Aliases for HELZ Gene
Aliases for HELZ Gene
External Ids for HELZ Gene
- HGNC: 16878
- Entrez Gene: 9931
- Ensembl: ENSG00000198265
- OMIM: 606699
- UniProtKB: P42694
Previous GeneCards Identifiers for HELZ Gene
- GC17P063140
- GC17P066240
- GC17M065491
- GC17M065624
- GC17M062504
- GC17M065066
- GC17M060455
Summaries for HELZ Gene
-
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]
GeneCards Summary for HELZ Gene
HELZ (Helicase With Zinc Finger) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and helicase activity. An important paralog of this gene is HELZ2.
UniProtKB/Swiss-Prot for HELZ Gene
-
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELZ Gene
Genomics for HELZ Gene
Regulatory Elements for HELZ Gene
Regulatory Element Products
Genomic Location for HELZ Gene
- Chromosome:
- 17
- Start:
- 67,070,438 bp from pter
- End:
- 67,245,989 bp from pter
- Size:
- 175,552 bases
- Orientation:
- Minus strand
Genomic View for HELZ Gene
- Cytogenetic band:
-
- 17q24.2 by Ensembl
- 17q24.2 by Entrez Gene
- 17q24.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HELZ Gene
Proteins for HELZ Gene
-
Protein details for HELZ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P42694-HELZ_HUMAN
- Recommended name:
- Probable helicase with zinc finger domain
- Protein Accession:
- P42694
- I6L9H4
Protein attributes for HELZ Gene
- Size:
- 1942 amino acids
- Molecular mass:
- 218970 Da
- Quaternary structure:
-
- Interacts with SMYD2 (By similarity). Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II.
- SequenceCaution:
-
- Sequence=BAA06147.3; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for HELZ Gene
Post-translational modifications for HELZ Gene
Other Protein References for HELZ Gene
Antibody Products
- Novus Biologicals Antibodies for HELZ
- Invitrogen Antibodies for HELZ
- antibodies-online Antibodies for HELZ: See all 20
- GeneTex Lif antibody for HELZ
-
Santa Cruz Biotechnology (SCBT) Antibodies for HELZ
Protein Products
-
OriGene Purified Proteins for HELZ
- Search Origene for MassSpec and Protein Over-expression Lysates for HELZ
- Origene Custom Protein Services for HELZ
- Search GeneTex for Proteins for HELZ
-
ProSci Proteins for HELZ
Assay Products
- antibodies-online Kits for HELZ: See all 2
No data available for DME Specific Peptides for HELZ Gene
Domains & Families for HELZ Gene
Gene Families for HELZ Gene
Protein Domains for HELZ Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HELZ Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P42694- Family:
-
- Belongs to the DNA2/NAM7 helicase family.
Function for HELZ Gene
Molecular function for HELZ Gene
- UniProtKB/Swiss-Prot Function:
- May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
Enzyme Numbers (IUBMB) for HELZ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for HELZ Gene
- MGI mutant phenotypes for HELZ:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HELZ:
-
- Increased vaccinia virus (VACV) infection
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased POU5F1-GFP protein expression
- Decreased IL-8 secretion
- Increased Nanog expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HELZ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HELZ gene
- Search ViGene Biosciences for HELZ
CRISPR Products
-
OriGene CRISPR knockouts for HELZ
-
Santa Cruz Biotechnology (SCBT) CRISPR for HELZ
- GenScript: Design CRISPR guide RNA sequences for HELZ
miRNA for HELZ Gene
- miRTarBase miRNAs that target HELZ
miRNA Products
- Search ViGene Biosciences for HELZ
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HELZ
- Browse OriGene Inhibitory RNA Products For HELZ
-
ViGene Biosciences ready-to-package AAV shRNAs for HELZ gene
Cell Line Products
-
Horizon Cell Lines for HELZ
-
ViGene Biosciences adenoviral particle packaged cDNA for HELZ gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HELZ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HELZ gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HELZ Gene
Localization for HELZ Gene
Subcellular locations from UniProtKB/Swiss-Prot for HELZ Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0016020 | membrane | IEA,IDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for HELZ Gene
No data available for Pathways by source and SIGNOR curated interactions for HELZ Gene
Transcripts for HELZ Gene
mRNA/cDNA for HELZ Gene
- (10) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (258) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HELZ Gene
CRISPR Products
-
OriGene CRISPR knockouts for HELZ
-
Santa Cruz Biotechnology (SCBT) CRISPR for HELZ
- GenScript: Design CRISPR guide RNA sequences for HELZ
miRNA Products
- Search ViGene Biosciences for HELZ
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HELZ
- Browse OriGene Inhibitory RNA Products For HELZ
-
ViGene Biosciences ready-to-package AAV shRNAs for HELZ gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: |
Expression for HELZ Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HELZ Gene
NURSA nuclear receptor signaling pathways regulating expression of HELZ Gene:
HELZSOURCE GeneReport for Unigene cluster for HELZ Gene:
Hs.370140mRNA Expression by UniProt/SwissProt for HELZ Gene:
P42694-HELZ_HUMANEvidence on tissue expression from TISSUES for HELZ Gene
- Liver(4.4)
- Bone marrow(4.3)
- Nervous system(2.2)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for HELZ
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HELZ Gene
Orthologs for HELZ Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HELZ 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HELZ 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HELZ 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Helz 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Helz 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HELZ 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HELZ 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| LOC100857488 34 |
|
||||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | HELZ 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | helz 34 |
|
||
| Str.15539 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9984 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | helz 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5746 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9425 36 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NAM7 35 |
|
OneToMany |
- Species where no ortholog for HELZ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HELZ Gene
Variants for HELZ Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011650 | -- | 67,155,639(+) | CGAGG(C/T)CAGCC | intron-variant | |
| rs1000020750 | -- | 67,077,820(+) | TTGTA(C/T)ATCAA | nc-transcript-variant, utr-variant-3-prime | |
| rs1000030591 | -- | 67,077,531(+) | CAAGC(C/T)TGAAG | nc-transcript-variant, utr-variant-3-prime | |
| rs1000054868 | -- | 67,201,508(+) | GGAAA(A/G)CAACC | intron-variant | |
| rs1000081050 | -- | 67,103,261(+) | AATCA(A/T)GAATT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3276n100 | CNV | loss | 25217958 |
| esv2558362 | CNV | insertion | 19546169 |
| nsv1059962 | CNV | loss | 25217958 |
| nsv1067245 | CNV | loss | 25217958 |
| nsv1120054 | OTHER | inversion | 24896259 |
| nsv1125640 | CNV | tandem duplication | 24896259 |
| nsv469731 | CNV | loss | 16826518 |
| nsv960525 | CNV | duplication | 23825009 |
Relevant External Links for HELZ Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELZ Gene
Disorders for HELZ Gene
Relevant External Links for HELZ
No disorders were found for HELZ Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HELZ Gene
Publications for HELZ Gene
- Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. (PMID: 12691822) Nagai H. … Emi M. (Cancer Lett. 2003) 2 3 4 64
- Identification of a differentially expressed RNA helicase by gene trapping. (PMID: 10471385) Wagner D.S. … Klein W.H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 64
- Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. (PMID: 20378664) Sombekke M.H. … Uitdehaag B.M. (Mult. Scler. 2010) 3 46 64
- SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. (PMID: 15235609) Hamamoto R. … Nakamura Y. (Nat. Cell Biol. 2004) 3 4 64
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4 64
Products for HELZ Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HELZ
- Search Origene for MassSpec and Protein Over-expression Lysates for HELZ
- Origene Custom Protein Services for HELZ
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HELZ
- Browse OriGene Inhibitory RNA Products For HELZ
- OriGene qPCR primer pairs for HELZ
- OriGene CRISPR knockouts for HELZ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HELZ
- GenScript: Next-day shipping cDNA ORF clone for HELZ in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HELZ
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- GenScript Custom overexpressing Cell Line Services for HELZ
- GenScript: Design CRISPR guide RNA sequences for HELZ
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HELZ
- Novus Biologicals proteins and lysates for HELZ
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HELZ: See all 20
- antibodies-online Kits for HELZ: See all 2
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex Lif antibody for HELZ
- Search GeneTex for Proteins for HELZ
- ViGene Biosciences adenoviral particle packaged cDNA for HELZ gene
- ViGene Biosciences lentiviral particle packaged cDNA for HELZ gene
- ViGene Biosciences ready-to-package AAV shRNAs for HELZ gene
- Search ViGene Biosciences for HELZ
- Santa Cruz Biotechnology (SCBT) Antibodies for HELZ
- Search Santa Cruz Biotechnology (SCBT) for HELZ siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HELZ
- Search for HELZ Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for HELZ
- Horizon Cell Lines for HELZ
- Cyagen custom Knockout/knockin (KOKI) mouse models for HELZ
- VectorBuilder custom plasmid, inducible vectors for HELZ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HELZ
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HELZ Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




