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Aliases for HES2 Gene

Aliases for HES2 Gene

  • Hes Family BHLH Transcription Factor 2 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 40 3 4
  • Hairy And Enhancer Of Split 2 3 4
  • BHLHb40 3 4
  • Hairy And Enhancer Of Split 2 (Drosophila) 2

External Ids for HES2 Gene

Previous GeneCards Identifiers for HES2 Gene

  • GC01M006049
  • GC01M006281
  • GC01U900784
  • GC01M006183
  • GC01M006406
  • GC01M005622

Summaries for HES2 Gene

GeneCards Summary for HES2 Gene

HES2 (Hes Family BHLH Transcription Factor 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and double-stranded DNA binding. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot for HES2 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES2 Gene

Genomics for HES2 Gene

Regulatory Elements for HES2 Gene

Enhancers for HES2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HES2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HES2 Gene

6,412,418 bp from pter
6,424,670 bp from pter
12,253 bases
Minus strand

Genomic View for HES2 Gene

Genes around HES2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES2 Gene

Proteins for HES2 Gene

  • Protein details for HES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor HES-2
    Protein Accession:
    Secondary Accessions:
    • A2RTZ9
    • Q96EN4
    • Q9Y542

    Protein attributes for HES2 Gene

    173 amino acids
    Molecular mass:
    18470 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

    Alternative splice isoforms for HES2 Gene


neXtProt entry for HES2 Gene

Proteomics data for HES2 Gene at MOPED

Post-translational modifications for HES2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HES2 Gene

No data available for DME Specific Peptides for HES2 Gene

Domains & Families for HES2 Gene

Gene Families for HES2 Gene

Protein Domains for HES2 Gene

Suggested Antigen Peptide Sequences for HES2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
genes like me logo Genes that share domains with HES2: view

Function for HES2 Gene

Molecular function for HES2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription.

Gene Ontology (GO) - Molecular Function for HES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with HES2: view
genes like me logo Genes that share phenotypes with HES2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES2 Gene

Localization for HES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES2 Gene

Subcellular locations from

Jensen Localization Image for HES2 Gene COMPARTMENTS Subcellular localization image for HES2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HES2 Gene

Pathways & Interactions for HES2 Gene

SuperPathways for HES2 Gene

No Data Available

Interacting Proteins for HES2 Gene

Gene Ontology (GO) - Biological Process for HES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HES2: view

No data available for Pathways by source and SIGNOR curated interactions for HES2 Gene

Drugs & Compounds for HES2 Gene

No Compound Related Data Available

Transcripts for HES2 Gene

Unigene Clusters for HES2 Gene

Hairy and enhancer of split 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HES2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - -
SP2: - - - - - - -
SP5: -
SP6: - - - - -

Relevant External Links for HES2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HES2 Gene

mRNA expression in normal human tissues for HES2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES2 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.1), Vagina (x8.2), Skin - Not Sun Exposed (Suprapubic) (x7.5), Skin - Sun Exposed (Lower leg) (x6.8), and Cervix - Ectocervix (x4.4).

Protein differential expression in normal tissues from HIPED for HES2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HES2 Gene

SOURCE GeneReport for Unigene cluster for HES2 Gene Hs.118727

mRNA Expression by UniProt/SwissProt for HES2 Gene

Tissue specificity: Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
genes like me logo Genes that share expression patterns with HES2: view

Protein tissue co-expression partners for HES2 Gene

- Elite partner

Primer Products

Orthologs for HES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HES2 35
  • 82.22 (n)
  • 83.03 (a)
HES2 36
  • 85 (a)
(Canis familiaris)
Mammalia HES2 35
  • 80.81 (n)
  • 72.12 (a)
HES2 36
  • 71 (a)
(Mus musculus)
Mammalia Hes2 35
  • 81.33 (n)
  • 77.6 (a)
Hes2 16
Hes2 36
  • 73 (a)
(Pan troglodytes)
Mammalia HES2 35
  • 100 (n)
  • 100 (a)
HES2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Hes2 35
  • 81.36 (n)
  • 78.74 (a)
(Monodelphis domestica)
Mammalia HES2 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia HES2 36
  • 62 (a)
(Gallus gallus)
Aves -- 36
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hes2 35
  • 60.47 (n)
  • 62.83 (a)
(Danio rerio)
Actinopterygii hes2.1 35
  • 58.1 (n)
  • 59.63 (a)
hes2.1 36
  • 38 (a)
hes2.2 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta dpn 36
  • 13 (a)
h 36
  • 18 (a)
Side 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
Species with no ortholog for HES2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES2 Gene

Gene Tree for HES2 (if available)
Gene Tree for HES2 (if available)

Paralogs for HES2 Gene

Paralogs for HES2 Gene

(3) SIMAP similar genes for HES2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HES2: view

Variants for HES2 Gene

Sequence variations from dbSNP and Humsavar for HES2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2235687 - 6,418,980(-) GTGGC(C/T)CGTCT reference, missense
rs11364 -- 6,415,626(-) AGGTC(A/G)AATCT utr-variant-3-prime
rs15552 -- 6,415,352(+) CGAGC(A/G)TGTGC utr-variant-3-prime
rs1054273 -- 6,415,527(-) CAGAC(A/C/G/T)ACTCC utr-variant-3-prime
rs1054274 -- 6,415,526(-) AGACG(A/C)CTCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HES2 Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
dgv122n71 CNV Loss 21882294
dgv125n71 CNV Loss 21882294
dgv2n27 CNV Loss 19166990
nsv508836 CNV Insertion 20534489
esv25412 CNV Gain+Loss 19812545
nsv871453 CNV Loss 21882294
nsv871719 CNV Loss 21882294
nsv7880 CNV Gain+Loss 18304495

Variation tolerance for HES2 Gene

Gene Damage Index Score: 3.36; 53.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HES2 Gene

Disorders for HES2 Gene

Relevant External Links for HES2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HES2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES2 Gene

Publications for HES2 Gene

  1. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 4 23 67
  2. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M. … Katoh M. (Int. J. Oncol. 2007) 3 23
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for HES2 Gene

Sources for HES2 Gene