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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HELZ2 Gene

protein-coding   GIFtS: 46
GCID: GC20M062190

Helicase With Zinc Finger 2, Transcriptional Coactivator

  Search for HELZ2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Helicase With Zinc Finger 2, Transcriptional Coactivator1 2 3     PDIP-12
Peroxisomal Proliferator Activated Receptor A Interacting Complex 2851 2     Helicase With Zinc Finger Domain 22
PPARG-DBD-Interacting Protein 11 2     Peroxisomal Proliferator-Activated Receptor A Interacting Complex 2852
Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 285 KDa
Protein2 3
     Peroxisomal Proliferator-Activated Receptor Alpha-Interacting Cofactor
Complex, 285 KD Subunit2
PDIP12 3     PPAR Gamma DBD-Interacting Protein 12
PRIC2852 3     PPARgamma-DNA-Binding Domain-Interacting Protein12
ATP-Dependent Helicase PRIC2852 3     PRIC Complex2
PPAR-Alpha-Interacting Complex Protein 2852 3     EC 3.6.4.-3
PPAR-Gamma DBD-Interacting Protein 12 3     KIAA17693
PPAR-Gamma DNA-Binding Domain-Interacting Protein 12 3     

External Ids:    HGNC: 300211   Entrez Gene: 854412   Ensembl: ENSG000001305897   OMIM: 6112655   UniProtKB: Q9BYK83   

Export aliases for HELZ2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HELZ2 Gene:
The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated
receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the
peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7
helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for HELZ2 Gene: 
HELZ2 (helicase with zinc finger 2, transcriptional coactivator) is a protein-coding gene. Among its related super-pathways are Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolic pathways. GO annotations related to this gene include RNA binding and helicase activity. An important paralog of this gene is HELZ.

UniProtKB/Swiss-Prot: HELZ2_HUMAN, Q9BYK8
Function: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA,
PPARG, THRA, THRB and RXRA

Gene Wiki entry for HELZ2 (PRIC285) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011333.6  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HELZ2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHELZ2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HELZ2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HELZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

HELZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HELZ2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062190:  view genomic region     (about GC identifiers)

Start:
62,189,439 bp from pter      End:
62,205,592 bp from pter
Size:
16,154 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HELZ2_HUMAN, Q9BYK8 (See protein sequence)
Recommended Name: Helicase with zinc finger domain 2  
Size: 2649 amino acids; 294651 Da
Subunit: Interacts with PPARA (via DNA-binding domain); the interaction stimulates the transcriptional activity of
PPARA. It is probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC)
Subcellular location: Nucleus
Caution: PubMed:12189208 experiments have been carried out partly in rat and partly in human
Sequence caution: Sequence=BAB70969.1; Type=Frameshift; Positions=2206;
Secondary accessions: Q3C2G2 Q4VXQ1 Q8TEF3 Q96ND3 Q9C094
Alternative splicing: 3 isoforms:  Q9BYK8-1   Q9BYK8-2   Q9BYK8-4   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HELZ2: NX_Q9BYK8

Explore proteomics data for HELZ2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BYK8

  • HELZ2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HELZ2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001032412.2  NP_208384.3  

    ENSEMBL proteins: 
     ENSP00000393257   ENSP00000417401  
    Reactome Protein details: Q9BYK8
    Human Recombinant Protein Products for HELZ2: 
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    Novus Biologicals HELZ2 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    HELZ2 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR022966 RNase_II/R_CS
     IPR015880 Znf_C2H2-like
     IPR026855 PRIC285
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q9BYK8

    ProtoNet protein and cluster: Q9BYK8

    1 Blocks protein domain: IPB001900 Ribonuclease II

    UniProtKB/Swiss-Prot: HELZ2_HUMAN, Q9BYK8
    Domain: Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG
    Similarity: Belongs to the DNA2/NAM7 helicase family
    Similarity: Contains 1 C2H2-type zinc finger


    HELZ2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HELZ2_HUMAN, Q9BYK8
    Function: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA,
    PPARG, THRA, THRB and RXRA

         Enzyme Number (IUBMB): EC 3.6.4.-1

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity NAS--
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity IEA--
    GO:0004540ribonuclease activity IEA--
         
    HELZ2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HELZ2:
     Decreased Wnt reporter activit  Elongated cells with protrusio  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HELZ2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HELZ2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HELZ2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HELZ2 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidHELZ2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HELZ2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3Axon guidance
    Developmental Biology0.69
    4Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for HELZ2 (see all 6)
        Developmental Biology
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Transcriptional Regulation of White Adipocyte Differentiation
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism



    HELZ2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HELZ2

    3 Interacting proteins for HELZ2 (Q9BYK83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823I2D: score=2 
    PPARAQ078693I2D: score=1 
    PPARGP372313I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA16239304

    HELZ2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HELZ2

    Search CenterWatch for drugs/clinical trials and news about HELZ2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HELZ2 gene (2 alternative transcripts): 
    NM_001037335.2  NM_033405.3  

    Unigene Cluster for HELZ2:

    Helicase with zinc finger 2, transcriptional coactivator
    Hs.517180  [show with all ESTs]
    Unigene Representative Sequence: NM_001037335
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427522(uc002yfl.1) ENST00000478861 ENST00000467148(uc002yfm.2)
    ENST00000479540 ENST00000370082(uc002yfn.2)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidHELZ2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HELZ2

    Additional mRNA sequence: 

    AB051556.2 AB201715.1 AB232667.1 AF517673.1 AK023724.1 AK055611.1 AK074171.1 BC036883.1 
    BC104974.1 BC112023.1 BC150283.1 

    7 DOTS entries:

    DT.102826711  DT.75168123  DT.102820312  DT.70102086  DT.120823388  DT.40218929  DT.97841213 

    24/97 AceView cDNA sequences (see all 97):

    AJ713391 BQ962308 BE279793 BX092705 AK074171 BX479723 BQ441066 AI613183 
    AW732944 NM_033405 BQ053506 BU859751 AI805682 BU538654 BF591176 CF121770 
    BU540623 CD635077 BQ054172 AW501525 CD635079 BG324399 BU844898 BG822608 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HELZ2 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21
    SP1:                                                              -                                                                                             
    SP2:                                                                                                                                -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -     -     -     -     -     -         
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for HELZ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HELZ2 expression in normal human tissues (normalized intensities)      HELZ2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HELZ2 Expression
    About this image


    HELZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Liver (Hepatobiliary System)

    See HELZ2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HELZ2

    SOURCE GeneReport for Unigene cluster: Hs.517180

    UniProtKB/Swiss-Prot: HELZ2_HUMAN, Q9BYK8
    Tissue specificity: Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver,
    kidney, lung, peripheral blood and placenta

        SABiosciences Custom PCR Arrays for HELZ2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HELZ2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Helz25
    BC0067791
    cDNA sequence BC0067791, 5 74.37(n)1
    70.01(a)1
      2 (103.63 cM)5
    2290031  NM_183162.21  NP_898985.21 
     1812276165 
    chicken
    (Gallus gallus)
    Aves HELZ21 helicase with zinc finger 2, transcriptional coactivator 59.81(n)
    51.5(a)
      419265  XM_417438.2  XP_417438.2 
    lizard
    (Anolis carolinensis)
    Reptilia HELZ26
    helicase with zinc finger 2, transcriptional coact...
    44(a)
    1 ↔ 1
    GL343401.1(582159-642154)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5624611 peroxisomal proliferator-activated receptor A-interacting more 48.37(n)
    42.11(a)
      562461  XM_003198847.1  XP_003198895.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eri-76
    Protein ERI-7
    17(a)
    1 → many
    I(4451197-4456805)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HCS16
    Hexameric DNA polymerase alpha-associated DNA heli...
    16(a)
    1 → many
    XI(405190-407241)


    ENSEMBL Gene Tree for HELZ2 (if available)
    TreeFam Gene Tree for HELZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HELZ2 gene
    HELZ2  MOV10L12  MOV102  UPF12  C4orf212  
    2 SIMAP similar genes for HELZ2 using alignment to 1 protein entry:     HELZ2_HUMAN:
    PDIP1beta    PRIC285

    HELZ2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/980 SNPs in HELZ2 are shown (see all 980)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61224761,2
    C,F,H--62189030(+) GGCTGG/ATGGCC 2 -- ds500118Minor allele frequency- A:0.39NS EA NA 2224
    rs61224771,2
    C,F,A,H--62189093(+) GTGGCC/TTGTCC 2 -- ds500121Minor allele frequency- T:0.43NS EA NA WA CSA 2156
    rs1503559451,2
    C--62189151(+) ACACCA/GGCCCT 2 -- ds50010--------
    rs1380762351,2
    --62189190(+) TCCTGC/TGCCCA 2 -- ds50010--------
    rs1836964521,2
    --62189300(+) CTCCAC/TGGCCG 2 -- ds50010--------
    rs1878007011,2
    C--62189336(+) CCCTGC/TGCCCA 2 -- ds50010--------
    rs1495451251,2
    --62189379(+) AACTGC/TGTACC 2 -- ds50010--------
    rs1442287421,2
    --62189441(+) AAGTGA/GGAAGA 2 -- ut310--------
    rs1911070241,2
    --62189459(+) GAGTGA/GTTTTA 2 -- ut310--------
    rs787787521,2
    C,F--62189604(+) ACATAC/AAGCCG 2 -- ut311Minor allele frequency- A:0.10WA 118

    HapMap Linkage Disequilibrium report for HELZ2 (62189439 - 62205592 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HELZ2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HELZ2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HELZ2 for disorders           About MalaCards
    OMIM gene information: 611265    OMIM disorders: --


    HELZ2 for disorders           About GeneDecksing


    Export disorders for HELZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HELZ2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with HELZ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the DNA-binding domain of peroxisome proliferator-activated receptor gamma. (PubMed id 16239304)1, 2, 3, 9 Tomaru T.... Mori M. (2006)
    2. Identification of a transcriptionally active peroxisome proliferator- activated receptor alpha-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. (PubMed id 12189208)1, 2, 3 Surapureddi S....Reddy J.K. (2002)
    3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Genetics of gene expression in primary immune cells id entifies cell type-specific master regulators and roles of HLA alleles. (PubMed id 22446964)1 Fairfax B.P....Knight J.C. (2012)
    8. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85441 HGNC: 30021 AceView: PRIC285 Ensembl:ENSG00000130589 euGenes: HUgn85441
    ECgene: HELZ2 H-InvDB: HELZ2

    (According to HUGE)
    About This Section
    HUGE: KIAA1769

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HELZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HELZ2 gene:
    Search GeneIP for patents involving HELZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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