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HELZ2 Gene

protein-coding   GIFtS: 46
GCID: GC20M062190

Helicase With Zinc Finger 2, Transcriptional Coactivator

  Search for HELZ2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Helicase With Zinc Finger 2, Transcriptional Coactivator1 2 3     KIAA17693 5
PDIP12 3 5     PDIP-12
PRIC2852 3 5     Helicase With Zinc Finger Domain 22
Peroxisomal Proliferator Activated Receptor A Interacting Complex 2851 2     Peroxisomal Proliferator-Activated Receptor A Interacting Complex 2852
PPARG-DBD-Interacting Protein 11 2     Peroxisomal Proliferator-Activated Receptor Alpha-Interacting Cofactor
Complex, 285 KD Subunit2
Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 285 KDa
Protein2 3
     PPAR Gamma DBD-Interacting Protein 12
ATP-Dependent Helicase PRIC2852 3     PPARgamma-DNA-Binding Domain-Interacting Protein12
PPAR-Alpha-Interacting Complex Protein 2852 3     PRIC Complex2
PPAR-Gamma DBD-Interacting Protein 12 3     EC 3.6.4.-3
PPAR-Gamma DNA-Binding Domain-Interacting Protein 12 3     

External Ids:    HGNC: 300211   Entrez Gene: 854412   Ensembl: ENSG000001305897   OMIM: 6112655   UniProtKB: Q9BYK83   

Export aliases for HELZ2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HELZ2 Gene:
The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated
receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the
peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7
helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for HELZ2 Gene:
HELZ2 (helicase with zinc finger 2, transcriptional coactivator) is a protein-coding gene. GO annotations related to this gene include RNA binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is HELZ.

UniProtKB/Swiss-Prot: HELZ2_HUMAN, Q9BYK8
Function: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA,
PPARG, THRA, THRB and RXRA

Gene Wiki entry for HELZ2 (PRIC285) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HELZ2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHELZ2 promoter sequence
   Search Chromatin IP Primers for HELZ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HELZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

HELZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HELZ2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062190:  view genomic region     (about GC identifiers)

Start:
62,189,439 bp from pter      End:
62,205,592 bp from pter
Size:
16,154 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HELZ2_HUMAN, Q9BYK8 (See protein sequence)
Recommended Name: Helicase with zinc finger domain 2  
Size: 2649 amino acids; 294651 Da
Subunit: Interacts with PPARA (via DNA-binding domain) and PPARG; the interaction stimulates the transcriptional
activity of PPARA and PPARG. Interacts with THRAP3; the interaction is direct and HELZ2 and THRAP3
synergistically enhance the transcriptional activity of PPARG. It is probably part of the peroxisome proliferator
activated receptor alpha interacting complex (PRIC)
Caution: PubMed:12189208 experiments have been carried out partly in rat and partly in human
Sequence caution: Sequence=BAB70969.1; Type=Frameshift; Positions=2206;
Secondary accessions: Q3C2G2 Q4VXQ1 Q8TEF3 Q96ND3 Q9C094
Alternative splicing: 3 isoforms:  Q9BYK8-1   Q9BYK8-2   Q9BYK8-4   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HELZ2: NX_Q9BYK8

Explore proteomics data for HELZ2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HELZ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032412.2  NP_208384.3  

    ENSEMBL proteins: 
     ENSP00000393257   ENSP00000417401  
    Reactome Protein details: Q9BYK8

    HELZ2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR022966 RNase_II/R_CS
     IPR015880 Znf_C2H2-like
     IPR012340 NA-bd_OB-fold
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q9BYK8

    ProtoNet protein and cluster: Q9BYK8

    1 Blocks protein domain: IPB001900 Ribonuclease II

    UniProtKB/Swiss-Prot: HELZ2_HUMAN, Q9BYK8
    Domain: Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG
    Similarity: Belongs to the DNA2/NAM7 helicase family
    Similarity: Contains 1 C2H2-type zinc finger


    HELZ2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HELZ2_HUMAN, Q9BYK8
    Function: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA,
    PPARG, THRA, THRB and RXRA

         Enzyme Number (IUBMB): EC 3.6.4.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity ----
    GO:0004386helicase activity IEA--
    GO:0005515protein binding IPI16239304
    GO:0005524ATP binding IEA--
         
    HELZ2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HELZ2:
     Decreased Wnt reporter activit  Elongated cells with protrusio  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HELZ2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELZ2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HELZ2_HUMAN, Q9BYK8: Nucleus

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    HELZ2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HELZ2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Circadian Repression of Expression by REV-ERBA
    Circadian Repression of Expression by REV-ERBA0.88
    YAP1- and WWTR1 (TAZ)-stimulated gene expression0.40
    RORA Activates Circadian Expression0.88
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    Activation of Gene Expression by SREBP (SREBF)0.75
    4Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for HELZ2 (see all 10)
        Transcriptional regulation of white adipocyte differentiation
    Circadian Clock
    Transcriptional activation of mitochondrial biogenesis
    YAP1- and WWTR1 (TAZ)-stimulated gene expression
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)



    HELZ2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HELZ2
    Interactions:

        Search GeneGlobe Interaction Network for HELZ2

    3 Interacting proteins for HELZ2 (Q9BYK83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823I2D: score=2 
    PPARAQ078693I2D: score=1 
    PPARGP372313I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA16239304

    HELZ2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HELZ2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HELZ2 gene (2 alternative transcripts): 
    NM_001037335.2  NM_033405.3  

    Unigene Cluster for HELZ2:

    Helicase with zinc finger 2, transcriptional coactivator
    Hs.517180  [show with all ESTs]
    Unigene Representative Sequence: NM_001037335
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427522(uc002yfl.1) ENST00000478861 ENST00000467148(uc002yfm.2)
    ENST00000454223 ENST00000479540 ENST00000370082(uc002yfn.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HELZ2
      QuantiFast Probe-based Assays in human, mouse, rat HELZ2

    Additional mRNA sequence: 

    AB051556.2 AB201715.1 AB232667.1 AF517673.1 AK023724.1 AK055611.1 AK074171.1 BC036883.1 
    BC104974.1 BC112023.1 BC150283.1 

    7 DOTS entries:

    DT.102826711  DT.75168123  DT.102820312  DT.70102086  DT.120823388  DT.40218929  DT.97841213 

    Selected AceView cDNA sequences (see all 97):

    BQ441066 BX092705 AJ713391 BE279793 BU538654 AI613183 BQ053506 BF591176 
    NM_033405 AW732944 BU859751 AK074171 AI805682 BX479723 BQ962308 BV183876 
    BG773638 BX483447 BC036883 BF515946 BM809905 BQ707207 BQ053505 CF121929 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HELZ2 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21
    SP1:                                                              -                                                                                             
    SP2:                                                                                                                                -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -     -     -     -     -     -         
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for HELZ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HELZ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HELZ2 Expression
    About this image


    HELZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Liver (Hepatobiliary System)
    HELZ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HELZ2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517180

    UniProtKB/Swiss-Prot: HELZ2_HUMAN, Q9BYK8
    Tissue specificity: Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver,
    kidney, lung, peripheral blood and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HELZ2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Helz21 , 5 cDNA sequence BC0067795
    helicase with zinc finger 2, transcriptional coactivator1
    74.98(n)1
    70.7(a)1
      2 (103.63 cM)5
    2290031  NM_183162.21  NP_898985.21 
     1812276165 
    chicken
    (Gallus gallus)
    Aves HELZ21 helicase with zinc finger 2, transcriptional coactivator 59.67(n)
    51.33(a)
      419265  XM_004947281.1  XP_004947338.1 
    lizard
    (Anolis carolinensis)
    Reptilia HELZ26
    helicase with zinc finger 2, transcriptional coact...
    44(a)
    1 ↔ 1
    GL343401.1(582159-642154)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017336801 helicase with zinc finger domain 2-like 55.12(n)
    41.83(a)
      101733680  XM_004920597.1  XP_004920654.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5624611 helicase with zinc finger domain 2-like 48.63(n)
    41.89(a)
      562461  XM_003198847.2  XP_003198895.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAM76
    ATP-dependent RNA helicase of the SFI superfamily ...
    22(a)
    1 → many
    XIII(426712-429627) YMR080C


    ENSEMBL Gene Tree for HELZ2 (if available)
    TreeFam Gene Tree for HELZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HELZ2 gene
    HELZ2  MOV10L12  MOV102  UPF12  ZGRF12  
    2 SIMAP similar genes for HELZ2 using alignment to 1 protein entry:     HELZ2_HUMAN:
    PDIP1beta    PRIC285

    HELZ2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HELZ2 (see all 980)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61224761,2
    C,F,H--62189030(+) GGCTGG/ATGGCC 2 -- ds500118Minor allele frequency- A:0.39NS EA NA 2224
    rs61224771,2
    C,F,A,H--62189093(+) GTGGCC/TTGTCC 2 -- ds500121Minor allele frequency- T:0.43NS EA NA WA CSA 2156
    rs1503559451,2
    C--62189151(+) ACACCA/GGCCCT 2 -- ds50010--------
    rs1380762351,2
    --62189190(+) TCCTGC/TGCCCA 2 -- ds50010--------
    rs1836964521,2
    --62189300(+) CTCCAC/TGGCCG 2 -- ds50010--------
    rs1878007011,2
    C--62189336(+) CCCTGC/TGCCCA 2 -- ds50010--------
    rs1495451251,2
    --62189379(+) AACTGC/TGTACC 2 -- ds50010--------
    rs1442287421,2
    --62189441(+) AAGTGA/GGAAGA 2 -- ut310--------
    rs1911070241,2
    --62189459(+) GAGTGA/GTTTTA 2 -- ut310--------
    rs787787521,2
    C,F--62189604(+) ACATAC/AAGCCG 2 -- ut311Minor allele frequency- A:0.10WA 118

    HapMap Linkage Disequilibrium report for HELZ2 (62189439 - 62205592 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HELZ2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HELZ2
    DNA2.0 Custom Variant and Variant Library Synthesis for HELZ2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611265    OMIM disorders: --


    HELZ2 for disorders           About GeneDecksing


    Export disorders for HELZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HELZ2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with HELZ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the DNA-binding domain of peroxisome proliferator-activated receptor gamma. (PubMed id 16239304)1, 2, 3, 9 Tomaru T.... Mori M. (Endocrinology 2006)
    2. Identification of a transcriptionally active peroxisome proliferator- activated receptor alpha-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. (PubMed id 12189208)1, 2, 3 Surapureddi S....Reddy J.K. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    4. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. (PubMed id 23525231)1, 2 Katano-Toki A.... Mori M. (Mol. Endocrinol. 2013)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. (PubMed id 22446964)1 Fairfax B.P....Knight J.C. (Nat. Genet. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85441 HGNC: 30021 AceView: PRIC285 Ensembl:ENSG00000130589 euGenes: HUgn85441
    ECgene: HELZ2 H-InvDB: HELZ2

    (According to HUGE)
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    HUGE: KIAA1769

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HELZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HELZ2 gene:
    Search GeneIP for patents involving HELZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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