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Aliases for HERC6 Gene

Aliases for HERC6 Gene

  • HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 6 2 3
  • HECT Domain And RCC1-Like Domain-Containing Protein 6 4
  • Hect Domain And RLD 6 2
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for HERC6 Gene

Previous GeneCards Identifiers for HERC6 Gene

  • GC04U900413
  • GC04P089603
  • GC04P089518
  • GC04P089299
  • GC04P085051

Summaries for HERC6 Gene

Entrez Gene Summary for HERC6 Gene

  • HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HERC6 Gene

HERC6 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 6) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is HERC5.

UniProtKB/Swiss-Prot for HERC6 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERC6 Gene

Genomics for HERC6 Gene

Regulatory Elements for HERC6 Gene

Genomic Location for HERC6 Gene

Chromosome:
4
Start:
88,378,535 bp from pter
End:
88,443,111 bp from pter
Size:
64,577 bases
Orientation:
Plus strand

Genomic View for HERC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HERC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERC6 Gene

Proteins for HERC6 Gene

  • Protein details for HERC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVU3-HERC6_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase HERC6
    Protein Accession:
    Q8IVU3
    Secondary Accessions:
    • B4DIY5
    • Q5GC90
    • Q5GRH3
    • Q5HYM6
    • Q5JPB6
    • Q6PIF4
    • Q8NAN3
    • Q9NWS4

    Protein attributes for HERC6 Gene

    Size:
    1022 amino acids
    Molecular mass:
    115126 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91303.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03879.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI46056.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI46151.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HERC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HERC6 Gene

Proteomics data for HERC6 Gene at MOPED

Selected DME Specific Peptides for HERC6 Gene

Post-translational modifications for HERC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HERC6 Gene

Domains & Families for HERC6 Gene

Protein Domains for HERC6 Gene

Suggested Antigen Peptide Sequences for HERC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVU3

UniProtKB/Swiss-Prot:

HERC6_HUMAN :
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 5 RCC1 repeats.
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Similarity:
  • Contains 5 RCC1 repeats.
genes like me logo Genes that share domains with HERC6: view

No data available for Gene Families for HERC6 Gene

Function for HERC6 Gene

Molecular function for HERC6 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for HERC6 Gene

Gene Ontology (GO) - Molecular Function for HERC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0016874 ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with HERC6: view
genes like me logo Genes that share phenotypes with HERC6: view

Animal Model Products

CRISPR Products

miRNA for HERC6 Gene

miRTarBase miRNAs that target HERC6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HERC6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for HERC6 Gene

Localization for HERC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERC6 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HERC6 Gene COMPARTMENTS Subcellular localization image for HERC6 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for HERC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with HERC6: view

Pathways & Interactions for HERC6 Gene

SuperPathways for HERC6 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat
    • Ubiquitin Ligases in human,mouse,rat

UniProtKB/Swiss-Prot Q8IVU3-HERC6_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for HERC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0016567 protein ubiquitination IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process --
genes like me logo Genes that share ontologies with HERC6: view

No data available for Pathways by source and SIGNOR curated interactions for HERC6 Gene

Drugs & Compounds for HERC6 Gene

No Compound Related Data Available

Transcripts for HERC6 Gene

Unigene Clusters for HERC6 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HERC6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HERC6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - -
SP7:
SP8:

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for HERC6 Gene

GeneLoc Exon Structure for
HERC6
ECgene alternative splicing isoforms for
HERC6

Expression for HERC6 Gene

mRNA expression in normal human tissues for HERC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HERC6 Gene

This gene is overexpressed in Fetal heart (17.8), Heart (12.4), Liver (11.6), Plasma (10.3), Monocytes (8.7), and Platelet (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HERC6 Gene



SOURCE GeneReport for Unigene cluster for HERC6 Gene Hs.529317

mRNA Expression by UniProt/SwissProt for HERC6 Gene

Q8IVU3-HERC6_HUMAN
Tissue specificity: Detected in brain, heart, placenta and testis.
genes like me logo Genes that share expression patterns with HERC6: view

Protein tissue co-expression partners for HERC6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HERC6 Gene

Orthologs for HERC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HERC6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HERC6 35
  • 82.96 (n)
  • 74.19 (a)
HERC6 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HERC6 35
  • 82.94 (n)
  • 73.91 (a)
HERC6 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Herc6 35
  • 77.25 (n)
  • 68.04 (a)
Herc6 16
Herc6 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HERC6 35
  • 98.73 (n)
  • 97.45 (a)
HERC6 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Herc6 35
  • 76.38 (n)
  • 65.33 (a)
oppossum
(Monodelphis domestica)
Mammalia HERC6 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HERC6 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia herc6 35
  • 56.01 (n)
  • 43.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6678 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K11D2.1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for HERC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HERC6 Gene

ENSEMBL:
Gene Tree for HERC6 (if available)
TreeFam:
Gene Tree for HERC6 (if available)

Paralogs for HERC6 Gene

Paralogs for HERC6 Gene

(9) SIMAP similar genes for HERC6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HERC6: view

Variants for HERC6 Gene

Sequence variations from dbSNP and Humsavar for HERC6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_051725 -
VAR_051726 -
VAR_051727 -
VAR_051728 -

Structural Variations from Database of Genomic Variants (DGV) for HERC6 Gene

Variant ID Type Subtype PubMed ID
nsv879531 CNV Loss 21882294

Variation tolerance for HERC6 Gene

Residual Variation Intolerance Score: 96.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HERC6 Gene

HapMap Linkage Disequilibrium report
HERC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HERC6 Gene

Disorders for HERC6 Gene

Relevant External Links for HERC6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HERC6
genes like me logo Genes that share disorders with HERC6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HERC6 Gene

Publications for HERC6 Gene

  1. Expression and evaluation of RING finger proteins. (PMID: 16275323) Yang Y. … Weissman A.M. (Meth. Enzymol. 2005) 23 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 67
  3. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. (PMID: 22916037) Inouye M. … de Bakker P.I. (PLoS Genet. 2012) 67
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 67
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 67

Products for HERC6 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HERC6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HERC6
    • Block miRNA regulation of HERC6 using miScript Target Protectors

    Sources for HERC6 Gene

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