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Aliases for HERC2 Gene

Aliases for HERC2 Gene

  • HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2 2 3 5
  • HECT-Type E3 Ubiquitin Transferase HERC2 3 4
  • Hect Domain And RLD 2 2 3
  • Hect Domain And RCC1-Like Domain-Containing Protein 2 3
  • HECT Domain And RCC1-Like Domain-Containing Protein 2 4
  • Probable E3 Ubiquitin-Protein Ligase HERC2 3
  • E3 Ubiquitin-Protein Ligase HERC2 3
  • EC 2.3.2.26 4
  • D15F37S1 3
  • EC 6.3.2 61
  • MRT38 3
  • SHEP1 3
  • Jdf2 3
  • P528 3

External Ids for HERC2 Gene

Previous GeneCards Identifiers for HERC2 Gene

  • GC15M024428
  • GC15M021248
  • GC15M025823
  • GC15M025958
  • GC15M026029
  • GC15M028356
  • GC15M006482

Summaries for HERC2 Gene

Entrez Gene Summary for HERC2 Gene

  • This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

GeneCards Summary for HERC2 Gene

HERC2 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with HERC2 include Mental Retardation, Autosomal Recessive 38. Among its related pathways are Immune System and DNA Double Strand Break Response. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is HERC1.

UniProtKB/Swiss-Prot for HERC2 Gene

  • E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of Lys-63-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.

Gene Wiki entry for HERC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERC2 Gene

Genomics for HERC2 Gene

Regulatory Elements for HERC2 Gene

Enhancers for HERC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F028106 0.8 Ensembl ENCODE 27.3 +214.9 214938 1.9 ZNF263 RNF2 CBX2 EZH2 HERC2 OCA2 GC15M028288
GH15F028293 0.8 ENCODE 26.6 +27.6 27619 2.3 HDAC1 LEF1 ESRRA TAL1 ZNF7 FOXK2 NCOR1 TRIM24 HES1 EGR2 HERC2 HERC2P9 GC15M028288 RPL41P2
GH15F028098 0.9 ENCODE 22.2 +223.2 223183 1.1 HDAC1 CBX3 RAD21 GLIS2 CREM KLF13 EGR2 ZNF263 SP3 ZEB2 HERC2 OCA2 GC15P028070
GH15F028135 0.6 Ensembl ENCODE 30 +185.3 185260 2.0 SPI1 HERC2 OCA2 LOC100419574 GC15M028288
GH15F028093 1.4 FANTOM5 Ensembl ENCODE 10.3 +226.4 226376 3.7 HDGF TBP ATF1 PKNOX1 ARID4B SIN3A GLIS2 KLF7 EGR2 SP3 HERC2 OCA2 GC15P028070
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HERC2 on UCSC Golden Path with GeneCards custom track

Promoters for HERC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001793242 272 2600 ZNF366 PRDM1

Genomic Location for HERC2 Gene

Chromosome:
15
Start:
28,111,037 bp from pter
End:
28,322,172 bp from pter
Size:
211,136 bases
Orientation:
Minus strand

Genomic View for HERC2 Gene

Genes around HERC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HERC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HERC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERC2 Gene

Proteins for HERC2 Gene

  • Protein details for HERC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95714-HERC2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HERC2
    Protein Accession:
    O95714
    Secondary Accessions:
    • Q86SV7
    • Q86SV8
    • Q86SV9
    • Q86YY3
    • Q86YY4
    • Q86YY5
    • Q86YY6
    • Q86YY7
    • Q86YY8
    • Q86YY9
    • Q86YZ0
    • Q86YZ1

    Protein attributes for HERC2 Gene

    Size:
    4834 amino acids
    Molecular mass:
    527228 Da
    Quaternary structure:
    • Interacts (when phosphorylated at Thr-4827 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionizing radiation (IR) treatment. Interacts with XPA. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97.
    Miscellaneous:
    • A regulatory element withinin an intron of the HERC2 gene inhibits OCA2 promoter. There are several single nucleotide polymorphisms within the OCA2 gene and within the HERC2 gene that have a statistical association with human eye color.

    Three dimensional structures from OCA and Proteopedia for HERC2 Gene

neXtProt entry for HERC2 Gene

Selected DME Specific Peptides for HERC2 Gene

O95714:
  • ACGSGDAQTL
  • GQVYAWG
  • ACGSSHS
  • GDGDYGKLG
  • GKLGRGGS
  • GELYTWG

Post-translational modifications for HERC2 Gene

  • Phosphorylation at Thr-4827 is required for interaction with RNF8.
  • Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs), promoting the interaction with RNF8.
  • Ubiquitination at Lys 20, Lys 95, Lys 105, Lys 990, Lys 2657, Lys 3690, Lys 3780, and Lys 3839
  • Modification sites at PhosphoSitePlus

Domains & Families for HERC2 Gene

Gene Families for HERC2 Gene

Suggested Antigen Peptide Sequences for HERC2 Gene

Graphical View of Domain Structure for InterPro Entry

O95714

UniProtKB/Swiss-Prot:

HERC2_HUMAN :
  • The ZZ-type zinc finger mediates binding to SUMO1, and at low level SUMO2.
  • Contains 21 RCC1 repeats.
Domain:
  • The ZZ-type zinc finger mediates binding to SUMO1, and at low level SUMO2.
  • The RCC1 repeats are grouped into three seven-bladed beta-propeller regions.
  • Contains 1 cytochrome b5 heme-binding domain.
  • Contains 1 DOC domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 1 MIB/HERC2 domain.
Similarity:
  • Contains 21 RCC1 repeats.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with HERC2: view

Function for HERC2 Gene

Molecular function for HERC2 Gene

GENATLAS Biochemistry:
HECT domain and RLD2,ancestral gene of a superfamily of low-copy repeat sequences in the PWCR/ANCR breakpoint cluster region
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of Lys-63-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.

Enzyme Numbers (IUBMB) for HERC2 Gene

Gene Ontology (GO) - Molecular Function for HERC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20304803
GO:0005085 guanyl-nucleotide exchange factor activity NAS 9949213
GO:0005515 protein binding IPI 20023648
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with HERC2: view
genes like me logo Genes that share phenotypes with HERC2: view

Human Phenotype Ontology for HERC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for HERC2 Gene

Localization for HERC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERC2 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HERC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HERC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20304803
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 20304803
GO:0005743 mitochondrial inner membrane IEA --
GO:0005814 centriole IEA --
genes like me logo Genes that share ontologies with HERC2: view

Pathways & Interactions for HERC2 Gene

genes like me logo Genes that share pathways with HERC2: view

UniProtKB/Swiss-Prot O95714-HERC2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for HERC2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HERC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006886 intracellular protein transport NAS 9949213
GO:0006974 cellular response to DNA damage stimulus IEA,IDA 22508508
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with HERC2: view

Drugs & Compounds for HERC2 Gene

(4) Drugs for HERC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
heme Pharma Agonist 0

(1) Additional Compounds for HERC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with HERC2: view

Transcripts for HERC2 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HERC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for HERC2 Gene

GeneLoc Exon Structure for
HERC2
ECgene alternative splicing isoforms for
HERC2

Expression for HERC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HERC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HERC2 Gene

This gene is overexpressed in Plasma (13.8), Stomach (11.9), Placenta (8.7), Testis (8.6), and Pancreatic juice (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HERC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of HERC2 Gene:

HERC2

SOURCE GeneReport for Unigene cluster for HERC2 Gene:

Hs.434890
genes like me logo Genes that share expression patterns with HERC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HERC2 Gene

Orthologs for HERC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HERC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HERC2 35
  • 100 (a)
OneToOne
LOC453257 34
  • 97.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HERC2 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HERC2 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HERC2 34 35
  • 89.73 (n)
cow
(Bos Taurus)
Mammalia HERC2 34 35
  • 88.86 (n)
mouse
(Mus musculus)
Mammalia Herc2 34 16 35
  • 87.33 (n)
rat
(Rattus norvegicus)
Mammalia Herc2 34
  • 87.31 (n)
chicken
(Gallus gallus)
Aves HERC2 34 35
  • 78.92 (n)
lizard
(Anolis carolinensis)
Reptilia HERC2 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia herc2 34
  • 75.21 (n)
zebrafish
(Danio rerio)
Actinopterygii herc2 34 35
  • 74.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta HERC2 36 34 35
  • 52.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011823 34
  • 32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAF1 37
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11556 34
Species where no ortholog for HERC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HERC2 Gene

ENSEMBL:
Gene Tree for HERC2 (if available)
TreeFam:
Gene Tree for HERC2 (if available)

Paralogs for HERC2 Gene

Variants for HERC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HERC2 Gene

HERC2_HUMAN-O95714
Genetic variants in HERC2 define the skin/hair/eye pigmentation variation locus 1 (SHEP1) [MIM:227220]; also known as skin/hair/eye pigmentation type 1, blue/nonblue eyes or skin/hair/eye pigmentation type 1, blue/brown eyes or skin/hair/eye pigmentation type 1, blond/brown hair or eye color, brown/blue or eye color, blue/nonblue or eye color type 3 (EYCL3) or brown eye color type 2 (BEY2) or hair color type 3 (HCL3). Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair.

Sequence variations from dbSNP and Humsavar for HERC2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs397518474 Mental retardation, autosomal recessive 38 (MRT38) [MIM:615516], Pathogenic 28,265,707(-) CATTC(C/T)GATGC intron-variant, nc-transcript-variant, reference, missense
rs146366728 Uncertain significance 28,198,757(+) TCTAA(C/T)CATCA nc-transcript-variant, reference, missense
rs200632307 Uncertain significance 28,255,999(+) AAACT(G/T)AAATA intron-variant
rs751891639 Uncertain significance 28,229,335(+) AATCA(A/C/G)TAAGA nc-transcript-variant, reference, missense
rs773700445 Uncertain significance 28,272,984(+) TGGTG(C/G)CTGGC intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HERC2 Gene

Variant ID Type Subtype PubMed ID
nsv984036 CNV duplication 23825009
nsv984035 CNV duplication 23825009
nsv977682 CNV duplication 23825009
nsv977679 CNV duplication 23825009
nsv976905 CNV duplication 23825009
nsv976904 CNV duplication 23825009
nsv976903 CNV duplication 23825009
nsv974539 CNV duplication 23825009
nsv974538 CNV duplication 23825009
nsv952579 CNV deletion 24416366
nsv9208 CNV gain+loss 18304495
nsv9207 CNV gain 18304495
nsv9206 CNV loss 18304495
nsv9205 CNV gain+loss 18304495
nsv568665 CNV loss 21841781
nsv568663 CNV loss 21841781
nsv568662 CNV gain 21841781
nsv469883 CNV gain 16826518
nsv433431 CNV gain 18776910
nsv428299 CNV loss 18775914
nsv1148560 OTHER inversion 26484159
nsv1138349 CNV deletion 24896259
nsv1113697 CNV deletion 24896259
nsv1052131 CNV gain 25217958
nsv1047941 CNV gain 25217958
nsv1039684 CNV gain 25217958
nsv1039547 CNV gain 25217958
nsv1038472 CNV gain 25217958
esv3892640 CNV gain 25118596
esv3635993 CNV gain 21293372
esv3635992 CNV gain 21293372
esv3635991 CNV gain 21293372
esv3635990 CNV gain 21293372
esv3635989 CNV loss 21293372
esv3635988 CNV gain 21293372
esv3569365 CNV gain 25503493
esv3451382 CNV duplication 20981092
esv3342263 CNV duplication 20981092
esv28855 CNV gain 19812545
esv2760021 CNV gain+loss 17122850
esv2674813 CNV deletion 23128226
esv2475219 CNV insertion 19546169
esv22824 CNV gain+loss 19812545
dgv2491n100 CNV gain 25217958
dgv2490n100 CNV gain 25217958
dgv2489n100 CNV gain 25217958
dgv1391e59 CNV duplication 20981092

Variation tolerance for HERC2 Gene

Residual Variation Intolerance Score: 0.163% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.57; 86.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HERC2 Gene

Human Gene Mutation Database (HGMD)
HERC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HERC2

Disorders for HERC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HERC2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 38
  • developmental delay with autism spectrum disorder and gait instability
- elite association - COSMIC cancer census association via MalaCards
Search HERC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HERC2_HUMAN
  • Mental retardation, autosomal recessive 38 (MRT38) [MIM:615516]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT38 is characterized by global developmental delay affecting motor, speech, adaptive, and social development. Patients manifest autistic features, aggression, self-injury, impulsivity, and distractibility. {ECO:0000269 PubMed:23065719}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HERC2

Genetic Association Database (GAD)
HERC2
Human Genome Epidemiology (HuGE) Navigator
HERC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HERC2
genes like me logo Genes that share disorders with HERC2: view

No data available for Genatlas for HERC2 Gene

Publications for HERC2 Gene

  1. Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. (PMID: 18252221) Kayser M. … van Duijn C.M. (Am. J. Hum. Genet. 2008) 3 4 46 64
  2. The ancestral gene for transcribed, low-copy repeats in the Prader- Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities. (PMID: 9949213) Ji Y. … Nicholls R.D. (Hum. Mol. Genet. 1999) 2 3 4 64
  3. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PMID: 22261722) Al-Hakim A.K. … Pelletier L. (Mol. Cell. Proteomics 2012) 3 4 64
  4. DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. (PMID: 22508508) Danielsen J.R. … Mailand N. (J. Cell Biol. 2012) 3 4 64
  5. A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder. (PMID: 23065719) Puffenberger E.G. … Strauss K.A. (Hum. Mutat. 2012) 3 4 64

Products for HERC2 Gene

Sources for HERC2 Gene

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