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Aliases for HEPACAM2 Gene

Aliases for HEPACAM2 Gene

  • HEPACAM Family Member 2 2 3 5
  • Mitotic Kinetics Regulator 3 4
  • MIKI 3 4

External Ids for HEPACAM2 Gene

Previous GeneCards Identifiers for HEPACAM2 Gene

  • GC07M092656
  • GC07M092817
  • GC07M087426

Summaries for HEPACAM2 Gene

GeneCards Summary for HEPACAM2 Gene

HEPACAM2 (HEPACAM Family Member 2) is a Protein Coding gene. An important paralog of this gene is HEPACAM.

UniProtKB/Swiss-Prot for HEPACAM2 Gene

  • Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEPACAM2 Gene

Genomics for HEPACAM2 Gene

Regulatory Elements for HEPACAM2 Gene

Enhancers for HEPACAM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HEPACAM2 on UCSC Golden Path with GeneCards custom track

Promoters for HEPACAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HEPACAM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HEPACAM2 Gene

Chromosome:
7
Start:
93,188,586 bp from pter
End:
93,232,297 bp from pter
Size:
43,712 bases
Orientation:
Minus strand

Genomic View for HEPACAM2 Gene

Genes around HEPACAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEPACAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEPACAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEPACAM2 Gene

Proteins for HEPACAM2 Gene

  • Protein details for HEPACAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MVW5-HECA2_HUMAN
    Recommended name:
    HEPACAM family member 2
    Protein Accession:
    A8MVW5
    Secondary Accessions:
    • B3KTT4
    • B4DPJ1
    • B9EG93
    • E9PDV5
    • Q6UXI0

    Protein attributes for HEPACAM2 Gene

    Size:
    462 amino acids
    Molecular mass:
    51407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HEPACAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HEPACAM2 Gene

Proteomics data for HEPACAM2 Gene at MOPED

Post-translational modifications for HEPACAM2 Gene

  • N-glycosylated.
  • Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes.
  • Glycosylation at Asn 85, Asn 129, Asn 165, Asn 216, Asn 288, and Asn 320
  • Modification sites at PhosphoSitePlus

Other Protein References for HEPACAM2 Gene

Antibody Products

No data available for DME Specific Peptides for HEPACAM2 Gene

Domains & Families for HEPACAM2 Gene

Protein Domains for HEPACAM2 Gene

Suggested Antigen Peptide Sequences for HEPACAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MVW5

UniProtKB/Swiss-Prot:

HECA2_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with HEPACAM2: view

Function for HEPACAM2 Gene

Molecular function for HEPACAM2 Gene

UniProtKB/Swiss-Prot Function:
Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.
genes like me logo Genes that share phenotypes with HEPACAM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HEPACAM2

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEPACAM2 Gene

Localization for HEPACAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEPACAM2 Gene

Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation). {ECO:0000269 PubMed:19358830, ECO:0000269 PubMed:22864114}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEPACAM2 Gene COMPARTMENTS Subcellular localization image for HEPACAM2 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
plasma membrane 3
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HEPACAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005813 centrosome IDA 22864114
GO:0005819 spindle IDA 22864114
genes like me logo Genes that share ontologies with HEPACAM2: view

Pathways & Interactions for HEPACAM2 Gene

SuperPathways for HEPACAM2 Gene

No Data Available

Interacting Proteins for HEPACAM2 Gene

Gene Ontology (GO) - Biological Process for HEPACAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HEPACAM2: view

No data available for Pathways by source and SIGNOR curated interactions for HEPACAM2 Gene

Drugs & Compounds for HEPACAM2 Gene

No Compound Related Data Available

Transcripts for HEPACAM2 Gene

Unigene Clusters for HEPACAM2 Gene

HEPACAM family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HEPACAM2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:

Relevant External Links for HEPACAM2 Gene

GeneLoc Exon Structure for
HEPACAM2
ECgene alternative splicing isoforms for
HEPACAM2

Expression for HEPACAM2 Gene

mRNA expression in normal human tissues for HEPACAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEPACAM2 Gene

This gene is overexpressed in Colon - Transverse (x22.6), Small Intestine - Terminal Ileum (x9.0), Pituitary (x5.7), and Kidney - Cortex (x5.0).

SOURCE GeneReport for Unigene cluster for HEPACAM2 Gene Hs.443169

mRNA Expression by UniProt/SwissProt for HEPACAM2 Gene

A8MVW5-HECA2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with HEPACAM2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HEPACAM2 Gene

Orthologs for HEPACAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEPACAM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HEPACAM2 35
  • 88.99 (n)
  • 90.6 (a)
HEPACAM2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEPACAM2 35
  • 89.58 (n)
  • 90.62 (a)
HEPACAM2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hepacam2 35
  • 85.28 (n)
  • 85.5 (a)
Hepacam2 16
Hepacam2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HEPACAM2 35
  • 99.71 (n)
  • 99.57 (a)
HEPACAM2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hepacam2 35
  • 84.05 (n)
  • 85.06 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HEPACAM2 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves HEPACAM2 35
  • 71.51 (n)
  • 68.94 (a)
HEPACAM2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEPACAM2 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hepacam2 35
  • 65.5 (n)
  • 59.91 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC558612 35
  • 48.53 (n)
  • 37.87 (a)
hepacam2 36
  • 35 (a)
OneToOne
Species with no ortholog for HEPACAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEPACAM2 Gene

ENSEMBL:
Gene Tree for HEPACAM2 (if available)
TreeFam:
Gene Tree for HEPACAM2 (if available)

Paralogs for HEPACAM2 Gene

Paralogs for HEPACAM2 Gene

genes like me logo Genes that share paralogs with HEPACAM2: view

Variants for HEPACAM2 Gene

Sequence variations from dbSNP and Humsavar for HEPACAM2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_042976 A breast cancer sample
rs10281525 - 93,219,274(+) CAGAC(G/T)TATTC reference, missense
VAR_064721 -
rs6950913 -- 93,193,592(+) CAATA(C/G/T)GCCAA intron-variant
rs1079889 -- 93,208,517(-) CACTT(C/T)CCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEPACAM2 Gene

Variant ID Type Subtype PubMed ID
nsv528267 CNV Loss 19592680
esv2581618 CNV Deletion 19546169

Variation tolerance for HEPACAM2 Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HEPACAM2 Gene

HapMap Linkage Disequilibrium report
HEPACAM2
Human Gene Mutation Database (HGMD)
HEPACAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEPACAM2 Gene

Disorders for HEPACAM2 Gene

Relevant External Links for HEPACAM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEPACAM2

No disorders were found for HEPACAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEPACAM2 Gene

Publications for HEPACAM2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation. (PMID: 22864114) Ozaki Y. … Inaba T. (Mol. Cell 2012) 3
  4. Identification of a common microdeletion cluster in 7q21.3 subband among patients with myeloid leukemia and myelodysplastic syndrome. (PMID: 19358830) Asou H. … Inaba T. (Biochem. Biophys. Res. Commun. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for HEPACAM2 Gene

Sources for HEPACAM2 Gene

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