Aliases for HEMGN Gene
Aliases for HEMGN Gene
External Ids for HEMGN Gene
- HGNC: 17509
- Entrez Gene: 55363
- Ensembl: ENSG00000136929
- OMIM: 610715
- UniProtKB: Q9BXL5
Previous GeneCards Identifiers for HEMGN Gene
- GC09M091514
- GC09M092432
- GC09M094146
- GC09M096068
- GC09M097768
- GC09M099729
- GC09M100689
- GC09M070290
Summaries for HEMGN Gene
GeneCards Summary for HEMGN Gene
HEMGN (Hemogen) is a Protein Coding gene. Diseases associated with HEMGN include Isolated Cleft Lip.
UniProtKB/Swiss-Prot for HEMGN Gene
-
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEMGN Gene
Genomics for HEMGN Gene
GeneHancer (GH) Regulatory Elements for HEMGN Gene
- Top Transcription factor binding sites by QIAGEN in the HEMGN gene promoter:
Regulatory Element Products
Genomic Locations for HEMGN Gene
- chr9:97,926,791-97,944,915
- (GRCh38/hg38)
- Size:
- 18,125 bases
- Orientation:
- Minus strand
- chr9:100,689,073-100,707,138
- (GRCh37/hg19)
Genomic View for HEMGN Gene
- Cytogenetic band:
-
- 9q22.33 by Ensembl
- 9q22.33 by Entrez Gene
- 9q22.33 by HGNC


RefSeq DNA sequence for HEMGN Gene
Proteins for HEMGN Gene
-
Protein details for HEMGN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BXL5-HEMGN_HUMAN
- Recommended name:
- Hemogen
- Protein Accession:
- Q9BXL5
- Q6XAR3
- Q86XY5
- Q9NPC0
Protein attributes for HEMGN Gene
- Size:
- 484 amino acids
- Molecular mass:
- 55341 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAF67133.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF71041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35488.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for HEMGN Gene
Post-translational modifications for HEMGN Gene
Other Protein References for HEMGN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HEMGN
-
Cloud-Clone Corp. Antibodies for HEMGN
- Invitrogen Antibodies for HEMGN
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-
Santa Cruz Biotechnology (SCBT) Antibodies for HEMGN
Protein Products
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-
Cloud-Clone Corp. Proteins for HEMGN
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-
Abcam proteins for HEMGN
Assay Products
-
Cloud-Clone Corp. Assay Kits for HEMGN
- antibodies-online: Search results for 8 available HEMGN Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for HEMGN Gene
Domains & Families for HEMGN Gene
Gene Families for HEMGN Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for HEMGN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HEMGN Gene
Function for HEMGN Gene
Molecular function for HEMGN Gene
- UniProtKB/Swiss-Prot Function:
- Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens.
Phenotypes From GWAS Catalog for HEMGN Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21988832 |
Phenotypes for HEMGN Gene
- MGI mutant phenotypes for HEMGN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HEMGN:
Animal Models for HEMGN Gene
- MGI Knock Outs for HEMGN:
-
- Hemgn tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HEMGN
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HEMGN gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for HEMGN
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- Applied Biological Materials CRISPR for HEMGN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEMGN
- GenScript: Design CRISPR guide RNA sequences for HEMGN
miRNA for HEMGN Gene
- miRTarBase miRNAs that target HEMGN
miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for HEMGN gene
Clone Products
- Sino Biological Human cDNA Clone for HEMGN
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- VectorBuilder custom plasmid, inducible vectors for HEMGN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEMGN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HEMGN gene related products
- orf clones - Search results for available HEMGN gene related products
- Applied Biological Materials Clones for HEMGN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HEMGN
-
ViGene Biosciences adenoviral particle packaged cDNA for HEMGN gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HEMGN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEMGN gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HEMGN Gene
Localization for HEMGN Gene
Subcellular locations from UniProtKB/Swiss-Prot for HEMGN Gene
- Nucleus.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HEMGN Gene
Pathways & Interactions for HEMGN Gene
Interacting Proteins for HEMGN Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007275 | multicellular organism development | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
GO:0045667 | regulation of osteoblast differentiation | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HEMGN Gene
Transcripts for HEMGN Gene
mRNA/cDNA for HEMGN Gene
- (5) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (73) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HEMGN
- genomics-online: gRNA clones - Search results for available HEMGN gene related products
- Applied Biological Materials CRISPR for HEMGN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEMGN
- GenScript: Design CRISPR guide RNA sequences for HEMGN
miRNA Products
- Search ViGene Biosciences for HEMGN
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HEMGN
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- genomics-online: shRNA clones - Search results for available HEMGN gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HEMGN gene
Clone Products
- Sino Biological Human cDNA Clone for HEMGN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HEMGN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEMGN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HEMGN gene related products
- orf clones - Search results for available HEMGN gene related products
- Applied Biological Materials Clones for HEMGN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - |
Expression for HEMGN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hematopoietic Stem Cells Liver Bud
- Hematopoietic Bone Marrow
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
- Hematopoietic Stem Cells Liver Bud
- Liver Lobule
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
- Bone (Muscoskeletal System)
-
Spleen (Hematopoietic System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for HEMGN Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HEMGN Gene
NURSA nuclear receptor signaling pathways regulating expression of HEMGN Gene:
HEMGNSOURCE GeneReport for Unigene cluster for HEMGN Gene:
Hs.176626mRNA Expression by UniProt/SwissProt for HEMGN Gene:
Q9BXL5-HEMGN_HUMANEvidence on tissue expression from TISSUES for HEMGN Gene
- Bone marrow(4.5)
- Nervous system(4.1)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for HEMGN
-
OriGene qPCR primer pairs for HEMGN
- genomics-online: primer clones - Search results for available HEMGN gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEMGN Gene
Orthologs for HEMGN Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HEMGN 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | HEMGN 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | HEMGN 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Hemgn 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Hemgn 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | HEMGN 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | HEMGN 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | HEMGN 34 |
|
OneToOne |
- Species where no ortholog for HEMGN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HEMGN Gene
No data available for Paralogs for HEMGN Gene
Variants for HEMGN Gene
SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000092327 | -- | 97,944,167(-) | T/A | genic_upstream_transcript_variant, intron_variant | |
rs1000272795 | -- | 97,941,226(-) | A/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000736294 | -- | 97,936,001(-) | T/A | intron_variant | |
rs1000803091 | -- | 97,928,045(-) | G/C/T | intron_variant | |
rs1000877576 | -- | 97,944,528(-) | G/T | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1048135 | CNV | loss | 25217958 |
nsv472589 | CNV | novel sequence insertion | 20440878 |
Additional Variant Information for HEMGN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HEMGN
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEMGN Gene
Disorders for HEMGN Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
isolated cleft lip |
|
|
Additional Disease Information for HEMGN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HEMGN Gene
Publications for HEMGN Gene
- Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis. (PMID: 14648837) Yang LV … Li L (Developmental dynamics : an official publication of the American Association of Anatomists 2003) 3 4 22 58
- Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe JK … Friedman JM (PLoS genetics 2009) 3 44 58
- FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. (PMID: 19779022) Moreno LM … Lidral AC (Human molecular genetics 2009) 3 44 58
- High expression of EDAG and its significance in AML. (PMID: 15920494) An LL … Song YH (Leukemia 2005) 3 4 58
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
Products for HEMGN Gene
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- Invitrogen Antibodies for HEMGN
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- VectorBuilder custom plasmid, inducible vectors for HEMGN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEMGN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available HEMGN related products ranked by validation data
- antibodies-online: Search results for 8 available HEMGN Elisa Kits ranked by validation data
- Compare Top HEMGN Elisa Kits
- Quality Products:
- antibodies-online: Search results for available HEMGN related products ranked by validation data
- Search GeneTex for Antibodies for HEMGN
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- ViGene Biosciences adenoviral particle packaged cDNA for HEMGN gene
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- Horizon Cell Lines for HEMGN
- genomics-online: cdna clones - Search results for available HEMGN gene related products
- orf clones - Search results for available HEMGN gene related products
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Sources for HEMGN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew