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HERC5 Gene

protein-coding   GIFtS: 61
GCID: GC04P089378

HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase...

(Previous name: hect domain and RLD 5)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 51 2     HECT Domain And RCC1-Like Domain-Containing Protein 52 3
CEB12 3 5     E3 ISG15--Protein Ligase HERC52
Hect Domain And RLD 51 2     Probable E3 Ubiquitin-Protein Ligase HERC52
Cyclin-E-Binding Protein 12 3     EC 6.3.2.-3
CEBP12 3     EC 6.3.28

External Ids:    HGNC: 243681   Entrez Gene: 511912   Ensembl: ENSG000001386467   OMIM: 6082425   UniProtKB: Q9UII43   

Export aliases for HERC5 gene to outside databases

Previous GC identifers: GC04P089837 GC04P089735 GC04P089597 GC04P085130


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HERC5 Gene:
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five
RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein
localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that
mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HERC5 Gene:
HERC5 (HECT and RLD domain containing E3 ubiquitin protein ligase 5) is a protein-coding gene. Diseases associated with HERC5 include mature teratoma, and liddle syndrome. GO annotations related to this gene include ubiquitin-protein ligase activity and ISG15 ligase activity. An important paralog of this gene is HERC3.

UniProtKB/Swiss-Prot: HERC5_HUMAN, Q9UII4
Function: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in
cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a
broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it
attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral
response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form
homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein
which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly
modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly
translated viral proteins are primary targets of ISG15

Gene Wiki entry for HERC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HERC5 gene promoter:
         FOXD3   FOXO3   CUTL1   NF-kappaB   HNF-3beta   Gfi-1   FOXO3b   FOXO3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHERC5 promoter sequence
   Search Chromatin IP Primers for HERC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HERC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22.1-q23

HERC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HERC5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P089378:  view genomic region     (about GC identifiers)

Start:
89,378,268 bp from pter      End:
89,427,314 bp from pter
Size:
49,047 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HERC5_HUMAN, Q9UII4 (See protein sequence)
Recommended Name: E3 ISG15--protein ligase HERC5  
Size: 1024 amino acids; 116852 Da
Subunit: Binds to CCNA1, CCNB1, CCND1 and CCNE1. Interacts with UBE2L6. Interacts with IRF3, this interaction is
marginal in resting cells but enhanced upon viral infection. Interacts with influenza A virus NS1
Caution: Was thought to be a ubiquitin ligase ubiquitinated by UBE2D1, but was confirmed by numerous studies that
it's main function is as E3 ISG15 ligase (PubMed:15331633)
Secondary accessions: B2RTQ1 Q69G20

Explore the universe of human proteins at neXtProt for HERC5: NX_Q9UII4

Explore proteomics data for HERC5 at MOPED

Post-translational modifications: 

  • ISGylated (Probable)1
  • Ubiquitination2 at Lys27, Lys447
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for HERC5 (Q9UII4)
     GQLGHNST  YHSLALSK 


    See HERC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057407.2  
    ENSEMBL proteins: 
     ENSP00000264350   ENSP00000424129  
    Reactome Protein details: Q9UII4

    HERC5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HERC5
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    Novus Biologicals HERC5 Protein
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    Browse Sino Biological Cell Lysates
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    LSBio Antibodies in human, mouse, rat for HERC5

    HERC5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HERC5
    Cloud-Clone Corp. CLIAs for HERC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR000569 HECT
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry Q9UII4

    ProtoNet protein and cluster: Q9UII4

    2 Blocks protein domains:
    IPB000408 Regulator of chromosome condensation
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: HERC5_HUMAN, Q9UII4
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 5 RCC1 repeats


    HERC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HERC5_HUMAN, Q9UII4
    Function: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in
    cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a
    broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it
    attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral
    response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form
    homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein
    which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly
    modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly
    translated viral proteins are primary targets of ISG15
    Induction: By IFNB1/IFN-beta. In endothelial cells, by TNF, IL1B/interleukin-1B and by bacterial
    lipopolysaccharides (LPS), hardly induced in other cells of the vascular wall such as primary smooth muscle cells
    and fibroblasts. By viral infection

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IBA--
    GO:0005515protein binding IPI--
    GO:0042296ISG15 ligase activity IDA--
    GO:0044822poly(A) RNA binding IDA--
         
    HERC5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HERC5:
     Increased cell death HMECs cel  Synthetic lethal with paclitax 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HERC5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HERC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HERC5

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    miRTarBase miRNAs that target HERC5:
    hsa-mir-1 (MIRT023970)

    Block miRNA regulation of human, mouse, rat HERC5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HERC5
    SwitchGear 3'UTR luciferase reporter plasmidHERC5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HERC5
    Predesigned siRNA for gene silencing in human, mouse, rat HERC5

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HERC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERC5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HERC5_HUMAN, Q9UII4: Cytoplasm, perinuclear region. Note=Associated with the polyribosomes, probably via the 60S
    subunit
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    endosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm IEA--

    HERC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HERC5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for HERC5
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    ISG15 antiviral mechanism



    HERC5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HERC5: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HERC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HERC5 (Q9UII42, 3 ENSP000002643504) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    CCNA2P202483, ENSP000002740264I2D: score=2 STRING: ENSP00000274026
    NME1-NME2P223923I2D: score=2 
    CDKN1AP389363, ENSP000002447414I2D: score=1 STRING: ENSP00000244741
    PITX2Q996973, ENSP000003041694I2D: score=1 STRING: ENSP00000304169
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS10581175
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032020ISG15-protein conjugation IDA--
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--

    HERC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HERC5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HERC5 gene: 
    NM_016323.3  

    Unigene Cluster for HERC5:

    HECT and RLD domain containing E3 ubiquitin protein ligase 5
    Hs.26663  [show with all ESTs]
    Unigene Representative Sequence: AY337518
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264350(uc003hrt.3 uc011cdm.2) ENST00000508695 ENST00000508159
    ENST00000510223 ENST00000502913
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat HERC5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HERC5
    SwitchGear 3'UTR luciferase reporter plasmidHERC5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HERC5
    Clone
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    GenScript: all cDNA clones in your preferred vector: HERC5 (NM_016323)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HERC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERC5
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HERC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HERC5
      QuantiTect SYBR Green Assays in human, mouse, rat HERC5
      QuantiFast Probe-based Assays in human, mouse, rat HERC5

    Additional mRNA sequence: 

    AB027289.1 AK302142.1 AY337518.1 BC140716.1 

    6 DOTS entries:

    DT.95262408  DT.111304  DT.100739203  DT.91928000  DT.121269175  DT.209775 

    Selected AceView cDNA sequences (see all 54):

    AA905126 AA869005 AK093155 AI217452 AI269614 BQ016184 AI201128 AA075057 
    AI336946 BM931872 CA439330 AI139751 AA813457 CB150310 CB161302 BG030610 
    BQ224310 BU195455 BG203655 BP367618 BE672545 AB027289 BX109618 AY337518 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HERC5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
    SP1:        -     -                                                                       -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                            -     -         
    SP4:              -                                                                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 24b ^ 25 ^ 26
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for HERC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HERC5 expression in normal human tissues (normalized intensities)      HERC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTTCATT
    HERC5 Expression
    About this image


    HERC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    HERC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HERC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26663

    UniProtKB/Swiss-Prot: HERC5_HUMAN, Q9UII4
    Tissue specificity: Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues
    at low levels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HERC5: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HERC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HERC5
    QuantiTect SYBR Green Assays in human, mouse, rat HERC5
    QuantiFast Probe-based Assays in human, mouse, rat HERC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HERC5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia HERC51 HECT and RLD domain containing E3 ubiquitin protein more 84.79(n)
    79.18(a)
      478474  XM_005639172.1  XP_005639229.1 
    lizard
    (Anolis carolinensis)
    Reptilia HERC56
    HECT and RLD domain containing E3 ubiquitin protei...
    32(a)
    1 ↔ 1
    5(45771972-45809992)
    zebrafish
    (Danio rerio)
    Actinopterygii HERC5 (4 of 4)6
    HERC5 (3 of 4)6
    (see all 4)
    HECT and RLD domain containing E3 ubiquitin protei...
    HECT and RLD domain containing E3 ubiquitin protei...
    (see all 4)
    32(a)
    32(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    1(51120951-51144304) ENSDARG00000075785
    1(50053444-50064622) ENSDARG00000075389
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66786
    --
    19(a)
    1 → many
    3R(17712763-17732904)
    worm
    (Caenorhabditis elegans)
    Secernentea K11D2.16
    Protein K11D2.1 (K11D2.1) mRNA, complete cds
    21(a)
    1 → many
    I(12497460-12504938) WBGene00010768


    ENSEMBL Gene Tree for HERC5 (if available)
    TreeFam Gene Tree for HERC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HERC5 gene
    HERC32  HERC62  RCCD12  HECTD22  HERC42  UBE3A2  
    6 SIMAP similar genes for HERC5 using alignment to 2 protein entries:     HERC5_HUMAN (see all proteins):
    HERC6    DKFZp564G092    UBE3A    HERC4    HERC3    HECTD2

    HERC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HERC5 (see all 825)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444478901,2
    --89376298(+) CCAAGA/GCAATT 1 -- us2k10--------
    rs1831345441,2
    --89376327(+) TGGAAC/TGACTG 1 -- us2k10--------
    rs1146757151,2
    F--89376337(+) GGAAAT/CCCATA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1885711491,2
    --89376345(+) ATAAGA/GAAAAA 1 -- us2k10--------
    rs1175835261,2
    F--89376444(+) ACAATT/CAGGCA 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1920436191,2
    --89376447(+) ATTAGG/TCATGT 1 -- us2k10--------
    rs1397318791,2
    --89376535(+) CCCAGC/GTCACA 1 -- us2k10--------
    rs1830671791,2
    --89376661(+) CCTTGA/TGGGCA 1 -- us2k10--------
    rs97843971,2
    C,F,A,H--89376717(+) ttgtgG/Aggcag 1 -- us2k114Minor allele frequency- A:0.46NS EA NA WA CSA 785
    rs1877038221,2
    --89376743(+) GGGACC/TCTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HERC5 (89378268 - 89427314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HERC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879531CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HERC5
    DNA2.0 Custom Variant and Variant Library Synthesis for HERC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608242    OMIM disorders: --

    10 diseases for HERC5:    About MalaCards
    mature teratoma    liddle syndrome    teratoma    angelman syndrome
    endotheliitis    influenza    hiv-1    asthma
    hepatocellular carcinoma    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for HERC5:
    Liddle syndrome

    HERC5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HERC5

    Export disorders for HERC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HERC5 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with HERC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. (PubMed id 10581175)1, 2, 3 Mitsui K.... Ohtsubo M. (Biochem. Biophys. Res. Commun. 1999)
    2. HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells. (PubMed id 15331633)1, 2, 9 Kroismayr R....Lipp J. (J. Cell Sci. 2004)
    3. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975)1, 2, 9 Wong J.J.... Chin K.C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    4. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012)
    5. Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification. (PubMed id 20308324)1, 2 Shi H.X....Wang C. (Mol. Cell. Biol. 2010)
    6. Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells. (PubMed id 16407192)1, 2 Dastur A.... Huibregtse J.M. (J. Biol. Chem. 2006)
    7. Identification and Herc5-mediated ISGylation of novel target proteins. (PubMed id 16884686)1, 2 Takeuchi T.... Yokosawa H. (Biochem. Biophys. Res. Commun. 2006)
    8. Paternal lifestyle as a potential source of germline mutations transmitted to offspring. (PubMed id 23538710)1 Linschooten J.O....Godschalk R.W. (FASEB J. 2013)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51191 HGNC: 24368 AceView: HERC5 Ensembl:ENSG00000138646 euGenes: HUgn51191
    ECgene: HERC5 H-InvDB: HERC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HERC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HERC5 gene:
    Search GeneIP for patents involving HERC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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