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HES1 Gene

protein-coding GIFtS: 59

GC03P195336

hairy and enhancer of split 1, (Drosophila)
(Previous name: hairy homolog (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HRY)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ20408 ^¹, ²
HES-1 ^¹, ²
HHL ^², ³
HL ^³
HRY ^², ³, ⁵
Hairy-like ^³
Hes1 ^¹
bHLHb39 ^¹, ²

Descriptions
Hairy and enhancer of split 1 ^², ³
Hairy homolog ^², ³
hairy and enhancer of split 1, (Drosophila) ^²
hairy homolog (Drosophila) ^¹
transcription factor HES-1 ^²

External Ids
HGNC: 5192¹
Entrez Gene: 3280²
UniProtKB: Q14469³
Ensembl: ENSG00000114315⁷

Search outside databases for aliases for HES1 gene

Previous GC identifers: GC03P195130 GC03P195255 GC03P195174

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HES1:

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a

transcriptional repressor of genes that require a bHLH protein for their transcription. The

protein has a particular type of basic domain that contains a helix interrupting protein that

binds to the N-box rather than the canonical E-box. [provided by RefSeq]

UniProtKB/Swiss-Prot: HES1_HUMAN, Q14469

Function: Transcriptional repressor of genes that require a bHLH protein for their transcription.

May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds

DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low

affinity (By similarity)

Gene Wiki entry for HES1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HES1 gene

Entrez Gene cytogenetic band: 3q28-q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q28-q29

HES1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P195336: (about GC identifiers)

Start:	195,336,628 bp from pter
End:	195,339,090 bp from pter
Size:	2,463 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HES1_HUMAN, Q14469 (See protein sequence)

Recommended Name: Transcription factor HES-1

Size: 280 amino acids; 29541 Da

Subunit: Transcription repression requires formation of a complex with a corepressor protein of the

Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts

with HES6 (By similarity). Interacts with SIRT1

Subcellular location: Nucleus

Secondary accessions: Q6FHB2

REFSEQ proteins: NP_005515.1

ENSEMBL proteins:

ENSP00000232424

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hes1)
	Human Recombinant Proteins from Abnova (HES1)

OriGene Purified Recombinant Human Protein: HES1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for HES1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HES1
	Sigma-Aldrich Antibodies for HES1
	R&D Systems Antibodies for HES1 (HES-1)
	Antibodies from Abcam (Hes1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HES1)
	Novus Biologicals Antibodies for HES1

Assays for HES1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14469

ProtoNet protein and cluster: Q14469

2 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB003650 Orange

UniProtKB/Swiss-Prot: HES1_HUMAN, Q14469

Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds

to the N-box (CACNAG), rather than the canonical E-box (CANNTG)

Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the

interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific

target DNA by Hairy-related proteins (By similarity)

Domain: The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW

motif, is required for transcriptional repressor activity (By similarity)

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 Orange domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HES1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HES1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005524

Applied Biosystems Silencer® siRNAs for HES1

Sigma-Aldrich siRNA for HES1

Sigma-Aldrich shRNA Panels and shRNA for HES1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HES1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005524
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005524
untagged cDNA clone in CMV expression vector: NM_005524

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005524

UniProtKB/Swiss-Prot: HES1_HUMAN, Q14469

Function: Transcriptional repressor of genes that require a bHLH protein for their transcription.

May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds

DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low

affinity (By similarity)

13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hes1):

craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size
hearing/vestibular/ear	lethality-prenatal/perinatal	liver/biliary system	nervous system	respiratory system
skeleton	taste/olfaction	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	7906273
GO:0016564	transcription repressor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for HES1 (Your Favorite Gene powered by Ingenuity)

Notch Signaling
VDR/RXR Activation

GeneDecks HES1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HES1

3 Interacting proteins for HES1 (ENSP00000232424³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TLE1	ENSP00000347102³	STRING (score=.837)
NEUROG3	ENSP00000242462³	STRING (score=.8)
SIRT1	ENSP00000212015³	STRING (score=.795)

About this table

5/22 Gene Ontology (GO) biological process terms (links to tree view) (see all 22 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001701	in utero embryonic development	IEA	--
GO:0001889	liver development	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007155	cell adhesion	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HES1
4 Novoseek chemical compound relationships for HES1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tetrapeptide	22.55	2	10617648 (1), 12972610 (1)
12-o-tetradecanoylphorbol 13-acetate	7.23	2	15743775 (1)
oligonucleotide	0.00	2	11054669 (1)
glycogen	0.00	1	17234779 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HES1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HES1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005524

Sigma-Aldrich siRNA for HES1

Sigma-Aldrich shRNA Panels and shRNA for HES1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005524

REFSEQ mRNAs for HES1 gene:

NM_005524.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005524

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005524
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005524
                                 untagged cDNA clone in CMV expression vector: NM_005524

Additional cDNA sequence:

AF264785.1 AK000415.1 AK300482.1 BC005178.1 BC039152.1 CR541843.1 CR609648.1 CR610974.1

CR616000.1

8 DOTS entries:

DT.455057 DT.97848019 DT.120913653 DT.100787901 DT.100787905 DT.95072022 DT.95285462 DT.100787904

24/213 AceView cDNA sequences (see all 213 ):

BF063295 AA428311 F29544 CB158770 NM_005524 H85827 CA443860 AW511570

BM091066 BU753172 AW189760 AW469992 BM820077 AW026193 BE857348 BM713155

BM718748 BM840285 BU753369 W19562 BM761683 BM760757 AI337008 AI431412

highest scoring ESTs for HES1:

AA083206 AA083303 AA236810 AA305552 AA430428 AA588621 AA904840 AA907024 AA910411 AA913699

Unigene Cluster for HES1:

Hairy and enhancer of split 1, (Drosophila)

Hs.250666 [show with all ESTs]

Unigene Representative Sequence: NM_005524

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000232424

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HES1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HES1

¹ / ² / ³

5 probe-sets matching HES1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37393_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L19314	0.20	1.00	0.72	1
203395_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005524	0.60	1.00	0.82	1
203394_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE973687	0.40	1.00	0.76	1
203395_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203394_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACTATATTT

SOURCE GeneReport for Unigene cluster: Hs.250666
Expression variation in blood from EXPOLDB for HES1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HES1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	HES1¹	--	hairy and enhancer of split 1, (Drosophila)	99.88(n) 100(a)	460942 XM_516956.2 XP_516956.1
cow (Bos taurus)	HES1¹	--	hairy and enhancer of split 1, (Drosophila)	93.81(n) 99.64(a)	539547 NM_001034678.1 NP_001029850.1
rat (Rattus norvegicus)	Hes1¹	--	hairy and enhancer of split 1 (Drosophila)	92.62(n) 98.21(a)	29577 NM_024360.2 NP_077336.2
mouse (Mus musculus)	Hes1^{1, 5}	16 (27.00 cM)⁵	hairy and enhancer of split 1 (Drosophila)^{1, 5}	92.02(n)¹ 98.21(a)¹	15205¹ NM_008235.2¹ NP_032261.1¹ AK132536⁵ AK133538⁵ (see all 8)
chicken (Gallus gallus)	HES1¹	--	hairy and enhancer of split 1, (Drosophila)	65.9(n) 71.65(a)	395128 NM_001005848.1 NP_001005848.1

About this table Species with no ortholog for HES1

ENSEMBL Gene Tree for HES1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HES1 gene

HES4² HES6² HES2² HES3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/23 NCBI SNPs in HES1 are shown (see all 23 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs16825120^1,2	F	195336230(+)	`AAAAAA/-TATGT`	1	--	ng5¹		2		MN EA	356
	rs2368048^1,2	A,C,F,H	195337655(+)	`ACTCTC/TGCGTT`	1	--	int¹		12		EU EA WA NA	1186
	rs2236747^1,2	C,F,H	195337351(+)	`GAGATA/CATGCT`	1	--	int¹		11		EU EA WA NA	1108
--	rs4396832^1,2	--	195335152(+)	`GGGAGC/GCGGGG`	1	--	ng5¹		0	--	--	--	--
--	rs34266498^1,2	--	195338463(+)	`CCCCC-/CTCCCG`	1	P/P	fra¹		0	--	--	--	--
--	rs4488782^1,2	--	195335162(+)	`GGTTGA/GAAAAA`	1	--	ng5¹		0	--	--	--	--
	rs11541816^1,2	--	195337176(+)	`GATTTG/TGGATG`	1	L/W	mis¹		0	--	--	--	--
	rs55782996^1,2	--	195336502(+)	`TCCACA/GAGCGG`	1	--	ng5¹		0	--	--	--	--
	rs4607050^1,2	--	195335134(+)	`AGCCCG/TAAAGT`	1	--	ng5¹		0	--	--	--	--
--	rs11541817^1,2	--	195338897(-)	`AGTGCA/GTGGTC`	1	--	ut3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for HES1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 139605

10/15 Novoseek disease relationships for HES1 gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
t-all	67.25	3	17549349 (2)
medulloblastoma	26.92	1	15520184 (1)
leukemia	23.70	1	15866157 (1)
tumors	19.90	12	18491256 (4), 19020755 (3), 18719287 (1), 11127827 (1) (see all 5)
carcinoid	16.99	6	16360401 (6)
colon cancer	6.62	1	11127827 (1)
colorectal cancer	3.38	4	19020755 (1), 17611704 (1)
cancer lung	0.00	6	9144241 (2), 17804716 (1)
melanoma	0.00	4	16916793 (2), 16715130 (1)
pancreatic cancer	0.00	3	17611704 (1)

About this table

Human Genome Epidemiology Navigator: HES1 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/164 PubMed articles for HES1 gene (see all 164 ):

Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. (PubMed id 8020957)^{2, 3, 4} Feder J.N.... Jan Y.-N. (1994)
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. (PubMed id 12535671)^{1, 3, 4} Takata T. and Ishikawa F. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
HES-1, a novel target gene for the aryl hydrocarbon receptor. (PubMed id 14722248)^{1, 3} Thomsen J.S....Gustafsson J.A. (2004)
Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. (PubMed id 12972610)^{1, 3} Gratton M.O....Stifani S. (2003)
Lack of nuclear expression of hairy and enhancer of split-1 (HES1) in pancreatic endocrine tumors. (PubMed id 18491256)^{1, 3} Johansson T....Skogseid B. (2008)
The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. (PubMed id 10851137)^{1, 3} Bae S.-K.... Kageyama R. (2000)
Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation. (PubMed id 9389649)^{1, 3} Strom A....Caudy M. (1997)
HES1 is a novel interactor of the Fanconi anemia core complex. (PubMed id 18550849)^{1, 3} Tremblay C.S....Carreau M. (2008)
Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. (PubMed id 11756408)^{1, 3} Jogi A....Axelson H. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3280	HGNC: 5192	AceView: HES1	Ensembl:ENSG00000114315	euGenes: HUgn3280
ECgene: HES1	H-InvDB: HES1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HES1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HES1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HES1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HES1		Antibodies for HES1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HES1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HES1)
	Antibodies (HES1)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Hes1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for HES1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HES1

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HES1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for HES1

Summaries
for HES1

Genomic Location
for HES1

Proteins
for HES1

Protein Domains/
Families
for HES1

Gene Function
for HES1

Pathways & Interactions
for HES1

Drugs & Compounds
for HES1

Transcripts
for HES1

Expression
for HES1

Orthologs
for HES1

Paralogs
for HES1

SNPs/Variants
for HES1

Disorders & Mutations
for HES1

Medical News
for HES1

Publications
for HES1

Search for HES1

Genome Databases showing HES1

Other Databases showing HES1

Specialized Databases showing HES1

Licensable Technologies
for HES1

Services
for HES1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HES1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor HES1

Summariesfor HES1

Genomic Locationfor HES1

Proteinsfor HES1

Protein Domains/Familiesfor HES1

Gene Functionfor HES1

Pathways & Interactionsfor HES1

Drugs & Compoundsfor HES1

Transcriptsfor HES1

Expression for HES1

Orthologsfor HES1

Paralogsfor HES1

SNPs/Variantsfor HES1

Disorders & Mutationsfor HES1

Medical Newsfor HES1

Publicationsfor HES1

Search for HES1

Genome Databases showing HES1

Other Databases showing HES1

Specialized Databases showing HES1

Licensable Technologiesfor HES1

Servicesfor HES1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HES1

Summaries
for HES1

Genomic Location
for HES1

Proteins
for HES1

Protein Domains/
Families
for HES1

Gene Function
for HES1

Pathways & Interactions
for HES1

Drugs & Compounds
for HES1

Transcripts
for HES1

Expression
for HES1

Orthologs
for HES1

Paralogs
for HES1

SNPs/Variants
for HES1

Disorders & Mutations
for HES1

Medical News
for HES1

Publications
for HES1

Licensable Technologies
for HES1

Services
for HES1