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HEMGN Gene(Protein Coding)

Hemogen

GCID:
GC09M097927
GIFtS:
50
Genes Participants
UDN Logo

Aliases for HEMGN Gene

Aliases for HEMGN Gene

  • Hemogen 2 3 5
  • Erythroid Differentiation-Associated Gene Protein 3 4
  • Negative Differentiation Regulator Protein 3 4
  • Hemopoietic Gene Protein 3 4
  • EDAG-1 3 4
  • EDAG 3 4
  • NDR 3 4
  • CT155 3

External Ids for HEMGN Gene

Previous GeneCards Identifiers for HEMGN Gene

  • GC09M091514
  • GC09M092432
  • GC09M094146
  • GC09M096068
  • GC09M097768
  • GC09M099729
  • GC09M100689
  • GC09M070290

Summaries for HEMGN Gene

GeneCards Summary for HEMGN Gene

HEMGN (Hemogen) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HEMGN Gene

  • Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

Gene Wiki entry for HEMGN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEMGN Gene

Genomics for HEMGN Gene

Products:

  1. Regulatory Element

Regulatory Elements for HEMGN Gene

Enhancers for HEMGN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HEMGN on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HEMGN gene promoter:

Genomic Location for HEMGN Gene

Chromosome:
9
Start:
97,926,791 bp from pter
End:
97,944,915 bp from pter
Size:
18,125 bases
Orientation:
Minus strand

Genomic View for HEMGN Gene

Genes around HEMGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEMGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEMGN Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HEMGN Gene

Proteins for HEMGN Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HEMGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXL5-HEMGN_HUMAN
    Recommended name:
    Hemogen
    Protein Accession:
    Q9BXL5
    Secondary Accessions:
    • Q6XAR3
    • Q86XY5
    • Q9NPC0

    Protein attributes for HEMGN Gene

    Size:
    484 amino acids
    Molecular mass:
    55341 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF67133.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF71041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35488.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for HEMGN Gene

Proteomics data for HEMGN Gene at MOPED

Protein Expression for HEMGN Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HEMGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEMGN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEMGN Gene

Domains & Families for HEMGN Gene

Protein Domains for HEMGN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HEMGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HEMGN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HEMGN Gene

Function for HEMGN Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HEMGN Gene

UniProtKB/Swiss-Prot Function:
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
UniProtKB/Swiss-Prot Induction:
Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens.

Phenotypes for HEMGN Gene

GenomeRNAi human phenotypes for HEMGN:
genes like me logo Genes that share phenotypes with HEMGN: view

Animal Model Products

miRNA for HEMGN Gene

miRTarBase miRNAs that target HEMGN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HEMGN Gene

Localization for HEMGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEMGN Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEMGN Gene COMPARTMENTS Subcellular localization image for HEMGN gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for HEMGN Gene

Pathways & Interactions for HEMGN Gene

SuperPathways for HEMGN Gene

PathCards logoMore details on SuperPathways for HEMGN
No Data Available

Gene Ontology (GO) - Biological Process for HEMGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045667 regulation of osteoblast differentiation IEA,IBA --
genes like me logo Genes that share ontologies with HEMGN: view

No data available for Pathways by source and SIGNOR curated interactions for HEMGN Gene

Drugs & Compounds for HEMGN Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HEMGN Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HEMGN Gene

(5) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HEMGN Gene

Hemogen:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEMGN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b
SP1: - - - - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: - - - - - -

Relevant External Links for HEMGN Gene

GeneLoc Exon Structure for
HEMGN
ECgene alternative splicing isoforms for
HEMGN

Expression for HEMGN Gene

Products:

  1. Primer

mRNA expression in normal human tissues for HEMGN Gene

mRNA expression in normal human tissues for HEMGN Gene
mRNA expression by BioGPS for HEMGN GenemRNA expression by GTEx for HEMGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEMGN Gene

This gene is overexpressed in Testis (x32.3) and Whole Blood (x14.4).

Protein differential expression in normal tissues from HIPED for HEMGN Gene

This gene is overexpressed in Fetal Liver (46.7) and Stomach (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEMGN Gene



SOURCE GeneReport for Unigene cluster for HEMGN Gene Hs.176626

mRNA Expression by UniProt/SwissProt for HEMGN Gene

Q9BXL5-HEMGN_HUMAN
Tissue specificity: Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.
genes like me logo Genes that share expression patterns with HEMGN: view

Primer Products

No data available for Protein tissue co-expression partners for HEMGN Gene

Orthologs for HEMGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEMGN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia HEMGN 35
  • 80.5 (n)
  • 65.76 (a)
HEMGN 36
  • 62 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia HEMGN 35
  • 81.81 (n)
  • 67.59 (a)
HEMGN 36
  • 62 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Hemgn 35
  • 69.9 (n)
  • 51.54 (a)
Hemgn 16
Hemgn 36
  • 44 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia HEMGN 35
  • 99.31 (n)
  • 98.55 (a)
HEMGN 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Hemgn 35
  • 65.25 (n)
  • 46.19 (a)
oppossum
(Monodelphis domestica)
 Mammalia HEMGN 36
  • 30 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HEMGN 36
  • 31 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia HEMGN 36
  • 39 (a)
 OneToOne
Species with no ortholog for HEMGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HEMGN Gene

ENSEMBL:
Gene Tree for HEMGN (if available)
TreeFam:
Gene Tree for HEMGN (if available)

Paralogs for HEMGN Gene

No data available for Paralogs for HEMGN Gene

Variants for HEMGN Gene

Sequence variations from dbSNP and Humsavar for HEMGN Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs755109 -- 97,933,921(+) AAACC(C/T)GATTC intron-variant
rs1059003 -- 97,927,411(-) GAAAA(C/T)GATGT reference, synonymous-codon
rs1348387 -- 97,931,435(+) ACTTC(A/C/G)TGGCA intron-variant
rs1443437 -- 97,938,185(+) GCAGC(C/T)TAGAT utr-variant-5-prime
rs1475695 -- 97,928,886(+) TACAG(A/G)ATAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEMGN Gene

Variant ID Type Subtype PubMed ID
nsv893611 CNV Gain 21882294

Variation tolerance for HEMGN Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HEMGN Gene

Disorders for HEMGN Gene

Relevant External Links for HEMGN

Genetic Association Database (GAD)
HEMGN
Human Genome Epidemiology (HuGE) Navigator
HEMGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEMGN

No disorders were found for HEMGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEMGN Gene

Publications for HEMGN Gene

  1. Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis. (PMID: 14648837) Yang L.V. … Li L. (Dev. Dyn. 2003) 3 4 23 67
  2. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. (PMID: 24740910) Zheng W.W. … Yang X.M. (Stem Cells 2014) 3
  3. Erythroid differentiation-associated gene interacts with NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis. (PMID: 22712502) Zhang M.J. … Yang X.M. (FEBS J. 2012) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. (PMID: 20350937) Takahashi M. … Yamashita S. (Hum. Mol. Genet. 2010) 3

Products for HEMGN Gene

Sources for HEMGN Gene

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