Aliases for HERC2 Gene
- HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2 2 3 5
- HECT-Type E3 Ubiquitin Transferase HERC2 3 4
- Hect Domain And RLD 2 2 3
- Hect Domain And RCC1-Like Domain-Containing Protein 2 3
- HECT Domain And RCC1-Like Domain-Containing Protein 2 4
- Probable E3 Ubiquitin-Protein Ligase HERC2 3
- E3 Ubiquitin-Protein Ligase HERC2 3
- EC 22.214.171.124 4
External Ids for HERC2 Gene
Previous GeneCards Identifiers for HERC2 Gene
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
GeneCards Summary for HERC2 Gene
HERC2 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with HERC2 include Mental Retardation, Autosomal Recessive 38. Among its related pathways are DNA Double-Strand Break Repair and Innate Immune System. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is HERC1.
UniProtKB/Swiss-Prot for HERC2 Gene
E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of Lys-63-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.