Aliases for HENMT1 Gene
Aliases for HENMT1 Gene
External Ids for HENMT1 Gene
- HGNC: 26400
- Entrez Gene: 113802
- Ensembl: ENSG00000162639
- OMIM: 612178
- UniProtKB: Q5T8I9
Previous HGNC Symbols for HENMT1 Gene
- C1orf59
Previous GeneCards Identifiers for HENMT1 Gene
- GC01M109191
Summaries for HENMT1 Gene
GeneCards Summary for HENMT1 Gene
HENMT1 (HEN Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.
UniProtKB/Swiss-Prot for HENMT1 Gene
-
Methyltransferase that adds a 2-O-methyl group at the 3-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HENMT1 Gene
Genomics for HENMT1 Gene
Regulatory Elements for HENMT1 Gene
Regulatory Element Products
Genomic Location for HENMT1 Gene
- Chromosome:
- 1
- Start:
- 108,648,288 bp from pter
- End:
- 108,661,526 bp from pter
- Size:
- 13,239 bases
- Orientation:
- Minus strand
Genomic View for HENMT1 Gene
- Cytogenetic band:
-
- 1p13.3 by Ensembl
- 1p13.3 by Entrez Gene
- 1p13.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HENMT1 Gene
Proteins for HENMT1 Gene
-
Protein details for HENMT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T8I9-HENMT_HUMAN
- Recommended name:
- Small RNA 2-O-methyltransferase
- Protein Accession:
- Q5T8I9
- A8MRR6
- B1AM16
- B1AM17
- Q96EJ7
- Q96NN0
Protein attributes for HENMT1 Gene
- Size:
- 393 amino acids
- Molecular mass:
- 44525 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAI12930.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for HENMT1 Gene
Post-translational modifications for HENMT1 Gene
Other Protein References for HENMT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HENMT1
- Novus Biologicals Antibodies for HENMT1
- Invitrogen Antibodies for HENMT1
- antibodies-online Antibodies for HENMT1: See all 18
- GeneTex HENMT1 antibody for HENMT1
Protein Products
-
OriGene Purified Proteins for HENMT1
- Search Origene for MassSpec and Protein Over-expression Lysates for HENMT1
- Origene Custom Protein Services for HENMT1
- antibodies-online Proteins for HENMT1: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HENMT1
Assay Products
No data available for DME Specific Peptides for HENMT1 Gene
Domains & Families for HENMT1 Gene
Gene Families for HENMT1 Gene
Protein Domains for HENMT1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HENMT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5T8I9- Family:
-
- Belongs to the methyltransferase superfamily. HEN1 family.
Function for HENMT1 Gene
Molecular function for HENMT1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3-terminal 2-O-methylnucleotide.
- UniProtKB/Swiss-Prot Function:
- Methyltransferase that adds a 2-O-methyl group at the 3-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
Enzyme Numbers (IUBMB) for HENMT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 22458338 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0008171 | O-methyltransferase activity | ISS | -- |
| GO:0008173 | RNA methyltransferase activity | ISS | -- |
Phenotypes for HENMT1 Gene
- GenomeRNAi human phenotypes for HENMT1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HENMT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HENMT1 gene
- Search ViGene Biosciences for HENMT1
CRISPR Products
-
OriGene CRISPR knockouts for HENMT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HENMT1
- GenScript: Design CRISPR guide RNA sequences for HENMT1
Transcription Factor Targets for HENMT1 Gene
miRNA Products
- Search ViGene Biosciences for HENMT1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HENMT1
- Browse OriGene Inhibitory RNA Products For HENMT1
-
ViGene Biosciences ready-to-package AAV shRNAs for HENMT1 gene
Cell Line Products
-
Horizon Cell Lines for HENMT1
-
ViGene Biosciences adenoviral particle packaged cDNA for HENMT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HENMT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HENMT1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for HENMT1 Gene
Localization for HENMT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HENMT1 Gene
- Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q568P9}.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0043186 | P granule | ISS | -- |
Pathways & Interactions for HENMT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Mitotic Prophase | ||
| 3 | PIWI-interacting RNA (piRNA) biogenesis | ||
Pathways by source for HENMT1 Gene
3 Reactome pathways for HENMT1 Gene
Interacting Proteins for HENMT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001510 | RNA methylation | ISS | -- |
| GO:0031047 | gene silencing by RNA | IEA | -- |
| GO:0032259 | methylation | IEA | -- |
| GO:0034587 | piRNA metabolic process | ISS | -- |
No data available for SIGNOR curated interactions for HENMT1 Gene
Transcripts for HENMT1 Gene
mRNA/cDNA for HENMT1 Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (125) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HENMT1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HENMT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HENMT1
- GenScript: Design CRISPR guide RNA sequences for HENMT1
miRNA Products
- Search ViGene Biosciences for HENMT1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HENMT1
- Browse OriGene Inhibitory RNA Products For HENMT1
-
ViGene Biosciences ready-to-package AAV shRNAs for HENMT1 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: |
Expression for HENMT1 Gene
mRNA differential expression in normal tissues according to GTEx for HENMT1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HENMT1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HENMT1 Gene:
HENMT1SOURCE GeneReport for Unigene cluster for HENMT1 Gene:
Hs.7962Evidence on tissue expression from TISSUES for HENMT1 Gene
- Nervous system(4.6)
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs for HENMT1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HENMT1 Gene
Orthologs for HENMT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HENMT1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Henmt1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Henmt1 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HENMT1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC479920 34 |
|
||
| HENMT1 35 |
|
OneToOne | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | HENMT1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HENMT1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HENMT1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | henmt1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | henmt1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Hen1 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | henn-1 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.976 35 |
|
OneToOne |
- Species where no ortholog for HENMT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HENMT1 Gene
No data available for Paralogs for HENMT1 Gene
Variants for HENMT1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000149852 | -- | 108,662,199(+) | GCTTC(C/G)GCCTG | intron-variant, upstream-variant-2KB | |
| rs1000233564 | -- | 108,657,756(+) | TCATG(-/T)TAAGC | intron-variant | |
| rs1000237633 | -- | 108,656,864(+) | CAAGA(G/T)CACAT | intron-variant | |
| rs1000663176 | -- | 108,661,670(+) | TGGCC(C/T)AGTGA | nc-transcript-variant, upstream-variant-2KB | |
| rs1000820354 | -- | 108,661,883(+) | AGGGG(G/T)GTGAG | intron-variant, upstream-variant-2KB |
Relevant External Links for HENMT1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HENMT1 Gene
Disorders for HENMT1 Gene
Relevant External Links for HENMT1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HENMT1
No disorders were found for HENMT1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HENMT1 Gene
Publications for HENMT1 Gene
- HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. (PMID: 26496356) Lim S.L. … O'Bryan M.K. (PLoS Genet. 2015) 2 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3 64
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
Products for HENMT1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HENMT1
- Search Origene for MassSpec and Protein Over-expression Lysates for HENMT1
- Origene Custom Protein Services for HENMT1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HENMT1
- Browse OriGene Inhibitory RNA Products For HENMT1
- OriGene qPCR primer pairs for HENMT1
- OriGene CRISPR knockouts for HENMT1
- OriGene ORF clones in human for HENMT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HENMT1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HENMT1
- GenScript Custom Assay Services for HENMT1
- GenScript Custom overexpressing Cell Line Services for HENMT1
- GenScript: Design CRISPR guide RNA sequences for HENMT1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HENMT1
- Novus Biologicals proteins and lysates for HENMT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HENMT1: See all 18
- Search antibodies-online for kits
- antibodies-online Proteins for HENMT1: See all 10
- Search antibodies-online for peptides
- GeneTex HENMT1 antibody for HENMT1
- Search GeneTex for Proteins for HENMT1
- ViGene Biosciences adenoviral particle packaged cDNA for HENMT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HENMT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HENMT1 gene
- Search ViGene Biosciences for HENMT1
- Horizon Cell Lines for HENMT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HENMT1
- VectorBuilder custom plasmid, inducible vectors for HENMT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HENMT1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HENMT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (147) VectorBuilder
- (148) SNPedia
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- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




