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Aliases for HEPN1 Gene

Aliases for HEPN1 Gene

  • Hepatocellular Carcinoma, Down-Regulated 1 2 3 5
  • Cancer Susceptibility Gene HEPN1 2
  • HEPACAM Opposite Strand 1 2

External Ids for HEPN1 Gene

Previous GeneCards Identifiers for HEPN1 Gene

  • GC11U900685
  • GC11P124294
  • GC11P124789
  • GC11P120731

Summaries for HEPN1 Gene

Entrez Gene Summary for HEPN1 Gene

  • This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354). [provided by RefSeq, Aug 2011]

GeneCards Summary for HEPN1 Gene

HEPN1 (Hepatocellular Carcinoma, Down-Regulated 1) is a Protein Coding gene. Diseases associated with HEPN1 include hepatocellular carcinoma.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEPN1 Gene

Genomics for HEPN1 Gene

Regulatory Elements for HEPN1 Gene

Enhancers for HEPN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HEPN1 on UCSC Golden Path with GeneCards custom track

Promoters for HEPN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HEPN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HEPN1 Gene

Chromosome:
11
Start:
124,919,244 bp from pter
End:
124,920,677 bp from pter
Size:
1,434 bases
Orientation:
Plus strand

Genomic View for HEPN1 Gene

Genes around HEPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEPN1 Gene

Proteins for HEPN1 Gene

  • Protein details for HEPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WQI6-HEPN1_HUMAN
    Recommended name:
    Putative cancer susceptibility gene HEPN1 protein
    Protein Accession:
    Q6WQI6

    Protein attributes for HEPN1 Gene

    Size:
    88 amino acids
    Molecular mass:
    10305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HEPN1 Gene

Proteomics data for HEPN1 Gene at MOPED

Post-translational modifications for HEPN1 Gene

No Post-translational modifications

Other Protein References for HEPN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEPN1 Gene

Domains & Families for HEPN1 Gene

Protein Domains for HEPN1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HEPN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HEPN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HEPN1 Gene

Function for HEPN1 Gene

Phenotypes for HEPN1 Gene

genes like me logo Genes that share phenotypes with HEPN1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEPN1 Gene

Localization for HEPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEPN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEPN1 Gene COMPARTMENTS Subcellular localization image for HEPN1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for HEPN1 Gene

Pathways & Interactions for HEPN1 Gene

SuperPathways for HEPN1 Gene

No Data Available

Interacting Proteins for HEPN1 Gene

Gene Ontology (GO) - Biological Process for HEPN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HEPN1 Gene

Drugs & Compounds for HEPN1 Gene

No Compound Related Data Available

Transcripts for HEPN1 Gene

mRNA/cDNA for HEPN1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HEPN1 Gene

Hepatocellular carcinoma, down-regulated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HEPN1 Gene

No ASD Table

Relevant External Links for HEPN1 Gene

GeneLoc Exon Structure for
HEPN1
ECgene alternative splicing isoforms for
HEPN1

Expression for HEPN1 Gene

mRNA expression in normal human tissues for HEPN1 Gene

mRNA expression in normal human tissues for HEPN1 Gene

SOURCE GeneReport for Unigene cluster for HEPN1 Gene Hs.159863

mRNA Expression by UniProt/SwissProt for HEPN1 Gene

Q6WQI6-HEPN1_HUMAN
Tissue specificity: Expressed in liver. Expression is either down-regulated or lost in hepatocellular carcinomas (HCC).
genes like me logo Genes that share expression patterns with HEPN1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HEPN1 Gene

Orthologs for HEPN1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HEPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEPN1 35
  • 99.24 (n)
  • 97.73 (a)
HEPN1 36
  • 98 (a)
OneToOne
Species with no ortholog for HEPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HEPN1 Gene

ENSEMBL:
Gene Tree for HEPN1 (if available)
TreeFam:
Gene Tree for HEPN1 (if available)

Paralogs for HEPN1 Gene

No data available for Paralogs for HEPN1 Gene

Variants for HEPN1 Gene

Sequence variations from dbSNP and Humsavar for HEPN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_051027 -
rs61336045 -- 124,918,342(+) TAGTC(C/T)CAAGT upstream-variant-2KB
rs11822898 -- 124,917,633(+) gctgc(C/T)gggtg upstream-variant-2KB
rs71478456 -- 124,918,258(+) CATCT(-/T)CTTGA upstream-variant-2KB
rs190670220 -- 124,917,467(+) TCTGG(C/T)GAGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HEPN1 Gene

Variant ID Type Subtype PubMed ID
esv2745189 CNV Deletion 23290073

Variation tolerance for HEPN1 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HEPN1 Gene

HapMap Linkage Disequilibrium report
HEPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEPN1 Gene

Disorders for HEPN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HEPN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search HEPN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HEPN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEPN1
genes like me logo Genes that share disorders with HEPN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HEPN1 Gene

Publications for HEPN1 Gene

  1. HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells. (PMID: 12971969) Moh M.C. … Shen S. (J. Hepatol. 2003) 2 3 4 67
  2. Silencing of HEPN1 is responsible for the aggressive biological behavior of pituitary somatotroph adenomas. (PMID: 23548416) Peng H. … Liao J. (Cell. Physiol. Biochem. 2013) 2 3
  3. MicroRNA-21 promotes cell proliferation in human hepatocellular carcinoma partly by targeting HEPN1. (PMID: 25687183) Hu S. … Gao Y. (Tumour Biol. 2015) 3
  4. Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor. (PMID: 25448679) Kim H.S. … Jung G. (FEBS Lett. 2014) 3
  5. Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma. (PMID: 15885354) Moh M.C. … Shen S. (J. Hepatol. 2005) 3

Products for HEPN1 Gene

Sources for HEPN1 Gene

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