HELQ Gene
protein-coding GIFtS: 49
GCID: GC04M084328
|
|
helicase, POLQ-like
| |
Aliases for HELQ gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Helicase, POLQ-Like1 2 | | DNA Helicase HEL3082 | | HEL3082 3 5 | | Helicase POLQ-Like2 | | Mus308-Like Helicase2 3 | | EC 3.6.4.123 | | POLQ-Like Helicase2 3 | | EC 3.6.18 | | Hel3081 | | |
Export aliases for HELQ gene to outside databasesPrevious GC identifers: GC04M084548 GC04M080071 |
Summaries for HELQ gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for HELQ: HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 (PubMed 11751861)).(suppliedby OMIM, Mar 2008) UniProtKB/Swiss-Prot: HELQ_HUMAN, Q8TDG4Function: DNA-dependent ATPase and 5' to 3' DNA helicase
|
Genomic Views for HELQ gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HELQ gene promoter: AhR AML1a FOXF2 p53 Pax-6 NF-kappaB GATA-1 Arnt NF-kappaB2 NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for HELQ
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HELQ |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q21.23 Ensembl cytogenetic band: 4q21.23 HGNC cytogenetic band: 4q21.23HELQ Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M084328: view genomic region
(about GC identifiers)
Start:
|
84,328,496 bp from pter |
End:
|
84,377,025 bp from pter |
Size:
|
48,530 bases |
Orientation:
|
minus strand |
|
Proteins for HELQ gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: HELQ_HUMAN, Q8TDG4 (See
protein sequence)Recommended Name: Helicase POLQ-like Size: 1101 amino acids; 124131 Da
Subunit: Hexamer
Miscellaneous: ATPase activity is strongly stimulated by single-stranded DNA. Presence of ATP and Mg cofactor arerequired for helicase activity allowing to unwind duplex oligonucleotides up to 60-70-mer. This helicase activity isstimulated by replication protein RPA that binds to unwound regions and inhibits re-annealing
Secondary accessions: Q05DF9 Q502W9 Q659B8 Q6ZQX4 Q6ZTS4 Q96EX7Alternative splicing: 4 isoforms: Q8TDG4-1 Q8TDG4-2 Q8TDG4-4 Q8TDG4-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HELQ: NX_Q8TDG4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TDG4 2 DME Specific Peptides for HELQ (Q8TDG4)
HELQ Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_598375.2 ENSEMBL proteins: ENSP00000424186 ENSP00000295488 ENSP00000424539 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HELQ for ontologies About GeneDecksing
HELQ Antibody Products: Assay Products for HELQ: |
Protein
Domains / Families for HELQ gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HELQ for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TDG4ProtoNet protein and cluster: Q8TDG4 UniProtKB/Swiss-Prot: HELQ_HUMAN, Q8TDG4Similarity: Belongs to the helicase family. SKI2 subfamilySimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain |
Function for HELQ gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: HELQ_HUMAN, Q8TDG4Function: DNA-dependent ATPase and 5' to 3' DNA helicaseCatalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HELQ (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HELQ OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HELQ (NM_133636) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HELQ | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELQ  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELQ |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
HELQ for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HELQ:
|
Pathways & Interactions for HELQ gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HELQ
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for HELQ (Q8TDG43 ENSP000002954884) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for HELQ gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for HELQ Search CenterWatch for drugs/clinical trials and news about HELQ 
|
Transcripts for HELQ gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for HELQ gene: NM_133636.2 Unigene Cluster for HELQ: Helicase, POLQ-like Hs.480101 [show with all ESTs]Unigene Representative Sequence: NM_1336366 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000508591 ENST00000295488(uc003hom.3 uc010ikb.3 uc003hol.4 uc010ikc.3 uc003hon.1 uc003hop.1 uc003hoq.1) ENST00000512539 ENST00000510985(uc003hoo.1) ENST00000515482 ENST00000440639
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HELQ (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HELQ OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HELQ (NM_133636) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HELQ | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELQ  |
Additional cDNA sequence: AF436845.1 AK126255.1 AK128665.1 AK308395.1 AK312725.1 AL512702.1 BC011863.2 BC015428.1 BC065814.1 BC095473.1 BC111502.1 8 DOTS entries: DT.97838163 DT.70104407 DT.211107 DT.40258640 DT.95123726 DT.121274532 DT.405745 DT.86850986 24/84 AceView cDNA sequences (see all 84): AI025810 AI276683 Z38586 Z42372 AW024327 AW192200 AI627810 AA625285 H59461 BU686678 AI201192 AA971008 AI240831 BI771202 BM972744 AA283800 AL512702 AA769245 CK000270 AI564470 AL702311 AI948732 BU508994 BE868968 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for HELQ About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 18 | ^ | 19 | |
| SP1: | |   | |   | |
| SP2: | |   | |   | |
| SP3: | |   | |   | |
| SP4: | |   | |   | |
| SP5: | |   | |   |
ECgene alternative splicing isoforms for HELQ
|
Expression for HELQ gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HELQ expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGTGTTATTA
About this image See HELQ Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HELQ
SOURCE GeneReport for Unigene cluster: Hs.480101 SABiosciences Custom PCR Arrays for HELQ
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HELQ Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HELQ | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HELQ | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HELQ | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELQ |
Orthologs for HELQ gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HELQ gene from 6/26 species (see all 26) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
HELQ1 |
helicase, POLQ-like |
69.69(n) 68.73(a) |
  |
422606 XM_420565.1 XP_420565.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.168902 |
Transcribed sequence with weak similarity to protein more |
75.89(n) |
  |
BM005035.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
mus3011 |
mutagen-sensitive 301 |
50.04(n) 45.2(a) |
  |
38905 NM_139921.3 NP_648178.1 |
worm (Caenorhabditis elegans) |
Secernentea |
helq-11 |
Protein HELQ-1 |
47.66(n) 38.13(a) |
  |
175210 NM_001027740.2 NP_001022911.1 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
emb15076AT2G422706 |
U5 small nuclear ribonucleoprotein helicase |
6(a)6(a) |
possible orthologpossible ortholog |
1(7301748-7310250) 2(17604330-17611333) |
rice (Oryza sativa) |
Liliopsida |
---- |
U5 small nuclear ribonucleoprotein 200 kDa helicas...U5 small nuclear ribonucleoprotein 200 kDa helicas... |
6(a)6(a) |
possible orthologpossible ortholog |
2(410661-418523) 3(30515962-30523987) |
ENSEMBL Gene Tree for HELQ (if available) TreeFam Gene Tree for HELQ (if available)  |
Paralogs for HELQ gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for HELQ gene
- SNRNP2002 ASCC32 POLQ2
HELQ for paralogs About GeneDecksing
|
Genomic Variants for HELQ gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Human Gene Mutation Database (HGMD): HELQ
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HELQ |
|
Disorders
/ Diseases for HELQ gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HELQ for disorders About GeneDecksing
OMIM gene information: 606769
OMIM disorders: --
5 diseases for HELQ: About MalaCardsmutagen sensitivity meningioma tuberculosis malaria mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: HELQ (0 documents) Export disorders for HELQ gene to outside databases
|
Publications for HELQ gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HELQ gene, integrated from 9 sources (see all 22): (articles sorted by number of sources associating them with HELQ) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308. (PubMed id 11751861)1, 2, 3 Marini F. and Wood R.D. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1 Stolk L....Lunetta K.L. (2012)
- A genome-wide association study of upper aerodigestiv e tract cancers conducted within the INHANCE consortium. (PubMed id 21437268)1 McKay J.D....Brennan P. (2011)
- Human HEL308 localizes to damaged replication forks a nd unwinds lagging strand structures. (PubMed id 21398521)1 Tafel A.A....McHugh P.J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- DNA polymerase POLN participates in cross-link repair and homologous recombination. (PubMed id 19995904)1 Moldovan G.L....D'Andrea A.D. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Comprehensive analysis of DNA repair gene variants and risk of meningioma. (PubMed id 18270339)1 Bethke L....Houlston R. (2008)
|
External Searches for HELQ gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HELQ gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HELQ gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HELQ gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for HELQ | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HELQ gene: Search GeneIP for patents involving HELQ
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for HELQ gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | Search Tocris compounds for HELQ |
| |  |  |  |  | | | | |
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 | | HELQ Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HELQ |
|  |  |  | | | ThermoFisher Antibody for HELQ |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HELQ |
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