Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HELT Gene

protein-coding GIFtS: 40
GCID: GC04P185940

helt bHLH transcription factor

(Previous names: Hey-like transcription factor (zebrafish), HES/HEY-like...)

Explore 6 diseases affiliated with
HELT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Helt BHLH Transcription Factor¹ ²		Hey-Like Transcription Factor (Zebrafish)¹
HES/HEY-Like Transcription Factor¹ ² ³		Heslike²
HCM1228¹ ²		Hairy And Enhancer Of Split-Related Protein HELT²
HESL¹ ²		Hey-Like Transcription Factor²
Mgn¹ ²		Hey-Like Transcriptional Repressor²
BHLHb44¹		Megane BHLH Factor²
MEGANE¹

External Ids:	HGNC: 33783¹	Entrez Gene: 391723²	Ensembl: ENSG00000187821⁷	UniProtKB: A6NFD8³

Export aliases for HELT gene to outside databases

Previous GC identifers: GC04P186635 GC04P186315 GC04P186177 GC04P181693

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HELT_HUMAN, A6NFD8

Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3' (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HELT gene promoter:
GATA-3 GATA-1 GATA-2 HEN1 Cart-1 SEF-1 (1) Chx10 En-1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HELT promoter sequence

Search SABiosciences Chromatin IP Primers for HELT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HELT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1

HELT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HELT gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P185940: view genomic region (about GC identifiers)

Start:	185,939,995 bp from pter	End:	185,941,958 bp from pter
Size:	1,964 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HELT_HUMAN, A6NFD8 (See protein sequence)

Recommended Name: Hairy and enhancer of split-related protein HELT

Size: 327 amino acids; 35816 Da

Subunit: Self-associates. Interacts with HES5 and HEY2 (By similarity)

Subcellular location: Nucleus (By similarity)

Secondary accessions: B2RTS5 B7ZMI8

Alternative splicing: 2 isoforms: A6NFD8-1 A6NFD8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HELT: NX_A6NFD8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A6NFD8

HELT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001025058.1

ENSEMBL proteins:

ENSP00000422140 ENSP00000426033 ENSP00000343464

Human Recombinant Protein Products for HELT:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: HELT OriGene Protein Over-expression Lysate: HELT OriGene Custom Protein Services for HELT
	GenScript Custom Purified and Recombinant Proteins Services for HELT
	Novus Biologicals HELT Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HELT

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005667	transcription factor complex	IEA	--

HELT for ontologies About GeneDecksing

HELT Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HELT
	GenScript Custom Superior Antibodies Services for HELT
	Novus Biologicals HELT Antibody
	Search for Antibodies for HELT at Abcam
	Uscn Antibodies for HELT
	Search ThermoFisher Antibodies for HELT

Assay Products for HELT:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HELT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HELT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HELT for domains About GeneDecksing

2 InterPro domains/families:

IPR003650 Orange

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry A6NFD8

ProtoNet protein and cluster: A6NFD8

UniProtKB/Swiss-Prot: HELT_HUMAN, A6NFD8

Similarity: Belongs to the HEY family

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 Orange domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HELT_HUMAN, A6NFD8

Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3' (By

similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0042803	protein homodimerization activity	IEA	--

HELT for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Helt):

behavior/neurological

growth/size

mortality/aging

nervous system

HELT for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HELT

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HELT
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HELT
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HELT (see all 4) OriGene shRNA RFP: HELT OriGene siRNA: HELT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HELT
		Sirion Biotech Custom design and validation of potent shRNA sequences against HELT

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HELT
			Sirion Biotech Customized adenovirus for overexpression of HELT Sirion Biotech Customized adenovirus for potent knockdown of HELT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HELT (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HELT OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HELT (NM_001029887)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HELT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HELT
		Search LifeMap BioReagents cell lines for HELT
		Sirion Biotech Customized stable knockdown cell line services for HELT Sirion Biotech Customized inducible knockdown cell line services for HELT Sirion Biotech Customized stable overexpressing cell line services for HELT Sirion Biotech Customized inducible overexpressing cell line services for HELT

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HELT

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HELT

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for HELT (A6NFD8³ ENSP00000343464⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TADA2A	O75478³, ENSP00000225396⁴	I2D: score=1 STRING: ENSP00000225396
HEY2	Q9UBP5³	I2D: score=1

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001967	suckling behavior	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007417	central nervous system development	IEA	--

HELT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HELT
Search CenterWatch for drugs/clinical trials and news about HELT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HELT gene:

NM_001029887.1

Unigene Cluster for HELT:

Helt bHLH transcription factor

Hs.531242 [show with all ESTs]

Unigene Representative Sequence: BC144568

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000505610(uc003ixa.3) ENST00000515777(uc011cko.2) ENST00000513599(uc011ckp.1)

ENST00000338875(uc011ckq.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HELT
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HELT
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HELT (see all 4) OriGene shRNA RFP: HELT OriGene siRNA: HELT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HELT
		Sirion Biotech Custom design and validation of potent shRNA sequences against HELT

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HELT (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HELT OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HELT (NM_001029887)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HELT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HELT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HELT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HELT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HELT

Additional cDNA sequence:

BC140795.1 BC144567.1 BC144568.1 BC144569.1

1 DOTS entry:

DT.91796163

2 AceView cDNA sequences:

BI763541 BI763994

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HELT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAACCTGG

About this image

HELT expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HELT Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.531242

SABiosciences Custom PCR Arrays for HELT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HELT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HELT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HELT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HELT

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HELT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HELT gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Helt^{1 , 5}	helt bHLH transcription factor^{1, 5}	85.96(n)¹ 91.49(a)¹		8 (26.32 cM)⁵ 234219¹ NM_173789.4¹ NP_776150.2¹ 46292050⁵
lizard (Anolis carolinensis)	Reptilia	HELT⁶	--	71(a)	1 ↔ 1	5(113066652-113072586)
zebrafish (Danio rerio)	Actinopterygii	helt¹	hey-like transcription factor	71.43(n) 77.62(a)		404275 NM_207065.2 NP_996948.1
fruit fly (Drosophila melanogaster)	Insecta	cwo⁶	clockwork orange	7(a)	1 ↔ 1	3R(6213985-6226477)

ENSEMBL Gene Tree for HELT (if available)
TreeFam Gene Tree for HELT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HELT gene

HEYL² HES4² HES6² HEY2² HES7² HES3² HEY1² HES5²

HES2² HES1²

1 SIMAP similar gene for HELT using alignment to 2 protein entries: HELT_HUMAN (see all proteins):

HEYL

HELT for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151273382^1,2		--	185938210(+)	`CAGAGC/TCCCCA`	1	--	us2k¹		0	--	--	--	--
rs1486665^1,2	C,F,A,H	--	185938471(+)	`TTCACG/AGGGCC`	1	--	us2k¹		23		MN EA NA NS WA CSA	1507
rs140339627^1,2		--	185938482(+)	`CTTTTC/GAGTGA`	1	--	us2k¹		0	--	--	--	--
rs150346023^1,2		--	185938558(+)	`AAGGGA/GGACAT`	1	--	us2k¹		0	--	--	--	--
rs182703337^1,2		--	185939124(+)	`TCATAC/GTTTTC`	1	--	us2k¹		0	--	--	--	--
rs1486662^1,2	C	--	185939134(-)	`AATGTC/GCATTG`	1	--	us2k¹		5		MN CSA WA NA EA	544
rs78649677^1,2		--	185939143(+)	`TTTTCG/TTATAG`	1	--	us2k¹		1		EA	120
rs187340700^1,2		--	185939238(+)	`AGGGAA/GTAGGG`	1	--	us2k¹		0	--	--	--	--
rs138102921^1,2		--	185939370(+)	`AAGGGC/GGGAGA`	1	--	us2k¹		0	--	--	--	--
rs192134623^1,2		--	185939456(+)	`AACCCA/GGCGGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HELT (185939995 - 185941958 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HELT: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HELT

DNA2.0 Custom Variant and Variant Library Synthesis for HELT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HELT for disorders About GeneDecksing

6 diseases for HELT: About MalaCards

membranous glomerulonephritis glomerulonephritis lupus erythematosus hepatitis b

hepatitis neuronitis

5 diseases from the University of Copenhagen DISEASES database for HELT:

Glomerulonephritis Nephrotic syndrome Proteinuria Lupus erythematosus

Kidney failure

Export disorders for HELT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HELT gene integrated from 9 sources:
(articles sorted by number of sources associating them with HELT)

Utopia: connect your pdf to the dynamic
world of online information

Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. (PubMed id 17611227)^{1, 3} Nakatani T....Ono Y. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system. (PubMed id 14764602)^{1, 3} Nakatani T....Ono Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)¹ Krebs A.R....Tora L. (2010)
Molecular characterization, structure and developmental expression of Megane bHLH factor. (PubMed id 16644143)¹ Guimera J....Wurst W. (2006)
Identification and characterization of human HESL, rat Hesl and rainbow trout hesl genes in silico. (PubMed id 15375612)¹ Katoh M. and Katoh M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 391723	HGNC: 33783	AceView: LOC285435	Ensembl:ENSG00000187821	euGenes: HUgn391723
ECgene: HELT	H-InvDB: HELT

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HELT	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HELT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HELT gene:
Search GeneIP for patents involving HELT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HELT
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HELT		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HELT
	OriGene Protein Over-expression Lysate for HELT		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HELT		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HELT		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HELT
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HELT		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HELT		OriGene Custom Protein Services for HELT
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HELT
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HELT
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HELT
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HELT
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HELT
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HELT

	GenScript Custom Purified and Recombinant Proteins Services for HELT		GenScript cDNA clones with any tag delivered in your preferred vector for HELT
	GenScript Custom Assay Services for HELT		GenScript Custom Superior Antibodies Services for HELT
	GenScript Custom overexpressing Cell Line Services for HELT		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HELT promoter
	Search Chromatin IP Primers for HELT
	RT² qPCR Primer Assay in human, mouse, rat HELT
	Search GNC Networks for HELT
	SABiosciences Custom PCR Arrays for HELT

Search Tocris compounds for HELT

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HELT antibodies
	HELT lysates

	Search for Antibodies for HELT at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HELT
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HELT Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HELT

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HELT

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HELT
	SwitchGear Promoter luciferase reporter plasmids for HELT

Search ThermoFisher Antibodies for HELT

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELT

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HELT

Sirion Biotech Customized:

	stable knockdown cell line services for HELT
	inducible knockdown cell line services for HELT
	design and validation of potent shRNA sequences against HELT
	adenovirus for potent knockdown of HELT
	adenovirus for overexpression of HELT
	stable overexpressing cell line services for HELT
	inducible overexpressing cell line services for HELT

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HELT gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

HELT Gene

helt bHLH transcription factor

Aliases
for HELT gene

Summaries
for HELT gene

Genomic Views
for HELT gene

Proteins
for HELT gene

Protein Domains /
Families
for HELT gene

Function
for HELT gene

Pathways & Interactions
for HELT gene

Drugs & Compounds
for HELT gene

Transcripts
for HELT gene

Expression
for HELT gene

Orthologs
for HELT gene

Paralogs
for HELT gene

Genomic Variants
for HELT gene

Disorders / Diseases
for HELT gene

Publications
for HELT gene

External Searches for HELT gene

Genome Databases showing HELT gene

Other Databases showing HELT gene

Specialized Databases showing HELT gene

Intellectual Property
for HELT gene

Products
for HELT gene

View Random Gene

Advanced Search

Export list of displayed genes

HELT Gene

helt bHLH transcription factor

Aliasesfor HELT gene

Summariesfor HELT gene

Genomic Viewsfor HELT gene

Proteinsfor HELT gene

Protein Domains /Familiesfor HELT gene

Functionfor HELT gene

Pathways & Interactionsfor HELT gene

Drugs & Compoundsfor HELT gene

Transcriptsfor HELT gene

Expression for HELT gene

Orthologsfor HELT gene

Paralogsfor HELT gene

Genomic Variantsfor HELT gene

Disorders / Diseasesfor HELT gene

Publicationsfor HELT gene

External Searches for HELT gene

Genome Databases showing HELT gene

Other Databases showing HELT gene

Specialized Databases showing HELT gene

Intellectual Propertyfor HELT gene

Productsfor HELT gene

View Random Gene

Aliases
for HELT gene

Summaries
for HELT gene

Genomic Views
for HELT gene

Proteins
for HELT gene

Protein Domains /
Families
for HELT gene

Function
for HELT gene

Pathways & Interactions
for HELT gene

Drugs & Compounds
for HELT gene

Transcripts
for HELT gene

Expression
for HELT gene

Orthologs
for HELT gene

Paralogs
for HELT gene

Genomic Variants
for HELT gene

Disorders / Diseases
for HELT gene

Publications
for HELT gene

Intellectual Property
for HELT gene

Products
for HELT gene