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Aliases for HEMGN Gene

Aliases for HEMGN Gene

  • Hemogen 2 3
  • EDAG 3 4 6
  • Erythroid Differentiation-Associated Gene Protein 3 4
  • Negative Differentiation Regulator Protein 3 4
  • Hemopoietic Gene Protein 3 4
  • EDAG-1 3 4
  • NDR 3 4
  • CT155 3

External Ids for HEMGN Gene

Previous GeneCards Identifiers for HEMGN Gene

  • GC09M091514
  • GC09M092432
  • GC09M094146
  • GC09M096068
  • GC09M097768
  • GC09M099729
  • GC09M100689
  • GC09M070290

Summaries for HEMGN Gene

GeneCards Summary for HEMGN Gene

HEMGN (Hemogen) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HEMGN Gene

  • Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

Gene Wiki entry for HEMGN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEMGN Gene

Genomics for HEMGN Gene

Regulatory Elements for HEMGN Gene

Genomic Location for HEMGN Gene

Start:
97,926,791 bp from pter
End:
97,944,915 bp from pter
Size:
18,125 bases
Orientation:
Minus strand

Genomic View for HEMGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEMGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEMGN Gene

Proteins for HEMGN Gene

  • Protein details for HEMGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXL5-HEMGN_HUMAN
    Recommended name:
    Hemogen
    Protein Accession:
    Q9BXL5
    Secondary Accessions:
    • Q6XAR3
    • Q86XY5
    • Q9NPC0

    Protein attributes for HEMGN Gene

    Size:
    484 amino acids
    Molecular mass:
    55341 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF67133.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF71041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35488.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for HEMGN Gene

Proteomics data for HEMGN Gene at MOPED

Post-translational modifications for HEMGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEMGN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HEMGN Gene

Domains for HEMGN Gene

Protein Domains for HEMGN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HEMGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HEMGN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HEMGN Gene

Function for HEMGN Gene

Molecular function for HEMGN Gene

UniProtKB/Swiss-Prot Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
UniProtKB/Swiss-Prot Induction: Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens.

Gene Ontology (GO) - Molecular Function for HEMGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with HEMGN: view

Phenotypes for HEMGN Gene

GenomeRNAi human phenotypes for HEMGN:
genes like me logo Genes that share phenotypes with HEMGN: view

Animal Model Products

CRISPR Products

miRNA for HEMGN Gene

miRTarBase miRNAs that target HEMGN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HEMGN Gene

Localization for HEMGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEMGN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEMGN Gene COMPARTMENTS Subcellular localization image for HEMGN gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for HEMGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IBA --
genes like me logo Genes that share ontologies with HEMGN: view

Pathways for HEMGN Gene

SuperPathways for HEMGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for HEMGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation IEA --
GO:0045667 regulation of osteoblast differentiation IBA --
genes like me logo Genes that share ontologies with HEMGN: view

No data available for Pathways by source for HEMGN Gene

Transcripts for HEMGN Gene

Unigene Clusters for HEMGN Gene

Hemogen:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEMGN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEMGN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b
SP1: - - - - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: - - - - - -

Relevant External Links for HEMGN Gene

GeneLoc Exon Structure for
HEMGN
ECgene alternative splicing isoforms for
HEMGN

Expression for HEMGN Gene

mRNA expression in normal human tissues for HEMGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEMGN Gene

This gene is overexpressed in Testis (32.3) and Whole Blood (14.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEMGN Gene

SOURCE GeneReport for Unigene cluster for HEMGN Gene Hs.176626

mRNA Expression by UniProt/SwissProt for HEMGN Gene

Q9BXL5-HEMGN_HUMAN
Tissue specificity: Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.
genes like me logo Genes that share expressions with HEMGN: view

In Situ Assay Products

Orthologs for HEMGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEMGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEMGN 35
  • 99.31 (n)
  • 98.55 (a)
HEMGN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HEMGN 35
  • 80.5 (n)
  • 65.76 (a)
HEMGN 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEMGN 35
  • 81.81 (n)
  • 67.59 (a)
HEMGN 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hemgn 35
  • 69.9 (n)
  • 51.54 (a)
Hemgn 16
Hemgn 36
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HEMGN 36
  • 30 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hemgn 35
  • 65.25 (n)
  • 46.19 (a)
chicken
(Gallus gallus)
Aves HEMGN 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEMGN 36
  • 39 (a)
OneToOne
Species with no ortholog for HEMGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HEMGN Gene

ENSEMBL:
Gene Tree for HEMGN (if available)
TreeFam:
Gene Tree for HEMGN (if available)

Paralogs for HEMGN Gene

No data available for Paralogs for HEMGN Gene

Variants for HEMGN Gene

Sequence variations from dbSNP and Humsavar for HEMGN Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2435 -- 97,930,112(+) TTTCT(C/T)GGTGT reference, missense
rs2436 -- 97,930,148(+) CATCC(G/T)TATTT reference, missense
rs755109 -- 97,933,921(+) AAACC(C/T)GATTC intron-variant
rs1059003 -- 97,927,411(-) GAAAA(C/T)GATGT synonymous-codon, reference
rs1348387 -- 97,931,435(+) ACTTC(C/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEMGN Gene

Variant ID Type Subtype PubMed ID
nsv893611 CNV Gain 21882294

Relevant External Links for HEMGN Gene

HapMap Linkage Disequilibrium report
HEMGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEMGN Gene

Disorders for HEMGN Gene

Relevant External Links for HEMGN

Genetic Association Database (GAD)
HEMGN
Human Genome Epidemiology (HuGE) Navigator
HEMGN
genes like me logo Genes that share disorders with HEMGN: view

No data available for UniProtKB/Swiss-Prot for HEMGN Gene

Publications for HEMGN Gene

  1. Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis. (PMID: 14648837) Yang L.V. … Li L. (Dev. Dyn. 2003) 3 4 23
  2. Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. (PMID: 11404085) Yang L.V. … Li L. (Mech. Dev. 2001) 3 4
  3. Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells. (PMID: 14730214) Liu C.-C. … Ch'ang L.-Y. (J. Biomed. Sci. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B. (PMID: 15332117) Li C.Y. … Yang X.M. (Cell Death Differ. 2004) 3 4

Products for HEMGN Gene

Sources for HEMGN Gene

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