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Aliases for HERPUD1 Gene

Aliases for HERPUD1 Gene

  • Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1 2 3
  • Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 1 2 3 5
  • Methyl Methanesulfonate (MMF)-Inducible Fragment Protein 1 3 4
  • Mif1 3 4
  • HERP 3 4
  • Homocysteine-Inducible Endoplasmic Reticulum Stress-Inducible Ubiquitin-Like Domain Member 1 Protein 3
  • MMS-Inducible 3
  • KIAA0025 4
  • SUP 3

External Ids for HERPUD1 Gene

Previous GeneCards Identifiers for HERPUD1 Gene

  • GC16M047322
  • GC16P057017
  • GC16P056700
  • GC16P056741
  • GC16P055523
  • GC16P042835

Summaries for HERPUD1 Gene

Entrez Gene Summary for HERPUD1 Gene

  • The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]

GeneCards Summary for HERPUD1 Gene

HERPUD1 (Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1) is a Protein Coding gene. Diseases associated with HERPUD1 include Subclavian Steal Syndrome. Among its related pathways are Diurnally regulated genes with circadian orthologs and PERK regulates gene expression. GO annotations related to this gene include ion channel binding. An important paralog of this gene is HERPUD2.

UniProtKB/Swiss-Prot for HERPUD1 Gene

  • Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).

Gene Wiki entry for HERPUD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERPUD1 Gene

Genomics for HERPUD1 Gene

Regulatory Elements for HERPUD1 Gene

Enhancers for HERPUD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HERPUD1 on UCSC Golden Path with GeneCards custom track

Promoters for HERPUD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HERPUD1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HERPUD1 gene promoter:

Genomic Location for HERPUD1 Gene

Chromosome:
16
Start:
56,931,765 bp from pter
End:
56,944,863 bp from pter
Size:
13,099 bases
Orientation:
Plus strand

Genomic View for HERPUD1 Gene

Genes around HERPUD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HERPUD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HERPUD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERPUD1 Gene

Proteins for HERPUD1 Gene

  • Protein details for HERPUD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15011-HERP1_HUMAN
    Recommended name:
    Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Protein Accession:
    Q15011
    Secondary Accessions:
    • E9PGD1
    • O60644
    • Q6IAN8
    • Q96D92

    Protein attributes for HERPUD1 Gene

    Size:
    391 amino acids
    Molecular mass:
    43720 Da
    Quaternary structure:
    • Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6. Interacts with UBQLN1, UBQLN2 and UBQLN4.
    Miscellaneous:
    • Although the precise topology is not known, experimental data suggest that both the N- and C-termini face the cytosol.

    Three dimensional structures from OCA and Proteopedia for HERPUD1 Gene

    Alternative splice isoforms for HERPUD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HERPUD1 Gene

Proteomics data for HERPUD1 Gene at MOPED

Post-translational modifications for HERPUD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HERPUD1 (HERPUD1)

No data available for DME Specific Peptides for HERPUD1 Gene

Domains & Families for HERPUD1 Gene

Protein Domains for HERPUD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15011

UniProtKB/Swiss-Prot:

HERP1_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with HERPUD1: view

No data available for Gene Families for HERPUD1 Gene

Function for HERPUD1 Gene

Molecular function for HERPUD1 Gene

UniProtKB/Swiss-Prot Function:
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).
UniProtKB/Swiss-Prot Induction:
Up-regulated by endoplasmic reticulum stress and CREB3.

Phenotypes for HERPUD1 Gene

genes like me logo Genes that share phenotypes with HERPUD1: view

Animal Models for HERPUD1 Gene

MGI Knock Outs for HERPUD1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HERPUD1 Gene

Localization for HERPUD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERPUD1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HERPUD1 Gene COMPARTMENTS Subcellular localization image for HERPUD1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
nucleus 3
mitochondrion 2
plasma membrane 2
chloroplast 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HERPUD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HERPUD1: view

Pathways & Interactions for HERPUD1 Gene

genes like me logo Genes that share pathways with HERPUD1: view

Pathways by source for HERPUD1 Gene

SIGNOR curated interactions for HERPUD1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HERPUD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0031396 regulation of protein ubiquitination IEA --
GO:0032092 positive regulation of protein binding IEA --
GO:0032469 endoplasmic reticulum calcium ion homeostasis IDA 15102845
genes like me logo Genes that share ontologies with HERPUD1: view

Drugs & Compounds for HERPUD1 Gene

(2) Additional Compounds for HERPUD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HERPUD1: view

Transcripts for HERPUD1 Gene

Unigene Clusters for HERPUD1 Gene

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HERPUD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: - - - -
SP8: -
SP9: -
SP10:
SP11:

Relevant External Links for HERPUD1 Gene

GeneLoc Exon Structure for
HERPUD1
ECgene alternative splicing isoforms for
HERPUD1

Expression for HERPUD1 Gene

mRNA expression in normal human tissues for HERPUD1 Gene

Protein differential expression in normal tissues from HIPED for HERPUD1 Gene

This gene is overexpressed in Bone (46.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HERPUD1 Gene



SOURCE GeneReport for Unigene cluster for HERPUD1 Gene Hs.146393

mRNA Expression by UniProt/SwissProt for HERPUD1 Gene

Q15011-HERP1_HUMAN
Tissue specificity: Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
genes like me logo Genes that share expression patterns with HERPUD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for HERPUD1 Gene

Orthologs for HERPUD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HERPUD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HERPUD1 35
  • 89.86 (n)
  • 89.43 (a)
HERPUD1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HERPUD1 35
  • 91.34 (n)
  • 91.34 (a)
HERPUD1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Herpud1 35
  • 86.79 (n)
  • 88.75 (a)
Herpud1 16
Herpud1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HERPUD1 35
  • 99.66 (n)
  • 100 (a)
HERPUD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Herpud1 35
  • 86.19 (n)
  • 87.21 (a)
oppossum
(Monodelphis domestica)
Mammalia HERPUD1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HERPUD1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves HERPUD1 35
  • 65.47 (n)
  • 58.68 (a)
HERPUD1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HERPUD1 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia herpud1 35
  • 58.73 (n)
  • 53.61 (a)
Str.2464 35
African clawed frog
(Xenopus laevis)
Amphibia herpud1-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.9626 35
herpud1 35
  • 54.86 (n)
  • 49.08 (a)
herpud1 36
  • 43 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6846 35
fruit fly
(Drosophila melanogaster)
Insecta Herp 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3209 36
  • 30 (a)
OneToMany
Species with no ortholog for HERPUD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HERPUD1 Gene

ENSEMBL:
Gene Tree for HERPUD1 (if available)
TreeFam:
Gene Tree for HERPUD1 (if available)

Paralogs for HERPUD1 Gene

Paralogs for HERPUD1 Gene

(1) SIMAP similar genes for HERPUD1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with HERPUD1: view

Variants for HERPUD1 Gene

Sequence variations from dbSNP and Humsavar for HERPUD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2217332 - 56,935,236(-) CTGGA(C/T)GCTGA reference, missense
rs3903056 -- 56,940,879(-) CCCAG(C/T)TCAAG intron-variant
rs9497 -- 56,943,662(+) TGGTA(A/C)GATTT utr-variant-3-prime
rs15104 -- 56,943,744(+) TTTAG(C/T)AGGAC utr-variant-3-prime
rs37023 -- 56,934,195(-) TAACA(A/T)ATAAT intron-variant

Variation tolerance for HERPUD1 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HERPUD1 Gene

Disorders for HERPUD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HERPUD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subclavian steal syndrome
  • subclavian artery stenosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HERPUD1

Genetic Association Database (GAD)
HERPUD1
Human Genome Epidemiology (HuGE) Navigator
HERPUD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HERPUD1
genes like me logo Genes that share disorders with HERPUD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HERPUD1 Gene

Publications for HERPUD1 Gene

  1. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. (PMID: 10922362) Kokame K. … Miyata T. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway. (PMID: 10708769) van Laar T. … Terleth C. (FEBS Lett. 2000) 2 3 23
  3. Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP. (PMID: 20054003) McLaughlin M. … Vandenbroeck K. (J. Biol. Chem. 2010) 3 23
  4. The endoplasmic reticulum stress-inducible protein, Herp, is a potential triggering antigen for anti-DNA response. (PMID: 20147634) Hirabayashi Y. … Harigae H. (J. Immunol. 2010) 3 23
  5. The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease. (PMID: 19447887) Chigurupati S. … Chan S.L. (J. Biol. Chem. 2009) 3 23

Products for HERPUD1 Gene

Sources for HERPUD1 Gene

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