Aliases for HELZ2 Gene
Aliases for HELZ2 Gene
- Helicase With Zinc Finger 2 2 3 5
- Helicase With Zinc Finger 2, Transcriptional Coactivator 2 3 4
- Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 285 KDa Protein 3 4
- PPAR-Gamma DNA-Binding Domain-Interacting Protein 1 3 4
- PPAR-Alpha-Interacting Complex Protein 285 3 4
- PPARG-DBD-Interacting Protein 1 2 3
- ATP-Dependent Helicase PRIC285 3 4
- PRIC285 3 4
- PDIP1 3 4
- Peroxisomal Proliferator-Activated Receptor Alpha-Interacting Cofactor Complex, 285 KD Subunit 3
- Peroxisomal Proliferator Activated Receptor A Interacting Complex 285 2
External Ids for HELZ2 Gene
- HGNC: 30021
- Entrez Gene: 85441
- Ensembl: ENSG00000130589
- OMIM: 611265
- UniProtKB: Q9BYK8
Previous GeneCards Identifiers for HELZ2 Gene
- GC20M062190
Summaries for HELZ2 Gene
-
The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HELZ2 Gene
HELZ2 (Helicase With Zinc Finger 2) is a Protein Coding gene. Among its related pathways are Mitochondrial Gene Expression and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include poly(A) RNA binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is UPF1.
UniProtKB/Swiss-Prot for HELZ2 Gene
-
Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELZ2 Gene
Genomics for HELZ2 Gene
Regulatory Elements for HELZ2 Gene
Enhancers for HELZ2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HELZ2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HELZ2 Gene
- Chromosome:
- 20
- Start:
- 63,558,086 bp from pter
- End:
- 63,574,239 bp from pter
- Size:
- 16,154 bases
- Orientation:
- Minus strand
Genomic View for HELZ2 Gene
Genes around HELZ2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.33 by Ensembl
- 20q13.33 by Entrez Gene
- 20q13.33 by HGNC
HELZ2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HELZ2 Gene
Proteins for HELZ2 Gene
-
Protein details for HELZ2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BYK8-HELZ2_HUMAN
- Recommended name:
- Helicase with zinc finger domain 2
- Protein Accession:
- Q9BYK8
- Q3C2G2
- Q4VXQ1
- Q8TEF3
- Q96ND3
- Q9C094
Protein attributes for HELZ2 Gene
- Size:
- 2649 amino acids
- Molecular mass:
- 294651 Da
- Quaternary structure:
-
- Interacts with PPARA (via DNA-binding domain) and PPARG; the interaction stimulates the transcriptional activity of PPARA and PPARG. Interacts with THRAP3; the interaction is direct and HELZ2 and THRAP3 synergistically enhance the transcriptional activity of PPARG. It is probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC).
- SequenceCaution:
-
- Sequence=BAB70969.1; Type=Frameshift; Positions=2206; Evidence={ECO:0000305};
Protein Expression for HELZ2 Gene
Post-translational modifications for HELZ2 Gene
Other Protein References for HELZ2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HELZ2
-
Abcam antibodies for HELZ2
- Invitrogen Antibodies for HELZ2
- antibodies-online Antibodies for HELZ2: See all 12
- Search GeneTex for Antibodies for HELZ2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HELZ2
- Origene Custom Protein Services for HELZ2
- Novus Biologicals proteins for HELZ2
- Search GeneTex for Proteins for HELZ2
-
Abcam proteins for HELZ2
Assay Products
No data available for DME Specific Peptides for HELZ2 Gene
Domains & Families for HELZ2 Gene
Gene Families for HELZ2 Gene
Protein Domains for HELZ2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HELZ2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BYK8UniProtKB/Swiss-Prot:
HELZ2_HUMAN :- Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG.
- Belongs to the DNA2/NAM7 helicase family.
- Domain:
-
- Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG.
- Family:
-
- Belongs to the DNA2/NAM7 helicase family.
Function for HELZ2 Gene
Molecular function for HELZ2 Gene
- UniProtKB/Swiss-Prot Function:
- Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.
Enzyme Numbers (IUBMB) for HELZ2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16239304 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for HELZ2 Gene
- MGI mutant phenotypes for HELZ2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HELZ2:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Lamellipodia cells
- Strongly decreased CFP-tsO45G cell surface transport
- Increased G1 DNA content
- Decreased cell number
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased Nanog expression
Animal Models for HELZ2 Gene
- MGI Knock Outs for HELZ2:
-
- Helz2 tm1Tesa
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HELZ2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HELZ2 gene
- Search ViGene Biosciences for HELZ2
CRISPR Products
-
OriGene CRISPR knockouts for HELZ2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HELZ2
- GenScript: Design CRISPR guide RNA sequences for HELZ2
miRNA for HELZ2 Gene
- miRTarBase miRNAs that target HELZ2
miRNA Products
- Search ViGene Biosciences for HELZ2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HELZ2
- Browse OriGene Inhibitory RNA Products For HELZ2
-
ViGene Biosciences ready-to-package AAV shRNAs for HELZ2 gene
Cell Line Products
-
Horizon Cell Lines for HELZ2
-
ViGene Biosciences adenoviral particle packaged cDNA for HELZ2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HELZ2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HELZ2 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HELZ2 Gene
Localization for HELZ2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HELZ2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016020 | membrane | IDA | 19946888 |
Pathways & Interactions for HELZ2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 3 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | ||
| 4 | Gene Expression |
.48
|
|
| 5 | Metabolism |
.37
|
|
Pathways by source for HELZ2 Gene
Interacting Proteins for HELZ2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0019216 | regulation of lipid metabolic process | TAS | -- |
| GO:0044255 | cellular lipid metabolic process | TAS | -- |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IDA | 16239304 |
No data available for SIGNOR curated interactions for HELZ2 Gene
Transcripts for HELZ2 Gene
mRNA/cDNA for HELZ2 Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (97) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HELZ2 Gene
- Helicase with zinc finger 2, transcriptional coactivator:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HELZ2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HELZ2
- GenScript: Design CRISPR guide RNA sequences for HELZ2
miRNA Products
- Search ViGene Biosciences for HELZ2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HELZ2
- Browse OriGene Inhibitory RNA Products For HELZ2
-
ViGene Biosciences ready-to-package AAV shRNAs for HELZ2 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
Expression for HELZ2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for HELZ2 Gene
This gene is overexpressed in Whole Blood (x5.5).
This gene is overexpressed in Breast (25.0), Serum (17.2), and Synovial fluid (14.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HELZ2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HELZ2 Gene:
HELZ2SOURCE GeneReport for Unigene cluster for HELZ2 Gene:
Hs.517180mRNA Expression by UniProt/SwissProt for HELZ2 Gene:
Q9BYK8-HELZ2_HUMAN
Tissue specificity:
Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta.
Evidence on tissue expression from TISSUES for HELZ2 Gene
- Liver(4.2)
- Spleen(4.2)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for HELZ2
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HELZ2 Gene
Orthologs for HELZ2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HELZ2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HELZ2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Helz2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Helz2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | HELZ2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HELZ2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HELZ2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101733680 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC562461 34 |
|
||
| HELZ2 (1 of 3) 35 |
|
OneToMany | |||
| helz2 35 |
|
OneToMany | |||
| HELZ2 (2 of 3) 35 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.71 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NAM7 35 |
|
OneToMany |
- Species where no ortholog for HELZ2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HELZ2 Gene
Variants for HELZ2 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000070693 | -- | 63,566,417(+) | GCCTA(A/G)GTCCC | reference, synonymous-codon | |
| rs1000230439 | -- | 63,558,447(+) | CAGGC(A/G)GTGAT | utr-variant-3-prime | |
| rs1000364542 | -- | 63,562,883(+) | GCCCC(C/T)GCGGC | reference, missense | |
| rs1000568893 | -- | 63,564,420(+) | CGGGT(A/G)CTGCC | reference, missense | |
| rs1000708819 | -- | 63,559,958(+) | CCGCG(C/T)GACAG | reference, missense |
Residual Variation Intolerance Score:
99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.40;
95.43% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HELZ2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELZ2 Gene
Disorders for HELZ2 Gene
Relevant External Links for HELZ2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HELZ2
No disorders were found for HELZ2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HELZ2 Gene
Publications for HELZ2 Gene
- Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the DNA-binding domain of peroxisome proliferator-activated receptor gamma. (PMID: 16239304) Tomaru T. … Mori M. (Endocrinology 2006) 2 3 4 22 64
- Identification of a transcriptionally active peroxisome proliferator- activated receptor alpha-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. (PMID: 12189208) Surapureddi S. … Reddy J.K. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 64
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
- THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. (PMID: 23525231) Katano-Toki A. … Mori M. (Mol. Endocrinol. 2013) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for HELZ2 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for HELZ2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HELZ2
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- OriGene qPCR primer pairs for HELZ2
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- GenScript: Next-day shipping cDNA ORF clone for HELZ2 in any vector
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- GenScript: Design CRISPR guide RNA sequences for HELZ2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Sino Biological Transfection Reagents
- Novus Biologicals proteins for HELZ2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HELZ2
- Abcam proteins for HELZ2
- Search for Assays for HELZ2 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ViGene Biosciences adenoviral particle packaged cDNA for HELZ2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HELZ2 gene
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- Search ViGene Biosciences for HELZ2
- Search Santa Cruz Biotechnology (SCBT) for HELZ2 Antibodies
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- Santa Cruz Biotechnology (SCBT) CRISPR for HELZ2
- Horizon Cell Lines for HELZ2
- Cyagen custom Knockout/knockin (KOKI) mouse models for HELZ2
- VectorBuilder custom plasmid, inducible vectors for HELZ2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HELZ2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HELZ2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer