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HERC6 Gene

protein-coding   GIFtS: 51
GCID: GC04P089299

HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase...

(Previous name: hect domain and RLD 6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family
Member 61 2
     Probable E3 Ubiquitin-Protein Ligase HERC62
Hect Domain And RLD 61 2     EC 6.3.2.-3
HECT Domain And RCC1-Like Domain-Containing Protein 62 3     EC 6.3.28
Potential Ubiquitin Ligase2     

External Ids:    HGNC: 260721   Entrez Gene: 550082   Ensembl: ENSG000001386427   OMIM: 6092495   UniProtKB: Q8IVU33   

Export aliases for HERC6 gene to outside databases

Previous GC identifers: GC04U900413 GC04P089603 GC04P089518 GC04P085051


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HERC6 Gene:
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM
179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester
with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide
exchange factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).(supplied by OMIM, Mar 2008)

GeneCards Summary for HERC6 Gene:
HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is HERC3.

UniProtKB/Swiss-Prot: HERC6_HUMAN, Q8IVU3
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HERC6 gene promoter:
         Nkx3-1 v4   AML1a   AP-4   NF-AT   Nkx3-1 v2   NF-AT4   NF-AT2   Nkx3-1 v3   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHERC6 promoter sequence
   Search Chromatin IP Primers for HERC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HERC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22

HERC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HERC6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P089299:  view genomic region     (about GC identifiers)

Start:
89,299,891 bp from pter      End:
89,364,263 bp from pter
Size:
64,373 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HERC6_HUMAN, Q8IVU3 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase HERC6  
Size: 1022 amino acids; 115126 Da
Developmental stage: Expressed in fetal brain
Sequence caution: Sequence=BAA91303.1; Type=Erroneous initiation; Sequence=BAC03879.1; Type=Erroneous initiation;
Sequence=CAI46056.1; Type=Erroneous initiation; Sequence=CAI46151.1; Type=Erroneous initiation;
Secondary accessions: B4DIY5 Q5GC90 Q5GRH3 Q5HYM6 Q5JPB6 Q6PIF4 Q8NAN3 Q9NWS4
Alternative splicing: 3 isoforms:  Q8IVU3-1   Q8IVU3-2   Q8IVU3-3   (Minor transcript)

Explore the universe of human proteins at neXtProt for HERC6: NX_Q8IVU3

Explore proteomics data for HERC6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys164
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for HERC6 (Q8IVU3)
     YHSLALSK  QVAAGGAHSF  FPLALYKKLL 


    See HERC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158608.1  NP_060382.3  

    ENSEMBL proteins: 
     ENSP00000369617   ENSP00000264346   ENSP00000425504   ENSP00000425060   ENSP00000273960  

    HERC6 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for HERC6
    Novus Biologicals HERC6 Protein
    Novus Biologicals HERC6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HERC6

     
    Search eBioscience for Proteins for HERC6 

     
    antibodies-online proteins for HERC6 (2 products) 

     
    antibodies-online peptides for HERC6

    HERC6 Antibody Products:

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    antibodies-online antibodies for HERC6 (8 products) 

    HERC6 Assay Products:

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    Cloud-Clone Corp. ELISAs for HERC6
    Cloud-Clone Corp. CLIAs for HERC6
    Search eBioscience for ELISAs for HERC6 
    antibodies-online kits for HERC6 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR000569 HECT
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry Q8IVU3

    ProtoNet protein and cluster: Q8IVU3

    1 Blocks protein domain: IPB000569 HECT domain (Ubiquitin-protein ligase)

    UniProtKB/Swiss-Prot: HERC6_HUMAN, Q8IVU3
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 5 RCC1 repeats


    Find genes that share domains with HERC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HERC6_HUMAN, Q8IVU3
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
    of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IBA--
         
    Find genes that share ontologies with HERC6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HERC6:
     Decreased Salmonella enterica   Small cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HERC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target HERC6:
    hsa-mir-16-5p (MIRT000858), hsa-mir-15a-5p (MIRT000859)

    Block miRNA regulation of human, mouse, rat HERC6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HERC6
    SwitchGear 3'UTR luciferase reporter plasmidHERC6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HERC6
    Predesigned siRNA for gene silencing in human, mouse, rat HERC6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): HERC6 (NM_017912)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HERC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERC6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HERC6
    Browse ESI BIO Cell Lines and PureStem Progenitors for HERC6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HERC6_HUMAN, Q8IVU3: Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with HERC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: HERC6_HUMAN, Q8IVU3
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HERC6: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HERC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for HERC6 (Q8IVU33 ENSP000002643464) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223923, ENSP000003655724I2D: score=1 STRING: ENSP00000365572
    HERC3Q150343, ENSP000002643454I2D: score=3 STRING: ENSP00000264345
    NME1-NME2P223923I2D: score=1 
    HERC4Q5GLZ83, ENSP000003786244I2D: score=2 STRING: ENSP00000378624
    UBQLN2Q9UHD93, ENSP000003451954I2D: score=1 STRING: ENSP00000345195
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--

    Find genes that share ontologies with HERC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HERC6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HERC6 gene (5 alternative transcripts): 
    NM_001013000.1  NM_001013002.1  NM_001013005.1  NM_001165136.1  NM_017912.3  

    Unigene Cluster for HERC6:

    HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
    Hs.529317  [show with all ESTs]
    Unigene Representative Sequence: NM_017912
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380265(uc011cdi.2 uc011cdj.2 uc011cdk.2 uc011cdl.2)
    ENST00000264346 ENST00000504905 ENST00000506714(uc003hrp.1) ENST00000502870
    ENST00000515365 ENST00000506842 ENST00000273960
    miRNA
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    Block miRNA regulation of human, mouse, rat HERC6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HERC6
    SwitchGear 3'UTR luciferase reporter plasmidHERC6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HERC6
    Predesigned siRNA for gene silencing in human, mouse, rat HERC6
    Clone
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    OriGene clones in human, mouse for HERC6 (see all 15)
    OriGene ORF clones in mouse, rat for HERC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HERC6 (NM_017912)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HERC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERC6
    Primer
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    OriGene qPCR primer pairs and template standards for HERC6
    OriGene qSTAR qPCR primer pairs in human, mouse for HERC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HERC6
      QuantiTect SYBR Green Assays in human, mouse, rat HERC6
      QuantiFast Probe-based Assays in human, mouse, rat HERC6

    Additional mRNA sequence: 

    AF336798.1 AK000644.1 AK092403.1 AK097168.1 AK225506.1 AK295832.1 AL833664.1 AY653201.1 
    BC035775.1 BC042047.1 BX647121.1 

    10 DOTS entries:

    DT.100813275  DT.453744  DT.95309357  DT.121269169  DT.97773924  DT.95086836  DT.100041833  DT.99945754 
    DT.40110711  DT.95133608 

    Selected AceView cDNA sequences (see all 75):

    T25852 CB266500 BE897383 AW014765 CB151258 AI859817 BM704522 BM905840 
    AI678618 BX116335 BF858117 CB152531 AA487676 BM988714 BC042047 AI620475 
    NM_017912 BC035775 BX647121 AL833664 AA579705 AK000644 AL832670 BG188062 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HERC6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                          -                                                     -           -                                               -               
    SP2:                          -                                                     -           -                                         -     -               
    SP3:                          -                                                     -           -     -                       -                                 
    SP4:                          -                                               -     -           -     -                       -                 -               
    SP5:                          -                                               -                                                                                 

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25
    SP1:                    -                 -         
    SP2:                    -                 -         
    SP3:                    -                 -         
    SP4:                    -                 -         
    SP5:                                                


    ECgene alternative splicing isoforms for HERC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HERC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCAGACCT
    HERC6 Expression
    About this image


    HERC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Gonad
             Primordial germ cell-like cells
     
     Esophagus (Gastrointestinal Tract)
    HERC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HERC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529317

    UniProtKB/Swiss-Prot: HERC6_HUMAN, Q8IVU3
    Tissue specificity: Detected in brain, heart, placenta and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HERC6: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HERC6
    OriGene qSTAR qPCR primer pairs in human, mouse for HERC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HERC6
    QuantiTect SYBR Green Assays in human, mouse, rat HERC6
    QuantiFast Probe-based Assays in human, mouse, rat HERC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HERC6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Herc61 , 5 hect domain and RLD 61, 5 77.25(n)1
    68.04(a)1
      6 (27.82 cM)5
    671381  NM_025992.21  NP_080268.11 
     575809925 
    lizard
    (Anolis carolinensis)
    Reptilia HERC66
    HECT and RLD domain containing E3 ubiquitin protei...
    43(a)
    1 ↔ 1
    5(45742544-45771910)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia herc61 HECT and RLD domain containing E3 ubiquitin protein more 56.01(n)
    43.7(a)
      100487734  XM_002938624.2  XP_002938670.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66786
    --
    20(a)
    1 → many
    3R(17712763-17732904)
    worm
    (Caenorhabditis elegans)
    Secernentea K11D2.16
    Protein K11D2.1 (K11D2.1) mRNA, complete cds
    21(a)
    1 → many
    I(12497460-12504938) WBGene00010768


    ENSEMBL Gene Tree for HERC6 (if available)
    TreeFam Gene Tree for HERC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HERC6 gene
    HERC32  RCCD12  HECTD22  HERC42  UBE3A2  HERC52  
    9 SIMAP similar genes for HERC6 using alignment to 3 protein entries:     HERC6_HUMAN (see all proteins):
    HERC5    HERC4    HERC3    RCCD1    DKFZp564G092    UBE3A
    SMURF2    WBSCR16    MYCBP2

    Find genes that share paralogs with HERC6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HERC6 (see all 1171)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860555101,2
    --89298158(+) AACATC/GATGAA 2 -- us2k10--------
    rs100037281,2
    C,F,A,H--89298201(+) TGGGCG/ATAGTG 2 -- us2k110Minor allele frequency- A:0.38NA WA CSA EA 258
    rs1469507841,2
    --89298295(+) GATCAC/TGCCAT 2 -- us2k10--------
    rs767565751,2
    C,F--89298345(+) CAAACA/TAACAA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs284904111,2
    C,F--89298498(+) CTGCTA/GTACTG 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1899904881,2
    --89298682(+) TGTATA/TCCAGA 2 -- us2k10--------
    rs1825880771,2
    --89298694(+) ACACAC/TAGCTT 2 -- us2k10--------
    rs755767651,2
    C--89298713(+) ACCTTC/ACTCAG 2 -- us2k12Minor allele frequency- A:0.07NA 122
    rs798293571,2
    C--89298767(+) GCCAAC/GCCTGG 2 -- us2k10--------
    rs788972791,2
    C,F--89298775(+) TGGAGT/CAATCC 2 -- us2k12Minor allele frequency- C:0.07NA 122

    HapMap Linkage Disequilibrium report for HERC6 (89299891 - 89364263 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HERC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879531CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HERC6
    DNA2.0 Custom Variant and Variant Library Synthesis for HERC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609249    OMIM disorders: --


    Find genes that share disorders with HERC6           About GenesLikeMe


    Export disorders for HERC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HERC6 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with HERC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. (PubMed id 15676274)1, 2 Hochrainer K....Kroismayr R. (Genomics 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (PLoS Genet. 2012)
    5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B. (PubMed id 18535780)1 Hochrainer K....Lipp J. (Cell. Mol. Life Sci. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55008 HGNC: 26072 AceView: HERC6 Ensembl:ENSG00000138642 euGenes: HUgn55008
    ECgene: HERC6 H-InvDB: HERC6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HERC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HERC6 gene:
    Search GeneIP for patents involving HERC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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