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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HERC4 Gene

protein-coding   GIFtS: 53
GCID: GC10M069681

HECT and RLD domain containing E3 ubiquitin protein ligase...

(Previous name: hect domain and RLD 4 )
 Explore 2 diseases affiliated with
HERC4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HERC4    

Aliases
for HERC4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 41 2     DKFZP564G0921
Hect Domain And RLD 41 2     Probable E3 Ubiquitin-Protein Ligase HERC42
KIAA15931 3     EC 6.3.2.-3
HECT Domain And RCC1-Like Domain-Containing Protein 42 3     EC 6.3.28

External Ids:    HGNC: 245211   Entrez Gene: 260912   Ensembl: ENSG000001486347   OMIM: 6092485   UniProtKB: Q5GLZ83   

Export aliases for HERC4 gene to outside databases

Previous GC identifers: GC10M069027 GC10M069351 GC10M063681


Summaries
for HERC4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HERC4:
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM
179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with
ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange
factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: HERC4_HUMAN, Q5GLZ8
Function: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of
cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic
droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in
the form of a thioester and then directly transfer it to targeted substrates (By similarity)




Genomic Views
for HERC4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HERC4 gene promoter:
         AhR   Arnt   RORalpha2   AREB6   RORalpha1   FOXJ2 (long isoform)   Chx10   FOXJ2   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HERC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HERC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HERC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC chromosome: 10

HERC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HERC4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M069681:  view genomic region     (about GC identifiers)

Start:
 69,681,656 bp from pter      End:
 69,835,105 bp from pter
Size:
 153,450 bases      Orientation:
 minus strand

Proteins
for HERC4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HERC4_HUMAN, Q5GLZ8 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase HERC4  
Size: 1057 amino acids; 118563 Da
Subcellular location: Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution
Developmental stage: Expressed in fetal brain
Sequence caution: Sequence=BAB13419.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5GC98 Q5GC99 Q5GCA0 Q8IXP9 Q9HCH9
Alternative splicing: 6 isoforms:  Q5GLZ8-1   Q5GLZ8-2   Q5GLZ8-3   Q5GLZ8-4   Q5GLZ8-5   Q5GLZ8-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HERC4: NX_Q5GLZ8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5GLZ8

    • 4/11 DME Specific Peptides for HERC4 (Q5GLZ8) (see all 11)
     GQVYAWG  GQLGHNST  TIKIFWEV  YHSLALSK 

    HERC4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_056416.2  NP_071362.1  

    ENSEMBL proteins: 
     ENSP00000277817   ENSP00000416504   ENSP00000378624   ENSP00000406171   ENSP00000423671  
     ENSP00000362804   ENSP00000427191   ENSP00000422383   ENSP00000426563   ENSP00000378614  

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    Uscn Proteins for HERC4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol IEA--


    HERC4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HERC4

    Protein Domains /
    Families
    for HERC4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HERC4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009091 Reg_csome_cond/b-lactamase_inh
     IPR000569 HECT
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry Q5GLZ8

    ProtoNet protein and cluster: Q5GLZ8

    2 Blocks protein families:
    IPB000408 Regulator of chromosome condensation
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: HERC4_HUMAN, Q5GLZ8
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 7 RCC1 repeats


    Function
    for HERC4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HERC4_HUMAN, Q5GLZ8
    Function: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of
    cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic
    droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in
    the form of a thioester and then directly transfer it to targeted substrates (By similarity)

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
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    hsa-miR-361-5p hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-25 hsa-miR-374a hsa-miR-342-3p hsa-miR-197 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmid: HERC4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HERC4 (see all 7)
    OriGene shRNA RFP: HERC4
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IBA--


    HERC4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HERC4:
     Decreased influenza A/WSN/33 r  Increased cell death in HCC-19 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Herc4):
     reproductive system 

    HERC4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HERC4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Ubiquitin mediated proteolysis0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for HERC4):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: HERC4_HUMAN, Q5GLZ8
    Pathway: Protein modification; protein ubiquitination


    HERC4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HERC4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HERC4 (Q5GLZ83 ENSP000003786244) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HERC6Q8IVU33, ENSP000002643464I2D: score=2 STRING: ENSP00000264346
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis ISS17967448
    GO:0030154cell differentiation IEA--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--


    HERC4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HERC4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HERC4
    Search CenterWatch for drugs/clinical trials and news about HERC4 

    Transcripts
    for HERC4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HERC4 gene (3 alternative transcripts): 
    NM_001017972.1  NM_015601.3  NM_022079.2  

    Unigene Cluster for HERC4:

    HECT and RLD domain containing E3 ubiquitin protein ligase 4
    Hs.51891  [show with all ESTs]
    Unigene Representative Sequence: NM_022079
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000277817(uc009xpq.3) ENST00000412272(uc009xpr.3) ENST00000395198(uc001jng.4 uc001jnh.4 uc001jni.4)
    ENST00000427635(uc001jnf.4) ENST00000473533 ENST00000373700 ENST00000480158
    ENST00000460168(uc021prr.1) ENST00000463478 ENST00000513996 ENST00000395185
    ENST00000505760 ENST00000492996(uc001jnk.3) ENST00000506515 ENST00000515753
    ENST00000395187

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HERC4
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate HERC4 (see all 27):
    hsa-miR-361-5p hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-25 hsa-miR-374a hsa-miR-342-3p hsa-miR-197 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmid: HERC4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HERC4 (see all 7)
    OriGene shRNA RFP: HERC4
    OriGene siRNA: HERC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HERC4
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HERC4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HERC4

    Additional cDNA sequence: 

    AB046813.1 AK026808.1 AK027835.1 AK292809.1 AY221963.1 AY650033.1 AY650034.1 BC015043.1 
    BC018114.1 BC039465.1 BC039600.1 

    16 DOTS entries:

    DT.314703  DT.95364733  DT.92426984  DT.100797241  DT.95372946  DT.100640722  DT.104048  DT.100658746 
    DT.101968121  DT.121277435  DT.95362282  DT.97843516  DT.100797242  DT.92426983  DT.97819751  DT.95237347 

    24/122 AceView cDNA sequences (see all 122):

    AI300250 CB178436 N32787 AI886088 BC018114 AA227914 CA848201 CB178675 
    BG213191 AA907185 AI810059 N69341 CF530071 AA227626 BQ721985 AI868630 
    CO245364 AI123750 BM761599 BM127033 AA887267 AA815054 BM126473 AA703945 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HERC4 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:              -     -     -     -                 -     -                                                                             -                     
    SP2:              -     -     -     -     -     -     -     -                       -     -                                               -                     
    SP3:                                                                                                                                      -                     
    SP4:              -     -     -     -                       -                                                                                                   
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for HERC4

    Expression
    for HERC4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HERC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAGAAACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HERC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HERC4

    SOURCE GeneReport for Unigene cluster: Hs.51891

    UniProtKB/Swiss-Prot: HERC4_HUMAN, Q5GLZ8
    Tissue specificity: Expressed in brain and testis and detected in heart and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including HERC4: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for HERC4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HERC4 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HERC41 hect domain and RLD 4 81.98(n)
    88.26(a)    		   423683  XM_001231233.2  XP_001231234.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HERC46
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL343215.1(1312556-1337175)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.30062 Xenopus laevis transcribed sequence with weak similarity more 78.7(n)    BX844320.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii herc41 hect domain and RLD 4 68.03(n)
    75.6(a)    		   557513  XM_680593.5  XP_685685.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG91531 CG9153 51.01(n)
    46.77(a)    		   38151  NM_138254.2  NP_612098.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea herc-16
    		 --
    		 35(a)
    		 1 → many
    		 I(1211493-1254700)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UVR81 protein UV-B resistance 8 47.92(n)
    38.98(a)    		   836506  NM_125781.3  NP_201191.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g04357001 hypothetical protein 46.84(n)
    39.2(a)    		   4335903  NM_001059384.1  NP_001052849.1 


    ENSEMBL Gene Tree for HERC4 (if available)
    TreeFam Gene Tree for HERC4 (if available) 

    Paralogs
    for HERC4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HERC4 gene
    HERC12  HECTD22  HECTD32  HERC22  HERC32  RCCD12  HERC62  UBE3A2  
    HERC52  
    18 SIMAP similar genes for HERC4 using alignment to 4 protein entries:     HERC4_HUMAN (see all proteins):
    DKFZp564G092    KIAA1651    FAM138D    FAM138A    FAM138B    FAM138C
    FAM138F    UBE3A    HERC3    HERC6    HERC5    DKFZp564H223
    HECTD2    HUWE1    RCBTB2    SMURF2    WWP2    RCC1

    HERC4 for paralogs           About GeneDecksing



    Genomic Variants
    for HERC4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2388 NCBI SNPs in HERC4 are shown (see all 2388)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs747414991,2
    		F,--69681272(+) TTCTAT/CCTATA 2 -- int11Minor allele frequency- C:0.07WA 118
    rs745419251,2
    		C,F,--69681418(+) ATAGCG/TGTCAT 2 -- int11Minor allele frequency- T:0.16WA 118
    rs41419191,2
    		C,F,H,--69681567(+) CATGTG/AGGAAT 2 -- int120Minor allele frequency- A:0.03NS EA NA WA CSA 1434
    rs1178112411,2
    		F,--69681670(+) AAATAT/ATAAAA 2 -- ut311Minor allele frequency- A:0.04EA 120
    rs1869337241,2
    		--69681704(+) TTCACA/GGCATT 2 -- ut310--------
    rs122559821,2
    		C,F,H,--69681759(+) TCACAT/AGTATT 2 -- ut31 ese35Minor allele frequency- A:0.02NS WA CSA 338
    rs1439633451,2
    		--69681881(+) ATCAAC/TAATTT 2 -- ut310--------
    rs1900504361,2
    		--69681956(+) GTGGAA/GACAGA 2 -- ut310--------
    rs1826394651,2
    		--69681962(+) ACAGAA/GTTCTT 2 -- ut310--------
    rs1486013211,2
    		--69682022(+) AGTGTA/GTCAGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HERC4 (69681656 - 69835105 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HERC4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HERC4
    DNA2.0 Custom Variant and Variant Library Synthesis for HERC4

    Disorders / Diseases
    for HERC4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HERC4 for disorders           About GeneDecksing

    OMIM gene information: 609248    OMIM disorders: --

    2 diseases for HERC4:    About MalaCards
    alzheimer's disease    malaria

    Human Genome Epidemiology (HuGE) Navigator: HERC4 (2 documents)

    Export disorders for HERC4 gene to outside databases

    Publications
    for HERC4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HERC4 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with HERC4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. (PubMed id 15676274)1, 2 Hochrainer K....Kroismayr R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. A human ubiquitin conjugating enzyme (E2)-HECT E3 liga se structure-function screen. (PubMed id 22496338)1 Sheng Y....Dhe-Paganon S. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for HERC4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HERC4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26091 HGNC: 24521 AceView: HERC4 Ensembl:ENSG00000148634 euGenes: HUgn26091
    ECgene: HERC4 Kegg: 26091 H-InvDB: HERC4

    Other Databases showing HERC4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1593

    Specialized Databases showing HERC4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HERC4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HERC4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HERC4 gene:
    Search GeneIP for patents involving HERC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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