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Aliases for HES3 Gene

Aliases for HES3 Gene

  • Hes Family BHLH Transcription Factor 3 2 3
  • Class B Basic Helix-Loop-Helix Protein 43 3 4
  • Hairy And Enhancer Of Split 3 3 4
  • BHLHb43 3 4
  • Hairy And Enhancer Of Split 3 (Drosophila) 2
  • Transcription Factor HES-3 3

External Ids for HES3 Gene

Summaries for HES3 Gene

GeneCards Summary for HES3 Gene

HES3 (Hes Family BHLH Transcription Factor 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and protein dimerization activity.

UniProtKB/Swiss-Prot for HES3 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES3 Gene

Genomics for HES3 Gene

Genomic Location for HES3 Gene

6,244,192 bp from pter
6,245,578 bp from pter
1,387 bases
Plus strand

Genomic View for HES3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES3 Gene

Regulatory Elements for HES3 Gene

Proteins for HES3 Gene

  • Protein details for HES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor HES-3
    Protein Accession:
    Secondary Accessions:
    • Q5TGS0

    Protein attributes for HES3 Gene

    186 amino acids
    Molecular mass:
    19968 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
    • Sequence=CAI19439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for HES3 Gene

Proteomics data for HES3 Gene at MOPED

Post-translational modifications for HES3 Gene

No Post-translational modifications

Other Protein References for HES3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HES3 Gene

Domains for HES3 Gene

Gene Families for HES3 Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for HES3 Gene


  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG):
    • Q5TGS1
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.:
    • Q5TGS1
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q5TGS1
  • Contains 1 Orange domain.:
    • Q5TGS1
genes like me logo Genes that share domains with HES3: view

Function for HES3 Gene

Molecular function for HES3 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor of genes that require a bHLH protein for their transcription.

Gene Ontology (GO) - Molecular Function for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with HES3: view
genes like me logo Genes that share phenotypes with HES3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HES3 Gene

Localization for HES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES3 Gene

Subcellular locations from

Jensen Localization Image for HES3 Gene COMPARTMENTS Subcellular localization image for HES3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HES3: view

Pathways for HES3 Gene

SuperPathways for HES3 Gene

No Data Available

Interacting Proteins for HES3 Gene

Gene Ontology (GO) - Biological Process for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0021555 midbrain-hindbrain boundary morphogenesis IEA --
GO:0021557 oculomotor nerve development IEA --
genes like me logo Genes that share ontologies with HES3: view

No data available for Pathways by source for HES3 Gene

Transcripts for HES3 Gene

mRNA/cDNA for HES3 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HES3 Gene

Hairy and enhancer of split 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HES3 Gene

No ASD Table

Relevant External Links for HES3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HES3 Gene

mRNA expression in normal human tissues for HES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES3 Gene

This gene is overexpressed in Testis (27.1), Brain - Spinal cord (cervical c-1) (6.9), Brain - Amygdala (5.6), Brain - Substantia nigra (5.2), and Brain - Cerebellum (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HES3 Gene

SOURCE GeneReport for Unigene cluster for HES3 Gene Hs.532677

genes like me logo Genes that share expressions with HES3: view

Orthologs for HES3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HES3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HES3 36
  • 99.56 (n)
  • 99.33 (a)
HES3 37
  • 98 (a)
(Bos Taurus)
Mammalia HES3 36
  • 80.9 (n)
  • 76.4 (a)
HES3 37
  • 67 (a)
(Canis familiaris)
Mammalia HES3 36
  • 81.14 (n)
  • 76.57 (a)
HES3 37
  • 76 (a)
(Mus musculus)
Mammalia Hes3 36
  • 74.48 (n)
  • 68.57 (a)
Hes3 16
Hes3 37
  • 68 (a)
(Rattus norvegicus)
Mammalia Hes3 36
  • 74.1 (n)
  • 64.57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hes3 36
  • 66.28 (n)
  • 70.11 (a)
(Danio rerio)
Actinopterygii her3 37
  • 27 (a)
Species with no ortholog for HES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES3 Gene

Gene Tree for HES3 (if available)
Gene Tree for HES3 (if available)

Paralogs for HES3 Gene

Selected SIMAP similar genes for HES3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HES3: view

No data available for Paralogs for HES3 Gene

Variants for HES3 Gene

Sequence variations from dbSNP and Humsavar for HES3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4908870 -- 6,244,852(+) AGCAG(A/C/T)AAAGC intron-variant
rs6694955 -- 6,242,450(+) GCCCC(C/T)TTTGT upstream-variant-2KB
rs12239811 -- 6,243,564(+) TGGGA(C/T)ACAGG upstream-variant-2KB
rs12408527 -- 6,244,993(+) CTCCC(C/T)TCTCC intron-variant
rs61744283 -- 6,244,574(+) AAGGC(C/G)GACAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HES3 Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294
dgv8n67 CNV Gain 20364138
nsv508825 CNV Insertion 20534489
nsv871569 CNV Loss 21882294
dgv122n71 CNV Loss 21882294
dgv123n71 CNV Loss 21882294
nsv871385 CNV Loss 21882294
nsv871646 CNV Loss 21882294
dgv124n71 CNV Loss 21882294
nsv871266 CNV Loss 21882294

Relevant External Links for HES3 Gene

HapMap Linkage Disequilibrium report

Disorders for HES3 Gene

(1) University of Copenhagen DISEASES for HES3 Gene

genes like me logo Genes that share disorders with HES3: view

No data available for UniProtKB/Swiss-Prot for HES3 Gene

Publications for HES3 Gene

  1. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M. … Katoh M. (Int. J. Oncol. 2007) 3
  4. Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence. (PMID: 18162467) Fukami M. … Ogata T. (J. Biol. Chem. 2008) 3
  5. Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics. (PMID: 23393614) Park D.M. … Androutsellis-Theotokis A. (Sci Rep 2013) 3

Products for HES3 Gene

Sources for HES3 Gene

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