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Aliases for HERC4 Gene

Aliases for HERC4 Gene

  • HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4 2 3
  • HECT Domain And RCC1-Like Domain-Containing Protein 4 4
  • Hect Domain And RLD 4 2
  • EC 6.3.2.- 4
  • KIAA1593 4
  • EC 6.3.2 63

External Ids for HERC4 Gene

Previous GeneCards Identifiers for HERC4 Gene

  • GC10M069027
  • GC10M069351
  • GC10M069681
  • GC10M063681

Summaries for HERC4 Gene

Entrez Gene Summary for HERC4 Gene

  • HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HERC4 Gene

HERC4 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4) is a Protein Coding gene. Diseases associated with HERC4 include breast benign neoplasm and thoracic benign neoplasm. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is HERC5.

UniProtKB/Swiss-Prot for HERC4 Gene

  • Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERC4 Gene

Genomics for HERC4 Gene

Regulatory Elements for HERC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HERC4 Gene

Chromosome:
10
Start:
67,921,899 bp from pter
End:
68,075,348 bp from pter
Size:
153,450 bases
Orientation:
Minus strand

Genomic View for HERC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HERC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERC4 Gene

Proteins for HERC4 Gene

  • Protein details for HERC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GLZ8-HERC4_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase HERC4
    Protein Accession:
    Q5GLZ8
    Secondary Accessions:
    • Q5GC98
    • Q5GC99
    • Q5GCA0
    • Q8IXP9
    • Q9HCH9

    Protein attributes for HERC4 Gene

    Size:
    1057 amino acids
    Molecular mass:
    118563 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13419.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for HERC4 Gene

neXtProt entry for HERC4 Gene

Proteomics data for HERC4 Gene at MOPED

Post-translational modifications for HERC4 Gene

  • Ubiquitination at Lys 132, Lys 365, Lys 469, Lys 488, Lys 493, and Lys 890
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for HERC4

Domains & Families for HERC4 Gene

Suggested Antigen Peptide Sequences for HERC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q5GLZ8

UniProtKB/Swiss-Prot:

HERC4_HUMAN :
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 7 RCC1 repeats.
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Similarity:
  • Contains 7 RCC1 repeats.
genes like me logo Genes that share domains with HERC4: view

No data available for Gene Families for HERC4 Gene

Function for HERC4 Gene

Molecular function for HERC4 Gene

UniProtKB/Swiss-Prot Function:
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity).

Enzyme Numbers (IUBMB) for HERC4 Gene

Gene Ontology (GO) - Molecular Function for HERC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0016874 ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with HERC4: view
genes like me logo Genes that share phenotypes with HERC4: view

Animal Model Products

miRNA for HERC4 Gene

miRTarBase miRNAs that target HERC4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HERC4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for HERC4 Gene

Localization for HERC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERC4 Gene

Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HERC4 Gene COMPARTMENTS Subcellular localization image for HERC4 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for HERC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with HERC4: view

Pathways & Interactions for HERC4 Gene

genes like me logo Genes that share pathways with HERC4: view

Pathways by source for HERC4 Gene

1 KEGG pathway for HERC4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q5GLZ8-HERC4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for HERC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis ISS 17967448
GO:0016567 protein ubiquitination IEA --
GO:0030154 cell differentiation IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process --
genes like me logo Genes that share ontologies with HERC4: view

No data available for SIGNOR curated interactions for HERC4 Gene

Drugs & Compounds for HERC4 Gene

No Compound Related Data Available

Transcripts for HERC4 Gene

Unigene Clusters for HERC4 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HERC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HERC4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: -
SP4: - - - - -
SP5:
SP6: - - -
SP7: - - - -
SP8:
SP9: -
SP10:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HERC4 Gene

GeneLoc Exon Structure for
HERC4
ECgene alternative splicing isoforms for
HERC4

Expression for HERC4 Gene

mRNA expression in normal human tissues for HERC4 Gene

Protein differential expression in normal tissues from HIPED for HERC4 Gene

This gene is overexpressed in Heart (15.6) and Lymph node (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HERC4 Gene



SOURCE GeneReport for Unigene cluster for HERC4 Gene Hs.51891

mRNA Expression by UniProt/SwissProt for HERC4 Gene

Q5GLZ8-HERC4_HUMAN
Tissue specificity: Expressed in brain and testis and detected in heart and placenta.
genes like me logo Genes that share expression patterns with HERC4: view

Protein tissue co-expression partners for HERC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HERC4 Gene

Orthologs for HERC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HERC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HERC4 35
  • 94.77 (n)
  • 97.54 (a)
HERC4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HERC4 35
  • 95.65 (n)
  • 98.11 (a)
HERC4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Herc4 35
  • 91.64 (n)
  • 96.78 (a)
Herc4 16
Herc4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HERC4 35
  • 99.68 (n)
  • 99.62 (a)
HERC4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Herc4 35
  • 91.86 (n)
  • 96.97 (a)
oppossum
(Monodelphis domestica)
Mammalia HERC4 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HERC4 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves HERC4 35
  • 81.98 (n)
  • 88.26 (a)
gga-mir-1772 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HERC4 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia herc4 35
  • 74.32 (n)
  • 80.08 (a)
Str.10009 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3006 35
zebrafish
(Danio rerio)
Actinopterygii herc4 35
  • 68.03 (n)
  • 75.6 (a)
HERC4 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006994 35
  • 49.87 (n)
  • 47.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9153 35
  • 50.79 (n)
  • 46.58 (a)
CG9153 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea herc-1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUL4 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UVR8 35
  • 47.92 (n)
  • 38.98 (a)
rice
(Oryza sativa)
Liliopsida Os04g0435700 35
  • 46.73 (n)
  • 38.87 (a)
Species with no ortholog for HERC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HERC4 Gene

ENSEMBL:
Gene Tree for HERC4 (if available)
TreeFam:
Gene Tree for HERC4 (if available)

Paralogs for HERC4 Gene

Paralogs for HERC4 Gene

(13) SIMAP similar genes for HERC4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HERC4: view

Variants for HERC4 Gene

Sequence variations from dbSNP and Humsavar for HERC4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs14819 -- 67,922,094(+) TTCAA(A/G)GAAAT utr-variant-3-prime
rs14840 -- 67,922,874(-) TTTTT(C/T)TTGTG utr-variant-3-prime
rs471341 -- 68,068,453(-) ctggc(A/G)tgcag intron-variant
rs474391 -- 67,963,972(+) AGGAA(G/T)AGTTT intron-variant
rs482806 -- 68,032,181(+) GTAAA(C/G)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HERC4 Gene

Variant ID Type Subtype PubMed ID
nsv6977 CNV Insertion 18451855
esv2676451 CNV Deletion 23128226
dgv766n71 CNV Gain 21882294
dgv767n71 CNV Gain 21882294
nsv895687 CNV Gain 21882294

Variation tolerance for HERC4 Gene

Residual Variation Intolerance Score: 8.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HERC4 Gene

HapMap Linkage Disequilibrium report
HERC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HERC4 Gene

Disorders for HERC4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HERC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast benign neoplasm
thoracic benign neoplasm
  • benign neoplasm of thorax
- elite association
Search HERC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HERC4

Genetic Association Database (GAD)
HERC4
Human Genome Epidemiology (HuGE) Navigator
HERC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HERC4
genes like me logo Genes that share disorders with HERC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HERC4 Gene

Publications for HERC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 67

Products for HERC4 Gene

Sources for HERC4 Gene

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