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HEMGN Gene

protein-coding GIFtS: 48
GCID: GC09M100689

Hemogen

See HEMGN-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
hemogen¹ ²		Negative Differentiation Regulator Protein² ³
EDAG² ³ ⁵		EDAG-1² ³
Erythroid Differentiation-Associated Gene Protein² ³		NDR² ³
Hemopoietic Gene Protein² ³		CT155²

External Ids:	HGNC: 17509¹	Entrez Gene: 55363²	Ensembl: ENSG00000136929⁷	OMIM: 610715⁵	UniProtKB: Q9BXL5³

Export aliases for HEMGN gene to outside databases

Previous GC identifers: GC09M091514 GC09M092432 GC09M094146 GC09M096068 GC09M097768 GC09M099729 GC09M070290

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HEMGN Gene:

HEMGN (hemogen) is a protein-coding gene. Diseases associated with HEMGN include non-hodgkin lymphoma.

UniProtKB/Swiss-Prot: HEMGN_HUMAN, Q9BXL5

Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the

TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the

activation of the nuclear factor-kappa B (NF-kB)

Gene Wiki entry for HEMGN Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000009.11 NT_008470.20 NC_018920.2

Regulatory elements:

Regulatory transcription factor binding sites in the HEMGN gene promoter:
AREB6 AML1a FOXJ2 (long isoform) IRF-7A FOXJ2 Pax-4a NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HEMGN promoter sequence

Search Chromatin IP Primers for HEMGN

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HEMGN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.33

HEMGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEMGN gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M100689: view genomic region (about GC identifiers)

Start:	100,689,073 bp from pter	End:	100,707,138 bp from pter
Size:	18,066 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HEMGN_HUMAN, Q9BXL5 (See protein sequence)

Recommended Name: Hemogen

Size: 484 amino acids; 55341 Da

Developmental stage: Expressed in fetal liver, kidney and brain

Sequence caution: Sequence=AAF67133.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAF71041.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAG35488.1;

Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q6XAR3 Q86XY5 Q9NPC0

Explore the universe of human proteins at neXtProt for HEMGN: NX_Q9BXL5

Explore proteomics data for HEMGN at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See HEMGN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_060907.2 NP_932095.1

ENSEMBL proteins:

ENSP00000259456

HEMGN Human Recombinant Protein Products:

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	antibodies-online antibodies for HEMGN (26 products)

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9BXL5

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: HEMGN_HUMAN, Q9BXL5

Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the

TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the

activation of the nuclear factor-kappa B (NF-kB)

Induction: Down-regulated during megakaryocytic differentiation of K562 cells by

12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

Find genes that share ontologies with HEMGN About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for HEMGN:

Increased gamma-H2AX phosphory

1 MGI phenotypic allele

for Hemgn (no phenotypes)

Find genes that share phenotypes with HEMGN About GenesLikeMe

Animal Models:
MGI mouse knock-out Hemgn^{tm1(KOMP)Vlcg} for HEMGN

genOway: Develop your customized and physiologically relevant rodent model for HEMGN

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

HEMGN_HUMAN, Q9BXL5: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	3
plasma membrane	3

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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	IEA	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for HEMGN
Interactions:

Search GeneGlobe Interaction Network for HEMGN

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

Selected Interacting proteins for HEMGN (Q9BXL5^{1, 2} ENSP00000259456⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NPM1	P06748¹^,²	EBI-3916399,EBI-78579 MINT-8373211 MINT-8373408 MINT-8373290 MINT-8373312 MINT-8373326 MINT-8373269 MINT-8373241
CBX5	P45973², ENSP00000209875⁴	MINT-7220149 STRING: ENSP00000209875
CTBP1	Q13363¹, ENSP00000290921⁴	EBI-3916399,EBI-908846 STRING: ENSP00000290921
ACTB	P60709²	MINT-7220149
CHAF1A	Q13111²	MINT-7220149

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0045667	regulation of osteoblast differentiation	IEA	--

Find genes that share ontologies with HEMGN About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for HEMGN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HEMGN gene (2 alternative transcripts):

NM_018437.4 NM_197978.2

Unigene Cluster for HEMGN:

Hemogen

Hs.176626 [show with all ESTs]

Unigene Representative Sequence: AY244805

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000259456

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Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA1-10051) for HEMGN

Additional mRNA sequence:

AF116617.1 AF228713.2 AF306681.1 AF306682.1 AF306683.1 AF322875.1 AK292441.1 AL833094.1

AY244805.1 AY255672.1 BC048324.1

6 DOTS entries:

DT.420059 DT.100654530 DT.95272874 DT.121168421 DT.70103439 DT.40277937

Selected AceView cDNA sequences (see all 73):

AF322875 AA676259 AI114455 AA496130 AF306682 BX099803 NM_018437 AY255672

BP369905 NM_197978 AF130060 AL597698 AF306683 BX426753 AL833094 BG941050

BI825348 AY244805 BI827170 AI248618 BX445350 AF116617 BX506409 AA435626

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for HEMGN (see all 6) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b
SP1:					-		-		-		-		-
SP2:											-		-
SP3:													-
SP4:													-
SP5:

ECgene alternative splicing isoforms for HEMGN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HEMGN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

HEMGN expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 10) fully expand


Liver (Hepatobiliary System) fully expand to see all 3 entries
Hematopoietic Stem Cells Liver Bud
Liver Lobule

Blood (Cardiovascular System) fully expand to see all 2 entries
Hematopoietic Stem Cells Liver Bud

Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Muscle Progenitor Cells Mandibular Arch Muscles

Bone (Muscoskeletal System)
Bone Marrow

Kidney (Urinary System)
Metanephric Mesenchyme Cells Metanephric Mesenchyme

HEMGN Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

HEMGN Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.176626

UniProtKB/Swiss-Prot: HEMGN_HUMAN, Q9BXL5

Tissue specificity: Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level).

Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in

thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells

(PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HEMGN gene from Selected species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hemgn^{1 , 5}	hemogen^{1, 5}	69.9(n)¹ 51.54(a)¹		4 (24.73 cM)⁵ 93966¹ NM_053149.2¹ NP_444379.1¹ 46393989⁵
chicken (Gallus gallus)	Aves	HEMGN⁶	hemogen	31(a)	1 ↔ 1	Z(70487737-70492461)
lizard (Anolis carolinensis)	Reptilia	HEMGN⁶	hemogen	39(a)	1 ↔ 1	GL343544.1(215994-220919)

ENSEMBL Gene Tree for HEMGN (if available)
TreeFam Gene Tree for HEMGN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7030907^1,2	C,F,A,H	--	100688577(+)	`ATTTAC/TCATAT`	2	--	int¹		9		NS EA CSA WA NA	780
rs189912006^1,2		--	100688694(+)	`CTAGTA/TATATG`	2	--	int¹		0	--	--	--	--
rs181223097^1,2	C	--	100689026(+)	`TTAGAC/TAGGTC`	2	--	int¹		0	--	--	--	--
rs185822762^1,2		--	100689043(+)	`CCTCCA/GCAATT`	2	--	int¹		0	--	--	--	--
rs77357203^1,2	C	--	100689107(+)	`TTGTGA/CACAAA`	2	--	ut3¹		0	--	--	--	--
rs192066044^1,2		--	100689370(+)	`TAGGGA/GGGAAA`	2	--	ut3¹		0	--	--	--	--
rs77253143^1,2	C,F	--	100689375(+)	`GGGAAA/TACCAA`	2	--	ut3¹		1		WA	118
rs34825770^1,2	C	--	100689451(+)	`TACAT-/ACACACA`	2	--	ut3¹		0	--	--	--	--
rs72109422^1,2	C	--	100689451(+)	`TACAT-/ACA CACACACACA`	2	--	ut3¹		0	--	--	--	--
rs59177658^1,2	C	--	100689452(+)	`ACACA-/CACACAC`	2	--	ut3¹		2		NA CSA	4

HapMap Linkage Disequilibrium report for HEMGN (100689073 - 100707138 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for HEMGN: About this table

Variant ID	Type	Subtype	PubMed ID
nsv893611	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HEMGN

DNA2.0 Custom Variant and Variant Library Synthesis for HEMGN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610715 OMIM disorders: --

1 disease for HEMGN:
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non-hodgkin lymphoma

Find genes that share disorders with HEMGN About GenesLikeMe

Genetic Association Database (GAD): HEMGN
Human Genome Epidemiology (HuGE) Navigator: HEMGN (2 documents)

Export disorders for HEMGN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HEMGN gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with HEMGN)

Utopia: connect your pdf to the dynamic
world of online information

Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis. (PubMed id 14648837)^{1, 2, 9} Yang L.V.... Li L. (Dev. Dyn. 2003)
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)^{1, 4} Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. (PubMed id 19779022)^{1, 4} Moreno L.M....Lidral A.C. (Hum. Mol. Genet. 2009)
High expression of EDAG and its significance in AML. (PubMed id 15920494)^{1, 2} An L.-L....Song Y.-H. (Leukemia 2005)
EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B. (PubMed id 15332117)^{1, 2} Li C.Y.... Yang X.M. (Cell Death Differ. 2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (Nature 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells. (PubMed id 14730214)^{1, 2} Liu C.-C.... Ch'ang L.-Y. (J. Biomed. Sci. 2004)
Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. (PubMed id 11404085)^{1, 2} Yang L.V.... Li L. (Mech. Dev. 2001)
Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PubMed id 23436708)² Liu M....Sha J. (Proteomics 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55363	HGNC: 17509	AceView: HEMGN	Ensembl:ENSG00000136929	euGenes: HUgn55363
ECgene: HEMGN	H-InvDB: HEMGN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HEMGN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HEMGN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HEMGN gene:
Search GeneIP for patents involving HEMGN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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