Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HERPUD1 Gene

protein-coding GIFtS: 60
GCID: GC16P056965

homocysteine-inducible, endoplasmic reticulum stress-inducible,...

Explore 14 diseases affiliated with
HERPUD1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 1¹ ²		Methyl Methanesulfonate (MMF)-Inducible Fragment Protein 1² ³
HERP¹ ² ³ ⁵		MIF1³ ⁵
KIAA0025¹ ³ ⁵		MMS-Inducible¹
Mif1¹ ²		Homocysteine-Inducible Endoplasmic Reticulum Stress-Inducible Ubiquitin-Like Domain Member 1 Protein²
SUP¹ ²		Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 Protein²

External Ids:	HGNC: 13744¹	Entrez Gene: 9709²	Ensembl: ENSG00000051108⁷	OMIM: 608070⁵	UniProtKB: Q15011³

Export aliases for HERPUD1 gene to outside databases

Previous GC identifers: GC16M047322 GC16P057017 GC16P056700 GC16P056741 GC16P055523 GC16P042835

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HERPUD1:

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response

includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression

of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of

misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and

ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the

encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been

shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its

overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

The full-length nature of all transcript variants has not been determined. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011

Function: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation

(ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance

presenilin-mediated beta-amyloid protein 40 generation

Gene Wiki entry for HERPUD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HERPUD1 gene promoter:
CREB deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HERPUD1 promoter sequence

Search SABiosciences Chromatin IP Primers for HERPUD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HERPUD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q13 HGNC cytogenetic band: 16q13

HERPUD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HERPUD1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P056965: view genomic region (about GC identifiers)

Start:	56,965,748 bp from pter	End:	56,977,798 bp from pter
Size:	12,051 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011 (See protein sequence)

Recommended Name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Size: 391 amino acids; 43720 Da

Subunit: Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Miscellaneous: Although the precise topology is not known, experimental data suggest that both the N- and C-termini

face the cytosol

1 PDB 3D structure from and Proteopedia for HERPUD1:

1WGD (3D)

Secondary accessions: O60644 Q6IAN8 Q96D92

Alternative splicing: 3 isoforms: Q15011-1 Q15011-2 Q15011-3

Explore the universe of human proteins at neXtProt for HERPUD1: NX_Q15011

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15011

HERPUD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001010989.1 NP_001259032.1 NP_055500.1 NP_001010990.1

ENSEMBL proteins:

ENSP00000409555 ENSP00000456384 ENSP00000340931 ENSP00000300302 ENSP00000369118

ENSP00000457321 ENSP00000455094 ENSP00000457095 ENSP00000455841 ENSP00000457955

Reactome Protein details: Q15011
Human Recombinant Protein Products for HERPUD1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: HERPUD1 OriGene Protein Over-expression Lysate (see all 4): HERPUD1 OriGene Custom Protein Services for HERPUD1
	GenScript Custom Purified and Recombinant Proteins Services for HERPUD1
	Novus Biologicals HERPUD1 Proteins Novus Biologicals HERPUD1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HERPUD1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

HERPUD1 for ontologies About GeneDecksing

HERPUD1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HERPUD1
	GenScript Custom Superior Antibodies Services for HERPUD1
	Novus Biologicals HERPUD1 Antibodies
	Abcam antibodies for HERPUD1
	Uscn Antibodies for HERPUD1
	Search ThermoFisher Antibodies for HERPUD1

Assay Products for HERPUD1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HERPUD1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HERPUD1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HERPUD1 for domains About GeneDecksing

2 InterPro domains/families:

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry Q15011

ProtoNet protein and cluster: Q15011

1 Blocks protein family: IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011

Similarity: Contains 1 ubiquitin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HERP1_HUMAN, Q15011

Function: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation

(ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance

presenilin-mediated beta-amyloid protein 40 generation

Induction: Up-regulated by endoplasmic reticulum stress and CREB3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	--	--

HERPUD1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HERPUD1

miRNA Products:		miRTarBase miRNAs that target HERPUD1: hsa-mir-373 (MIRT002508)

		OriGene 3'-UTR Clone (see all 3): HERPUD1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HERPUD1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate HERPUD1:
		hsa-miR-9* hsa-miR-543
		SwitchGear 3'UTR luciferase reporter plasmid: HERPUD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HERPUD1 (see all 7) OriGene shRNA RFP: HERPUD1 OriGene siRNA: HERPUD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HERPUD1
		Sirion Biotech Custom design and validation of potent shRNA sequences against HERPUD1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HERPUD1
			Sirion Biotech Customized adenovirus for overexpression of HERPUD1 Sirion Biotech Customized adenovirus for potent knockdown of HERPUD1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HERPUD1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HERPUD1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): HERPUD1 (NM_014685)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HERPUD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERPUD1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HERPUD1
		Search LifeMap BioReagents cell lines for HERPUD1
		Sirion Biotech Customized stable knockdown cell line services for HERPUD1 Sirion Biotech Customized inducible knockdown cell line services for HERPUD1 Sirion Biotech Customized stable overexpressing cell line services for HERPUD1 Sirion Biotech Customized inducible overexpressing cell line services for HERPUD1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERPUD1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of Genes by ATF4

Activation of Genes by ATF4

1.00

PERK regulated gene expression

0.64

Expression of HERPUD

Expression of HERPUD

1.00

Diurnally regulated genes with circadian orthologs

Diurnally regulated genes with circadian orthologs

1.00

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

1.00

Activation of Chaperone Genes by XBP1(S)

Unfolded Protein Response

0.71

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for HERPUD1

Diurnally regulated genes with circadian orthologs

5 Reactome Pathways for HERPUD1

	Expression of HERPUD
	PERK regulated gene expression
	Metabolism of proteins
	Activation of Genes by ATF4
	Unfolded Protein Response

1 Kegg Pathway (Kegg details for HERPUD1):

Protein processing in endoplasmic reticulum

HERPUD1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HERPUD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/31 Interacting proteins for HERPUD1 (Q15011^{2, 3} ENSP00000300302⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XRCC6	P12956²^,³, ENSP00000352257⁴	MINT-8258131 I2D: score=2 STRING: ENSP00000352257
USP7	Q93009²^,³, ENSP00000343535⁴	MINT-2867316 I2D: score=3 STRING: ENSP00000343535
ARHGDIA	P52565²^,³, ENSP00000269321⁴	MINT-8258120 I2D: score=2 STRING: ENSP00000269321
IMPA2	O14732³, ENSP00000269159⁴	I2D: score=3 STRING: ENSP00000269159
PSEN1	P49768³, ENSP00000326366⁴	I2D: score=3 STRING: ENSP00000326366

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	--
GO:0006874	cellular calcium ion homeostasis	IEA	--
GO:0006950	response to stress	--	--
GO:0006986	response to unfolded protein	IEP	10922362
GO:0006987	activation of signaling protein activity involved in unfolded protein response	TAS	--

HERPUD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HERPUD1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HERPUD1
2 Novoseek chemical compound relationships for HERPUD1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tunicamycin	55.4	4	10708769 (2), 10922362 (1)
homocysteine	42.7	13	17020760 (6), 20164556 (2), 10922362 (1)

Search CenterWatch for drugs/clinical trials and news about HERPUD1 / HERP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HERPUD1 gene (4 alternative transcripts):

NM_001010989.2 NM_001272103.1 NM_014685.3 NM_001010990.1

Unigene Cluster for HERPUD1:

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Hs.146393 [show with all ESTs]

Unigene Representative Sequence: AF217990

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000439977(uc002eke.1 uc002ekf.1 uc002ekg.1 uc010cco.1 uc010ccp.1)

ENST00000562914 ENST00000568676 ENST00000569569(uc010vhj.1) ENST00000565966

ENST00000344114 ENST00000300302 ENST00000570273 ENST00000379792 ENST00000569429

ENST00000563343 ENST00000566550 ENST00000563781 ENST00000568358 ENST00000564678(uc002ekh.1)

ENST00000563911 ENST00000567944 ENST00000568651

miRNA Products:		OriGene 3'-UTR Clone (see all 3): HERPUD1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HERPUD1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate HERPUD1:
		hsa-miR-9* hsa-miR-543
		SwitchGear 3'UTR luciferase reporter plasmid: HERPUD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HERPUD1 (see all 7) OriGene shRNA RFP: HERPUD1 OriGene siRNA: HERPUD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HERPUD1
		Sirion Biotech Custom design and validation of potent shRNA sequences against HERPUD1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HERPUD1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HERPUD1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): HERPUD1 (NM_014685)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HERPUD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERPUD1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HERPUD1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HERPUD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HERPUD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HERPUD1

Additional cDNA sequence:

AB034989.1 AF055001.1 AF055003.1 AF217990.1 AK223233.1 AK291565.1 AK292088.1 AK302167.1

AK304800.1 BC000086.1 BC008320.1 BC009739.1 BC032673.1 CR457116.1 D14695.1 DQ837586.1

24/28 DOTS entries (see all 28):

DT.119762 DT.92064876 DT.91913405 DT.100690353 DT.97867781 DT.119765 DT.120683566 DT.120683560

DT.91913364 DT.95131850 DT.100044140 DT.120683520 DT.120683563 DT.40123628 DT.86994662 DT.95351209

DT.100736730 DT.100832578 DT.120683524 DT.120683536 DT.75169426 DT.91913615 DT.91990600 DT.100690411

24/684 AceView cDNA sequences (see all 684):

BQ447946 BU156948 F03839 BP337747 AI474455 CA435725 BM673314 CA446941

AB034989 AF217990 AI287330 BF058149 CB306441 AI369436 AA350128 AW338361

BM985115 AW135359 BU736855 AA988993 AI097015 AU121453 CD368546 BM707911

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HERPUD1 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	·	9d
SP1:							-						-		-		-		-						-
SP2:							-						-		-		-		-						-
SP3:							-						-		-		-		-						-		-		-		-		-		-
SP4:							-				-		-		-		-		-						-
SP5:																									-

ECgene alternative splicing isoforms for HERPUD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HERPUD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTAGCAGG

About this image

HERPUD1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Extraembryonic endoderm-like cells (Generation of extrae...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HERPUD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HERPUD1

SOURCE GeneReport for Unigene cluster: Hs.146393

UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011

Tissue specificity: Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth

muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease

SABiosciences Expression via Pathway-Focused PCR Arrays including HERPUD1:

TGFB/BMP Signaling Pathway in human mouse rat

TGFB Signaling Targets in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HERPUD1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HERPUD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HERPUD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HERPUD1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERPUD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HERPUD1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Herpud1^{1 , 5}	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 less^{1, 5}	86.79(n)¹ 88.75(a)¹		8 (46.46 cM)⁵ 64209¹ NM_022331.1¹ NP_071726.1¹ 94386438⁵
chicken (Gallus gallus)	Aves	HERPUD1¹	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 less	65.04(n) 58.15(a)		415644 XM_414010.3 XP_414010.3
lizard (Anolis carolinensis)	Reptilia	HERPUD1⁶	--	53(a)	1 ↔ 1	GL344281.1(976-6199)
African clawed frog (Xenopus laevis)	Amphibia	herpud1-A-prov²	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 less	75.59(n)		BC046268.1
zebrafish (Danio rerio)	Actinopterygii	Dr.9626²	Transcribed sequence with weak similarity to protein spQ15011 (H.sapiens) HERP_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1) less	75.4(n)		CA470363.1
fruit fly (Drosophila melanogaster)	Insecta	Herp⁶	Homocysteine-induced endoplasmic reticulum protein...	22(a)	1 → many	2L(7796308-7799846)
worm (Caenorhabditis elegans)	Secernentea	tag-353⁶	Temporarily Assigned Gene name family member (tag-...	21(a)	1 → many	I(10401058-10402765)

ENSEMBL Gene Tree for HERPUD1 (if available)
TreeFam Gene Tree for HERPUD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HERPUD1 gene

HERPUD2²

1 SIMAP similar gene for HERPUD1 using alignment to 9 protein entries: HERP1_HUMAN (see all proteins):

HERPUD2

HERPUD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9938413^1,2	C,F,A,H	--	42841578(+)	`gtgggC/Tggatc`	1	--	us2k¹		2		NA	4
rs79099545^1,2	F	--	42842158(+)	`CCTGCA/CGTGAG`	1	--	us2k¹		1		WA	118
rs2270835^1,2	C,F,H	--	42842376(+)	`TCTTCT/CGTCTC`	1	--	us2k¹		25		EA NS NA WA CSA	3814
rs112699546^1,2	C	--	42844125(+)	`GAGGCC/TGAGGC`	1	--	int¹		1		WA	2
rs3903056^1,2	C,F	--	42844277(-)	`cccagT/Ctcaag`	1	--	nc-transcript-variant		4		NA WA	8
rs116184163^1,2	C,F	--	42844441(+)	`ACATAT/GCAATC`	1	--	nc-transcript-variant		1		WA	118
rs77542462^1,2	C,F	--	42844694(+)	`GGCCCG/AAAGCA`	1	--	nc-transcript-variant		1		WA	118
rs73561722^1,2	C	--	42844845(+)	`TCTACC/AATGCA`	1	--	nc-transcript-variant		1		WA	2
rs75874809^1,2	F	--	42845335(+)	`GAATAA/CAACAC`	1	--	ds500¹		1		WA	118
rs189644197^1,2		--	56963785(+)	`GAGGCA/GAGGAG`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HERPUD1 (56965748 - 56977798 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HERPUD1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HERPUD1

DNA2.0 Custom Variant and Variant Library Synthesis for HERPUD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HERPUD1 for disorders           About GeneDecksing

OMIM gene information: 608070    OMIM disorders: --

14 diseases for HERPUD1:    About MalaCards

homocysteine inclusion body myositis lupus nephritis myositis

myocardial infarction nephritis hyperhomocysteinemia parkinson's disease

alzheimer's disease neurodegeneration psoriasis ataxia

cholesterol neuronitis

Human Genome Epidemiology (HuGE) Navigator: HERPUD1 (2 documents)

Export disorders for HERPUD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HERPUD1 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with HERPUD1)

Utopia: connect your pdf to the dynamic
world of online information

Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. (PubMed id 10922362)^{1, 2, 3, 9} Kokame K.... Miyata T. (2000)
The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway. (PubMed id 10708769)^{1, 2, 3, 9} van Laar T....Terleth C. (2000)
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. (PubMed id 11799129)^{1, 2, 9} Sai X.... Komano H. (2002)
Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. (PubMed id 11112790)^{1, 2, 9} Kokame K.... Miyata T. (2001)
The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. (PubMed id 16289116)^{1, 2, 9} Schulze A.... Seeger M. (2005)
Ubxd1 is a novel co-factor of the human p97 ATPase. (PubMed id 18656546)^{1, 2} Madsen L....Hartmann-Petersen R. (2008)
Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. (PubMed id 16940180)^{1, 2} Liang G....Lu R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{1, 2} Nomura N.... Tabata S. (1994)
The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid beta-protein generation. (PubMed id 14550564)^{1, 9} Sai X....Komano H. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9709	HGNC: 13744	AceView: HERPUD1	Ensembl:ENSG00000051108	euGenes: HUgn9709
ECgene: HERPUD1	Kegg: 9709	H-InvDB: HERPUD1

(According to HUGE)
About This Section

HUGE: KIAA0025

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HERPUD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HERPUD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HERPUD1 gene:
Search GeneIP for patents involving HERPUD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HERPUD1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HERPUD1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HERPUD1
	OriGene Protein Over-expression Lysate for HERPUD1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HERPUD1		OriGene 3'-UTR Clone for HERPUD1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HERPUD1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HERPUD1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HERPUD1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HERPUD1		OriGene Custom Protein Services for HERPUD1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HERPUD1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HERPUD1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HERPUD1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HERPUD1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HERPUD1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HERPUD1

	GenScript Custom Purified and Recombinant Proteins Services for HERPUD1		GenScript cDNA clones with any tag delivered in your preferred vector for HERPUD1
	GenScript Custom Assay Services for HERPUD1		GenScript Custom Superior Antibodies Services for HERPUD1
	GenScript Custom overexpressing Cell Line Services for HERPUD1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HERPUD1 promoter
	Search Chromatin IP Primers for HERPUD1
	RT² qPCR Primer Assay in human, mouse, rat HERPUD1
	GNC Network for HERPUD1
	SABiosciences PCR Arrays including human, mouse, rat HERPUD1

Search Tocris compounds for HERPUD1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HERPUD1 antibodies
	HERPUD1 proteins
	HERPUD1 lysates

	Antibodies for HERPUD1
	See all of Abcam's Antibodies, Kits and Proteins for HERPUD1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HERPUD1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HERPUD1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERPUD1

	SwitchGear 3'UTR luciferase reporter plasmids for HERPUD1
	SwitchGear Promoter luciferase reporter plasmids for HERPUD1

Search ThermoFisher Antibodies for HERPUD1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERPUD1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HERPUD1

Sirion Biotech Customized:

	stable knockdown cell line services for HERPUD1
	inducible knockdown cell line services for HERPUD1
	design and validation of potent shRNA sequences against HERPUD1
	adenovirus for potent knockdown of HERPUD1
	adenovirus for overexpression of HERPUD1
	stable overexpressing cell line services for HERPUD1
	inducible overexpressing cell line services for HERPUD1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HERPUD1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

HERPUD1 Gene

homocysteine-inducible, endoplasmic reticulum stress-inducible,...

Aliases
for HERPUD1 gene

Summaries
for HERPUD1 gene

Genomic Views
for HERPUD1 gene

Proteins
for HERPUD1 gene

Protein Domains /
Families
for HERPUD1 gene

Function
for HERPUD1 gene

Pathways & Interactions
for HERPUD1 gene

Drugs & Compounds
for HERPUD1 gene

Transcripts
for HERPUD1 gene

Expression
for HERPUD1 gene

Orthologs
for HERPUD1 gene

Paralogs
for HERPUD1 gene

Genomic Variants
for HERPUD1 gene

Disorders / Diseases
for HERPUD1 gene

Publications
for HERPUD1 gene

External Searches for HERPUD1 gene

Genome Databases showing HERPUD1 gene

Other Databases showing HERPUD1 gene

Specialized Databases showing HERPUD1 gene

Intellectual Property
for HERPUD1 gene

Products
for HERPUD1 gene

View Random Gene

Advanced Search

Export list of displayed genes

HERPUD1 Gene

homocysteine-inducible, endoplasmic reticulum stress-inducible,...

Aliasesfor HERPUD1 gene

Summariesfor HERPUD1 gene

Genomic Viewsfor HERPUD1 gene

Proteinsfor HERPUD1 gene

Protein Domains /Familiesfor HERPUD1 gene

Functionfor HERPUD1 gene

Pathways & Interactionsfor HERPUD1 gene

Drugs & Compoundsfor HERPUD1 gene

Transcriptsfor HERPUD1 gene

Expression for HERPUD1 gene

Orthologsfor HERPUD1 gene

Paralogsfor HERPUD1 gene

Genomic Variantsfor HERPUD1 gene

Disorders / Diseasesfor HERPUD1 gene

Publicationsfor HERPUD1 gene

External Searches for HERPUD1 gene

Genome Databases showing HERPUD1 gene

Other Databases showing HERPUD1 gene

Specialized Databases showing HERPUD1 gene

Intellectual Propertyfor HERPUD1 gene

Productsfor HERPUD1 gene

View Random Gene

Aliases
for HERPUD1 gene

Summaries
for HERPUD1 gene

Genomic Views
for HERPUD1 gene

Proteins
for HERPUD1 gene

Protein Domains /
Families
for HERPUD1 gene

Function
for HERPUD1 gene

Pathways & Interactions
for HERPUD1 gene

Drugs & Compounds
for HERPUD1 gene

Transcripts
for HERPUD1 gene

Expression
for HERPUD1 gene

Orthologs
for HERPUD1 gene

Paralogs
for HERPUD1 gene

Genomic Variants
for HERPUD1 gene

Disorders / Diseases
for HERPUD1 gene

Publications
for HERPUD1 gene

Intellectual Property
for HERPUD1 gene

Products
for HERPUD1 gene