Aliases for HES4 Gene
Aliases for HES4 Gene
External Ids for HES4 Gene
- HGNC: 24149
- Entrez Gene: 57801
- Ensembl: ENSG00000188290
- OMIM: 608060
- UniProtKB: Q9HCC6
Previous GeneCards Identifiers for HES4 Gene
- GC01M000974
- GC01M000924
- GC01M000206
Summaries for HES4 Gene
GeneCards Summary for HES4 Gene
HES4 (Hes Family BHLH Transcription Factor 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and protein dimerization activity. An important paralog of this gene is HES5.
UniProtKB/Swiss-Prot for HES4 Gene
-
Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES4 Gene
Genomics for HES4 Gene
Regulatory Elements for HES4 Gene
Enhancers for HES4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around HES4 on UCSC Golden Path with GeneCards custom track
Promoters for HES4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around HES4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HES4 gene promoter:
Regulatory Element Products
Genomic Location for HES4 Gene
- Chromosome:
- 1
- Start:
- 998,962 bp from pter
- End:
- 1,001,285 bp from pter
- Size:
- 2,324 bases
- Orientation:
- Minus strand
Genomic View for HES4 Gene
Genes around HES4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.33 by Ensembl
- 1p36.33 by Entrez Gene
- 1p36 by HGNC
HES4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HES4 Gene
Proteins for HES4 Gene
-
Protein details for HES4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HCC6-HES4_HUMAN
- Recommended name:
- Transcription factor HES-4
- Protein Accession:
- Q9HCC6
- Q5SVA5
Protein attributes for HES4 Gene
- Size:
- 221 amino acids
- Molecular mass:
- 23523 Da
- Quaternary structure:
-
- Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
Post-translational modifications for HES4 Gene
Other Protein References for HES4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HES4 (HES-4)
- Novus Biologicals Antibodies for HES4
- Abcam antibodies for HES4
- Invitrogen Antibodies for HES4
- antibodies-online Antibodies for HES4: See all 36
- GeneTex HES4 antibody for HES4
-
Santa Cruz Biotechnology (SCBT) Antibodies for HES4
Protein Products
-
OriGene Purified Proteins for HES4
- Search Origene for MassSpec and Protein Over-expression Lysates for HES4
- Origene Custom Protein Services for HES4
- antibodies-online Proteins for HES4: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HES4
- Abcam proteins for HES4
Assay Products
No data available for DME Specific Peptides for HES4 Gene
Domains & Families for HES4 Gene
Gene Families for HES4 Gene
Protein Domains for HES4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HES4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9HCC6UniProtKB/Swiss-Prot:
HES4_HUMAN :- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- Domain:
-
- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
- Contains 1 bHLH (basic helix-loop-helix) domain.
- Contains 1 Orange domain.
Function for HES4 Gene
Molecular function for HES4 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for HES4 Gene
- GenomeRNAi human phenotypes for HES4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HES4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HES4 gene
- Search ViGene Biosciences for HES4
CRISPR Products
-
OriGene CRISPR knockouts for HES4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES4
- GenScript: Design CRISPR guide RNA sequences for HES4
miRNA for HES4 Gene
- miRTarBase miRNAs that target HES4
-
- hsa-mir-423-5p (MIRT038130)
- hsa-mir-149-5p (MIRT045541)
- hsa-mir-6720-5p (MIRT453146)
- hsa-mir-6512-3p (MIRT453147)
- hsa-mir-5581-5p (MIRT453148)
- hsa-mir-4297 (MIRT453149)
- hsa-mir-6880-3p (MIRT453150)
- hsa-mir-4699-5p (MIRT453151)
- hsa-mir-4530 (MIRT453152)
- hsa-mir-338-3p (MIRT453153)
- hsa-mir-3065-3p (MIRT453154)
- hsa-mir-181d-3p (MIRT453155)
- hsa-mir-4314 (MIRT486735)
miRNA Products
- Search ViGene Biosciences for HES4
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HES4
- Browse OriGene Inhibitory RNA Products For HES4
-
ViGene Biosciences ready-to-package AAV shRNAs for HES4 gene
Clone Products
- OriGene clones in human for HES4
- OriGene ORF clones in human for HES4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HES4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HES4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HES4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES4 Gene
Localization for HES4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HES4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
No data available for Gene Ontology (GO) - Cellular Components for HES4 Gene
Pathways & Interactions for HES4 Gene
More details on SuperPathways for HES4
No Data Available
Interacting Proteins for HES4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HES4 Gene
Transcripts for HES4 Gene
mRNA/cDNA for HES4 Gene
- (4) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HES4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HES4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES4
- GenScript: Design CRISPR guide RNA sequences for HES4
miRNA Products
- Search ViGene Biosciences for HES4
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HES4
- Browse OriGene Inhibitory RNA Products For HES4
-
ViGene Biosciences ready-to-package AAV shRNAs for HES4 gene
Clone Products
- OriGene clones in human for HES4
- OriGene ORF clones in human for HES4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | - | |||||||||||
| SP3: |
Expression for HES4 Gene
SOURCE GeneReport for Unigene cluster for HES4 Gene Hs.154029
Primer Products
-
OriGene qPCR primer pairs for HES4
-
OriGene qPCR primer pairs and template standards for HES4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HES4 Gene
Orthologs for HES4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HES4 36 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HES4 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HES4 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
ManyToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | -- 36 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | her6 36 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | dpn 36 |
|
ManyToMany | |
| h 36 |
|
ManyToMany | |||
| Side 36 |
|
ManyToMany |
- Species with no ortholog for HES4:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HES4 Gene
(4) SIMAP similar genes for HES4 Gene using alignment to 3 proteins:
Variants for HES4 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1936360 | -- | 1,000,731(-) | CCGCC(A/G)ACCTT | upstream-variant-2KB, utr-variant-5-prime | |
| rs2298214 | -- | 999,842(-) | GTGAG(G/T)GGGGC | intron-variant, reference, missense | |
| rs2488989 | -- | 998,741(-) | cgcat(C/T)cctgc | downstream-variant-500B | |
| rs2489000 | -- | 1,002,308(-) | AGGAG(A/G)CTCAC | upstream-variant-2KB | |
| rs2710867 | -- | 998,719(+) | GGGCG(C/G)GTGCG | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3e1 | CNV | Complex | 17122850 |
| essv4734 | CNV | CNV | 17122850 |
| nsv10161 | CNV | Gain+Loss | 18304495 |
| essv2408 | CNV | CNV | 17122850 |
| nsv517709 | CNV | Gain+Loss | 19592680 |
| nsv832980 | CNV | Gain | 17160897 |
| nsv428334 | CNV | Gain | 18775914 |
| dgv2n67 | CNV | Gain | 20364138 |
| nsv871883 | CNV | Gain+Loss | 21882294 |
| dgv9n71 | CNV | Loss | 21882294 |
| nsv871547 | CNV | Loss | 21882294 |
| dgv10n71 | CNV | Loss | 21882294 |
| dgv11n71 | CNV | Loss | 21882294 |
| dgv12n71 | CNV | Loss | 21882294 |
| dgv13n71 | CNV | Loss | 21882294 |
| nsv871483 | CNV | Loss | 21882294 |
| nsv827252 | CNV | Gain | 20364138 |
Gene Damage Index Score:
7.83;
83.50% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HES4 Gene
Disorders for HES4 Gene
Relevant External Links for HES4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HES4
No disorders were found for HES4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES4 Gene
Publications for HES4 Gene
- Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PMID: 11260262) Bessho Y. … Kageyama R. (Genes Cells 2001) 2 3 4 67
- Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3
- Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. (PMID: 25480889) Bai G. … Chen J.F. (Hum. Mol. Genet. 2015) 3
- Novel basic helix-loop-helix transcription factor hes4 antagonizes the function of twist-1 to regulate lineage commitment of bone marrow stromal/stem cells. (PMID: 25579220) Cakouros D. … Gronthos S. (Stem Cells Dev. 2015) 3
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
Products for HES4 Gene
- R&D Systems Antibodies for HES4 (HES-4)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HES4
- Search Origene for MassSpec and Protein Over-expression Lysates for HES4
- Origene Custom Protein Services for HES4
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HES4
- Browse OriGene Inhibitory RNA Products For HES4
- OriGene qPCR primer pairs for HES4
- OriGene qPCR primer pairs and template standards for HES4
- OriGene CRISPR knockouts for HES4
- OriGene clones in human for HES4
- OriGene ORF clones in human for HES4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for HES4
- GenScript Custom Assay Services for HES4
- GenScript Custom overexpressing Cell Line Services for HES4
- GenScript: Design CRISPR guide RNA sequences for HES4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HES4
- Novus Biologicals Antibodies for HES4
- Novus Biologicals proteins and lysates for HES4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HES4
- Abcam proteins for HES4
- Search for Assays for HES4 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for HES4: See all 36
- Search antibodies-online for kits
- antibodies-online Proteins for HES4: See all 3
- Search antibodies-online for peptides
- GeneTex HES4 antibody for HES4
- Search GeneTex for Proteins for HES4
- ViGene Biosciences adenoviral particle packaged cDNA for HES4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HES4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HES4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HES4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HES4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HES4 gene
- Search ViGene Biosciences for HES4
- Search ViGene Biosciences for HES4
- Santa Cruz Biotechnology (SCBT) Antibodies for HES4
- Search Santa Cruz Biotechnology (SCBT) for HES4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HES4
Sources for HES4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon