Aliases for HERC1 Gene
Aliases for HERC1 Gene
- HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 1 2 3 5
- Hect (Homologous To The E6-AP (UBE3A) Carboxyl Terminus) Domain And RCC1 (CHC1)-Like Domain (RLD) 1 2 3
- HECT Domain And RCC1-Like Domain-Containing Protein 1 3 4
- HECT-Type E3 Ubiquitin Transferase HERC1 3 4
- P532 3 4
- P619 3 4
External Ids for HERC1 Gene
- HGNC: 4867
- Entrez Gene: 8925
- Ensembl: ENSG00000103657
- OMIM: 605109
- UniProtKB: Q15751
Previous GeneCards Identifiers for HERC1 Gene
- GC15M059686
- GC15M057058
- GC15M061479
- GC15M061616
- GC15M061687
- GC15M063900
- GC15M040725
Summaries for HERC1 Gene
-
This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
GeneCards Summary for HERC1 Gene
HERC1 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 1) is a Protein Coding gene. Diseases associated with HERC1 include Macrocephaly, Dysmorphic Facies, And Psychomotor Retardation and Megalencephaly-Severe Kyphoscoliosis-Overgrowth Syndrome. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include binding and ubiquitin-protein transferase activity. An important paralog of this gene is HERC2.
UniProtKB/Swiss-Prot for HERC1 Gene
-
Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERC1 Gene
Genomics for HERC1 Gene
Regulatory Elements for HERC1 Gene
Enhancers for HERC1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HERC1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HERC1 gene promoter:
Regulatory Element Products
Genomic Location for HERC1 Gene
- Chromosome:
- 15
- Start:
- 63,608,618 bp from pter
- End:
- 63,833,949 bp from pter
- Size:
- 225,332 bases
- Orientation:
- Minus strand
Genomic View for HERC1 Gene
Genes around HERC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.31 by Ensembl
- 15q22.31 by Entrez Gene
- 15q22.31 by HGNC
HERC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HERC1 Gene
Proteins for HERC1 Gene
-
Protein details for HERC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15751-HERC1_HUMAN
- Recommended name:
- Probable E3 ubiquitin-protein ligase HERC1
- Protein Accession:
- Q15751
- Q8IW65
Protein attributes for HERC1 Gene
- Size:
- 4861 amino acids
- Molecular mass:
- 532228 Da
- Quaternary structure:
-
- Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A.
Protein Expression for HERC1 Gene
Selected DME Specific Peptides for HERC1 Gene
- Q15751:
-
- GQVYAWG
- GDGDYGKLG
- GELYTWG
Post-translational modifications for HERC1 Gene
Other Protein References for HERC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HERC1
-
Abcam antibodies for HERC1
- Invitrogen Antibodies for HERC1
- antibodies-online Antibodies for HERC1: See all 15
- Search GeneTex for Antibodies for HERC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HERC1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HERC1
- Origene Custom Protein Services for HERC1
- Novus Biologicals proteins for HERC1
- Search GeneTex for Proteins for HERC1
Assay Products
Domains & Families for HERC1 Gene
Gene Families for HERC1 Gene
Protein Domains for HERC1 Gene
Suggested Antigen Peptide Sequences for HERC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HERC1 Gene
Function for HERC1 Gene
Molecular function for HERC1 Gene
- GENATLAS Biochemistry:
- HECT (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD)1,ubiquitously expressed,located in the cytosol in the Golgi apparatus,stimulating guanine nucleotide,forming a cytosolic ternary complex with clathrin and Hsp70,involved in protein trafficking
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Enzyme Numbers (IUBMB) for HERC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | TAS | 8861955 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for HERC1 Gene
- MGI mutant phenotypes for HERC1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HERC1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Lamellipodia cells
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased shRNA abundance (Z-score > 2)
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
-
Taconic Biosciences Mouse Models for HERC1
-
ViGene Biosciences lentiviral particle packaged cDNA for HERC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HERC1 gene
- Search ViGene Biosciences for HERC1
CRISPR Products
-
OriGene CRISPR knockouts for HERC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HERC1
- GenScript: Design CRISPR guide RNA sequences for HERC1
miRNA for HERC1 Gene
- miRTarBase miRNAs that target HERC1
miRNA Products
- Search ViGene Biosciences for HERC1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HERC1
- Browse OriGene Inhibitory RNA Products For HERC1
-
ViGene Biosciences ready-to-package AAV shRNAs for HERC1 gene
Cell Line Products
-
Horizon Cell Lines for HERC1
-
ViGene Biosciences adenoviral particle packaged cDNA for HERC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HERC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HERC1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HERC1 Gene
Localization for HERC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HERC1 Gene
- Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| golgi apparatus | 5 |
| plasma membrane | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 8861955 |
| GO:0005794 | Golgi apparatus | TAS,IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for HERC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Ubiquitin mediated proteolysis | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for HERC1 Gene
4 Reactome pathways for HERC1 Gene
1 KEGG pathway for HERC1 Gene
UniProtKB/Swiss-Prot Q15751-HERC1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for HERC1 Gene
Selected Interacting proteins:
ENSP00000390158
Q15751-HERC1_HUMAN
for HERC1 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0010507 | negative regulation of autophagy | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0021702 | cerebellar Purkinje cell differentiation | IEA | -- |
| GO:0031175 | neuron projection development | IEA | -- |
No data available for SIGNOR curated interactions for HERC1 Gene
Drugs & Compounds for HERC1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for HERC1 Gene
mRNA/cDNA for HERC1 Gene
- (9) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (231) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HERC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HERC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HERC1
- GenScript: Design CRISPR guide RNA sequences for HERC1
miRNA Products
- Search ViGene Biosciences for HERC1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HERC1
- Browse OriGene Inhibitory RNA Products For HERC1
-
ViGene Biosciences ready-to-package AAV shRNAs for HERC1 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: |
Expression for HERC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
- Primordial Germ Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
This gene is overexpressed in Bone marrow mesenchymal stem cell (51.4) and Cervix (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HERC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HERC1 Gene:
HERC1SOURCE GeneReport for Unigene cluster for HERC1 Gene:
Hs.210385mRNA Expression by UniProt/SwissProt for HERC1 Gene:
Q15751-HERC1_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for HERC1 Gene
- Liver(4.2)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for HERC1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HERC1 Gene
Orthologs for HERC1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HERC1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HERC1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HERC1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HERC1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HERC1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Herc1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Herc1 34 |
|
||
| chicken (Gallus gallus) |
Aves | HERC1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HERC1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | herc1 34 |
|
||
| Str.16459 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9584 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | HERC1 35 |
|
OneToOne | |
| LOC569603 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | HERC2 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for HERC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HERC1 Gene
(5) SIMAP similar genes for HERC1 Gene using alignment to 10 proteins:
Variants for HERC1 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_076995 | Macrocephaly, dysmorphic facies, and psychomotor retardation (MDFPMR) [MIM:617011] | ||||
| rs753780877 | Pathogenic | 63,656,210(+) | ACCTC(A/C/G)TGATC | reference, missense | |
| rs769677823 | Pathogenic | 63,623,777(+) | CAGCC(C/G/T)CTTCT | reference, missense | |
| rs797045141 | Pathogenic | 63,696,341(-) | CCTCA(A/C)GCTTC | splice-acceptor-variant | |
| rs879253786 | Pathogenic | 63,734,745(-) | AGATG(A/G)GAAAG | reference, stop-gained |
Residual Variation Intolerance Score:
0.0542% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.90;
93.54% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HERC1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HERC1 Gene
Disorders for HERC1 Gene
(5) MalaCards diseases for HERC1 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| macrocephaly, dysmorphic facies, and psychomotor retardation |
|
|
| megalencephaly-severe kyphoscoliosis-overgrowth syndrome |
|
|
| chromosome 1q41-q42 deletion syndrome |
|
|
| gestational choriocarcinoma |
|
|
| megalencephaly |
|
|
Search HERC1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HERC1_HUMAN- Macrocephaly, dysmorphic facies, and psychomotor retardation (MDFPMR) [MIM:617011]: An autosomal recessive syndrome characterized by large head and somatic overgrowth, intellectual disability, and facial dysmorphism. Seizures, hypotonia and ataxic gait are observed in some patients. {ECO:0000269 PubMed:26138117}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HERC1
No data available for Genatlas for HERC1 Gene
Publications for HERC1 Gene
- A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. (PMID: 9233772) Rosa J.L. … Barbacid M. (Oncogene 1997) 2 3 4 22 64
- p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. (PMID: 8861955) Rosa J.L. … Barbacid M. (EMBO J. 1996) 2 3 4 22 64
- The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells. (PMID: 14960311) Garcia-Gonzalo F.R. … Rosa J.L. (FEBS Lett. 2004) 3 4 22 64
- Interaction between HERC1 and M2-type pyruvate kinase. (PMID: 12650930) Garcia-Gonzalo F.R. … Rosa J.L. (FEBS Lett. 2003) 3 4 22 64
- Biallelic HERC1 mutations in a syndromic form of overgrowth and intellectual disability. (PMID: 26138117) Ortega-Recalde O. … Laissue P. (Clin. Genet. 2015) 3 4 64
Products for HERC1 Gene
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- Novus Biologicals Antibodies for HERC1
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- Novus Biologicals
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- Taconic Biosciences Mouse Models for HERC1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for HERC1
- Addgene plasmids for HERC1
- Search GeneTex for Antibodies for HERC1
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- ViGene Biosciences adenoviral particle packaged cDNA for HERC1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HERC1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HERC1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for HERC1
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- Cyagen custom Knockout/knockin (KOKI) mouse models for HERC1
- VectorBuilder custom plasmid, inducible vectors for HERC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HERC1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HERC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
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