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HELZ Gene

protein-coding   GIFtS: 54
GCID: GC17M065066

Helicase With Zinc Finger

  See HELZ-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Helicase With Zinc Finger1 2     Down-Regulated In Human Cancers1
Down-Regulated In Human Cancers Protein2 3     DHRC2
DRHC2 3     Helicase With Zinc Finger Domain2
HUMORF52 5     Probable Helicase With Zinc Finger Domain2
KIAA00543 5     EC 3.6.4.-3

External Ids:    HGNC: 168781   Entrez Gene: 99312   Ensembl: ENSG000001982657   OMIM: 6066995   UniProtKB: P426943   

Export aliases for HELZ gene to outside databases

Previous GC identifers: GC17P063140 GC17P066240 GC17M065491 GC17M065624 GC17M062504 GC17M060455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HELZ Gene:
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by
unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating
access to other proteins (Wagner et al., 1999 (PubMed 10471385)).(supplied by OMIM, Mar 2008)

GeneCards Summary for HELZ Gene:
HELZ (helicase with zinc finger) is a protein-coding gene. Diseases associated with HELZ include nonepidermolytic palmoplantar keratoderma. GO annotations related to this gene include helicase activity. An important paralog of this gene is HELZ2.

UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694
Function: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the
developing embryo




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HELZ gene promoter:
         FOXF2   p300   AP-4   NF-E2 p45   Meis-1b   MEF-2A   aMEF-2   Meis-1a   NF-E2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHELZ promoter sequence
   Search Chromatin IP Primers for HELZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HELZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24.2

HELZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HELZ gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M065066:  view genomic region     (about GC identifiers)

Start:
65,066,554 bp from pter      End:
65,242,105 bp from pter
Size:
175,552 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694 (See protein sequence)
Recommended Name: Probable helicase with zinc finger domain  
Size: 1942 amino acids; 218970 Da
Subunit: Interacts with SMYD2 (By similarity). Interacts with POLR2A. Interacts with SMYD3; the interaction may
bridge SMYD3 and RNA polymerase II
Sequence caution: Sequence=BAA06147.3; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for HELZ: NX_P42694

Explore proteomics data for HELZ at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys56
  • Modification sites at PhosphoSitePlus

  • See HELZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055692.2  
    ENSEMBL proteins: 
     ENSP00000351524   ENSP00000463727   ENSP00000464512   ENSP00000411144   ENSP00000464354  
     ENSP00000462763   ENSP00000462320  

    HELZ Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HELZ
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HELZ
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    Novus Biologicals HELZ Protein
    Novus Biologicals HELZ Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HELZ

     
    Search eBioscience for Proteins for HELZ 

    HELZ Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for HELZ

    HELZ Assay Products:

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    Cloud-Clone Corp. CLIAs for HELZ
    Search eBioscience for ELISAs for HELZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing

    2 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P42694

    ProtoNet protein and cluster: P42694

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB009818 Ataxin-2


    UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694
    Similarity: Belongs to the DNA2/NAM7 helicase family
    Similarity: Contains 1 C3H1-type zinc finger


    Find genes that share domains with HELZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HELZ_HUMAN, P42694
    Function: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the
    developing embryo

         Enzyme Number (IUBMB): EC 3.6.4.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004386helicase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with HELZ           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HELZ:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Helz):
     normal 

    Find genes that share phenotypes with HELZ           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HELZ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HELZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HELZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HELZ

    miRNA
    Products:
        
    miRTarBase miRNAs that target HELZ:
    hsa-mir-16-5p (MIRT031728), hsa-mir-103a-3p (MIRT027127), hsa-mir-130b-5p (MIRT038308), hsa-mir-186-5p (MIRT045007)

    Block miRNA regulation of human, mouse, rat HELZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HELZ (see all 159):
    hsa-miR-411* hsa-miR-100* hsa-miR-193a-3p hsa-miR-759 hsa-miR-1243 hsa-miR-3170 hsa-miR-4326 hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat HELZ

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for HELZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HELZ (NM_014877)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HELZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELZ

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HELZ
    Browse ESI BIO Cell Lines and PureStem Progenitors for HELZ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HELZ_HUMAN, P42694: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with HELZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HELZ
    Interactions:

        Search GeneGlobe Interaction Network for HELZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for HELZ (P426943 ENSP000003515244) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3YL1Q96HL83, ENSP000004041434I2D: score=1 STRING: ENSP00000404143
    SMYD3Q9H7B43, ENSP000003736374I2D: score=1 STRING: ENSP00000373637
    SUMO3P558543, ENSP000003303434I2D: score=1 STRING: ENSP00000330343
    SMYD2Q9NRG43, ENSP000003559244I2D: score=1 STRING: ENSP00000355924
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HELZ



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HELZ gene: 
    NM_014877.3  

    Unigene Cluster for HELZ:

    Helicase with zinc finger
    Hs.370140  [show with all ESTs]
    Unigene Representative Sequence: NM_014877
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358691(uc002jfv.4 uc002jfx.4 uc010wqk.2) ENST00000579953
    ENST00000580168(uc010der.3) ENST00000417253 ENST00000578783 ENST00000578938
    ENST00000582864 ENST00000580662 ENST00000584641(uc010des.1) ENST00000581159
    ENST00000580963 ENST00000579861
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HELZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HELZ (see all 159):
    hsa-miR-411* hsa-miR-100* hsa-miR-193a-3p hsa-miR-759 hsa-miR-1243 hsa-miR-3170 hsa-miR-4326 hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HELZ
    Predesigned siRNA for gene silencing in human, mouse, rat HELZ
    Clone
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    OriGene clones in human, mouse for HELZ (see all 5)
    OriGene ORF clones in mouse, rat for HELZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HELZ (NM_014877)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HELZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELZ
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HELZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HELZ
      QuantiTect SYBR Green Assays in human, mouse, rat HELZ
      QuantiFast Probe-based Assays in human, mouse, rat HELZ

    Additional mRNA sequence: 

    AK310217.1 AK310639.1 AL110161.1 AL832149.1 BC056895.1 BC130582.1 BC144083.1 D29677.2 

    7 DOTS entries:

    DT.414677  DT.95174819  DT.91751297  DT.86838915  DT.91751298  DT.95212275  DT.97786159 

    Selected AceView cDNA sequences (see all 258):

    AI304519 AA307701 AW074030 BG622798 AA226729 BM542539 BM671964 BE550497 
    AA227469 AL698926 AA371268 AL712830 AA714646 BM973722 H47874 BP375915 
    BQ884277 AI253135 BM683132 BM720199 BE672173 BM701802 D29677 CA841076 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HELZ (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                            -                                                               
    SP2:                                                                                            -                                                               
    SP3:                                                                                                                                                            
    SP4:                                                        -     -                                                                                             
    SP5:        -                                                                                                                                                   

    ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
    SP1:                    -                                                               
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for HELZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HELZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAACAAAAT
    HELZ Expression
    About this image

    HELZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HELZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370140

    UniProtKB/Swiss-Prot: HELZ_HUMAN, P42694
    Tissue specificity: Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested
    cancer cell lines

        Custom PCR Arrays for HELZ
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HELZ
    QuantiTect SYBR Green Assays in human, mouse, rat HELZ
    QuantiFast Probe-based Assays in human, mouse, rat HELZ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HELZ gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Helz1 , 5 helicase with zinc finger domain1, 5 87.83(n)1
    91.71(a)1
      11 (70.29 cM)5
    784551  NM_198298.11  NP_938040.11 
     1075479305 
    chicken
    (Gallus gallus)
    Aves HELZ1 helicase with zinc finger 82.91(n)
    85.49(a)
      417427  XM_415679.4  XP_415679.3 
    lizard
    (Anolis carolinensis)
    Reptilia HELZ6
    helicase with zinc finger
    82(a)
    1 ↔ 1
    GL343250.1(420411-622104)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.99842 Xenopus laevis transcribed sequence with weak similarity more 75.27(n)    BJ625391.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL914540.12   -- 78.86(n)    AL914540.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG94253   -- 49(a)   70F6   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAM76
    ATP-dependent RNA helicase of the SFI superfamily ...
    16(a)
    1 → many
    XIII(426712-429627) YMR080C


    ENSEMBL Gene Tree for HELZ (if available)
    TreeFam Gene Tree for HELZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HELZ gene
    HELZ22  MOV10L12  MOV102  UPF12  ZGRF12  

    Find genes that share paralogs with HELZ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HELZ (see all 3072)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115415971,2
    C--60478961(+) TTGGT-/GAGA  
            
    GAGAG
    1 -- int11Minor allele frequency- GAGA:0.50CSA 2
    rs1821360791,2
    --65066058(+) CACAAC/TCAGCA 1 -- ds50010--------
    rs113795351,2
    C--65066063(+) CAGCA-/T/TTT 
            
    TTTTT
    2 -- ds5001 cds11CSA 2
    rs65044861,2
    C,F,H--65066096(+) TAATGC/TTTGGC 1 -- ds500127Minor allele frequency- T:0.27NA NS EA WA CSA 2488
    rs1417621921,2
    --65066103(+) TGGCAC/TGCATT 1 -- ds50010--------
    rs1867993111,2
    --65066139(+) CATAAC/TATATC 1 -- ds50010--------
    rs1916483781,2
    --65066323(+) TAACAC/TGTTTA 1 -- ds50010--------
    rs1504171151,2
    --65066384(+) ATGTCC/TGGAAA 1 -- ds50010--------
    rs1382270811,2
    --65066532(+) TTATAA/GTTCAC 1 -- ds50010--------
    rs1495970371,2
    --65066663(+) CAATGA/CGCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HELZ (65066554 - 65242105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HELZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2558362CNV Insertion19546169
    nsv469731CNV Loss16826518
    nsv908690CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606699    OMIM disorders: --

    1 disease for HELZ:    
    About MalaCards
    nonepidermolytic palmoplantar keratoderma

    1 disease from the University of Copenhagen DISEASES database for HELZ:
    Nonepidermolytic palmoplantar keratoderma

    Find genes that share disorders with HELZ           About GenesLikeMe

    Genetic Association Database (GAD): HELZ
    Human Genome Epidemiology (HuGE) Navigator: HELZ (1 document)

    Export disorders for HELZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HELZ gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with HELZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. (PubMed id 12691822)1, 2, 3 Nagai H.... Emi M. (Cancer Lett. 2003)
    2. Identification of a differentially expressed RNA helicase by gene trapping. (PubMed id 10471385)1, 2, 3 Wagner D.S.... Klein W.H. (Biochem. Biophys. Res. Commun. 1999)
    3. Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. (PubMed id 20378664)1, 4 Sombekke M.H....Uitdehaag B.M. (Mult. Scler. 2010)
    4. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. (PubMed id 15235609)1, 2 Hamamoto R.... Nakamura Y. (Nat. Cell Biol. 2004)
    5. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation. (PubMed id 21765940)1 Hasgall P.A....Camenisch G. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9931 HGNC: 16878 AceView: HELZ Ensembl:ENSG00000198265 euGenes: HUgn9931
    ECgene: HELZ H-InvDB: HELZ

    (According to HUGE)
    About This Section

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    HUGE: KIAA0054

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HELZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HELZ gene:
    Search GeneIP for patents involving HELZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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