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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HELZ Gene

protein-coding GIFtS: 52
GCID: GC17M065066

helicase with zinc finger

Explore 3 diseases affiliated with
HELZ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Helicase With Zinc Finger¹ ²		DRHC² ³
HUMORF5¹ ² ⁵		Helicase With Zinc Finger Domain²
KIAA0054¹ ³ ⁵		Probable Helicase With Zinc Finger Domain²
DHRC¹ ²		EC 3.6.4.-³
Down-Regulated In Human Cancers Protein² ³

External Ids:	HGNC: 16878¹	Entrez Gene: 9931²	Ensembl: ENSG00000198265⁷	OMIM: 606699⁵	UniProtKB: P42694³

Export aliases for HELZ gene to outside databases

Previous GC identifers: GC17P063140 GC17P066240 GC17M065491 GC17M065624 GC17M062504 GC17M060455

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HELZ:

HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding

double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other

proteins (Wagner et al., 1999 (PubMed 10471385)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694

Function: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the

developing embryo

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HELZ gene promoter:
FOXF2 p300 AP-4 NF-E2 p45 Meis-1b MEF-2A aMEF-2 Meis-1a NF-E2 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HELZ promoter sequence

Search SABiosciences Chromatin IP Primers for HELZ

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HELZ

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2 Ensembl cytogenetic band: 17q24.2 HGNC cytogenetic band: 17q24.2

HELZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HELZ gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M065066: view genomic region (about GC identifiers)

Start:	65,066,554 bp from pter	End:	65,242,105 bp from pter
Size:	175,552 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694 (See protein sequence)

Recommended Name: Probable helicase with zinc finger domain

Size: 1942 amino acids; 218970 Da

Subunit: Interacts with SMYD2 (By similarity). Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge

SMYD3 and RNA polymerase II

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAA06147.3; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for HELZ: NX_P42694

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P42694

HELZ Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055692.2

ENSEMBL proteins:

ENSP00000351524 ENSP00000463727 ENSP00000464512 ENSP00000411144 ENSP00000464354

ENSP00000462763 ENSP00000462320

Human Recombinant Protein Products:

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	Novus Biologicals HELZ Protein Novus Biologicals HELZ Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HELZ

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

HELZ for ontologies About GeneDecksing

HELZ Antibody Products:

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	Search ThermoFisher Antibodies for HELZ

Assay Products for HELZ:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HELZ

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HELZ for domains About GeneDecksing

1 InterPro domain/family:

IPR000571 Znf_CCCH

Graphical View of Domain Structure for InterPro Entry P42694

ProtoNet protein and cluster: P42694

2 Blocks protein families:

IPB000571 Zn-finger

IPB009818 Ataxin-2

UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694

Similarity: Belongs to the DNA2/NAM7 helicase family

Similarity: Contains 1 C3H1-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694

Function: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the

developing embryo

Enzyme Number (IUBMB): EC 3.6.4.-¹

miRNA Products:		OriGene 3'-UTR Clone: HELZ Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HELZ
		8/159 QIAGEN miScript miRNA Assays for microRNAs that regulate HELZ (see all 159):
		hsa-miR-411* hsa-miR-100* hsa-miR-193a-3p hsa-miR-759 hsa-miR-1243 hsa-miR-3170 hsa-miR-4326 hsa-miR-374b*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HELZ (see all 7) OriGene shRNA RFP: HELZ OriGene siRNA: HELZ
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HELZ

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HELZ

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HELZ (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HELZ OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HELZ (NM_014877)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HELZ
		Search LifeMap BioReagents cell lines for HELZ

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELZ

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0004386	helicase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

HELZ for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for HELZ:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Helz):

normal

HELZ for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HELZ

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/11 Interacting proteins for HELZ (P42694³ ENSP00000351524⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3YL1	Q96HL8³, ENSP00000404143⁴	I2D: score=1 STRING: ENSP00000404143
SMYD3	Q9H7B4³, ENSP00000373637⁴	I2D: score=1 STRING: ENSP00000373637
SUMO3	P55854³, ENSP00000330343⁴	I2D: score=1 STRING: ENSP00000330343
GRB2	P62993³, ENSP00000339007⁴	I2D: score=1 STRING: ENSP00000339007
SMYD2	Q9NRG4³, ENSP00000355924⁴	I2D: score=1 STRING: ENSP00000355924

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HELZ
Search CenterWatch for drugs/clinical trials and news about HELZ

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HELZ gene:

NM_014877.3

Unigene Cluster for HELZ:

Helicase with zinc finger

Hs.370140 [show with all ESTs]

Unigene Representative Sequence: NM_014877

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000358691(uc002jfv.4 uc002jfx.4 uc010wqk.2) ENST00000579953

ENST00000580168(uc010der.3) ENST00000417253 ENST00000578783 ENST00000578938

ENST00000582864 ENST00000580662 ENST00000584641(uc010des.1) ENST00000581159

ENST00000580963 ENST00000579861

miRNA Products:		OriGene 3'-UTR Clone: HELZ Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HELZ
		8/159 QIAGEN miScript miRNA Assays for microRNAs that regulate HELZ (see all 159):
		hsa-miR-411* hsa-miR-100* hsa-miR-193a-3p hsa-miR-759 hsa-miR-1243 hsa-miR-3170 hsa-miR-4326 hsa-miR-374b*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HELZ (see all 7) OriGene shRNA RFP: HELZ OriGene siRNA: HELZ
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HELZ

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HELZ (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HELZ OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HELZ (NM_014877)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HELZ
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELZ

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HELZ Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HELZ
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HELZ

Additional cDNA sequence:

AK310217.1 AK310639.1 AL110161.1 AL832149.1 BC056895.1 BC130582.1 BC144083.1 D29677.2

7 DOTS entries:

DT.414677 DT.95174819 DT.91751297 DT.86838915 DT.91751298 DT.95212275 DT.97786159

24/258 AceView cDNA sequences (see all 258):

CD653403 AI271466 CA841076 AW073412 AW518884 AL698926 D29677 AA226729

BU153194 BM680759 H82539 AI916086 BM701802 BP375915 BM973722 AW074030

BE220753 BU170969 AI824339 H69058 BE672173 AW572123 BF036468 BM671964

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HELZ (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:																															-
SP2:																															-
SP3:
SP4:																			-		-
SP5:			-

ExUns:	24	^	25	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35a	·	35b
SP1:							-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for HELZ

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HELZ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAACAAAAT

About this image

HELZ expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung Bud

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HELZ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HELZ

SOURCE GeneReport for Unigene cluster: Hs.370140

UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694

Tissue specificity: Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested cancer

cell lines

SABiosciences Custom PCR Arrays for HELZ

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HELZ

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELZ

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HELZ gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HELZ¹	helicase with zinc finger	83.34(n) 86.01(a)		417427 XM_415679.3 XP_415679.2
lizard (Anolis carolinensis)	Reptilia	HELZ⁶	--	83(a)	1 ↔ 1	GL343250.1(434819-544210)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9984²	Xenopus laevis transcribed sequence with weak similarity more	75.27(n)		BJ625391.1
zebrafish (Danio rerio)	Actinopterygii	AL914540.1²	--	78.86(n)		AL914540.1
fruit fly (Drosophila melanogaster)	Insecta	CG9425³	--	49(a)		70F6 --

ENSEMBL Gene Tree for HELZ (if available)
TreeFam Gene Tree for HELZ (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HELZ gene

HELZ2² MOV10L1² IGHMBP2² MOV10²

HELZ for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35055892^1,2	C	--	60552391(+)	`AAAAA-/TTTTTT`	1	--	int¹		2		NA	4
rs182136079^1,2		--	65066058(+)	`CACAAC/TCAGCA`	1	--	ds500¹		0	--	--	--	--
rs6504486^1,2	C,F,H,	--	65066096(+)	`TAATGC/TTTGGC`	1	--	ds500¹		27		NA NS EA WA CSA	2488
rs141762192^1,2		--	65066103(+)	`TGGCAC/TGCATT`	1	--	ds500¹		0	--	--	--	--
rs186799311^1,2		--	65066139(+)	`CATAAC/TATATC`	1	--	ds500¹		0	--	--	--	--
rs191648378^1,2		--	65066323(+)	`TAACAC/TGTTTA`	1	--	ds500¹		0	--	--	--	--
rs150417115^1,2		--	65066384(+)	`ATGTCC/TGGAAA`	1	--	ds500¹		0	--	--	--	--
rs138227081^1,2		--	65066532(+)	`TTATAA/GTTCAC`	1	--	ds500¹		0	--	--	--	--
rs149597037^1,2		--	65066663(+)	`CAATGA/CGCACA`	1	--	ut3¹		0	--	--	--	--
rs144220955^1,2		--	65066697(+)	`TTGAAA/CACTTG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HELZ (65066554 - 65242105 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HELZ
1 CNV: 2232
1 Indel: 102511

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HELZ

DNA2.0 Custom Variant and Variant Library Synthesis for HELZ

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HELZ for disorders           About GeneDecksing

OMIM gene information: 606699    OMIM disorders: --

3 diseases for HELZ:    About MalaCards

nonepidermolytic palmoplantar keratoderma keratoderma multiple sclerosis

1 disease from the University of Copenhagen DISEASES database for HELZ:

Nonepidermolytic palmoplantar keratoderma

Human Genome Epidemiology (HuGE) Navigator: HELZ (1 document)

Export disorders for HELZ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HELZ gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with HELZ)

Utopia: connect your pdf to the dynamic
world of online information

Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. (PubMed id 12691822)^{1, 2, 3} Nagai H.... Emi M. (2003)
Identification of a differentially expressed RNA helicase by gene trapping. (PubMed id 10471385)^{1, 2, 3} Wagner D.S.... Klein W.H. (1999)
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. (PubMed id 15235609)^{1, 2} Hamamoto R.... Nakamura Y. (2004)
Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)^{1, 2} Nomura N....Tabata S. (1994)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
The putative RNA helicase HELZ promotes cell prolifer ation, translation initiation and ribosomal protein S6 phosphorylation. (PubMed id 21765940)¹ Hasgall P.A....Camenisch G. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9931	HGNC: 16878	AceView: HELZ	Ensembl:ENSG00000198265	euGenes: HUgn9931
ECgene: HELZ	H-InvDB: HELZ

(According to HUGE)
About This Section

HUGE: KIAA0054

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HELZ	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HELZ gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HELZ gene:
Search GeneIP for patents involving HELZ

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for HELZ
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HELZ		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HELZ
	OriGene Protein Over-expression Lysate for HELZ		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HELZ		OriGene 3'-UTR Clone for HELZ
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	OriGene Custom Antibody Services for HELZ		OriGene Custom Protein Services for HELZ
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HELZ
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HELZ
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HELZ
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HELZ
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	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HELZ

	GenScript Custom Purified and Recombinant Proteins Services for HELZ		GenScript cDNA clones with any tag delivered in your preferred vector for HELZ
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Search for Antibodies & Assays

	Regulatory tfbs in HELZ promoter
	Search Chromatin IP Primers for HELZ
	RT² qPCR Primer Assay in human, mouse, rat HELZ
	Search GNC Networks for HELZ
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Search Tocris compounds for HELZ

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	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HELZ antibodies
	HELZ proteins
	HELZ lysates

	Search for Antibodies for HELZ at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HELZ
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HELZ Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HELZ

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELZ

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HELZ
	SwitchGear Promoter luciferase reporter plasmids for HELZ

Search ThermoFisher Antibodies for HELZ

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELZ

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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HELZ Gene

helicase with zinc finger

Aliases
for HELZ gene

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Proteins
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HELZ Gene

helicase with zinc finger

Aliasesfor HELZ gene

Summariesfor HELZ gene

Genomic Viewsfor HELZ gene

Proteinsfor HELZ gene

Protein Domains /Familiesfor HELZ gene

Functionfor HELZ gene

Pathways & Interactionsfor HELZ gene

Drugs & Compoundsfor HELZ gene

Transcriptsfor HELZ gene

Expression for HELZ gene

Orthologsfor HELZ gene

Paralogsfor HELZ gene

Genomic Variantsfor HELZ gene

Disorders / Diseasesfor HELZ gene

Publicationsfor HELZ gene

External Searches for HELZ gene

Genome Databases showing HELZ gene

Other Databases showing HELZ gene

Specialized Databases showing HELZ gene

Intellectual Propertyfor HELZ gene

Productsfor HELZ gene

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Aliases
for HELZ gene

Summaries
for HELZ gene

Genomic Views
for HELZ gene

Proteins
for HELZ gene

Protein Domains /
Families
for HELZ gene

Function
for HELZ gene

Pathways & Interactions
for HELZ gene

Drugs & Compounds
for HELZ gene

Transcripts
for HELZ gene

Expression
for HELZ gene

Orthologs
for HELZ gene

Paralogs
for HELZ gene

Genomic Variants
for HELZ gene

Disorders / Diseases
for HELZ gene

Publications
for HELZ gene

Intellectual Property
for HELZ gene

Products
for HELZ gene