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Aliases for HELZ Gene

Aliases for HELZ Gene

  • Helicase With Zinc Finger 2 3 5
  • Down-Regulated In Human Cancers Protein 3 4
  • DRHC 3 4
  • Helicase With Zinc Finger Domain 3
  • Down-Regulated In Human Cancers 2
  • EC 3.6.4.- 4
  • KIAA0054 4
  • HUMORF5 3
  • DHRC 3

External Ids for HELZ Gene

Previous GeneCards Identifiers for HELZ Gene

  • GC17P063140
  • GC17P066240
  • GC17M065491
  • GC17M065624
  • GC17M062504
  • GC17M065066
  • GC17M060455

Summaries for HELZ Gene

Entrez Gene Summary for HELZ Gene

  • HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HELZ Gene

HELZ (Helicase With Zinc Finger) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and helicase activity. An important paralog of this gene is UPF1.

UniProtKB/Swiss-Prot for HELZ Gene

  • May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELZ Gene

Genomics for HELZ Gene

Regulatory Elements for HELZ Gene

Promoters for HELZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HELZ on UCSC Golden Path with GeneCards custom track

Genomic Location for HELZ Gene

Chromosome:
17
Start:
67,070,438 bp from pter
End:
67,245,989 bp from pter
Size:
175,552 bases
Orientation:
Minus strand

Genomic View for HELZ Gene

Genes around HELZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HELZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HELZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELZ Gene

Proteins for HELZ Gene

  • Protein details for HELZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42694-HELZ_HUMAN
    Recommended name:
    Probable helicase with zinc finger domain
    Protein Accession:
    P42694
    Secondary Accessions:
    • I6L9H4

    Protein attributes for HELZ Gene

    Size:
    1942 amino acids
    Molecular mass:
    218970 Da
    Quaternary structure:
    • Interacts with SMYD2 (By similarity). Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II.
    SequenceCaution:
    • Sequence=BAA06147.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HELZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HELZ Gene

Proteomics data for HELZ Gene at MOPED

Post-translational modifications for HELZ Gene

  • Ubiquitination at Lys 56
  • Modification sites at PhosphoSitePlus

Other Protein References for HELZ Gene

No data available for DME Specific Peptides for HELZ Gene

Domains & Families for HELZ Gene

Protein Domains for HELZ Gene

Suggested Antigen Peptide Sequences for HELZ Gene

Graphical View of Domain Structure for InterPro Entry

P42694

UniProtKB/Swiss-Prot:

HELZ_HUMAN :
  • Belongs to the DNA2/NAM7 helicase family.
  • Contains 1 C3H1-type zinc finger.
Family:
  • Belongs to the DNA2/NAM7 helicase family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with HELZ: view

Function for HELZ Gene

Molecular function for HELZ Gene

UniProtKB/Swiss-Prot Function:
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.

Enzyme Numbers (IUBMB) for HELZ Gene

Gene Ontology (GO) - Molecular Function for HELZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HELZ: view
genes like me logo Genes that share phenotypes with HELZ: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HELZ Gene

Localization for HELZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HELZ Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HELZ Gene COMPARTMENTS Subcellular localization image for HELZ gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HELZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HELZ: view

Pathways & Interactions for HELZ Gene

SuperPathways for HELZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HELZ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HELZ Gene

Drugs & Compounds for HELZ Gene

No Compound Related Data Available

Transcripts for HELZ Gene

Unigene Clusters for HELZ Gene

Helicase with zinc finger:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HELZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2: -
SP3:
SP4: - -
SP5: -
SP6:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for HELZ Gene

GeneLoc Exon Structure for
HELZ
ECgene alternative splicing isoforms for
HELZ

Expression for HELZ Gene

mRNA expression in normal human tissues for HELZ Gene

Protein differential expression in normal tissues from HIPED for HELZ Gene

This gene is overexpressed in Breast (18.1), Testis (17.3), Peripheral blood mononuclear cells (11.8), and Plasma (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HELZ Gene



SOURCE GeneReport for Unigene cluster for HELZ Gene Hs.370140

mRNA Expression by UniProt/SwissProt for HELZ Gene

P42694-HELZ_HUMAN
Tissue specificity: Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested cancer cell lines.
genes like me logo Genes that share expression patterns with HELZ: view

Protein tissue co-expression partners for HELZ Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HELZ Gene

Orthologs for HELZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HELZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HELZ 35
  • 89.47 (n)
  • 92.36 (a)
HELZ 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HELZ 35
  • 94.22 (n)
  • 95.93 (a)
HELZ 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Helz 35
  • 87.83 (n)
  • 91.71 (a)
Helz 16
Helz 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HELZ 35
  • 99.67 (n)
  • 99.69 (a)
HELZ 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Helz 35
  • 87.97 (n)
  • 91.71 (a)
oppossum
(Monodelphis domestica)
Mammalia HELZ 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HELZ 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves HELZ 35
  • 82.91 (n)
  • 85.49 (a)
-- 36
  • 86 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HELZ 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia helz 35
  • 71.86 (n)
  • 76.73 (a)
Str.15539 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9984 35
zebrafish
(Danio rerio)
Actinopterygii helz 35
  • 66.84 (n)
  • 73.2 (a)
helz 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5746 35
fruit fly
(Drosophila melanogaster)
Insecta CG9425 37
  • 49 (a)
CG9425 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 36
  • 16 (a)
OneToMany
Species with no ortholog for HELZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HELZ Gene

ENSEMBL:
Gene Tree for HELZ (if available)
TreeFam:
Gene Tree for HELZ (if available)

Paralogs for HELZ Gene

Paralogs for HELZ Gene

genes like me logo Genes that share paralogs with HELZ: view

Variants for HELZ Gene

Sequence variations from dbSNP and Humsavar for HELZ Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2302669 - 67,218,663(+) TGGAC(A/G)AGGCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs8080100 - 67,215,926(+) TTGCA(C/T)ATAAT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs11653020 - 67,108,627(+) ATGGA(A/G)CGCTG reference, missense
rs11193 -- 67,070,763(-) GTAAA(C/T)GATAC utr-variant-3-prime
rs720059 -- 67,086,001(+) GATTC(C/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HELZ Gene

Variant ID Type Subtype PubMed ID
nsv469731 CNV Loss 16826518
nsv908690 CNV Loss 21882294
esv2558362 CNV Insertion 19546169

Variation tolerance for HELZ Gene

Residual Variation Intolerance Score: 4.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.24; 90.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HELZ Gene

HapMap Linkage Disequilibrium report
HELZ
Human Gene Mutation Database (HGMD)
HELZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELZ Gene

Disorders for HELZ Gene

Relevant External Links for HELZ

Genetic Association Database (GAD)
HELZ
Human Genome Epidemiology (HuGE) Navigator
HELZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HELZ

No disorders were found for HELZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HELZ Gene

Publications for HELZ Gene

  1. Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. (PMID: 12691822) Nagai H. … Emi M. (Cancer Lett. 2003) 2 3 4 67
  2. Identification of a differentially expressed RNA helicase by gene trapping. (PMID: 10471385) Wagner D.S. … Klein W.H. (Biochem. Biophys. Res. Commun. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for HELZ Gene

Sources for HELZ Gene

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