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Aliases for HELZ Gene

Aliases for HELZ Gene

  • Helicase With Zinc Finger 2 3 5
  • Down-Regulated In Human Cancers Protein 3 4
  • DRHC 3 4
  • Probable Helicase With Zinc Finger Domain 3
  • Helicase With Zinc Finger Domain 3
  • Down-Regulated In Human Cancers 2
  • EC 3.6.4.- 4
  • KIAA0054 4
  • HUMORF5 3
  • DHRC 3

External Ids for HELZ Gene

Previous GeneCards Identifiers for HELZ Gene

  • GC17P063140
  • GC17P066240
  • GC17M065491
  • GC17M065624
  • GC17M062504
  • GC17M065066
  • GC17M060455

Summaries for HELZ Gene

Entrez Gene Summary for HELZ Gene

  • HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HELZ Gene

HELZ (Helicase With Zinc Finger) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and helicase activity. An important paralog of this gene is MOV10L1.

UniProtKB/Swiss-Prot for HELZ Gene

  • May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELZ Gene

Genomics for HELZ Gene

Regulatory Elements for HELZ Gene

Enhancers for HELZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F067430 1.3 FANTOM5 Ensembl ENCODE 71 -191.7 -191716 14.6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF207 FOS JUNB REST HELZ NOL11 MIR548AA2 MIR548D2 LOC100418928 PITPNC1 ENSG00000267731 SLC16A6 LRRC37A16P BPTF
GH17F066451 0.6 Ensembl ENCODE 58.1 +793.8 793789 1.6 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 SP5 JUNB HELZ AXIN2 PRKCA-AS1 GC17M066521
GH17F068019 0.8 Ensembl ENCODE 47.9 -774.2 -774194 2.0 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NOL11 HELZ LRRC37A16P SH3GL1P3 FBXO36P1 ENSG00000264421 RPL36AP48 TRR-CCG2-1 KPNA2
GH17F066506 1.2 Ensembl ENCODE 25.9 +737.3 737273 4.1 CREB3L1 DMAP1 FEZF1 YBX1 YY1 ZNF416 ZNF143 ZNF263 SP3 NFYC HELZ ENSG00000264421 RPL36AP48 ENSG00000270870 PRKCA-AS1 APOH PRKCA GC17M066521
GH17F067992 1.1 FANTOM5 ENCODE 25.1 -748.8 -748805 4.5 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 ZNF302 NOL11 LRRC37A16P HELZ C17orf58 ENSG00000265100 ENSG00000267731 WIPI1 LOC440461 AMZ2 BPTF
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HELZ on UCSC Golden Path with GeneCards custom track

Promoters for HELZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001351649 889 3401 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 FOS

Genomic Location for HELZ Gene

67,070,438 bp from pter
67,245,989 bp from pter
175,552 bases
Minus strand

Genomic View for HELZ Gene

Genes around HELZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HELZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HELZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELZ Gene

Proteins for HELZ Gene

  • Protein details for HELZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable helicase with zinc finger domain
    Protein Accession:
    Secondary Accessions:
    • I6L9H4

    Protein attributes for HELZ Gene

    1942 amino acids
    Molecular mass:
    218970 Da
    Quaternary structure:
    • Interacts with SMYD2 (By similarity). Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II.
    • Sequence=BAA06147.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HELZ Gene


neXtProt entry for HELZ Gene

Post-translational modifications for HELZ Gene

  • Ubiquitination at Lys 56
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HELZ Gene

Domains & Families for HELZ Gene

Suggested Antigen Peptide Sequences for HELZ Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DNA2/NAM7 helicase family.
  • Contains 1 C3H1-type zinc finger.
  • Belongs to the DNA2/NAM7 helicase family.
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with HELZ: view

Function for HELZ Gene

Molecular function for HELZ Gene

UniProtKB/Swiss-Prot Function:
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.

Enzyme Numbers (IUBMB) for HELZ Gene

Gene Ontology (GO) - Molecular Function for HELZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HELZ: view
genes like me logo Genes that share phenotypes with HELZ: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HELZ Gene

Localization for HELZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HELZ Gene

Subcellular locations from

Jensen Localization Image for HELZ Gene COMPARTMENTS Subcellular localization image for HELZ gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HELZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HELZ: view

Pathways & Interactions for HELZ Gene

SuperPathways for HELZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HELZ Gene


No data available for Pathways by source and SIGNOR curated interactions for HELZ Gene

Transcripts for HELZ Gene

Unigene Clusters for HELZ Gene

Helicase with zinc finger:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HELZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2: -
SP4: - -
SP5: -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1: -

Relevant External Links for HELZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HELZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HELZ Gene

Protein differential expression in normal tissues from HIPED for HELZ Gene

This gene is overexpressed in Breast (18.1), Testis (17.3), Peripheral blood mononuclear cells (11.8), and Plasma (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HELZ Gene

Protein tissue co-expression partners for HELZ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HELZ Gene:


SOURCE GeneReport for Unigene cluster for HELZ Gene:


mRNA Expression by UniProt/SwissProt for HELZ Gene:

Tissue specificity: Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested cancer cell lines.
genes like me logo Genes that share expression patterns with HELZ: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HELZ Gene

Orthologs for HELZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HELZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HELZ 34 35
  • 99.67 (n)
(Canis familiaris)
Mammalia HELZ 34 35
  • 94.22 (n)
(Bos Taurus)
Mammalia HELZ 34 35
  • 89.47 (n)
(Rattus norvegicus)
Mammalia Helz 34
  • 87.97 (n)
(Mus musculus)
Mammalia Helz 34 16 35
  • 87.83 (n)
(Monodelphis domestica)
Mammalia HELZ 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia HELZ 35
  • 85 (a)
(Gallus gallus)
Aves -- 35
  • 86 (a)
  • 82.91 (n)
-- 35
  • 82 (a)
(Anolis carolinensis)
Reptilia HELZ 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia helz 34
  • 71.86 (n)
Str.15539 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9984 34
(Danio rerio)
Actinopterygii helz 34 35
  • 66.84 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5746 34
fruit fly
(Drosophila melanogaster)
Insecta CG9425 36 35
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 35
  • 16 (a)
Species where no ortholog for HELZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HELZ Gene

Gene Tree for HELZ (if available)
Gene Tree for HELZ (if available)

Paralogs for HELZ Gene

Paralogs for HELZ Gene

genes like me logo Genes that share paralogs with HELZ: view

Variants for HELZ Gene

Sequence variations from dbSNP and Humsavar for HELZ Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1035176 -- 67,160,803(-) GTTTT(C/G)ATGCA intron-variant
rs10438780 -- 67,223,090(+) aaaat(A/C)caaaa intron-variant
rs10445332 -- 67,135,457(+) tctcc(C/T)tcact intron-variant
rs10491170 -- 67,085,903(-) ACTCT(A/G)AACTT intron-variant
rs10512514 -- 67,215,760(+) ATGTC(A/C)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HELZ Gene

Variant ID Type Subtype PubMed ID
dgv3276n100 CNV loss 25217958
esv2558362 CNV insertion 19546169
nsv1059962 CNV loss 25217958
nsv1067245 CNV loss 25217958
nsv1120054 OTHER inversion 24896259
nsv1125640 CNV tandem duplication 24896259
nsv469731 CNV loss 16826518
nsv960525 CNV duplication 23825009

Variation tolerance for HELZ Gene

Residual Variation Intolerance Score: 4.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.24; 90.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HELZ Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELZ Gene

Disorders for HELZ Gene

Relevant External Links for HELZ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HELZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HELZ Gene

Publications for HELZ Gene

  1. Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. (PMID: 12691822) Nagai H. … Emi M. (Cancer Lett. 2003) 2 3 4 64
  2. Identification of a differentially expressed RNA helicase by gene trapping. (PMID: 10471385) Wagner D.S. … Klein W.H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 64
  3. Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. (PMID: 20378664) Sombekke M.H. … Uitdehaag B.M. (Mult. Scler. 2010) 3 46 64
  4. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. (PMID: 15235609) Hamamoto R. … Nakamura Y. (Nat. Cell Biol. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4 64

Products for HELZ Gene

Sources for HELZ Gene

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