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Aliases for HERPUD1 Gene

Aliases for HERPUD1 Gene

  • Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1 2 3 5
  • Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 1 2 3
  • Methyl Methanesulfonate (MMF)-Inducible Fragment Protein 1 3 4
  • Mif1 3 4
  • HERP 3 4
  • Homocysteine-Inducible Endoplasmic Reticulum Stress-Inducible Ubiquitin-Like Domain Member 1 Protein 3
  • Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 Protein 3
  • MMS-Inducible 3
  • KIAA0025 4
  • SUP 3

External Ids for HERPUD1 Gene

Previous GeneCards Identifiers for HERPUD1 Gene

  • GC16M047322
  • GC16P057017
  • GC16P056700
  • GC16P056741
  • GC16P055523
  • GC16P042835

Summaries for HERPUD1 Gene

Entrez Gene Summary for HERPUD1 Gene

  • The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]

GeneCards Summary for HERPUD1 Gene

HERPUD1 (Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and PERK regulates gene expression. GO annotations related to this gene include ion channel binding. An important paralog of this gene is HERPUD2.

UniProtKB/Swiss-Prot for HERPUD1 Gene

  • Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).

Gene Wiki entry for HERPUD1 Gene

Additional gene information for HERPUD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERPUD1 Gene

Genomics for HERPUD1 Gene

Regulatory Elements for HERPUD1 Gene

Enhancers for HERPUD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H056908 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.6 -20.4 -20395 5 HDGF FOXA2 TBL1XR1 RB1 BMI1 BATF EGR1 SCRT2 ATF7 ETV6 HERPUD1 MIR138-2 MT1G MT1H ENSG00000261270 NLRC5 RPS24P17
GH16H056914 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -14.5 -14469 5 HDGF PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YBX1 ZNF121 SLC30A9 HERPUD1 MIR138-2 ENSG00000261270 MT1X NLRC5 RPS24P17
GH16H056964 1.3 Ensembl ENCODE 11.4 +33.6 33630 2 ARNT ARID4B DMAP1 SLC30A9 ZNF207 ZNF143 FOS DEK SP5 ZC3H11A RSPRY1 NLRC5 HERPUD1 FAM192A NUDT21 POLR2C GC16M056955 GC16M056973
GH16H056930 1.4 ENCODE dbSUPER 9.7 +3.8 3754 10 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 RSPRY1 NUDT21 POLR2C NUP93 CETP SLC12A3 LOC105371286 ENSG00000261270 CCDC102A NLRC5
GH16H056869 1.1 Ensembl ENCODE 11.7 -61.8 -61823 0 ELF3 PKNOX1 ATF1 ARID4B RAD21 RARA ZNF143 ATF7 RUNX3 CREM HERPUD1 MT1G MT1H SLC12A3 MIR6863
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HERPUD1 on UCSC Golden Path with GeneCards custom track

Promoters for HERPUD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086344 1435 3201 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41

Transcription factor binding sites by QIAGEN in the HERPUD1 gene promoter:

Genomic Location for HERPUD1 Gene

Chromosome:
16
Start:
56,931,765 bp from pter
End:
56,944,863 bp from pter
Size:
13,099 bases
Orientation:
Plus strand

Genomic View for HERPUD1 Gene

Genes around HERPUD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HERPUD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HERPUD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERPUD1 Gene

Proteins for HERPUD1 Gene

  • Protein details for HERPUD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15011-HERP1_HUMAN
    Recommended name:
    Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Protein Accession:
    Q15011
    Secondary Accessions:
    • E9PGD1
    • O60644
    • Q6IAN8
    • Q96D92

    Protein attributes for HERPUD1 Gene

    Size:
    391 amino acids
    Molecular mass:
    43720 Da
    Quaternary structure:
    • Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6. Interacts with UBQLN1, UBQLN2 and UBQLN4.
    Miscellaneous:
    • Although the precise topology is not known, experimental data suggest that both the N- and C-termini face the cytosol.

    Three dimensional structures from OCA and Proteopedia for HERPUD1 Gene

    Alternative splice isoforms for HERPUD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HERPUD1 Gene

Post-translational modifications for HERPUD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HERPUD1 (HERPUD1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for HERPUD1

No data available for DME Specific Peptides for HERPUD1 Gene

Domains & Families for HERPUD1 Gene

Gene Families for HERPUD1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for HERPUD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HERPUD1: view

No data available for UniProtKB/Swiss-Prot for HERPUD1 Gene

Function for HERPUD1 Gene

Molecular function for HERPUD1 Gene

UniProtKB/Swiss-Prot Function:
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).
UniProtKB/Swiss-Prot Induction:
Up-regulated by endoplasmic reticulum stress and CREB3.

Phenotypes From GWAS Catalog for HERPUD1 Gene

Gene Ontology (GO) - Molecular Function for HERPUD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 18307982
GO:0044325 ion channel binding IPI 22045699
genes like me logo Genes that share ontologies with HERPUD1: view
genes like me logo Genes that share phenotypes with HERPUD1: view

Animal Models for HERPUD1 Gene

MGI Knock Outs for HERPUD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HERPUD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HERPUD1 Gene

Localization for HERPUD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERPUD1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HERPUD1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
plasma membrane 2
nucleus 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HERPUD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 15102845
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0034704 colocalizes_with calcium channel complex IPI 22045699
genes like me logo Genes that share ontologies with HERPUD1: view

Pathways & Interactions for HERPUD1 Gene

genes like me logo Genes that share pathways with HERPUD1: view

Pathways by source for HERPUD1 Gene

SIGNOR curated interactions for HERPUD1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HERPUD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0006986 response to unfolded protein IEP 10708769
GO:0030968 endoplasmic reticulum unfolded protein response IEA --
GO:0030970 retrograde protein transport, ER to cytosol IMP 25660456
genes like me logo Genes that share ontologies with HERPUD1: view

Drugs & Compounds for HERPUD1 Gene

(1) Drugs for HERPUD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for HERPUD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HERPUD1: view

Transcripts for HERPUD1 Gene

Unigene Clusters for HERPUD1 Gene

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HERPUD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HERPUD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: - - - -
SP8: -
SP9: -
SP10:
SP11:

Relevant External Links for HERPUD1 Gene

GeneLoc Exon Structure for
HERPUD1
ECgene alternative splicing isoforms for
HERPUD1

Expression for HERPUD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HERPUD1 Gene

Protein differential expression in normal tissues from HIPED for HERPUD1 Gene

This gene is overexpressed in Bone (46.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HERPUD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of HERPUD1 Gene:

HERPUD1

SOURCE GeneReport for Unigene cluster for HERPUD1 Gene:

Hs.146393

mRNA Expression by UniProt/SwissProt for HERPUD1 Gene:

Q15011-HERP1_HUMAN
Tissue specificity: Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.

Evidence on tissue expression from TISSUES for HERPUD1 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Skin(4.6)
  • Bone marrow(4.4)
  • Heart(4.4)
  • Liver(4.4)
  • Lung(3.9)
  • Intestine(3.3)
  • Kidney(3)
  • Spleen(2.3)
  • Stomach(2.3)
  • Pancreas(2.2)
  • Thyroid gland(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with HERPUD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HERPUD1 Gene

Orthologs for HERPUD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HERPUD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HERPUD1 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia HERPUD1 33 34
  • 91.34 (n)
cow
(Bos Taurus)
Mammalia HERPUD1 33 34
  • 89.86 (n)
mouse
(Mus musculus)
Mammalia Herpud1 33 16 34
  • 86.79 (n)
rat
(Rattus norvegicus)
Mammalia Herpud1 33
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia HERPUD1 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HERPUD1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves HERPUD1 33 34
  • 65.47 (n)
lizard
(Anolis carolinensis)
Reptilia HERPUD1 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia herpud1 33
  • 58.73 (n)
Str.2464 33
African clawed frog
(Xenopus laevis)
Amphibia herpud1-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii herpud1 33 34
  • 54.86 (n)
Dr.9626 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6846 33
fruit fly
(Drosophila melanogaster)
Insecta Herp 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3209 34
  • 30 (a)
OneToMany
Species where no ortholog for HERPUD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HERPUD1 Gene

ENSEMBL:
Gene Tree for HERPUD1 (if available)
TreeFam:
Gene Tree for HERPUD1 (if available)

Paralogs for HERPUD1 Gene

Paralogs for HERPUD1 Gene

(1) SIMAP similar genes for HERPUD1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with HERPUD1: view

Variants for HERPUD1 Gene

Sequence variations from dbSNP and Humsavar for HERPUD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000020476 -- 56,930,255(+) TTTTG(G/T)TTTTT upstream-variant-2KB
rs1000239191 -- 56,930,449(+) TTTCA(C/T)CATGT upstream-variant-2KB
rs1000552613 -- 56,936,501(+) TCTAT(A/G)TATTG intron-variant
rs1000791053 -- 56,941,550(+) AAACT(A/G)AAAGA intron-variant
rs1001276154 -- 56,934,580(+) TCTGA(G/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HERPUD1 Gene

Variant ID Type Subtype PubMed ID
nsv1059098 CNV gain 25217958

Variation tolerance for HERPUD1 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HERPUD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HERPUD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HERPUD1 Gene

Disorders for HERPUD1 Gene

Relevant External Links for HERPUD1

Genetic Association Database (GAD)
HERPUD1
Human Genome Epidemiology (HuGE) Navigator
HERPUD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HERPUD1

No disorders were found for HERPUD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HERPUD1 Gene

Publications for HERPUD1 Gene

  1. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. (PMID: 10922362) Kokame K … Miyata T (The Journal of biological chemistry 2000) 2 3 4 22 60
  2. The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway. (PMID: 10708769) van Laar T … Terleth C (FEBS letters 2000) 2 3 4 22 60
  3. The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. (PMID: 16289116) Schulze A … Seeger M (Journal of molecular biology 2005) 3 4 22 60
  4. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. (PMID: 11799129) Sai X … Komano H (The Journal of biological chemistry 2002) 3 4 22 60
  5. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. (PMID: 11112790) Kokame K … Miyata T (The Journal of biological chemistry 2001) 3 4 22 60

Products for HERPUD1 Gene

Sources for HERPUD1 Gene

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