Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HENMT1 Gene

Aliases for HENMT1 Gene

  • HEN Methyltransferase 1 2 3
  • HEN1 Methyltransferase Homolog 1 2 3 4 5
  • C1orf59 3 4
  • HEN1 Methyltransferase Homolog 1 (Arabidopsis) 2
  • Hua Enhancer 1 Homolog 1 (Arabidopsis) 2
  • Chromosome 1 Open Reading Frame 59 2
  • Small RNA 2-O-Methyltransferase 3
  • Hua Enhancer 1 Homolog 1 3
  • EC 2.1.1.n8 4
  • HEN1 3

External Ids for HENMT1 Gene

Previous HGNC Symbols for HENMT1 Gene

  • C1orf59

Previous GeneCards Identifiers for HENMT1 Gene

  • GC01M109191

Summaries for HENMT1 Gene

GeneCards Summary for HENMT1 Gene

HENMT1 (HEN Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot for HENMT1 Gene

  • Methyltransferase that adds a 2-O-methyl group at the 3-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HENMT1 Gene

Genomics for HENMT1 Gene

Regulatory Elements for HENMT1 Gene

Enhancers for HENMT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G108696 2 dbSUPER 11.3 -37.7 -37666 4.6 HDGF PKNOX1 ARNT AGO1 ZNF133 ARID4B ZNF2 ZBTB7B GLIS2 FOS ENSG00000232971 HENMT1 GC01P108697 GC01M108671
GH01G108589 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +70.3 70277 3.4 ATF1 PKNOX1 CREB3L1 ARNT E2F7 FEZF1 TCF12 ZNF766 GATA2 ELK1 PRPF38B HENMT1 FAM102B TMEM167B STXBP3
GH01G108583 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +76.5 76491 3.8 ELF3 TBP FOXA2 PKNOX1 ATF1 BRCA1 RFX5 SMARCC2 RCOR1 FOS FAM102B PRPF38B HENMT1 STXBP3
GH01G108703 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -42.6 -42631 2.3 HDAC1 NFIB AGO1 SIN3A ZBTB40 RAD21 ZBTB7B FOS RELB RCOR1 ENSG00000232971 HENMT1 PRPF38B FAM102B TMEM167B GC01M108671 FNDC7
GH01G108643 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +15.1 15144 5.1 ATF1 PKNOX1 MLX ARID4B YY1 TCF12 ZNF121 ZNF766 KLF13 DEK PRPF38B STXBP3 HENMT1 TMEM167B FAM102B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HENMT1 on UCSC Golden Path with GeneCards custom track

Promoters for HENMT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010987 326 1201 SREBF2 SIN3A ZBTB40 ELK1 EGR1 POLR3A ZNF143 ZNF207 RCOR1 CREM

Genomic Location for HENMT1 Gene

Chromosome:
1
Start:
108,648,288 bp from pter
End:
108,661,526 bp from pter
Size:
13,239 bases
Orientation:
Minus strand

Genomic View for HENMT1 Gene

Genes around HENMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HENMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HENMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HENMT1 Gene

Proteins for HENMT1 Gene

  • Protein details for HENMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T8I9-HENMT_HUMAN
    Recommended name:
    Small RNA 2-O-methyltransferase
    Protein Accession:
    Q5T8I9
    Secondary Accessions:
    • A8MRR6
    • B1AM16
    • B1AM17
    • Q96EJ7
    • Q96NN0

    Protein attributes for HENMT1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44525 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12930.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HENMT1 Gene

neXtProt entry for HENMT1 Gene

Post-translational modifications for HENMT1 Gene

  • Ubiquitination at isoforms=100, isoforms=235, posLast=308308, posLast=325325, and isoforms=338
  • Modification sites at PhosphoSitePlus

Other Protein References for HENMT1 Gene

No data available for DME Specific Peptides for HENMT1 Gene

Domains & Families for HENMT1 Gene

Protein Domains for HENMT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HENMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T8I9

UniProtKB/Swiss-Prot:

HENMT_HUMAN :
  • Belongs to the methyltransferase superfamily. HEN1 family.
Family:
  • Belongs to the methyltransferase superfamily. HEN1 family.
genes like me logo Genes that share domains with HENMT1: view

Function for HENMT1 Gene

Molecular function for HENMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3-terminal 2-O-methylnucleotide.
UniProtKB/Swiss-Prot Function:
Methyltransferase that adds a 2-O-methyl group at the 3-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

Enzyme Numbers (IUBMB) for HENMT1 Gene

Gene Ontology (GO) - Molecular Function for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 22458338
GO:0008168 methyltransferase activity IEA --
GO:0008171 O-methyltransferase activity ISS --
GO:0008173 RNA methyltransferase activity ISS --
genes like me logo Genes that share ontologies with HENMT1: view
genes like me logo Genes that share phenotypes with HENMT1: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for HENMT1 Gene

Selected GeneGlobe predicted Target genes for HENMT1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for HENMT1 Gene

Localization for HENMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HENMT1 Gene

Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q568P9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HENMT1 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0043186 P granule ISS --
genes like me logo Genes that share ontologies with HENMT1: view

Pathways & Interactions for HENMT1 Gene

genes like me logo Genes that share pathways with HENMT1: view

Pathways by source for HENMT1 Gene

Interacting Proteins for HENMT1 Gene

Gene Ontology (GO) - Biological Process for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation ISS --
GO:0031047 gene silencing by RNA IEA --
GO:0032259 methylation IEA --
GO:0034587 piRNA metabolic process ISS --
genes like me logo Genes that share ontologies with HENMT1: view

No data available for SIGNOR curated interactions for HENMT1 Gene

Drugs & Compounds for HENMT1 Gene

(2) Drugs for HENMT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with HENMT1: view

Transcripts for HENMT1 Gene

Unigene Clusters for HENMT1 Gene

HEN1 methyltransferase homolog 1 (Arabidopsis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HENMT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for HENMT1 Gene

GeneLoc Exon Structure for
HENMT1
ECgene alternative splicing isoforms for
HENMT1

Expression for HENMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HENMT1 Gene

mRNA differential expression in normal tissues according to GTEx for HENMT1 Gene

This gene is overexpressed in Testis (x9.1).

Protein differential expression in normal tissues from HIPED for HENMT1 Gene

This gene is overexpressed in Testis (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HENMT1 Gene



Protein tissue co-expression partners for HENMT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HENMT1 Gene:

HENMT1

SOURCE GeneReport for Unigene cluster for HENMT1 Gene:

Hs.7962

Evidence on tissue expression from TISSUES for HENMT1 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with HENMT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HENMT1 Gene

Orthologs for HENMT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HENMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HENMT1 34 35
  • 99.83 (n)
rat
(Rattus norvegicus)
Mammalia Henmt1 34
  • 76.76 (n)
mouse
(Mus musculus)
Mammalia Henmt1 34 16 35
  • 76.13 (n)
cow
(Bos Taurus)
Mammalia HENMT1 34 35
  • 73.86 (n)
dog
(Canis familiaris)
Mammalia LOC479920 34
  • 70.05 (n)
HENMT1 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HENMT1 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves HENMT1 34 35
  • 57.14 (n)
lizard
(Anolis carolinensis)
Reptilia HENMT1 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia henmt1 34
  • 53.99 (n)
zebrafish
(Danio rerio)
Actinopterygii henmt1 34 35
  • 50.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hen1 34 35
  • 44.96 (n)
worm
(Caenorhabditis elegans)
Secernentea henn-1 35
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.976 35
  • 20 (a)
OneToOne
Species where no ortholog for HENMT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HENMT1 Gene

ENSEMBL:
Gene Tree for HENMT1 (if available)
TreeFam:
Gene Tree for HENMT1 (if available)

Paralogs for HENMT1 Gene

No data available for Paralogs for HENMT1 Gene

Variants for HENMT1 Gene

Sequence variations from dbSNP and Humsavar for HENMT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000149852 -- 108,662,199(+) GCTTC(C/G)GCCTG intron-variant, upstream-variant-2KB
rs1000233564 -- 108,657,756(+) TCATG(-/T)TAAGC intron-variant
rs1000237633 -- 108,656,864(+) CAAGA(G/T)CACAT intron-variant
rs1000663176 -- 108,661,670(+) TGGCC(C/T)AGTGA nc-transcript-variant, upstream-variant-2KB
rs1000820354 -- 108,661,883(+) AGGGG(G/T)GTGAG intron-variant, upstream-variant-2KB

Variation tolerance for HENMT1 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HENMT1 Gene

Human Gene Mutation Database (HGMD)
HENMT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HENMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HENMT1 Gene

Disorders for HENMT1 Gene

Relevant External Links for HENMT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HENMT1

No disorders were found for HENMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HENMT1 Gene

Publications for HENMT1 Gene

  1. HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. (PMID: 26496356) Lim S.L. … O'Bryan M.K. (PLoS Genet. 2015) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for HENMT1 Gene

Sources for HENMT1 Gene

Content
Loading form....