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HELT Gene

protein-coding   GIFtS: 40
GCID: GC04P185940

Helt BHLH Transcription Factor

(Previous names: Hey-like transcription factor (zebrafish), HES/HEY-like...)
  Search for HELT
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Helt BHLH Transcription Factor1 2     Heslike2
HES/HEY-Like Transcription Factor1 2 3     Mgn2
Megane BHLH Factor1 2     bHLHb442
HES-like1     Hairy And Enhancer Of Split-Related Protein HELT2
Hey-Like Transcription Factor (Zebrafish)1     Hey-Like Transcription Factor2
HCM12282     Hey-Like Transcriptional Repressor2
HESL2     

External Ids:    HGNC: 337831   Entrez Gene: 3917232   Ensembl: ENSG000001878217   UniProtKB: A6NFD83   

Export aliases for HELT gene to outside databases

Previous GC identifers: GC04P186635 GC04P186315 GC04P186177 GC04P181693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HELT Gene:
HELT (helt bHLH transcription factor) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HEYL.

UniProtKB/Swiss-Prot: HELT_HUMAN, A6NFD8
Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3' (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HELT gene promoter:
         GATA-3   GATA-1   GATA-2   HEN1   Cart-1   SEF-1 (1)   Chx10   En-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHELT promoter sequence
   Search Chromatin IP Primers for HELT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HELT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

HELT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HELT gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P185940:  view genomic region     (about GC identifiers)

Start:
185,939,995 bp from pter      End:
185,941,958 bp from pter
Size:
1,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HELT_HUMAN, A6NFD8 (See protein sequence)
Recommended Name: Hairy and enhancer of split-related protein HELT  
Size: 327 amino acids; 35816 Da
Subunit: Self-associates. Interacts with HES5 and HEY2 (By similarity)
Secondary accessions: B2RTS5 B7ZMI8
Alternative splicing: 2 isoforms:  A6NFD8-1   A6NFD8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HELT: NX_A6NFD8

Explore proteomics data for HELT at MOPED


See HELT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001025058.1  
ENSEMBL proteins: 
 ENSP00000426033   ENSP00000422140   ENSP00000343464  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
bHLH: Basic helix-loop-helix proteins

2 InterPro protein domains:
 IPR003650 Orange
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry A6NFD8

ProtoNet protein and cluster: A6NFD8

UniProtKB/Swiss-Prot: HELT_HUMAN, A6NFD8
Similarity: Belongs to the HEY family
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
Similarity: Contains 1 Orange domain


Find genes that share domains with HELT           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HELT_HUMAN, A6NFD8
Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3' (By
similarity)

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0042803protein homodimerization activity IEA--
GO:0046983protein dimerization activity ----
     
Find genes that share ontologies with HELT           About GenesLikeMe


Phenotypes:
     4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Helt):
 behavior/neurological  growth/size/body  mortality/aging  nervous system 

Find genes that share phenotypes with HELT           About GenesLikeMe

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HELT_HUMAN, A6NFD8: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005667transcription factor complex IEA--

Find genes that share ontologies with HELT           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HELT
Interactions:

    Search GeneGlobe Interaction Network for HELT

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for HELT (A6NFD83 ENSP000003434644) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
HEY2Q9UBP53I2D: score=1 
TCF12ENSP000003310574STRING: ENSP00000331057
TCF3ENSP000002629654STRING: ENSP00000262965
TCF4ENSP000003464404STRING: ENSP00000346440
About this table

Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0001967suckling behavior IEA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007417central nervous system development IEA--

Find genes that share ontologies with HELT           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HELT



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HELT gene: 
NM_001029887.1  

Unigene Cluster for HELT:

Helt bHLH transcription factor
Hs.531242  [show with all ESTs]
Unigene Representative Sequence: BC144568
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000515777(uc011cko.2) ENST00000513599(uc011ckp.1) ENST00000505610(uc003ixa.3)
ENST00000338875(uc011ckq.2)
miRNA
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GenScript: all cDNA clones in your preferred vector: HELT (NM_001029887)
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Additional mRNA sequence: 

BC140795.1 BC144567.1 BC144568.1 BC144569.1 

1 DOTS entry:

DT.91796163 

2 AceView cDNA sequences:

BI763541 BI763994 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HELT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAACCTGG
HELT Expression
About this image


HELT expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Mesencephalic Ventricular Zone
HELT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HELT Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.531242
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELT

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HELT gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Helt1 , 5 helt bHLH transcription factor1, 5 85.96(n)1
91.49(a)1
  8 (26.32 cM)5
2342191  NM_173789.41  NP_776150.21 
 462920505 
chicken
(Gallus gallus)
Aves HELT1 helt bHLH transcription factor 71.03(n)
64.83(a)
  101750337  XM_004941132.1  XP_004941189.1 
lizard
(Anolis carolinensis)
Reptilia HELT6
helt bHLH transcription factor
81(a)
1 ↔ 1
5(113066165-113072833)
tropical clawed frog
(Xenopus tropicalis)
Amphibia helt1 helt bHLH transcription factor 69.48(n)
72.89(a)
  100486939  XM_002934266.2  XP_002934312.2 
zebrafish
(Danio rerio)
Actinopterygii helt1 hey-like transcription factor 71.59(n)
77.62(a)
  404275  NM_207065.2  NP_996948.1 
fruit fly
(Drosophila melanogaster)
Insecta cwo6
clockwork orange
9(a)
1 ↔ 1
3R(6213985-6226477)


ENSEMBL Gene Tree for HELT (if available)
TreeFam Gene Tree for HELT (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HELT gene
HEYL2  HEY12  HEY22  
1 SIMAP similar gene for HELT using alignment to 2 protein entries:     HELT_HUMAN (see all proteins):
HEYL

Find genes that share paralogs with HELT           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HELT (see all 112)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1512733821,2
--185938210(+) CAGAGC/TCCCCA 1 -- us2k10--------
rs14866651,2
C,F,A,H--185938471(+) TTCACG/AGGGCC 1 -- us2k123Minor allele frequency- A:0.25MN EA NA NS WA CSA 1507
rs1403396271,2
--185938482(+) CTTTTC/GAGTGA 1 -- us2k10--------
rs1503460231,2
--185938558(+) AAGGGA/GGACAT 1 -- us2k10--------
rs1827033371,2
--185939124(+) TCATAC/GTTTTC 1 -- us2k10--------
rs14866621,2
C--185939134(-) AATGTC/GCATTG 1 -- us2k15Minor allele frequency- G:0.14MN CSA WA NA EA 544
rs786496771,2
F--185939143(+) TTTTCG/TTATAG 1 -- us2k11Minor allele frequency- T:0.01EA 120
rs1873407001,2
--185939238(+) AGGGAA/GTAGGG 1 -- us2k10--------
rs1381029211,2
--185939370(+) AAGGGC/GGGAGA 1 -- us2k10--------
rs1921346231,2
--185939456(+) AACCCA/GGCGGA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for HELT (185939995 - 185941958 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HELT:    About this table    
Variant IDTypeSubtypePubMed ID
nsv461859CNV Loss19166990
nsv822881CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HELT
DNA2.0 Custom Variant and Variant Library Synthesis for HELT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with HELT           About GenesLikeMe

Genetic Association Database (GAD): HELT

Export disorders for HELT gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HELT gene integrated from 10 sources:
(articles sorted by number of sources associating them with HELT)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. (PubMed id 17611227)1, 3 Nakatani T....Ono Y. (Development 2007)
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system. (PubMed id 14764602)1, 3 Nakatani T....Ono Y. (J. Biol. Chem. 2004)
  5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)1 Krebs A.R....Tora L. (EMBO Rep. 2010)
  6. Molecular characterization, structure and developmental expression of Megane bHLH factor. (PubMed id 16644143)1 Guimera J....Wurst W. (Gene 2006)
  7. Identification and characterization of human HESL, rat Hesl and rainbow trout hesl genes in silico. (PubMed id 15375612)1 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 391723 HGNC: 33783 AceView: LOC285435 Ensembl:ENSG00000187821 euGenes: HUgn391723
ECgene: HELT H-InvDB: HELT

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HELT Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HELT gene:
Search GeneIP for patents involving HELT

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HELT  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HELT  
 OriGene MassSpec something-or-other for HELT   OriGene clones in human, mouse for HELT  
 OriGene qSTAR qPCR primer pairs in human, mouse for HELT   OriGene Purified Protein for HELT  
 OriGene ORF clones in mouse, rat for HELT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for HELT   OriGene Custom Protein Services for HELT  

 
 
 Block miRNA regulation of human, mouse, rat HELT using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HELT
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HELT Predesigned siRNA for gene silencing in human, mouse, rat HELT
 QuantiFast Probe-based Assays in human, mouse, rat HELT QuantiTect SYBR Green Assays in human, mouse, rat HELT
 Custom PCR Arrays for HELT Search Chromatin IP Primers for HELT
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HELT  Search GeneGlobe Interaction Network for HELT
 Regulatory tfbs in HELT promoter
 GenScript Custom Purified and Recombinant Proteins Services for HELT GenScript cDNA clones with any tag delivered in your preferred vector for HELT
 GenScript Custom Assay Services for HELT GenScript Custom overexpressing Cell Line Services for HELT
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Search Tocris compounds for HELT
 Browse Sino Biological Proteins
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 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 Search for Antibodies for HELT at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for HELT
 Custom Antibody / Protein Production Service
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for HELT
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELT
 Browse SwitchGear 3'UTR luciferase reporter plasmids for HELT
 SwitchGear Promoter luciferase reporter plasmids for HELT
 Search ThermoFisher Antibodies for HELT
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELT
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HELT
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HELT
 LSBio Antibodies in human, mouse, rat for HELT
Customized transgenic rodents for:
 Humanization
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 Off-target effect monitoring
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 Tissue-specific gene expresssion
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 Browse compounds at ApexBio
 Search Addgene for plasmids for HELT
  Search eBioscience for proteins for HELT
  Search eBioscience for elisas for HELT
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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