Aliases for HERC4 Gene
Aliases for HERC4 Gene
External Ids for HERC4 Gene
- HGNC: 24521
- Entrez Gene: 26091
- Ensembl: ENSG00000148634
- OMIM: 609248
- UniProtKB: Q5GLZ8
Previous GeneCards Identifiers for HERC4 Gene
- GC10M069027
- GC10M069351
- GC10M069681
- GC10M063681
Summaries for HERC4 Gene
-
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
GeneCards Summary for HERC4 Gene
HERC4 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is HERC3.
UniProtKB/Swiss-Prot for HERC4 Gene
-
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERC4 Gene
Genomics for HERC4 Gene
Regulatory Elements for HERC4 Gene
Enhancers for HERC4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HERC4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HERC4 gene promoter:
Regulatory Element Products
Genomic Location for HERC4 Gene
- Chromosome:
- 10
- Start:
- 67,921,899 bp from pter
- End:
- 68,075,348 bp from pter
- Size:
- 153,450 bases
- Orientation:
- Minus strand
Genomic View for HERC4 Gene
Genes around HERC4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q21.3 by Ensembl
- 10q21.3 by Entrez Gene
- 10q21.3 by HGNC
HERC4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HERC4 Gene
Proteins for HERC4 Gene
-
Protein details for HERC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5GLZ8-HERC4_HUMAN
- Recommended name:
- Probable E3 ubiquitin-protein ligase HERC4
- Protein Accession:
- Q5GLZ8
- Q5GC98
- Q5GC99
- Q5GCA0
- Q8IXP9
- Q9HCH9
Protein attributes for HERC4 Gene
- Size:
- 1057 amino acids
- Molecular mass:
- 118563 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB13419.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for HERC4 Gene
Selected DME Specific Peptides for HERC4 Gene
- Q5GLZ8:
-
- GQLGHNST
- FLLFLTGSDRIPI
- NLLDLPKY
- GQVYAWG
- QVAAGGAHSF
- GGVFTFGAG
- EETFCLNFTI
- YHSLALSK
- NRQEFVDAYV
- TIKIFWEV
- FPLALYKKLL
Post-translational modifications for HERC4 Gene
Other Protein References for HERC4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HERC4
- Novus Biologicals Antibodies for HERC4
-
Abcam antibodies for HERC4
- Invitrogen Antibodies for HERC4
- antibodies-online Antibodies for HERC4: See all 45
- GeneTex Kcnj1 antibody for HERC4
- GeneTex HERC4 antibody for HERC4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HERC4
- Origene Custom Protein Services for HERC4
- Novus Biologicals proteins for HERC4
- Search GeneTex for Proteins for HERC4
-
Abcam proteins for HERC4
Assay Products
Domains & Families for HERC4 Gene
Protein Domains for HERC4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HERC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HERC4 Gene
Function for HERC4 Gene
Molecular function for HERC4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
Enzyme Numbers (IUBMB) for HERC4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for HERC4 Gene
- MGI mutant phenotypes for HERC4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HERC4:
Animal Models for HERC4 Gene
- MGI Knock Outs for HERC4:
-
- Herc4 tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HERC4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HERC4 gene
- Search ViGene Biosciences for HERC4
CRISPR Products
-
OriGene CRISPR knockouts for HERC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HERC4
- GenScript: Design CRISPR guide RNA sequences for HERC4
miRNA for HERC4 Gene
- miRTarBase miRNAs that target HERC4
miRNA Products
- Search ViGene Biosciences for HERC4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HERC4
- Browse OriGene Inhibitory RNA Products For HERC4
-
ViGene Biosciences ready-to-package AAV shRNAs for HERC4 gene
Cell Line Products
-
Horizon Cell Lines for HERC4
-
ViGene Biosciences adenoviral particle packaged cDNA for HERC4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HERC4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HERC4 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HERC4 Gene
Localization for HERC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HERC4 Gene
- Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HERC4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Ubiquitin mediated proteolysis | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for HERC4 Gene
4 Reactome pathways for HERC4 Gene
1 KEGG pathway for HERC4 Gene
UniProtKB/Swiss-Prot Q5GLZ8-HERC4_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for HERC4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007283 | spermatogenesis | ISS | 17967448 |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for HERC4 Gene
Transcripts for HERC4 Gene
mRNA/cDNA for HERC4 Gene
- (13) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HERC4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HERC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HERC4
- GenScript: Design CRISPR guide RNA sequences for HERC4
miRNA Products
- Search ViGene Biosciences for HERC4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HERC4
- Browse OriGene Inhibitory RNA Products For HERC4
-
ViGene Biosciences ready-to-package AAV shRNAs for HERC4 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | |||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: |
Expression for HERC4 Gene
This gene is overexpressed in Heart (15.6) and Lymph node (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HERC4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HERC4 Gene:
HERC4SOURCE GeneReport for Unigene cluster for HERC4 Gene:
Hs.51891mRNA Expression by UniProt/SwissProt for HERC4 Gene:
Q5GLZ8-HERC4_HUMAN
Tissue specificity:
Expressed in brain and testis and detected in heart and placenta.
Evidence on tissue expression from TISSUES for HERC4 Gene
- Nervous system(4.7)
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for HERC4
-
OriGene qPCR primer pairs and template standards for HERC4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HERC4 Gene
Orthologs for HERC4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HERC4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HERC4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HERC4 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HERC4 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Herc4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Herc4 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HERC4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-mir-1772 35 |
|
OneToOne | |
| HERC4 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | HERC4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | herc4 34 |
|
||
| Str.10009 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3006 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | HERC4 35 |
|
OneToOne | |
| herc4 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9153 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006994 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | herc-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HUL4 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | UVR8 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0435700 34 |
|
- Species where no ortholog for HERC4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HERC4 Gene
(13) SIMAP similar genes for HERC4 Gene using alignment to 4 proteins:
Variants for HERC4 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002975 | -- | 68,069,441(+) | AACAT(A/G)AACAT | intron-variant, utr-variant-3-prime | |
| rs1000025051 | -- | 68,072,236(+) | ATGAA(A/G)TGTGA | intron-variant | |
| rs1000027469 | -- | 68,071,379(+) | ACCTA(A/G)GTAAC | intron-variant | |
| rs1000046380 | -- | 67,948,677(+) | GCACT(C/T)TGGGA | intron-variant | |
| rs1000057699 | -- | 68,072,003(+) | CAGAA(A/G)CCACC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2676451 | CNV | deletion | 23128226 |
| esv3546449 | CNV | deletion | 23714750 |
| esv3623696 | CNV | loss | 21293372 |
| esv3623697 | CNV | gain | 21293372 |
| esv3623698 | CNV | gain | 21293372 |
| esv3623699 | CNV | loss | 21293372 |
| esv3623700 | CNV | loss | 21293372 |
| nsv551433 | CNV | loss | 21841781 |
| nsv6977 | CNV | insertion | 18451855 |
| nsv948045 | CNV | duplication | 23825009 |
| nsv948046 | CNV | duplication | 23825009 |
| nsv958575 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
8.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.41;
27.70% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HERC4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HERC4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HERC4 Gene
Disorders for HERC4 Gene
Relevant External Links for HERC4
No disorders were found for HERC4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HERC4 Gene
Publications for HERC4 Gene
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
- The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. (PMID: 15676274) Hochrainer K. … Kroismayr R. (Genomics 2005) 3 4 64
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
Products for HERC4 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for HERC4
- Browse OriGene ELISA Kits
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HERC4
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- OriGene qPCR primer pairs and template standards for HERC4
- OriGene qPCR primer pairs for HERC4
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- GenScript: Design CRISPR guide RNA sequences for HERC4
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- Novus Biologicals Antibodies for HERC4
- Novus Biologicals proteins for HERC4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HERC4
- Abcam proteins for HERC4
- Search for Assays for HERC4 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- GeneTex Kcnj1 antibody for HERC4
- GeneTex HERC4 antibody for HERC4
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- ViGene Biosciences adenoviral particle packaged cDNA for HERC4 gene
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- Horizon Cell Lines for HERC4
- Cyagen custom Knockout/knockin (KOKI) mouse models for HERC4
- VectorBuilder custom plasmid, inducible vectors for HERC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HERC4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HERC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer