Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HES4 Gene

protein-coding   GIFtS: 47
GCID: GC01M000924

Hairy And Enhancer Of Split 4 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hairy And Enhancer Of Split 4 (Drosophila)1 2     hHES42 3
Class B Basic Helix-Loop-Helix Protein 422 3     Transcription Factor HES-42
bHLHb422 3     BHLHB423
BHLH Factor Hes42 3     Hairy And Enhancer Of Split 43

External Ids:    HGNC: 241491   Entrez Gene: 578012   Ensembl: ENSG000001882907   OMIM: 6080605   UniProtKB: Q9HCC63   

Export aliases for HES4 gene to outside databases

Previous GC identifers: GC01M000974 GC01M000206


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HES4 Gene: 
HES4 (hairy and enhancer of split 4 (Drosophila)) is a protein-coding gene. Diseases associated with HES4 include ascariasis, and trichuriasis. GO annotations related to this gene include protein dimerization activity and transcription factor binding. An important paralog of this gene is HES5.

UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6
Function: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HES4 gene promoter:
         CREB   p53   deltaCREB   MyoD   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HES4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

HES4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M000924:  view genomic region     (about GC identifiers)

Start:
934,342 bp from pter      End:
935,552 bp from pter
Size:
1,211 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6 (See protein sequence)
Recommended Name: Transcription factor HES-4  
Size: 221 amino acids; 23523 Da
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE
family (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5SVA5

Explore the universe of human proteins at neXtProt for HES4: NX_Q9HCC6

Explore proteomics data for HES4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCC6

  • HES4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HES4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001135939.1  NP_066993.1  

    ENSEMBL proteins: 
     ENSP00000393198   ENSP00000304595   ENSP00000425085  

    Human Recombinant Protein Products for HES4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HES4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HES4
    GenScript Custom Purified and Recombinant Proteins Services for HES4
    Novus Biologicals HES4 Protein
    Novus Biologicals HES4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HES4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HES4 for ontologies           About GeneDecksing



    HES4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HES4 (HES-4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HES4
    GenScript Custom Superior Antibodies Services for HES4
    Novus Biologicals HES4 Antibody
    Abcam antibodies for HES4
    Cloud-Clone Corp. Antibodies for HES4 
    Search ThermoFisher Antibodies for HES4
    LSBio Antibodies in human, mouse, rat for HES4 

    Assay Products for HES4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HES4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HES4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HES4 
    Cloud-Clone Corp. CLIAs for HES4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR018352 Orange_subgr
     IPR003650 Orange
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCC6

    ProtoNet protein and cluster: Q9HCC6

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB003650 Orange


    UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6
    Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box
    (CACNAG), rather than the canonical E-box (CANNTG) (By similarity)
    Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with
    Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related
    proteins (By similarity)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 Orange domain


    HES4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HES4_HUMAN, Q9HCC6
    Function: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008134transcription factor binding NAS17611704
    GO:0046983protein dimerization activity IEA--
         
    HES4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HES4:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HES4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HES4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HES4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HES4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HES4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HES4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HES4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HES4
    Sirion Biotech Customized adenovirus for overexpression of HES4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HES4 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HES4 (NM_021170)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4
    Sirion Biotech Customized lentivirus for stable overexpression of HES4 
                         Customized lentivirus expression plasmids for stable overexpression of HES4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HES4
    Search LifeMap BioReagents cell lines for HES4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HES4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/12 Interacting proteins for HES4 (Q9HCC63 ENSP000003931984) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBD1P614573, ENSP000002992994I2D: score=1 STRING: ENSP00000299299
    PCBD2Q9H0N53, ENSP000002549084I2D: score=1 STRING: ENSP00000254908
    ATP13A4Q4VNC13I2D: score=1 
    CMSS1Q9BQ753I2D: score=1 
    COPG2Q9UBF23I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    HES4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HES4

    Search CenterWatch for drugs/clinical trials and news about HES4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HES4 gene (2 alternative transcripts): 
    NM_001142467.1  NM_021170.3  

    Unigene Cluster for HES4:

    Hairy and enhancer of split 4 (Drosophila)
    Hs.154029  [show with all ESTs]
    Unigene Representative Sequence: BM543941
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428771(uc001aci.2 uc010nyc.1) ENST00000304952 ENST00000481869
    ENST00000484667
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HES4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HES4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HES4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES4
    Clone
    Products:
         
    OriGene clones in human, mouse for HES4 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HES4 (NM_021170)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4
    Sirion Biotech Customized lentivirus for stable overexpression of HES4 
                         Customized lentivirus expression plasmids for stable overexpression of HES4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HES4
    OriGene qSTAR qPCR primer pairs in human, mouse for HES4
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat HES4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES4

    Additional mRNA sequence: 

    AB048791.1 BC012351.1 

    8 DOTS entries:

    DT.75101873  DT.100860764  DT.92421458  DT.97795287  DT.100830033  DT.121366989  DT.100860763  DT.95374160 

    24/65 AceView cDNA sequences (see all 65):

    BM747954 BU741558 BM127944 AW630809 BQ013563 BU622703 CB241590 BQ072399 
    BM727881 BM789724 BU634310 AW148795 BM128269 BF001578 BI602134 AW513999 
    BI763672 BM713553 BG325949 BI757407 AW161193 NM_021170 BX455241 BX281754 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HES4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:              -                           
    SP2:              -     -                     
    SP3:                                          


    ECgene alternative splicing isoforms for HES4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HES4 expression in normal human tissues (normalized intensities)      HES4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGCGGC
    HES4 Expression
    About this image


    HES4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             N2/LSB induced-cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             Human Hippocampal Astrocytes   
     
     Lung (Respiratory System)
             Human Pulmonary Artery Fibroblasts (HPAF)   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Kidney (Urinary System)
             Human Renal Mesangial Cells (HRMC)   
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells ( Generation of mesendoderm and definitive endoderm...

    See HES4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HES4

    SOURCE GeneReport for Unigene cluster: Hs.154029
        SABiosciences Custom PCR Arrays for HES4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HES4
    OriGene qSTAR qPCR primer pairs in human, mouse for HES4
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat HES4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HES4 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HES46
    HES16
    hairy and enhancer of split 1, (Drosophila)
    46(a)
    34(a)
    1 ↔ 1
    possible ortholog
    21(2803581-2805434)
    9(12410467-12423754)
    lizard
    (Anolis carolinensis)
    Reptilia --
    HES16
    Uncharacterized protein
    47(a)
    39(a)
    possible ortholog
    possible ortholog
    GL343334.1(1036941-1044433)
    GL343538.1(309240-313331)
    zebrafish
    (Danio rerio)
    Actinopterygii her66
    her96
    hairy-related 9
    47(a)
    44(a)
    possible ortholog
    possible ortholog
    6(36329655-36332018)
    23(23693662-23695447)
    fruit fly
    (Drosophila melanogaster)
    Insecta h6
    dpn6
    (see all 3)
    deadpan
    (see all 3)
    22(a)
    15(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3L(8668859-8672353)
    2R(4116476-4119832)
            Species with no ortholog for HES4

    ENSEMBL Gene Tree for HES4 (if available)
    TreeFam Gene Tree for HES4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HES4 gene
    HES52  HES62  HES22  HES12  
    4 SIMAP similar genes for HES4 using alignment to 3 protein entries:     HES4_HUMAN (see all proteins):
    HES1    HEYL    HES6    HES3

    HES4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in HES4 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458975281,2
    C--934144(+) GGAGC-/GGAGG 
            
    GGAGG
    2 -- ds50010--------

    HapMap Linkage Disequilibrium report for HES4 (934342 - 935552 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for HES4 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv9n71CNV Loss21882294
    dgv12n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv13n71CNV Loss21882294
    dgv11n71CNV Loss21882294
    nsv871483CNV Loss21882294
    nsv871547CNV Loss21882294
    nsv428334CNV Gain18775914
    nsv832980CNV Gain17160897
    dgv2n67CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HES4
    DNA2.0 Custom Variant and Variant Library Synthesis for HES4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608060    OMIM disorders: --

    2 diseases for HES4:    About MalaCards
    ascariasis    trichuriasis


    HES4 for disorders           About GeneDecksing


    Export disorders for HES4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HES4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HES4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PubMed id 11260262)1, 2, 3 Bessho Y.... Kageyama R. (2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PubMed id 15254753)1, 3 Katoh M. and Katoh M. (2004)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. Effects of chronic ascariasis and trichuriasis on cyt okine production and gene expression in human blood: a cross-sectional study. (PubMed id 21666788)1 Reina Ortiz M....Cooper P.J. (2011)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    8. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PubMed id 17611704)1 Katoh M. and Katoh M. (2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57801 HGNC: 24149 AceView: Hes4 Ensembl:ENSG00000188290 euGenes: HUgn57801
    ECgene: HES4 H-InvDB: HES4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HES4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HES4 gene:
    Search GeneIP for patents involving HES4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for HES4 (HES-4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HES4  
     OriGene qPCR primer pairs and template standards for HES4   OriGene Protein Over-expression Lysate for HES4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HES4  
     OriGene qSTAR qPCR primer pairs in human, mouse for HES4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HES4   OriGene Custom Protein Services for HES4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HES4
     QIAGEN SeqTarget long-range PCR primers for resequencing HES4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES4
     GenScript Custom Purified and Recombinant Proteins Services for HES4 GenScript cDNA clones with any tag delivered in your preferred vector for HES4
     GenScript Custom Assay Services for HES4 GenScript Custom Superior Antibodies Services for HES4
     GenScript Custom overexpressing Cell Line Services for HES4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HES4 promoter
     Search Chromatin IP Primers for HES4
     Search RT2 qPCR Primer Assays in human, mouse, rat HES4
     Search GNC Networks for HES4
     SABiosciences Custom PCR Arrays for HES4
     Search Tocris compounds for HES4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HES4 antibodies
     HES4 proteins
     HES4 lysates
     Antibodies for HES4
     See all of Abcam's Antibodies, Kits and Proteins for HES4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HES4
     Antibodies for HES4
     ELISAs for HES4
     CLIAs for HES4
     Search LifeMap BioReagents cell lines for HES4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HES4
     Browse SwitchGear Promoter luciferase reporter plasmids for HES4
     Search ThermoFisher Antibodies for HES4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HES4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HES4
    Customized:
     lentivirus for stable overexpression of HES4
     lentivirus expression plasmids for stable overexpression of HES4
     adenovirus for overexpression of HES4
     LSBio Antibodies in human, mouse, rat for HES4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HES4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4