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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HEMGN Gene

protein-coding GIFtS: 47
GCID: GC09M100689

Hemogen

7 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
hemogen¹ ²		Negative Differentiation Regulator Protein² ³
EDAG² ³ ⁵		EDAG-1² ³
Erythroid Differentiation-Associated Gene Protein² ³		NDR³
Hemopoietic Gene Protein² ³

External Ids:	HGNC: 17509¹	Entrez Gene: 55363²	Ensembl: ENSG00000136929⁷	OMIM: 610715⁵	UniProtKB: Q9BXL5³

Export aliases for HEMGN gene to outside databases

Previous GC identifers: GC09M091514 GC09M092432 GC09M094146 GC09M096068 GC09M097768 GC09M099729 GC09M070290

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HEMGN Gene:

HEMGN (hemogen) is a protein-coding gene. Diseases associated with HEMGN include cleft palate, isolated, and cleft palate. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: HEMGN_HUMAN, Q9BXL5

Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced

megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the

nuclear factor-kappa B (NF-kB)

Gene Wiki entry for HEMGN Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NT_008470.19 NC_018920.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HEMGN gene promoter:
AREB6 AML1a FOXJ2 (long isoform) IRF-7A FOXJ2 Pax-4a NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HEMGN promoter sequence

Search SABiosciences Chromatin IP Primers for HEMGN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HEMGN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.33

HEMGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HEMGN gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M100689: view genomic region (about GC identifiers)

Start:	100,689,073 bp from pter	End:	100,707,138 bp from pter
Size:	18,066 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HEMGN_HUMAN, Q9BXL5 (See protein sequence)

Recommended Name: Hemogen

Size: 484 amino acids; 55341 Da

Subcellular location: Nucleus

Developmental stage: Expressed in fetal liver, kidney and brain

Sequence caution: Sequence=AAF67133.1; Type=Erroneous initiation; Sequence=AAF71041.1; Type=Erroneous initiation;

Sequence=AAG35488.1; Type=Erroneous initiation;

Secondary accessions: Q6XAR3 Q86XY5 Q9NPC0

Explore the universe of human proteins at neXtProt for HEMGN: NX_Q9BXL5

Explore proteomics data for HEMGN at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9BXL5

HEMGN Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_060907.2 NP_932095.1

ENSEMBL proteins:

ENSP00000259456

Human Recombinant Protein Products for HEMGN:

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	Cloud-Clone Corp. Proteins for HEMGN

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	IEA	--

HEMGN for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9BXL5

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HEMGN_HUMAN, Q9BXL5

Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced

megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the

nuclear factor-kappa B (NF-kB)

Induction: Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate

(TPA) (at protein level). Up-regulated in normal PBMCs by mitogens

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

HEMGN for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for HEMGN:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for HEMGN

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HEMGN

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		hsa-miR-3163 hsa-miR-181c hsa-miR-181a hsa-miR-551b* hsa-miR-181d hsa-miR-338-5p hsa-miR-493* hsa-miR-3941

		SwitchGear 3'UTR luciferase reporter plasmid: HEMGN 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEMGN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HEMGN

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/40 Interacting proteins for HEMGN (Q9BXL5^{1, 2} ENSP00000259456⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NPM1	P06748²	MINT-8373211 MINT-8373408 MINT-8373290 MINT-8373312 MINT-8373326 MINT-8373269 MINT-8373241
CBX5	P45973², ENSP00000209875⁴	MINT-7220149 STRING: ENSP00000209875
CTBP1	Q13363¹, ENSP00000290921⁴	EBI-3916399,EBI-908846 STRING: ENSP00000290921
ACTB	P60709²	MINT-7220149
CHAF1A	Q13111²	MINT-7220149

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0045667	regulation of osteoblast differentiation	IEA	--

HEMGN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HEMGN

Search CenterWatch for drugs/clinical trials and news about HEMGN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HEMGN gene (2 alternative transcripts):

NM_018437.4 NM_197978.2

Unigene Cluster for HEMGN:

Hemogen

Hs.176626 [show with all ESTs]

Unigene Representative Sequence: AY244805

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000259456

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		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate HEMGN (see all 11):
		hsa-miR-3163 hsa-miR-181c hsa-miR-181a hsa-miR-551b* hsa-miR-181d hsa-miR-338-5p hsa-miR-493* hsa-miR-3941

		SwitchGear 3'UTR luciferase reporter plasmid: HEMGN 3' UTR sequence

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Additional mRNA sequence:

AF116617.1 AF228713.2 AF306681.1 AF306682.1 AF306683.1 AF322875.1 AK292441.1 AL833094.1

AY244805.1 AY255672.1 BC048324.1

6 DOTS entries:

DT.420059 DT.100654530 DT.95272874 DT.121168421 DT.70103439 DT.40277937

24/73 AceView cDNA sequences (see all 73):

BX099803 AY255672 NM_018437 AA676259 AF306682 BP369905 NM_197978 AF322875

AA496130 AF306683 AF130060 AL597698 AI114455 BG571634 AL833094 BI772146

BC048324 AW965044 AW956520 AA431795 AA703264 AF306681 AA421187 BG941050

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HEMGN (see all 6) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b
SP1:					-		-		-		-		-
SP2:											-		-
SP3:													-
SP4:													-
SP5:

ECgene alternative splicing isoforms for HEMGN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HEMGN expression in normal human tissues (normalized intensities) HEMGN embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

HEMGN expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/6 selected tissues (see all 6) fully expand


Liver (Hepatobiliary System) fully expand to see all 2 entries
Mesothelial Cells Hepatic Mesenchyme
Liver Lobule

Testis (Reproductive System)
testis ; cells in seminiferus ducts

Bone (Muscoskeletal System)
Bone Marrow

Kidney (Urinary System)
Metanephric Mesenchyme Cells Metanephric Mesenchyme

Blood (Cardiovascular System)

See HEMGN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HEMGN

SOURCE GeneReport for Unigene cluster: Hs.176626

UniProtKB/Swiss-Prot: HEMGN_HUMAN, Q9BXL5

Tissue specificity: Expressed in hematopoietic precursor cells (at protein level). Detected in CD34+ and K-562 leukemia

cell lines (at protein level). Expressed in bone marrow, testis, thymus. Also expressed in thymus and thyroid tumors,

non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow

mononuclear cells (BMMCs) of patients with leukemia

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HEMGN gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hemgn^{1 , 5}	hemogen^{1, 5}	69.75(n)¹ 51.54(a)¹		4 (24.73 cM)⁵ 93966¹ NM_053149.2¹ NP_444379.1¹ 46393989⁵
chicken (Gallus gallus)	Aves	HEMGN⁶	hemogen	32(a)	1 ↔ 1	Z(70487737-70492461)
lizard (Anolis carolinensis)	Reptilia	HEMGN⁶	Uncharacterized protein	38(a)	1 ↔ 1	GL343544.1(215994-220919)

ENSEMBL Gene Tree for HEMGN (if available)
TreeFam Gene Tree for HEMGN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7030907^1,2	C,F,A,H	--	100688577(+)	`ATTTAC/TCATAT`	2	--	int¹		9		NS EA CSA WA NA	780
rs189912006^1,2		--	100688694(+)	`CTAGTA/TATATG`	2	--	int¹		0	--	--	--	--
rs181223097^1,2	C	--	100689026(+)	`TTAGAC/TAGGTC`	2	--	int¹		0	--	--	--	--
rs185822762^1,2		--	100689043(+)	`CCTCCA/GCAATT`	2	--	int¹		0	--	--	--	--
rs77357203^1,2	C	--	100689107(+)	`TTGTGA/CACAAA`	2	--	ut3¹		0	--	--	--	--
rs192066044^1,2		--	100689370(+)	`TAGGGA/GGGAAA`	2	--	ut3¹		0	--	--	--	--
rs77253143^1,2	C,F	--	100689375(+)	`GGGAAA/TACCAA`	2	--	ut3¹		1		WA	118
rs34825770^1,2	C	--	100689451(+)	`TACAT-/ACACACA`	2	--	ut3¹		0	--	--	--	--
rs72109422^1,2	C	--	100689451(+)	`TACAT-/ACA CACACACACA`	2	--	ut3¹		0	--	--	--	--
rs59177658^1,2	C	--	100689452(+)	`ACACA-/CACACAC`	2	--	ut3¹		2		NA CSA	4

HapMap Linkage Disequilibrium report for HEMGN (100689073 - 100707138 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for HEMGN: About this table

Variant ID	Type	Subtype	PubMed ID
nsv893611	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HEMGN

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HEMGN for disorders           About GeneDecksing

OMIM gene information: 610715    OMIM disorders: --

7 diseases for HEMGN:    About MalaCards

cleft palate, isolated cleft palate hodgkin's lymphoma non-hodgkin lymphoma

cleft lip thyroiditis leukemia

Genetic Association Database (GAD): HEMGN
Human Genome Epidemiology (HuGE) Navigator: HEMGN (2 documents)

Export disorders for HEMGN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HEMGN gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with HEMGN)

Utopia: connect your pdf to the dynamic
world of online information

Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis. (PubMed id 14648837)^{1, 2, 9} Yang L.V.... Li L. (2003)
Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)^{1, 4} Lowe J.K....Friedman J.M. (2009)
FOXE1 association with both isolated cleft lip with o r without cleft palate, and isolated cleft palate. (PubMed id 19779022)^{1, 4} Moreno L.M....Lidral A.C. (2009)
High expression of EDAG and its significance in AML. (PubMed id 15920494)^{1, 2} An L.-L....Song Y.-H. (2005)
EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B. (PubMed id 15332117)^{1, 2} Li C.Y.... Yang X.M. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells. (PubMed id 14730214)^{1, 2} Liu C.-C.... Ch'ang L.-Y. (2004)
Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. (PubMed id 11404085)^{1, 2} Yang L.V.... Li L. (2001)
Erythroid differentiation-associated gene interacts wi th NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis. (PubMed id 22712502)¹ Zhang M.J....Yang X.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55363	HGNC: 17509	AceView: HEMGN	Ensembl:ENSG00000136929	euGenes: HUgn55363
ECgene: HEMGN	H-InvDB: HEMGN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HEMGN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HEMGN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HEMGN gene:
Search GeneIP for patents involving HEMGN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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