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Aliases for HELQ Gene

Aliases for HELQ Gene

  • Helicase, POLQ-Like 2 3
  • HEL308 3 4 6
  • Mus308-Like Helicase 3 4
  • POLQ-Like Helicase 3 4
  • DNA Helicase HEL308 3
  • Helicase POLQ-Like 3
  • EC 3.6.4.12 4
  • EC 3.6.1 63

External Ids for HELQ Gene

Previous GeneCards Identifiers for HELQ Gene

  • GC04M084548
  • GC04M084328
  • GC04M080071

Summaries for HELQ Gene

Entrez Gene Summary for HELQ Gene

  • HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HELQ Gene

HELQ (Helicase, POLQ-Like) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is SNRNP200.

UniProtKB/Swiss-Prot for HELQ Gene

  • DNA-dependent ATPase and 5 to 3 DNA helicase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HELQ Gene

Genomics for HELQ Gene

Regulatory Elements for HELQ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HELQ Gene

Start:
83,407,343 bp from pter
End:
83,455,948 bp from pter
Size:
48,606 bases
Orientation:
Minus strand

Genomic View for HELQ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HELQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HELQ Gene

Proteins for HELQ Gene

  • Protein details for HELQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDG4-HELQ_HUMAN
    Recommended name:
    Helicase POLQ-like
    Protein Accession:
    Q8TDG4
    Secondary Accessions:
    • Q05DF9
    • Q502W9
    • Q659B8
    • Q6ZQX4
    • Q6ZTS4
    • Q96EX7

    Protein attributes for HELQ Gene

    Size:
    1101 amino acids
    Molecular mass:
    124131 Da
    Quaternary structure:
    • Hexamer.
    Miscellaneous:
    • ATPase activity is strongly stimulated by single-stranded DNA. Presence of ATP and Mg cofactor are required for helicase activity allowing to unwind duplex oligonucleotides up to 60-70-mer. This helicase activity is stimulated by replication protein RPA that binds to unwound regions and inhibits re-annealing

    Alternative splice isoforms for HELQ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HELQ Gene

Proteomics data for HELQ Gene at MOPED

Selected DME Specific Peptides for HELQ Gene

Post-translational modifications for HELQ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HELQ Gene

Domains for HELQ Gene

Protein Domains for HELQ Gene

Suggested Antigen Peptide Sequences for HELQ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDG4

UniProtKB/Swiss-Prot:

HELQ_HUMAN :
  • Q8TDG4
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the helicase family. SKI2 subfamily.
genes like me logo Genes that share domains with HELQ: view

No data available for Gene Families for HELQ Gene

Function for HELQ Gene

Molecular function for HELQ Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: DNA-dependent ATPase and 5 to 3 DNA helicase.

Enzyme Numbers (IUBMB) for HELQ Gene

Gene Ontology (GO) - Molecular Function for HELQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003676 nucleic acid binding IEA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HELQ: view
genes like me logo Genes that share phenotypes with HELQ: view

Animal Model Products

CRISPR Products

miRNA for HELQ Gene

miRTarBase miRNAs that target HELQ

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HELQ Gene

Localization for HELQ Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HELQ Gene COMPARTMENTS Subcellular localization image for HELQ gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HELQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with HELQ: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HELQ Gene

Pathways for HELQ Gene

SuperPathways for HELQ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HELQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 19995904
genes like me logo Genes that share ontologies with HELQ: view

No data available for Pathways by source for HELQ Gene

Transcripts for HELQ Gene

Unigene Clusters for HELQ Gene

Helicase, POLQ-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HELQ

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HELQ

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HELQ Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - -
SP2:
SP3: - - - -
SP4: - -
SP5:

ExUns: 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for HELQ Gene

GeneLoc Exon Structure for
HELQ
ECgene alternative splicing isoforms for
HELQ

Expression for HELQ Gene

mRNA expression in normal human tissues for HELQ Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HELQ Gene

SOURCE GeneReport for Unigene cluster for HELQ Gene Hs.480101

genes like me logo Genes that share expressions with HELQ: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HELQ Gene

Orthologs for HELQ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HELQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HELQ 35
  • 99.36 (n)
  • 99.09 (a)
HELQ 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 72 (a)
ManyToMany
HELQ 35
  • 86.27 (n)
  • 83.69 (a)
dog
(Canis familiaris)
Mammalia HELQ 35
  • 88.44 (n)
  • 85.94 (a)
HELQ 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Helq 35
  • 79.29 (n)
  • 78.6 (a)
Helq 16
Helq 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HELQ 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HELQ 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Helq 35
  • 78.98 (n)
  • 79.11 (a)
chicken
(Gallus gallus)
Aves HELQ 35
  • 69.72 (n)
  • 68.82 (a)
HELQ 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HELQ 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia helq 35
  • 66.77 (n)
  • 66.04 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16890 35
helq 35
  • 61.62 (n)
  • 60.88 (a)
helq 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012297 35
  • 48.26 (n)
  • 44.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta mus301 35
  • 50.48 (n)
  • 45.82 (a)
mus301 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea helq-1 35
  • 49.91 (n)
  • 41.2 (a)
helq-1 36
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRR2 36
  • 9 (a)
OneToMany
Species with no ortholog for HELQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HELQ Gene

ENSEMBL:
Gene Tree for HELQ (if available)
TreeFam:
Gene Tree for HELQ (if available)

Paralogs for HELQ Gene

Paralogs for HELQ Gene

genes like me logo Genes that share paralogs with HELQ: view

Variants for HELQ Gene

Sequence variations from dbSNP and Humsavar for HELQ Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs950874 -- 83,435,925(-) TCTCT(C/G)ATTAA intron-variant
rs1060972 -- 83,427,297(-) TTTTT(C/T)TTTCA intron-variant
rs1494961 -- 83,453,327(+) CTCAA(C/T)TGTTT missense, reference, utr-variant-5-prime, nc-transcript-variant, upstream-variant-2KB
rs1494962 -- 83,415,130(-) CAACT(A/G)TGGTT intron-variant
rs1565908 -- 83,426,270(+) TAACA(C/T)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HELQ Gene

Variant ID Type Subtype PubMed ID
nsv829992 CNV Loss 17160897
nsv509909 CNV Loss 20534489
esv2675432 CNV Deletion 23128226
nsv829994 CNV Loss 17160897
nsv879512 CNV Gain 21882294

Relevant External Links for HELQ Gene

HapMap Linkage Disequilibrium report
HELQ
Human Gene Mutation Database (HGMD)
HELQ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HELQ Gene

Disorders for HELQ Gene

Relevant External Links for HELQ

Genetic Association Database (GAD)
HELQ
Human Genome Epidemiology (HuGE) Navigator
HELQ
genes like me logo Genes that share disorders with HELQ: view

No data available for UniProtKB/Swiss-Prot for HELQ Gene

Publications for HELQ Gene

  1. A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308. (PMID: 11751861) Marini F. … Wood R.D. (J. Biol. Chem. 2002) 2 3 4
  2. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (PMID: 21437268) McKay J.D. … Brennan P. (PLoS Genet. 2011) 3 48
  3. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 48
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. (PMID: 24005565) Takata K. … Wood R.D. (Nat Commun 2013) 3

Products for HELQ Gene

Sources for HELQ Gene

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