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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HELQ Gene

protein-coding   GIFtS: 51
GCID: GC04M084328

Helicase, POLQ-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Helicase, POLQ-Like1 2     DNA Helicase HEL3082
HEL3082 3 5     Helicase POLQ-Like2
Mus308-Like Helicase2 3     EC 3.6.4.123
POLQ-Like Helicase2 3     EC 3.6.18

External Ids:    HGNC: 185361   Entrez Gene: 1135102   Ensembl: ENSG000001633127   OMIM: 6067695   UniProtKB: Q8TDG43   

Export aliases for HELQ gene to outside databases

Previous GC identifers: GC04M084548 GC04M080071


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HELQ Gene:
HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 (PubMed
11751861)).(supplied by OMIM, Mar 2008)

GeneCards Summary for HELQ Gene: 
HELQ (helicase, POLQ-like) is a protein-coding gene. Diseases associated with HELQ include mutagen sensitivity, and meningioma. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is SNRNP200.

UniProtKB/Swiss-Prot: HELQ_HUMAN, Q8TDG4
Function: DNA-dependent ATPase and 5' to 3' DNA helicase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HELQ gene promoter:
         AhR   AML1a   FOXF2   p53   Pax-6   NF-kappaB   GATA-1   Arnt   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHELQ promoter sequence
   Search SABiosciences Chromatin IP Primers for HELQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HELQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.23

HELQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HELQ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M084328:  view genomic region     (about GC identifiers)

Start:
84,328,496 bp from pter      End:
84,377,025 bp from pter
Size:
48,530 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HELQ_HUMAN, Q8TDG4 (See protein sequence)
Recommended Name: Helicase POLQ-like  
Size: 1101 amino acids; 124131 Da
Subunit: Hexamer
Miscellaneous: ATPase activity is strongly stimulated by single-stranded DNA. Presence of ATP and Mg cofactor are
required for helicase activity allowing to unwind duplex oligonucleotides up to 60-70-mer. This helicase activity
is stimulated by replication protein RPA that binds to unwound regions and inhibits re-annealing
Secondary accessions: Q05DF9 Q502W9 Q659B8 Q6ZQX4 Q6ZTS4 Q96EX7
Alternative splicing: 4 isoforms:  Q8TDG4-1   Q8TDG4-2   Q8TDG4-4   Q8TDG4-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HELQ: NX_Q8TDG4

Explore proteomics data for HELQ at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDG4

  • 2 DME Specific Peptides for HELQ (Q8TDG4)
     NLPARRV  QMIGRAGR 

    HELQ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HELQ Protein Expression
    REFSEQ proteins: NP_598375.2  
    ENSEMBL proteins: 
     ENSP00000424186   ENSP00000295488   ENSP00000424539  

    Human Recombinant Protein Products for HELQ: 
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    Novus Biologicals HELQ Proteins
    Novus Biologicals HELQ Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HELQ 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    HELQ for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for HELQ


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q8TDG4

    ProtoNet protein and cluster: Q8TDG4

    UniProtKB/Swiss-Prot: HELQ_HUMAN, Q8TDG4
    Similarity: Belongs to the helicase family. SKI2 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    HELQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HELQ_HUMAN, Q8TDG4
    Function: DNA-dependent ATPase and 5' to 3' DNA helicase
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003676nucleic acid binding IEA--
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    HELQ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HELQ:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HELQ 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HELQ

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HELQ (Q8TDG43 ENSP000002954884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLNQ7Z5Q53, ENSP000003723164I2D: score=1 STRING: ENSP00000372316
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HELQ

    Search CenterWatch for drugs/clinical trials and news about HELQ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HELQ gene: 
    NM_133636.2  

    Unigene Cluster for HELQ:

    Helicase, POLQ-like
    Hs.480101  [show with all ESTs]
    Unigene Representative Sequence: NM_133636
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508591 ENST00000295488(uc003hom.3 uc010ikb.3 uc003hol.4 uc010ikc.3 uc003hon.1 uc003hop.1 uc003hoq.1)
    ENST00000512539 ENST00000510985(uc003hoo.1) ENST00000515482 ENST00000440639

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HELQ
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of HELQ 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HELQ
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HELQ

    Additional mRNA sequence: 

    AF436845.1 AK126255.1 AK128665.1 AK308395.1 AK312725.1 AL512702.1 BC011863.2 BC015428.1 
    BC065814.1 BC095473.1 BC111502.1 

    8 DOTS entries:

    DT.97838163  DT.70104407  DT.211107  DT.40258640  DT.95123726  DT.121274532  DT.405745  DT.86850986 

    24/84 AceView cDNA sequences (see all 84):

    BU686678 AI201192 Z38586 AI276683 AL702311 AI564470 AL512702 AI025810 
    Z42372 AA971008 AI948732 BI771202 AA283800 AA769245 AI627810 BM972744 
    CK000270 AI240831 AW024327 AA625285 AW192200 H59461 CK002367 BM986846 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HELQ    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                          -                 -           -                       -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                            -           -     -                 -                                                                           
    SP4:                    -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HELQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HELQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTTATTA
    HELQ Expression
    About this image


    See HELQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HELQ

    SOURCE GeneReport for Unigene cluster: Hs.480101
        SABiosciences Custom PCR Arrays for HELQ
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HELQ gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Helq1 , 5 helicase, POLQ-like1, 5 79.23(n)1
    78.5(a)1
      5 (48.52 cM)5
    1915781  NM_001081107.11  NP_001074576.11 
     1007621455 
    chicken
    (Gallus gallus)
    Aves HELQ1 helicase, POLQ-like 69.69(n)
    68.73(a)
      422606  XM_420565.1  XP_420565.1 
    lizard
    (Anolis carolinensis)
    Reptilia HELQ6
    helicase, POLQ-like
    61(a)
    1 ↔ 1
    5(43338252-43357290)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.168902 Transcribed sequence with weak similarity to protein more 75.89(n)    BM005035.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mus3011 mutagen-sensitive 301 50.04(n)
    45.2(a)
      38905  NM_139921.3  NP_648178.1 
    worm
    (Caenorhabditis elegans)
    Secernentea helq-11 Protein HELQ-1 47.66(n)
    38.13(a)
      175210  NM_001027740.2  NP_001022911.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SLH16
    Putative RNA helicase related to Ski2p, involved i...
    7(a)
    1 → many
    VII(1031791-1037694)


    ENSEMBL Gene Tree for HELQ (if available)
    TreeFam Gene Tree for HELQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HELQ gene
    SNRNP2002  POLN2  ASCC32  POLQ2  

    HELQ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1092 SNPs in HELQ are shown (see all 1092)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0426434
    A breast cancer sample4--see VAR_0426432 D N mis40--------
    VAR_0612134
    ----see VAR_0612132 V E mis40--------
    rs1452092341,2
    --84142843(+) CACATA/GCAGGA 1 -- int10--------
    rs170067911,2
    C,F,H--84142850(+) AGGACG/TTGGAC 1 -- int117Minor allele frequency- N:0.00NA NS EA 2206
    rs571486121,2
    --84142925(+) TAGGAA/GGGAAA 1 -- int10--------
    rs1487218331,2
    --84142954(+) TAGGGA/GTGAGG 1 -- int10--------
    rs1861887991,2
    --84142963(+) GGATGA/CACCTG 1 -- int10--------
    rs1920472011,2
    --84143031(+) TAGTGC/TATTTT 1 -- int10--------
    rs170067921,2
    C,F,H--84143105(+) CTAAGA/GAAAAT 1 -- int115Minor allele frequency- G:0.23NA NS EA WA CSA 782
    rs1423185921,2
    --84143112(+) AAATTA/CTGGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for HELQ (84328496 - 84377025 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HELQ:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675432CNV Deletion23128226
    nsv509909CNV Loss20534489
    nsv829992CNV Loss17160897
    nsv829994CNV Loss17160897
    nsv879512CNV Gain21882294


    Human Gene Mutation Database (HGMD): HELQ
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HELQ
    DNA2.0 Custom Variant and Variant Library Synthesis for HELQ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606769    OMIM disorders: --

    3 diseases for HELQ:    About MalaCards
    mutagen sensitivity    meningioma    tuberculosis


    HELQ for disorders           About GeneDecksing

    Genetic Association Database (GAD): HELQ
    Human Genome Epidemiology (HuGE) Navigator: HELQ (0 documents)

    Export disorders for HELQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HELQ gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with HELQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308. (PubMed id 11751861)1, 2, 3 Marini F. and Wood R.D. (2002)
    2. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1, 4 Stolk L....Lunetta K.L. (2012)
    3. A genome-wide association study of upper aerodigestiv e tract cancers conducted within the INHANCE consortium. (PubMed id 21437268)1, 4 McKay J.D....Brennan P. (2011)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Human HEL308 localizes to damaged replication forks a nd unwinds lagging strand structures. (PubMed id 21398521)1 Tafel A.A....McHugh P.J. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
    8. DNA polymerase POLN participates in cross-link repair and homologous recombination. (PubMed id 19995904)1 Moldovan G.L....D'Andrea A.D. (2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Comprehensive analysis of DNA repair gene variants and risk of meningioma. (PubMed id 18270339)1 Bethke L....Houlston R. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113510 HGNC: 18536 AceView: HEL308 Ensembl:ENSG00000163312 euGenes: HUgn113510
    ECgene: HELQ H-InvDB: HELQ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HELQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HELQ gene:
    Search GeneIP for patents involving HELQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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