Promoter luciferase reporter plasmids for HES5
     Search ThermoFisher Antibodies for HES5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HES5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HES5
     LSBio Antibodies in human, mouse, rat for HES5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HES5 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4