HES3 Gene
protein-coding GIFtS: 39
GCID: GC01P006304
|
|
hairy and enhancer of split 3 (Drosophila)
| |
Aliases
for HES3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hairy And Enhancer Of Split 3 (Drosophila)1 2 | | BHLHb431 | | Class B Basic Helix-Loop-Helix Protein 432 3 | | Transcription Factor HES-32 | | BHLHB433 | | Hairy And Enhancer Of Split 33 |
Export aliases for HES3 gene to outside databasesPrevious GC identifers: GC01P006237 GC01P005452 |
Summaries
for HES3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HES3_HUMAN, Q5TGS1Function: Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity)
|
Genomic Views
for HES3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HES3 gene promoter:
Max1 NRSF form 1 ARP-1 STAT3 NRSF form 2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for HES3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.31 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.31HES3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P006304: view genomic region
(about GC identifiers)
Start:
|
6,304,252 bp from pter |
End:
|
6,305,638 bp from pter |
Size:
|
1,387 bases |
Orientation:
|
plus strand |
|
Proteins
for HES3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HES3_HUMAN, Q5TGS1 (See
protein sequence)Recommended Name: Transcription factor HES-3 Size: 186 amino acids; 19968 Da
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family(By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=CAI19439.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TGS0Explore the universe of human proteins at neXtProt for HES3: NX_Q5TGS1
HES3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001019769.1
ENSEMBL proteins: ENSP00000367130
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
HES3 for ontologies About GeneDecksing
HES3 Antibody Products:
Assay Products for HES3: |
Protein
Domains /
Families
for HES3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HES3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5TGS1ProtoNet protein and cluster: Q5TGS1 1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH
UniProtKB/Swiss-Prot: HES3_HUMAN, Q5TGS1Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box(CACNAG), rather than the canonical E-box (CANNTG)Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLEfamily members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (Bysimilarity)Similarity: Contains 1 bHLH (basic helix-loop-helix) domainSimilarity: Contains 1 Orange domain |
Function
for HES3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HES3_HUMAN, Q5TGS1Function: Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HES3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HES3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HES3 (NM_001024598) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HES3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
HES3 for ontologies About GeneDecksing
Animal Models:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hes3):
HES3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HES3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HES3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/10 Interacting proteins for HES3 (ENSP000003671304) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0001701 | in utero embryonic development |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0021555 | midbrain-hindbrain boundary morphogenesis |
IEA | -- | | GO:0021557 | oculomotor nerve development |
IEA | -- |
HES3 for ontologies About GeneDecksing
|
Drugs & Compounds
for HES3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HES3
Search CenterWatch for drugs/clinical trials and news about HES3
|
Transcripts
for HES3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HES3 gene: NM_001024598.3 Unigene Cluster for HES3: Hairy and enhancer of split 3 (Drosophila) Hs.532677 [show with all ESTs]Unigene Representative Sequence: CX7623071 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000377898(uc009vly.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HES3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HES3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HES3 (NM_001024598) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HES3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES3 |
1 DOTS entry: DT.102837123
GeneLoc Exon Structure
|
Expression
for HES3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HES3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACAGCGCCG
About this image
See HES3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.532677
SABiosciences Custom PCR Arrays for HES3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HES3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HES3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES3 |
Orthologs
for HES3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for HES3 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Hes31 , 5 |
hairy and enhancer of split 3 (Drosophila)1, 5 |
74.48(n)1
68.57(a)1 |
|
4 (83.01 cM)5
152071 NM_008237.41 NP_032263.21
1522859725 |
ENSEMBL Gene Tree for HES3 (if available)
TreeFam Gene Tree for HES3 (if available) |
Paralogs
for HES3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HES3 gene
- HEYL2 HES42 HES62 HELT2 HEY22 HES72 HEY12 HES52
- HES22 HES12
2 SIMAP similar genes for HES3 using alignment to 1 protein entry: HES3_HUMAN:HES1 HES4
HES3 for paralogs About GeneDecksing
|
Genomic Variants
for HES3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HES3 (6304252 - 6305638 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HES3
1 CNV: 4200 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HES3 |
|
Disorders
/ Diseases
for HES3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HES3 for disorders About GeneDecksing
OMIM gene information: 609971
OMIM disorders: --
2  diseases for HES3: About MalaCardshypospadias neuronitis
1 disease from the University of Copenhagen DISEASES database for HES3:Hypospadias Export disorders for HES3 gene to outside databases
|
Publications
for HES3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HES3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HES3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PubMed id 15254753)1, 2 Katoh M. and Katoh M. (2004)
- Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence. (PubMed id 18162467)1 Fukami M.... Ogata T. (2008)
- Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PubMed id 17611704)1 Katoh M. and Katoh M. (2007)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for HES3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HES3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HES3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HES3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HES3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HES3 gene:
Search GeneIP for patents involving HES3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HES3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HES3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HES3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HES3 | | | OriGene Protein Over-expression Lysate for HES3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HES3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HES3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HES3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HES3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HES3 | | OriGene Custom Protein Services for HES3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HES3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HES3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HES3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HES3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HES3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HES3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for HES3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | HES3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for HES3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES3 |
|
|
|
|
