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Aliases for HES2 Gene

Aliases for HES2 Gene

  • Hes Family BHLH Transcription Factor 2 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 40 3 4
  • Hairy And Enhancer Of Split 2 3 4
  • BHLHb40 3 4
  • Hairy And Enhancer Of Split 2 (Drosophila) 2
  • Transcription Factor HES-2 3

External Ids for HES2 Gene

Previous GeneCards Identifiers for HES2 Gene

  • GC01M006049
  • GC01M006281
  • GC01U900784
  • GC01M006183
  • GC01M006406
  • GC01M005622

Summaries for HES2 Gene

GeneCards Summary for HES2 Gene

HES2 (Hes Family BHLH Transcription Factor 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and double-stranded DNA binding. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot for HES2 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES2 Gene

Genomics for HES2 Gene

Regulatory Elements for HES2 Gene

Enhancers for HES2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F006299 0.8 FANTOM5 ENCODE 2.1 +123.2 123234 4.5 HDGF ATF1 PKNOX1 CREB3L1 ARID4B DMAP1 ZNF2 YY1 GLIS2 GATA2 ESPN ACOT7 ZBTB48 PLEKHG5 GPR153 HES2 THAP3 NPHP4 GC01P006262 ENSG00000271746
GH01F006422 0.7 Ensembl ENCODE 0.8 +0.4 356 3.2 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 ZNF263 SP3 MIER2 TSHZ1 REST ESPN LOC102724450 RNF207 RPL22 ACOT7 HES2 GC01M006398
GH01F006412 0.9 Ensembl ENCODE 0.4 +9.7 9672 4.3 PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF48 ZNF121 ZNF143 ZNF207 KLF13 ESPN RNF207 ICMT LINC00337 HES3 PLEKHG5 LOC102724450 RPL22 CHD5 ACOT7
GH01F006418 0.9 ENCODE 0.4 +5.9 5901 0.3 ZNF121 BCOR RPL22 LOC102724450 RNF207 HES2 GC01M006398
GH01F006404 0.4 ENCODE 0.3 +19.8 19835 0.2 ZFP64 ZNF493 ARID4B FEZF1 ZNF121 GLIS2 ZNF302 ZNF143 KLF7 ZNF548 RPL22 PHF13 ZBTB48 GC01M006398 HES2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HES2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HES2 Gene

Chromosome:
1
Start:
6,412,418 bp from pter
End:
6,424,670 bp from pter
Size:
12,253 bases
Orientation:
Minus strand

Genomic View for HES2 Gene

Genes around HES2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES2 Gene

Proteins for HES2 Gene

  • Protein details for HES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y543-HES2_HUMAN
    Recommended name:
    Transcription factor HES-2
    Protein Accession:
    Q9Y543
    Secondary Accessions:
    • A2RTZ9
    • Q96EN4
    • Q9Y542

    Protein attributes for HES2 Gene

    Size:
    173 amino acids
    Molecular mass:
    18470 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

    Alternative splice isoforms for HES2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HES2 Gene

Post-translational modifications for HES2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HES2 Gene

No data available for DME Specific Peptides for HES2 Gene

Domains & Families for HES2 Gene

Gene Families for HES2 Gene

Protein Domains for HES2 Gene

Suggested Antigen Peptide Sequences for HES2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y543

UniProtKB/Swiss-Prot:

HES2_HUMAN :
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
Domain:
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
genes like me logo Genes that share domains with HES2: view

Function for HES2 Gene

Molecular function for HES2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription.

Gene Ontology (GO) - Molecular Function for HES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with HES2: view
genes like me logo Genes that share phenotypes with HES2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES2 Gene

Localization for HES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HES2 Gene COMPARTMENTS Subcellular localization image for HES2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HES2: view

Pathways & Interactions for HES2 Gene

SuperPathways for HES2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HES2: view

No data available for Pathways by source and SIGNOR curated interactions for HES2 Gene

Transcripts for HES2 Gene

Unigene Clusters for HES2 Gene

Hairy and enhancer of split 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - -
SP2: - - - - - - -
SP3:
SP4:
SP5: -
SP6: - - - - -

Relevant External Links for HES2 Gene

GeneLoc Exon Structure for
HES2
ECgene alternative splicing isoforms for
HES2

Expression for HES2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HES2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES2 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.1), Vagina (x8.2), Skin - Not Sun Exposed (Suprapubic) (x7.5), Skin - Sun Exposed (Lower leg) (x6.8), and Cervix - Ectocervix (x4.4).

Protein differential expression in normal tissues from HIPED for HES2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HES2 Gene



Protein tissue co-expression partners for HES2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HES2 Gene:

HES2

SOURCE GeneReport for Unigene cluster for HES2 Gene:

Hs.118727

mRNA Expression by UniProt/SwissProt for HES2 Gene:

Q9Y543-HES2_HUMAN
Tissue specificity: Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
genes like me logo Genes that share expression patterns with HES2: view

Primer Products

Orthologs for HES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HES2 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia HES2 34 35
  • 82.22 (n)
rat
(Rattus norvegicus)
Mammalia Hes2 34
  • 81.36 (n)
mouse
(Mus musculus)
Mammalia Hes2 34 16 35
  • 81.33 (n)
dog
(Canis familiaris)
Mammalia HES2 34 35
  • 80.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HES2 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HES2 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hes2 34
  • 60.47 (n)
zebrafish
(Danio rerio)
Actinopterygii hes2.1 34 35
  • 58.1 (n)
hes2.2 35
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta h 35
  • 18 (a)
ManyToMany
dpn 35
  • 13 (a)
ManyToMany
Side 35
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToOne
Species where no ortholog for HES2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES2 Gene

ENSEMBL:
Gene Tree for HES2 (if available)
TreeFam:
Gene Tree for HES2 (if available)

Paralogs for HES2 Gene

Paralogs for HES2 Gene

(3) SIMAP similar genes for HES2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HES2: view

Variants for HES2 Gene

Sequence variations from dbSNP and Humsavar for HES2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1054273 -- 6,415,527(-) CAGAC(G/T)ACTCC utr-variant-3-prime
rs1054274 -- 6,415,526(-) AGACG(A/C)CTCCT utr-variant-3-prime
rs111320471 -- 6,415,285(+) TTTTT(-/A/TT)AAACA utr-variant-3-prime
rs111576917 -- 6,418,649(+) CCAGC(A/C)AAGTT utr-variant-3-prime
rs111617671 -- 6,416,130(+) CTGGG(A/G)CAATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HES2 Gene

Variant ID Type Subtype PubMed ID
dgv2n27 CNV loss 19166990
dgv80n54 CNV loss 21841781
esv25412 CNV gain+loss 19812545
nsv1009548 CNV loss 25217958
nsv508836 CNV insertion 20534489
nsv545240 CNV loss 21841781
nsv7880 CNV gain+loss 18304495
nsv954048 CNV deletion 24416366

Variation tolerance for HES2 Gene

Gene Damage Index Score: 3.36; 53.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HES2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HES2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES2 Gene

Disorders for HES2 Gene

Relevant External Links for HES2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HES2

No disorders were found for HES2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES2 Gene

Publications for HES2 Gene

  1. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 4 22 64
  2. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M. … Katoh M. (Int. J. Oncol. 2007) 3 22 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HES2 Gene

Sources for HES2 Gene

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