Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HES4 Gene

Aliases for HES4 Gene

  • Hes Family BHLH Transcription Factor 4 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 42 3 4
  • Hairy And Enhancer Of Split 4 3 4
  • BHLH Factor Hes4 3 4
  • BHLHb42 3 4
  • HHES4 3 4
  • Hairy And Enhancer Of Split 4 (Drosophila) 2
  • Transcription Factor HES-4 3

External Ids for HES4 Gene

Previous GeneCards Identifiers for HES4 Gene

  • GC01M000974
  • GC01M000924
  • GC01M000206

Summaries for HES4 Gene

GeneCards Summary for HES4 Gene

HES4 (Hes Family BHLH Transcription Factor 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding and protein dimerization activity. An important paralog of this gene is HES1.

UniProtKB/Swiss-Prot for HES4 Gene

  • Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).

Additional gene information for HES4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES4 Gene

Genomics for HES4 Gene

GeneHancer (GH) Regulatory Elements for HES4 Gene

Promoters and enhancers for HES4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I000998 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.8 796 3.8 CLOCK MLX FEZF1 DMAP1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ISG15 HES4 ATAD3B ENSG00000230092 WASH7P INTS11 ENSG00000272512 LINC01786 CCNL2 ENSG00000272455
GH01I001066 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.5 -67.5 -67497 4.6 HDGF PKNOX1 ATF1 ARID4B NEUROD1 SIN3A ZNF48 POLR2B GLIS2 ZNF143 GC01M001069 LOC105378948 ENSG00000272512 RNF223 C1orf159 HES4 ENSG00000237094 LOC100288175
GH01I001061 Enhancer 1.5 Ensembl ENCODE dbSUPER 6.3 -62.3 -62345 4.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 IRF4 SLC30A9 E2F8 ENSG00000273443 ENSG00000272512 RNF223 ENSG00000237094 HES4 AGRN ENSG00000238009 GC01M001069 GC01P001065 LOC100288175
GH01I000919 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.6 +80.9 80894 2.4 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF213 KLF13 DEK ZHX2 REST GC01M000917 LOC100130417 ENSG00000230699 HES4 LINC00115 LOC284600
GH01I000975 Enhancer 1.1 Ensembl ENCODE 5.1 +23.7 23657 4.7 PKNOX1 ATF1 SIN3A ZNF2 ZNF48 GLIS2 ELK1 KLF7 SP3 REST GC01M000971 PERM1 ENSG00000272512 ISG15 LINC01786 ENSG00000240731 HES4 CDK11A PLEKHN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HES4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HES4 gene promoter:

Genomic Locations for HES4 Gene

Genomic Locations for HES4 Gene
2,324 bases
Minus strand

Genomic View for HES4 Gene

Genes around HES4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES4 Gene

Proteins for HES4 Gene

  • Protein details for HES4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor HES-4
    Protein Accession:
    Secondary Accessions:
    • Q5SVA5

    Protein attributes for HES4 Gene

    221 amino acids
    Molecular mass:
    23523 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

neXtProt entry for HES4 Gene

Post-translational modifications for HES4 Gene

No Post-translational modifications

Other Protein References for HES4 Gene

No data available for DME Specific Peptides for HES4 Gene

Domains & Families for HES4 Gene

Gene Families for HES4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HES4 Gene

Suggested Antigen Peptide Sequences for HES4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
genes like me logo Genes that share domains with HES4: view

Function for HES4 Gene

Molecular function for HES4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).

Phenotypes From GWAS Catalog for HES4 Gene

Gene Ontology (GO) - Molecular Function for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with HES4: view
genes like me logo Genes that share phenotypes with HES4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES4 Gene

Localization for HES4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HES4 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HES4: view

Pathways & Interactions for HES4 Gene

SuperPathway Contained pathways
1 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with HES4: view

Pathways by source for HES4 Gene

1 KEGG pathway for HES4 Gene

Gene Ontology (GO) - Biological Process for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HES4: view

No data available for SIGNOR curated interactions for HES4 Gene

Drugs & Compounds for HES4 Gene

No Compound Related Data Available

Transcripts for HES4 Gene

Unigene Clusters for HES4 Gene

Hairy and enhancer of split 4 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -

Relevant External Links for HES4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HES4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HES4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HES4 Gene:


SOURCE GeneReport for Unigene cluster for HES4 Gene:


Evidence on tissue expression from TISSUES for HES4 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with HES4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES4 Gene

Orthologs for HES4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
-- 34
  • 100 (a)
(Canis familiaris)
Mammalia HES4 34
  • 83 (a)
(Bos Taurus)
Mammalia HES4 34
  • 77 (a)
(Monodelphis domestica)
Mammalia HES4 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
(Gallus gallus)
Aves -- 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
(Danio rerio)
Actinopterygii her6 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta h 34
  • 25 (a)
dpn 34
  • 22 (a)
Side 34
  • 16 (a)
Species where no ortholog for HES4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES4 Gene

Gene Tree for HES4 (if available)
Gene Tree for HES4 (if available)

Paralogs for HES4 Gene

Paralogs for HES4 Gene

(4) SIMAP similar genes for HES4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HES4: view

Variants for HES4 Gene

Sequence variations from dbSNP and Humsavar for HES4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000288620 -- 998,942(-) A/G downstream_transcript_variant
rs1000627427 -- 999,719(-) G/A/T coding_sequence_variant, intron_variant, synonymous_variant
rs1001256418 -- 1,000,738(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001724786 -- 1,002,205(-) A/G upstream_transcript_variant
rs1003313473 -- 1,001,951(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HES4 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
dgv5n100 CNV gain 25217958
esv2762302 CNV gain 21179565
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv428334 CNV gain 18775914
nsv482937 CNV loss 15286789
nsv517709 CNV gain+loss 19592680
nsv544895 CNV loss 21841781
nsv827252 CNV gain 20364138
nsv832980 CNV gain 17160897
nsv950451 CNV deletion 24416366

Variation tolerance for HES4 Gene

Gene Damage Index Score: 7.83; 83.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HES4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES4 Gene

Disorders for HES4 Gene

Additional Disease Information for HES4

No disorders were found for HES4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES4 Gene

Publications for HES4 Gene

  1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PMID: 11260262) Bessho Y … Kageyama R (Genes to cells : devoted to molecular & cellular mechanisms 2001) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M … Katoh M (International journal of oncology 2004) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Hes4: A potential prognostic biomarker for newly diagnosed patients with high-grade osteosarcoma. (PMID: 27786411) McManus M … Schadler K (Pediatric blood & cancer 2017) 3 58

Products for HES4 Gene

Sources for HES4 Gene

Loading form....