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Aliases for HELT Gene

Aliases for HELT Gene

  • Helt BHLH Transcription Factor 2 3
  • HES/HEY-Like Transcription Factor 2 3 4
  • Megane BHLH Factor 2 3
  • Hairy And Enhancer Of Split-Related Protein HELT 3
  • Hey-Like Transcription Factor (Zebrafish) 2
  • Hey-Like Transcriptional Repressor 3
  • Hey-Like Transcription Factor 3
  • HES-Like 2
  • HCM1228 3
  • Heslike 3
  • BHLHb44 3
  • HESL 3
  • Mgn 3

External Ids for HELT Gene

Previous GeneCards Identifiers for HELT Gene

  • GC04P186635
  • GC04P186315
  • GC04P186177
  • GC04P185940
  • GC04P181693

Summaries for HELT Gene

GeneCards Summary for HELT Gene

HELT (Helt BHLH Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein homodimerization activity. An important paralog of this gene is HEYL.

UniProtKB/Swiss-Prot for HELT Gene

  • Transcriptional repressor which binds preferentially to the canonical E box sequence 5-CACGCG-3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELT Gene

Genomics for HELT Gene

Regulatory Elements for HELT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HELT Gene

Start:
185,018,841 bp from pter
End:
185,020,804 bp from pter
Size:
1,964 bases
Orientation:
Plus strand

Genomic View for HELT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HELT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELT Gene

Proteins for HELT Gene

  • Protein details for HELT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFD8-HELT_HUMAN
    Recommended name:
    Hairy and enhancer of split-related protein HELT
    Protein Accession:
    A6NFD8
    Secondary Accessions:
    • B2RTS5
    • B7ZMI7
    • B7ZMI8

    Protein attributes for HELT Gene

    Size:
    242 amino acids
    Molecular mass:
    26913 Da
    Quaternary structure:
    • Self-associates. Interacts with HES5 and HEY2 (By similarity).

    Alternative splice isoforms for HELT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HELT Gene

Proteomics data for HELT Gene at MOPED

Post-translational modifications for HELT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HELT Gene

No data available for DME Specific Peptides for HELT Gene

Domains for HELT Gene

Gene Families for HELT Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for HELT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HELT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFD8

UniProtKB/Swiss-Prot:

HELT_HUMAN :
  • A6NFD8
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
Family:
  • Belongs to the HEY family.
genes like me logo Genes that share domains with HELT: view

Function for HELT Gene

Molecular function for HELT Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5-CACGCG-3.

Gene Ontology (GO) - Molecular Function for HELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0046983 protein dimerization activity --
genes like me logo Genes that share ontologies with HELT: view
genes like me logo Genes that share phenotypes with HELT: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HELT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HELT Gene

Localization for HELT Gene

Subcellular locations from UniProtKB/Swiss-Prot for HELT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HELT Gene COMPARTMENTS Subcellular localization image for HELT gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for HELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with HELT: view

Pathways for HELT Gene

SuperPathways for HELT Gene

No Data Available

Gene Ontology (GO) - Biological Process for HELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001967 suckling behavior IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007417 central nervous system development IEA --
genes like me logo Genes that share ontologies with HELT: view

No data available for Pathways by source for HELT Gene

Transcripts for HELT Gene

mRNA/cDNA for HELT Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HELT Gene

Helt bHLH transcription factor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HELT

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HELT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HELT Gene

No ASD Table

Relevant External Links for HELT Gene

GeneLoc Exon Structure for
HELT
ECgene alternative splicing isoforms for
HELT

Expression for HELT Gene

mRNA expression in normal human tissues for HELT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HELT Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (20.5), Skin - Not Sun Exposed (Suprapubic) (13.4), Kidney - Cortex (7.6), and Lung (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HELT Gene

SOURCE GeneReport for Unigene cluster for HELT Gene Hs.531242

genes like me logo Genes that share expressions with HELT: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HELT Gene

Orthologs for HELT Gene

This gene was present in the common ancestor of animals.

Orthologs for HELT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HELT 35
  • 99.69 (n)
  • 99.69 (a)
HELT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HELT 35
  • 89.45 (n)
  • 91.98 (a)
HELT 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HELT 35
  • 90.01 (n)
  • 92.41 (a)
HELT 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Helt 35
  • 85.96 (n)
  • 91.49 (a)
Helt 16
Helt 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HELT 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Helt 35
  • 86.52 (n)
  • 92.34 (a)
chicken
(Gallus gallus)
Aves HELT 35
  • 71.03 (n)
  • 64.83 (a)
lizard
(Anolis carolinensis)
Reptilia HELT 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia helt 35
  • 69.48 (n)
  • 72.89 (a)
zebrafish
(Danio rerio)
Actinopterygii helt 35
  • 71.59 (n)
  • 77.62 (a)
helt 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cwo 36
  • 9 (a)
OneToOne
Species with no ortholog for HELT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HELT Gene

ENSEMBL:
Gene Tree for HELT (if available)
TreeFam:
Gene Tree for HELT (if available)

Paralogs for HELT Gene

Paralogs for HELT Gene

Selected SIMAP similar genes for HELT Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HELT: view

Variants for HELT Gene

Sequence variations from dbSNP and Humsavar for HELT Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs901433 -- 185,020,161(-) TTCCC(A/G)TTTGA intron-variant
rs901434 -- 185,020,042(-) ACCAG(C/T)CTCCC intron-variant
rs1078461 - 185,019,798(+) AGTAC(C/G)TGAGA reference, missense
rs1486662 -- 185,017,980(-) AATGT(C/G)CATTG upstream-variant-2KB
rs1486665 -- 185,017,317(+) TTCAC(A/G)GGGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HELT Gene

Variant ID Type Subtype PubMed ID
nsv461859 CNV Loss 19166990
nsv822881 CNV Gain 20364138

Relevant External Links for HELT Gene

HapMap Linkage Disequilibrium report
HELT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELT Gene

Disorders for HELT Gene

Relevant External Links for HELT

Genetic Association Database (GAD)
HELT
genes like me logo Genes that share disorders with HELT: view

No data available for UniProtKB/Swiss-Prot for HELT Gene

Publications for HELT Gene

  1. Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system. (PMID: 14764602) Nakatani T. … Ono Y. (J. Biol. Chem. 2004) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. (PMID: 17611227) Nakatani T. … Ono Y. (Development 2007) 2 3
  5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PMID: 20508642) Krebs A.R. … Tora L. (EMBO Rep. 2010) 3

Products for HELT Gene

Sources for HELT Gene

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