Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HES2 Gene

protein-coding   GIFtS: 50
GCID: GC01M006472

Hes Family BHLH Transcription Factor 2

(Previous name: hairy and enhancer of split 2 (Drosophila))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hes Family BHLH Transcription Factor 21 2     Hairy And Enhancer Of Split 2 (Drosophila)1
Class B Basic Helix-Loop-Helix Protein 402 3     Transcription Factor HES-22
Hairy And Enhancer Of Split 22 3     BHLHB403
bHLHb402 3     

External Ids:    HGNC: 160051   Entrez Gene: 546262   Ensembl: ENSG000000698127   OMIM: 6099705   UniProtKB: Q9Y5433   

Export aliases for HES2 gene to outside databases

Previous GC identifers: GC01M006049 GC01M006281 GC01U900784 GC01M006183 GC01M006406 GC01M005622


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for HES2 Gene:
HES2 (hes family bHLH transcription factor 2) is a protein-coding gene. GO annotations related to this gene include double-stranded DNA binding and transcription factor binding. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot: HES2_HUMAN, Q9Y543
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the HES2 gene promoter:
         AhR   LCR-F1   Arnt   E47   N-Myc   Max   AREB6   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHES2 promoter sequence
   Search Chromatin IP Primers for HES2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HES2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.31   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36.31

HES2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HES2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006472:  view genomic region     (about GC identifiers)

Start:
6,472,478 bp from pter      End:
6,484,730 bp from pter
Size:
12,253 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HES2_HUMAN, Q9Y543 (See protein sequence)
Recommended Name: Transcription factor HES-2  
Size: 173 amino acids; 18470 Da
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE
family (By similarity)
Secondary accessions: A2RTZ9 Q96EN4 Q9Y542
Alternative splicing: 2 isoforms:  Q9Y543-1   Q9Y543-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HES2: NX_Q9Y543

Explore proteomics data for HES2 at MOPED


See HES2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_061962.2  
ENSEMBL proteins: 
 ENSP00000367068   ENSP00000367067   ENSP00000367065   ENSP00000465248   ENSP00000465270  

HES2 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for HES2
OriGene Protein Over-expression Lysate for HES2
OriGene MassSpec for HES2
OriGene Custom Protein Services for HES2
GenScript Custom Purified and Recombinant Proteins Services for HES2
Novus Biologicals HES2 Proteins
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for HES2
Cloud-Clone Corp. Proteins for HES2

 
Search eBioscience for Proteins for HES2 

 
antibodies-online proteins for HES2 (4 products) 

 
Search antibodies-online for peptides for HES2

HES2 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for HES2
Novus Biologicals HES2 Antibodies
Abcam antibodies for HES2
Cloud-Clone Corp. Antibodies for HES2
ThermoFisher Antibodies for HES2
antibodies-online antibodies for HES2 (27 products) 

HES2 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for HES2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HES2
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HES2
Cloud-Clone Corp. CLIAs for HES2
Search eBioscience for ELISAs for HES2 
antibodies-online kits for HES2 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
bHLH: Basic helix-loop-helix proteins

3 InterPro protein domains:
 IPR018352 Orange_subgr
 IPR003650 Orange
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q9Y543

ProtoNet protein and cluster: Q9Y543

2 Blocks protein domains:
IPB001092 Basic helix-loop-helix dimerization domain bHLH
IPB003650 Orange


UniProtKB/Swiss-Prot: HES2_HUMAN, Q9Y543
Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box
(CACNAG), rather than the canonical E-box (CANNTG)
Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with
Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related
proteins (By similarity)
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
Similarity: Contains 1 Orange domain


Find genes that share domains with HES2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HES2_HUMAN, Q9Y543
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity)

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003690double-stranded DNA binding IEA--
GO:0008134transcription factor binding NAS17611704
GO:0046983protein dimerization activity IEA--
     
Find genes that share ontologies with HES2           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for HES2:
 Decreased nuclei size in G2M  Increased G2M DNA content 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for HES2

miRNA
Products:
    
miRTarBase miRNAs that target HES2:
hsa-mir-335-5p (MIRT018989)

Block miRNA regulation of human, mouse, rat HES2 using miScript Target Protectors
6 qRT-PCR Assays for microRNAs that regulate HES2:
hsa-miR-3650 hsa-miR-513b hsa-miR-2115 hsa-miR-622 hsa-miR-548q hsa-miR-335
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HES2
Predesigned siRNA for gene silencing in human, mouse, rat HES2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HES2

Clone
Products:
     
OriGene clones in human, mouse for HES2 (see all 5)
OriGene ORF clones in mouse, rat for HES2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HES2 (NM_019089)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES2

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for HES2
Browse ESI BIO Cell Lines and PureStem Progenitors for HES2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
HES2_HUMAN, Q9Y543: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with HES2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HES2
Interactions:

    Search GeneGlobe Interaction Network for HES2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for HES2 (ENSP000003670654) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
ARTNENSP000003919984STRING: ENSP00000391998
ENSG00000225073ENSP000004003264STRING: ENSP00000400326
ENSG00000228605ENSP000004012724STRING: ENSP00000401272
IPO13ENSP000003614184STRING: ENSP00000361418
PRPF38BENSP000003590424STRING: ENSP00000359042
About this table

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0045892negative regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with HES2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HES2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for HES2 gene: 
NM_019089.4  

Unigene Cluster for HES2:

Hairy and enhancer of split 2 (Drosophila)
Hs.118727  [show with all ESTs]
Unigene Representative Sequence: NM_019089
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377837(uc001amw.3) ENST00000377836 ENST00000471190 ENST00000377834(uc001amx.3)
ENST00000487437 ENST00000489730
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HES2 using miScript Target Protectors
6 qRT-PCR Assays for microRNAs that regulate HES2:
hsa-miR-3650 hsa-miR-513b hsa-miR-2115 hsa-miR-622 hsa-miR-548q hsa-miR-335
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HES2
Predesigned siRNA for gene silencing in human, mouse, rat HES2
Clone
Products:
     
OriGene clones in human, mouse for HES2 (see all 5)
OriGene ORF clones in mouse, rat for HES2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HES2 (NM_019089)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HES2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for HES2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HES2
  QuantiTect SYBR Green Assays in human, mouse, rat HES2
  QuantiFast Probe-based Assays in human, mouse, rat HES2

Additional mRNA sequence: 

AK023754.1 AK091122.1 BC012091.1 BC132698.1 BC136963.1 BC142687.1 

4 DOTS entries:

DT.410244  DT.70100638  DT.100745863  DT.100829461 

Selected AceView cDNA sequences (see all 52):

BM998306 AK091122 AW516444 AA339789 AA127465 BC012091 AA702466 C00167 
AA515208 BU729177 BX108718 AI275093 BG470458 CB961786 AI738963 BI223008 
AU140197 AL602811 AA878200 CB128893 AI760454 BF354381 BE904050 AI333927 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for HES2 (see all 6)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1:        -     -                                                         
SP2:        -     -                 -     -     -     -     -               
SP3:                                                                        
SP4:                                                                        
SP5:                                -                                       


ECgene alternative splicing isoforms for HES2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

HES2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCGTGGGAA
HES2 Expression
About this image


HES2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Eye (Sensory Organs)
         Retina
 
 Placenta (Extraembryonic Tissues)
HES2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HES2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.118727

UniProtKB/Swiss-Prot: HES2_HUMAN, Q9Y543
Tissue specificity: Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head
and neck tumors

    Custom PCR Arrays for HES2
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for HES2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HES2
QuantiTect SYBR Green Assays in human, mouse, rat HES2
QuantiFast Probe-based Assays in human, mouse, rat HES2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for HES2 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hes21 , 5 hairy and enhancer of split 2 (Drosophila)1, 5 81.33(n)1
77.6(a)1
  4 (82.92 cM)5
152061  NM_008236.41  NP_032262.21 
 1521588675 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
21(a)
many ↔ many
21(1426230-1429603)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
35(a)
many ↔ many
3(28102928-28104037)
tropical clawed frog
(Xenopus tropicalis)
Amphibia hes21 hes family bHLH transcription factor 2 60.47(n)
62.83(a)
  100038090  XM_002933843.2  XP_002933889.1 
zebrafish
(Danio rerio)
Actinopterygii hes2.11 hairy and enhancer of split 2, tandem duplicate 1 58.1(n)
59.63(a)
  559147  NM_001123245.1  NP_001116717.1 
fruit fly
(Drosophila melanogaster)
Insecta h6
Side6
(see all 3)
similar to Deadpan
(see all 3)
18(a)
13(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
3L(8668859-8672353)
2L(19027712-19030787)


ENSEMBL Gene Tree for HES2 (if available)
TreeFam Gene Tree for HES2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for HES2 gene
HES42  HES52  HES62  HES12  
3 SIMAP similar genes for HES2 using alignment to 3 protein entries:     HES2_HUMAN (see all proteins):
HES1    HES6    HES5

Find genes that share paralogs with HES2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for HES2 (see all 129)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs38384821,2
C--6474812(-) tgcgt-/AGGTGTG
CATGTGCGT
gtgtt
1 -- int10--------
rs613008061,2
C,F--6474879(+) ACTCGA/GAGGAG 1 -- int11Minor allele frequency- G:0.03WA 118
rs580252581,2
C,F--6474883(+) GAAGGA/CGGCTC 1 -- int11Minor allele frequency- C:0.02WA 118
rs1915828181,2
--6475121(+) AAAATA/GAAAAA 1 -- int10--------
rs1497915631,2
--6475161(+) AGTCCC/TAGCTA 1 -- int10--------
rs1837950841,2
--6475230(+) CATTAC/TTGCAC 1 -- int10--------
rs1883488431,2
--6475261(+) AAGACC/TCTGTC 1 -- int10--------
rs1933014181,2
--6475323(+) GTCAAG/TATATT 1 -- ut310--------
rs803513891,2
--6475344(+) TTTTTA/TAAACA 1 -- ut310--------
rs1113204711,2
C--6475344(+) TTTTT-/A/TT  
        
AAACA
2 -- ut311CSA 2

HapMap Linkage Disequilibrium report for HES2 (6472478 - 6484730 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for HES2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv508836CNV Insertion20534489
dgv125n71CNV Loss21882294
nsv871698CNV Loss21882294
nsv871719CNV Loss21882294
dgv2n27CNV Loss19166990
dgv122n71CNV Loss21882294
nsv871453CNV Loss21882294
dgv119n71CNV Loss21882294
esv25412CNV Gain+Loss19812545
nsv7880CNV Gain+Loss18304495

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HES2
DNA2.0 Custom Variant and Variant Library Synthesis for HES2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 609970    OMIM disorders: --


Find genes that share disorders with HES2           About GenesLikeMe


Export disorders for HES2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for HES2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with HES2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PubMed id 15254753)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PubMed id 17611704)1, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2007)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. (PubMed id 9570950)1 Nishimura M....Kageyama R. (Genomics 1998)
  8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 54626 HGNC: 16005 AceView: HES2 Ensembl:ENSG00000069812 euGenes: HUgn54626
ECgene: HES2 H-InvDB: HES2

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for HES2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HES2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for HES2 gene:
Search GeneIP for patents involving HES2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HES2  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HES2  
 OriGene MassSpec for HES2   OriGene clones in human, mouse for HES2  
 OriGene qSTAR qPCR primer pairs in human, mouse for HES2   OriGene Purified Protein for HES2  
 OriGene ORF clones in mouse, rat for HES2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for HES2   OriGene Custom Protein Services for HES2  

 
 
 Block miRNA regulation of human, mouse, rat HES2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HES2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HES2 Predesigned siRNA for gene silencing in human, mouse, rat HES2
 QuantiFast Probe-based Assays in human, mouse, rat HES2 QuantiTect SYBR Green Assays in human, mouse, rat HES2
 Custom PCR Arrays for HES2 Search Chromatin IP Primers for HES2
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HES2  Search GeneGlobe Interaction Network for HES2
 Regulatory tfbs in HES2 promoter
 GenScript Custom Purified and Recombinant Proteins Services for HES2 GenScript cDNA clones with any tag delivered in your preferred vector for HES2
 GenScript Custom Assay Services for HES2 GenScript Custom overexpressing Cell Line Services for HES2
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for HES2
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 HES2 antibodies
 HES2 proteins
 Antibodies for HES2
 See all of Abcam's Antibodies, Kits and Proteins for HES2
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for HES2
 Proteins for HES2
 Antibodies for HES2
 ELISAs for HES2
 CLIAs for HES2



 Browse ESI BIO Cell Lines and PureStem Progenitors for HES2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HES2
 Browse SwitchGear 3'UTR luciferase reporter plasmids for HES2
 SwitchGear Promoter luciferase reporter plasmids for HES2
 ThermoFisher Antibodies for HES2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HES2
 Browse compounds at ApexBio
 Search Addgene for plasmids for HES2
  Search eBioscience for proteins for HES2
  Search eBioscience for elisas for HES2
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for HES2
 antibodies-online antibodies for HES2 (27 products)
 antibodies-online kits for HES2 (6 products)
  Search antibodies-online for peptides for HES2
 antibodies-online proteins for HES2 (4 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      HES2 gene at Home site.
Version: 3.12.250 16 Nov 2014
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4