HERC2P3 Gene
pseudogene GIFtS: 33
GCID: GC15M020589
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hect domain and RLD 2 pseudogene 3
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Aliases
for HERC2P3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Hect Domain And RLD 2 Pseudogene 31 2 | | D15F37S41 2 | | LOC2837551 |
| External Ids: | HGNC: 48711 | Entrez Gene: 2837552 | Ensembl: ENSG000001802297 | UniProtKB: Q9BVR03 | | ORGUL members: | |
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| NONCODE:n410005 n386099 n346039 n346336 | |
Export aliases for HERC2P3 gene to outside databasesPrevious GC identifers: GC15U990059 GC15M018849
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Summaries
for HERC2P3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HERC2P3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_037852.6
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for HERC2P3
Other transcription factors
Search SABiosciences Chromatin IP Primers for HERC2P3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HERC2P3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q11.1 Ensembl cytogenetic band: 15q11.2 HGNC cytogenetic band: 15q11.2HERC2P3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M020589: view genomic region
(about GC identifiers)
Start:
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20,587,869 bp from pter |
End:
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20,711,433 bp from pter |
Size:
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123,565 bases |
Orientation:
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minus strand |
ORGUL member locations:
Legend (see complete legend)
- n410005
- n346039
- n346336
- n386099
20613649 20662541 20711433 chr15
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Proteins
for HERC2P3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HRC23_HUMAN, Q9BVR0 (See
protein sequence)Recommended Name: Putative HERC2-like protein 3 Size: 1158 amino acids; 128943 Da
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for HERC2P3: NX_Q9BVR0
HERC2P3 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
HERC2P3 Antibody Products:
Assay Products for HERC2P3: |
Protein
Domains /
Families
for HERC2P3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HERC2P3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BVR0ProtoNet protein and cluster: Q9BVR0 UniProtKB/Swiss-Prot: HRC23_HUMAN, Q9BVR0Similarity: Contains 1 MIB/HERC2 domain |
Function
for HERC2P3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for HERC2P3:HECT domain and RLD2,pseudogene 3
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERC2P3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
HERC2P3 for ontologies About GeneDecksing
|
Pathways & Interactions
for HERC2P3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HERC2P3
|
Drugs & Compounds
for HERC2P3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HERC2P3
Search CenterWatch for drugs/clinical trials and news about HERC2P3 
|
Transcripts
for HERC2P3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HERC2P3 gene: NM_001024682.1 Unigene Cluster for HERC2P3: Hect domain and RLD 2 pseudogene 3 Hs.608918 [show with all ESTs]Unigene Representative Sequence: BC03388816 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426501 ENST00000428453(uc001ytg.3) ENST00000437318(uc010tyx.1)
ENST00000430598(uc001yth.4) ENST00000429257 ENST00000424611 ENST00000454045
ENST00000436934 ENST00000440441 ENST00000440774 ENST00000429926 ENST00000456027
ENST00000414804 ENST00000412154 ENST00000545640(uc010tyy.2 uc010tyz.1)
ENST00000544900
Additional cDNA sequence: AK294470.1 AK294795.1 BC000975.2 BC033888.1 BC094757.1 BC144698.1 NR_036432.1 X69636.1 24/28 DOTS entries (see all 28): DT.102840141 DT.75182545 DT.121078929 DT.121078918 DT.121067087 DT.121078941 DT.100824634 DT.95259121 DT.121067241 DT.121014310 DT.121067076 DT.95259149 DT.121078914 DT.121078926 DT.100037793 DT.102845477 DT.121078899 DT.121078933 DT.121078940 DT.40206807 DT.70101511 DT.95337279 DT.100673996 DT.121014484 24/68 AceView cDNA sequences (see all 68): CA393097 CD722532 AU124754 BC070076 BC000975 BV193326 AA332456 BF507782 BG388015 AA757355 BV198625 BM786540 BX495751 BV192008 CA426342 BP348597 BV176030 BV198475 BM011742 BV176429 N69360 BV183738 BF510943 AI985804
GeneLoc Exon Structure
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Expression
for HERC2P3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HERC2P3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTTCTTTA
About this image
Genevestigator expression for HERC2P3
SOURCE GeneReport for Unigene cluster: Hs.608918
SABiosciences Custom PCR Arrays for HERC2P3
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HERC2P3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HERC2P3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HERC2P3 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HERC2P3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERC2P3 |
Orthologs
for HERC2P3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for HERC2P3 (if available)
TreeFam Gene Tree for HERC2P3 (if available) |
Paralogs
for HERC2P3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HERC2P3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HERC2P3 (20587869 - 20711433 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HERC2P3: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for HERC2P3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HERC2P3 for disorders About GeneDecksing
1  disease for HERC2P3: About MalaCardsangelman syndrome
Export disorders for HERC2P3 gene to outside databases
|
Publications
for HERC2P3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HERC2P3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HERC2P3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expressed copies of the MN7 (D15F37) gene family map close to the common deletion breakpoints in the Prader-Willi/Angelman syndromes. (PubMed id 9730612)1, 3 Buiting K....Horsthemke B. (1998)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The ancestral gene for transcribed, low-copy repeats in the Prader- Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities. (PubMed id 9949213)1 Ji Y.... Nicholls R.D. (1999)
- A putative gene family in 15q11-13 and 16p11.2: possible implications for Prader-Willi and Angelman syndromes. (PubMed id 1608955)1 Buiting K....Horsthemke B. (1992)
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External Searches for HERC2P3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HERC2P3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HERC2P3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HERC2P3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HERC2P3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HERC2P3 gene:
Search GeneIP for patents involving HERC2P3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HERC2P3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HERC2P3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HERC2P3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HERC2P3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HERC2P3 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HERC2P3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HERC2P3 |
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 |  |  |  | |
| | | | Search Tocris compounds for HERC2P3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HERC2P3 |
|  |  |  | | | | Search ThermoFisher Antibodies for HERC2P3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HERC2P3 |
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