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Aliases for HES3 Gene

Aliases for HES3 Gene

  • Hes Family BHLH Transcription Factor 3 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 43 3 4
  • Hairy And Enhancer Of Split 3 3 4
  • BHLHb43 3 4
  • Hairy And Enhancer Of Split 3 (Drosophila) 2
  • Transcription Factor HES-3 3

External Ids for HES3 Gene

Previous GeneCards Identifiers for HES3 Gene

  • GC01P006237
  • GC01P006304
  • GC01P005452

Summaries for HES3 Gene

GeneCards Summary for HES3 Gene

HES3 (Hes Family BHLH Transcription Factor 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and protein dimerization activity.

UniProtKB/Swiss-Prot for HES3 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES3 Gene

Genomics for HES3 Gene

Regulatory Elements for HES3 Gene

Enhancers for HES3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F006598 1.6 FANTOM5 ENCODE 16.2 +358.1 358054 6.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 KLHL21 THAP3 RPL22 HES3 LOC102725193 ZBTB48 PHF13 PIR47122 PIR44711
GH01F006233 1.1 ENCODE 16.5 -9.2 -9168 3.4 ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 BRCA1 ZNF2 YY1 ICMT HES3 LINC00337 ZBTB48 GPR153 RNF207 RPL22
GH01F006204 1.1 ENCODE 16.4 -38.4 -38440 2.9 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 RNF207 HES3 LOC102724450
GH01F006412 1.3 Ensembl ENCODE 11.7 +170.8 170841 4.3 PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF48 ZNF121 ZNF143 ZNF207 KLF13 ESPN RNF207 ICMT LINC00337 HES3 PLEKHG5 LOC102724450 RPL22 CHD5 ACOT7
GH01F006218 0.9 ENCODE 12.2 -23.7 -23720 2.9 ELF3 ATF1 PKNOX1 ARID4B SIN3A RAD21 THRB ZNF48 ZNF121 RCOR1 ICMT HES3 CHD5 LINC00337 RPL22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HES3 on UCSC Golden Path with GeneCards custom track

Promoters for HES3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001741123 1542 1001 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF263 SP3 SP5

Genomic Location for HES3 Gene

Chromosome:
1
Start:
6,244,158 bp from pter
End:
6,245,578 bp from pter
Size:
1,421 bases
Orientation:
Plus strand

Genomic View for HES3 Gene

Genes around HES3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES3 Gene

Proteins for HES3 Gene

  • Protein details for HES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGS1-HES3_HUMAN
    Recommended name:
    Transcription factor HES-3
    Protein Accession:
    Q5TGS1
    Secondary Accessions:
    • Q5TGS0

    Protein attributes for HES3 Gene

    Size:
    186 amino acids
    Molecular mass:
    19968 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
    SequenceCaution:
    • Sequence=CAI19439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for HES3 Gene

Post-translational modifications for HES3 Gene

No Post-translational modifications

Other Protein References for HES3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HES3 Gene

Domains & Families for HES3 Gene

Gene Families for HES3 Gene

Protein Domains for HES3 Gene

Suggested Antigen Peptide Sequences for HES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TGS1

UniProtKB/Swiss-Prot:

HES3_HUMAN :
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
Domain:
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
genes like me logo Genes that share domains with HES3: view

Function for HES3 Gene

Molecular function for HES3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription.

Gene Ontology (GO) - Molecular Function for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with HES3: view
genes like me logo Genes that share phenotypes with HES3: view

Animal Models for HES3 Gene

MGI Knock Outs for HES3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HES3 Gene

Localization for HES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HES3 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HES3: view

Pathways & Interactions for HES3 Gene

No Data Available

Interacting Proteins for HES3 Gene

Gene Ontology (GO) - Biological Process for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0021555 midbrain-hindbrain boundary morphogenesis IEA --
genes like me logo Genes that share ontologies with HES3: view

No data available for Pathways by source and SIGNOR curated interactions for HES3 Gene

Transcripts for HES3 Gene

mRNA/cDNA for HES3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HES3 Gene

Hairy and enhancer of split 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES3 Gene

No ASD Table

Relevant External Links for HES3 Gene

GeneLoc Exon Structure for
HES3
ECgene alternative splicing isoforms for
HES3

Expression for HES3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES3 Gene

This gene is overexpressed in Testis (x27.1), Brain - Spinal cord (cervical c-1) (x6.9), Brain - Amygdala (x5.6), Brain - Substantia nigra (x5.2), and Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for HES3 Gene

This gene is overexpressed in Synovial fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HES3 Gene



Protein tissue co-expression partners for HES3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HES3 Gene:

HES3

SOURCE GeneReport for Unigene cluster for HES3 Gene:

Hs.532677
genes like me logo Genes that share expression patterns with HES3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HES3 Gene

Orthologs for HES3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HES3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HES3 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia HES3 34 35
  • 81.14 (n)
cow
(Bos Taurus)
Mammalia HES3 34 35
  • 80.9 (n)
mouse
(Mus musculus)
Mammalia Hes3 34 16 35
  • 74.48 (n)
rat
(Rattus norvegicus)
Mammalia Hes3 34
  • 74.1 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hes3 34
  • 66.28 (n)
zebrafish
(Danio rerio)
Actinopterygii her3 35
  • 27 (a)
OneToOne
Species where no ortholog for HES3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES3 Gene

ENSEMBL:
Gene Tree for HES3 (if available)
TreeFam:
Gene Tree for HES3 (if available)

Paralogs for HES3 Gene

(2) SIMAP similar genes for HES3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HES3: view

No data available for Paralogs for HES3 Gene

Variants for HES3 Gene

Sequence variations from dbSNP and Humsavar for HES3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111511669 -- 6,244,157(+) AAAGG(C/T)GGCGC upstream-variant-2KB
rs111849439 -- 6,244,520(+) GCCGG(C/T)CTAAT intron-variant
rs112857517 -- 6,243,976(+) GGGGA(-/G)GGGGG upstream-variant-2KB
rs113023476 -- 6,242,626(+) CCTCC(A/C)AGGCC upstream-variant-2KB
rs114198341 -- 6,244,394(+) CATCA(A/G)TGTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HES3 Gene

Variant ID Type Subtype PubMed ID
nsv831425 CNV loss 17160897
nsv545237 CNV loss 21841781
nsv545236 CNV loss 21841781
nsv508825 CNV insertion 20534489
dgv8n67 CNV gain 20364138

Variation tolerance for HES3 Gene

Gene Damage Index Score: 3.83; 58.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HES3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HES3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES3 Gene

Disorders for HES3 Gene

Relevant External Links for HES3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HES3

No disorders were found for HES3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES3 Gene

Publications for HES3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 3 4 64
  3. STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System? (PMID: 26783739) Nikolakopoulou P. … Androutsellis-Theotokis A. (Horm. Metab. Res. 2016) 3 64
  4. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. (PMID: 25371201) Masjkur J. … Androutsellis-Theotokis A. (J. Biol. Chem. 2014) 3 64
  5. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. (PMID: 24512568) Economopoulou M. … Androutsellis-Theotokis A. (Int. J. Radiat. Biol. 2014) 3 64

Products for HES3 Gene

Sources for HES3 Gene

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