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HES4 Gene(Protein Coding)

Hes Family BHLH Transcription Factor 4

GCID:
GC01M001000
GIFtS:
42
Genes Participants
UDN Logo

Aliases for HES4 Gene

Aliases for HES4 Gene

  • Hes Family BHLH Transcription Factor 4 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 42 3 4
  • Hairy And Enhancer Of Split 4 3 4
  • BHLH Factor Hes4 3 4
  • BHLHb42 3 4
  • HHES4 3 4
  • Hairy And Enhancer Of Split 4 (Drosophila) 2
  • Transcription Factor HES-4 3

External Ids for HES4 Gene

Previous GeneCards Identifiers for HES4 Gene

  • GC01M000974
  • GC01M000924
  • GC01M000206

Summaries for HES4 Gene

GeneCards Summary for HES4 Gene

HES4 (Hes Family BHLH Transcription Factor 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and protein dimerization activity. An important paralog of this gene is HES1.

UniProtKB/Swiss-Prot for HES4 Gene

  • Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES4 Gene

Genomics for HES4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for HES4 Gene


Enhancers around HES4 on UCSC Golden Path with GeneCards custom track

Promoters for HES4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000528874 885 3601 CREB3L1 MLX FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D

Transcription factor binding sites by QIAGEN in the HES4 gene promoter:

Genomic Location for HES4 Gene

Chromosome:
1
Start:
998,962 bp from pter
End:
1,001,285 bp from pter
Size:
2,324 bases
Orientation:
Minus strand

Genomic View for HES4 Gene

Genes around HES4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HES4 Gene

Proteins for HES4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HES4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCC6-HES4_HUMAN
    Recommended name:
    Transcription factor HES-4
    Protein Accession:
    Q9HCC6
    Secondary Accessions:
    • Q5SVA5

    Protein attributes for HES4 Gene

    Size:
    221 amino acids
    Molecular mass:
    23523 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

neXtProt entry for HES4 Gene

Post-translational modifications for HES4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HES4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HES4

No data available for DME Specific Peptides for HES4 Gene

Domains & Families for HES4 Gene

Gene Families for HES4 Gene

HGNC:

Protein Domains for HES4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HES4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCC6

UniProtKB/Swiss-Prot:

HES4_HUMAN :
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
Domain:
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
genes like me logo Genes that share domains with HES4: view

Function for HES4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HES4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).

Gene Ontology (GO) - Molecular Function for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with HES4: view
genes like me logo Genes that share phenotypes with HES4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES4 Gene

Localization for HES4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES4 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HES4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HES4: view

Pathways & Interactions for HES4 Gene

SuperPathways for HES4 Gene

PathCards logo More details on SuperPathways for HES4
No Data Available

Gene Ontology (GO) - Biological Process for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HES4: view

No data available for Pathways by source and SIGNOR curated interactions for HES4 Gene

Drugs & Compounds for HES4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HES4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HES4 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HES4 Gene

Hairy and enhancer of split 4 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for HES4 Gene

GeneLoc Exon Structure for
HES4
ECgene alternative splicing isoforms for
HES4

Expression for HES4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HES4 Gene

mRNA expression in normal human tissues for HES4 Gene
mRNA expression by BioGPS for HES4 GenemRNA expression by GTEx for HES4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HES4 Gene:

HES4

SOURCE GeneReport for Unigene cluster for HES4 Gene:

Hs.154029
genes like me logo Genes that share expression patterns with HES4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HES4 Gene

Orthologs for HES4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia -- 35
  • 100 (a)
 OneToMany
-- 35
  • 100 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia HES4 35
  • 83 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia HES4 35
  • 77 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia HES4 35
  • 52 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 24 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves -- 35
  • 38 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 49 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii her6 35
  • 47 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta h 35
  • 25 (a)
 ManyToMany
dpn 35
  • 22 (a)
 ManyToMany
Side 35
  • 16 (a)
 ManyToMany
Species where no ortholog for HES4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES4 Gene

ENSEMBL:
Gene Tree for HES4 (if available)
TreeFam:
Gene Tree for HES4 (if available)

Paralogs for HES4 Gene

Paralogs for HES4 Gene

(4) SIMAP similar genes for HES4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HES4: view

Variants for HES4 Gene

Sequence variations from dbSNP and Humsavar for HES4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111418382 -- 999,757(+) CGCTC(A/G)GCGCC intron-variant, reference, stop-gained
rs111758243 -- 1,002,052(+) ATCCC(A/G)GGGGA upstream-variant-2KB
rs112549187 -- 1,002,256(+) GGCCC(A/G)AGACG upstream-variant-2KB
rs113602214 -- 999,666(+) TCCGG(A/G)TCTCG intron-variant
rs114518990 -- 1,001,307(+) AAAGC(A/C)TTCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HES4 Gene

Variant ID Type Subtype PubMed ID
nsv950451 CNV deletion 24416366
nsv832980 CNV gain 17160897
nsv827252 CNV gain 20364138
nsv544895 CNV loss 21841781
nsv517709 CNV gain+loss 19592680
nsv482937 CNV loss 15286789
nsv428334 CNV gain 18775914
nsv1160644 CNV deletion 26073780
nsv10161 CNV gain+loss 18304495
nsv1013524 CNV gain 25217958
esv2762302 CNV gain 21179565
dgv5n100 CNV gain 25217958
dgv2n67 CNV gain 20364138

Variation tolerance for HES4 Gene

Gene Damage Index Score: 7.83; 83.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HES4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HES4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES4 Gene

Disorders for HES4 Gene

Relevant External Links for HES4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HES4

No disorders were found for HES4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES4 Gene

Publications for HES4 Gene

  1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PMID: 11260262) Bessho Y. … Kageyama R. (Genes Cells 2001) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. (PMID: 25480889) Bai G. … Chen J.F. (Hum. Mol. Genet. 2015) 3 64

Products for HES4 Gene

Sources for HES4 Gene

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