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Aliases for HERC6 Gene

Aliases for HERC6 Gene

  • HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 6 2 3
  • HECT Domain And RCC1-Like Domain-Containing Protein 6 4
  • Hect Domain And RLD 6 2
  • EC 6.3.2.- 4
  • EC 6.3.2 64

External Ids for HERC6 Gene

Summaries for HERC6 Gene

Entrez Gene Summary for HERC6 Gene

  • HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HERC6 Gene

HERC6 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 6) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is HERC5.

UniProtKB/Swiss-Prot for HERC6 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERC6 Gene

Genomics for HERC6 Gene

Genomic Location for HERC6 Gene

88,378,686 bp from pter
88,443,111 bp from pter
64,426 bases
Plus strand

Genomic View for HERC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HERC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERC6 Gene

Regulatory Elements for HERC6 Gene

Proteins for HERC6 Gene

  • Protein details for HERC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable E3 ubiquitin-protein ligase HERC6
    Protein Accession:
    Secondary Accessions:
    • B4DIY5
    • Q5GC90
    • Q5GRH3
    • Q5HYM6
    • Q5JPB6
    • Q6PIF4
    • Q8NAN3
    • Q9NWS4

    Protein attributes for HERC6 Gene

    1022 amino acids
    Molecular mass:
    115126 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91303.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03879.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI46056.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI46151.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HERC6 Gene


neXtProt entry for HERC6 Gene

Proteomics data for HERC6 Gene at MOPED

Selected DME Specific Peptides for HERC6 Gene

Post-translational modifications for HERC6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys164

Other Protein References for HERC6 Gene

Domains for HERC6 Gene

Protein Domains for HERC6 Gene


  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.:
    • Q8IVU3
  • Contains 5 RCC1 repeats.:
    • Q8IVU3
genes like me logo Genes that share domains with HERC6: view

No data available for Gene Families for HERC6 Gene

Function for HERC6 Gene

Molecular function for HERC6 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for HERC6 Gene

Gene Ontology (GO) - Molecular Function for HERC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with HERC6: view

Phenotypes for HERC6 Gene

genes like me logo Genes that share phenotypes with HERC6: view

miRNA for HERC6 Gene

miRTarBase miRNAs that target HERC6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HERC6 Gene

Localization for HERC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERC6 Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for HERC6 Gene COMPARTMENTS Subcellular localization image for HERC6 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for HERC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with HERC6: view

Pathways for HERC6 Gene

SuperPathways for HERC6 Gene

No Data Available

UniProtKB/Swiss-Prot Q8IVU3-HERC6_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for HERC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with HERC6: view

No data available for Pathways by source for HERC6 Gene

Transcripts for HERC6 Gene

Unigene Clusters for HERC6 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HERC6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - -

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25
SP1: - -
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for HERC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HERC6 Gene

mRNA expression in normal human tissues for HERC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HERC6 Gene

SOURCE GeneReport for Unigene cluster for HERC6 Gene Hs.529317

mRNA Expression by UniProt/SwissProt for HERC6 Gene

Tissue specificity: Detected in brain, heart, placenta and testis.
genes like me logo Genes that share expressions with HERC6: view

Orthologs for HERC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HERC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HERC6 36
  • 98.73 (n)
  • 97.45 (a)
HERC6 37
  • 97 (a)
(Bos Taurus)
Mammalia HERC6 36
  • 82.96 (n)
  • 74.19 (a)
HERC6 37
  • 74 (a)
(Canis familiaris)
Mammalia HERC6 36
  • 82.94 (n)
  • 73.91 (a)
HERC6 37
  • 73 (a)
(Mus musculus)
Mammalia Herc6 36
  • 77.25 (n)
  • 68.04 (a)
Herc6 16
Herc6 37
  • 68 (a)
(Monodelphis domestica)
Mammalia HERC6 37
  • 57 (a)
(Rattus norvegicus)
Mammalia Herc6 36
  • 76.38 (n)
  • 65.33 (a)
(Anolis carolinensis)
Reptilia HERC6 37
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia herc6 36
  • 56.01 (n)
  • 43.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6678 37
  • 20 (a)
(Caenorhabditis elegans)
Secernentea K11D2.1 37
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 22 (a)
Species with no ortholog for HERC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HERC6 Gene

Gene Tree for HERC6 (if available)
Gene Tree for HERC6 (if available)

Paralogs for HERC6 Gene

Paralogs for HERC6 Gene

Selected SIMAP similar genes for HERC6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HERC6: view

Variants for HERC6 Gene

Sequence variations from dbSNP and Humsavar for HERC6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs764969 -- 88,409,363(-) catgg(G/T)tgact intron-variant
rs764970 -- 88,409,433(-) CACTA(G/T)CCCCC intron-variant
rs1025808 -- 88,395,195(+) ATTAT(A/T)TTATT intron-variant
rs1025809 -- 88,395,614(+) aacac(A/G)ttatt intron-variant
rs1025810 -- 88,395,793(+) tgctg(G/T)tatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HERC6 Gene

Variant ID Type Subtype PubMed ID
nsv879531 CNV Loss 21882294

Relevant External Links for HERC6 Gene

HapMap Linkage Disequilibrium report

Disorders for HERC6 Gene

No disorders were found for HERC6 Gene.

No data available for UniProtKB/Swiss-Prot for HERC6 Gene

Publications for HERC6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. (PMID: 15676274) Hochrainer K. … Kroismayr R. (Genomics 2005) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for HERC6 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HERC6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HERC6
    • Block miRNA regulation of HERC6 using miScript Target Protectors

    Sources for HERC6 Gene

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