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Aliases for HES4 Gene

Aliases for HES4 Gene

  • Hes Family BHLH Transcription Factor 4 2 3
  • Class B Basic Helix-Loop-Helix Protein 42 3 4
  • Hairy And Enhancer Of Split 4 3 4
  • BHLH Factor Hes4 3 4
  • BHLHb42 3 4
  • HHES4 3 4
  • Hairy And Enhancer Of Split 4 (Drosophila) 2
  • Transcription Factor HES-4 3

External Ids for HES4 Gene

Summaries for HES4 Gene

GeneCards Summary for HES4 Gene

HES4 (Hes Family BHLH Transcription Factor 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and protein dimerization activity. An important paralog of this gene is HES5.

UniProtKB/Swiss-Prot for HES4 Gene

  • Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES4 Gene

Genomics for HES4 Gene

Genomic Location for HES4 Gene

998,962 bp from pter
1,001,224 bp from pter
2,263 bases
Minus strand

Genomic View for HES4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HES4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES4 Gene

Regulatory Elements for HES4 Gene

Proteins for HES4 Gene

  • Protein details for HES4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor HES-4
    Protein Accession:
    Secondary Accessions:
    • Q5SVA5

    Protein attributes for HES4 Gene

    221 amino acids
    Molecular mass:
    23523 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

neXtProt entry for HES4 Gene

Proteomics data for HES4 Gene at MOPED

Post-translational modifications for HES4 Gene

No Post-translational modifications

Other Protein References for HES4 Gene

No data available for DME Specific Peptides for HES4 Gene

Domains for HES4 Gene

Gene Families for HES4 Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for HES4 Gene

Suggested Antigen Peptide Sequences for HES4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).:
    • Q9HCC6
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.:
    • Q9HCC6
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q9HCC6
  • Contains 1 Orange domain.:
    • Q9HCC6
genes like me logo Genes that share domains with HES4: view

Function for HES4 Gene

Molecular function for HES4 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor. Binds DNA on N-box motifs: 5-CACNAG-3 (By similarity).

Gene Ontology (GO) - Molecular Function for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with HES4: view

Phenotypes for HES4 Gene

GenomeRNAi human phenotypes for HES4:
genes like me logo Genes that share phenotypes with HES4: view

miRNA for HES4 Gene

miRTarBase miRNAs that target HES4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HES4 Gene

Localization for HES4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES4 Gene

Subcellular locations from

Jensen Localization Image for HES4 Gene COMPARTMENTS Subcellular localization image for HES4 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HES4: view

Pathways for HES4 Gene

SuperPathways for HES4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HES4: view

No data available for Pathways by source for HES4 Gene

Transcripts for HES4 Gene

Unigene Clusters for HES4 Gene

Hairy and enhancer of split 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HES4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -

Relevant External Links for HES4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HES4 Gene

mRNA expression in normal human tissues for HES4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for HES4 Gene Hs.154029

genes like me logo Genes that share expressions with HES4: view

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for HES4 Gene

Orthologs for HES4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
-- 36
  • 100 (a)
(Bos Taurus)
Mammalia HES4 36
  • 77 (a)
(Canis familiaris)
Mammalia HES4 36
  • 83 (a)
(Monodelphis domestica)
Mammalia HES4 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
(Gallus gallus)
Aves -- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
(Danio rerio)
Actinopterygii her6 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta dpn 36
  • 22 (a)
h 36
  • 25 (a)
Side 36
  • 16 (a)
Species with no ortholog for HES4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES4 Gene

Gene Tree for HES4 (if available)
Gene Tree for HES4 (if available)

Paralogs for HES4 Gene

Paralogs for HES4 Gene

Selected SIMAP similar genes for HES4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HES4: view

Variants for HES4 Gene

Sequence variations from dbSNP and Humsavar for HES4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1936360 -- 1,000,731(-) CCGCC(A/G)ACCTT upstream-variant-2KB, utr-variant-5-prime
rs2298214 -- 999,842(-) GTGAG(G/T)GGGGC reference, missense, intron-variant
rs2488989 -- 998,741(-) cgcat(C/T)cctgc downstream-variant-500B
rs2489000 -- 1,002,308(-) AGGAG(A/G)CTCAC upstream-variant-2KB
rs2710867 -- 998,719(+) GGGCG(C/G)GTGCG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HES4 Gene

Variant ID Type Subtype PubMed ID
dgv3e1 CNV Complex 17122850
essv4734 CNV CNV 17122850
nsv10161 CNV Gain+Loss 18304495
essv2408 CNV CNV 17122850
nsv517709 CNV Gain+Loss 19592680
nsv832980 CNV Gain 17160897
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871883 CNV Gain+Loss 21882294
dgv9n71 CNV Loss 21882294
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv13n71 CNV Loss 21882294
nsv871483 CNV Loss 21882294
nsv827252 CNV Gain 20364138

Relevant External Links for HES4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES4 Gene

Disorders for HES4 Gene

No disorders were found for HES4 Gene.

No data available for UniProtKB/Swiss-Prot for HES4 Gene

Publications for HES4 Gene

  1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PMID: 11260262) Bessho Y. … Kageyama R. (Genes Cells 2001) 2 3 4
  2. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M. … Katoh M. (Int. J. Oncol. 2007) 3

Products for HES4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HES4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HES4
    • Block miRNA regulation of HES4 using miScript Target Protectors

    Sources for HES4 Gene

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