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HES4 Gene

protein-coding   GIFtS: 46
GCID: GC01M000924

Hes Family BHLH Transcription Factor 4

(Previous name: hairy and enhancer of split 4 (Drosophila))
  See related diseases
at
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Aliases
for HES4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hes Family BHLH Transcription Factor 41 2     hHES42 3
Class B Basic Helix-Loop-Helix Protein 422 3     Hairy And Enhancer Of Split 4 (Drosophila)1
Hairy And Enhancer Of Split 42 3     Transcription Factor HES-42
bHLHb422 3     BHLHB423
BHLH Factor Hes42 3     

External Ids:    HGNC: 241491   Entrez Gene: 578012   Ensembl: ENSG000001882907   OMIM: 6080605   UniProtKB: Q9HCC63   

Export aliases for HES4 gene to outside databases

Previous GC identifers: GC01M000974 GC01M000206


Summaries
for HES4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HES4 Gene:
HES4 (hes family bHLH transcription factor 4) is a protein-coding gene. Diseases associated with HES4 include ascariasis, and trichuriasis. GO annotations related to this gene include protein dimerization activity and transcription factor binding. An important paralog of this gene is HES5.

UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6
Function: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity)




Genomic Views
for HES4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HES4 gene promoter:
         CREB   p53   deltaCREB   MyoD   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HES4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HES4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

HES4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M000924:  view genomic region     (about GC identifiers)

Start:
 934,342 bp from pter      End:
 935,552 bp from pter
Size:
 1,211 bases      Orientation:
 minus strand

Proteins
for HES4 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6 (See protein sequence)
Recommended Name: Transcription factor HES-4  
Size: 221 amino acids; 23523 Da
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE
family (By similarity)
Secondary accessions: Q5SVA5

Explore the universe of human proteins at neXtProt for HES4: NX_Q9HCC6

Explore proteomics data for HES4 at MOPED


See HES4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001135939.1  NP_066993.1  

ENSEMBL proteins: 
 ENSP00000393198   ENSP00000304595   ENSP00000425085  

HES4 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for HES4
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Novus Biologicals HES4 Protein
Novus Biologicals HES4 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for HES4

HES4 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for HES4 (HES-4)
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OriGene Custom Antibody Services for HES4
Novus Biologicals HES4 Antibody
Abcam antibodies for HES4
Cloud-Clone Corp. Antibodies for HES4
Search ThermoFisher Antibodies for HES4
LSBio Antibodies in human, mouse, rat for HES4

HES4 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for HES4
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HES4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HES4
Cloud-Clone Corp. CLIAs for HES4

Domains /
Families
for HES4 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

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bHLH: Basic helix-loop-helix proteins

3 InterPro protein domains:
 IPR018352 Orange_subgr
 IPR003650 Orange
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q9HCC6

ProtoNet protein and cluster: Q9HCC6

2 Blocks protein domains:
IPB001092 Basic helix-loop-helix dimerization domain bHLH
IPB003650 Orange


UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6
Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box
(CACNAG), rather than the canonical E-box (CANNTG) (By similarity)
Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with
Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related
proteins (By similarity)
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
Similarity: Contains 1 Orange domain


HES4 for domains           About GeneDecksing


Function
for HES4 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HES4_HUMAN, Q9HCC6
Function: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0008134transcription factor binding NAS17611704
GO:0046983protein dimerization activity IEA--
     
HES4 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for HES4:
 Decreased Hepatitis C virus re 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HES4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HES4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HES4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HES4

miRNA
Products:    		miRTarBase miRNAs that target HES4:
hsa-mir-423-5p (MIRT038130), hsa-mir-149-5p (MIRT045541)

Block miRNA regulation of human, mouse, rat HES4 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate HES4
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:    		OriGene RNAi products in human, mouse, rat for HES4
Predesigned siRNA for gene silencing in human, mouse, rat HES4

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for HES4

Clone
Products:     		 OriGene clones in human, mouse for HES4 (see all 10)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): HES4 (NM_021170)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for HES4
Browse ESI BIO Cell Lines and PureStem Progenitors for HES4 
In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4


Localization
for HES4 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HES4_HUMAN, Q9HCC6: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

HES4 for ontologies           About GeneDecksing


Pathways & Interactions
for HES4 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HES4
Interactions:

    Search GeneGlobe Interaction Network for HES4

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

Selected Interacting proteins for HES4 (Q9HCC63 ENSP000003931984) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
InteractantInteraction Details
GeneCardExternal ID(s)
PCBD1P614573, ENSP000002992994I2D: score=1 STRING: ENSP00000299299
PCBD2Q9H0N53, ENSP000002549084I2D: score=1 STRING: ENSP00000254908
ATP13A4Q4VNC13I2D: score=1 
CMSS1Q9BQ753I2D: score=1 
COPG2Q9UBF23I2D: score=1 
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--
GO:0007399nervous system development IEA--
GO:0030154cell differentiation IEA--

HES4 for ontologies           About GeneDecksing



Drugs & Compounds
for HES4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HES4



Transcripts
for HES4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HES4 gene (2 alternative transcripts): 
NM_001142467.1  NM_021170.3  

Unigene Cluster for HES4:

Hairy and enhancer of split 4 (Drosophila)
Hs.154029  [show with all ESTs]
Unigene Representative Sequence: BM543941
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000428771(uc001aci.2 uc010nyc.1) ENST00000304952 ENST00000481869
ENST00000484667
miRNA
Products:     		 Block miRNA regulation of human, mouse, rat HES4 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate HES4
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		OriGene RNAi products in human, mouse, rat for HES4
Predesigned siRNA for gene silencing in human, mouse, rat HES4
Clone
Products:     		 OriGene clones in human, mouse for HES4 (see all 10)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): HES4 (NM_021170)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4
Primer
Products:    		OriGene qPCR primer pairs and template standards for HES4
OriGene qSTAR qPCR primer pairs in human, mouse for HES4
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HES4
  QuantiTect SYBR Green Assays in human, mouse, rat HES4
  QuantiFast Probe-based Assays in human, mouse, rat HES4

Additional mRNA sequence: 

AB048791.1 BC012351.1 

8 DOTS entries:

DT.75101873  DT.100860764  DT.92421458  DT.97795287  DT.100830033  DT.121366989  DT.100860763  DT.95374160 

Selected AceView cDNA sequences (see all 65):

BM789724 BU634310 BU622703 BU741558 CB241590 AW630809 BQ072399 BM747954 
BM127944 BQ013563 BM727881 BI763672 AW161193 BF001624 BG325949 BX281754 
BM713553 BM128269 BF001578 BI602134 BX455241 BU633915 BC012351 BI834315 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for HES4    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:              -                           
SP2:              -     -                     
SP3:                                          


ECgene alternative splicing isoforms for HES4

Expression
for HES4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HES4 expression in normal human tissues (normalized intensities)      HES4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGAAGCGGC
HES4 Expression
About this image


HES4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Endoderm (Gastrulation Derivatives)
         Definitive endoderm-like cells
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood
 
 Brain (Nervous System)
         N2/LSB induced-cells
HES4 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

HES4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.154029
    Custom PCR Arrays for HES4
Primer
Products:		OriGene qPCR primer pairs and template standards for HES4
OriGene qSTAR qPCR primer pairs in human, mouse for HES4
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QuantiFast Probe-based Assays in human, mouse, rat HES4
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4

Orthologs
for HES4 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HES4 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
dog
(Canis familiaris)		 Mammalia HES46
 hes family bHLH transcription factor 4
 83(a)
 1 ↔ 1
 5(55972417-56226772)
chicken
(Gallus gallus)		 Aves --
 Uncharacterized protein
 38(a)
 many ↔ many
 9(12410467-12423754)
lizard
(Anolis carolinensis)		 Reptilia --
 --
 49(a)
 many ↔ many
 GL343334.1(1036941-1044433)
zebrafish
(Danio rerio)		 Actinopterygii her66
 hairy-related 6
 47(a)
 many ↔ many
 6(36329655-36331416) ENSDARG00000006514
fruit fly
(Drosophila melanogaster)		 Insecta h6
dpn6
(see all 3)		 deadpan
(see all 3)		 25(a)
22(a)
(see all 3)		 many ↔ many
many ↔ many
(see all 3)		 3L(8668859-8672353)
2R(4116476-4119832)


ENSEMBL Gene Tree for HES4 (if available)
TreeFam Gene Tree for HES4 (if available)

Paralogs
for HES4 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HES4 gene
HES52  HES62  HES22  HES12  
4 SIMAP similar genes for HES4 using alignment to 3 protein entries:     HES4_HUMAN (see all proteins):
HES1    HEYL    HES6    HES3

HES4 for paralogs           About GeneDecksing



Genomic Variants
for HES4 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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1 SNPs for HES4    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 1 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1458975281,2
C--934144(+) GGAGC-/GGAGG 
        GGAGG 		2 -- ds50010--------

HapMap Linkage Disequilibrium report for HES4 (934342 - 935552 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for HES4 (see all 17):    About this table    
Variant IDTypeSubtypePubMed ID
dgv9n71CNV Loss21882294
dgv12n71CNV Loss21882294
dgv10n71CNV Loss21882294
dgv13n71CNV Loss21882294
dgv11n71CNV Loss21882294
nsv871483CNV Loss21882294
nsv871547CNV Loss21882294
nsv428334CNV Gain18775914
nsv832980CNV Gain17160897
dgv2n67CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HES4
DNA2.0 Custom Variant and Variant Library Synthesis for HES4

Disorders / Diseases
for HES4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TryGeneCards Plus		 OMIM gene information: 608060    OMIM disorders: --

3 diseases for HES4:    About MalaCards
ascariasis    trichuriasis    neuronitis


HES4 for disorders           About GeneDecksing


Export disorders for HES4 gene to outside databases

Publications
for HES4 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HES4 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with HES4)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PubMed id 11260262)1, 2, 3 Bessho Y.... Kageyama R. (Genes Cells 2001)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PubMed id 15254753)1, 3 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
  5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
  6. Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. (PubMed id 21666788)1 Reina Ortiz M....Cooper P.J. (PLoS Negl Trop Dis 2011)
  7. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PubMed id 20195357)1 Miyamoto-Sato E....Yanagawa H. (PLoS ONE 2010)
  8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
  9. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PubMed id 17611704)1 Katoh M. and Katoh M. (Int. J. Oncol. 2007)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for HES4 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing HES4 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57801 HGNC: 24149 AceView: Hes4 Ensembl:ENSG00000188290 euGenes: HUgn57801
ECgene: HES4 H-InvDB: HES4

Other Databases showing HES4 gene

(According to HUGE)
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Specialized Databases showing HES4 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HES4 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for HES4 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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TryGeneCards Plus		Patent Information for HES4 gene:
Search GeneIP for patents involving HES4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for HES4 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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TryGeneCards Plus
 
 EMD Millipore genomic analysis products

  
 Antibodies for HES4 (HES-4)   Browse Cell Culture Products  
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HES4  
 OriGene qPCR primer pairs and template standards for HES4   OriGene Protein Over-expression Lysate for HES4  
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 OriGene Custom Antibody Services for HES4   OriGene Custom Protein Services for HES4  

 		 
 Block miRNA regulation of human, mouse, rat HES4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HES4
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HES4 Predesigned siRNA for gene silencing in human, mouse, rat HES4
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 GenScript Custom Purified and Recombinant Proteins Services for HES4 GenScript cDNA clones with any tag delivered in your preferred vector for HES4
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 Search Tocris compounds for HES4
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 HES4 antibodies
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 See all of Abcam's Antibodies, Kits and Proteins for HES4
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 Proteins for HES4
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 Browse ESI BIO Cell Lines and PureStem Progenitors for HES4
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4
 Browse SwitchGear 3'UTR luciferase reporter plasmids for HES4
 Browse SwitchGear Promoter luciferase reporter plasmids for HES4
 Search ThermoFisher Antibodies for HES4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HES4
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HES4
 LSBio Antibodies in human, mouse, rat for HES4
Customized transgenic rodents for:
 Humanization
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 Browse compounds at ApexBio
       
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