HEMGN Gene

Aliases
for HEMGN gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC09M091514 GC09M092432 GC09M094146 GC09M096068 GC09M097768 GC09M099729 GC09M070290

Summaries
for HEMGN gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for HEMGN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000009.11  NT_008470.20  NC_018920.2  

SwitchGear Promoter luciferase reporter plasmid: HEMGN promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HEMGN

HEMGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M100689:  view genomic region     (about GC identifiers)

Proteins
for HEMGN gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for HEMGN: NX_Q9BXL5

Explore proteomics data for HEMGN at MOPED

Post-translational modifications: 

HEMGN Human Recombinant Protein Products:

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	antibodies-online peptides for HEMGN

HEMGN Antibody Products:

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	antibodies-online antibodies for HEMGN (26 products)

HEMGN Assay Products:

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	Search eBioscience for ELISAs for HEMGN
	antibodies-online kits for HEMGN (10 products)

Domains /
Families
for HEMGN gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9BXL5

Function
for HEMGN gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for HEMGN

miRNA Products:		miRTarBase miRNAs that target HEMGN: hsa-mir-148b-3p (MIRT019451)
		Block miRNA regulation of human, mouse, rat HEMGN using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate HEMGN (see all 11):
		hsa-miR-3163 hsa-miR-181c hsa-miR-181a hsa-miR-551b* hsa-miR-181d hsa-miR-338-5p hsa-miR-493* hsa-miR-3941
		SwitchGear 3'UTR luciferase reporter plasmid: HEMGN 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HEMGN
		Predesigned siRNA for gene silencing in human, mouse, rat HEMGN

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HEMGN

Clone Products:		OriGene clones in human, mouse for HEMGN (see all 13) OriGene ORF clones in mouse, rat for HEMGN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HEMGN (NM_018437)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HEMGN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HEMGN

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		Browse ESI BIO Cell Lines and PureStem Progenitors for HEMGN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEMGN

Flow Cytometry Products:

eBioscience FlowRNA Probe Sets ( VA1-10051) for HEMGN

Localization
for HEMGN gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	3
plasma membrane	3

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for HEMGN gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for HEMGN gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for HEMGN gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for HEMGN gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HEMGN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Liver (Hepatobiliary System)    fully expand to see all 3 entries
Hematopoietic Stem Cells Liver Bud
Liver Lobule
Blood (Cardiovascular System)    fully expand to see all 2 entries
Hematopoietic Stem Cells Liver Bud
Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
Muscle Progenitor Cells Mandibular Arch Muscles
Bone (Muscoskeletal System)
Bone Marrow
Kidney (Urinary System)
Metanephric Mesenchyme Cells Metanephric Mesenchyme

Primer Products:		OriGene qPCR primer pairs and template standards for HEMGN OriGene qSTAR qPCR primer pairs in human, mouse for HEMGN
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HEMGN
		QuantiTect SYBR Green Assays in human, mouse, rat HEMGN
		QuantiFast Probe-based Assays in human, mouse, rat HEMGN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HEMGN

Orthologs
for HEMGN gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for HEMGN gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for HEMGN gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HEMGN (see all 405)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs70309071,2	C,F,A,H	--	100688577(+)	ATTTAC/TCATAT	2	--	int1		9		NS EA CSA WA NA	780
rs1899120061,2		--	100688694(+)	CTAGTA/TATATG	2	--	int1		0	--	--	--	--
rs1812230971,2	C	--	100689026(+)	TTAGAC/TAGGTC	2	--	int1		0	--	--	--	--
rs1858227621,2		--	100689043(+)	CCTCCA/GCAATT	2	--	int1		0	--	--	--	--
rs773572031,2	C	--	100689107(+)	TTGTGA/CACAAA	2	--	ut31		0	--	--	--	--
rs1920660441,2		--	100689370(+)	TAGGGA/GGGAAA	2	--	ut31		0	--	--	--	--
rs772531431,2	C,F	--	100689375(+)	GGGAAA/TACCAA	2	--	ut31		1		WA	118
rs348257701,2	C	--	100689451(+)	TACAT-/ACACACA	2	--	ut31		0	--	--	--	--
rs721094221,2	C	--	100689451(+)	TACAT-/ACA       CACACACACA	2	--	ut31		0	--	--	--	--
rs591776581,2	C	--	100689452(+)	ACACA-/CACACAC	2	--	ut31		2		NA CSA	4

HapMap Linkage Disequilibrium report for HEMGN (100689073 - 100707138 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for HEMGN:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv893611	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HEMGN

DNA2.0 Custom Variant and Variant Library Synthesis for HEMGN

Disorders / Diseases
for HEMGN gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for HEMGN gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HEMGN gene, integrated from 10 sources (see all 22): (articles sorted by number of sources associating them with HEMGN)

Utopia: connect your pdf to the dynamic world of online information

1. Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis. (PubMed id 14648837)^{1, 2, 9} Yang L.V.... Li L. (Dev. Dyn. 2003)
2. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)^{1, 4} Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
3. FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. (PubMed id 19779022)^{1, 4} Moreno L.M....Lidral A.C. (Hum. Mol. Genet. 2009)
4. High expression of EDAG and its significance in AML. (PubMed id 15920494)^{1, 2} An L.-L....Song Y.-H. (Leukemia 2005)
5. EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B. (PubMed id 15332117)^{1, 2} Li C.Y.... Yang X.M. (Cell Death Differ. 2004)
6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (Nature 2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
8. Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells. (PubMed id 14730214)^{1, 2} Liu C.-C.... Ch'ang L.-Y. (J. Biomed. Sci. 2004)
9. Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. (PubMed id 11404085)^{1, 2} Yang L.V.... Li L. (Mech. Dev. 2001)
10. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PubMed id 23436708)² Liu M....Sha J. (Proteomics 2013)

External Searches for HEMGN gene

Genome Databases showing HEMGN gene

Other Databases showing HEMGN gene

Specialized Databases showing HEMGN gene

Products
for HEMGN gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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