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Aliases for HES3 Gene

Aliases for HES3 Gene

  • Hes Family BHLH Transcription Factor 3 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 43 3 4
  • Hairy And Enhancer Of Split 3 3 4
  • BHLHb43 3 4
  • Hairy And Enhancer Of Split 3 (Drosophila) 2

External Ids for HES3 Gene

Previous GeneCards Identifiers for HES3 Gene

  • GC01P006237
  • GC01P006304
  • GC01P005452

Summaries for HES3 Gene

GeneCards Summary for HES3 Gene

HES3 (Hes Family BHLH Transcription Factor 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and protein dimerization activity.

UniProtKB/Swiss-Prot for HES3 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES3 Gene

Genomics for HES3 Gene

Regulatory Elements for HES3 Gene

Enhancers for HES3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HES3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HES3 Gene

6,244,158 bp from pter
6,245,578 bp from pter
1,421 bases
Plus strand

Genomic View for HES3 Gene

Genes around HES3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES3 Gene

Proteins for HES3 Gene

  • Protein details for HES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor HES-3
    Protein Accession:
    Secondary Accessions:
    • Q5TGS0

    Protein attributes for HES3 Gene

    186 amino acids
    Molecular mass:
    19968 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
    • Sequence=CAI19439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for HES3 Gene

Proteomics data for HES3 Gene at MOPED

Post-translational modifications for HES3 Gene

No Post-translational modifications

Other Protein References for HES3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HES3 Gene

Domains & Families for HES3 Gene

Gene Families for HES3 Gene

Protein Domains for HES3 Gene

Suggested Antigen Peptide Sequences for HES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
genes like me logo Genes that share domains with HES3: view

Function for HES3 Gene

Molecular function for HES3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription.
genes like me logo Genes that share phenotypes with HES3: view

Animal Models for HES3 Gene

MGI Knock Outs for HES3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HES3 Gene

Localization for HES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES3 Gene

Subcellular locations from

Jensen Localization Image for HES3 Gene COMPARTMENTS Subcellular localization image for HES3 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for HES3 Gene

Pathways & Interactions for HES3 Gene

SuperPathways for HES3 Gene

No Data Available

Interacting Proteins for HES3 Gene

Gene Ontology (GO) - Biological Process for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0021555 midbrain-hindbrain boundary morphogenesis IEA --
GO:0021557 oculomotor nerve development IEA --
GO:0021575 hindbrain morphogenesis IEA --
GO:0021915 neural tube development IEA --
genes like me logo Genes that share ontologies with HES3: view

No data available for Pathways by source and SIGNOR curated interactions for HES3 Gene

Drugs & Compounds for HES3 Gene

No Compound Related Data Available

Transcripts for HES3 Gene

mRNA/cDNA for HES3 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HES3 Gene

Hairy and enhancer of split 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HES3 Gene

No ASD Table

Relevant External Links for HES3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HES3 Gene

mRNA expression in normal human tissues for HES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES3 Gene

This gene is overexpressed in Testis (x27.1), Brain - Spinal cord (cervical c-1) (x6.9), Brain - Amygdala (x5.6), Brain - Substantia nigra (x5.2), and Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for HES3 Gene

This gene is overexpressed in Synovial fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HES3 Gene

SOURCE GeneReport for Unigene cluster for HES3 Gene Hs.532677

genes like me logo Genes that share expression patterns with HES3: view

Protein tissue co-expression partners for HES3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HES3 Gene

Orthologs for HES3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HES3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HES3 35
  • 80.9 (n)
  • 76.4 (a)
HES3 36
  • 67 (a)
(Canis familiaris)
Mammalia HES3 35
  • 81.14 (n)
  • 76.57 (a)
HES3 36
  • 76 (a)
(Mus musculus)
Mammalia Hes3 35
  • 74.48 (n)
  • 68.57 (a)
Hes3 16
Hes3 36
  • 68 (a)
(Pan troglodytes)
Mammalia HES3 35
  • 99.56 (n)
  • 99.33 (a)
HES3 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Hes3 35
  • 74.1 (n)
  • 64.57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hes3 35
  • 66.28 (n)
  • 70.11 (a)
(Danio rerio)
Actinopterygii her3 36
  • 27 (a)
Species with no ortholog for HES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES3 Gene

Gene Tree for HES3 (if available)
Gene Tree for HES3 (if available)

Paralogs for HES3 Gene

(2) SIMAP similar genes for HES3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HES3: view

No data available for Paralogs for HES3 Gene

Variants for HES3 Gene

Sequence variations from dbSNP and Humsavar for HES3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4908870 -- 6,244,852(+) AGCAG(A/C/T)AAAGC intron-variant
rs6694955 -- 6,242,450(+) GCCCC(C/T)TTTGT upstream-variant-2KB
rs12408527 -- 6,244,993(+) CTCCC(C/T)TCTCC intron-variant
rs12239811 -- 6,243,564(+) TGGGA(C/T)ACAGG upstream-variant-2KB
rs72632572 -- 6,243,323(+) TGCTT(C/T)TCCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HES3 Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294
dgv8n67 CNV Gain 20364138
nsv508825 CNV Insertion 20534489
nsv871569 CNV Loss 21882294
dgv122n71 CNV Loss 21882294
dgv123n71 CNV Loss 21882294
nsv871385 CNV Loss 21882294
nsv871646 CNV Loss 21882294
dgv124n71 CNV Loss 21882294
nsv871266 CNV Loss 21882294

Variation tolerance for HES3 Gene

Gene Damage Index Score: 3.83; 58.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HES3 Gene

Disorders for HES3 Gene

Relevant External Links for HES3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HES3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES3 Gene

Publications for HES3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. (PMID: 24512568) Economopoulou M. … Androutsellis-Theotokis A. (Int. J. Radiat. Biol. 2014) 3
  3. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. (PMID: 25371201) Masjkur J. … Androutsellis-Theotokis A. (J. Biol. Chem. 2014) 3
  4. Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics. (PMID: 23393614) Park D.M. … Androutsellis-Theotokis A. (Sci Rep 2013) 3
  5. Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence. (PMID: 18162467) Fukami M. … Ogata T. (J. Biol. Chem. 2008) 3

Products for HES3 Gene

Sources for HES3 Gene