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GIFtS

HERC3 Gene

protein-coding   GIFtS: 55
GCID: GC04P089444

HECT and RLD domain containing E3 ubiquitin protein ligase...

(Previous name: hect domain and RLD 3 )
 Explore 1 disease affiliated with
HERC3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HERC3    

Aliases
for HERC3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 31 2     Probable E3 Ubiquitin-Protein Ligase HERC32
Hect Domain And RLD 31 2     EC 6.3.2.-3
KIAA00321 3     EC 6.3.28
HECT Domain And RCC1-Like Domain-Containing Protein 32 3     

External Ids:    HGNC: 48761   Entrez Gene: 89162   Ensembl: ENSG000001386417   OMIM: 6052005   UniProtKB: Q150343   

Export aliases for HERC3 gene to outside databases

Previous GC identifers: GC04P089671 GC04P089815 GC04P089906 GC04P089972 GC04P089870 GC04U900479 GC04P089513 GC04P085266


Summaries
for HERC3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HERC3:
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds
ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by
RefSeq, Oct 2012)

UniProtKB/Swiss-Prot: HERC3_HUMAN, Q15034
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
thioester and then directly transfers the ubiquitin to targeted substrates (By similarity)




Genomic Views
for HERC3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HERC3 gene promoter:
         p53   Brachyury   POU6F1 (c2)   POU3F2   FOXL1   AREB6   MEF-2A   FOXO4   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HERC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HERC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HERC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21

HERC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HERC3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P089444:  view genomic region     (about GC identifiers)

Start:
 89,444,961 bp from pter      End:
 89,629,693 bp from pter
Size:
 184,733 bases      Orientation:
 plus strand

Proteins
for HERC3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HERC3_HUMAN, Q15034 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase HERC3  
Size: 1050 amino acids; 117188 Da
Subcellular location: Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures
Sequence caution: Sequence=BAA04945.2; Type=Erroneous initiation;
Secondary accessions: A8K1S5

Explore the universe of human proteins at neXtProt for HERC3: NX_Q15034

Post-translational modifications:

  • Ubiquitinated; which promotes degradation by the proteasome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15034

    • 4/7 DME Specific Peptides for HERC3 (Q15034) (see all 7)
     NLLDLPKY  GGVFTFGAG  EETFCLNFTI  QVAAGGAHSF 

    HERC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258531.1  NP_055421.1  

    ENSEMBL proteins: 
     ENSP00000424786   ENSP00000385684   ENSP00000405863   ENSP00000410029   ENSP00000384005  
     ENSP00000389991   ENSP00000406210   ENSP00000421021   ENSP00000264345   ENSP00000441703  

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    OriGene Protein Over-expression Lysate: HERC3
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    Novus Biologicals HERC3 Protein
    Novus Biologicals HERC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HERC3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IDA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--


    HERC3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HERC3

    Protein Domains /
    Families
    for HERC3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HERC3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009091 Reg_csome_cond/b-lactamase_inh
     IPR000569 HECT
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry Q15034

    ProtoNet protein and cluster: Q15034

    2 Blocks protein families:
    IPB000408 Regulator of chromosome condensation
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: HERC3_HUMAN, Q15034
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 7 RCC1 repeats


    Function
    for HERC3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HERC3_HUMAN, Q15034
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
    thioester and then directly transfers the ubiquitin to targeted substrates (By similarity)

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HERC3
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate HERC3 (see all 45):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-25 hsa-miR-30d hsa-miR-3138 hsa-miR-519a hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HERC3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HERC3 (see all 7)
    OriGene shRNA RFP: HERC3
    OriGene siRNA: HERC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HERC3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HERC3

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HERC3 

    Cell Line
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    Search LifeMap BioReagents cell lines for HERC3

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IBA--
    GO:0016881acid-amino acid ligase activity ----


    HERC3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HERC3:
     Decreased mitotic index  Increased cilium length after  

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Herc3):
     growth/size  integument 

    HERC3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HERC3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Ubiquitin mediated proteolysis0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for HERC3):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: HERC3_HUMAN, Q15034
    Pathway: Protein modification; protein ubiquitination


    HERC3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HERC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for HERC3 (Q150342, 3 ENSP000002643454) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TK1P041832, 3MINT-8273521 I2D: score=2 
    NME2P223923, ENSP000003655724I2D: score=1 STRING: ENSP00000365572
    UBCP0CG482, 3, ENSP000003448184MINT-13794 I2D: score=2 STRING: ENSP00000344818
    HERC6Q8IVU33, ENSP000002643464I2D: score=3 STRING: ENSP00000264346
    UBQLN1Q9UMX03, ENSP000003655764I2D: score=3 STRING: ENSP00000365576
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--


    HERC3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HERC3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HERC3

    4 HMDB Compounds for HERC3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about HERC3 

    Transcripts
    for HERC3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HERC3 gene (2 alternative transcripts): 
    NM_001271602.1  NM_014606.2  

    Unigene Cluster for HERC3:

    HECT and RLD domain containing E3 ubiquitin protein ligase 3
    Hs.35804  [show with all ESTs]
    Unigene Representative Sequence: NM_014606
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513325 ENST00000402738(uc003hrw.1 uc011cdn.1) ENST00000431413
    ENST00000422770 ENST00000407637(uc003hrv.3) ENST00000426683 ENST00000452979
    ENST00000470815 ENST00000504994 ENST00000512194 ENST00000264345(uc011cdo.1)
    ENST00000543130

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HERC3
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate HERC3 (see all 45):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-25 hsa-miR-30d hsa-miR-3138 hsa-miR-519a hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HERC3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HERC3 (see all 7)
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HERC3 (NM_014606)
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    Primer
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    Additional cDNA sequence: 

    AK289990.1 AK296379.1 AK296397.1 BC038960.1 D25215.1 

    11 DOTS entries:

    DT.100021784  DT.413340  DT.121250633  DT.97839295  DT.121250636  DT.121250677  DT.121250601  DT.413341 
    DT.91741906  DT.95166582  DT.97787072 

    GeneLoc Exon Structure


    Expression
    for HERC3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HERC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HERC3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HERC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HERC3

    SOURCE GeneReport for Unigene cluster: Hs.35804
        SABiosciences Expression via Pathway-Focused PCR Array including HERC3: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for HERC3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HERC3 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HERC31 hect domain and RLD 3 79.62(n)
    87.71(a)    		   422514  NM_001039298.1  NP_001034387.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HERC36
    		 --
    		 85(a)
    		 1 ↔ 1
    		 5(45848016-45878163)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.165372 Transcribed sequence with moderate similarity to protein more 76.88(n)    BI709406.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG91533 ubiquitin-protein ligase 44(a)   61F6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y48G8AL.13
    herc-11    		 Protein HERC-11 33(a)3
    47.18(n)1
    36.56(a)1    		   I(1211497-1254500)3
    1717001  NM_058433.21  NP_490834.11 


    ENSEMBL Gene Tree for HERC3 (if available)
    TreeFam Gene Tree for HERC3 (if available) 

    Paralogs
    for HERC3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HERC3 gene
    HERC12  HECTD22  HECTD32  HERC22  RCCD12  HERC62  HERC42  UBE3A2  
    HERC52  
    18 SIMAP similar genes for HERC3 using alignment to 10 protein entries:     HERC3_HUMAN (see all proteins):
    DKFZp564G092    HERC4    UBE3A    HECTD2    HERC6    HERC5
    MYCBP2    HERC1    HERC2    IBTK    WWP2    DKFZp564H223
    SMURF2    HUWE1    SERGEF    RCC1    WBSCR16    KIAA0317

    HERC3 for paralogs           About GeneDecksing



    Genomic Variants
    for HERC3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for HERC3
         1 CNV: 98791
         4 Indels: 46714 46713 12485 42200
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HERC3
    DNA2.0 Custom Variant and Variant Library Synthesis for HERC3

    Disorders / Diseases
    for HERC3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HERC3 for disorders           About GeneDecksing

    OMIM gene information: 605200    OMIM disorders: --

    1 disease for HERC3:    About MalaCards
    malaria

    Human Genome Epidemiology (HuGE) Navigator: HERC3 (1 document)

    Export disorders for HERC3 gene to outside databases

    Publications
    for HERC3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HERC3 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with HERC3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HERC3 binding to and regulation by ubiquitin. (PubMed id 11163799)1, 2 Cruz C.... Rosa J.L. (2001)
    2. The human HERC3 gene maps to chromosome 4q21 by fluorescence in situ hybridization. (PubMed id 10702688)1, 3 Cruz C....Rosa J.L. (1999)
    3. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Frameshift mutations of ubiquitination-related genes H ERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability. (PubMed id 22124266)1 Yoo N.J....Lee S.H. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for HERC3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing HERC3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8916 HGNC: 4876 Ensembl:ENSG00000138641 euGenes: HUgn8916 ECgene: HERC3 Kegg: 8916
    H-InvDB: HERC3

    Other Databases showing HERC3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0032

    Specialized Databases showing HERC3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HERC3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for HERC3 gene:
    Search GeneIP for patents involving HERC3

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