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Aliases for HES4 Gene

Aliases for HES4 Gene

  • Hes Family BHLH Transcription Factor 4 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 42 3 4
  • Hairy And Enhancer Of Split 4 3 4
  • BHLH Factor Hes4 3 4
  • BHLHb42 3 4
  • HHES4 3 4
  • Hairy And Enhancer Of Split 4 (Drosophila) 2
  • Transcription Factor HES-4 3

External Ids for HES4 Gene

Previous GeneCards Identifiers for HES4 Gene

  • GC01M000974
  • GC01M000924
  • GC01M000206

Summaries for HES4 Gene

GeneCards Summary for HES4 Gene

HES4 (Hes Family BHLH Transcription Factor 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and protein dimerization activity. An important paralog of this gene is HES1.

UniProtKB/Swiss-Prot for HES4 Gene

  • Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES4 Gene

Genomics for HES4 Gene

Regulatory Elements for HES4 Gene

Enhancers for HES4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G001066 2 FANTOM5 Ensembl ENCODE dbSUPER 7.5 -67.5 -67497 4.7 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D SSRP1 CCNL2 NOC2L ENSG00000230092 LOC100287934 ENSG00000237094 ATAD3A PUSL1 ENSG00000272512 CICP3 LINC01786
GH01G001061 1.7 Ensembl ENCODE dbSUPER 6.3 -62.3 -62346 4.1 MLX CREB3L1 AGO1 DMAP1 FEZF1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 CCNL2 ENSG00000240731 ENSG00000230092 LOC100288379 TMEM240 PUSL1 LINC01786 FAM87B LINC00115 NOC2L
GH01G000919 1.6 Ensembl ENCODE dbSUPER 5.6 +80.9 80895 2.4 PKNOX1 AGO1 ARID4B SIN3A FEZF1 ZNF2 KLF13 DEK ZNF263 ZHX2 ENSG00000230699 HES4 LINC00115 LOC100130417 GC01M000917
GH01G000975 1.3 Ensembl ENCODE 5.1 +23.7 23658 4.7 ATF1 PKNOX1 AGO1 SIN3A FEZF1 ZNF2 ZNF48 ZNF121 GLIS2 ELK1 PERM1 ENSG00000272512 ISG15 LINC01786 ENSG00000240731 HES4 CDK11A GC01M000971 PLEKHN1
GH01G000931 0.8 dbSUPER 6.8 +69.7 69691 0.9 NFIB KLF17 NFXL1 ZNF121 EGR2 ZNF263 ZEB2 TBX21 ZNF843 NFIC HES4 PERM1 GC01M000926 SAMD11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HES4 on UCSC Golden Path with GeneCards custom track

Promoters for HES4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000118 -315 801 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143
ENSR00000249807 1485 2401 MLX CREB3L1 DMAP1 FEZF1 ZNF263 SP3 NFYC MEF2D SSRP1 ZNF610

Genomic Location for HES4 Gene

998,962 bp from pter
1,001,285 bp from pter
2,324 bases
Minus strand

Genomic View for HES4 Gene

Genes around HES4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES4 Gene

Proteins for HES4 Gene

  • Protein details for HES4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor HES-4
    Protein Accession:
    Secondary Accessions:
    • Q5SVA5

    Protein attributes for HES4 Gene

    221 amino acids
    Molecular mass:
    23523 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

neXtProt entry for HES4 Gene

Post-translational modifications for HES4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HES4 Gene

No data available for DME Specific Peptides for HES4 Gene

Domains & Families for HES4 Gene

Gene Families for HES4 Gene

Protein Domains for HES4 Gene

Suggested Antigen Peptide Sequences for HES4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
genes like me logo Genes that share domains with HES4: view

Function for HES4 Gene

Molecular function for HES4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).

Gene Ontology (GO) - Molecular Function for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with HES4: view
genes like me logo Genes that share phenotypes with HES4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES4 Gene

Localization for HES4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HES4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HES4: view

Pathways & Interactions for HES4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HES4: view

No data available for Pathways by source and SIGNOR curated interactions for HES4 Gene

Drugs & Compounds for HES4 Gene

No Compound Related Data Available

Transcripts for HES4 Gene

Unigene Clusters for HES4 Gene

Hairy and enhancer of split 4 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -

Relevant External Links for HES4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HES4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HES4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HES4 Gene:


SOURCE GeneReport for Unigene cluster for HES4 Gene:


Evidence on tissue expression from TISSUES for HES4 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with HES4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES4 Gene

Orthologs for HES4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
-- 35
  • 100 (a)
(Canis familiaris)
Mammalia HES4 35
  • 83 (a)
(Bos Taurus)
Mammalia HES4 35
  • 77 (a)
(Monodelphis domestica)
Mammalia HES4 35
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 24 (a)
(Gallus gallus)
Aves -- 35
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
(Danio rerio)
Actinopterygii her6 35
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta h 35
  • 25 (a)
dpn 35
  • 22 (a)
Side 35
  • 16 (a)
Species where no ortholog for HES4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES4 Gene

Gene Tree for HES4 (if available)
Gene Tree for HES4 (if available)

Paralogs for HES4 Gene

Paralogs for HES4 Gene

(4) SIMAP similar genes for HES4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HES4: view

Variants for HES4 Gene

Sequence variations from dbSNP and Humsavar for HES4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000288620 -- 998,942(+) AAGAA(A/G)GAAAA downstream-variant-500B
rs1000627427 -- 999,719(+) ATGAG(A/G)GTTTT intron-variant, reference, synonymous-codon
rs1001256418 -- 1,000,738(+) GCGGC(C/G)GGGTC upstream-variant-2KB, utr-variant-5-prime
rs1001724786 -- 1,002,205(+) TTTGT(A/G)GAGAT upstream-variant-2KB
rs1003313473 -- 1,001,951(+) CCCCG(C/T)CCCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HES4 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
dgv5n100 CNV gain 25217958
esv2762302 CNV gain 21179565
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv428334 CNV gain 18775914
nsv482937 CNV loss 15286789
nsv517709 CNV gain+loss 19592680
nsv544895 CNV loss 21841781
nsv827252 CNV gain 20364138
nsv832980 CNV gain 17160897
nsv950451 CNV deletion 24416366

Variation tolerance for HES4 Gene

Gene Damage Index Score: 7.83; 83.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HES4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES4 Gene

Disorders for HES4 Gene

Relevant External Links for HES4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HES4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES4 Gene

Publications for HES4 Gene

  1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PMID: 11260262) Bessho Y. … Kageyama R. (Genes Cells 2001) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Novel basic helix-loop-helix transcription factor hes4 antagonizes the function of twist-1 to regulate lineage commitment of bone marrow stromal/stem cells. (PMID: 25579220) Cakouros D. … Gronthos S. (Stem Cells Dev. 2015) 3 64

Products for HES4 Gene

Sources for HES4 Gene

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