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Aliases for HELZ2 Gene

Aliases for HELZ2 Gene

  • Helicase With Zinc Finger 2, Transcriptional Coactivator 2 3 4
  • PRIC285 3 4 6
  • PDIP1 3 4 6
  • Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 285 KDa Protein 3 4
  • Peroxisomal Proliferator Activated Receptor A Interacting Complex 285 2 3
  • PPAR-Gamma DNA-Binding Domain-Interacting Protein 1 3 4
  • PPAR-Alpha-Interacting Complex Protein 285 3 4
  • PPAR-Gamma DBD-Interacting Protein 1 3 4
  • PPARG-DBD-Interacting Protein 1 2 3
  • ATP-Dependent Helicase PRIC285 3 4
  • KIAA1769 4 6
  • Peroxisomal Proliferator-Activated Receptor Alpha-Interacting Cofactor Complex, 285 KD Subunit 3
  • Peroxisomal Proliferator-Activated Receptor A Interacting Complex 285 3
  • PPARgamma-DNA-Binding Domain-Interacting Protein1 3
  • PPAR Gamma DBD-Interacting Protein 1 3
  • Helicase With Zinc Finger Domain 2 3
  • PRIC Complex 3
  • EC 3.6.4.- 4
  • PDIP-1 3

External Ids for HELZ2 Gene

Previous GeneCards Identifiers for HELZ2 Gene

  • GC20M062190

Summaries for HELZ2 Gene

Entrez Gene Summary for HELZ2 Gene

  • The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HELZ2 Gene

HELZ2 (Helicase With Zinc Finger 2, Transcriptional Coactivator) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include RNA binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is UPF1.

UniProtKB/Swiss-Prot for HELZ2 Gene

  • Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.

Gene Wiki entry for HELZ2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELZ2 Gene

Genomics for HELZ2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HELZ2 Gene

Start:
63,558,086 bp from pter
End:
63,574,239 bp from pter
Size:
16,154 bases
Orientation:
Minus strand

Genomic View for HELZ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HELZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELZ2 Gene

No data available for Regulatory Elements for HELZ2 Gene

Proteins for HELZ2 Gene

  • Protein details for HELZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYK8-HELZ2_HUMAN
    Recommended name:
    Helicase with zinc finger domain 2
    Protein Accession:
    Q9BYK8
    Secondary Accessions:
    • Q3C2G2
    • Q4VXQ1
    • Q8TEF3
    • Q96ND3
    • Q9C094

    Protein attributes for HELZ2 Gene

    Size:
    2649 amino acids
    Molecular mass:
    294651 Da
    Quaternary structure:
    • Interacts with PPARA (via DNA-binding domain) and PPARG; the interaction stimulates the transcriptional activity of PPARA and PPARG. Interacts with THRAP3; the interaction is direct and HELZ2 and THRAP3 synergistically enhance the transcriptional activity of PPARG. It is probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC).
    SequenceCaution:
    • Sequence=BAB70969.1; Type=Frameshift; Positions=2206; Evidence={ECO:0000305};

    Alternative splice isoforms for HELZ2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HELZ2 Gene

Proteomics data for HELZ2 Gene at MOPED

Post-translational modifications for HELZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HELZ2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HELZ2 Gene

Domains for HELZ2 Gene

Protein Domains for HELZ2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYK8

UniProtKB/Swiss-Prot:

HELZ2_HUMAN :
  • Q9BYK8
Domain:
  • Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG.
Family:
  • Belongs to the DNA2/NAM7 helicase family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with HELZ2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for HELZ2 Gene

Function for HELZ2 Gene

Molecular function for HELZ2 Gene

UniProtKB/Swiss-Prot Function:
Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.

Enzyme Numbers (IUBMB) for HELZ2 Gene

Gene Ontology (GO) - Molecular Function for HELZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 16239304
GO:0005524 ATP binding IEA --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 16239304
genes like me logo Genes that share ontologies with HELZ2: view

Phenotypes for HELZ2 Gene

genes like me logo Genes that share phenotypes with HELZ2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HELZ2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HELZ2 Gene

Localization for HELZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HELZ2 Gene

Gene Ontology (GO) - Cellular Components for HELZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HELZ2: view

No data available for Subcellular locations from COMPARTMENTS for HELZ2 Gene

Pathways for HELZ2 Gene

genes like me logo Genes that share pathways with HELZ2: view

Gene Ontology (GO) - Biological Process for HELZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 16239304
genes like me logo Genes that share ontologies with HELZ2: view

Transcripts for HELZ2 Gene

Unigene Clusters for HELZ2 Gene

Helicase with zinc finger 2, transcriptional coactivator:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HELZ2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HELZ2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21
SP1: -
SP2: -
SP3:
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for HELZ2 Gene

GeneLoc Exon Structure for
HELZ2
ECgene alternative splicing isoforms for
HELZ2

Expression for HELZ2 Gene

mRNA expression in normal human tissues for HELZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HELZ2 Gene

This gene is overexpressed in Whole Blood (5.5).

Protein differential expression in normal tissues for HELZ2 Gene

This gene is overexpressed in Breast (25.0), Serum (17.2), and Synovial fluid (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HELZ2 Gene

SOURCE GeneReport for Unigene cluster for HELZ2 Gene Hs.517180

mRNA Expression by UniProt/SwissProt for HELZ2 Gene

Q9BYK8-HELZ2_HUMAN
Tissue specificity: Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta.
genes like me logo Genes that share expressions with HELZ2: view

In Situ Assay Products

No data available for Expression partners for HELZ2 Gene

Orthologs for HELZ2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HELZ2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HELZ2 35
  • 80.61 (n)
  • 73.05 (a)
HELZ2 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Helz2 35
  • 74.98 (n)
  • 70.7 (a)
Helz2 16
Helz2 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HELZ2 35
  • 98.83 (n)
  • 98.79 (a)
HELZ2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Helz2 35
  • 75.58 (n)
  • 71.35 (a)
oppossum
(Monodelphis domestica)
Mammalia HELZ2 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves HELZ2 35
  • 59.67 (n)
  • 51.33 (a)
HELZ2 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HELZ2 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733680 35
  • 55.12 (n)
  • 41.83 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562461 35
  • 48.63 (n)
  • 41.89 (a)
helz2 36
  • 37 (a)
OneToMany
HELZ2 (1 of 3) 36
  • 47 (a)
OneToMany
HELZ2 (2 of 3) 36
  • 35 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.71 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 36
  • 22 (a)
OneToMany
Species with no ortholog for HELZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HELZ2 Gene

ENSEMBL:
Gene Tree for HELZ2 (if available)
TreeFam:
Gene Tree for HELZ2 (if available)

Paralogs for HELZ2 Gene

Paralogs for HELZ2 Gene

Selected SIMAP similar genes for HELZ2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HELZ2: view

Variants for HELZ2 Gene

Sequence variations from dbSNP and Humsavar for HELZ2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs310627 -- 63,558,992(+) TCCTT(A/G)CACTG utr-variant-3-prime
rs310628 -- 63,559,059(+) AGGAG(A/G)AGCAA utr-variant-3-prime
rs310629 -- 63,562,061(+) CCGGC(A/G)TGGGC intron-variant
rs310630 -- 63,563,734(+) TAGGC(A/G)GAGCC synonymous-codon, reference
rs310631 - 63,564,900(-) TGAGG(G/T)TGCCC reference, missense

Relevant External Links for HELZ2 Gene

HapMap Linkage Disequilibrium report
HELZ2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HELZ2 Gene

Disorders for HELZ2 Gene

No disorders were found for HELZ2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HELZ2 Gene

Publications for HELZ2 Gene

  1. Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the DNA-binding domain of peroxisome proliferator-activated receptor gamma. (PMID: 16239304) Tomaru T. … Mori M. (Endocrinology 2006) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Identification of a transcriptionally active peroxisome proliferator- activated receptor alpha-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. (PMID: 12189208) Surapureddi S. … Reddy J.K. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4

Products for HELZ2 Gene

Sources for HELZ2 Gene

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