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Aliases for HENMT1 Gene

Aliases for HENMT1 Gene

  • HEN1 Methyltransferase Homolog 1 (Arabidopsis) 2 3
  • C1orf59 3 4 6
  • HEN1 3 6
  • HEN1 Methyltransferase Homolog (Arabidopsis) 2
  • Chromosome 1 Open Reading Frame 59 2
  • HEN1 Methyltransferase Homolog 1 4
  • Small RNA 2-O-Methyltransferase 3
  • EC 2.1.1.n8 4

External Ids for HENMT1 Gene

Previous HGNC Symbols for HENMT1 Gene

  • C1orf59

Previous GeneCards Identifiers for HENMT1 Gene

  • GC01M109191

Summaries for HENMT1 Gene

GeneCards Summary for HENMT1 Gene

HENMT1 (HEN1 Methyltransferase Homolog 1 (Arabidopsis)) is a Protein Coding gene. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot for HENMT1 Gene

  • Methyltransferase that adds a 2-O-methyl group at the 3-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HENMT1 Gene

Genomics for HENMT1 Gene

Genomic Location for HENMT1 Gene

Start:
108,648,288 bp from pter
End:
108,661,526 bp from pter
Size:
13,239 bases
Orientation:
Minus strand

Genomic View for HENMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HENMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HENMT1 Gene

No data available for Regulatory Elements for HENMT1 Gene

Proteins for HENMT1 Gene

  • Protein details for HENMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T8I9-HENMT_HUMAN
    Recommended name:
    Small RNA 2-O-methyltransferase
    Protein Accession:
    Q5T8I9
    Secondary Accessions:
    • A8MRR6
    • B1AM16
    • B1AM17
    • Q96EJ7
    • Q96NN0

    Protein attributes for HENMT1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44525 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12930.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HENMT1 Gene

neXtProt entry for HENMT1 Gene

Proteomics data for HENMT1 Gene at MOPED

Post-translational modifications for HENMT1 Gene

  • Ubiquitination at Lys100, Lys235, Lys308, Lys325, and Lys338
  • Modification sites at PhosphoSitePlus

Other Protein References for HENMT1 Gene

No data available for DME Specific Peptides for HENMT1 Gene

Domains for HENMT1 Gene

Protein Domains for HENMT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HENMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T8I9

UniProtKB/Swiss-Prot:

HENMT_HUMAN :
  • Q5T8I9
Family:
  • Belongs to the methyltransferase superfamily. HEN1 family.
genes like me logo Genes that share domains with HENMT1: view

No data available for Gene Families for HENMT1 Gene

Function for HENMT1 Gene

Molecular function for HENMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3-terminal 2-O-methylnucleotide
UniProtKB/Swiss-Prot Function: Methyltransferase that adds a 2-O-methyl group at the 3-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity).

Enzyme Numbers (IUBMB) for HENMT1 Gene

Gene Ontology (GO) - Molecular Function for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 22458338
GO:0008171 O-methyltransferase activity ISS --
GO:0008173 RNA methyltransferase activity ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HENMT1: view

Transcription Factor Targeting for HENMT1 Gene

Selected GeneGlobe predicted Target genes for HENMT1

No data available for Phenotypes , Animal Models , miRNA and HOMER Transcription for HENMT1 Gene

Localization for HENMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HENMT1 Gene

Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043186 P granule ISS --
genes like me logo Genes that share ontologies with HENMT1: view

No data available for Subcellular locations from COMPARTMENTS for HENMT1 Gene

Pathways for HENMT1 Gene

SuperPathways for HENMT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HENMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation ISS --
GO:0010467 gene expression TAS --
GO:0031047 gene silencing by RNA IEA --
GO:0034587 piRNA metabolic process TAS --
genes like me logo Genes that share ontologies with HENMT1: view

No data available for Pathways by source for HENMT1 Gene

Transcripts for HENMT1 Gene

Unigene Clusters for HENMT1 Gene

HEN1 methyltransferase homolog 1 (Arabidopsis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HENMT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for HENMT1 Gene

GeneLoc Exon Structure for
HENMT1
ECgene alternative splicing isoforms for
HENMT1

Expression for HENMT1 Gene

mRNA expression in normal human tissues for HENMT1 Gene

mRNA differential expression in normal tissues according to GTEx for HENMT1 Gene

This gene is overexpressed in Testis (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HENMT1 Gene

SOURCE GeneReport for Unigene cluster for HENMT1 Gene Hs.7962

genes like me logo Genes that share expressions with HENMT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HENMT1 Gene

Orthologs for HENMT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HENMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HENMT1 35
  • 99.83 (n)
  • 100 (a)
HENMT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HENMT1 35
  • 73.86 (n)
  • 61.32 (a)
HENMT1 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HENMT1 36
  • 56 (a)
OneToOne
LOC479920 35
  • 70.05 (n)
  • 59.89 (a)
mouse
(Mus musculus)
Mammalia Henmt1 35
  • 76.13 (n)
  • 69.79 (a)
Henmt1 16
Henmt1 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HENMT1 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Henmt1 35
  • 76.76 (n)
  • 72.06 (a)
chicken
(Gallus gallus)
Aves HENMT1 35
  • 57.14 (n)
  • 46.63 (a)
HENMT1 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HENMT1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia henmt1 35
  • 53.99 (n)
  • 45.07 (a)
zebrafish
(Danio rerio)
Actinopterygii henmt1 35
  • 50.87 (n)
  • 43.35 (a)
henmt1 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hen1 35
  • 44.96 (n)
  • 35.63 (a)
Hen1 36
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea henn-1 36
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.976 36
  • 20 (a)
OneToOne
Species with no ortholog for HENMT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HENMT1 Gene

ENSEMBL:
Gene Tree for HENMT1 (if available)
TreeFam:
Gene Tree for HENMT1 (if available)

Paralogs for HENMT1 Gene

No data available for Paralogs for HENMT1 Gene

Variants for HENMT1 Gene

Sequence variations from dbSNP and Humsavar for HENMT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14504 -- 108,648,343(+) AAAAA(G/T)TCCAA utr-variant-3-prime
rs768521 -- 108,649,920(-) tccta(G/T)catgt intron-variant
rs957170 -- 108,649,967(-) TCTTA(A/G)AATAC intron-variant
rs2270714 -- 108,660,174(-) aactt(A/C/T)ggtgt intron-variant
rs2270715 -- 108,660,044(-) GAAAG(A/C)GGCTT intron-variant

Relevant External Links for HENMT1 Gene

HapMap Linkage Disequilibrium report
HENMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HENMT1 Gene

Disorders for HENMT1 Gene

No disorders were found for HENMT1 Gene.

No data available for UniProtKB/Swiss-Prot for HENMT1 Gene

Publications for HENMT1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PMID: 19850743) Vanderwerf S.M. … Bagby G.C. (Blood 2009) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for HENMT1 Gene

  • antibodies-online proteins for HENMT1
  • antibodies-online antibodies for HENMT1
  • antibodies-online kits for HENMT1

Sources for HENMT1 Gene

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