HEPN1 Gene
protein-coding GIFtS: 29
GCID: GC11P124789
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hepatocellular carcinoma, down-regulated 1(Previous name: HEPACAM opposite strand 1 )
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Aliases
for HEPN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Hepatocellular Carcinoma, Down-Regulated 11 2 | | HEPACAM Opposite Strand 11 2 | | Cancer Susceptibility Gene HEPN12 | | Putative Cancer Susceptibility Gene HEPN1 Protein2 |
Export aliases for HEPN1 gene to outside databasesPrevious GC identifers: GC11U900685 GC11P124294 GC11P120731 |
Summaries
for HEPN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HEPN1:
This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm.Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it mayhave a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC),suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is thatthis gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354).(provided by RefSeq, Aug 2011)
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Genomic Views
for HEPN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HEPN1 gene promoter:
TBP Egr-3 ISGF-3 CUTL1 GATA-1 PPAR-gamma1 POU2F1a TFIID FOXO4 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HEPN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEPN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q24 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24HEPN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P124789: view genomic region
(about GC identifiers)
Start:
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124,789,140 bp from pter |
End:
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124,790,573 bp from pter |
Size:
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1,434 bases |
Orientation:
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plus strand |
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Proteins
for HEPN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HEPN1_HUMAN, Q6WQI6 (See
protein sequence)Recommended Name: Putative cancer susceptibility gene HEPN1 protein Size: 88 amino acids; 10305 Da
Subcellular location: Cytoplasm
Caution: Product of a dubious CDS prediction. Encoded by the 3'-UTR of HEPACAMExplore the universe of human proteins at neXtProt for HEPN1: NX_Q6WQI6
HEPN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001032647.2
ENSEMBL proteins: ENSP00000386143
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
IEA | -- |
HEPN1 for ontologies About GeneDecksing
HEPN1 Antibody Products:
Assay Products for HEPN1: |
Protein
Domains /
Families
for HEPN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6WQI6 |
Function
for HEPN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEPN1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEPN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HEPN1 (NM_001037558) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HEPN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEPN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEPN1 |
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Pathways & Interactions
for HEPN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HEPN1
|
Drugs & Compounds
for HEPN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HEPN1
Search CenterWatch for drugs/clinical trials and news about HEPN1
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Transcripts
for HEPN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HEPN1 gene: NM_001037558.2 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000408930(uc001qbj.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEPN1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEPN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HEPN1 (NM_001037558) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HEPN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEPN1 |
GeneLoc Exon Structure
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Expression
for HEPN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HEPN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HEPN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HEPN1
UniProtKB/Swiss-Prot: HEPN1_HUMAN, Q6WQI6Tissue specificity: Expressed in liver. Expression is either down-regulated or lost in hepatocellular carcinomas (HCC)
SABiosciences Custom PCR Arrays for HEPN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEPN1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HEPN1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEPN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEPN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEPN1 |
Orthologs
for HEPN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for HEPN1 (if available)
TreeFam Gene Tree for HEPN1 (if available) |
Paralogs
for HEPN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HEPN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for HEPN1 (124789140 - 124790573 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HEPN1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEPN1 |
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Disorders
/ Diseases
for HEPN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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HEPN1 for disorders About GeneDecksing
OMIM gene information: 611641
OMIM disorders: --
3  diseases for HEPN1: About MalaCardshepatocellular carcinoma carcinoma breast carcinoma
Export disorders for HEPN1 gene to outside databases
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Publications
for HEPN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HEPN1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HEPN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells. (PubMed id 12971969)1, 2, 3 Moh M.C.... Shen S. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma. (PubMed id 15885354)1 Moh M.C.... Shen S. (2005)
- Structural and functional analyses of a novel ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells. (PubMed id 15917256)1 Moh M.C....Shen S. (2005)
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External Searches for HEPN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HEPN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HEPN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HEPN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HEPN1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HEPN1 gene:
Search GeneIP for patents involving HEPN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HEPN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HEPN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HEPN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HEPN1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HEPN1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HEPN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HEPN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HEPN1 | | OriGene Custom Protein Services for HEPN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HEPN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEPN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEPN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HEPN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HEPN1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HEPN1 |
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| | | | Search Tocris compounds for HEPN1 |
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 | | | HEPN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEPN1 |
|  |  |  | | | | ThermoFisher Antibodies for HEPN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEPN1 |
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