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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HERPUD1 Gene

protein-coding   GIFtS: 62
GCID: GC16P056965

Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible,...

Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible,
Ubiquitin-Like Domain Member 11 2
     MMS-inducible2
HERP2 3 5     Mif12
Methyl Methanesulfonate (MMF)-Inducible Fragment Protein 12 3     SUP2
KIAA00253 5     Homocysteine-Inducible Endoplasmic Reticulum Stress-Inducible
Ubiquitin-Like Domain Member 1 Protein2
MIF13 5     Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like
Domain Member 1 Protein2

External Ids:    HGNC: 137441   Entrez Gene: 97092   Ensembl: ENSG000000511087   OMIM: 6080705   UniProtKB: Q150113   

Export aliases for HERPUD1 gene to outside databases

Previous GC identifers: GC16M047322 GC16P057017 GC16P056700 GC16P056741 GC16P055523 GC16P042835


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HERPUD1 Gene:
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This
response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the
increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR),
and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may
play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in
its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the
ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of
amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript
variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.
(provided by RefSeq, Jan 2013)

GeneCards Summary for HERPUD1 Gene: 
HERPUD1 (homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1) is a protein-coding gene. Diseases associated with HERPUD1 include inclusion body myositis, and myositis, and among its related super-pathways are PERK regulated gene expression and Activation of Chaperones by IRE1alpha. GO annotations related to this gene include molecular_function. An important paralog of this gene is HERPUD2.

UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011
Function: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated
degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could
enhance presenilin-mediated beta-amyloid protein 40 generation

Gene Wiki entry for HERPUD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HERPUD1 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHERPUD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HERPUD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HERPUD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

HERPUD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HERPUD1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056965:  view genomic region     (about GC identifiers)

Start:
56,965,748 bp from pter      End:
56,977,798 bp from pter
Size:
12,051 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011 (See protein sequence)
Recommended Name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein  
Size: 391 amino acids; 43720 Da
Subunit: Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Miscellaneous: Although the precise topology is not known, experimental data suggest that both the N- and
C-termini face the cytosol
1 PDB 3D structure from and Proteopedia for HERPUD1:
1WGD (3D)    
Secondary accessions: E9PGD1 O60644 Q6IAN8 Q96D92
Alternative splicing: 4 isoforms:  Q15011-1   Q15011-2   Q15011-3   Q15011-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HERPUD1: NX_Q15011

Explore proteomics data for HERPUD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15011

  • HERPUD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HERPUD1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001010989.1  NP_001259032.1  NP_055500.1  

    ENSEMBL proteins: 
     ENSP00000409555   ENSP00000456384   ENSP00000340931   ENSP00000300302   ENSP00000369118  
     ENSP00000457321   ENSP00000455094   ENSP00000457095   ENSP00000455841   ENSP00000457955  
    Reactome Protein details: Q15011
    Human Recombinant Protein Products for HERPUD1: 
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    Novus Biologicals HERPUD1 Proteins
    Novus Biologicals HERPUD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HERPUD1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    HERPUD1 for ontologies           About GeneDecksing



    HERPUD1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HERPUD1 

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    Cloud-Clone Corp. ELISAs for HERPUD1 
    Cloud-Clone Corp. CLIAs for HERPUD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry Q15011

    ProtoNet protein and cluster: Q15011

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011
    Similarity: Contains 1 ubiquitin-like domain


    HERPUD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HERP1_HUMAN, Q15011
    Function: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated
    degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could
    enhance presenilin-mediated beta-amyloid protein 40 generation
    Induction: Up-regulated by endoplasmic reticulum stress and CREB3

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    HERPUD1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HERPUD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HERPUD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HERPUD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HERPUD1 

    miRNA
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    hsa-mir-373 (MIRT002508)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HERPUD1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HERPUD1:
    hsa-miR-9* hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidHERPUD1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HERPUD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of Genes by ATF4
    Activation of Genes by ATF40.64
    PERK regulated gene expression0.64
    2Activation of Chaperone Genes by XBP1(S)
    Unfolded Protein Response0.76
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HERPUD1
        Diurnally regulated genes with circadian orthologs

    4        Reactome Pathways for HERPUD1
        PERK regulated gene expression
    Metabolism of proteins
    Activation of Genes by ATF4
    Unfolded Protein Response


    1         Kegg Pathway  (Kegg details for HERPUD1):
        Protein processing in endoplasmic reticulum


    HERPUD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HERPUD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for HERPUD1 (Q150112, 3 ENSP000003003024) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-8258131 I2D: score=2 STRING: ENSP00000352257
    USP7Q930092, 3, ENSP000003435354MINT-2867316 I2D: score=3 STRING: ENSP00000343535
    ARHGDIAP525652, 3, ENSP000002693214MINT-8258120 I2D: score=2 STRING: ENSP00000269321
    IMPA2O147323, ENSP000002691594I2D: score=3 STRING: ENSP00000269159
    PSEN1P497683, ENSP000003263664I2D: score=3 STRING: ENSP00000326366
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0006950response to stress ----
    GO:0006986response to unfolded protein IEP10708769
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--

    HERPUD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HERPUD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HERPUD1 (HERP1)

    2 Novoseek inferred chemical compound relationships for HERPUD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 55.4 4 10708769 (2), 10922362 (1)
    homocysteine 42.7 13 17020760 (6), 20164556 (2), 10922362 (1)

    Search CenterWatch for drugs/clinical trials and news about HERPUD1 / HERP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HERPUD1 gene (4 alternative transcripts): 
    NM_001010989.2  NM_001272103.1  NM_014685.3  NM_001010990.1  

    Unigene Cluster for HERPUD1:

    Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
    Hs.146393  [show with all ESTs]
    Unigene Representative Sequence: AF217990
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000439977(uc002eke.1 uc002ekf.1 uc002ekg.1 uc010cco.1 uc010ccp.1)
    ENST00000562914 ENST00000568676 ENST00000569569(uc010vhj.1) ENST00000565966
    ENST00000344114 ENST00000300302 ENST00000570273 ENST00000379792 ENST00000569429
    ENST00000563343 ENST00000566550 ENST00000563781 ENST00000568358 ENST00000564678(uc002ekh.1)
    ENST00000563911 ENST00000567944 ENST00000568651

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HERPUD1:
    hsa-miR-9* hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidHERPUD1 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of HERPUD1 
                         Customized lentivirus expression plasmids for stable overexpression of HERPUD1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HERPUD1
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    Additional mRNA sequence: 

    AB034989.1 AF055001.1 AF055003.1 AF217990.1 AK223233.1 AK291565.1 AK292088.1 AK302167.1 
    AK304800.1 BC000086.1 BC008320.1 BC009739.1 BC032673.1 CR457116.1 D14695.1 DQ837586.1 

    24/28 DOTS entries (see all 28):

    DT.119762  DT.92064876  DT.91913405  DT.100690353  DT.97867781  DT.119765  DT.120683566  DT.120683560 
    DT.91913364  DT.95131850  DT.100044140  DT.120683520  DT.120683563  DT.40123628  DT.86994662  DT.95351209 
    DT.100736730  DT.100832578  DT.120683524  DT.120683527  DT.120683536  DT.120683565  DT.75169426  DT.91913615 

    24/684 AceView cDNA sequences (see all 684):

    AI445332 NM_014685 BQ937531 BG757055 BM673314 BM707911 AI474455 CA435725 
    BQ683531 AW615745 BX477534 BQ775715 BP352220 BQ943111 CB216553 CA447062 
    CB306441 CA417314 BF439995 AI097015 BM699958 BC008320 BE046206 BM988821 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HERPUD1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                    -                 -     -     -     -                 -                                                               
    SP2:                    -                 -     -     -     -                 -                                                               
    SP3:                    -                 -     -     -     -                 -     -     -     -     -     -                                 
    SP4:                    -           -     -     -     -     -                 -                                                               
    SP5:                                                                          -                                                               


    ECgene alternative splicing isoforms for HERPUD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HERPUD1 expression in normal human tissues (normalized intensities)      HERPUD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAGCAGG
    HERPUD1 Expression
    About this image


    HERPUD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Skeletal Muscle (Muscoskeletal System)
             Human Skeletal Muscle Cells (HSkMC)   

    See HERPUD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HERPUD1

    SOURCE GeneReport for Unigene cluster: Hs.146393

    UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011
    Tissue specificity: Widely expressed; in the brain, expression seems to be restricted to neurons and vascular
    smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer
    disease

        SABiosciences Expression via Pathway-Focused PCR Arrays including HERPUD1: 
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              TGFB Signaling Targets in human mouse rat
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              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERPUD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HERPUD1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Herpud11 , 5 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 less1, 5 86.79(n)1
    88.75(a)1
      8 (46.46 cM)5
    642091  NM_022331.11  NP_071726.11 
     943864385 
    chicken
    (Gallus gallus)
    Aves HERPUD11 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 less 65.04(n)
    58.15(a)
      415644  XM_414010.3  XP_414010.3 
    lizard
    (Anolis carolinensis)
    Reptilia HERPUD16
    homocysteine-inducible, endoplasmic reticulum stre...
    46(a)
    1 ↔ 1
    GL344281.1(21-7939)
    African clawed frog
    (Xenopus laevis)
    Amphibia herpud1-A-prov2 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 less 75.59(n)    BC046268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.96262 Transcribed sequence with weak similarity to protein spQ15011 (H.sapiens) HERP_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1) less 75.4(n)    CA470363.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Herp6
    Homocysteine-induced endoplasmic reticulum protein...
    22(a)
    1 → many
    2L(7796308-7799846)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3536
    Protein TAG-353
    19(a)
    1 → many
    I(10401067-10402774)


    ENSEMBL Gene Tree for HERPUD1 (if available)
    TreeFam Gene Tree for HERPUD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HERPUD1 gene
    HERPUD22  
    1 SIMAP similar gene for HERPUD1 using alignment to 8 protein entries:     HERP1_HUMAN (see all proteins):
    HERPUD2

    HERPUD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/352 SNPs in HERPUD1 are shown (see all 352)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896441971,2
    --56963785(+) GAGGCA/GAGGAG 2 -- us2k10--------
    rs1826217531,2
    --56963995(+) TGGGCA/GACAGA 2 -- us2k10--------
    rs1996985391,2
    C--56964141(+) GTTGT-/TG    
       T
    /TTG
    GTTTT
    8 -- cds10--------
    rs1425544461,2
    --56964155(+) TTGTTA/GTTGTG 4 -- us2k10--------
    rs1869956171,2
    --56964203(+) GTTGCC/TCAGGC 4 -- us2k10--------
    rs1931930341,2
    --56964351(+) AGAGAC/GGGGGT 4 -- us2k10--------
    rs99250541,2
    C--56964407(+) ccaccC/Tgcctc 4 -- us2k15Minor allele frequency- T:0.11NA WA CSA 9
    rs99321641,2
    C,F--56964445(+) cgtgaG/Tccacc 4 -- us2k16Minor allele frequency- T:0.20NA WA CSA 128
    rs1834534201,2
    --56964463(+) GCCTCA/TAACAT 4 -- us2k10--------
    rs1406779751,2
    --56964595(+) AAGCAA/GTTGAT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for HERPUD1 (56965748 - 56977798 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HERPUD1: --
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for HERPUD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608070    OMIM disorders: --

    9 diseases for HERPUD1:    About MalaCards
    inclusion body myositis    myositis    hyperhomocysteinemia    lupus nephritis
    nephritis    parkinson's disease    myocardial infarction    alzheimer's disease
    neuronitis


    HERPUD1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HERPUD1
    Human Genome Epidemiology (HuGE) Navigator: HERPUD1 (2 documents)

    Export disorders for HERPUD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HERPUD1 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with HERPUD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. (PubMed id 10922362)1, 2, 3, 9 Kokame K.... Miyata T. (2000)
    2. The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway. (PubMed id 10708769)1, 2, 3, 9 van Laar T....Terleth C. (2000)
    3. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. (PubMed id 11799129)1, 2, 9 Sai X.... Komano H. (2002)
    4. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. (PubMed id 11112790)1, 2, 9 Kokame K.... Miyata T. (2001)
    5. The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. (PubMed id 16289116)1, 2, 9 Schulze A.... Seeger M. (2005)
    6. A genome-wide association study of the metabolic synd rome in Indian Asian men. (PubMed id 20694148)1, 4 Zabaneh D. and Balding D.J. (2010)
    7. Longitudinal genome-wide association of cardiovascula r disease risk factors in the bogalusa heart study. (PubMed id 20838585)1, 4 Smith E.N....Murray S.S. (2010)
    8. Polymorphism in the CETP gene region, HDL cholesterol , and risk of future myocardial infarction: Genomewide analysis among 18 245 in itially healthy women from the Women's Genome Health Study. (PubMed id 20031564)1, 4 Ridker P.M....Chasman D.I. (2009)
    9. Ubxd1 is a novel co-factor of the human p97 ATPase. (PubMed id 18656546)1, 2 Madsen L....Hartmann-Petersen R. (2008)
    10. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. (PubMed id 16940180)1, 2 Liang G....Lu R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9709 HGNC: 13744 AceView: HERPUD1 Ensembl:ENSG00000051108 euGenes: HUgn9709
    ECgene: HERPUD1 Kegg: 9709 H-InvDB: HERPUD1

    (According to HUGE)
    About This Section
    HUGE: KIAA0025

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HERPUD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HERPUD1 gene:
    Search GeneIP for patents involving HERPUD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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