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Aliases for HERC3 Gene

Aliases for HERC3 Gene

  • HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 3 2 3 5
  • HECT Domain And RCC1-Like Domain-Containing Protein 3 4
  • Hect Domain And RLD 3 2
  • EC 6.3.2.- 4
  • KIAA0032 4
  • EC 6.3.2 63

External Ids for HERC3 Gene

Previous GeneCards Identifiers for HERC3 Gene

  • GC04P089671
  • GC04P089815
  • GC04P089906
  • GC04P089972
  • GC04P089870
  • GC04U900479
  • GC04P089513
  • GC04P085266
  • GC04P089444

Summaries for HERC3 Gene

Entrez Gene Summary for HERC3 Gene

  • This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

GeneCards Summary for HERC3 Gene

HERC3 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is HERC5.

UniProtKB/Swiss-Prot for HERC3 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERC3 Gene

Genomics for HERC3 Gene

Regulatory Elements for HERC3 Gene

Enhancers for HERC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HERC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HERC3 Gene

Chromosome:
4
Start:
88,521,048 bp from pter
End:
88,709,297 bp from pter
Size:
188,250 bases
Orientation:
Plus strand

Genomic View for HERC3 Gene

Genes around HERC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HERC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HERC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERC3 Gene

Proteins for HERC3 Gene

  • Protein details for HERC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15034-HERC3_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase HERC3
    Protein Accession:
    Q15034
    Secondary Accessions:
    • A8K1S5
    • Q8IXX3

    Protein attributes for HERC3 Gene

    Size:
    1050 amino acids
    Molecular mass:
    117188 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA04945.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HERC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HERC3 Gene

Proteomics data for HERC3 Gene at MOPED

Selected DME Specific Peptides for HERC3 Gene

Post-translational modifications for HERC3 Gene

  • Ubiquitinated; which promotes degradation by the proteasome.
  • Ubiquitination at Lys 63 and Lys 920
  • Modification sites at PhosphoSitePlus

Domains & Families for HERC3 Gene

Suggested Antigen Peptide Sequences for HERC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15034

UniProtKB/Swiss-Prot:

HERC3_HUMAN :
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 7 RCC1 repeats.
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Similarity:
  • Contains 7 RCC1 repeats.
genes like me logo Genes that share domains with HERC3: view

No data available for Gene Families for HERC3 Gene

Function for HERC3 Gene

Molecular function for HERC3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for HERC3 Gene

Gene Ontology (GO) - Molecular Function for HERC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with HERC3: view
genes like me logo Genes that share phenotypes with HERC3: view

Animal Models for HERC3 Gene

MGI Knock Outs for HERC3:

Animal Model Products

miRNA for HERC3 Gene

miRTarBase miRNAs that target HERC3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HERC3 Gene

Localization for HERC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERC3 Gene

Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HERC3 Gene COMPARTMENTS Subcellular localization image for HERC3 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for HERC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HERC3: view

Pathways & Interactions for HERC3 Gene

genes like me logo Genes that share pathways with HERC3: view

UniProtKB/Swiss-Prot Q15034-HERC3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for HERC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with HERC3: view

No data available for SIGNOR curated interactions for HERC3 Gene

Drugs & Compounds for HERC3 Gene

No Compound Related Data Available

Transcripts for HERC3 Gene

mRNA/cDNA for HERC3 Gene

(9) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HERC3 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HERC3 Gene

No ASD Table

Relevant External Links for HERC3 Gene

GeneLoc Exon Structure for
HERC3
ECgene alternative splicing isoforms for
HERC3

Expression for HERC3 Gene

mRNA expression in normal human tissues for HERC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HERC3 Gene

This gene is overexpressed in Urine (13.4), Platelet (13.3), Colon muscle (12.1), Plasma (10.6), and Stomach (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HERC3 Gene



SOURCE GeneReport for Unigene cluster for HERC3 Gene Hs.35804

genes like me logo Genes that share expression patterns with HERC3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HERC3 Gene

Orthologs for HERC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HERC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HERC3 35
  • 91.97 (n)
  • 97.9 (a)
HERC3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HERC3 35
  • 93.59 (n)
  • 98.76 (a)
HERC3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Herc3 35
  • 89.08 (n)
  • 95.33 (a)
Herc3 16
Herc3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HERC3 35
  • 98.16 (n)
  • 98.26 (a)
rat
(Rattus norvegicus)
Mammalia Herc3 35
  • 89.08 (n)
  • 95.62 (a)
oppossum
(Monodelphis domestica)
Mammalia HERC3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HERC3 35
  • 79.62 (n)
  • 87.71 (a)
HERC3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HERC3 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia herc3 35
  • 72.06 (n)
  • 77.62 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16537 35
herc3 35
  • 64.91 (n)
  • 66.76 (a)
herc3 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7420 35
fruit fly
(Drosophila melanogaster)
Insecta CG9153 37
  • 44 (a)
CG9153 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G8AL.1 37
  • 33 (a)
herc-1 35
  • 47.12 (n)
  • 36.48 (a)
herc-1 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUL4 36
  • 22 (a)
OneToMany
Species with no ortholog for HERC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HERC3 Gene

ENSEMBL:
Gene Tree for HERC3 (if available)
TreeFam:
Gene Tree for HERC3 (if available)

Paralogs for HERC3 Gene

Paralogs for HERC3 Gene

genes like me logo Genes that share paralogs with HERC3: view

Variants for HERC3 Gene

Sequence variations from dbSNP and Humsavar for HERC3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1804080 - 88,704,276(+) AACTG(C/G)AAGAG reference, missense
rs1020592 -- 88,691,229(+) ATTTC(A/G)GTTTT intron-variant
rs1020593 -- 88,691,293(+) ATGTA(C/T)ATGTC intron-variant
rs1271376 -- 88,625,444(-) catgt(A/G)taaca intron-variant
rs1804081 -- 88,707,015(+) GAGGC(C/T)TATAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HERC3 Gene

Variant ID Type Subtype PubMed ID
nsv461575 CNV Gain 19166990
esv2640318 CNV Deletion 19546169
esv2278581 CNV Deletion 18987734
esv5387 CNV Deletion 18987735
esv2727952 CNV Deletion 23290073
esv2657218 CNV Deletion 23128226
nsv291508 CNV Loss 16902084
nsv461576 CNV Gain 19166990
esv1953449 CNV Deletion 18987734
esv2727953 CNV Deletion 23290073

Variation tolerance for HERC3 Gene

Residual Variation Intolerance Score: 6.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.28; 85.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HERC3 Gene

Disorders for HERC3 Gene

Relevant External Links for HERC3

Genetic Association Database (GAD)
HERC3
Human Genome Epidemiology (HuGE) Navigator
HERC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HERC3

No disorders were found for HERC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HERC3 Gene

Publications for HERC3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The human HERC3 gene maps to chromosome 4q21 by fluorescence in situ hybridization. (PMID: 10702688) Cruz C. … Rosa J.L. (Cytogenet. Cell Genet. 1999) 2 3
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The ubiquitin ligase HERC3 attenuates NF-I_B-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. (PMID: 26476452) Hochrainer K. … Anrather J. (Nucleic Acids Res. 2015) 3

Products for HERC3 Gene

Sources for HERC3 Gene

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