Aliases for HES1 Gene
Aliases for HES1 Gene
External Ids for HES1 Gene
- HGNC: 5192
- Entrez Gene: 3280
- Ensembl: ENSG00000114315
- OMIM: 139605
- UniProtKB: Q14469
Previous HGNC Symbols for HES1 Gene
- HRY
Previous GeneCards Identifiers for HES1 Gene
- GC03P195130
- GC03P195255
- GC03P195174
- GC03P195336
- GC03P193853
- GC03P191241
Summaries for HES1 Gene
-
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
GeneCards Summary for HES1 Gene
HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with HES1 include Maturity-Onset Diabetes Of The Young and Chromosome 3Q29 Deletion Syndrome. Among its related pathways are Signaling by NOTCH1 and C-MYB transcription factor network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HES4.
UniProtKB/Swiss-Prot for HES1 Gene
-
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5-CACNAG-3 with high affinity and on E-box motifs: 5-CANNTG-3 with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES1 Gene
Genomics for HES1 Gene
Regulatory Elements for HES1 Gene
Enhancers for HES1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HES1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HES1 gene promoter:
Regulatory Element Products
Genomic Location for HES1 Gene
- Chromosome:
- 3
- Start:
- 194,136,142 bp from pter
- End:
- 194,138,732 bp from pter
- Size:
- 2,591 bases
- Orientation:
- Plus strand
Genomic View for HES1 Gene
Genes around HES1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q29 by Ensembl
- 3q29 by Entrez Gene
- 3q29 by HGNC
HES1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HES1 Gene
Proteins for HES1 Gene
-
Protein details for HES1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14469-HES1_HUMAN
- Recommended name:
- Transcription factor HES-1
- Protein Accession:
- Q14469
- Q6FHB2
Protein attributes for HES1 Gene
- Size:
- 280 amino acids
- Molecular mass:
- 29541 Da
- Quaternary structure:
-
- Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE.
Protein Expression for HES1 Gene
Post-translational modifications for HES1 Gene
Other Protein References for HES1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HES1 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HES1
- R&D Systems Antibodies for HES1 (HES-1)
- Cell Signaling Technology (CST) Antibodies for HES1 (HES1)
-
Custom Antibody ServicesOriGene Antibodies for HES1
- AM10222PU-N
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- AP31766PU-N
- TA336954
- TA504001S
- TA500114S
- TA500114JM
- TA500114HM
- TA500114GM
- TA500114FM
- TA500114EM
- TA500114CM
- TA700484
- TA700483
- TA700482
- TA600485
- TA600484
- TA600483
- TA600482
- CF504088
- TA504088
- CF504067
- TA504067
- CF504046
- TA504046
- CF504045
- TA504045
- CF504002
- TA504002
- CF504001
- TA504001
- CF503958
- TA503958
- CF500114
- TA500114
- TA351243
- Novus Biologicals Antibodies for HES1
-
Cloud-Clone Corp. Antibodies for HES1
- Invitrogen Antibodies for HES1
- GeneTex HES1 antibody for HES1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HES1
Protein Products
-
OriGene Purified Proteins for HES1
- Search Origene for MassSpec and Protein Over-expression Lysates for HES1
- Origene Custom Protein Services for HES1
-
Cloud-Clone Corp. Proteins for HES1
- Search GeneTex for Proteins for HES1
-
ProSci Proteins for HES1
Assay Products
No data available for DME Specific Peptides for HES1 Gene
Domains & Families for HES1 Gene
Gene Families for HES1 Gene
Protein Domains for HES1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HES1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14469UniProtKB/Swiss-Prot:
HES1_HUMAN :- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- Domain:
-
- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
- The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.
Function for HES1 Gene
Molecular function for HES1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5-CACNAG-3 with high affinity and on E-box motifs: 5-CANNTG-3 with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ISS,IEA | -- |
| GO:0003677 | DNA binding | TAS | 7906273 |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IDA | 17681138 |
| GO:0005515 | protein binding | IPI | 12535671 |
Phenotypes for HES1 Gene
- MGI mutant phenotypes for HES1:
-
inferred from 7 alleles
- mortality/aging
- cellular phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for HES1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HES1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
- Search ViGene Biosciences for HES1
CRISPR Products
-
OriGene CRISPR knockouts for HES1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES1
- GenScript: Design CRISPR guide RNA sequences for HES1
miRNA for HES1 Gene
- miRTarBase miRNAs that target HES1
miRNA Products
- Search ViGene Biosciences for HES1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HES1
- Browse OriGene Inhibitory RNA Products For HES1
-
ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
Clone Products
- Sino Biological Human cDNA Clone for HES1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HES1
Cell Line Products
-
Horizon Cell Lines for HES1
-
ViGene Biosciences adenoviral particle packaged cDNA for HES1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HES1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HES1 Gene
Localization for HES1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HES1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for HES1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Notch signaling pathway (KEGG) | ||
| 3 | Regulation of beta-cell development | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
Pathways by source for HES1 Gene
1 Cell Signaling Technology pathway for HES1 Gene
11 BioSystems pathways for HES1 Gene
4 KEGG pathways for HES1 Gene
1 GeneGo (Thomson Reuters) pathway for HES1 Gene
2 R&D Systems pathways for HES1 Gene
Interacting Proteins for HES1 Gene
Selected Interacting proteins:
ENSP00000232424
Q14469-HES1_HUMAN
for HES1 Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for HES1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 12032823 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001889 | liver development | IEA | -- |
| GO:0003143 | embryonic heart tube morphogenesis | ISS,IEA | -- |
| GO:0003151 | outflow tract morphogenesis | IEA,ISS | -- |
Transcripts for HES1 Gene
mRNA/cDNA for HES1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (213) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HES1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HES1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES1
- GenScript: Design CRISPR guide RNA sequences for HES1
miRNA Products
- Search ViGene Biosciences for HES1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HES1
- Browse OriGene Inhibitory RNA Products For HES1
-
ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
Clone Products
- Sino Biological Human cDNA Clone for HES1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HES1
Flow Cytometry Products
Expression for HES1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Acinar Progenitor Cells Dorsal Pancreatic Bud
- Fetal Matrix Cells Hair Follicle
- Anterior Lens Epithelial Cells Lens
- Fetal Inner Root Sheath Cells Inner Root Sheath
-
Pancreas (Endocrine System)
- Acinar Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Duct Progenitor Cells Dorsal Pancreatic Bud
- Centroacinar Cells Pancreatic Ducts
- Duct Progenitor Cells Ventral Pancreatic Bud
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Fetal Matrix Cells Hair Follicle
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Fetal Hair Shaft Cuticle Cells Hair Shaft
- Fetal Medulla Cells Hair Shaft
-
Eye (Sensory Organs)
- Anterior Lens Epithelial Cells Lens
- Equatorial Lens Epithelial Cells Lens
- Late Retinal Progenitor Cells Retinal Neuroblastic Layer
- Muller Glia Precursor Cells Inner Nuclear Layer
- Early Retinal Progenitor Cells Retinal Neuroblastic Layer
- Neural Tube (Nervous System)
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Paraxial Mesoderm Cells Paraxial Mesoderm
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Paraxial Mesoderm Cells Paraxial Mesoderm
-
Tooth (Integumentary System)
- Primary Enamel Knot Cells Enamel Knot
- Stellate Reticulum Cells Dental Core
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Cerebellum
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Liver (Hepatobiliary System)
- Periportal Hepatocytes Liver Lobule
-
Ectoderm (Gastrulation Derivatives)
- Preplacodal Ectoderm Cells Preplacodal Ectoderm
-
Lung (Respiratory System)
- Bronchiolar Progenitor Cells Stem Bronchi
-
Somite (Muscoskeletal System)
- Presomitic Mesoderm Cells Presomitic Mesoderm
-
Epidermis (Integumentary System)
- Granular Keratinocytes Stratified Epidermis
- Gut Tube (Gastrointestinal Tract)
- Blood (Hematopoietic System)
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HES1 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.4).
This gene is overexpressed in Blymphocyte (52.9) and Heart (16.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HES1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HES1 Gene:
HES1SOURCE GeneReport for Unigene cluster for HES1 Gene:
Hs.250666Evidence on tissue expression from TISSUES for HES1 Gene
- Liver(4.9)
- Kidney(4.4)
- Nervous system(2.5)
- Eye(2.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for HES1
-
OriGene qPCR primer pairs and template standards for HES1
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES1 Gene
Orthologs for HES1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HES1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HES1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hes1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hes1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HES1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HES1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHAIRY-1 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hes1 34 |
|
||
| Str.10866 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397813 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | her6 34 |
|
||
| her9 35 |
|
ManyToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.686 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | h 35 |
|
ManyToMany | |
| dpn 35 |
|
ManyToMany | |||
| Side 35 |
|
ManyToMany |
- Species where no ortholog for HES1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HES1 Gene
Variants for HES1 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001457073 | -- | 194,135,022(+) | TCCCT(C/G)CCCCC | upstream-variant-2KB | |
| rs1001888324 | -- | 194,134,901(+) | CCAGG(C/T)GCAGG | upstream-variant-2KB | |
| rs1002143313 | -- | 194,138,897(+) | TTGTT(C/T)TTCTA | downstream-variant-500B | |
| rs1002257985 | -- | 194,139,102(+) | TTCAA(A/G)TAAGA | downstream-variant-500B | |
| rs1002483272 | -- | 194,134,283(+) | GCACC(-/CGGCGG)CGGCG | upstream-variant-2KB |
Residual Variation Intolerance Score:
19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.48;
10.47% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HES1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HES1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES1 Gene
Disorders for HES1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| maturity-onset diabetes of the young |
|
|
| chromosome 3q29 deletion syndrome |
|
|
| chromosome 3q29 microdeletion syndrome |
|
|
Search HES1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HES1
No data available for UniProtKB/Swiss-Prot and Genatlas for HES1 Gene
Publications for HES1 Gene
- HES1 is a novel interactor of the Fanconi anemia core complex. (PMID: 18550849) Tremblay C.S. … Carreau M. (Blood 2008) 3 4 22 64
- Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. (PMID: 8020957) Feder J.N. … Jan Y.-N. (Genomics 1994) 2 3 4 64
- SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells. (PMID: 19322650) MA1ller P. … StrAPm A. (Breast Cancer Res. Treat. 2010) 3 22 64
- Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura. (PMID: 19603167) Ma D. … Hou M. (Ann. Hematol. 2010) 3 22 64
- Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. (PMID: 19861684) Nakahara F. … Chiba S. (Blood 2010) 3 22 64
Products for HES1 Gene
- R&D Systems Antibodies for HES1 (HES-1)
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- Custom Antibody ServicesOriGene Antibodies for HES1
- AM10222PU-N
- AP13263PU-N
- AP31766PU-N
- TA336954
- TA351243
- TA500114
- CF500114
- TA503958
- CF503958
- TA504001
- CF504001
- TA504002
- CF504002
- TA504045
- CF504045
- TA504046
- CF504046
- TA504067
- CF504067
- TA504088
- CF504088
- TA600482
- TA600483
- TA600484
- TA600485
- TA700482
- TA700483
- TA700484
- TA500114CM
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- TA500114GM
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- TA500114S
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- OriGene qPCR primer pairs and template standards for HES1
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- GenScript: Design CRISPR guide RNA sequences for HES1
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- Cell Signaling Technology (CST) Antibodies for HES1 (HES1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for HES1
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HES1
- Novus Biologicals proteins and lysates for HES1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for HES1
- Cloud-Clone Corp. Proteins for HES1
- Browse Assay Kits at Cloud-Clone Corp.
- ViGene Biosciences adenoviral particle packaged cDNA for HES1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HES1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HES1 gene
- Search ViGene Biosciences for HES1
- Santa Cruz Biotechnology (SCBT) Antibodies for HES1
- Search Santa Cruz Biotechnology (SCBT) for HES1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HES1
- Horizon Cell Lines for HES1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HES1
- VectorBuilder custom plasmid, inducible vectors for HES1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HES1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HES1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer