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Aliases for HES1 Gene

Aliases for HES1 Gene

  • Hes Family BHLH Transcription Factor 1 2 3
  • HRY 3 4 6
  • Class B Basic Helix-Loop-Helix Protein 39 3 4
  • Hairy-Like Protein 3 4
  • Hairy Homolog 3 4
  • BHLHb39 3 4
  • HHL 3 4
  • Hairy And Enhancer Of Split 1, (Drosophila) 2
  • Hairy And Enhancer Of Split 1 4
  • Hairy Homolog (Drosophila) 2
  • Transcription Factor HES-1 3
  • HES-1 3
  • HL 4

External Ids for HES1 Gene

Previous HGNC Symbols for HES1 Gene

  • HRY

Previous GeneCards Identifiers for HES1 Gene

  • GC03P195130
  • GC03P195255
  • GC03P195174
  • GC03P195336
  • GC03P193853
  • GC03P191241

Summaries for HES1 Gene

Entrez Gene Summary for HES1 Gene

  • This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

GeneCards Summary for HES1 Gene

HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HES5.

UniProtKB/Swiss-Prot for HES1 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5-CACNAG-3 with high affinity and on E-box motifs: 5-CANNTG-3 with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

Gene Wiki entry for HES1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES1 Gene

Genomics for HES1 Gene

Regulatory Elements for HES1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HES1 Gene

Start:
194,136,142 bp from pter
End:
194,138,732 bp from pter
Size:
2,591 bases
Orientation:
Plus strand

Genomic View for HES1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES1 Gene

Proteins for HES1 Gene

  • Protein details for HES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14469-HES1_HUMAN
    Recommended name:
    Transcription factor HES-1
    Protein Accession:
    Q14469
    Secondary Accessions:
    • Q6FHB2

    Protein attributes for HES1 Gene

    Size:
    280 amino acids
    Molecular mass:
    29541 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE.

    Three dimensional structures from OCA and Proteopedia for HES1 Gene

neXtProt entry for HES1 Gene

Proteomics data for HES1 Gene at MOPED

Post-translational modifications for HES1 Gene

  • Ubiquitination at Lys86 and Lys109
  • Modification sites at PhosphoSitePlus

Other Protein References for HES1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HES1 (HES1)

No data available for DME Specific Peptides for HES1 Gene

Domains for HES1 Gene

Gene Families for HES1 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for HES1 Gene

Suggested Antigen Peptide Sequences for HES1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14469

UniProtKB/Swiss-Prot:

HES1_HUMAN :
  • Q14469
Domain:
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG)
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
genes like me logo Genes that share domains with HES1: view

Function for HES1 Gene

Molecular function for HES1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5-CACNAG-3 with high affinity and on E-box motifs: 5-CANNTG-3 with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

Gene Ontology (GO) - Molecular Function for HES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS --
GO:0003677 DNA binding TAS 7906273
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 17681138
GO:0005515 protein binding IPI 12535671
genes like me logo Genes that share ontologies with HES1: view
genes like me logo Genes that share phenotypes with HES1: view

Animal Models for HES1 Gene

MGI Knock Outs for HES1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HES1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HES1 Gene

Localization for HES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HES1 Gene COMPARTMENTS Subcellular localization image for HES1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HES1: view

Pathways for HES1 Gene

genes like me logo Genes that share pathways with HES1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12032823
GO:0001701 in utero embryonic development --
GO:0001889 liver development IEA --
GO:0003143 embryonic heart tube morphogenesis ISS --
GO:0003151 outflow tract morphogenesis ISS --
genes like me logo Genes that share ontologies with HES1: view

Compounds for HES1 Gene

(6) Novoseek inferred chemical compound relationships for HES1 Gene

Compound -log(P) Hits PubMed IDs
tetrapeptide 19.8 2
retinoic acid 18 7
12-o-tetradecanoylphorbol 13-acetate 4.48 1
oligonucleotide 0 1
glycogen 0 1
genes like me logo Genes that share compounds with HES1: view

Transcripts for HES1 Gene

mRNA/cDNA for HES1 Gene

Unigene Clusters for HES1 Gene

Hairy and enhancer of split 1, (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HES1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES1 Gene

No ASD Table

Relevant External Links for HES1 Gene

GeneLoc Exon Structure for
HES1
ECgene alternative splicing isoforms for
HES1

Expression for HES1 Gene

mRNA expression in normal human tissues for HES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HES1 Gene

SOURCE GeneReport for Unigene cluster for HES1 Gene Hs.250666

genes like me logo Genes that share expressions with HES1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HES1 Gene

Orthologs for HES1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HES1 35
  • 99.88 (n)
  • 100 (a)
HES1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HES1 35
  • 93.81 (n)
  • 99.64 (a)
HES1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hes1 35
  • 89.76 (n)
  • 94.64 (a)
Hes1 16
Hes1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HES1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HES1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hes1 35
  • 90.71 (n)
  • 95.71 (a)
chicken
(Gallus gallus)
Aves CHAIRY-1 36
  • 60 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC397813 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hes1 35
  • 71.05 (n)
  • 77.82 (a)
Str.10866 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.686 35
zebrafish
(Danio rerio)
Actinopterygii her6 35
  • 69.41 (n)
  • 76.78 (a)
her9 36
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta dpn 36
  • 22 (a)
ManyToMany
h 36
  • 28 (a)
ManyToMany
Side 36
  • 18 (a)
ManyToMany
Species with no ortholog for HES1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES1 Gene

ENSEMBL:
Gene Tree for HES1 (if available)
TreeFam:
Gene Tree for HES1 (if available)

Paralogs for HES1 Gene

Paralogs for HES1 Gene

Selected SIMAP similar genes for HES1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HES1: view

Variants for HES1 Gene

Sequence variations from dbSNP and Humsavar for HES1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2005634 -- 194,137,278(+) CGGGT(A/C)GGGGC intron-variant
rs2236747 -- 194,136,868(+) GAGAT(A/C)ATGCT intron-variant
rs2368048 -- 194,137,172(+) ACTCT(C/T)GCGTT intron-variant
rs4072027 -- 194,137,441(+) CAGAT(C/G)TGGGG intron-variant
rs4350871 -- 194,134,682(+) TGAAA(A/G)AATTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HES1 Gene

Variant ID Type Subtype PubMed ID
nsv878126 CNV Loss 21882294
nsv822397 CNV Gain 20364138
nsv822399 CNV Gain 20364138
nsv822400 CNV Gain 20364138

Relevant External Links for HES1 Gene

HapMap Linkage Disequilibrium report
HES1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES1 Gene

Disorders for HES1 Gene

(15) Novoseek inferred disease relationships for HES1 Gene

Disease -log(P) Hits PubMed IDs
t-all 70.3 2
leukemia 28.1 1
medulloblastoma 23.5 1
tumors 22.2 14
carcinoid 13.7 6

Relevant External Links for HES1

Genetic Association Database (GAD)
HES1
Human Genome Epidemiology (HuGE) Navigator
HES1
genes like me logo Genes that share disorders with HES1: view

No data available for UniProtKB/Swiss-Prot for HES1 Gene

Publications for HES1 Gene

  1. HES1 is a novel interactor of the Fanconi anemia core complex. (PMID: 18550849) Tremblay C.S. … Carreau M. (Blood 2008) 3 4 23
  2. Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. (PMID: 8020957) Feder J.N. … Jan Y.-N. (Genomics 1994) 2 3 4
  3. Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway. (PMID: 19808903) Lee J.H. … Joe C.O. (Mol. Cancer Res. 2009) 3 23
  4. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. (PMID: 19861684) Nakahara F. … Chiba S. (Blood 2010) 3 23
  5. Estrogen-dependent downregulation of hairy and enhancer of split homolog-1 gene expression in breast cancer cells is mediated via a 3' distal element. (PMID: 19039095) MA1ller P. … StrAPm A. (J. Endocrinol. 2009) 3 23

Products for HES1 Gene

  • Addgene plasmids for HES1

Sources for HES1 Gene

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