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HEMGN Gene(Protein Coding)

Hemogen

GCID:
GC09M097927
GIFtS:
50
Genes Participants
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Aliases for HEMGN Gene

Aliases for HEMGN Gene

  • Hemogen 2 3 3 5
  • Erythroid Differentiation-Associated Gene Protein 3 4
  • Negative Differentiation Regulator Protein 3 4
  • Hemopoietic Gene Protein 3 4
  • EDAG-1 3 4
  • EDAG 3 4
  • NDR 3 4
  • CT155 3

External Ids for HEMGN Gene

Previous GeneCards Identifiers for HEMGN Gene

  • GC09M091514
  • GC09M092432
  • GC09M094146
  • GC09M096068
  • GC09M097768
  • GC09M099729
  • GC09M100689
  • GC09M070290

Summaries for HEMGN Gene

GeneCards Summary for HEMGN Gene

HEMGN (Hemogen) is a Protein Coding gene. Diseases associated with HEMGN include Isolated Cleft Lip.

UniProtKB/Swiss-Prot for HEMGN Gene

  • Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

Gene Wiki entry for HEMGN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEMGN Gene

Genomics for HEMGN Gene

Products:

  1. Regulatory Element

Regulatory Elements for HEMGN Gene

Enhancers for HEMGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G097918 1.8 FANTOM5 ENCODE dbSUPER 12.6 +23.7 23678 5.9 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC NCBP1 TRMO ZNF322P1 ANP32B ENSG00000236896 HEMGN MFSD14C RNU6-918P XPA ZNF782
GH09G098070 1.4 Ensembl ENCODE dbSUPER 10.6 -128.8 -128821 5.7 HDGF PKNOX1 FOXA2 YBX1 ZNF121 ZNF143 ZNF207 FOS REST ZNF579 TRIM14 TBC1D2 RNU6-918P CORO2A HEMGN NANS GC09M098216 GC09M098221 PIR35853
GH09G097501 1.6 FANTOM5 ENCODE dbSUPER 6.5 +441.4 441431 4.7 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 YY1 ZNF766 KLF13 JUNB HEMGN VN1R51P TMOD1 ANP32B LOC105376168
GH09G098009 0.9 ENCODE dbSUPER 11 -65.4 -65406 1.9 MAX MNT NR2F2 POLR2A NBN ZNF143 FOS MYC SUPT5H ENSG00000236896 ANP32B HEMGN TBC1D2 TRIM14 GC09P098033
GH09G098078 0.9 FANTOM5 dbSUPER 10.5 -134.1 -134110 0.4 ZNF316 MAFG EMSY MAFK TBC1D2 TRIM14 RNU6-918P CORO2A HEMGN TRMO GC09M098221 PIR35853 GC09M098216 NANS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HEMGN on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HEMGN gene promoter:

Genomic Location for HEMGN Gene

Chromosome:
9
Start:
97,926,791 bp from pter
End:
97,944,915 bp from pter
Size:
18,125 bases
Orientation:
Minus strand

Genomic View for HEMGN Gene

Genes around HEMGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEMGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEMGN Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HEMGN Gene

Proteins for HEMGN Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HEMGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXL5-HEMGN_HUMAN
    Recommended name:
    Hemogen
    Protein Accession:
    Q9BXL5
    Secondary Accessions:
    • Q6XAR3
    • Q86XY5
    • Q9NPC0

    Protein attributes for HEMGN Gene

    Size:
    484 amino acids
    Molecular mass:
    55341 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF67133.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF71041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35488.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for HEMGN Gene

Protein Expression for HEMGN Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HEMGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEMGN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEMGN Gene

Domains & Families for HEMGN Gene

Protein Domains for HEMGN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HEMGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HEMGN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HEMGN Gene

Function for HEMGN Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HEMGN Gene

UniProtKB/Swiss-Prot Function:
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
UniProtKB/Swiss-Prot Induction:
Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens.

Gene Ontology (GO) - Molecular Function for HEMGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with HEMGN: view
genes like me logo Genes that share phenotypes with HEMGN: view

Animal Models for HEMGN Gene

MGI Knock Outs for HEMGN:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HEMGN Gene

Localization for HEMGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEMGN Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HEMGN gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HEMGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA --
genes like me logo Genes that share ontologies with HEMGN: view

Pathways & Interactions for HEMGN Gene

SuperPathways for HEMGN Gene

PathCards logo More details on SuperPathways for HEMGN
No Data Available

Gene Ontology (GO) - Biological Process for HEMGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0045667 regulation of osteoblast differentiation IBA --
genes like me logo Genes that share ontologies with HEMGN: view

No data available for Pathways by source and SIGNOR curated interactions for HEMGN Gene

Drugs & Compounds for HEMGN Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HEMGN Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HEMGN Gene

(5) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HEMGN Gene

Hemogen:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEMGN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b
SP1: - - - - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: - - - - - -

Relevant External Links for HEMGN Gene

GeneLoc Exon Structure for
HEMGN
ECgene alternative splicing isoforms for
HEMGN

Expression for HEMGN Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HEMGN Gene

mRNA expression in normal human tissues for HEMGN Gene
mRNA expression by BioGPS for HEMGN GenemRNA expression by GTEx for HEMGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEMGN Gene

This gene is overexpressed in Testis (x32.3) and Whole Blood (x14.4).

Protein differential expression in normal tissues from HIPED for HEMGN Gene

This gene is overexpressed in Fetal Liver (46.7) and Stomach (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HEMGN Gene



NURSA nuclear receptor signaling pathways regulating expression of HEMGN Gene:

HEMGN

SOURCE GeneReport for Unigene cluster for HEMGN Gene:

Hs.176626

mRNA Expression by UniProt/SwissProt for HEMGN Gene:

Q9BXL5-HEMGN_HUMAN
Tissue specificity: Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.

Evidence on tissue expression from TISSUES for HEMGN Gene

  • Bone marrow(4.5)
  • Nervous system(4.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with HEMGN: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEMGN Gene

Orthologs for HEMGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEMGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HEMGN 34 35
  • 99.31 (n)
dog
(Canis familiaris)
 Mammalia HEMGN 34 35
  • 81.81 (n)
cow
(Bos Taurus)
 Mammalia HEMGN 34 35
  • 80.5 (n)
mouse
(Mus musculus)
 Mammalia Hemgn 34 16 35
  • 69.9 (n)
rat
(Rattus norvegicus)
 Mammalia Hemgn 34
  • 65.25 (n)
oppossum
(Monodelphis domestica)
 Mammalia HEMGN 35
  • 30 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HEMGN 35
  • 31 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia HEMGN 35
  • 39 (a)
 OneToOne
Species where no ortholog for HEMGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HEMGN Gene

ENSEMBL:
Gene Tree for HEMGN (if available)
TreeFam:
Gene Tree for HEMGN (if available)

Paralogs for HEMGN Gene

No data available for Paralogs for HEMGN Gene

Variants for HEMGN Gene

Sequence variations from dbSNP and Humsavar for HEMGN Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000092327 -- 97,944,167(+) ATATG(A/T)CTGAG intron-variant
rs1000272795 -- 97,941,226(+) AACTG(A/T)TGGAG intron-variant, upstream-variant-2KB
rs1000736294 -- 97,936,001(+) AGGTG(A/T)AACTC intron-variant
rs1000803091 -- 97,928,045(+) TTTTT(C/G)AGCCG intron-variant
rs1000877576 -- 97,944,528(+) AAGTG(G/T)CTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEMGN Gene

Variant ID Type Subtype PubMed ID
nsv1048135 CNV loss 25217958
nsv472589 CNV novel sequence insertion 20440878

Variation tolerance for HEMGN Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HEMGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HEMGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEMGN Gene

Disorders for HEMGN Gene

MalaCards: The human disease database

(1) MalaCards diseases for HEMGN Gene - From: GeneCards

Disorder Aliases PubMed IDs
isolated cleft lip
- elite association - COSMIC cancer census association via MalaCards
Search HEMGN in MalaCards View complete list of genes associated with diseases

Relevant External Links for HEMGN

Genetic Association Database (GAD)
HEMGN
Human Genome Epidemiology (HuGE) Navigator
HEMGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEMGN
genes like me logo Genes that share disorders with HEMGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HEMGN Gene

Publications for HEMGN Gene

  1. Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis. (PMID: 14648837) Yang L.V. … Li L. (Dev. Dyn. 2003) 3 4 22 64
  2. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 46 64
  3. FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. (PMID: 19779022) Moreno L.M. … Lidral A.C. (Hum. Mol. Genet. 2009) 3 46 64
  4. High expression of EDAG and its significance in AML. (PMID: 15920494) An L.-L. … Song Y.-H. (Leukemia 2005) 3 4 64
  5. Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells. (PMID: 14730214) Liu C.-C. … Ch'ang L.-Y. (J. Biomed. Sci. 2004) 3 4 64

Products for HEMGN Gene

Sources for HEMGN Gene

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