Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HERPUD2 Gene

Aliases for HERPUD2 Gene

  • HERPUD Family Member 2 2 3
  • Endoplasmic Reticulum Stress-Inducible 2
  • Ubiquitin-Like Domain Member 2 2
  • Homocysteine-Inducible 2

External Ids for HERPUD2 Gene

Previous GeneCards Identifiers for HERPUD2 Gene

  • GC07M035638

Summaries for HERPUD2 Gene

GeneCards Summary for HERPUD2 Gene

HERPUD2 (HERPUD Family Member 2) is a Protein Coding gene. An important paralog of this gene is HERPUD1.

UniProtKB/Swiss-Prot for HERPUD2 Gene

  • Could be involved in the unfolded protein response (UPR) pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERPUD2 Gene

Genomics for HERPUD2 Gene

Regulatory Elements for HERPUD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HERPUD2 Gene

35,632,659 bp from pter
35,695,571 bp from pter
62,913 bases
Minus strand

Genomic View for HERPUD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HERPUD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERPUD2 Gene

Proteins for HERPUD2 Gene

  • Protein details for HERPUD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
    Protein Accession:
    Secondary Accessions:
    • A4D1Y8
    • Q9H6F9

    Protein attributes for HERPUD2 Gene

    406 amino acids
    Molecular mass:
    45147 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HERPUD2 Gene

neXtProt entry for HERPUD2 Gene

Proteomics data for HERPUD2 Gene at MOPED

Post-translational modifications for HERPUD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HERPUD2 Gene

Antibody Products

No data available for DME Specific Peptides for HERPUD2 Gene

Domains for HERPUD2 Gene

Protein Domains for HERPUD2 Gene

Suggested Antigen Peptide Sequences for HERPUD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BSE4
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with HERPUD2: view

No data available for Gene Families for HERPUD2 Gene

Function for HERPUD2 Gene

Molecular function for HERPUD2 Gene

UniProtKB/Swiss-Prot Function:
Could be involved in the unfolded protein response (UPR) pathway.

Gene Ontology (GO) - Molecular Function for HERPUD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HERPUD2: view

Animal Model Products

CRISPR Products

miRNA for HERPUD2 Gene

miRTarBase miRNAs that target HERPUD2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HERPUD2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HERPUD2 Gene

Localization for HERPUD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERPUD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HERPUD2 Gene COMPARTMENTS Subcellular localization image for HERPUD2 gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for HERPUD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HERPUD2: view

Pathways for HERPUD2 Gene

SuperPathways for HERPUD2 Gene

No Data Available

Interacting Proteins for HERPUD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000310729 for HERPUD2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for HERPUD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with HERPUD2: view

No data available for Pathways by source for HERPUD2 Gene

Transcripts for HERPUD2 Gene

Unigene Clusters for HERPUD2 Gene

HERPUD family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HERPUD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HERPUD2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP2: -
SP4: - -
SP5: -
SP6: - - -
SP7: - - -
SP8: - -

Relevant External Links for HERPUD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HERPUD2 Gene

mRNA expression in normal human tissues for HERPUD2 Gene

Protein differential expression in normal tissues for HERPUD2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HERPUD2 Gene

SOURCE GeneReport for Unigene cluster for HERPUD2 Gene Hs.643051

genes like me logo Genes that share expressions with HERPUD2: view

Expression partners for HERPUD2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HERPUD2 Gene

Orthologs for HERPUD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HERPUD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HERPUD2 35
  • 94.75 (n)
  • 94.09 (a)
  • 94 (a)
(Canis familiaris)
Mammalia HERPUD2 35
  • 95.32 (n)
  • 95.32 (a)
  • 95 (a)
(Mus musculus)
Mammalia Herpud2 35
  • 89.85 (n)
  • 89.85 (a)
Herpud2 16
Herpud2 36
  • 90 (a)
(Pan troglodytes)
Mammalia HERPUD2 35
  • 99.75 (n)
  • 99.75 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Herpud2 35
  • 89.36 (n)
  • 89.78 (a)
(Monodelphis domestica)
Mammalia HERPUD2 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia HERPUD2 36
  • 73 (a)
(Gallus gallus)
Aves HERPUD2 35
  • 76.05 (n)
  • 76.05 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia HERPUD2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia herpud2 35
  • 65.83 (n)
  • 61.06 (a)
Str.6501 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52715 35
(Danio rerio)
Actinopterygii herpud2 35
  • 61 (n)
  • 58.76 (a)
zgc56020 35
herpud2 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Herp 35
  • 47.46 (n)
  • 38.78 (a)
Herp 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3209 36
  • 35 (a)
Species with no ortholog for HERPUD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HERPUD2 Gene

Gene Tree for HERPUD2 (if available)
Gene Tree for HERPUD2 (if available)

Paralogs for HERPUD2 Gene

Paralogs for HERPUD2 Gene

Selected SIMAP similar genes for HERPUD2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HERPUD2: view

Variants for HERPUD2 Gene

Sequence variations from dbSNP and Humsavar for HERPUD2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs725471 -- 35,668,294(+) CAAGA(G/T)GTTAA intron-variant
rs896173 -- 35,695,927(-) TCAAC(C/T)TTTTG upstream-variant-2KB
rs896174 -- 35,695,583(-) CCATG(C/G)CTTCT upstream-variant-2KB
rs1026198 -- 35,674,382(+) ACCta(C/T)atata intron-variant
rs1116211 -- 35,652,324(+) caacc(C/T)gcaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HERPUD2 Gene

Variant ID Type Subtype PubMed ID
nsv471638 CNV Gain 15918152
nsv5697 CNV Loss 18451855
nsv527371 CNV Gain 19592680
dgv419n21 CNV Gain 19592680
nsv5699 CNV Insertion 18451855
esv2659669 CNV Deletion 23128226
esv1619444 CNV Deletion 17803354

Relevant External Links for HERPUD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HERPUD2 Gene

Disorders for HERPUD2 Gene

Relevant External Links for HERPUD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HERPUD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HERPUD2 Gene

Publications for HERPUD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for HERPUD2 Gene

Sources for HERPUD2 Gene

Back to Top