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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HES4 Gene

protein-coding GIFtS: 47
GCID: GC01M000924

Hairy And Enhancer Of Split 4 (Drosophila)

2 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Hairy And Enhancer Of Split 4 (Drosophila)¹ ²		hHES4² ³
Class B Basic Helix-Loop-Helix Protein 42² ³		Transcription Factor HES-4²
bHLHb42² ³		BHLHB42³
BHLH Factor Hes4² ³		Hairy And Enhancer Of Split 4³

External Ids:	HGNC: 24149¹	Entrez Gene: 57801²	Ensembl: ENSG00000188290⁷	OMIM: 608060⁵	UniProtKB: Q9HCC6³

Export aliases for HES4 gene to outside databases

Previous GC identifers: GC01M000974 GC01M000206

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HES4 Gene:

HES4 (hairy and enhancer of split 4 (Drosophila)) is a protein-coding gene. Diseases associated with HES4 include ascariasis, and trichuriasis. GO annotations related to this gene include protein dimerization activity and transcription factor binding. An important paralog of this gene is HES5.

UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6

Function: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_004350.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HES4 gene promoter:
CREB p53 deltaCREB MyoD
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for HES4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36

HES4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M000924: view genomic region (about GC identifiers)

Start:	934,342 bp from pter	End:	935,552 bp from pter
Size:	1,211 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6 (See protein sequence)

Recommended Name: Transcription factor HES-4

Size: 221 amino acids; 23523 Da

Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family

(By similarity)

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q5SVA5

Explore the universe of human proteins at neXtProt for HES4: NX_Q9HCC6

Explore proteomics data for HES4 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9HCC6

HES4 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001135939.1 NP_066993.1

ENSEMBL proteins:

ENSP00000393198 ENSP00000304595 ENSP00000425085

Human Recombinant Protein Products for HES4:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	Novus Biologicals HES4 Protein Novus Biologicals HES4 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for HES4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

HES4 for ontologies About GeneDecksing

HES4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for HES4 (HES-4)
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	Novus Biologicals HES4 Antibody
	Abcam antibodies for HES4
	Cloud-Clone Corp. Antibodies for HES4
	Search ThermoFisher Antibodies for HES4
	LSBio Antibodies in human, mouse, rat for HES4

Assay Products for HES4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for HES4
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HES4
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for HES4 Cloud-Clone Corp. CLIAs for HES4

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

bHLH: Basic helix-loop-helix proteins

3 InterPro protein domains:

IPR018352 Orange_subgr

IPR003650 Orange

IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q9HCC6

ProtoNet protein and cluster: Q9HCC6

2 Blocks protein domains:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB003650 Orange

UniProtKB/Swiss-Prot: HES4_HUMAN, Q9HCC6

Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box

(CACNAG), rather than the canonical E-box (CANNTG) (By similarity)

Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE

family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By

similarity)

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 Orange domain

HES4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HES4_HUMAN, Q9HCC6

Function: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008134	transcription factor binding	NAS	17611704
GO:0046983	protein dimerization activity	IEA	--

HES4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for HES4:

Decreased Hepatitis C virus re

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for HES4

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HES4

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HES4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HES4
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against HES4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HES4
			Sirion Biotech Customized adenovirus for overexpression of HES4 Customized adenovirus for potent knockdown of HES4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for HES4 (see all 12) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HES4 (NM_021170)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HES4
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HES4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/12 Interacting proteins for HES4 (Q9HCC6³ ENSP00000393198⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCBD1	P61457³, ENSP00000299299⁴	I2D: score=1 STRING: ENSP00000299299
PCBD2	Q9H0N5³, ENSP00000254908⁴	I2D: score=1 STRING: ENSP00000254908
ATP13A4	Q4VNC1³	I2D: score=1
CMSS1	Q9BQ75³	I2D: score=1
COPG2	Q9UBF2³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0030154	cell differentiation	IEA	--

HES4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HES4

Search CenterWatch for drugs/clinical trials and news about HES4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HES4 gene (2 alternative transcripts):

NM_001142467.1 NM_021170.3

Unigene Cluster for HES4:

Hairy and enhancer of split 4 (Drosophila)

Hs.154029 [show with all ESTs]

Unigene Representative Sequence: BM543941

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000428771(uc001aci.2 uc010nyc.1) ENST00000304952 ENST00000481869

ENST00000484667

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HES4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HES4
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for HES4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES4
		Sirion Biotech Custom design and validation of potent shRNA sequences against HES4

Clone Products:		OriGene clones in human, mouse for HES4 (see all 12) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HES4 (NM_021170)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4

Primer Products:		OriGene qPCR primer pairs and template standards for HES4 OriGene qSTAR qPCR primer pairs in human, mouse for HES4
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat HES4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES4

Additional mRNA sequence:

AB048791.1 BC012351.1

8 DOTS entries:

DT.75101873 DT.100860764 DT.92421458 DT.97795287 DT.100830033 DT.121366989 DT.100860763 DT.95374160

24/65 AceView cDNA sequences (see all 65):

BM747954 BU741558 BM127944 AW630809 BQ013563 BU622703 CB241590 BQ072399

BM727881 BM789724 BU634310 AW148795 BM128269 BF001578 BI602134 AW513999

BI763672 BM713553 BG325949 BI757407 AW161193 NM_021170 BX455241 BX281754

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for HES4 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b
SP1:					-
SP2:					-		-
SP3:

ECgene alternative splicing isoforms for HES4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HES4 expression in normal human tissues (normalized intensities) HES4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGAAGCGGC

About this image

HES4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/2 selected tissues (see all 2) fully expand


Endoderm (Gastrulation Derivatives)
Definitive endoderm-like cells (Generation of mesendoderm and definitive endoderm...

Brain (Nervous System)
N2/LSB induced-cells (Generation of midbrain dopaminergic, forebrain and hypothalamic...

See HES4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HES4

SOURCE GeneReport for Unigene cluster: Hs.154029

SABiosciences Custom PCR Arrays for HES4

Primer Products:		OriGene qPCR primer pairs and template standards for HES4 OriGene qSTAR qPCR primer pairs in human, mouse for HES4
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat HES4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HES4 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HES4⁶ HES1⁶	hairy and enhancer of split 1, (Drosophila)	46(a) 34(a)	1 ↔ 1 possible ortholog	21(2803581-2805434) 9(12410467-12423754)
lizard (Anolis carolinensis)	Reptilia	-- HES1⁶	Uncharacterized protein	47(a) 39(a)	possible ortholog possible ortholog	GL343334.1(1036941-1044433) GL343538.1(309240-313331)
zebrafish (Danio rerio)	Actinopterygii	her6⁶ her9⁶	hairy-related 9	47(a) 44(a)	possible ortholog possible ortholog	6(36329655-36332018) 23(23693662-23695447)
fruit fly (Drosophila melanogaster)	Insecta	h⁶ dpn⁶ (see all 3)	deadpan (see all 3)	22(a) 15(a) (see all 3)	many ↔ many many ↔ many (see all 3)	3L(8668859-8672353) 2R(4116476-4119832)

Species with no ortholog for HES4

ENSEMBL Gene Tree for HES4 (if available)
TreeFam Gene Tree for HES4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HES4 gene

HES5² HES6² HES2² HES1²

4 SIMAP similar genes for HES4 using alignment to 3 protein entries: HES4_HUMAN (see all proteins):

HES1 HEYL HES6 HES3

HES4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145897528^1,2	C	--	934144(+)	`GGAGC-/GGAGG GGAGG`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HES4 (934342 - 935552 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/17 variations for HES4 (see all 17): About this table

Variant ID	Type	Subtype	PubMed ID
dgv9n71	CNV	Loss	21882294
dgv12n71	CNV	Loss	21882294
dgv10n71	CNV	Loss	21882294
dgv13n71	CNV	Loss	21882294
dgv11n71	CNV	Loss	21882294
nsv871483	CNV	Loss	21882294
nsv871547	CNV	Loss	21882294
nsv428334	CNV	Gain	18775914
nsv832980	CNV	Gain	17160897
dgv2n67	CNV	Gain	20364138

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HES4

DNA2.0 Custom Variant and Variant Library Synthesis for HES4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HES4 for disorders           About GeneDecksing

OMIM gene information: 608060    OMIM disorders: --

2 diseases for HES4:    About MalaCards

ascariasis trichuriasis

Export disorders for HES4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HES4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HES4)

Utopia: connect your pdf to the dynamic
world of online information

Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PubMed id 11260262)^{1, 2, 3} Bessho Y.... Kageyama R. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PubMed id 15254753)^{1, 3} Katoh M. and Katoh M. (2004)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Effects of chronic ascariasis and trichuriasis on cyt okine production and gene expression in human blood: a cross-sectional study. (PubMed id 21666788)¹ Reina Ortiz M....Cooper P.J. (2011)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PubMed id 17611704)¹ Katoh M. and Katoh M. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57801	HGNC: 24149	AceView: Hes4	Ensembl:ENSG00000188290	euGenes: HUgn57801
ECgene: HES4	H-InvDB: HES4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HES4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HES4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HES4 gene:
Search GeneIP for patents involving HES4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
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	EMD Millipore Target Screening & Profiling Services

	Antibodies for HES4 (HES-4)		Browse Cell Culture Products
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	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
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	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for HES4
	OriGene qPCR primer pairs and template standards for HES4		OriGene Protein Over-expression Lysate for HES4
	OriGene Custom Mass Spec		OriGene clones in human, mouse for HES4
	OriGene qSTAR qPCR primer pairs in human, mouse for HES4		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HES4		OriGene Custom Protein Services for HES4

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HES4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HES4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES4

	GenScript Custom Purified and Recombinant Proteins Services for HES4		GenScript cDNA clones with any tag delivered in your preferred vector for HES4
	GenScript Custom Assay Services for HES4		GenScript Custom Superior Antibodies Services for HES4
	GenScript Custom overexpressing Cell Line Services for HES4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HES4 promoter
	Search Chromatin IP Primers for HES4
	Search RT² qPCR Primer Assays in human, mouse, rat HES4
	Search GNC Networks for HES4
	SABiosciences Custom PCR Arrays for HES4

Search Tocris compounds for HES4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
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	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HES4 antibodies
	HES4 proteins
	HES4 lysates

	Antibodies for HES4
	See all of Abcam's Antibodies, Kits and Proteins for HES4
	Custom Antibody / Protein Production Service
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	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for HES4
	Antibodies for HES4
	ELISAs for HES4
	CLIAs for HES4

Search LifeMap BioReagents cell lines for HES4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES4

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HES4
	Browse SwitchGear Promoter luciferase reporter plasmids for HES4

Search ThermoFisher Antibodies for HES4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES4

	inGenious Targeting Laboratory - Custom generated mouse model solutions for HES4
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HES4

Customized:

	stable knockdown cell line services for HES4
	inducible knockdown cell line services for HES4
	design and validation of potent shRNA sequences against HES4
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	stable overexpressing cell line services for HES4
	inducible overexpressing cell line services for HES4
	adenovirus for overexpression of HES4

LSBio Antibodies in human, mouse, rat for HES4

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HES4 gene at Home site.

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HES4 Gene

Hairy And Enhancer Of Split 4 (Drosophila)

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HES4 Gene

Hairy And Enhancer Of Split 4 (Drosophila)

Aliasesfor HES4 gene

Summariesfor HES4 gene

Genomic Viewsfor HES4 gene

Proteinsfor HES4 gene

Protein Domains /Familiesfor HES4 gene

Functionfor HES4 gene

Pathways & Interactionsfor HES4 gene

Drugs & Compoundsfor HES4 gene

Transcriptsfor HES4 gene

Expression for HES4 gene

Orthologsfor HES4 gene

Paralogsfor HES4 gene

Genomic Variantsfor HES4 gene

Disorders / Diseasesfor HES4 gene

Publicationsfor HES4 gene

External Searches for HES4 gene

Genome Databases showing HES4 gene

Other Databases showing HES4 gene

Specialized Databases showing HES4 gene

Intellectual Propertyfor HES4 gene

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Aliases
for HES4 gene

Summaries
for HES4 gene

Genomic Views
for HES4 gene

Proteins
for HES4 gene

Protein Domains /
Families
for HES4 gene

Function
for HES4 gene

Pathways & Interactions
for HES4 gene

Drugs & Compounds
for HES4 gene

Transcripts
for HES4 gene

Expression
for HES4 gene

Orthologs
for HES4 gene

Paralogs
for HES4 gene

Genomic Variants
for HES4 gene

Disorders / Diseases
for HES4 gene

Publications
for HES4 gene

Intellectual Property
for HES4 gene

Products
for HES4 gene