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HERPUD1 Gene

protein-coding   GIFtS: 61
GCID: GC16P056965

Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible,...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible,
Ubiquitin-Like Domain Member 11 2
     MMS-inducible2
HERP2 3 5     Mif12
Methyl Methanesulfonate (MMF)-Inducible Fragment Protein 12 3     SUP2
KIAA00253 5     Homocysteine-Inducible Endoplasmic Reticulum Stress-Inducible
Ubiquitin-Like Domain Member 1 Protein2
MIF13 5     Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like
Domain Member 1 Protein2

External Ids:    HGNC: 137441   Entrez Gene: 97092   Ensembl: ENSG000000511087   OMIM: 6080705   UniProtKB: Q150113   

Export aliases for HERPUD1 gene to outside databases

Previous GC identifers: GC16M047322 GC16P057017 GC16P056700 GC16P056741 GC16P055523 GC16P042835


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HERPUD1 Gene:
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This
response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the
increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR),
and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may
play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in
its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the
ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of
amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript
variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.
(provided by RefSeq, Jan 2013)

GeneCards Summary for HERPUD1 Gene:
HERPUD1 (homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1) is a protein-coding gene. Diseases associated with HERPUD1 include inclusion body myositis, and myositis. An important paralog of this gene is HERPUD2.

UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011
Function: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated
degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could
enhance presenilin-mediated beta-amyloid protein 40 generation

Gene Wiki entry for HERPUD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HERPUD1 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHERPUD1 promoter sequence
   Search Chromatin IP Primers for HERPUD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HERPUD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

HERPUD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HERPUD1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056965:  view genomic region     (about GC identifiers)

Start:
56,965,748 bp from pter      End:
56,977,798 bp from pter
Size:
12,051 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011 (See protein sequence)
Recommended Name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein  
Size: 391 amino acids; 43720 Da
Subunit: Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6
Miscellaneous: Although the precise topology is not known, experimental data suggest that both the N- and
C-termini face the cytosol
1 PDB 3D structure from and Proteopedia for HERPUD1:
1WGD (3D)    
Secondary accessions: E9PGD1 O60644 Q6IAN8 Q96D92
Alternative splicing: 4 isoforms:  Q15011-1   Q15011-2   Q15011-3   Q15011-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HERPUD1: NX_Q15011

Explore proteomics data for HERPUD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HERPUD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001010989.1  NP_001259032.1  NP_055500.1  

    ENSEMBL proteins: 
     ENSP00000409555   ENSP00000456384   ENSP00000340931   ENSP00000300302   ENSP00000369118  
     ENSP00000457321   ENSP00000455094   ENSP00000457095   ENSP00000455841   ENSP00000457955  
    Reactome Protein details: Q15011

    HERPUD1 Human Recombinant Protein Products:

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    Novus Biologicals HERPUD1 Proteins
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    Cloud-Clone Corp. Proteins for HERPUD1

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    Abcam antibodies for HERPUD1
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    ThermoFisher Antibody for HERPUD1
    LSBio Antibodies in human, mouse, rat for HERPUD1

    HERPUD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HERPUD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HERPUD1
    Cloud-Clone Corp. CLIAs for HERPUD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry Q15011

    ProtoNet protein and cluster: Q15011

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011
    Similarity: Contains 1 ubiquitin-like domain


    HERPUD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HERP1_HUMAN, Q15011
    Function: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated
    degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could
    enhance presenilin-mediated beta-amyloid protein 40 generation
    Induction: Up-regulated by endoplasmic reticulum stress and CREB3

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    HERPUD1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HERPUD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HERPUD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HERPUD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HERPUD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HERPUD1:
    hsa-mir-26b-5p (MIRT029926), hsa-mir-615-3p (MIRT039770), hsa-mir-93-5p (MIRT048869), hsa-mir-373-3p (MIRT002508), hsa-mir-375 (MIRT019938), hsa-mir-335-5p (MIRT018664)

    Block miRNA regulation of human, mouse, rat HERPUD1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HERPUD1:
    hsa-miR-9* hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidHERPUD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HERPUD1
    Predesigned siRNA for gene silencing in human, mouse, rat HERPUD1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for HERPUD1 (see all 17)
    OriGene ORF clones in mouse, rat for HERPUD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HERPUD1 (NM_014685)
    Sino Biological Human cDNA Clone for HERPUD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HERPUD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERPUD1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HERPUD1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERPUD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HERP1_HUMAN, Q15011: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    HERPUD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HERPUD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    2Unfolded Protein Response
    Unfolded Protein Response0.61
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HERPUD1
        Diurnally regulated genes with circadian orthologs


    1 Reactome Pathway for HERPUD1
        ATF4 activates genes


    1 Kegg Pathway  (Kegg details for HERPUD1):
        Protein processing in endoplasmic reticulum


    HERPUD1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HERPUD1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HERPUD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HERPUD1 (Q150112, 3 ENSP000003003024) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-8258131 I2D: score=2 STRING: ENSP00000352257
    USP7Q930092, 3, ENSP000003435354MINT-2867316 I2D: score=3 STRING: ENSP00000343535
    ARHGDIAP525652, 3, ENSP000002693214MINT-8258120 I2D: score=2 STRING: ENSP00000269321
    IMPA2O147323, ENSP000002691594I2D: score=3 STRING: ENSP00000269159
    PSEN1P497683, ENSP000003263664I2D: score=3 STRING: ENSP00000326366
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0006986response to unfolded protein IEP10708769
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--

    HERPUD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HERPUD1 (HERP1)

    2 Novoseek inferred chemical compound relationships for HERPUD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 55.4 4 10708769 (2), 10922362 (1)
    homocysteine 42.7 13 17020760 (6), 20164556 (2), 10922362 (1)



    HERPUD1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HERPUD1 gene (4 alternative transcripts): 
    NM_001010989.2  NM_001272103.1  NM_014685.3  NM_001010990.1  

    Unigene Cluster for HERPUD1:

    Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
    Hs.146393  [show with all ESTs]
    Unigene Representative Sequence: AF217990
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000439977(uc002eke.1 uc002ekf.1 uc002ekg.1 uc010cco.1 uc010ccp.1)
    ENST00000562914 ENST00000568676 ENST00000569569(uc010vhj.1) ENST00000565966
    ENST00000344114 ENST00000300302 ENST00000570273 ENST00000379792 ENST00000569429
    ENST00000563343 ENST00000566550 ENST00000563781 ENST00000568358 ENST00000564678(uc002ekh.1)
    ENST00000563911 ENST00000567944 ENST00000568651

    miRNA
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    Block miRNA regulation of human, mouse, rat HERPUD1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HERPUD1:
    hsa-miR-9* hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidHERPUD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HERPUD1
    Predesigned siRNA for gene silencing in human, mouse, rat HERPUD1
    Clone
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    OriGene clones in human, mouse for HERPUD1 (see all 17)
    OriGene ORF clones in mouse, rat for HERPUD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HERPUD1 (NM_014685)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HERPUD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERPUD1
    Primer
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    OriGene qPCR primer pairs and template standards for HERPUD1
    OriGene qSTAR qPCR primer pairs in human, mouse for HERPUD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HERPUD1
      QuantiTect SYBR Green Assays in human, mouse, rat HERPUD1
      QuantiFast Probe-based Assays in human, mouse, rat HERPUD1

    Additional mRNA sequence: 

    AB034989.1 AF055001.1 AF055003.1 AF217990.1 AK223233.1 AK291565.1 AK292088.1 AK302167.1 
    AK304800.1 BC000086.1 BC008320.1 BC009739.1 BC032673.1 CR457116.1 D14695.1 DQ837586.1 

    Selected DOTS entries (see all 28):

    DT.119762  DT.92064876  DT.91913405  DT.100690353  DT.97867781  DT.119765  DT.120683566  DT.120683560 
    DT.91913364  DT.95131850  DT.100044140  DT.120683520  DT.120683563  DT.40123628  DT.86994662  DT.95351209 
    DT.100736730  DT.100832578  DT.120683524  DT.120683527  DT.120683536  DT.120683565  DT.75169426  DT.91913615 

    Selected AceView cDNA sequences (see all 684):

    CA446941 AW194163 BG757055 BQ020563 BQ684466 BP352220 AI091768 AW591472 
    BQ233399 BM707911 AW135359 BC009739 AI312110 BC000086 AA988993 BQ939568 
    AI472208 BU786104 BM817980 BU726849 BM795541 BQ229599 AA485473 BI915919 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HERPUD1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                    -                 -     -     -     -                 -                                                               
    SP2:                    -                 -     -     -     -                 -                                                               
    SP3:                    -                 -     -     -     -                 -     -     -     -     -     -                                 
    SP4:                    -           -     -     -     -     -                 -                                                               
    SP5:                                                                          -                                                               


    ECgene alternative splicing isoforms for HERPUD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HERPUD1 expression in normal human tissues (normalized intensities)      HERPUD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAGCAGG
    HERPUD1 Expression
    About this image


    HERPUD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Periportal Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    HERPUD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HERPUD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146393

    UniProtKB/Swiss-Prot: HERP1_HUMAN, Q15011
    Tissue specificity: Widely expressed; in the brain, expression seems to be restricted to neurons and vascular
    smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer
    disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HERPUD1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HERPUD1
    OriGene qSTAR qPCR primer pairs in human, mouse for HERPUD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HERPUD1
    QuantiTect SYBR Green Assays in human, mouse, rat HERPUD1
    QuantiFast Probe-based Assays in human, mouse, rat HERPUD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERPUD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HERPUD1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Herpud11 , 5 homocysteine-inducible, endoplasmic reticulum stress-inducible, more1, 5 86.79(n)1
    88.75(a)1
      8 (46.46 cM)5
    642091  NM_022331.11  NP_071726.11 
     943864385 
    chicken
    (Gallus gallus)
    Aves HERPUD11 homocysteine-inducible, endoplasmic reticulum stress-inducible, more 65.47(n)
    58.68(a)
      415644  XM_414010.4  XP_414010.3 
    lizard
    (Anolis carolinensis)
    Reptilia HERPUD16
    homocysteine-inducible, endoplasmic reticulum stre...
    46(a)
    1 ↔ 1
    GL344281.1(21-7939)
    African clawed frog
    (Xenopus laevis)
    Amphibia herpud1-A-prov2 homocysteine-inducible, endoplasmic reticulum stress-inducible, more 75.59(n)    BC046268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.96262 Transcribed sequence with weak similarity to protein more 75.4(n)    CA470363.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Herp6
    Homocysteine-induced endoplasmic reticulum protein...
    23(a)
    1 → many
    2L(7796308-7799846)


    ENSEMBL Gene Tree for HERPUD1 (if available)
    TreeFam Gene Tree for HERPUD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HERPUD1 gene
    HERPUD22  
    1 SIMAP similar gene for HERPUD1 using alignment to 8 protein entries:     HERP1_HUMAN (see all proteins):
    HERPUD2

    HERPUD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HERPUD1 (see all 352)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896441971,2
    --56963785(+) GAGGCA/GAGGAG 2 -- us2k10--------
    rs1826217531,2
    --56963995(+) TGGGCA/GACAGA 2 -- us2k10--------
    rs1996985391,2
    C--56964141(+) GTTGT-/TG    
       T
    /TTG
    GTTTT
    8 -- cds10--------
    rs1425544461,2
    --56964155(+) TTGTTA/GTTGTG 4 -- us2k10--------
    rs1869956171,2
    --56964203(+) GTTGCC/TCAGGC 4 -- us2k10--------
    rs1931930341,2
    --56964351(+) AGAGAC/GGGGGT 4 -- us2k10--------
    rs99250541,2
    C--56964407(+) ccaccC/Tgcctc 4 -- us2k15Minor allele frequency- T:0.11NA WA CSA 9
    rs99321641,2
    C,F--56964445(+) cgtgaG/Tccacc 4 -- us2k16Minor allele frequency- T:0.20NA WA CSA 128
    rs1834534201,2
    --56964463(+) GCCTCA/TAACAT 4 -- us2k10--------
    rs1406779751,2
    --56964595(+) AAGCAA/GTTGAT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for HERPUD1 (56965748 - 56977798 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HERPUD1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HERPUD1
    DNA2.0 Custom Variant and Variant Library Synthesis for HERPUD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608070    OMIM disorders: --

    16 diseases for HERPUD1:    About MalaCards
    inclusion body myositis    myositis    hyperhomocysteinemia    cardiovascular disease risk factor
    lupus nephritis    nephritis    age related macular degeneration    coronary artery disease
    coronary heart disease    parkinson's disease    myocardial infarction    meningioma
    insulin resistance    ataxia    alzheimer's disease    neuronitis


    HERPUD1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HERPUD1
    Human Genome Epidemiology (HuGE) Navigator: HERPUD1 (2 documents)

    Export disorders for HERPUD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HERPUD1 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with HERPUD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. (PubMed id 10922362)1, 2, 3, 9 Kokame K.... Miyata T. (J. Biol. Chem. 2000)
    2. The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway. (PubMed id 10708769)1, 2, 3, 9 van Laar T....Terleth C. (FEBS Lett. 2000)
    3. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. (PubMed id 11799129)1, 2, 9 Sai X.... Komano H. (J. Biol. Chem. 2002)
    4. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. (PubMed id 11112790)1, 2, 9 Kokame K.... Miyata T. (J. Biol. Chem. 2001)
    5. The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. (PubMed id 16289116)1, 2, 9 Schulze A.... Seeger M. (J. Mol. Biol. 2005)
    6. A genome-wide association study of the metabolic syndrome in Indian Asian men. (PubMed id 20694148)1, 4 Zabaneh D. and Balding D.J. (PLoS ONE 2010)
    7. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (PubMed id 20838585)1, 4 Smith E.N....Murray S.S. (PLoS Genet. 2010)
    8. Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study. (PubMed id 20031564)1, 4 Ridker P.M....Chasman D.I. (Circ Cardiovasc Genet 2009)
    9. Ubxd1 is a novel co-factor of the human p97 ATPase. (PubMed id 18656546)1, 2 Madsen L....Hartmann-Petersen R. (Int. J. Biochem. Cell Biol. 2008)
    10. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. (PubMed id 16940180)1, 2 Liang G.... Lu R. (Mol. Cell. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9709 HGNC: 13744 AceView: HERPUD1 Ensembl:ENSG00000051108 euGenes: HUgn9709
    ECgene: HERPUD1 Kegg: 9709 H-InvDB: HERPUD1

    (According to HUGE)
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    HUGE: KIAA0025

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HERPUD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HERPUD1 gene:
    Search GeneIP for patents involving HERPUD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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